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Conserved domains on  [gi|254810525|sp|A0ZSF4|]
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RecName: Full=Nacrein-like protein P1

Protein Classification

carbonic anhydrase family protein( domain architecture ID 10085368)

carbonic anhydrase family protein similar to carbonic anhydrase, which catalyzes the reversible hydration of gaseous carbon dioxide to carbonic acid

CATH:  3.10.200.10
Gene Ontology:  GO:0004089|GO:0008270|GO:0006730
PubMed:  10978542|18336305
SCOP:  4002732

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 1-331 3.29e-38

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


:

Pssm-ID: 238200  Cd Length: 227  Bit Score: 135.49  E-value: 3.29e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFKPHMEKLKTEVTNHQNRAPEFEPEDGenlYVKLNNLvDGHYKFHNLHVHNGRTRRKGS 80
Cdd:cd00326    4 QSPINIVTSAVVYDPSLPPLNFDYYPTTSLTLVNNGHTVQVNFDDDGG---TLSGGGL-PGRYKLVQFHFHWGSENSPGS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  81 EHSVNGRFTPMEAHLVFHHDDQTHFEptrtklggAFPGHNDFVVVGVFLEVGddgfgdEPDDEECKRILkghhpdnneng 160
Cdd:cd00326   80 EHTIDGKRYPLELHLVHYNSDYYSSE--------AAKKPGGLAVLGVFFEVG------EKENPFLKKIL----------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 161 ngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkhgcr 240
Cdd:cd00326      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 241 vkkakhlstilecayrnDKVREFKKVGEEEGLDvHLTPEMPLPPLKnRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRR 320
Cdd:cd00326  135 -----------------DALPKIKYKGKETTLP-PFDLSDLLPSSL-RDYYTYEGSLTTPPCSEGVTWIVFKEPITISKE 195

                        330
                 ....*....|.
gi 254810525 321 VLHALRNVEGY 331
Cdd:cd00326  196 QLEAFRSLLDR 206
 
Name Accession Description Interval E-value
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 1-331 3.29e-38

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 135.49  E-value: 3.29e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFKPHMEKLKTEVTNHQNRAPEFEPEDGenlYVKLNNLvDGHYKFHNLHVHNGRTRRKGS 80
Cdd:cd00326    4 QSPINIVTSAVVYDPSLPPLNFDYYPTTSLTLVNNGHTVQVNFDDDGG---TLSGGGL-PGRYKLVQFHFHWGSENSPGS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  81 EHSVNGRFTPMEAHLVFHHDDQTHFEptrtklggAFPGHNDFVVVGVFLEVGddgfgdEPDDEECKRILkghhpdnneng 160
Cdd:cd00326   80 EHTIDGKRYPLELHLVHYNSDYYSSE--------AAKKPGGLAVLGVFFEVG------EKENPFLKKIL----------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 161 ngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkhgcr 240
Cdd:cd00326      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 241 vkkakhlstilecayrnDKVREFKKVGEEEGLDvHLTPEMPLPPLKnRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRR 320
Cdd:cd00326  135 -----------------DALPKIKYKGKETTLP-PFDLSDLLPSSL-RDYYTYEGSLTTPPCSEGVTWIVFKEPITISKE 195

                        330
                 ....*....|.
gi 254810525 321 VLHALRNVEGY 331
Cdd:cd00326  196 QLEAFRSLLDR 206
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 1-328 1.53e-25

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 102.39  E-value: 1.53e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525     1 QSPINIVSYDAKFRQRLPKLKFKPHMEKLKTEVTNHQNRAPEFEPEDgenLYVKLNNLvDGHYKFHNLHVHNGRTRRKGS 80
Cdd:smart01057  25 QSPIDIVTAEAQYDPSLKPLKLSYDQPTAKRILNNGHTVQVNFDDDG---STLSGGPL-PGRYRLKQFHFHWGGSDSEGS 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525    81 EHSVNGRFTPMEAHLVfHHDDQTHFEPTRTKLGGafpghndFVVVGVFLEVGDdgfgdepddeeckrilkghhpdnneng 160
Cdd:smart01057 101 EHTIDGKRFPLELHLV-HYNSKGSFSEAVSKPGG-------LAVVAVFFKVGA--------------------------- 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   161 ngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkhgcr 240
Cdd:smart01057     --------------------------------------------------------------------------------

