|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
13-246 |
5.01e-132 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 372.59 E-value: 5.01e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 13 DPKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAHLALAKLQ 92
Cdd:PRK00481 11 DKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLL--DAKPNAAHRALAELE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 93 DaLGDRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDWTGDVTPEDK-CHCCqfPAPLRPHVVWFGEMP-- 169
Cdd:PRK00481 89 K-LGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPPrCPKC--GGILRPDVVLFGEMLpe 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
6RXP_A 170 LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 246
Cdd:PRK00481 166 LAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVEELLA 242
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
16-241 |
3.06e-120 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 341.88 E-value: 3.06e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 16 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQAFYNARRRQLQQPeiQPNAAHLALAKLQDAL 95
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRA--QPNPAHLALAELERRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 96 GDrFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDW--TGDVTPEDKCHCCqfPAPLRPHVVWFGEM-PLGM 172
Cdd:cd01412 79 PN-VLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENneEIPEEELPRCPKC--GGLLRPGVVWFGESlPLAL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
6RXP_A 173 DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 241
Cdd:cd01412 156 LEAVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
17-242 |
4.55e-114 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 327.12 E-value: 4.55e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAHLALAKLQDAlG 96
Cdd:COG0846 16 RIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLR--DAEPNAAHRALAELEKA-G 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 97 DRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDWTG-----DVTPEDKCHCCQfpAPLRPHVVWFGEM--P 169
Cdd:COG0846 93 KLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDvledlEGELPPRCPKCG--GLLRPDVVWFGEMlpE 170
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
6RXP_A 170 LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 242
Cdd:COG0846 171 EALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
23-196 |
7.46e-81 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 240.62 E-value: 7.46e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 23 GAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQA---FYNARRRQLqQPEIQPNAAHLALAKLQDAlGDRF 99
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWDpepFYNIARELL-PGEAQPNPAHYFIAKLEDK-GKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 100 LLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDW---TGDVTPEDKCHCCQFPAPLRPHVVWFGEM-PLGMDEI 175
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGetlYERIRPEKVPHCPQCGGLLKPDIVFFGENlPDKFHRA 158
|
170 180
....*....|....*....|.
6RXP_A 176 YMALSMADIFIAIGTSGHVYP 196
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00481 |
PRK00481 |
NAD-dependent deacetylase; Provisional |
13-246 |
5.01e-132 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 234777 Cd Length: 242 Bit Score: 372.59 E-value: 5.01e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 13 DPKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAHLALAKLQ 92
Cdd:PRK00481 11 DKAKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLL--DAKPNAAHRALAELE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 93 DaLGDRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDWTGDVTPEDK-CHCCqfPAPLRPHVVWFGEMP-- 169
Cdd:PRK00481 89 K-LGKLVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPPrCPKC--GGILRPDVVLFGEMLpe 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
6RXP_A 170 LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 246
Cdd:PRK00481 166 LAIDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAREHGAKTVEINLEPTPLDSLFDLVIHGKAGEVVPELVEELLA 242
|
|
| SIRT5_Af1_CobB |
cd01412 |
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ... |
16-241 |
3.06e-120 |
|
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.
