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Conserved domains on  [gi|2491196971|pdb|7UG8|B]
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Chain B, Ketoacid-binding protein

Protein Classification

TRAP transporter substrate-binding protein( domain architecture ID 10008687)

TRAP transporter substrate-binding protein functions as the receptor subunit of a Tripartite ATP-independent Periplasmic (TRAP) transporter complex

CATH:  3.40.190.170|3.40.190.10
Gene Ontology:  GO:0022857|GO:0008643|GO:0031317|GO:0005886
PubMed:  10627041|11524131|20584082|9287004
TCDB:  2.A.56

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FcbT1 COG4663
TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary ...
 5-334 0e+00

TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 443700 [Multi-domain]  Cd Length: 356  Bit Score: 533.93  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B        5 ASGLPQVRWRMATSWPISLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKN 84
Cdd:COG4663  27 AQAQPTIRWRMVTSWPKSLPGLGGAAERFAKRVEEMSGGRLKIKVFAAGELVPAFEVFDAVSNGTVEMGHTASYYWKGKD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       85 PAFAFGTAVPFGLSAQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGLGGKV 164
Cdd:COG4663 107 PAFAFFTAVPFGMNAREMNAWLYYGGGLELWRELYAKFNVVPFPAGNTGAQMGGWFRKEINSLDDLKGLKMRIPGLGGEV 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      165 MAKLGVNVQVLPGGEIYLALERGTIDAAEFTGPYDDEKLGLAKAAKHYYYPGWWEPGPTLMALVNRKAWSDLPKEYQAMF 244
Cdd:COG4663 187 LAKLGAVPQQLPGGEIYPALERGTIDAAEWVGPYDDEKLGFHKVAKYYYYPGWHEPGTQLELLVNKKAWDALPKDLQAIV 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      245 RTACYEANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADADAGFKALLERWRLFRRDTRRWN 324
Cdd:COG4663 267 EAAAAAANADMLAEYDARNPAALKRLVAEGVKLRRFPDEVLDALRKAADEVLAELAAKDPLFKKVYDSQKAFRKDVRLWF 346

                       330
                ....*....|
7UG8_B      325 NINELPLAEF 334
Cdd:COG4663 347 RVAELAYLNF 356
 
Name Accession Description Interval E-value
FcbT1 COG4663
TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary ...
 5-334 0e+00

TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443700 [Multi-domain]  Cd Length: 356  Bit Score: 533.93  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B        5 ASGLPQVRWRMATSWPISLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKN 84
Cdd:COG4663  27 AQAQPTIRWRMVTSWPKSLPGLGGAAERFAKRVEEMSGGRLKIKVFAAGELVPAFEVFDAVSNGTVEMGHTASYYWKGKD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       85 PAFAFGTAVPFGLSAQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGLGGKV 164
Cdd:COG4663 107 PAFAFFTAVPFGMNAREMNAWLYYGGGLELWRELYAKFNVVPFPAGNTGAQMGGWFRKEINSLDDLKGLKMRIPGLGGEV 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      165 MAKLGVNVQVLPGGEIYLALERGTIDAAEFTGPYDDEKLGLAKAAKHYYYPGWWEPGPTLMALVNRKAWSDLPKEYQAMF 244
Cdd:COG4663 187 LAKLGAVPQQLPGGEIYPALERGTIDAAEWVGPYDDEKLGFHKVAKYYYYPGWHEPGTQLELLVNKKAWDALPKDLQAIV 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      245 RTACYEANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADADAGFKALLERWRLFRRDTRRWN 324
Cdd:COG4663 267 EAAAAAANADMLAEYDARNPAALKRLVAEGVKLRRFPDEVLDALRKAADEVLAELAAKDPLFKKVYDSQKAFRKDVRLWF 346

                       330
                ....*....|
7UG8_B      325 NINELPLAEF 334
Cdd:COG4663 347 RVAELAYLNF 356
PBP2_TRAP_alpha-ketoacid cd13682
Substrate-binding component of an alpha-keto acid binding Tripartite ATP-independent ...
 12-334 0e+00

Substrate-binding component of an alpha-keto acid binding Tripartite ATP-independent Periplasmic transporter and related proteins; contains the type 2 periplasmic-binding protein fold; This subgroup includes TRAP transporters that bind to ketoacids such as pyruvate and alpha-ketobutyrate, xylulose, and other unknown ligands. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270400 [Multi-domain]  Cd Length: 323  Bit Score: 516.13  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       12 RWRMATSWPISLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFGT 91
Cdd:cd13682   1 RWRMASSFPKSLDTIYGGAEVLAKRVAEMTGGRFEIRVFPAGELVPALQVLDAVQNGTVECGHTASYYYIGKDPALAFDT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       92 AVPFGLSAQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGLGGKVMAKLGVN 171
Cdd:cd13682  81 AVPFGLTARQQNAWLYHGGGLELLRELYAQFNIINFPGGNTGVQMGGWFRKEIKTVADLKGLKMRIPGFGGEVMSRLGVV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      172 VQVLPGGEIYLALERGTIDAAEFTGPYDDEKLGLAKAAKHYYYPGWWEPGPTLMALVNRKAWSDLPKEYQAMFRTACYEA 251
Cdd:cd13682 161 VQNLPGGEIYPALERGAIDAAEWVGPYDDEKLGFNKVAPYYYYPGWWEPGPELTFYVNKDAWNALPPEYQAILEAAAAEA 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      252 NLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADADAGFKALLERWRLFRRDTRRWNNINELPL 331
Cdd:cd13682 241 NLDMLARYDALNPPALQRLLAEGTQLRPFPDEIMDAAYKAADELYAENSAKNPAFKKIYESWKAFREDIREWFRTAELAY 320


                ...
7UG8_B      332 AEF 334
Cdd:cd13682 321 DNF 323
DctP pfam03480
Bacterial extracellular solute-binding protein, family 7; This family of proteins is involved ...
 15-303 1.03e-67

Bacterial extracellular solute-binding protein, family 7; This family of proteins is involved in binding extracellular solutes for transport across the bacterial cytoplasmic membrane. This family includes Swiss:P37735, a C4-dicarboxylate-binding protein and the sialic acid-binding protein SiaP. The structure of the SiaP receptor has revealed an overall topology similar to ATP binding cassette ESR (extracytoplasmic solute receptors) proteins. Upon binding of sialic acid, SiaP undergoes domain closure about a hinge region and kinking of an alpha-helix hinge component.


Pssm-ID: 427325 [Multi-domain]  Cd Length: 286  Bit Score: 214.42  E-value: 1.03e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B         15 MATSWPiSLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFgTAVP 94
Cdd:pfam03480   1 FGHVAS-PGSPKHKAAEKFAKLVEEKTNGKIKIEVYPNSQLGGDREVIEALKLGTVDIGAPSSAYFGGLVPEIGV-FDLP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B         95 FGLSAQQQNTWLYYGGGNEDMNALFADFG--AVSFpAGNTGGQLGGwFKKPIQNLASLQGLKMRIP--GLGGKVMAKLGV 170
Cdd:pfam03480  79 FLFQDEEHLKKVLDGEVGEKLLKSLEKKGlkGLAF-WENGFRQFTN-NKKPINSPEDLKGLKLRVPpsPVLGEVFKALGA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B        171 NVQVLPGGEIYLALERGTIDAAEFTGPYdDEKLGLAKAAKHYYYPGwwEPGPTLMALVNRKAWSDLPKEYQAMFRTACYE 250
Cdd:pfam03480 157 NPTPMPFGEVYTALQTGVVDGQENPWSN-IYSQKFYEVQKYLTLTN--HGYLPYLVVVNKKTWDSLPEDYQAILEEAAKE 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
7UG8_B        251 ANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADAD 303
Cdd:pfam03480 234 ATEYQRKLAEELNEEALQKLKEAGVEIIELTPEDLAAFREAMKPVYKEIFAKD 286
TRAP_S1 NF037995
TRAP transporter substrate-binding protein DctP; Proteins of this family are members of the ...
 141-279 1.59e-12

TRAP transporter substrate-binding protein DctP; Proteins of this family are members of the superfamily of Tripartite ATP-independent Periplasmic Transporter (TRAP-T). They transport hydrophobic substrates, usually lipoprotein.


