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Conserved domains on  [gi|123466615|sp|A0ALM8|]
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RecName: Full=Peptide chain release factor 1; Short=RF-1

Protein Classification

peptide chain release factor 1( domain architecture ID 11415460)

peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA

Gene Ontology:  GO:0016149

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-355 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


:

Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 685.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   1 MYDRLQAVEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLGEKLDDEMREMAKEE 80
Cdd:COG0216    2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  81 FAELQKEKAELEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKE 160
Cdd:COG0216   82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 161 IIAMMNGNDAFSRMKYENGAHRVQRVPETESGGRIHTSTATVAILPEAEEVEIELHDKDIRTDTFASTGAGGQSVNTTMS 240
Cdd:COG0216  162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 241 AVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYDKFEREAREEYDANRKSAVGTGDRSERIRTYNYPQNRVTDHRI 320
Cdd:COG0216  242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 123466615 321 GLTIQKLDQIMEGKLDEIIDALILEDQTSKLEHLN 355
Cdd:COG0216  322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-355 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 685.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   1 MYDRLQAVEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLGEKLDDEMREMAKEE 80
Cdd:COG0216    2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  81 FAELQKEKAELEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKE 160
Cdd:COG0216   82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 161 IIAMMNGNDAFSRMKYENGAHRVQRVPETESGGRIHTSTATVAILPEAEEVEIELHDKDIRTDTFASTGAGGQSVNTTMS 240
Cdd:COG0216  162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 241 AVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYDKFEREAREEYDANRKSAVGTGDRSERIRTYNYPQNRVTDHRI 320
Cdd:COG0216  242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 123466615 321 GLTIQKLDQIMEGKLDEIIDALILEDQTSKLEHLN 355
Cdd:COG0216  322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 1-356 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 658.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   1 MYDRLQAVEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLGEKLDDEMREMAKEE 80
Cdd:PRK00591   4 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  81 FAELQKEKAELEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKE 160
Cdd:PRK00591  84 LKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 161 IIAMMNGNDAFSRMKYENGAHRVQRVPETESGGRIHTSTATVAILPEAEEVEIELHDKDIRTDTFASTGAGGQSVNTTMS 240
Cdd:PRK00591 164 VIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 241 AVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYDKFEREAREEYDANRKSAVGTGDRSERIRTYNYPQNRVTDHRI 320
Cdd:PRK00591 244 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRI 323

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 123466615 321 GLTIQKLDQIMEGKLDEIIDALILEDQTSKLEHLND 356
Cdd:PRK00591 324 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-354 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 549.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615    1 MYDRLQAVEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLgEKLDDEMREMAKEE 80
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEIL-EESDPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   81 FAELQKEKAELEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKE 160
Cdd:TIGR00019  84 LEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  161 IIAMMNGNDAFSRMKYENGAHRVQRVPETESGGRIHTSTATVAILPEAEEVEIELHDKDIRTDTFASTGAGGQSVNTTMS 240
Cdd:TIGR00019 164 VIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  241 AVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYDKFEREAREEYDANRKSAVGTGDRSERIRTYNYPQNRVTDHRI 320
Cdd:TIGR00019 244 AVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRI 323

                         330       340       350
                  ....*....|....*....|....*....|....
gi 123466615  321 GLTIQKLDQIMEGKLDEIIDALILEDQTSKLEHL 354
Cdd:TIGR00019 324 NLTLYKLDEVLEGDLDELIEALIAEDQAQQLAAL 357
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 8-202 4.92e-104

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 303.92  E-value: 4.92e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615    8 VEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLGeklDDEMREMAKEEFAELQKE 87
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   88 KAELEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKEIIAMMNG 167
Cdd:pfam03462  78 LEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 123466615  168 NDAFSRMKYENGAHRVQRVPETESGGRIHTSTATV 202
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
63-177 2.87e-50

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 163.79  E-value: 2.87e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615    63 ELLGEKLDDEMREMAKEEFAELQKEKAELEERLKLLL-VPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESR 141
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELEEELEELLKLLlLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 123466615   142 GWKVEIMDANPTGIGGYKEIIAMMNGNDAFSRMKYE 177
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 1-355 0e+00