Pssm-ID: 238703 Cd Length: 224 Bit Score: 341.88 E-value: 3.06e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 16 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQAFYNARRRQLQQPeiQPNAAHLALAKLQDAL 95
Cdd:cd01412 1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRA--QPNPAHLALAELERRL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 96 GDrFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDW--TGDVTPEDKCHCCqfPAPLRPHVVWFGEM-PLGM 172
Cdd:cd01412 79 PN-VLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENneEIPEEELPRCPKC--GGLLRPGVVWFGESlPLAL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
6RXP_A 173 DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 241
Cdd:cd01412 156 LEAVEALAKADLFLVIGTSGVVYPAAGLPEEAKERGARVIEINPEPTPLSPIADFAFRGKAGEVLPALL 224
|
|
| PTZ00408 |
PTZ00408 |
NAD-dependent deacetylase; Provisional |
17-247 |
3.83e-116 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 240405 Cd Length: 242 Bit Score: 332.17 E-value: 3.83e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDAL- 95
Cdd:PTZ00408 6 CITILTGAGISAESGISTFRDGNGLWENHRVEDVATPDAFLRNPALVQRFYNERRRALLSSSVKPNKAHFALAKLEREYr 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 96 GDRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDWTGDVT-PEDKCHCCQFPAPLRPHVVWFGEMPLGMDE 174
Cdd:PTZ00408 86 GGKVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDWTEDVVhGSSRCKCCGCVGTLRPHIVWFGEMPLYMDE 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
6RXP_A 175 IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 247
Cdd:PTZ00408 166 IESVMSKTDLFVAVGTSGNVYPAAGFVGRAQFYGATTLELNLEEGTNYSQFDESIYGKASVIVPAWVDRVLKL 238
|
|
| SIR2 |
COG0846 |
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ... |
17-242 |
4.55e-114 |
|
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440607 Cd Length: 243 Bit Score: 327.12 E-value: 4.55e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAHLALAKLQDAlG 96
Cdd:COG0846 16 RIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLR--DAEPNAAHRALAELEKA-G 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 97 DRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDWTG-----DVTPEDKCHCCQfpAPLRPHVVWFGEM--P 169
Cdd:COG0846 93 KLVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGKRYDLEDvledlEGELPPRCPKCG--GLLRPDVVWFGEMlpE 170
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
6RXP_A 170 LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 242
Cdd:COG0846 171 EALERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAGAPLVEINPEPTPLDSLADLVIRGDAGEVLPALVE 243
|
|
| SIR2-fam |
cd01407 |
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ... |
17-232 |
2.35e-92 |
|
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.
Pssm-ID: 238698 Cd Length: 218 Bit Score: 270.98 E-value: 2.35e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDV-GTPEGFDRDPELVQAFYNARRRQLQqpeIQPNAAHLALAKLQDAl 95
Cdd:cd01407 2 RIVVLTGAGISTESGIPDFRSPGGLWARLDPEELaFSPEAFRRDPELFWGFYRERRYPLN---AQPNPAHRALAELERK- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 96 GDRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDWTGDVTPED-----KCHCCQfpAPLRPHVVWFGEM-P 169
Cdd:cd01407 78 GKLKRVITQNVDGLHQRAGSPKVIELHGSLFRVRCTKCGKEYPRDELQADIDreevpRCPKCG--GLLRPDVVFFGESlP 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
6RXP_A 170 LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGP 232
Cdd:cd01407 156 EELDEAAEALAKADLLLVIGTSLQVYPAAGLPLYAPERGAPVVIINLEPTPADRKADLVILGD 218
|
|
| SIR2 |
pfam02146 |
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ... |
23-196 |
7.46e-81 |
|
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i
Pssm-ID: 426621 Cd Length: 179 Bit Score: 240.62 E-value: 7.46e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 23 GAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQA---FYNARRRQLqQPEIQPNAAHLALAKLQDAlGDRF 99
Cdd:pfam02146 1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVWDpepFYNIARELL-PGEAQPNPAHYFIAKLEDK-GKLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 100 LLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDW---TGDVTPEDKCHCCQFPAPLRPHVVWFGEM-PLGMDEI 175
Cdd:pfam02146 79 RLITQNIDGLHERAGSKKVVELHGSFAKARCVSCHQKYTGetlYERIRPEKVPHCPQCGGLLKPDIVFFGENlPDKFHRA 158
|
170 180
....*....|....*....|.
6RXP_A 176 YMALSMADIFIAIGTSGHVYP 196
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
|
|
| SIR2 |
cd00296 |
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ... |
17-218 |
1.05e-77 |
|
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.
Pssm-ID: 238184 [Multi-domain] Cd Length: 222 Bit Score: 234.16 E-value: 1.05e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVG-TPEGFDRDPELVQAFYNARRRQLqqPEIQPNAAHLALAKLQDA 94
Cdd:cd00296 2 RVVVFTGAGISTESGIPDFRgLGTGLWTRLDPEELAfSPEAFRRDPELFWLFYKERRYTP--LDAKPNPAHRALAELERK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 95 lGDRFLLVTQNCDNLHERAGN--TNVIHMHGELLKVRCSQSGQALDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL-- 170
Cdd:cd00296 80 -GKLKRIITQNVDGLHERAGSrrNRVIELHGSLDRVRCTSCGKEYPRDEVLEREKPPRCPKCGGLLRPDVVDFGEALPke 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
6RXP_A 171 GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 218
Cdd:cd00296 159 WFDRALEALLEADLVLVIGTSLTVYPAARLLLRAPERGAPVVIINREP 206
|
|
| SIR2_Af2 |
cd01413 |
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ... |
17-220 |
8.98e-52 |
|
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.