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   241 vKKAKHLSTILECayrndkvreFKKVgEEEGLDVHLTPEMP--LPPLKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVS 318
Cdd:smart01057 146 -EENPALQAILDH---------LPLI-KYKGQETELTPFDLssLLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPITIS 214

                          330
                   ....*....|
gi 254810525   319 RRVLHALRNV 328
Cdd:smart01057 215 TEQLEKFRTL 224
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
1-328 1.31e-24

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 100.03  E-value: 1.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525    1 QSPINIVSYDAKFRQRLPKLKFKPHMEKL-KTEVTN--HqnrAPEFEPEDGENLYVKLNNLvDGHYKFHNLHVHNGRTRR 77
Cdd:pfam00194  18 QSPINIDTRKVRYDPSLPPLTFQGYDVPPgKNTLTNngH---TVQVSLDDGDPSTISGGPL-ATRYRLVQFHFHWGSTDS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   78 KGSEHSVNGRFTPMEAHLVfhhddqtHFEPTRTKLGGAFPGHNDFVVVGVFLEVGDdgfgdePDDEECKRILkghhpdnn 157
Cdd:pfam00194  94 RGSEHTIDGKRYPAELHIV-------HYNSKYKSFDEAAKHPDGLAVLGVFFEVGD------ENNPYLQPIV-------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  158 engngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkh 237
Cdd:pfam00194     --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  238 gcrvkkaKHLstilecayrnDKVREFKKVGEEEGLDVHLtpempLPPLKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQV 317
Cdd:pfam00194 153 -------SAL----------DNIKYKGKSVLLPPFDLSD-----LLPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPISI 210

                         330
                  ....*....|.
gi 254810525  318 SRRVLHALRNV 328
Cdd:pfam00194 211 SEEQLEAFRTL 221
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-330 1.50e-16

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 77.62  E-value: 1.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSydaKFRQRLPKLKFkpHMEKLKTEVTNHqNRAPEFEPEDGENLyvklnnLVDGH-YKFHNLHVHngrtrrKG 79
Cdd:COG3338   55 QSPIDIRT---AIKADLPPLKF--DYKPTPLEIVNN-GHTIQVNVDPGSTL------TVDGKrYELKQFHFH------TP 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  80 SEHSVNGRFTPMEAHLVfHHDDQTHFeptrtklggafpghndfVVVGVFLEVGDdgfgdepddeeckrilkgHHPdnnen 159
Cdd:COG3338  117 SEHTINGKSYPMEAHLV-HKDADGEL-----------------AVVGVLFEEGA------------------ENP----- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 160 gngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkhgc 239
Cdd:COG3338      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 240 RVKKA-KHLStilecayrndkvrefKKVGEEEGLDVHLTPEMPLPplKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVS 318
Cdd:COG3338  156 ALAKLwANLP---------------LEAGEEVALDATIDLNDLLP--EDRSYYRYSGSLTTPPCSEGVLWIVLKQPITVS 218

                        330
                 ....*....|..
gi 254810525 319 RRVLHALRNVEG 330
Cdd:COG3338  219 AEQIEAFARLYP 230
PLN02179 PLN02179
carbonic anhydrase
 285-312 3.10e-05

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 44.59  E-value: 3.10e-05
                         10        20
                 ....*....|....*....|....*...
gi 254810525 285 LKNRHYYTYEGSLTTPPCTESVLWVVQK 312
Cdd:PLN02179 198 FETNNFYRYIGSLTIPPCTEGVIWTVVK 225
 
