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Conserved domains on  [gi|2222681130|pdb|7Z79|D]
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Chain D, Aminotransferase, class 4

Protein Classification

aminotransferase class IV( domain architecture ID 1051)

aminotransferase class IV is a pyridoxaL 5'-phosphate dependent enzyme (PLPDE), similar to Staphylococcus D-alanine aminotransferase

Gene Ontology:  GO:0030170
PubMed:  31989227

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLPDE_IV super family cl00224
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 27-299 2.75e-92

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


The actual alignment was detected with superfamily member cd01558:

Pssm-ID: 444764 [Multi-domain]  Cd Length: 270  Bit Score: 275.25  E-value: 2.75e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       27 YVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGMR 106
Cdd:cd01558   1 YLNGEYVPREEAKVSVFDRGFLFGDGVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIRELVAKNEGG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      107 DG-AHARlmVTRGVKKTPNQDPRFIigGATVVCVAEH-KVVTPEAKRNGLKLFTStlrcsgPDVFDLRLN--SHSRLNLI 182
Cdd:cd01558  81 EGdVYIQ--VTRGVGPRGHDFPKCV--KPTVVIITQPlPLPPAELLEKGVRVITV------PDIRWLRCDikSLNLLNNV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      183 QALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWTS-SGRYCFNGITRATVVRLAREAGIPVHEGDFTLAEVYA 261
Cdd:cd01558 151 LAKQEAKEAGADEAILLDADGLVTEGSSSNVFIVKNGVLVTPpLDNGILPGITRATVIELAKELGIPVEERPFSLEELYT 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
7Z79_D      262 ADEAFVTGTLAGLTPVSSVDGRALVP--LGPLTQRLDALY 299
Cdd:cd01558 231 ADEVFLTSTTAEVMPVVEIDGRPIGDgkPGPVTKRLREAY 270
 
Name Accession Description Interval E-value
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 27-299 2.75e-92

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 275.25  E-value: 2.75e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       27 YVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGMR 106
Cdd:cd01558   1 YLNGEYVPREEAKVSVFDRGFLFGDGVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIRELVAKNEGG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      107 DG-AHARlmVTRGVKKTPNQDPRFIigGATVVCVAEH-KVVTPEAKRNGLKLFTStlrcsgPDVFDLRLN--SHSRLNLI 182
Cdd:cd01558  81 EGdVYIQ--VTRGVGPRGHDFPKCV--KPTVVIITQPlPLPPAELLEKGVRVITV------PDIRWLRCDikSLNLLNNV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      183 QALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWTS-SGRYCFNGITRATVVRLAREAGIPVHEGDFTLAEVYA 261
Cdd:cd01558 151 LAKQEAKEAGADEAILLDADGLVTEGSSSNVFIVKNGVLVTPpLDNGILPGITRATVIELAKELGIPVEERPFSLEELYT 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
7Z79_D      262 ADEAFVTGTLAGLTPVSSVDGRALVP--LGPLTQRLDALY 299
Cdd:cd01558 231 ADEVFLTSTTAEVMPVVEIDGRPIGDgkPGPVTKRLREAY 270
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
 25-302 7.70e-92

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 274.83  E-value: 7.70e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        25 LVYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNG 104
Cdd:PRK08320   4 LIYLNGEFVPKEEAKVSVFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIMLEIPLSKEEMTEIVLETLRKNN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       105 MRDgAHARLMVTRGV-------KKTPNqdprfiiggATVVCVAEHKVVTP-EAKRNGLKLFTSTLRCSGPDVFDLRLNSH 176
Cdd:PRK08320  84 LRD-AYIRLVVSRGVgdlgldpRKCPK---------PTVVCIAEPIGLYPgELYEKGLKVITVSTRRNRPDALSPQVKSL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       177 SRLNLIQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWT---SSGryCFNGITRATVVRLAREAGIPVHEGD 253
Cdd:PRK08320 154 NYLNNILAKIEANLAGVDEAIMLNDEGYVAEGTGDNIFIVKNGKLITpptYAG--ALEGITRNAVIEIAKELGIPVREEL 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
7Z79_D       254 FTLAEVYAADEAFVTGTLAGLTPVSSVDGRAL---VPlGPLTQRLDALYRAY 302
Cdd:PRK08320 232 FTLHDLYTADEVFLTGTAAEVIPVVKVDGRVIgdgKP-GPITKKLLEEFREL 282
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 25-309 3.70e-91

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 272.83  E-value: 3.70e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       25 LVYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNG 104
Cdd:COG0115   2 LIWLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVAANG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      105 MRDGaHARLMVTRGVKK----TPNQDPRFIIggatvvCVAEHKVVTPEAKRNGLKLFTSTLRCSGPDVfDLRLNSHSRLN 180
Cdd:COG0115  82 LEDG-YIRPQVTRGVGGrgvfAEEYEPTVII------IASPLPAYPAEAYEKGVRVITSPYRRAAPGG-LGGIKTGNYLN 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      181 LIQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLAEV 259
Cdd:COG0115 154 NVLAKQEAKEAGADEALLLDTDGYVAEGSGSNVFIVKDGVLVTpPLSGGILPGITRDSVIELARELGIPVEERPISLEEL 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
7Z79_D      260 YAADEAFVTGTLAGLTPVSSVDGRAL--VPLGPLTQRLDALYRAYIASANEA 309
Cdd:COG0115 234 YTADEVFLTGTAAEVTPVTEIDGRPIgdGKPGPVTRRLRELYTDIVRGEAED 285
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 27-310 1.17e-61