Pssm-ID: 238704 Cd Length: 222 Bit Score: 167.93 E-value: 8.98e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQAFYNARRRQLQqpEIQPNAAHLALAKLQdALG 96
Cdd:cd01413 6 KTVVLTGAGISTESGIPDFRSPDGLWKKYDPEEVASIDYFYRNPEEFWRFYKEIILGLL--EAQPNKAHYFLAELE-KQG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 97 DRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDW--TGDVTPEDKCHCCQFPAPLRPHVVWFGEM-PLG-M 172
Cdd:cd01413 83 IIKAIITQNIDGLHQRAGSKNVIELHGTLQTAYCVNCGSKYDLeeVKYAKKHEVPRCPKCGGIIRPDVVLFGEPlPQAlL 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
6RXP_A 173 DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 220
Cdd:cd01413 163 REAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENGAKLVIVNADETP 210
|
|
| SIR2H |
cd01411 |
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ... |
17-241 |
8.08e-40 |
|
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238702 Cd Length: 225 Bit Score: 137.50 E-value: 8.08e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEdvgTPEG------FDRDPElvqAFYNARRRQLQQPEIQPNAAHLALAK 90
Cdd:cd01411 10 RIVFFTGAGVSTASGIPDYRSKNGLYNEIYKY---SPEYllshdfLEREPE---KFYQFVKENLYFPDAKPNIIHQKMAE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 91 LQDAlgDRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQALDWTGDVTPE--DKCHccqfpAPLRPHVVWFGEM 168
Cdd:cd01411 84 LEKM--GLKAVITQNIDGLHQKAGSKNVVEFHGSLYRIYCTVCGKTVDWEEYLKSPyhAKCG-----GVIRPDIVLYEEM 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
6RXP_A 169 PLGM--DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKlHGAHTVELNLEPSQvgnefaekYYGPASQVVPEFV 241
Cdd:cd01411 157 LNESviEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQ-AGANLIAINKEPTQ--------LDSPATLVIKDAV 222
|
|
| PTZ00409 |
PTZ00409 |
Sir2 (Silent Information Regulator) protein; Provisional |
18-247 |
6.39e-37 |
|
Sir2 (Silent Information Regulator) protein; Provisional
Pssm-ID: 173599 [Multi-domain] Cd Length: 271 Bit Score: 131.20 E-value: 6.39e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 18 VLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVGTPEGFDRDPELVqafYNARRRQLQQPEIQPNAAHLALAKLQdALG 96
Cdd:PTZ00409 31 VVALTGSGTSAESNIPSFRgPSSSIWSKYDPKIYGTIWGFWKYPEKI---WEVIRDISSDYEIELNPGHVALSTLE-SLG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 97 DRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQAL-----------DWTGDVTPEdkCHCCQFpapLRPHVVWF 165
Cdd:PTZ00409 107 YLKFVVTQNVDGLHEESGNTKVIPLHGSVFEARCCTCRKTIqlnkimlqktsHFMHQLPPE--CPCGGI---FKPNVILF 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 166 GE-MPLG-MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQVVPefVE 242
Cdd:PTZ00409 182 GEvIPKSlLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRAHRKKKKIVEVNISKTYITNRISDYHVrAKFSELAQ--IS 259
|
....*
6RXP_A 243 KLLKG 247
Cdd:PTZ00409 260 DILKG 264
|
|
| SIRT7 |
cd01410 |
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ... |
16-220 |
2.28e-35 |
|
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238701 Cd Length: 206 Bit Score: 125.11 E-value: 2.28e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 16 PRVLVLTGAGISAESGIRTFRAADGLWEEHRvEDVGTPEgfdrdpelvqafYNARRRqlqqpEIQPNAAHLALAKLQDAl 95
Cdd:cd01410 1 KHLVVFTGAGISTSAGIPDFRGPNGVWTLLP-EDKGRRR------------FSWRFR-----RAEPTLTHMALVELERA- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 96 GDRFLLVTQNCDNLHERAGN--TNVIHMHGELLKVRCSQSGQ------ALDWTGDVTPEDKCHCCQfpAPLRPHVVWFGE 167
Cdd:cd01410 62 GLLKFVISQNVDGLHLRSGLprEKLSELHGNMFIEVCKSCGPeyvrddVVETRGDKETGRRCHACG--GILKDTIVDFGE 139
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
6RXP_A 168 -MPLG-MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 220
Cdd:cd01410 140 rLPPEnWMGAAAAACRADLFLCLGTSLQVTPAANLPLKAARAGGRLVIVNLQPTP 194
|
|
| SIRT4 |
cd01409 |
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ... |
15-218 |
2.42e-30 |
|
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.