Name Accession Description Interval E-value
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 1-331 3.29e-38

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 135.49  E-value: 3.29e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFKPHMEKLKTEVTNHQNRAPEFEPEDGenlYVKLNNLvDGHYKFHNLHVHNGRTRRKGS 80
Cdd:cd00326    4 QSPINIVTSAVVYDPSLPPLNFDYYPTTSLTLVNNGHTVQVNFDDDGG---TLSGGGL-PGRYKLVQFHFHWGSENSPGS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  81 EHSVNGRFTPMEAHLVFHHDDQTHFEptrtklggAFPGHNDFVVVGVFLEVGddgfgdEPDDEECKRILkghhpdnneng 160
Cdd:cd00326   80 EHTIDGKRYPLELHLVHYNSDYYSSE--------AAKKPGGLAVLGVFFEVG------EKENPFLKKIL----------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 161 ngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkhgcr 240
Cdd:cd00326      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 241 vkkakhlstilecayrnDKVREFKKVGEEEGLDvHLTPEMPLPPLKnRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRR 320
Cdd:cd00326  135 -----------------DALPKIKYKGKETTLP-PFDLSDLLPSSL-RDYYTYEGSLTTPPCSEGVTWIVFKEPITISKE 195

                        330
                 ....*....|.
gi 254810525 321 VLHALRNVEGY 331
Cdd:cd00326  196 QLEAFRSLLDR 206
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
 1-329 1.75e-31

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 117.37  E-value: 1.75e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQrLPKLKFKPHMEKlKTEVTNHQNRAPEFEPEDGenlYVKLNNlvdGHYKFHNLHVHNGrtrrkgS 80
Cdd:cd03124   21 QSPIDITTKAVVSDK-LPPLNYNYKPTS-ATLVNNGHTIQVNFEGNGG---TLTIDG---ETYQLLQFHFHSP------S 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  81 EHSVNGRFTPMEAHLVFHHDDqthfeptrtklggafpghNDFVVVGVFLEVGddgfgdePDDEECKRILKGHHpdnneng 160
Cdd:cd03124   87 EHLINGKRYPLEAHLVHKSKD------------------GQLAVVAVLFEEG-------KENPFLKKILDNMP------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 161 ngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkhgcr 240
Cdd:cd03124      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 241 vkkakhlstilecayrndkvrefKKVGEEEGLDVHLTPEMPLPplKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRR 320
Cdd:cd03124  135 -----------------------KKEGTEVNLPAILDPNELLP--ESRSYYRYEGSLTTPPCSEGVRWIVLKQPITISKE 189


                 ....*....
gi 254810525 321 VLHALRNVE 329
Cdd:cd03124  190 QLAKFRAAV 198
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 1-328 1.53e-25

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 102.39  E-value: 1.53e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525     1 QSPINIVSYDAKFRQRLPKLKFKPHMEKLKTEVTNHQNRAPEFEPEDgenLYVKLNNLvDGHYKFHNLHVHNGRTRRKGS 80
Cdd:smart01057  25 QSPIDIVTAEAQYDPSLKPLKLSYDQPTAKRILNNGHTVQVNFDDDG---STLSGGPL-PGRYRLKQFHFHWGGSDSEGS 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525    81 EHSVNGRFTPMEAHLVfHHDDQTHFEPTRTKLGGafpghndFVVVGVFLEVGDdgfgdepddeeckrilkghhpdnneng 160
Cdd:smart01057 101 EHTIDGKRFPLELHLV-HYNSKGSFSEAVSKPGG-------LAVVAVFFKVGA--------------------------- 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   161 ngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkhgcr 240
Cdd:smart01057     --------------------------------------------------------------------------------

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   241 vKKAKHLSTILECayrndkvreFKKVgEEEGLDVHLTPEMP--LPPLKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVS 318
Cdd:smart01057 146 -EENPALQAILDH---------LPLI-KYKGQETELTPFDLssLLPASTRHYYTYNGSLTTPPCSEGVTWIVFKEPITIS 214