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 685.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   1 MYDRLQAVEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLGEKLDDEMREMAKEE 80
Cdd:COG0216    2 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  81 FAELQKEKAELEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKE 160
Cdd:COG0216   82 LEELEARLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 161 IIAMMNGNDAFSRMKYENGAHRVQRVPETESGGRIHTSTATVAILPEAEEVEIELHDKDIRTDTFASTGAGGQSVNTTMS 240
Cdd:COG0216  162 VIFRISGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEEVDVEINPKDLRIDTFRSSGAGGQHVNTTDS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 241 AVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYDKFEREAREEYDANRKSAVGTGDRSERIRTYNYPQNRVTDHRI 320
Cdd:COG0216  242 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQVGSGDRSERIRTYNFPQGRVTDHRI 321

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 123466615 321 GLTIQKLDQIMEGKLDEIIDALILEDQTSKLEHLN 355
Cdd:COG0216  322 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALE 356
prfA PRK00591
peptide chain release factor 1; Validated
 1-356 0e+00

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 658.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   1 MYDRLQAVEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLGEKLDDEMREMAKEE 80
Cdd:PRK00591   4 MLDKLEALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLEEAKEMLEEESDPEMREMAKEE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  81 FAELQKEKAELEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKE 160
Cdd:PRK00591  84 LKELEERLEELEEELKILLLPKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 161 IIAMMNGNDAFSRMKYENGAHRVQRVPETESGGRIHTSTATVAILPEAEEVEIELHDKDIRTDTFASTGAGGQSVNTTMS 240
Cdd:PRK00591 164 VIAEISGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEEVEVEINPKDLRIDTFRSSGAGGQHVNTTDS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 241 AVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYDKFEREAREEYDANRKSAVGTGDRSERIRTYNYPQNRVTDHRI 320
Cdd:PRK00591 244 AVRITHLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQVGSGDRSERIRTYNFPQGRVTDHRI 323

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 123466615 321 GLTIQKLDQIMEGKLDEIIDALILEDQTSKLEHLND 356
Cdd:PRK00591 324 NLTLYKLDEVMEGDLDELIDALIAEDQAEKLAALGE 359
prfA TIGR00019
peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, ...
 1-354 0e+00

peptide chain release factor 1; This model describes peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognize and terminate translation at UAA and UAG stop codons. The mitochondrial release factors are prfA-like, although not included above the trusted cutoff for this model. RF-1 does not have a translational frameshift. [Protein synthesis, Translation factors]


Pssm-ID: 129130 [Multi-domain]  Cd Length: 360  Bit Score: 549.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615    1 MYDRLQAVEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLgEKLDDEMREMAKEE 80
Cdd:TIGR00019   5 LLEKLESLLERYEELEALLSDPEVISDQDKLRKLSKEYSQLEEIVDCYREYQQAQEDIKEAKEIL-EESDPEMREMAKEE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   81 FAELQKEKAELEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKE 160
Cdd:TIGR00019  84 LEELEEKIEELEEQLKVLLLPKDPNDEKNVILEIRAGTGGDEAAIFAGDLFRMYSRYAESKGWKVEILSANETELGGYKE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  161 IIAMMNGNDAFSRMKYENGAHRVQRVPETESGGRIHTSTATVAILPEAEEVEIELHDKDIRTDTFASTGAGGQSVNTTMS 240
Cdd:TIGR00019 164 VIAEIKGDGVYSRLKFESGVHRVQRVPVTESQGRIHTSAATVAVMPELEEVEVDINPADLRIDTFRSSGAGGQHVNTTDS 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  241 AVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYDKFEREAREEYDANRKSAVGTGDRSERIRTYNYPQNRVTDHRI 320
Cdd:TIGR00019 244 AVRITHLPTGIVVECQDERSQHKNKDKAMKVLRARLYEAEQEKQQAAQASTRKSQVGSGDRSERIRTYNFPQNRVTDHRI 323

                         330       340       350
                  ....*....|....*....|....*....|....
gi 123466615  321 GLTIQKLDQIMEGKLDEIIDALILEDQTSKLEHL 354
Cdd:TIGR00019 324 NLTLYKLDEVLEGDLDELIEALIAEDQAQQLAAL 357
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 8-202 4.92e-104

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 303.92  E-value: 4.92e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615    8 VEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLGeklDDEMREMAKEEFAELQKE 87
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLEEAKELLE---DPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   88 KAELEERLKLLLVPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKEIIAMMNG 167
Cdd:pfam03462  78 LEELEEELKLLLLPKDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 123466615  168 NDAFSRMKYENGAHRVQRVPETESGGRIHTSTATV 202
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 5-343 2.47e-86