Pssm-ID: 238700 Cd Length: 260 Bit Score: 113.55 E-value: 2.42e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 15 KPRVLVLTGAGISAESGIRTFRAADGLWeeHRVEDVGTPEGFDRDPelvqafyNARRR-----QLQQPEI---QPNAAHL 86
Cdd:cd01409 8 SRRLLVLTGAGISTESGIPDYRSEGGLY--SRTFRPMTHQEFMRSP-------AARQRywarsFVGWPRFsaaQPNAAHR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 87 ALAKLQDAlGDRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQ-------------------------SGQALDwtG 141
Cdd:cd01409 79 ALAALEAA-GRLHGLITQNVDGLHTKAGSRNVVELHGSLHRVVCLScgfrtpraelqdrlealnpgfaeqaAGQAPD--G 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 142 DVTPEDK---------CHCCQfpAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAH 210
Cdd:cd01409 156 DVDLEDEqvagfrvpeCERCG--GVLKPDVVFFGENvpRDRVVTAAARLAEADALLVLGSSLMVYSGYRFVLAAAEAGLP 233
|
....*...
6RXP_A 211 TVELNLEP 218
Cdd:cd01409 234 IAIVNIGP 241
|
|
| PRK05333 |
PRK05333 |
NAD-dependent protein deacetylase; |
16-216 |
1.93e-27 |
|
NAD-dependent protein deacetylase;
Pssm-ID: 235415 Cd Length: 285 Bit Score: 106.68 E-value: 1.93e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 16 PRVLVLTGAGISAESGIRTFRAADGLWEEhrvedvgTPegfdrdPELVQAFYN---ARRRQLQQPEI--------QPNAA 84
Cdd:PRK05333 20 PRLFVLTGAGISTDSGIPDYRDRNGQWKR-------SP------PITYQAFMGsdaARRRYWARSMVgwpvfgraQPNAA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 85 HLALAKLQDAlGDRFLLVTQNCDNLHERAGNTNVIHMHGELLKVRC-------------------------SQSGQALDw 139
Cdd:PRK05333 87 HHALARLGAA-GRIERLVTQNVDGLHQRAGSRDVIELHGRLDGVRCmgcgarhpraeiqhvleaanpewlaLEAAPAPD- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 140 tGDVTPED---------KCHCCQfpAPLRPHVVWFGE-MPLG-MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHG 208
Cdd:PRK05333 165 -GDADLEWaafdhfrvpACPACG--GILKPDVVFFGEnVPRErVAAARAALDAADAVLVVGSSLMVYSGYRFCVWAAQQG 241
|
....*...