                          330
                   ....*....|
gi 254810525   319 RRVLHALRNV 328
Cdd:smart01057 215 TEQLEKFRTL 224
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
1-328 1.31e-24

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 100.03  E-value: 1.31e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525    1 QSPINIVSYDAKFRQRLPKLKFKPHMEKL-KTEVTN--HqnrAPEFEPEDGENLYVKLNNLvDGHYKFHNLHVHNGRTRR 77
Cdd:pfam00194  18 QSPINIDTRKVRYDPSLPPLTFQGYDVPPgKNTLTNngH---TVQVSLDDGDPSTISGGPL-ATRYRLVQFHFHWGSTDS 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   78 KGSEHSVNGRFTPMEAHLVfhhddqtHFEPTRTKLGGAFPGHNDFVVVGVFLEVGDdgfgdePDDEECKRILkghhpdnn 157
Cdd:pfam00194  94 RGSEHTIDGKRYPAELHIV-------HYNSKYKSFDEAAKHPDGLAVLGVFFEVGD------ENNPYLQPIV-------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  158 engngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkh 237
Cdd:pfam00194     --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  238 gcrvkkaKHLstilecayrnDKVREFKKVGEEEGLDVHLtpempLPPLKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQV 317
Cdd:pfam00194 153 -------SAL----------DNIKYKGKSVLLPPFDLSD-----LLPEDLTSYYTYNGSLTTPPCSESVTWIVFKEPISI 210

                         330
                  ....*....|.
gi 254810525  318 SRRVLHALRNV 328
Cdd:pfam00194 211 SEEQLEAFRTL 221
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
1-330 1.50e-16

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 77.62  E-value: 1.50e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSydaKFRQRLPKLKFkpHMEKLKTEVTNHqNRAPEFEPEDGENLyvklnnLVDGH-YKFHNLHVHngrtrrKG 79
Cdd:COG3338   55 QSPIDIRT---AIKADLPPLKF--DYKPTPLEIVNN-GHTIQVNVDPGSTL------TVDGKrYELKQFHFH------TP 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  80 SEHSVNGRFTPMEAHLVfHHDDQTHFeptrtklggafpghndfVVVGVFLEVGDdgfgdepddeeckrilkgHHPdnnen 159
Cdd:COG3338  117 SEHTINGKSYPMEAHLV-HKDADGEL-----------------AVVGVLFEEGA------------------ENP----- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 160 gngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkhgc 239
Cdd:COG3338      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 240 RVKKA-KHLStilecayrndkvrefKKVGEEEGLDVHLTPEMPLPplKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVS 318
Cdd:COG3338  156 ALAKLwANLP---------------LEAGEEVALDATIDLNDLLP--EDRSYYRYSGSLTTPPCSEGVLWIVLKQPITVS 218

                        330
                 ....*....|..
gi 254810525 319 RRVLHALRNVEG 330
Cdd:COG3338  219 AEQIEAFARLYP 230
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
 271-327 5.57e-13

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 67.72  E-value: 5.57e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 254810525 271 GLDV-HLTPEMPlpplknRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHALRN 327
Cdd:cd03123  168 GFNVrELLPEDL------SHYYRYEGSLTTPPCYESVLWTVFRDPVTLSKEQLETLEN 219
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
 1-331 1.29e-12