Pssm-ID: 468304 [Multi-domain]  Cd Length: 271  Bit Score: 66.85  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       141 KKPIQNLASLQGLKMRIPG---LGGKVMAKLGVNVQVLPGGEIYLALERGTIDAAEFTgPYDDEKLGLAKAAKHYYYPGW 217
Cdd:NF037995 124 KKPIRSPADLKGIKIWRTMgdpIHIAAFKALGANPVPLPIGEVLTALQTGVVDGAENP-PLGAVALQWYEVAKYMTDLPH 202

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
7UG8_B       218 -WEPGPTLMALvnrKAWSDLPKEYQAMFRTACYEANLGMLSNYEWRNSEALQRITRQGIKLER 279
Cdd:NF037995 203 aPVPGGLVISK---KAWNKLPPEYQAILRKAAAEAGEELRALVREDNAEALAKMKKAGVTVIE 262
dctP TIGR00787
tripartite ATP-independent periplasmic transporter solute receptor, DctP family; TRAP-T ...
 36-274 7.01e-12

tripartite ATP-independent periplasmic transporter solute receptor, DctP family; TRAP-T (Tripartite ATP-independent Periplasmic Transporter) family proteins generally consist of three components, and these systems have so far been found in Gram-negative bacteria, Gram-postive bacteria and archaea. The best characterized example is the DctPQM system of Rhodobacter capsulatus, a C4 dicarboxylate (malate, fumarate, succinate) transporter. This model represents the DctP family, one of at least three major families of extracytoplasmic solute receptor for TRAP family transporters. Other are the SnoM family (see pfam03480) and TAXI (TRAP-associated extracytoplasmic immunogenic) family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129869 [Multi-domain]  Cd Length: 257  Bit Score: 64.70  E-value: 7.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B         36 RVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFgTAVPFGLSAQQQNTWLYYGGGNEDM 115
Cdd:TIGR00787  21 LVNEKTNGEIKISVFPSSQLGSDRAMLEALQGGALDMTAPSSSKFGPLVPELAV-FDLPFLFRDYNHVHKVLDGEVGKAL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B        116 NALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGlgGKVMAK----LGVNVQVLPGGEIYLALERGTIDA 191
Cdd:TIGR00787 100 KKSLEKKGLKGLAYWDNGFRQFTSSKKPITKPEDLKGLKIRIPN--SPMNEAqfkaLGANPEPMAFSEVYTALQTGVVDG 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B        192 AEFTgpyddekLGLAKAAKHYYYPGW-------WEPGPTLMalvNRKAWSDLPKEYQAMFRTACYEANLGMLSNYEWRNS 264
Cdd:TIGR00787 178 QENP-------LSNVYSSKFYEVQKYlsmtnhgYLGYLVVV---NKAFWKSLPPDLQAVVKEAAKEAGEYQRKLSAEDEQ 247

                         250
                  ....*....|
7UG8_B        265 EALQRITRQG 274
Cdd:TIGR00787 248 KLIEKFKKQG 257
 
Name Accession Description Interval E-value
FcbT1 COG4663
TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary ...
 5-334 0e+00

TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443700 [Multi-domain]  Cd Length: 356  Bit Score: 533.93  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B        5 ASGLPQVRWRMATSWPISLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKN 84
Cdd:COG4663  27 AQAQPTIRWRMVTSWPKSLPGLGGAAERFAKRVEEMSGGRLKIKVFAAGELVPAFEVFDAVSNGTVEMGHTASYYWKGKD 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       85 PAFAFGTAVPFGLSAQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGLGGKV 164
Cdd:COG4663 107 PAFAFFTAVPFGMNAREMNAWLYYGGGLELWRELYAKFNVVPFPAGNTGAQMGGWFRKEINSLDDLKGLKMRIPGLGGEV 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      165 MAKLGVNVQVLPGGEIYLALERGTIDAAEFTGPYDDEKLGLAKAAKHYYYPGWWEPGPTLMALVNRKAWSDLPKEYQAMF 244
Cdd:COG4663 187 LAKLGAVPQQLPGGEIYPALERGTIDAAEWVGPYDDEKLGFHKVAKYYYYPGWHEPGTQLELLVNKKAWDALPKDLQAIV 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      245 RTACYEANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADADAGFKALLERWRLFRRDTRRWN 324
Cdd:COG4663 267 EAAAAAANADMLAEYDARNPAALKRLVAEGVKLRRFPDEVLDALRKAADEVLAELAAKDPLFKKVYDSQKAFRKDVRLWF 346

                       330
                ....*....|
7UG8_B      325 NINELPLAEF 334
Cdd:COG4663 347 RVAELAYLNF 356
PBP2_TRAP_alpha-ketoacid cd13682
Substrate-binding component of an alpha-keto acid binding Tripartite ATP-independent ...
 12-334 0e+00

Substrate-binding component of an alpha-keto acid binding Tripartite ATP-independent Periplasmic transporter and related proteins; contains the type 2 periplasmic-binding protein fold; This subgroup includes TRAP transporters that bind to ketoacids such as pyruvate and alpha-ketobutyrate, xylulose, and other unknown ligands. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270400 [Multi-domain]  Cd Length: 323  Bit Score: 516.13  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       12 RWRMATSWPISLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFGT 91
Cdd:cd13682   1 RWRMASSFPKSLDTIYGGAEVLAKRVAEMTGGRFEIRVFPAGELVPALQVLDAVQNGTVECGHTASYYYIGKDPALAFDT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       92 AVPFGLSAQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGLGGKVMAKLGVN 171
Cdd:cd13682  81 AVPFGLTARQQNAWLYHGGGLELLRELYAQFNIINFPGGNTGVQMGGWFRKEIKTVADLKGLKMRIPGFGGEVMSRLGVV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      172 VQVLPGGEIYLALERGTIDAAEFTGPYDDEKLGLAKAAKHYYYPGWWEPGPTLMALVNRKAWSDLPKEYQAMFRTACYEA 251
Cdd:cd13682 161 VQNLPGGEIYPALERGAIDAAEWVGPYDDEKLGFNKVAPYYYYPGWWEPGPELTFYVNKDAWNALPPEYQAILEAAAAEA 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      252 NLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADADAGFKALLERWRLFRRDTRRWNNINELPL 331
Cdd:cd13682 241 NLDMLARYDALNPPALQRLLAEGTQLRPFPDEIMDAAYKAADELYAENSAKNPAFKKIYESWKAFREDIREWFRTAELAY 320


                ...
7UG8_B      332 AEF 334
Cdd:cd13682 321 DNF 323
PBP2_TRAP_ketoacid_lactate_like cd13604
Substrate-binding domain of an alpha-keto acid binding Tripartite ATP-independent Periplasmic ...
 12-317 3.90e-130

Substrate-binding domain of an alpha-keto acid binding Tripartite ATP-independent Periplasmic transporter and related proteins; the type 2 periplasmic-binding protein fold; This family constitutes TRAP transporters that bind to ketoacids such as pyruvate and alpha-ketobutyrate, xylulose, and other unknown ligands. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270322 [Multi-domain]  Cd Length: 306  Bit Score: 374.22  E-value: 3.90e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       12 RWRMATSWPiSLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFGT 91
Cdd:cd13604   1 TLRMQTSWP-ALPGLGTGAEELAKRVEEMSGGRIKIEVFPAGSLVPAFETFDAVSNGTLDGGHTWPAYWSGKDPAFALFG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       92 AVPFGLSAQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGLGGKVMAKLGVN 171
Cdd:cd13604  80 AVPFGMDPLEYLAWLYYGGGKELLDELYAPFNVKPFPCGNTGPEAGGWFKKEIKSVEDLKGLKIRAPGLGGEVLARLGAS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      172 VQVLPGGEIYLALERGTIDAAEFTGPYDDEKLGLAKAAKHYYYPGWWEPGPTLMALVNRKAWSDLPKEYQAMFRTACYEA 251
Cdd:cd13604 160 PVNLPGGEIYTALERGAIDAAEFSGPANDLALGFHKVAKYYYYPGWHQPAPVLELIINKDVWEALPPDLQAIIEAACQAA 239

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
7UG8_B      252 NLGMLSNYEWRNSEALQRITRQ-GIKLERYGDDILKAARSASAEIFQELADADAGFKALLERWRLFR 317
Cdd:cd13604 240 NLDMLAEAEAQNAKALKELRAKgGVEVIRFPDEVLEAFRAAAQEVWEEEAAKDPLFKKVYDSQRAFR 306
PBP2_TRAP_Dctp5_like cd13684
Substrate-binding component of Tripartite ATP-independent Periplasmic transporter DctP5 and ...
 12-326 1.74e-89