6RXP_A 209 AHTVELNL 216
Cdd:PRK05333 242 KPIAALNL 249
|
|
| PRK14138 |
PRK14138 |
NAD-dependent deacetylase; Provisional |
20-216 |
1.13e-26 |
|
NAD-dependent deacetylase; Provisional
Pssm-ID: 172627 [Multi-domain] Cd Length: 244 Bit Score: 103.75 E-value: 1.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 20 VLTGAGISAESGIRTFRAADGLWEEHRvEDVGTPEGFDRDPElvqAFYN-ARRRQLQQPEIQPNAAHLALAKLQDAlGDR 98
Cdd:PRK14138 16 TLTGAGISTPSGIPDFRGPQGIYKKYP-QNVFDIDFFYSHPE---EFYRfAKEGIFPMLEAKPNLAHVLLAKLEEK-GLI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 99 FLLVTQNCDNLHERAGNTNVIHMHGELLKVRCSQSGQalDWTGD-------VTPEDKCHCCQfpAPLRPHVVWFGE-MPL 170
Cdd:PRK14138 91 EAVITQNIDRLHQKAGSKKVIELHGNVEEYYCVRCGK--RYTVEdviekleKSDVPRCDDCS--GLIRPNIVFFGEaLPQ 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
6RXP_A 171 -GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL 216
Cdd:PRK14138 167 dALREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVIVNL 213
|
|
| SIRT1 |
cd01408 |
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ... |
17-218 |
3.26e-16 |
|
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.
Pssm-ID: 238699 Cd Length: 235 Bit Score: 75.36 E-value: 3.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVGTPEG------FDRDPElvqAFYNArRRQLQQPEIQPNAAHLALA 89
Cdd:cd01408 2 KIVVLVGAGISTSAGIPDFRSPGtGLYANLARYNLPYPEAmfdisyFRKNPR---PFYAL-AKELYPGQFKPSVAHYFIK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 90 KLQDAlGDRFLLVTQNCDNLHERAG--NTNVIHMHGELLKVRCSQSGQALDwtGDVTPED-------KCHCCQfpAPLRP 160
Cdd:cd01408 78 LLEDK-GLLLRNYTQNIDTLERVAGvpDDRIIEAHGSFATAHCIKCKHKYP--GDWMREDifnqevpKCPRCG--GLVKP 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 161 HVVWFGE-MPLGMDEIYMALSM-ADIFIAIGTSGHVYPAAGFVHEAKLHgAHTVELNLEP 218
Cdd:cd01408 153 DIVFFGEsLPSRFFSHMEEDKEeADLLIVIGTSLKVAPFASLPSRVPSE-VPRVLINREP 211
|
|
| PTZ00410 |
PTZ00410 |
NAD-dependent SIR2; Provisional |
17-198 |
1.00e-09 |
|
NAD-dependent SIR2; Provisional
Pssm-ID: 185600 Cd Length: 349 Bit Score: 57.96 E-value: 1.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVGTPEGFDRDPELVQ---AFYN-ARRRQLQQPEIQPNAAHLALAKL 91
Cdd:PTZ00410 31 KILVMVGAGISVAAGIPDFRSPHtGIYAKLGKYNLNSPTDAFSLTLLREkpeVFYSiAREMDLWPGHFQPTAVHHFIRLL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 92 QDAlGDRFLLVTQNCDNLHERAG--NTNVIHMHGELLKVRCSQSGQALD--------WTGDVTpedkcHCCQFPAPLRPH 161
Cdd:PTZ00410 111 ADE-GRLLRCCTQNIDGLERAAGvpPSLLVEAHGSFSAASCIECHTPYDieqayleaRSGKVP-----HCSTCGGIVKPD 184
|
170 180 190
....*....|....*....|....*....|....*...
6RXP_A 162 VVWFGE-MPLGMDEIYMALSMADIFIAIGTSGHVYPAA 198
Cdd:PTZ00410 185 VVFFGEnLPDAFFNVHHDIPEAELLLIIGTSLQVHPFA 222
|
|
| SIR2-like |
cd01406 |
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key ... |
17-123 |
1.54e-05 |
|
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.
Pssm-ID: 238697 [Multi-domain] Cd Length: 242 Bit Score: 45.08 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RXP_A 17 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVG---TPEGFDRDPELVQAFY----------NARRRQLQQPEIQPN 82
Cdd:cd01406 2 RVVIFVGAGVSVSSGLPDWKTlLDEIASELGLEIDGysvEAKDENDYLELAELLEkefgtigikiNAVLEEKTRPDFEPS 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
6RXP_A 83 AAHLALAKLQDALGDRFLLVTQNCDNLHERA----------------------GNTNVIHMHG 123
Cdd:cd01406 82 PLHELLLRLFINNEGDVIIITTNYDRLLETAlkeinkvvkvivsvqlalsasaRFNGVYKIHG 144
|
|
| |
