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Conserved domains on  [gi|2557041142|pdb|7YKM|A]
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Chain A, DciA DUF721 domain

Protein Classification

DUF721 domain-containing protein( domain architecture ID 10526205)

uncharacterized DUF721 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DciA pfam05258
Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members ...
 13-99 5.41e-22

Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members such as DciA (dna[CI] antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional analysis revealed that DciA is essential for replication initiation and protein depletion resulted in a blockage of the initiation of replication after the formation of the open complex.


:

Pssm-ID: 461606 [Multi-domain]  Cd Length: 88  Bit Score: 81.95  E-value: 5.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7YKM_A         13 STLMGATLGKGKLGYGVQRARALLLWPQAVGPEIARMTRPRSVQGGTLFVEVRDSAAAHHLTMQRHHFLKRLNELLGAGq 92
Cdd:pfam05258   3 GDLLGRLLSARGLQKALALARLLQAWPEIVGPELAGHTRPLSLRDGTLVVEVDSGAWATQLRYLKPQLLERLNARLGRE- 81


                  ....*..
7YKM_A         93 EVSELRF 99
Cdd:pfam05258  82 VVRRIRF 88
 
Name Accession Description Interval E-value
DciA pfam05258
Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members ...
 13-99 5.41e-22

Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members such as DciA (dna[CI] antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional analysis revealed that DciA is essential for replication initiation and protein depletion resulted in a blockage of the initiation of replication after the formation of the open complex.


Pssm-ID: 461606 [Multi-domain]  Cd Length: 88  Bit Score: 81.95  E-value: 5.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7YKM_A         13 STLMGATLGKGKLGYGVQRARALLLWPQAVGPEIARMTRPRSVQGGTLFVEVRDSAAAHHLTMQRHHFLKRLNELLGAGq 92
Cdd:pfam05258   3 GDLLGRLLSARGLQKALALARLLQAWPEIVGPELAGHTRPLSLRDGTLVVEVDSGAWATQLRYLKPQLLERLNARLGRE- 81


                  ....*..
7YKM_A         93 EVSELRF 99
Cdd:pfam05258  82 VVRRIRF 88
COG5512 COG5512
Predicted nucleic acid-binding protein, contains Zn-ribbon domain (includes truncated ...
 9-100 7.15e-22

Predicted nucleic acid-binding protein, contains Zn-ribbon domain (includes truncated derivatives) [General function prediction only];


Pssm-ID: 444263  Cd Length: 116  Bit Score: 82.57  E-value: 7.15e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7YKM_A        9 PLDMSTLMGATLGKGKLGYGVQRARALLLWPQAVGPEIARMTRPRSVQGGTLFVEVRDSAAAHHLTMQRHHFLKRLNELL 88
Cdd:COG5512   2 PQSLGSLLGRLVKQRGWEEQLAVGRVLGRWPEIVGPEVAAHTRPVSIEDGVLTVAASSTAWATQLRLLRPQLLAKLNEEL 81

                        90
                ....*....|..
7YKM_A       89 GAGqEVSELRFS 100
Cdd:COG5512  82 GEG-VVTDIRFS 92
 
Name Accession Description Interval E-value
DciA pfam05258
Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members ...
 13-99 5.41e-22

Dna[CI] antecedent, DciA; This family contains several actinomycete proteins. Family members such as DciA (dna[CI] antecedent) found in Pseudomonas aeruginosa, has been shown to share a common function with DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis), acting as a replicative helicase. Furthermore, functional analysis revealed that DciA is essential for replication initiation and protein depletion resulted in a blockage of the initiation of replication after the formation of the open complex.


Pssm-ID: 461606 [Multi-domain]  Cd Length: 88  Bit Score: 81.95  E-value: 5.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7YKM_A         13 STLMGATLGKGKLGYGVQRARALLLWPQAVGPEIARMTRPRSVQGGTLFVEVRDSAAAHHLTMQRHHFLKRLNELLGAGq 92
Cdd:pfam05258   3 GDLLGRLLSARGLQKALALARLLQAWPEIVGPELAGHTRPLSLRDGTLVVEVDSGAWATQLRYLKPQLLERLNARLGRE- 81


                  ....*..
7YKM_A         93 EVSELRF 99
Cdd:pfam05258  82 VVRRIRF 88
COG5512 COG5512
Predicted nucleic acid-binding protein, contains Zn-ribbon domain (includes truncated ...
 9-100 7.15e-22

Predicted nucleic acid-binding protein, contains Zn-ribbon domain (includes truncated derivatives) [General function prediction only];


Pssm-ID: 444263  Cd Length: 116  Bit Score: 82.57  E-value: 7.15e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7YKM_A        9 PLDMSTLMGATLGKGKLGYGVQRARALLLWPQAVGPEIARMTRPRSVQGGTLFVEVRDSAAAHHLTMQRHHFLKRLNELL 88
Cdd:COG5512   2 PQSLGSLLGRLVKQRGWEEQLAVGRVLGRWPEIVGPEVAAHTRPVSIEDGVLTVAASSTAWATQLRLLRPQLLAKLNEEL 81

                        90
                ....*....|..
7YKM_A       89 GAGqEVSELRFS 100
Cdd:COG5512  82 GEG-VVTDIRFS 92
COG5389 COG5389
Uncharacterized conserved protein, DUF721 domain [Function unknown];
2-89 8.74e-07

Uncharacterized conserved protein, DUF721 domain [Function unknown];


Pssm-ID: 444152  Cd Length: 163  Bit Score: 44.47  E-value: 8.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7YKM_A        2 TRSRRSGPLDMSTLMGATLGKGKLGYGVQRARALLLWPQAVGPEIARMTRPRSVQ-------GGTLFVEVrDSAAAHHLT 74
Cdd:COG5389   4 RRRRRRGFRPLSDLVPGVIRPALRKRGFASSRLLTHWPEIVGEDLARITRPEKISwprgrgeGATLTLRV-EGAAALELQ 82

                        90
                ....*....|....*
7YKM_A       75 MQRHHFLKRLNELLG 89
Cdd:COG5389  83 HQSPQIIERVNAFFG 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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