Substrate-binding component of Tripartite ATP-independent Periplasmic transporter DctP5 and related proteins; the type 2 periplasmic-binding protein fold; This subgroup includes TRAP transporter DctP5 and its similar proteins. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270402 [Multi-domain]  Cd Length: 314  Bit Score: 271.12  E-value: 1.74e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       12 RWRMATSWPISLDTIYGgAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFGT 91
Cdd:cd13684   1 KWKMATSWPGGPFLQEF-AERFAERVKQLTNGRLVIQVFPAGVLVPALEVFDAVKNGVAEAGHSWPGYWVGKDPAFALFA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       92 AVPFGLSAQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGLGGKVMAKLGVN 171
Cdd:cd13684  80 SFPGGMNPEDYLLWLYEGGGKELYQELYGKFGLVYLPCGIGPTEIFAHSNKPIKTLEDLKGLKLRTSGAWAEILRKLGAS 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      172 VQVLPGGEIYLALERGTIDAAEFTGPYDDEKLGLAKAAKHYYYPGWWEPGPTLMALVNRKAWSDLPKEYQAMFRTACYEA 251
Cdd:cd13684 160 VVVLPGGEIYPALQRGVIDAAEFSTPSADYPLGFHEVAKYIMVPGVHQPASVFEVVINKKAWDALPPDLKALVEAAAKLT 239

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
7UG8_B      252 NLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADADAGFKALLERWRLFRRDTRRWNNI 326
Cdd:cd13684 240 TLESLARFEYQDIEAMEFFKKGGVEIVRLDPETLKELREIGNKWLDELAAEDPFFAKVLESQIAFRERWKNWKDY 314
DctP pfam03480
Bacterial extracellular solute-binding protein, family 7; This family of proteins is involved ...
 15-303 1.03e-67

Bacterial extracellular solute-binding protein, family 7; This family of proteins is involved in binding extracellular solutes for transport across the bacterial cytoplasmic membrane. This family includes Swiss:P37735, a C4-dicarboxylate-binding protein and the sialic acid-binding protein SiaP. The structure of the SiaP receptor has revealed an overall topology similar to ATP binding cassette ESR (extracytoplasmic solute receptors) proteins. Upon binding of sialic acid, SiaP undergoes domain closure about a hinge region and kinking of an alpha-helix hinge component.


Pssm-ID: 427325 [Multi-domain]  Cd Length: 286  Bit Score: 214.42  E-value: 1.03e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B         15 MATSWPiSLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFgTAVP 94
Cdd:pfam03480   1 FGHVAS-PGSPKHKAAEKFAKLVEEKTNGKIKIEVYPNSQLGGDREVIEALKLGTVDIGAPSSAYFGGLVPEIGV-FDLP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B         95 FGLSAQQQNTWLYYGGGNEDMNALFADFG--AVSFpAGNTGGQLGGwFKKPIQNLASLQGLKMRIP--GLGGKVMAKLGV 170
Cdd:pfam03480  79 FLFQDEEHLKKVLDGEVGEKLLKSLEKKGlkGLAF-WENGFRQFTN-NKKPINSPEDLKGLKLRVPpsPVLGEVFKALGA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B        171 NVQVLPGGEIYLALERGTIDAAEFTGPYdDEKLGLAKAAKHYYYPGwwEPGPTLMALVNRKAWSDLPKEYQAMFRTACYE 250
Cdd:pfam03480 157 NPTPMPFGEVYTALQTGVVDGQENPWSN-IYSQKFYEVQKYLTLTN--HGYLPYLVVVNKKTWDSLPEDYQAILEEAAKE 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
7UG8_B        251 ANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADAD 303
Cdd:pfam03480 234 ATEYQRKLAEELNEEALQKLKEAGVEIIELTPEDLAAFREAMKPVYKEIFAKD 286
PBP2_TRAP_DctP6_7 cd13683
Substrate-binding domain of Tripartite ATP-independent Periplasmic transporter DctP6 and DctP7; ...
 12-314 1.22e-64

Substrate-binding domain of Tripartite ATP-independent Periplasmic transporter DctP6 and DctP7; type 2 periplasmic-binding protein fold; This subgroup includes TRAP-type mannitol/chloroaromatic compound transport system (Dctp6) and similar proteins. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the PBP2 superfamily. The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270401 [Multi-domain]  Cd Length: 304  Bit Score: 206.77  E-value: 1.22e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       12 RWRMATSWPISLdtiYGGAVT--ICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAF 89
Cdd:cd13683   1 KWRFQTHLPKGT---SEEDVIkeFADRVNEMSNGRLVIEVFHAGELVPTPEVLRAVQRGVVDMALIYGGYWAGQAPVAAL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       90 GTAVPFG-LSAQQQNTWLYYGGGNEDMNALFADFGaVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGLGGKVMAKL 168
Cdd:cd13683  78 EGGLPGAtRSAAEVNALFYEPGLADILREAYAEQG-VHYLGPAPVDPLYLVSKKPINSLDDLKGLKIRASGTAAKFLQKL 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      169 GVNVQVLPGGEIYLALERGTIDAAEFTGPYDDEKLGLAKAAKHYYYPGWWePGPTLMALVNRKAWSDLPKEYQAMFRTAC 248
Cdd:cd13683 157 GASPVSLPASELYTALQTGVIDGAIWGSWAENYLMGLHEVTKYFLYLHIL-GAQTGELIVNMKAWESLPDDLKAIVETAL 235

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      249 ----YEANLGMLSNYEWRNSEALqritRQGIKLERYGDDILKAARSASAEIFQELADADAGFKALLERWR 314
Cdd:cd13683 236 deasYDRAAHAVDWEWEAEAKME----AKGIELIQLPEEDVAILAEAASKVWDEYAEKSPRAAKYVEILR 301
PBP2_TRAP cd13527
Substrate-binding component of Tripartite ATP-independent Periplasmic transporters and ...
 13-314 6.22e-58

Substrate-binding component of Tripartite ATP-independent Periplasmic transporters and related proteins; contains the type 2 periplasmic-binding protein fold; This family represents the TRAP Transporters that are specific to various ligands, including sialic acid (N-acetyl neuraminic acid), glutamate, ectoine, xylulose, C4-dicarboxylates such as succinate, malate and fumarate, and keto acids such as pyruvate and alpha-ketobutyrate. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. This family also includes some eukaryotic homologs that have not been functionally characterized. TRAP transporters are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270245 [Multi-domain]  Cd Length: 301  Bit Score: 189.55  E-value: 6.22e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       13 WRMATSWPiSLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFgTA 92
Cdd:cd13527   2 LRLAMNAP-PSSYEYKAAEMFAKEVKEKSQGKLEIKVFSSSQLGDGRNMLKALKQGSVDIGFVLSAYFSGFDPEFAL-FA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       93 VPFGLS-AQQQNTWLYYGGGNEDMNALFAD-FGAVSFPAGNTGGQLGGWFKkPIQNLASLQGLKMRIPG-LGGKVMAKLG 169
Cdd:cd13527  80 LPFVISsYNVIEKAWKAGETGDELNQELDKkLGIVLLSGAPNGPQQITSNR-AINSLADMKGLKLRVPGaANSRYAKLLG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      170 VNVQVLPGGEIYLALERGTIDAAEFTGPYDDEKLgLAKAAKHYYYPgwWEPGPTLMALVNRKAWSDLPKEYQAMFRTACY 249
Cdd:cd13527 159 ASPTSIPFSEVYLALQTGVVDGTENPLATVQSQK-LWEVVKYYYDA--NHFIPTSLYLVNKRAYDSLPPEIQKLVRDAAE 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
7UG8_B      250 EANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQE-LADADAGFKALLERWR 314
Cdd:cd13527 236 NADAEHTQLAVAKEKDLVTFFEKNGVEITPPDPELLQAMRAALKPYYAEwVKQAGQKGEDALKAIR 301
PBP2_TRAP_lactate cd13681
Substrate-binding component of a lactate binding Tripartite ATP-independent Periplasmic ...
 12-311 6.02e-56

