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Conserved domains on  [gi|1866605467|pdb|6RZK|A]
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Chain A, Galectin-3

Protein Classification

galectin family protein( domain architecture ID 10049222)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 5-132 7.13e-51

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 157.80  E-value: 7.13e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RZK_A        5 PYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESG 83
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSsDIALHFNPRFDEN---VIVRNSFLNGNWGPEERSGGFPFQPG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
6RZK_A       84 KPFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 132
Cdd:cd00070  78 QPFELTILVEEDKFQIFVNGQHFFSFPHRL-PLESIDYLSINGDVSLTS 125
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 5-132 7.13e-51

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 157.80  E-value: 7.13e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RZK_A        5 PYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESG 83
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSsDIALHFNPRFDEN---VIVRNSFLNGNWGPEERSGGFPFQPG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
6RZK_A       84 KPFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 132
Cdd:cd00070  78 QPFELTILVEEDKFQIFVNGQHFFSFPHRL-PLESIDYLSINGDVSLTS 125
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 11-132 1.34e-50

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 156.98  E-value: 1.34e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RZK_A          11 PGGVVPRMLITILGTVKPNANRIALDFQRG--NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPFKI 88
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEG---TIVRNSKQNGKWGKEERSGGFPFQPGQPFEL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
6RZK_A          89 QVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 132
Cdd:smart00908  78 EILVEEDEFKVAVNGQHFLEFPHRL-PLESIDTLEISGDVQLTS 120
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 11-132 1.94e-46

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 146.63  E-value: 1.94e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RZK_A         11 PGGVVPRMLITILGTVKPNANRIALDFQRG----NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPF 86
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgpsDDIALHFNPRFDEN---VIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
6RZK_A         87 KIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 132
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRL-PPEDIDALQVRGDVKLTS 122
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
 5-132 7.13e-51

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 157.80  E-value: 7.13e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RZK_A        5 PYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESG 83
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGSsDIALHFNPRFDEN---VIVRNSFLNGNWGPEERSGGFPFQPG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
6RZK_A       84 KPFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 132
Cdd:cd00070  78 QPFELTILVEEDKFQIFVNGQHFFSFPHRL-PLESIDYLSINGDVSLTS 125
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
 11-132 1.34e-50

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 156.98  E-value: 1.34e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RZK_A          11 PGGVVPRMLITILGTVKPNANRIALDFQRG--NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPFKI 88
Cdd:smart00908   1 PGGLSPGSSITIRGIVLPDAKRFSINLQCGpnADIALHFNPRFDEG---TIVRNSKQNGKWGKEERSGGFPFQPGQPFEL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
6RZK_A          89 QVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 132
Cdd:smart00908  78 EILVEEDEFKVAVNGQHFLEFPHRL-PLESIDTLEISGDVQLTS 120
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
 6-136 5.13e-50

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 155.85  E-value: 5.13e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RZK_A           6 YNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGN-DVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGK 84
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTGGdDIALHFNPRFNEN---KIVCNSKLNGSWGSEEREGGFPFQPGQ 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
6RZK_A          85 PFKIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTSASYT 136
Cdd:smart00276  78 PFDLTIIVQPDHFQIFVNGVHITTFPHRL-PLESIDYLSINGDVQLTSVSFE 128
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
 11-132 1.94e-46

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 146.63  E-value: 1.94e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
6RZK_A         11 PGGVVPRMLITILGTVKPNANRIALDFQRG----NDVAFHFNPRFNENnrrVIVCNTKLDNNWGREERQSVFPFESGKPF 86
Cdd:pfam00337   1 PGGLQPGSSLTIKGIVLPDAQRFSINLQTGvgpsDDIALHFNPRFDEN---VIVRNSRQNGQWGQEEREGGFPFQPGQPF 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
6RZK_A         87 KIQVLVEPDHFKVAVNDAHLLQYNHRVkKLNEISKLGISGDIDLTS 132
Cdd:pfam00337  78 ELTILVGDDHFKIYVNGQHFTTFKHRL-PPEDIDALQVRGDVKLTS 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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