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 265.10  E-value: 2.47e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615    5 LQAVEDRYDELNELLSDPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLGEKLDDEMREMAKEEFAEL 84
Cdd:TIGR00020  25 PEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAVEEDDEETFNELDAELKAL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615   85 QKEKAELEERLKLllvpKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKEIIAM 164
Cdd:TIGR00020 105 EKKLAELELRTML----SGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDYSEGEEAGIKSVTIL 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  165 MNGNDAFSRMKYENGAHRVQRVPETESGGRIHTSTATVAILPEA-EEVEIELHDKDIRTDTFASTGAGGQSVNTTMSAVR 243
Cdd:TIGR00020 181 IKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVdDDIDIEIKPEDLRIDTYRASGAGGQHVNKTDSAVR 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  244 LTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYDKFEREAREEYDANR--KSAVGTGDrseRIRTYNY-PQNRVTDHRI 320
Cdd:TIGR00020 261 ITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEgeKSEIGWGS---QIRSYVLhPYSMVKDLRT 337

                         330       340
                  ....*....|....*....|...
gi 123466615  321 GLTIQKLDQIMEGKLDEIIDALI 343
Cdd:TIGR00020 338 GYETGNVQAVLDGDIDQFIEAYL 360
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 37-343 1.98e-59

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 194.57  E-value: 1.98e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  37 EQSGITATVETYREYKNVNEQIDETRELLGEKLDDEMREMAKEEFAELQKEkaelEERLKLLLVPKDPNDDKNVILEIRG 116
Cdd:PRK06746  19 EANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQE----MNEYELQLLLSDPYDKNNAILELHP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 117 AAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKEIIAMMNGNDAFSRMKYENGAHRVQRVPETESGGRIH 196
Cdd:PRK06746  95 GAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRH 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 197 TSTATVAILPE-AEEVEIELHDKDIRTDTFASTGAGGQSVNTTMSAVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRAR 275
Cdd:PRK06746 175 TSFVSCEVVPEfNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAK 254

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 123466615 276 VYDKFEREAREEYDANR--KSAVGTGdrsERIRTYNY-PQNRVTDHRIGLTIQKLDQIMEGKLDEIIDALI 343
Cdd:PRK06746 255 LYQKKLEEQQAELDEIRgeQKEIGWG---SQIRSYVFhPYSLVKDHRTNTEVGNVQAVMDGEIDPFIDAYL 322
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 106-341 1.02e-57

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 189.87  E-value: 1.02e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 106 DDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKEIIAMMNGNDAFSRMKYENGAHRVQR 185
Cdd:PRK08787  63 DGANAFVDIQAGAGGTEAQDWAEILLRMYLRWAESRGWKTELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVR 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 186 VPETESGGRIHTSTATVAILPEAEE-VEIELHDKDIRTDTFASTGAGGQSVNTTMSAVRLTHIPTGIVVSMQDERSQLKN 264
Cdd:PRK08787 143 KSPFDSDNRRHTSFTSVFVSPEVDDnIEIDINPADLRTDVYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQN 222

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 123466615 265 KDKAMKVLRARVYDKFEREAREEYDA--NRKSAVGTGdrsERIRTYNYPQNRVTDHRIGLTIQKLDQIMEGKLDEIIDA 341
Cdd:PRK08787 223 RDNAMKMLAAKLYELEVQKRNAEKDAleATKSDIGWG---SQIRNYVLDQSRIKDLRTGIERSDTQKVLDGDLDEFVEA 298
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 209-319 1.65e-56

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 179.54  E-value: 1.65e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  209 EEVEIELHDKDIRTDTFASTGAGGQSVNTTMSAVRLTHIPTGIVVSMQDERSQLKNKDKAMKVLRARVYdKFEREAREEY 288
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLY-ELEEEKEEEK 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 123466615  289 DANRKSAVGTGDRSERIRTYNY-PQNRVTDHR 319
Cdd:pfam00472  80 KRRIKSQVGSGDRSEQIRTYNFkPQSRVKDHR 111
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 19-341 8.25e-56