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 197.97  E-value: 1.17e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D         27 YVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDG----RIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLR 102
Cdd:TIGR01122   1 WMDGEFVDWEDAKVHVLTHALHYGTGVFEGIRAYDTdkgpAIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATRETLRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        103 NGMRDgAHARLMVTRGVKKTpNQDPRfiIGGATVVCVAEH---KVVTPEAKRNGLKLFTSTLRCSGPDVFDLRLNSHSR- 178
Cdd:TIGR01122  81 NNLRS-AYIRPLVFRGDGDL-GLNPR--AGYKPDVIIAAWpwgAYLGEEALEKGIDAKVSSWRRNAPNTIPTAAKAGGNy 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        179 LNLIQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLA 257
Cdd:TIGR01122 157 LNSLLAKSEARRHGYDEAILLDVEGYVAEGSGENIFIVKDGVLFTpPVTSSILPGITRDTVITLAKELGIEVVEQPISRE 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
7Z79_D        258 EVYAADEAFVTGTLAGLTPVSSVDGRALVP--LGPLTQRLDALYRAYIASANEAH 310
Cdd:TIGR01122 237 ELYTADEAFFTGTAAEITPIREVDGRKIGNgrRGPVTKKLQEAFFDLVTGGTEDY 291
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 52-280 3.66e-47

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 158.29  E-value: 3.66e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D         52 GVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGMRDGAhARLMVTRGVKK--TPNQDPRF 129
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGVGR-LRLTVSRGPGGfgLPTSDPTL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        130 IIggatvvCVAEHKVVTPEAKRNGlklfTSTLRCSGPDVFDLRLNSHSRLNLIQALIQAIQAGADEALMLDPNGFVSSCN 209
Cdd:pfam01063  80 AI------FVSALPPPPESKKKGV----ISSLVRRNPPSPLPGAKTLNYLENVLARREAKAQGADDALLLDEDGNVTEGS 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
7Z79_D        210 STNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSSV 280
Cdd:pfam01063 150 TSNVFLVKGGTLYTpPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
 
Name Accession Description Interval E-value
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 27-299 2.75e-92

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 275.25  E-value: 2.75e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       27 YVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGMR 106
Cdd:cd01558   1 YLNGEYVPREEAKVSVFDRGFLFGDGVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIRELVAKNEGG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      107 DG-AHARlmVTRGVKKTPNQDPRFIigGATVVCVAEH-KVVTPEAKRNGLKLFTStlrcsgPDVFDLRLN--SHSRLNLI 182
Cdd:cd01558  81 EGdVYIQ--VTRGVGPRGHDFPKCV--KPTVVIITQPlPLPPAELLEKGVRVITV------PDIRWLRCDikSLNLLNNV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      183 QALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWTS-SGRYCFNGITRATVVRLAREAGIPVHEGDFTLAEVYA 261
Cdd:cd01558 151 LAKQEAKEAGADEAILLDADGLVTEGSSSNVFIVKNGVLVTPpLDNGILPGITRATVIELAKELGIPVEERPFSLEELYT 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
7Z79_D      262 ADEAFVTGTLAGLTPVSSVDGRALVP--LGPLTQRLDALY 299
Cdd:cd01558 231 ADEVFLTSTTAEVMPVVEIDGRPIGDgkPGPVTKRLREAY 270
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
 25-302 7.70e-92

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 274.83  E-value: 7.70e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        25 LVYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNG 104
Cdd:PRK08320   4 LIYLNGEFVPKEEAKVSVFDHGFLYGDGVFEGIRAYNGRVFRLKEHIDRLYDSAKAIMLEIPLSKEEMTEIVLETLRKNN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       105 MRDgAHARLMVTRGV-------KKTPNqdprfiiggATVVCVAEHKVVTP-EAKRNGLKLFTSTLRCSGPDVFDLRLNSH 176
Cdd:PRK08320  84 LRD-AYIRLVVSRGVgdlgldpRKCPK---------PTVVCIAEPIGLYPgELYEKGLKVITVSTRRNRPDALSPQVKSL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       177 SRLNLIQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWT---SSGryCFNGITRATVVRLAREAGIPVHEGD 253
Cdd:PRK08320 154 NYLNNILAKIEANLAGVDEAIMLNDEGYVAEGTGDNIFIVKNGKLITpptYAG--ALEGITRNAVIEIAKELGIPVREEL 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
7Z79_D       254 FTLAEVYAADEAFVTGTLAGLTPVSSVDGRAL---VPlGPLTQRLDALYRAY 302
Cdd:PRK08320 232 FTLHDLYTADEVFLTGTAAEVIPVVKVDGRVIgdgKP-GPITKKLLEEFREL 282
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 25-309 3.70e-91