Substrate-binding component of a lactate binding Tripartite ATP-independent Periplasmic transporter and related proteins; the type 2 periplasmic-binding protein fold; This subgroup includes a lactate binding TRAP transporter and its similar proteins. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270399 [Multi-domain]  Cd Length: 311  Bit Score: 184.69  E-value: 6.02e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       12 RWRMATSWPISlDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFGT 91
Cdd:cd13681   1 RWRMQTAWDGG-TVGYKTFERFCKRVKELTDGELEIEPFPAGAVVGTFEMFDAVRGGVLDGMNTFTLYWAGKMPATAFLS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       92 AVPFGLS-AQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQLGGwFKKPIQNLASLQGLKMRIP-GLGGKVMAKLG 169
Cdd:cd13681  80 SYPMGLPePDQWEAWFYSLGGLQIAREAYAPQGLYYIGPVQHGPNIIH-SKVPLRSIEDFKGKKLRFPgGMIAEVFAALG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      170 VNVQVLPGGEIYLALERGTIDAAEFTGPYDDEKLGLAKAAKHYYYPGWWEPGP----TLMAL-VNRKAWSDLPKEYQAMF 244
Cdd:cd13681 159 VATTLLPGGEVYSALEKGVIDAADFVGPAVNYDLGFHQVAKYIIMGPPGTPGIhqpvDLMDFvVNRNAWESLPAPYKAAL 238

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
7UG8_B      245 RTACYEANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELA--DADAG--FKALLE 311
Cdd:cd13681 239 AAAVREYSAAHRAAIQKADGEAWPKYKAAGVEVIRLSPEDLAKFRAQAIPIWFKWAnkDKDAArlFKSQLE 309
DctP COG1638
TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and ...
 10-314 3.01e-40

TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism];


Pssm-ID: 441245 [Multi-domain]  Cd Length: 329  Bit Score: 144.21  E-value: 3.01e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       10 QVRWRMATSWPISlDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAF 89
Cdd:COG1638  25 AVTLKLAHVLPPG-HPWGKAAEKFAEEVEERTGGRIKVEVFPGGQLGKEPEVLEAVRDGAVDMAAVSPGYLSGFVPEFGV 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       90 gTAVPFGLSAQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQlgGWF--KKPIQNLASLQGLKMRIPG--LGGKVM 165
Cdd:COG1638 104 -FDLPFLFRDYEHADKVLDGELGPELLEELEKKGLKVLGWWDNGFR--QLTtsKKPIRSPEDLKGLKIRVPGspVLAAMF 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      166 AKLGVNVQVLPGGEIYLALERGTIDAAEFTGP--YDdekLGLAKAAKHYYYPG-WWEPGPTLMalvNRKAWSDLPKEYQA 242
Cdd:COG1638 181 EALGANPVPMPFGEVYTALQTGVVDGQENPLSsiYS---AKLYEVQKYLTLTNhAYSPFVLVM---NKDFWDSLPPEQQA 254

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
7UG8_B      243 MFRTACYEAnlgmlSNYEW-----RNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADaDAGfKALLERWR 314
Cdd:COG1638 255 ALLEAAAEA-----AAYQRelareLEAEALAELKAAGVTVVELSPEDRAAFREAAKPVYDEWAE-EVG-AELLDAIR 324
PBP2_TRAP_DctP_like_1 cd13666
Substrate-binding component of an uncharacterized TRAP-type C4-dicarboxylate transport system; ...
 13-302 9.41e-32

Substrate-binding component of an uncharacterized TRAP-type C4-dicarboxylate transport system; the type 2 periplasmic-binding protein fold; This group includes a DctP subfamily of TRAP Transporters specific to C4-dicarboxylates such as succinate, malate and fumarate. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. This CD also included some eukaryotic homologs that have not been functionally characterized. TRAP transporters are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270384 [Multi-domain]  Cd Length: 303  Bit Score: 120.80  E-value: 9.41e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       13 WRMATSWPISLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFGTA 92
Cdd:cd13666   2 LRYASGLPPVNSAVSAAYEAFAEEVEERTGGELTFEIFWGGALLKAGETLQGVRDGVADIGQVVPLYFPAELPLQNVLYE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       93 VPFGLS--AQQQNTWLYYGGGNEDMNALFADFGAV-SFPAGNTGGQLGGwfKKPIQNLASLQGLKMRIPGLGGKVMAKLG 169
Cdd:cd13666  82 LPFAGSdpLAAAAAVTELYLTCPECQAEFERNNQVyLGGYATDPYVLLC--TKPVESLEDLKGKKIRAAGAWARWLEALG 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      170 VNVQVLPGGEIYLALERGTIDAAefTGPYDD-EKLGLAKAAKHYYYPGWWePGPTLMALVNRKAWSDLPKEYQAMFRTAC 248
Cdd:cd13666 160 AVPVNMPLTEVYEALQRGVLDCT--IGSASAlLAFKLYEVAPYVTLPGGG-AVAGAALVMNKDTWNSLPEEVREALLEAA 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
7UG8_B      249 YEANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADA 302
Cdd:cd13666 237 AEALAAYAEAYEADDEAALEEAEAAGVEIVEPSAELRAALAAFLPDDAAAWAEE 290
PBP2_TRAP_BpDctp6_7 cd13602
Substrate-binding domain of a pyroglutamic acid binding DctP subfamily of the tripartite ...
 12-314 1.08e-27

Substrate-binding domain of a pyroglutamic acid binding DctP subfamily of the tripartite ATP-independent periplasmic transporters; contains the type 2 periplasmic binding protein fold; DctP6 and DctP7 groups of the TRAP transporters that involved in pyroglutamic acid transport. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270320 [Multi-domain]  Cd Length: 300  Bit Score: 110.01  E-value: 1.08e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       12 RWRMATSWPISldTIYG-GAVTICQRVEEMSGGAFRIEPFAAGEI-VPGLEVLDAVQARSVECGHTASYYYIGKNPAFAf 89
Cdd:cd13602   1 TLDMAGEYPAG--NFHTqEAPFFAELVAEATGGKVKITVHPGGSLgLKGPEILRAVRDGAVDIGDVLLSYLAGDDPLFE- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       90 GTAVPF---GLSAQQQNTWLYYGGGNEDMNALFADF-GAVSFPAGntggqlGGWFKKPIQNLASLQGLKMRIPG-LGGKV 164
Cdd:cd13602  78 GDSLPFlatSYDEARKLYDAARPYLEKRLAERNAKLlYAVPWPPQ------GLFSKKPITSLADLKGLKIRTYDpTTAEF 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      165 MAKLGVNVQVLPGGEIYLALERGTIDAAeFTGPYDDEKLGLAKAAKHYY-YPGWWepgPTLMALVNRKAWSDLPKEYQAM 243
Cdd:cd13602 152 VEALGAAPVTLPFAEVVPALATGVIDCA-LTSTSSGVDGKWWEVTKHFYpINYGW---PLNMVAVNLDAWNALSPDVQAA 227

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
7UG8_B      244 FRTACYEANLGMLSNYEWRNSEALQRITRQGIKLERYGD-DILKAARSASAEIFQE-LADADAGFKALLERWR 314
Cdd:cd13602 228 LLEAAAELEDEGWALSAQETEEALACLRGNGMTVVEPSPaDLRQALKAAGEPVLPEwLKRAGPECAAILNAYR 300
PBP2_TRAP_Siap_TeaA_like cd13603
Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic ...
 13-314 1.47e-27

Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic transport system (SiaP) and related proteins; the type 2 periplasmic-binding protein fold; This subfamily includes the periplasmic-binding component of TRAP transport systems such as SiaP (a sialic acid binding virulence factor), TeaA (an ectoine binding protein), and an uncharacterized TM0322 from hyperthermophilic bacterium Thermotoga maritima. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270321 [Multi-domain]  Cd Length: 297  Bit Score: 109.54  E-value: 1.47e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       13 WRMATSWPISlDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFGTA 92
Cdd:cd13603   2 LKLAHVAPEG-SPYHKAAEKFAELVEEKSNGRIKVEIFPNGQLGGEREMLEGVQLGTIDMAVISTANLSNFVPEFGVLDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       93 vPFgL--SAQQQNTWLYyGGGNEDMNALFADFGAVSFPAGNTGgqlggwF------KKPIQNLASLQGLKMRIPG--LGG 162
Cdd:cd13603  81 -PF-LfrDYEHARKVLD-GPLGKELLEKLEEKGLKVLGYGENG------FrqitnnKPPIKSPEDLKGLKIRVPPspIYI 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      163 KVMAKLGVNVQVLPGGEIYLALERGTIDAAEftGPYDD-EKLGLAKAAK------HYYYPGWWepgptlmaLVNRKAWSD 235
Cdd:cd13603 152 ATFKALGANPTPMAFGEVYTALQQGVVDGQE--NPLSTiYSSKFYEVQKyltltnHVYSPGLL--------LMNKKFWDS 221

