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Conserved domains on  [gi|158705879|sp|A0JLT2|]
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RecName: Full=Mediator of RNA polymerase II transcription subunit 19; AltName: Full=Lung cancer metastasis-related protein 1; AltName: Full=Mediator complex subunit 19

Protein Classification

mediator of RNA polymerase II transcription subunit 19 family protein( domain architecture ID 10563233)

mediator of RNA polymerase II transcription subunit 19 (Med19) is a component of the mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med19 pfam10278
Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved ...
 63-233 1.34e-79

Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.


:

Pssm-ID: 287279  Cd Length: 178  Bit Score: 237.04  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158705879   63 GPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFN 142
Cdd:pfam10278   1 GPFYLLKELPGYSELTGSTNLLTHYGLEHSYSKFCGKKVKEKLSSFLPHLPGMIDLPGTPENSSLRSLIEKPPIGGKELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158705879  143 PITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDS------DHKKKKKKKEEDPDRKRKKK 216
Cdd:pfam10278  81 PLTSVQLAGFRLHPGPLPEQYRHMHIQPPTKKHKNKHKKHRTQDPYSEETPLDSeglkghEKKHKKKKHEDDKERKKKKK 160

                         170
                  ....*....|....*..
gi 158705879  217 EKKKKKNRHSPDHPGMG 233
Cdd:pfam10278 161 EKKKKKKRHSPEHPGMG 177
 
Name Accession Description Interval E-value
Med19 pfam10278
Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved ...
 63-233 1.34e-79

Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.


Pssm-ID: 287279  Cd Length: 178  Bit Score: 237.04  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158705879   63 GPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFN 142
Cdd:pfam10278   1 GPFYLLKELPGYSELTGSTNLLTHYGLEHSYSKFCGKKVKEKLSSFLPHLPGMIDLPGTPENSSLRSLIEKPPIGGKELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158705879  143 PITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDS------DHKKKKKKKEEDPDRKRKKK 216
Cdd:pfam10278  81 PLTSVQLAGFRLHPGPLPEQYRHMHIQPPTKKHKNKHKKHRTQDPYSEETPLDSeglkghEKKHKKKKHEDDKERKKKKK 160

                         170
                  ....*....|....*..
gi 158705879  217 EKKKKKNRHSPDHPGMG 233
Cdd:pfam10278 161 EKKKKKKRHSPEHPGMG 177
 
Name Accession Description Interval E-value
Med19 pfam10278
Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved ...
 63-233 1.34e-79

Mediator of RNA pol II transcription subunit 19; Med19 represents a family of conserved proteins which are members of the multi-protein co-activator Mediator complex. Mediator is required for activation of RNA polymerase II transcription by DNA binding transactivators.


Pssm-ID: 287279  Cd Length: 178  Bit Score: 237.04  E-value: 1.34e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158705879   63 GPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFN 142
Cdd:pfam10278   1 GPFYLLKELPGYSELTGSTNLLTHYGLEHSYSKFCGKKVKEKLSSFLPHLPGMIDLPGTPENSSLRSLIEKPPIGGKELL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158705879  143 PITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDS------DHKKKKKKKEEDPDRKRKKK 216
Cdd:pfam10278  81 PLTSVQLAGFRLHPGPLPEQYRHMHIQPPTKKHKNKHKKHRTQDPYSEETPLDSeglkghEKKHKKKKHEDDKERKKKKK 160

                         170
                  ....*....|....*..
gi 158705879  217 EKKKKKNRHSPDHPGMG 233
Cdd:pfam10278 161 EKKKKKKRHSPEHPGMG 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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