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 272.83  E-value: 3.70e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       25 LVYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNG 104
Cdd:COG0115   2 LIWLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVAANG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      105 MRDGaHARLMVTRGVKK----TPNQDPRFIIggatvvCVAEHKVVTPEAKRNGLKLFTSTLRCSGPDVfDLRLNSHSRLN 180
Cdd:COG0115  82 LEDG-YIRPQVTRGVGGrgvfAEEYEPTVII------IASPLPAYPAEAYEKGVRVITSPYRRAAPGG-LGGIKTGNYLN 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      181 LIQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLAEV 259
Cdd:COG0115 154 NVLAKQEAKEAGADEALLLDTDGYVAEGSGSNVFIVKDGVLVTpPLSGGILPGITRDSVIELARELGIPVEERPISLEEL 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
7Z79_D      260 YAADEAFVTGTLAGLTPVSSVDGRAL--VPLGPLTQRLDALYRAYIASANEA 309
Cdd:COG0115 234 YTADEVFLTGTAAEVTPVTEIDGRPIgdGKPGPVTRRLRELYTDIVRGEAED 285
PRK12479 PRK12479
branched-chain-amino-acid transaminase;
25-301 5.08e-67

branched-chain-amino-acid transaminase;


Pssm-ID: 183549 [Multi-domain]  Cd Length: 299  Bit Score: 211.74  E-value: 5.08e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        25 LVYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNG 104
Cdd:PRK12479   5 YIYMNGEFVEKEKAVVSVYDHGFLYGDGVFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPLTVDEMEEAVLQTLQKNE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       105 MRDgAHARLMVTRGvKKTPNQDPRFIIGGATVVCVAEHKVVTPEAKRNGLKLFTSTLRCSGPDVFDLRLNSHSRLNLIQA 184
Cdd:PRK12479  85 YAD-AYIRLIVSRG-KGDLGLDPRSCVKPSVIIIAEQLKLFPQEFYDNGLSVVSVASRRNTPDALDPRIKSMNYLNNVLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       185 LIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWTSSGRY-CFNGITRATVVRLAREAGIPVHEGDFTLAEVYAAD 263
Cdd:PRK12479 163 KIEAAQAGVLEALMLNQQGYVCEGSGDNVFVVKDGKVLTPPSYLgALEGITRNSVIELCERLSIPCEERPFTRHDVYVAD 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
7Z79_D       264 EAFVTGTLAGLTPVSSVDGRAL---VPlGPLTQRLDALYRA 301
Cdd:PRK12479 243 EVFLTGTAAELIPVVKVDSREIgdgKP-GSVTKQLTEEFKK 282
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 44-299 3.48e-66

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 208.22  E-value: 3.48e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       44 DAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGMRDGAhARLMVTRGVKK-- 121
Cdd:cd00449   1 DRGLHYGDGVFEGLRAGKGRLFRLDEHLDRLNRSAKRLGLPIPYDREELREALKELVAANNGASLY-IRPLLTRGVGGlg 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      122 -TPNQDPRFiiggaTVVCVAEHKVVTPEAKRNGLKLFTSTLRCSGPDVFDLRLNSHSRLNLIQALIQAIQAGADEALMLD 200
Cdd:cd00449  80 vAPPPSPEP-----TFVVFASPVGAYAKGGEKGVRLITSPDRRRAAPGGTGDAKTGGNLNSVLAKQEAAEAGADEALLLD 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      201 PNGFVSSCNSTNFFAVRNGALWTSSGRYCF-NGITRATVVRLAREAGIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSS 279
Cdd:cd00449 155 DNGYVTEGSASNVFIVKDGELVTPPLDGGIlPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTAAEVTPVTE 234

                       250       260
                ....*....|....*....|..
7Z79_D      280 VDGRALVPL--GPLTQRLDALY 299
Cdd:cd00449 235 IDGRGIGDGkpGPVTRKLRELL 256
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 27-310 1.17e-61

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 197.97  E-value: 1.17e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D         27 YVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDG----RIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLR 102
Cdd:TIGR01122   1 WMDGEFVDWEDAKVHVLTHALHYGTGVFEGIRAYDTdkgpAIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATRETLRK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        103 NGMRDgAHARLMVTRGVKKTpNQDPRfiIGGATVVCVAEH---KVVTPEAKRNGLKLFTSTLRCSGPDVFDLRLNSHSR- 178
Cdd:TIGR01122  81 NNLRS-AYIRPLVFRGDGDL-GLNPR--AGYKPDVIIAAWpwgAYLGEEALEKGIDAKVSSWRRNAPNTIPTAAKAGGNy 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        179 LNLIQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLA 257
Cdd:TIGR01122 157 LNSLLAKSEARRHGYDEAILLDVEGYVAEGSGENIFIVKDGVLFTpPVTSSILPGITRDTVITLAKELGIEVVEQPISRE 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
7Z79_D        258 EVYAADEAFVTGTLAGLTPVSSVDGRALVP--LGPLTQRLDALYRAYIASANEAH 310
Cdd:TIGR01122 237 ELYTADEAFFTGTAAEITPIREVDGRKIGNgrRGPVTKKLQEAFFDLVTGGTEDY 291
PRK06606 PRK06606
branched-chain amino acid transaminase;
21-310 2.01e-51