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
7UG8_B      236 LPKEYQAMFRTACYEANLGMLSNYEWRNSEALQRITRQGIKLerYGDDILKAARSASAEIFQELADADAGfKALLERWR 314
Cdd:cd13603 222 LPEELQKAILEAAKEAADYQRELAAEAEEEALEELKEKGVTV--TEPDDRAAFREAAAPVYDEFAKKGGG-KELIDAIQ 297
PBP2_TRAP_DctP1_3_4_like cd13601
Periplasmic substrate-binding component of uncharacterized TRAP-type C4-dicarboxylate ...
 14-305 1.23e-23

Periplasmic substrate-binding component of uncharacterized TRAP-type C4-dicarboxylate transporter subfamilies; the type 2 periplasmic-binding protein fold; This model includes uncharacterized DctP subfamilies of the TRAP Transporters. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270319 [Multi-domain]  Cd Length: 302  Bit Score: 98.93  E-value: 1.23e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       14 RMATSWPISLDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNP-------A 86
Cdd:cd13601   3 RVADSFPPQHPVSTEGTKPWMKRVEEATNGAVKFEHYPSGQLGKPKEQLDAVRSGVVDIGYIFPGYVSDKLPlngvvqlP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       87 FAFGTAVpfglsAQQQNTWLYYGGGNEDMnalFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRI-PGLGGKVM 165
Cdd:cd13601  83 GLGTTSV-----EGSAALWKATGGLLQQE---FEKNGVVPLFVHVLPPYQVLTKKPPVDSLADLKGLKLRSsGGALSLMA 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      166 AKLGVNVQVLPGGEIYLALERGTIDAaeFTGPYDDEK-LGLAKAAKHYYYPGWWEPGPTLMAlVNRKAWSDLPKEYQAMF 244
Cdd:cd13601 155 ESLGAVPVSMPAPEVYEALSRGVVDG--TLGPLASVIsYKLAEVVKYVTTNGNFGSGSFSYV-MNQDTWDALSDEQRKAL 231

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
7UG8_B      245 RTACYEANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQE-LADADAG 305
Cdd:cd13601 232 DEASGEAEAALAEALDAAVEELVAEAAAEGIEFVELSDEELAALEALLAAVTDDwIERLDAR 293
PBP2_TRAP_DctP10 cd13678
Substrate-binding component of Tripartite ATP-independent Periplasmic transporter DctP10; the ...
 13-301 5.17e-17

Substrate-binding component of Tripartite ATP-independent Periplasmic transporter DctP10; the type 2 periplasmic-binding protein fold; This subgroup includes TRAP transporter DctP10 and its similar proteins. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270396 [Multi-domain]  Cd Length: 300  Bit Score: 80.41  E-value: 5.17e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       13 WRMATSWPISlDTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPG--LEVLDAVQARSVECGHTASYYYIGKNPAFaFG 90
Cdd:cd13678   2 LKLSVPDGEN-SYWGQAAQKFAELVREKSNGRINIKVYPNGQLSGGdqTKAIEMLRNGSIDLAILSTINYSPFDPEF-NV 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       91 TAVPFGLSAQQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPG--LGGKVMAKL 168
Cdd:cd13678  80 FSLPFLFDDYDALDAYLNGEGGKELFEILEKKGVTPLGIGENGFRQITNSKRPITTPEDLKGLKLRVPGspLFIDFFRAL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      169 GVNVQVLPGGEIYLALERGTIDAAEFTgpyddekLGLAKAAKHY----YYPGWWEPGPTLMALVNRKAWSDLPKEYQAMF 244
Cdd:cd13678 160 GANPTAMNFSEVYTALQQGTVDGQENP-------VDVPNSAKFYevqkYVTLWNYVADPWVFGMNSKVWESLSEEDQAII 232

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
7UG8_B      245 RTACYEANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELAD 301
Cdd:cd13678 233 REAAVEAAQWQKANLAEEDGKILEELEKNGMEVNELTPEQIAAFKEASKPLYDKFKD 289
PBP2_TRAP_Dctp3_4 cd13665
Periplasmic substrate-binding component of TRAP-type C4-dicarboxylate transport system DctP3 ...
 34-313 7.84e-17

Periplasmic substrate-binding component of TRAP-type C4-dicarboxylate transport system DctP3 and DctP4; the type 2 periplasmic-binding protein fold; This group includes uncharacterized DctP3 and DctP 4 subfamilies of TRAP Transporters specific to C4-dicarboxylates such as succinate, malate and fumarate. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. This CD also included some eukaryotic homologs that have not been functionally characterized. TRAP transporters are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270383 [Multi-domain]  Cd Length: 302  Bit Score: 79.55  E-value: 7.84e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       34 CQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPaFAFGTAVPFGLSAQQQNTWLYYGggNE 113
Cdd:cd13665  23 AEEVEEASGGRVTVEIYPGGTLGKPPQQYDLVRDGVADIGWTVPGYTPGRFP-LTEVVELPFLAPSAEAGSVALWE--YE 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      114 DMNALFADFGAVSFPAGNTGGqlGGWF---KKPIQNLASLQGLKMRIPG-LGGKVMAKLGVNVQVLPGGEIYLALERGTI 189
Cdd:cd13665 100 YEGALADEFKDVKVLALFTHG--PGQLhtkKPVVRSLEDLKGLKIRVPGgTAADILEALGATPVGMPAPDVYEALSKGVI 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      190 DAAefTGPYDDEK-LGLAKAAKHYYYPGwwEPGPTLMALV-NRKAWSDLPKEYQAMFRTACYEAnlgmlsnYEWRNSEAL 267
Cdd:cd13665 178 DGA--LLPWEALKsFKLAEVTKYHTEPG--GLYTTSFAVVmNKDKYDSLPDDLQAVIDEVSGEE-------LSRLAGKAW 246

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
7UG8_B      268 QRITRQGIklerygddilKAARSASAEIFQ----ELADADAGFKALLERW 313
Cdd:cd13665 247 DDADAAGR----------EAARAAGVTIIElsdaEIARWDEALAPVIDAW 286
PBP2_TRAP_DctP1 cd13667
Periplasmic substrate-binding component of an uncharacterized TRAP-type C4-dicarboxylate ...
 37-310 1.66e-14

Periplasmic substrate-binding component of an uncharacterized TRAP-type C4-dicarboxylate transport system DctP1; contains the type 2 periplasmic-binding protein fold; This group includes an uncharacterized DctP1 subfamily of the TRAP Transporters. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270385 [Multi-domain]  Cd Length: 295  Bit Score: 72.76  E-value: 1.66e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       37 VEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFGTAVPFGLSAQQQNtwlyygGGNEDMN 116
Cdd:cd13667  25 VNEGGGGVVQINVVGGPEAIPPFEQGNAVRNGVVDIAYSPGSFYAGLVPEADALKLSNVTAAELRAN------GGFDLMN 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      117 ALFADFGAVSFPAGNTGG-QLGGWFKKPIQNLASLQGLKMRIPGLGGKVMAKLGVNVQVLPGGEIYLALERGTIDAAEFT 195
Cdd:cd13667  99 QIHQEKMNVKYLARVDSGvPYHIYTNKEPSDKLDLTGKKLRSSPVYRAFFEALGAQPVSTPPGEVYTALERGVVDGYGWP 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      196 --GPYDdekLGLAKAAKHYYYPGWWEpgPTLMALVNRKAWSDLPKEYQAMFRTACYEANlgmLSNYEWRNSEALQRITRQ 273
Cdd:cd13667 179 iiGIFD---LGWQEFTKYRVEPGFYQ--TDVSVIMNLDKWNSLSPEAQAILQDAAIEAE---GQSAGWAKAKREAEFAKQ 250

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
7UG8_B      274 ---GIKLERY----GDDILKAARSASAEIFQELADADAG-FKALL 310
Cdd:cd13667 251 aeaGIETVSLegeaAEKFLGRAYDAGWARMMEQAPETAAkLKPLF 295
PBP2_TRAP_SBP_like_3 cd13671
Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic ...
 35-312 2.63e-14

Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic transporter family; the type 2 periplasmic-binding protein fold; This subfamily includes uncharacterized periplasmic substrate-binding proteins similar to TRAP transport systems such as SiaP (a sialic acid binding virulence factor) and TeaA (an ectoine binding protein). TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270389 [Multi-domain]  Cd Length: 296  Bit Score: 72.20  E-value: 2.63e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       35 QRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAfgtavPFGL-----SAQQQNTWLYYG 109
Cdd:cd13671  23 ELVKERTNGRITIEVYPNGQLGDEKETIEQVQNGAIDMARVSASPLENFVPEFG-----VFSLpylfrSVEHMYKVLDGE 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      110 GGNEDMNAL---------FADFGAVSFpaGNTggqlggwfKKPIQNLASLQGLKMRIPG--LGGKVMAKLGVNVQVLPGG 178
Cdd:cd13671  98 VGDELLDSLedsgfvglgWYDAGARSF--YTT--------KPPINTPADLKGLKIRVQEsdVMIDMVEALGASPTPMPYG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      179 EIYLALERGTIDAAE--FTGpYDDEKLGlaKAAKHYYYPGWWePGPTLMaLVNRKAWSDLPKEYQAMFRTACYEAnlGML 256
Cdd:cd13671 168 EVYTALQTGVIDGAEnnEPS-YYSSKHY--EVAKYFSLTEHL-RIPDVL-VMSKATWDSLSPEDQEIIKEAAKES--AEY 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
7UG8_B      257 SNYEWRNSEALQRitrqgIKLERYGDDILKAARSASAEIFQELAD---ADAGFKALLER 312
Cdd:cd13671 241 QRELWAESEEEAR-----AKAEEAGVEINEVDKAPFQEAVKPLYDeylKNPEYKDLIER 294
PBP2_TRAP_SBP_like_4 cd13680
Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic ...
 36-309 1.28e-13

Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic transporter family; the type 2 periplasmic-binding protein fold; This subfamily includes uncharacterized periplasmic substrate-binding proteins similar to TRAP transport systems such as SiaP (a sialic acid binding virulence factor) and TeaA (an ectoine binding protein). TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270398 [Multi-domain]  Cd Length: 300  Bit Score: 70.41  E-value: 1.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       36 RVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFGTaVPFGLSAQQQNTWLYYGGGNEDM 115
Cdd:cd13680  24 EVEERSKGELKVQVYPSAQLYKDNEQPQAVASGALEMGVAPLAYWGGTVPEVNVFL-MPFLFPSYEAARKALDSPFRKAL 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      116 NALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPG-LGGKVMAKLGVNVQVLPGGEIYLALERGTIDAAeF 194
Cdd:cd13680 103 DGAIEKKGVKVLAWADYGGAQFSSKKKPLVSPEDFKGLKIRGYGkAFDEMLKALGASPVSMPGSEVYAALQTGTVDAA-M 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      195 TGP--------YDDEKLGLAKAAKHYYYPgwwepgptlmALVNRKAWSDLPKEYQAMFRTACYEANLGMLSNYEWRNSEA 266
Cdd:cd13680 182 TGStaavsrklYEVAKYLTVTNASWFEFE----------VVVNSKWFDGLSEEQQAALTEAAAEAEKFLREAAKKIDADA 251

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
7UG8_B      267 LQRITRQGIKLERYGDDILK----AARSASAEIFQelADADAGFKAL 309
Cdd:cd13680 252 AKVLEDAGMKVVVLTAEEIKawqeAAAPVVDKFFA--AAGEGGQKLL 296
PBP2_TRAP_YiaO_like cd13679
Substrate-binding domain of 2,3-diketo-L-gulonate-binding Tripartite ATP-independent ...
 35-301 4.16e-13

Substrate-binding domain of 2,3-diketo-L-gulonate-binding Tripartite ATP-independent Periplasmic transport system and related proteins; the type 2 periplasmic-binding protein fold; This subfamily includes the solute receptor protein YiaO of TRAP transport system. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270397 [Multi-domain]  Cd Length: 298  Bit Score: 68.77  E-value: 4.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       35 QRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFgTAVPFGLSAQQQNTWLYYGGGNED 114
Cdd:cd13679  23 ELVEERSGGRIKVKVFPSAQLGNDTQMISALQGGTLEMTVVSTGPLVGFVKEFAV-FDLPFLFNSEEEADAVLDGPVGRK 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      115 MNALFAdfgavsfPAGNTGgqLGGW---F------KKPIQNLASLQGLKMRipglggkVMAK---------LGVNVQVLP 176
Cdd:cd13679 102 LLAKLE-------GKGLKG--LAFWengFrhltnsKRPVNTPEDLKGLKIR-------TMPNpvhidtfkaLGANPTPMP 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      177 GGEIYLALERGTIDAAEftGPYDdeklgLAKAAK------------HYYYPgwwepgptLMALVNRKAWSDLPKEYQAMF 244
Cdd:cd13679 166 FSELYTALEQGAIDGQE--NPLS-----TIYSSKfyevqkylsltnHVYSP--------LVLVASKKFWDSLSPEDQKLL 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
7UG8_B      245 RTACYEAnlgmlSNYEW-----RNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELAD 301
Cdd:cd13679 231 QEAAAEA-----ALYQRelnreEEAKALAELKEKGMQVNELPDAELAKFREAVKPVVDKYKA 287
TRAP_S1 NF037995
TRAP transporter substrate-binding protein DctP; Proteins of this family are members of the ...
 141-279 1.59e-12

TRAP transporter substrate-binding protein DctP; Proteins of this family are members of the superfamily of Tripartite ATP-independent Periplasmic Transporter (TRAP-T). They transport hydrophobic substrates, usually lipoprotein.


Pssm-ID: 468304 [Multi-domain]  Cd Length: 271  Bit Score: 66.85  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       141 KKPIQNLASLQGLKMRIPG---LGGKVMAKLGVNVQVLPGGEIYLALERGTIDAAEFTgPYDDEKLGLAKAAKHYYYPGW 217
Cdd:NF037995 124 KKPIRSPADLKGIKIWRTMgdpIHIAAFKALGANPVPLPIGEVLTALQTGVVDGAENP-PLGAVALQWYEVAKYMTDLPH 202

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
7UG8_B       218 -WEPGPTLMALvnrKAWSDLPKEYQAMFRTACYEANLGMLSNYEWRNSEALQRITRQGIKLER 279
Cdd:NF037995 203 aPVPGGLVISK---KAWNKLPPEYQAILRKAAAEAGEELRALVREDNAEALAKMKKAGVTVIE 262
PBP2_TRAP_TM0322_like cd13669
Periplasmic component of TRAP-type C4-dicarboxylate transport system TM0322 from Thermotoga ...
 141-299 3.08e-12

Periplasmic component of TRAP-type C4-dicarboxylate transport system TM0322 from Thermotoga maritima and similar proteins; the type 2 periplasmic binding protein fold; This subgroup includes the hyperthermophilic bacterium Thermotoga maritima TRAP-type C4-dicarboxylate transport system TM0322 and its closely related proteins. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270387 [Multi-domain]  Cd Length: 296  Bit Score: 66.43  E-value: 3.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      141 KKPIQNLASLQGLKMRIPG--LGGKVMAKLGVNVQVLPGGEIYLALERGTIDAAEftGPY---DDEKLglAKAAKHYYyp 215
Cdd:cd13669 128 NKPVKTPADLKGLKIRVPGnpIWIETIEALGATPTPMPWSEVYTALQQGVIDGAE--NPLptlYGGKL--YEVAKYIS-- 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      216 gwwEPGPTLM---ALVNRKAWSDLPKEYQAMFRTACYEANLGMLSNYEWRNSEALQRITRQGIKlerYGDDILKAARSAS 292
Cdd:cd13669 202 ---LTGHILLisgLVVSAKWFDSLPEEYQKILVEEADKAGEYASELTLEEEEEYLKKLKEEGVT---VIEVDLEAFKKAA 275


                ....*..
7UG8_B      293 AEIFQEL 299
Cdd:cd13669 276 EPVYEKL 282
PBP2_TRAP_SBP_like_6 cd13677
Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic ...
 24-312 3.43e-12

Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic transporter family; the type 2 periplasmic-binding protein fold; This subfamily includes uncharacterized periplasmic substrate-binding proteins similar to TRAP transport systems such as SiaP (a sialic acid binding virulence factor) and TeaA (an ectoine binding protein). TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270395 [Multi-domain]  Cd Length: 304  Bit Score: 66.16  E-value: 3.43e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       24 DTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVE-----CGHTASYYyigkNPAFAFGtaVPFGLS 98
Cdd:cd13677  15 NPVHAAALVFKNLVESRSNGRVAVEIYPGGQLGSEKECMEQVQKGVIQsfiatVGGMASLY----PPIQVLD--LPFAFP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       99 AQQQnTWLYYGGgnEDMNALFADFgavsfpAGNTGGQL------GGWF-----KKPIQNLASLQGLKMRIPGLGGKV--M 165
Cdd:cd13677  89 NDRV-AYAVFDG--PFGKALAKDI------LEKTGLRLlgvgdtGGFRnftnsKRPIKTPADMKGLKIRTMPLPSQQalV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      166 AKLGVNVQVLPGGEIYLALERGTIDAaEFTGPYD------DEKLGLAKAAKHYYYPGWWepgptlmaLVNRKAWSDLPKE 239
Cdd:cd13677 160 KALGASPTPIPWGELYTALQTGVVDG-QMNPIPDiifaklDEVQKYLTLDNHLYSPYFW--------VMNGDFFNSLPEE 230