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 185.01  E-value: 8.25e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  19 LSDPDVVSDPKRLRDLSKEQSGITATVETYReykNVNEQIDETrELLGEKLDDEMREMAKEEFAELQKEKAELEERLKLL 98
Cdd:PRK05589   1 MQEPNFWNDIKEAQEITSEEKYLKDKLDKYN---HLRNRIEDI-EVLCEMMSEEDDEMKKEIISEVKNIKEEIDRFKIET 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  99 LVPKDpNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKEIIAMMNGNDAFSRMKYEN 178
Cdd:PRK05589  77 LLSGE-YDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEK 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 179 GAHRVQRVPETESGGRIHTSTATVAILPE-AEEVEIELHDKDIRTDTFASTGAGGQSVNTTMSAVRLTHIPTGIVVSMQD 257
Cdd:PRK05589 156 GIHRLVRISPFNANGKRQTSFASVEVLPElTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQN 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 258 ERSQLKNKDKAMKVLRARVYDKFEREAREEYD--ANRKSAVGTGDrseRIRTYNY-PQNRVTDHRIGLTIQKLDQIMEGK 334
Cdd:PRK05589 236 ERSQHSNKETAMKMLKSKLVELKERAHKEKIEdlTGELKDMGWGS---QIRSYVFhPYNLVKDHRTGVETSNVDSVMDGD 312


                 ....*..
gi 123466615 335 LDEIIDA 341
Cdd:PRK05589 313 IDNFITQ 319
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 21-341 1.11e-55

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 185.47  E-value: 1.11e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  21 DPDVVSDPKRLRDLSKEQSGITATVETYREYKNVNEQIDETRELLGEKLDDEMREMAKEEFAELQKEkAELEERLKLLLV 100
Cdd:PRK07342   5 DPSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNDNIELIAMGEEEGDKSIVEDAEKTIRDLKDE-IDRRQIDALLSG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 101 PKDPNDdknVILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANPTGIGGYKEIIAMMNGNDAFSRMKYENGA 180
Cdd:PRK07342  84 EADAND---TYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 181 HRVQRVPETESGGRIHTSTATVAILPEAEE-VEIELHDKDIRTDTFASTGAGGQSVNTTMSAVRLTHIPTGIVVSMQDER 259
Cdd:PRK07342 161 HRLVRISPYDSNARRHTSFASIWVYPVIDDnIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQER 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 260 SQLKNKDKAMKVLRARVYDKfEREAREE---YDANRKSAVGTGdrsERIRTYNY-PQNRVTDHRIGLTIQKLDQIMEGKL 335
Cdd:PRK07342 241 SQHKNRAKAWSMLRARLYEE-ELKKREEatnAAAASKTDIGWG---HQIRSYVLqPYQLVKDLRTGVESTNPQDVLDGDL 316


                 ....*.
gi 123466615 336 DEIIDA 341
Cdd:PRK07342 317 NEFMEA 322
PCRF smart00937
This domain is found in peptide chain release factors;
63-177 2.87e-50

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 163.79  E-value: 2.87e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615    63 ELLGEKLDDEMREMAKEEFAELQKEKAELEERLKLLL-VPKDPNDDKNVILEIRGAAGGDEAALFAGDLFRMYSKYAESR 141
Cdd:smart00937   1 ELLEEEEDDEMRELAEEELEELEAELEEELEELLKLLlLPKDPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERK 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 123466615   142 GWKVEIMDANPTGIGGYKEIIAMMNGNDAFSRMKYE 177
Cdd:smart00937  81 GWKVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 212-319 6.52e-28

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 106.37  E-value: 6.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615 212 EIELHDKDIRTDTFASTGAGGQSVNTTMSAVRLTH------------IPTGIVVSMQDERSQLKNKDKAMKVLRARVYDK 279
Cdd:COG1186   20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHdiassslpdsrlTPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 123466615 280 FEREAREEydANRKSAVGTGDRSE--RIRtynypqNRVTDHR 319
Cdd:COG1186  100 ELEPKERR--ATKPTRGSKKRRLWgkQIR------SMVKDLR 133
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 110-311 2.80e-20

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 87.52  E-value: 2.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  110 VILEIRGAAGGDEAALFAGDLFRMYSKYAESRGWKVEIMDANP-TGIGGYKEIIAMMNGN--DAFSRmKYENGAHRVQRV 186
Cdd:TIGR03072   1 ILLQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPgEVPGTLRSALVSLDGEaaAALAD-RWEGTLLWICPS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 123466615  187 PETESGGRihtSTATVAILPEAEEVEIElhDKDIRTDTFASTGAGGQSVNTTMSAVRLTHIPTGIVVSMQDERSQLKNKd 266
Cdd:TIGR03072  80 PYRPHHRR---KNWFIGVQRFSASEEAT--EDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANK- 153

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 123466615  267 KAMKVLRARVYDKFEREAREEYDANRKSAVGTGDRSERIRTYNYP 311
Cdd:TIGR03072 154 RLATLLLAVRLADLQQEQAAALRAERRTAHHQIERGNPVRVFKGE 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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