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 171.87  E-value: 2.01e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        21 NDAVLVYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDG----RIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVV 96
Cdd:PRK06606   4 DRAGYIWFNGELVPWEDAKVHVLTHALHYGTGVFEGIRAYDTpkgpAIFRLREHTKRLFNSAKILRMEIPYSVDELMEAQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        97 VDTFLRNGMRDgAHARLMVTRGVKK----TPNQDPRFIIG----GAtvvcvaehkVVTPEAKRNGLKLFTSTLRCSGPDV 168
Cdd:PRK06606  84 REVVRKNNLKS-AYIRPLVFVGDEGlgvrPHGLPTDVAIAawpwGA---------YLGEEALEKGIRVKVSSWTRHAPNS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       169 FDLR-------LNShsrlnlIQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWT---SSGryCFNGITRATV 238
Cdd:PRK06606 154 IPTRakasgnyLNS------ILAKTEARRNGYDEALLLDVEGYVSEGSGENIFIVRDGVLYTpplTSS--ILEGITRDTV 225

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
7Z79_D       239 VRLAREAGIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSSVDGRALVPL--GPLTQRLDALYRAYIASANEAH 310
Cdd:PRK06606 226 ITLAKDLGIEVIERRITRDELYIADEVFFTGTAAEVTPIREVDGRQIGNGkrGPITEKLQSAYFDIVRGRTEKY 299
D_amino_aminoT TIGR01121
D-amino acid aminotransferase; This enzyme is a homodimer. The pyridoxal phosphate attachment ...
 26-303 1.49e-49

D-amino acid aminotransferase; This enzyme is a homodimer. The pyridoxal phosphate attachment site is the Lys at position 146 of the seed alignment, in the motif Cys-Asp-Ile-Lys-Ser-Leu-Asn. Specificity is broad for various D-amino acids, and differs among members of the family; the family is designated equivalog, but with this caveat attached. [Energy metabolism, Amino acids and amines]


Pssm-ID: 130191  Cd Length: 276  Bit Score: 166.07  E-value: 1.49e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D         26 VYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGM 105
Cdd:TIGR01121   2 VLWNGQLVEREEAKIDIEDRGYQFGDGVYEVIRVYNGKLFTVNEHIDRLYASAAKIRIDIPYTKEELHQLLHELVEKNNL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        106 RDGaHARLMVTRGVKKTPNQDPRFIIGGatVVCVAEHKVVTPEAK-RNGLKLFTSTlrcsgpDVFDLRLNSHSrLNLIQA 184
Cdd:TIGR01121  82 NTG-HVYFQVTRGVAPRNHQFPAGTVKP--VITAYTKEVPRPEENlEKGVKAITVE------DIRWLRCDIKS-LNLLGN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        185 LI---QAIQAGADEALMLDpNGFVSSCNSTNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLAEVY 260
Cdd:TIGR01121 152 VLakqEAHEKGAYEAILHR-GGTVTEGSSSNVYGIKDGVLYThPANNLILNGITRMVILACAEENGIPVKEEPFTKEELL 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
7Z79_D        261 AADEAFVTGTLAGLTPVSSVDGRAL---VPlGPLTQRLDALYRAYI 303
Cdd:TIGR01121 231 NADEVFVSSTTAEITPVIEIDGQQIgdgKP-GPWTRQLQKAFEEKI 275
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 52-280 3.66e-47

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 158.29  E-value: 3.66e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D         52 GVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGMRDGAhARLMVTRGVKK--TPNQDPRF 129
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGVGR-LRLTVSRGPGGfgLPTSDPTL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        130 IIggatvvCVAEHKVVTPEAKRNGlklfTSTLRCSGPDVFDLRLNSHSRLNLIQALIQAIQAGADEALMLDPNGFVSSCN 209
Cdd:pfam01063  80 AI------FVSALPPPPESKKKGV----ISSLVRRNPPSPLPGAKTLNYLENVLARREAKAQGADDALLLDEDGNVTEGS 149

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
7Z79_D        210 STNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSSV 280
Cdd:pfam01063 150 TSNVFLVKGGTLYTpPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
PRK06680 PRK06680
D-amino acid aminotransferase; Reviewed
 26-299 2.69e-43

D-amino acid aminotransferase; Reviewed


Pssm-ID: 180656 [Multi-domain]  Cd Length: 286  Bit Score: 150.08  E-value: 2.69e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        26 VYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGM 105
Cdd:PRK06680   5 AYVNGRYVNHREARVHIEDRGFQFADGIYEVCAVRDGKLVDLDRHLARLFRSLGEIRIAPPMTRAELVEVLRELIRRNRV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       106 RDGAhARLMVTRGVKKT----PNQDPRfiiggATVVCVAEHK---VVTPEAKrNGLKLFTStlrcsgPDVFDLRLNSHSR 178
Cdd:PRK06680  85 REGL-VYLQVTRGVARRdhvfPAADVK-----PSVVVFAKSVdfaRPAAAAE-TGIKVITV------PDNRWKRCDIKSV 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       179 LNLIQALI--QAIQAGADEALMLDpNGFVSSCNSTNFFAV-RNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDF 254
Cdd:PRK06680 152 GLLPNVLAkqAAKEAGAQEAWMVD-DGFVTEGASSNAWIVtKDGKLVTrPADNFILPGITRHTLIDLAKELGLEVEERPF 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
7Z79_D       255 TLAEVYAADEAFVTGTLAGLTPVSSVDGRAL---VPlGPLTQRLDALY 299
Cdd:PRK06680 231 TLQEAYAAREAFITAASSFVFPVVQIDGKQIgngKP-GPIAKRLREAY 277
ADCL_like cd01559
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ...
 44-299 1.37e-41

ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.