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
7UG8_B      240 YQAMFRTACYEANLGMLSNYEWRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADADAGfKALLER 312
Cdd:cd13677 231 EQRIVLDAAEEAVVASRGRPKAQEDRGLEFLREKGGEVYTPTPEEREAFREAAQPAYDWWLEETYG-EEWLEL 302
dctP TIGR00787
tripartite ATP-independent periplasmic transporter solute receptor, DctP family; TRAP-T ...
 36-274 7.01e-12

tripartite ATP-independent periplasmic transporter solute receptor, DctP family; TRAP-T (Tripartite ATP-independent Periplasmic Transporter) family proteins generally consist of three components, and these systems have so far been found in Gram-negative bacteria, Gram-postive bacteria and archaea. The best characterized example is the DctPQM system of Rhodobacter capsulatus, a C4 dicarboxylate (malate, fumarate, succinate) transporter. This model represents the DctP family, one of at least three major families of extracytoplasmic solute receptor for TRAP family transporters. Other are the SnoM family (see pfam03480) and TAXI (TRAP-associated extracytoplasmic immunogenic) family. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129869 [Multi-domain]  Cd Length: 257  Bit Score: 64.70  E-value: 7.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B         36 RVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFgTAVPFGLSAQQQNTWLYYGGGNEDM 115
Cdd:TIGR00787  21 LVNEKTNGEIKISVFPSSQLGSDRAMLEALQGGALDMTAPSSSKFGPLVPELAV-FDLPFLFRDYNHVHKVLDGEVGKAL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B        116 NALFADFGAVSFPAGNTGGQLGGWFKKPIQNLASLQGLKMRIPGlgGKVMAK----LGVNVQVLPGGEIYLALERGTIDA 191
Cdd:TIGR00787 100 KKSLEKKGLKGLAYWDNGFRQFTSSKKPITKPEDLKGLKIRIPN--SPMNEAqfkaLGANPEPMAFSEVYTALQTGVVDG 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B        192 AEFTgpyddekLGLAKAAKHYYYPGW-------WEPGPTLMalvNRKAWSDLPKEYQAMFRTACYEANLGMLSNYEWRNS 264
Cdd:TIGR00787 178 QENP-------LSNVYSSKFYEVQKYlsmtnhgYLGYLVVV---NKAFWKSLPPDLQAVVKEAAKEAGEYQRKLSAEDEQ 247

                         250
                  ....*....|
7UG8_B        265 EALQRITRQG 274
Cdd:TIGR00787 248 KLIEKFKKQG 257
PBP2_TRAP_DctP_like_2 cd13605
Substrate-binding component of uncharacterized Tripartite ATP-independent Periplasmic ...
 35-312 1.12e-10

Substrate-binding component of uncharacterized Tripartite ATP-independent Periplasmic transporter; the type 2 periplasmic-binding protein fold; This family represents the TRAP Transporters that are specific to various ligands, including sialic acid (N-acetyl neuraminic acid), glutamate, ectoine, xylulose, C4-dicarboxylates such as succinate, malate and fumarate, and keto acids such as pyruvate and alpha-ketobutyrate. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. This CD also included some eukaryotic homologs that have not been functionally characterized. TRAP transporters are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270323 [Multi-domain]  Cd Length: 303  Bit Score: 61.61  E-value: 1.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       35 QRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFAFgTAVP--FGLSAQQQNTWLYYGGGN 112
Cdd:cd13605  23 EDVEERSAGRLKVEVFPSAQLYKDKDVVRALAQGAVEMAVPGTWQLSRIDPEYGL-FLLPmfFGATAMQTHRFAQGPLGD 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      113 EdMNALFADFGAVSFPAGNTGGQLGGWFK-KPIQNLASLQGLKMRIPGLGG--KVMAKLGVNVQVLPGGEIYLALERGTI 189
Cdd:cd13605 102 E-LLTRIERKLRVQVLGRWRDGGGYVFFTdKAVDSPEDLAGLKIRVAGGAAnvARLRAFGASPVSIPASDLPLALQQGTI 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      190 D----AAEFTGPyddekLGLAKAAKHYYYpgwwEPG---PTLMALVNRKAWSDLPKEYQAMFRTAcyeANLGMLSNYE-- 260
Cdd:cd13605 181 DgiltTPETVAS-----ARLWESGIRFVF----EDRqyfAQYVPVVSDRFWAKLPEEQRQVLRET---WNEIIAQQRAha 248

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
7UG8_B      261 -WRNSEALQRITRQGIKLERYGDDILKAARSASAEIFQELADADAGFKALLER 312
Cdd:cd13605 249 aEAQAEAREQMRANGVTITVPPPAELADWRERLLLLQPEVVRKLGIDPELIKQ 301
PBP2_TRAP_Siap cd13672
Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic ...
 24-312 1.76e-10

Substrate-binding domain of a sialic acid binding Tripartite ATP-independent Periplasmic transport system (SiaP); the type 2 periplasmic-binding protein fold; This subfamily represents the periplasmic-binding component of TRAP transport system SiaP, a sialic acid binding virulence factor. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270390 [Multi-domain]  Cd Length: 295  Bit Score: 61.11  E-value: 1.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       24 DTIYGGAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVE-----CGHTASYYyigknPAFA-FGTAVPFGL 97
Cdd:cd13672  12 SPEYKAAEAFAEEVEEKSGGKITVQVYPSSQLGSERDMLEQLSSGSLDmtyagSGFFGKFY-----PPASvFEAPYLFRD 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       98 SAQQQNtwlYYGGgnEDMNALFADFGAVSfpaGNTggQLGGWF--------KKPIQNLASLQGLKMRIPG----LggkVM 165
Cdd:cd13672  87 YDHMQK---VLNS--DLGAELFDKLDEKL---GVR--ILGSAYygtrqvtsNKPINTPADMKGLKLRVPNapsyL---AL 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      166 AK-LGVNVQVLPGGEIYLALERGTIDAAEftGPyddekLGLAKAAKHYyypgwwEPGP----------TLMALVNRKAWS 234
Cdd:cd13672 154 AKaLGANPTPMAFSEVYLALQQGAVDGQE--NP-----LPTIKAAKFY------EVQKylaltghivdDQLIVVSEDTWQ 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      235 DLPKEYQAMFRTACYEANlgmlsnyEWRNSEA-------LQRITRQGIKLERygdDILKAARSASAEIFQELaDADAGfK 307
Cdd:cd13672 221 KLTEEQQAIVTDAAEEAA-------EYANKLVideeaelVEFFKEQGVTVTE---PDLEAFREAAAPYYLEF-LAEWG-E 288


                ....*
7UG8_B      308 ALLER 312
Cdd:cd13672 289 GLYKR 293
PBP2_TRAP_Tp0957_like cd13670
Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic ...
 137-301 1.18e-09

Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic transporter family; the type 2 periplasmic-binding protein fold; This subfamily includes the putative periplasmic substrate-binding protein Tp0957 from Treponema pallidum, which is similar to TRAP transport systems such as SiaP (a sialic acid binding virulence factor) and TeaA (an ectoine binding protein). TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270388 [Multi-domain]  Cd Length: 298  Bit Score: 58.37  E-value: 1.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      137 GGWF----KKPIQNLASLQGLKMRIPGLG---GKVMAKLGVNVQVLPGGEIYLALERGTIDAAeFTGPYDDEKLGLAKAA 209
Cdd:cd13670 118 QGFDyifsKKPVATLEDLKKQKIWTWEGGpveEEALKALGASPVPLPLPEVLTSLQTGLIDAV-IAPPLWALALQWYTKV 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      210 KhYYYPGWWEPGPTLMaLVNRKAWSDLPKEYQAMFRTACYEA----NLGMLSNyewrNSEALQRITRQGIKLERYGDDIL 285
Cdd:cd13670 197 K-YVNDLPIRYSPGAI-VISKKAWNKLPAEYQEAVREARAKAfkrlNAKVRED----NEKALAAMKKYGLKVVKLSPEEL 270