Pssm-ID: 238800 [Multi-domain]  Cd Length: 249  Bit Score: 144.76  E-value: 1.37e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       44 DAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMtRAQTKQVVVDTFLRNGMRDGAhARLMVTRGVkktp 123
Cdd:cd01559   1 DRGFAYGDGVFETMRALDGRLFLLDAHLARLERSARRLGIPEPD-LPRLRAALESLLAANDIDEGR-IRLILSRGP---- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      124 nQDPRFIIGGA---TVVCVAehKVVTPEAKRNGLKLFTSTLRCSGPDVFdLRLNSHSRLNLIQALIQAIQAGADEALMLD 200
Cdd:cd01559  75 -GGRGYAPSVCpgpALYVSV--IPLPPAWRQDGVRLITCPVRLGEQPLL-AGLKHLNYLENVLAKREARDRGADEALFLD 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      201 PNGFVSSCNSTNFFAVRNGALWTSSGRYC-FNGITRATVVRLAREAGIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSS 279
Cdd:cd01559 151 TDGRVIEGTASNLFFVKDGELVTPSLDRGgLAGITRQRVIELAAAKGYAVDERPLRLEDLLAADEAFLTNSLLGVAPVTA 230

                       250       260
                ....*....|....*....|
7Z79_D      280 VDGRALVPlGPLTQRLDALY 299
Cdd:cd01559 231 IDDHDGPP-GPLTRALRELL 249
PRK07650 PRK07650
4-amino-4-deoxychorismate lyase; Provisional
 25-303 2.58e-38

4-amino-4-deoxychorismate lyase; Provisional


Pssm-ID: 181067  Cd Length: 283  Bit Score: 137.02  E-value: 2.58e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        25 LVYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNG 104
Cdd:PRK07650   1 LIYVNGQYVEEEEARISPFDHGYLYGLGVFETFRIYNGHPFLLDDHYDRLNDALDTLQIEWTMTKDEVLLILKNLLEKNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       105 MRDgAHARLMVTRGVKktpnqDPRFIIG---GATVVC---------VAEHK--VV------TPEAKRnglklftstlrcs 164
Cdd:PRK07650  81 LEN-AYVRFNVSAGIG-----EIGLQTEmyeEPTVIVymkplappgLPAEKegVVlkqrrnTPEGAF------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       165 gpdvfdlRLNSHSRLNLIQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWTSS---GryCFNGITRATVVRL 241
Cdd:PRK07650 142 -------RLKSHHYLNNILGKREIGNDPNKEGIFLTEEGYVAEGIVSNLFWVKGDIVYTPSletG--ILNGITRAFVIKV 212

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
7Z79_D       242 AREAGIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSSVDGRALV-PLGPLTQRLDALYRAYI 303
Cdd:PRK07650 213 LEELGIEVKEGFYTKEELLSADEVFVTNSIQEIVPLTRIEERDFPgKVGMVTKRLQNLYEMQR 275
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 50-299 6.35e-32

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 119.99  E-value: 6.35e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       50 GDGVWEGV---RLVDGRIVSF--DAHIDRMYEGAKSIALDigmtrAQTKQVVVDtflrngmrdgAHARLmVTRGVKKTPN 124
Cdd:cd01557  12 GQAVFEGLkayRTPDGKIVLFrpDENAERLNRSARRLGLP-----PFSVEEFID----------AIKEL-VKLDADWVPY 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      125 QDP-----R-FIIGGATVVCVAEHkvvtPEAKrngLKLFTS---TLRCSGPDVFDLRLNSHSR---------------LN 180
Cdd:cd01557  76 GGGaslyiRpFIFGTDPQLGVSPA----LEYL---FAVFASpvgAYFKGGEKGVSALVSSFRRaapggpgaakaggnyAA 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D      181 LIQALIQAIQAGADEALMLDP-NGFVSSCNSTNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLAE 258
Cdd:cd01557 149 SLLAQKEAAEKGYDQALWLDGaHGYVAEVGTMNIFFVKDGELITpPLDGSILPGITRDSILELARDLGIKVEERPITRDE 228

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
7Z79_D      259 VYAADEAFVTGTLAGLTPVSSVDGRALVPL----GPLTQRLDALY 299
Cdd:cd01557 229 LYEADEVFATGTAAVVTPVGEIDYRGKEPGegevGPVTKKLYDLL 273
PRK12400 PRK12400
D-amino acid aminotransferase; Reviewed
 35-307 1.24e-30

D-amino acid aminotransferase; Reviewed


Pssm-ID: 171470  Cd Length: 290  Bit Score: 117.04  E-value: 1.24e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        35 RHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGMRDGAHARLM 114
Cdd:PRK12400  18 KQKTYIELEERGLQFGDGVYEVIRLYKGNFHLLDPHITRLYRSMEEIELTLPFSKAELITLLYKLIENNNFHEDGTIYLQ 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       115 VTRGVKKTPNQDPRFIigGATVVCVAEHKvvtpeaKRNGLKLFTSTLRCSGPDVFDLRLNSHSrLNLIQALIQAIQA--- 191
Cdd:PRK12400  98 VSRGVQARTHTFSYDV--PPTIYAYITKK------ERPALWIEYGVRAISEPDTRWLRCDIKS-LNLLPNILAATKAerk 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       192 GADEALMLDpNGFVSSCNSTNFFAVRNGALWTSSGRY-CFNGITRATVVRLAREAGIPVHEGDFTLAEVYAADEAFVTGT 270
Cdd:PRK12400 169 GCKEALFVR-NGTVTEGSHSNFFLIKNGTLYTHPANHlILNGIIRQYVLSLAKTLRIPVQEELFSVRDVYQADECFFTGT 247

                        250       260       270
                 ....*....|....*....|....*....|....*....
7Z79_D       271 LAGLTPVSSVDGRALV--PLGPLTQRLDALYRAYIASAN 307
Cdd:PRK12400 248 TIEILPMTHLDGTAIQdgQVGPITKMLQRSFSQSLLQSN 286
PRK06092 PRK06092
4-amino-4-deoxychorismate lyase; Reviewed
 25-295 2.82e-30

4-amino-4-deoxychorismate lyase; Reviewed


Pssm-ID: 235696  Cd Length: 268  Bit Score: 115.32  E-value: 2.82e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        25 LVYVNGQfvprHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIgmtraqtkqvVVDTFLRNG 104
Cdd:PRK06092   1 MFWINGQ----PQESLSVSDRSTQYGDGCFTTARVRDGQVSLLSRHLQRLQDACERLAIPL----------DDWAQLEQE 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       105 MRDGAHAR------LMVTRGV-----KKTPNQDPRFIIGGATVvcvAEHKVvtpEAKRNGLKLFTSTLRCS-GPdvfdlR 172
Cdd:PRK06092  67 MKQLAAELengvlkVIISRGSggrgySPAGCAAPTRILSVSPY---PAHYS---RWREQGITLALCPTRLGrNP-----L 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       173 LNSHSRLN-LIQALIQAI--QAGADEALMLDPNGFVSSCNSTNFFAVRNGALWTSSGRYC-FNGITRATVVRLAREAGIP 248
Cdd:PRK06092 136 LAGIKHLNrLEQVLIRAEleQTEADEALVLDSEGWVIECCAANLFWRKGGVVYTPDLDQCgVAGVMRQFILELLAQSGYP 215

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
7Z79_D       249 VHEGDFTLAEVYAADEAFVTGTLAGLTPVSSVDGRALvPLGPLTQRL 295
Cdd:PRK06092 216 VVEVDASLEELLQADEVFICNSLMPVWPVRAIGETSY-SSGTLTRYL 261
PRK07544 PRK07544
branched-chain amino acid aminotransferase; Validated
 26-309 3.09e-28

branched-chain amino acid aminotransferase; Validated


Pssm-ID: 181025  Cd Length: 292  Bit Score: 110.45  E-value: 3.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        26 VYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGM 105
Cdd:PRK07544  11 IWMDGELVPWRDAKVHVLTHGLHYASSVFEGERAYGGKIFKLREHSERLRRSAELLDFEIPYSVAEIDAAKKETLAANGL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       106 RDgAHARLMVTRGVK----KTPNQDPRFIIGgatvvCVAEHKVVTPEAKRNGLKLFTSTLRCSGPDVfdlrLNSHSR--- 178
Cdd:PRK07544  91 TD-AYVRPVAWRGSEmmgvSAQQNKIHLAIA-----AWEWPSYFDPEAKMKGIRLDIAKWRRPDPET----APSAAKaag 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       179 LNLIQALI--QAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWTSSGRyCF-NGITRATVVRLAREAGIPVHEGDFT 255
Cdd:PRK07544 161 LYMICTISkhAAEAKGYADALMLDYRGYVAEATGANIFFVKDGVIHTPTPD-CFlDGITRQTVIELAKRRGIEVVERHIM 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
7Z79_D       256 LAEVYAADEAFVTGTLAGLTPVSSVDGRALVPlGPLTQRLDALYRAYIASANEA 309
Cdd:PRK07544 240 PEELAGFSECFLTGTAAEVTPVSEIGEYRFTP-GAITRDLMDDYEALVRPRAAA 292
PRK13356 PRK13356
branched-chain amino acid aminotransferase;
25-307 1.27e-26

branched-chain amino acid aminotransferase;