                       170
                ....*....|....*.
7UG8_B      286 KAARSASAEIFQELAD 301
Cdd:cd13670 271 EEWRKAARPVWEELAG 286
PBP2_TRAP_UehA_TeaA cd13668
Periplasmic substrate-binding component of osmoregulatory TRAP transporters TeaA and UehA; the ...
 18-312 2.07e-09

Periplasmic substrate-binding component of osmoregulatory TRAP transporters TeaA and UehA; the type 2 periplasmic-binding protein fold; This subfamily includes the periplasmic-binding component of the ectoine-specific TRAP transporters TeaA from Halomonas elongata and UehA from Ruegeria pomeroyi. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270386 [Multi-domain]  Cd Length: 305  Bit Score: 58.04  E-value: 2.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       18 SWPISLDTIYGG-----AVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVE-----CGHTASYyyIGKNPAF 87
Cdd:cd13668   1 TWRFALEEIEGDvqdvyAQEFKEEIEEKSDGDVTVDIYPYGTLGDSEDIVEQTQNGAIQfvftsPGFLGSL--VPEAQVF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       88 AfgtaVPFGLSAQQQ-NTWLYYGGG--NEDMNALFADFGAV---SFPAGN---TGgqlggwfKKPIQNLASLQGLKMRIp 158
Cdd:cd13668  79 S----LPYLLPDDPEvNAKVLNESKaiNEMLAKAYEKQGLKllaMFPEGWmvwTA-------NKPIRTPADFDGFKIRT- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      159 gLGGKVMAK----LGVNVQVLPGGEIYLALERGTIDAAEfTGPYDDEKLGLAKAAKHYYYPGwwePGPTLMA-LVNRKAW 233
Cdd:cd13668 147 -MTSPLLVEtykaYGADPTPLPYGEVYGGLQLGMIDGQE-NPIFAIEEMKFYEVQDYLTLAG---HAPFVATvVANKDFY 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      234 SDLPKEYQAMFRTACYEANLGMLSNYEWRNSEALQRI--TRQGIKLERYGDDILKAARSASA---EIFQELADADAgfKA 308
Cdd:cd13668 222 DSLPEEDQKMVREAADEAIDWAFEMQQELNDERLEKIkeSSPDIEVIELTEEEREAFKERAKpvrDKYIEMTGESG--KE 299


                ....
7UG8_B      309 LLER 312
Cdd:cd13668 300 ILDQ 303
PBP2_TRAP_SBP_like_5 cd13675
Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic ...
 22-312 2.45e-09

Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic transporter family; the type 2 periplasmic-binding protein fold; This subfamily includes uncharacterized periplasmic substrate-binding proteins similar to TRAP transport systems such as SiaP (a sialic acid binding virulence factor) and TeaA (an ectoine binding protein). TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270393 [Multi-domain]  Cd Length: 296  Bit Score: 57.65  E-value: 2.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       22 SLDTIYG-GAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFA-FGtaVPFGLSA 99
Cdd:cd13675   9 AEDSHYGlAAEAFAEEVEEKTNGRVKVEIFPNSQLGGERELIEGLQLGTVDMAVVSTGPLANFVPEFAvFD--LPFLFRD 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      100 QQQNTWLYYGGGNEDMNALFADFGAVSFPAGNTGgqlggwF------KKPIQNLASLQGLKMRipglggkVMAK------ 167
Cdd:cd13675  87 REHAYKVLDGEIGQELLAKLSDVGLKGLAWWENG------FrnltnsKRPVNTPDDLKGLKIR-------TMENpihiaa 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      168 ---LGVNVQVLPGGEIYLALERGTIDAAEftGPY---DDEKLG-----LAKAAkHYYypgwwepGPTLMaLVNRKAWSDL 236
Cdd:cd13675 154 fraLGADPTPMAWTEVFTALQQGTIDGQE--NPItviYSSKLYevqkyLSLTG-HVY-------SPAVL-LMSPDVWDSL 222

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
7UG8_B      237 PKEYQAMFRTACYEANLGMLSNYEWRNSEALQRITRQGIKLERygDDILKAARSASAEIFQELadADAGFKALLER 312
Cdd:cd13675 223 SDEQQAIIREAAKEAAEYERALVDEMEEEALETLKEEGMEVVE--PDDKAAFREAVAPVYEKY--EDQFGKDLLDR 294
PBP2_TRAP_SBP_like_1 cd13674
Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic ...
 21-274 3.09e-09

Uncharacterized substrate-binding protein of the Tripartite ATP-independent Periplasmic transporter family; the type 2 periplasmic-binding protein fold; This subfamily includes uncharacterized periplasmic substrate-binding proteins similar to TRAP transport systems such as SiaP (a sialic acid binding virulence factor) and TeaA (an ectoine binding protein). TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process and a smaller membrane of unknown function. The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270392 [Multi-domain]  Cd Length: 299  Bit Score: 57.29  E-value: 3.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       21 ISLDTIYGGAVTI-CQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVecgHTASyyyigknPAFA-FGTAVPfgls 98
Cdd:cd13674   8 VAENTPKGLAANKfAELVEERSGGKVKVEVYPNSQLYGDIEELEALKLGDV---QMIA-------PSLSkLSLYVP---- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       99 aqqqnTWLYYgggneDMNALFADFGAV-SFPAGNTGGQ------------LGGW---FK------KPIQNLASLQGLKMR 156
Cdd:cd13674  74 -----EFQVF-----DLPFLFKDMEAVhRFTDGEVGDKllrsleekglvgLAFWdngFKqftankPLIRTPEDLKGLKFR 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      157 IPGLG--GKVMAKLGVNVQVLPGGEIYLALERGTIDAAE--FTGPYDDeklGLAKAAKH-----YYYPGWwepgptlMAL 227
Cdd:cd13674 144 IMGSDvlEAQFEALGATPVPLPFSEVYQALQTGVVDGQEntWSNIYSQ---KFYEVQKYltvsnHGYLGY-------AVI 213

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
7UG8_B      228 VNRKAWSDLPKEYQAMFRTACYEANlgMLSNY--EWRNSEALQRITRQG 274
Cdd:cd13674 214 TSEQFWDSLPPEDRKLLEDALKEAT--EYENElaAELNERDLERLKQAG 260
PBP2_TRAP_DctP2_like cd13676
Substrate-binding component of Tripartite ATP-independent Periplasmic transporter DctP2 and ...
 29-303 1.14e-07

Substrate-binding component of Tripartite ATP-independent Periplasmic transporter DctP2 and related proteins; the type 2 periplasmic-binding protein fold; This subgroup includes TRAP transporter DctP2 and its similar proteins. TRAP transporters are a large family of solute transporters ubiquitously found in bacteria and archaea. They are comprised of a periplasmic substrate-binding protein (SBP; often called the P subunit) and two unequally sized integral membrane components: a large transmembrane subunit involved in the translocation process (the M subunit) and a smaller membrane of unknown function (the Q subunit). The driving force of TRAP transporters is provided by electrochemical ion gradients (either protons or sodium ions) across the cytoplasmic membrane, rather than ATP hydrolysis. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270394 [Multi-domain]  Cd Length: 297  Bit Score: 52.61  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B       29 GAVTICQRVEEMSGGAFRIEPFAAGEIVPGLEVLDAVQARSVECGHTASYYYIGKNPAFA-FGtaVPFgL--SAQQQNTW 105
Cdd:cd13676  17 AAKAFKEYVEEKTGGRVKVEIFPSGQLGGEREMLEGVQLGTIDMGVIGTGPLSGFVPKVGvFD--LPF-LfpSREAAYKV 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      106 LYyGGGNEDMNALFADFGAVSFPAGNTGgqlggwF------KKPIQNLASLQGLKMRipglggkVM---------AKLGV 170
Cdd:cd13676  94 LD-GELGQELAELMEKKGLKGLAYWENG------FrhftnnKRPIKTPADMKGLKIR-------VMespvqiatfKALGA 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7UG8_B      171 NVQVLPGGEIYLALERGTIDAAEftGPyddekLGLAKAAK------------HYYYPgwwepgptLMALVNRKAWSDLPK 238
Cdd:cd13676 160 SPTPIAFGELYTALQQGVVDGQE--NP-----LALIVSSKfyevqkylsltgHVYTP--------AVLIINKDTWNSLSD 224

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
7UG8_B      239 EYQAMFRTACYEA---NLGMLSNYEwrnSEALQRITRQGIKLERygDDILKAARSASAEIFQELADAD 303
Cdd:cd13676 225 DQQKIIQEAAKEArdvQRELNAEKE---NEGLEKLKAKGMEINE--LTDKEAFREAVQPVYDKYEDEV 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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