Pssm-ID: 237362  Cd Length: 286  Bit Score: 106.19  E-value: 1.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        25 LVYVNGQFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDtflrng 104
Cdd:PRK13356   8 WTFFDGEWHEGNVPIMGPADHAAWLGSTVFDGARAFEGVTPDLDLHCARVNRSAEALGLKPTVSAEEIEALARE------ 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       105 mrdgaharlmvtrGVKKTPNQDPRFI-------IGGATVVcvaehkVVTPEAKRNGLKLFTSTLrcSGPDVFDLRLNSHS 177
Cdd:PRK13356  82 -------------GLKRFDPDTALYIrpmywaeDGFASGV------APDPESTRFALCLEEAPM--PEPTGFSLTLSPFR 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       178 RL----------------NLIQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWTSSGRYCF-NGITRATVVR 240
Cdd:PRK13356 141 RPtlemaptdakagclypNNARALREARSRGFDNALVLDMLGNVAETATSNVFMVKDGVVFTPVPNGTFlNGITRQRVIA 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
7Z79_D       241 LAREAGIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSSVDGRALVPlGPLTQRLDALYRAYIASAN 307
Cdd:PRK13356 221 LLREDGVTVVETTLTYEDFLEADEVFSTGNYSKVVPVTRFDDRSLQP-GPVTRRARELYWDWAHGGR 286
PRK07849 PRK07849
aminodeoxychorismate lyase;
22-307 3.45e-22

aminodeoxychorismate lyase;


Pssm-ID: 236114 [Multi-domain]  Cd Length: 292  Bit Score: 94.26  E-value: 3.45e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        22 DAVLVYVNG-----QFVPRHQAVVSVFDAGYVCGDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIAL---DIGMTRAQTk 93
Cdd:PRK07849   5 PPVVVTLDPyggseRVHDPSAPLLHADDLAAVRGDGVFETLLVRDGRPCNLEAHLERLARSAALLDLpepDLDRWRRAV- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        94 QVVVDTFLRNGmrDGAHARLMVTRGVKKTpnqdprfiiGGATV-VCVAEHKVVTPEAKRNGLKLFTSTlRCSGPDVFDL- 171
Cdd:PRK07849  84 ELAIEEWRAPE--DEAALRLVYSRGRESG---------GAPTAwVTVSPVPERVARARREGVSVITLD-RGYPSDAAERa 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       172 --RLNSHSRLNL---IQALIQAIQAGADEALMLDPNGFVSSCNSTNFFAVRNGALWTSSGRY-CFNGITRATVVRLAREA 245
Cdd:PRK07849 152 pwLLAGAKTLSYavnMAALRYAARRGADDVIFTSTDGYVLEGPTSTVVIATDDRLLTPPPWYgILPGTTQAALFEVAREK 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
7Z79_D       246 GIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSSVDGRALvPLGPLTQRLDALYRAYIASAN 307
Cdd:PRK07849 232 GWDCEYRALRPADLFAADGVWLVSSVRLAARVHTLDGRPL-PRDPLADELTELVDAAIVSDR 292
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 183-298 6.31e-13

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 68.25  E-value: 6.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       183 QALIQAIQAGADEALMLDP--NGFVSSCNSTNFFAVRNGALWTSSgrycFN-----GITRATVVRLAREAGIPVHEGDFT 255
Cdd:PRK13357 206 LAQAEAKEKGCDQVLYLDAveHTYIEEVGGMNFFFITKDGTVTPP----LSgsilpGITRDSLLQLAEDLGLTVEERPVS 281

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
7Z79_D       256 LAEVYAA------DEAFVTGTLAGLTPVSSV---DGRALVP---LGPLTQRL-DAL 298
Cdd:PRK13357 282 IDEWQADaasgefTEAFACGTAAVITPIGGIkykDKEFVIGdgeVGPVTQKLyDEL 337
PLN02845 PLN02845
Branched-chain-amino-acid aminotransferase-like protein
 38-298 9.93e-13

Branched-chain-amino-acid aminotransferase-like protein


Pssm-ID: 215454 [Multi-domain]  Cd Length: 336  Bit Score: 67.73  E-value: 9.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        38 AVVSVFDAGYVC-GDGVWEGVRLVDGRIVSFDAHIDRMYEGAKSIALDIGMTRAQTKQVVVDTFLRNGMRDGAhARLMVT 116
Cdd:PLN02845  54 AMVIPLDDHMVHrGHGVFDTATIRDGHLYELDAHLDRFLRSAAKAKIPLPFDRATLRRILLQTVAASGCRNGS-LRYWLS 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       117 RG-----VKKTPNQDPRFIiggatVVCVAEhkvvTPEAKRN-GLKLFTSTLRCSGPDVFDLRLNSHsrlnLIQALIQ--A 188
Cdd:PLN02845 133 AGpggfsLSPSGCSEPAFY-----AVVIED----TYAQDRPeGVKVVTSSVPIKPPQFATVKSVNY----LPNALSQmeA 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       189 IQAGADEALMLDPNGFVSSCNSTNF-FAVRNGALWTSSGRYCFNGITRATVVRLA---REAGI--PVHEGDFTLAEVYAA 262
Cdd:PLN02845 200 EERGAFAGIWLDEEGFVAEGPNMNVaFLTNDGELVLPPFDKILSGCTARRVLELAprlVSPGDlrGVKQRKISVEEAKAA 279

                        250       260       270
                 ....*....|....*....|....*....|....*...
7Z79_D       263 DEAFVTGTLAGLTPVSSVDGRALV--PLGPLTQRLDAL 298
Cdd:PLN02845 280 DEMMLIGSGVPVLPIVSWDGQPIGdgKVGPITLALHDL 317
PRK09266 PRK09266
hypothetical protein; Provisional
 61-304 4.36e-10

hypothetical protein; Provisional


Pssm-ID: 236438  Cd Length: 266  Bit Score: 59.22  E-value: 4.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D        61 DGRIVSFDAHIDRMYEGAKSI---ALDIGMTRAQTKQVVVDT---------------FLRNGMRDGAHARLMVTRGVKKT 122
Cdd:PRK09266  35 DGRVRGLDLHLQRLRRASRELfgaALDDDRVRAQLRAALAAGpadasvrvtvfapdfDFRNPLADVAPDVLVATSPPADG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       123 PnqdprfiiGGATVVCVAEHKVVTPEAKRNGLklftstlrcsgpdvfdlrlnshsrLNLIQALIQAIQAGADEALMLDPN 202
Cdd:PRK09266 115 P--------AGPLRLQSVPYERELPHIKHVGT------------------------FGQLHLRRLAQRAGFDDALFVDPD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       203 GFVSSCNSTNF-FAVRNGALWTSSGryCFNGITRATVVRLAREAGIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSSVD 281
Cdd:PRK09266 163 GRVSEGATWNLgFWDGGAVVWPQAP--ALPGVTMALLQRGLERLGIPQRTRPVTLADLGRFAGAFACNAWRGQRAVSAID 240

                        250       260
                 ....*....|....*....|...
7Z79_D       282 GralVPLGPLTQRLDALYRAYIA 304
Cdd:PRK09266 241 D---VALPDSHALLELLRRAYEA 260
PLN02782 PLN02782
Branched-chain amino acid aminotransferase
 205-280 2.77e-07

Branched-chain amino acid aminotransferase


Pssm-ID: 215418  Cd Length: 403  Bit Score: 51.39  E-value: 2.77e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
7Z79_D       205 VSSCNstnFFAVRNGALWTSSGR-YCFNGITRATVVRLAREAGIPVHEGDFTLAEVYAADEAFVTGTLAGLTPVSSV 280
Cdd:PLN02782 286 VSSCN---IFIVKDNVISTPAIKgTILPGITRKSIIDVARSQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVGSI 359
PLN03117 PLN03117
Branched-chain-amino-acid aminotransferase; Provisional
 181-280 6.36e-07

Branched-chain-amino-acid aminotransferase; Provisional


Pssm-ID: 178664  Cd Length: 355  Bit Score: 50.31  E-value: 6.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       181 LIQALIQAIQAGADEALMLDP--NGFVSSCNSTNFFAVRNGALWT--SSGRyCFNGITRATVVRLAREAGIPVHEGDFTL 256
Cdd:PLN03117 206 VVKSLIEAKSSGFSDVLFLDAatGKNIEELSACNIFILKGNIVSTppTSGT-ILPGVTRKSISELARDIGYQVEERDVSV 284

                         90       100
                 ....*....|....*....|....
7Z79_D       257 AEVYAADEAFVTGTLAGLTPVSSV 280
Cdd:PLN03117 285 DELLEAEEVFCTGTAVVVKAVETV 308
PLN02259 PLN02259
branched-chain-amino-acid aminotransferase 2
 181-280 1.81e-06

branched-chain-amino-acid aminotransferase 2


Pssm-ID: 177901  Cd Length: 388  Bit Score: 48.95  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       181 LIQALIQAIQAGADEALMLDP--NGFVSSCNSTNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLA 257
Cdd:PLN02259 243 VLKALSRAKSRGFSDVLYLDSvkKKYLEEASSCNVFVVKGRTISTpATNGTILEGITRKSVMEIASDQGYQVVEKAVHVD 322

                         90       100
                 ....*....|....*....|...
7Z79_D       258 EVYAADEAFVTGTLAGLTPVSSV 280
Cdd:PLN02259 323 EVMDADEVFCTGTAVVVAPVGTI 345
PLN02883 PLN02883
Branched-chain amino acid aminotransferase
 181-280 2.97e-05

Branched-chain amino acid aminotransferase


Pssm-ID: 178471  Cd Length: 384  Bit Score: 45.09  E-value: 2.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
7Z79_D       181 LIQALIQAIQAGADEALMLDPN--GFVSSCNSTNFFAVRNGALWT-SSGRYCFNGITRATVVRLAREAGIPVHEGDFTLA 257
Cdd:PLN02883 239 VLEVMRRAKSRGFSDVLYLDADtgKNIEEVSAANIFLVKGNIIVTpATSGTILGGITRKSIIEIALDLGYKVEERRVPVE 318

                         90       100
                 ....*....|....*....|...
7Z79_D       258 EVYAADEAFVTGTLAGLTPVSSV 280
Cdd:PLN02883 319 ELKEAEEVFCTGTAAGVASVGSI 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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