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 66.52  E-value: 1.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFKPHME-KLKTEVTNHqnrapefepedGENLYVKLNNLV-------DGHYKFHNLHVHN 72
Cdd:cd03117    4 QSPINIVTKKVQYDENLTPFTFTGYDDtTTNWTITNN-----------GHTVQVTLPDGAkisggglPGTYKALQFHFHW 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  73 GRTRRKGSEHSVNGRFTPMEAHLVfhHDDQTHFEPTRTKLGGAfpghnDFVVVGVFLEVGDDgfgdepDDEECKRILkgh 152
Cdd:cd03117   73 GSNGSPGSEHTIDGERYPMELHIV--HIKESYNSLLEALKDSD-----GLAVLGFFIEEGEE------ENTNFDPLI--- 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 153 hpdnnengngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnnge 232
Cdd:cd03117      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 233 nghkhgcrvkkaKHLSTIlecAYRNDKVRefkkvgeeegldvhLTP---EMPLPPLKNRHYYTYEGSLTTPPCTESVLWV 309
Cdd:cd03117  137 ------------SALSNI---PQKGGSTN--------------LTPfslRSLLPSVLLTKYYRYNGSLTTPGCNEAVIWT 187

                        330       340
                 ....*....|....*....|..
gi 254810525 310 VQKCHVQVSRRVLHALRNVEGY 331
Cdd:cd03117  188 VFEEPIPISRAQLDAFSTVLFF 209
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
 1-132 1.76e-12

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 66.31  E-value: 1.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFKPHMEKLKTEVTNHQNRAPEFEpeDGENLYVKLNNLVDGHYKFHNLHVHNGRTRRKGS 80
Cdd:cd03119   28 QSPIDIKTKDAKHDPSLKPLSVSYDPATAKTILNNGHSFNVEFD--DTDDRSVLRGGPLTGSYRLRQFHFHWGSSDDHGS 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 254810525  81 EHSVNGRFTPMEAHLVfhhddqtHFEPTRTKLGGAFPGHNDFVVVGVFLEVG 132
Cdd:cd03119  106 EHTVDGVKYAAELHLV-------HWNSKYGSFGEAAKQPDGLAVVGVFLKVG 150
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
 1-326 3.52e-12

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 65.25  E-value: 3.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKfkphmeklktevTNHQNRAPEFEPEDGENLYVKLNNLVD----------GHYKFHNLHV 70
Cdd:cd03118    4 QSPINIQWRDSVYDPQLAPLR------------VSYDPATCLYIWNNGYSFQVEFDDSTDksgisggpleNHYRLKQFHF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  71 HNGRTRRKGSEHSVNGRFTPMEAHLVfhHDDQTHFEPTRTklggAFPGHNDFVVVGVFLEVGddgfgdepddeeckrilk 150
Cdd:cd03118   72 HWGANNEWGSEHTVDGHTYPAELHLV--HWNSVKYENFEE----AVMEENGLAVIGVFLKLG------------------ 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 151 GHHpdnnengngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnn 230
Cdd:cd03118  128 AHH----------------------------------------------------------------------------- 130

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 231 genghkhgcrvKKAKHLSTILECAYRNDKVREFKKvgeeegldvhLTPEMPLPPlkNRHYYTYEGSLTTPPCTESVLWVV 310
Cdd:cd03118  131 -----------EGLQKLVDALPEVRHKDTVVEFNP----------FDPSCLLPA--CRDYWTYPGSLTTPPLTESVTWII 187

                        330
                 ....*....|....*.
gi 254810525 311 QKCHVQVSRRVLHALR 326
Cdd:cd03118  188 QKQPIEVSPSQLSVFR 203
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
 1-326 4.83e-11

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 62.05  E-value: 4.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFKPHmEKLKTEVTNhQNRAPEFEPEDGENLYVKLNNLVdGHYKFHNLHVHNGRTRRKGS 80
Cdd:cd03121   21 QSPVDIEPSRLLFDPFLTPLRIDTG-RKVSGTFYN-TGRHVSFRPDKDPVVNISGGPLS-YRYRLEEIRLHFGREDEQGS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525  81 EHSVNGRFTPMEAHLVFHHDDQTHfeptrtKLGGAFPGHNDFVVVGVFLEVGDDgfgdepDDEECKRILkghhpdnneng 160
Cdd:cd03121   98 EHTVNGQAFPGEVQLIHYNSELYP------NFSEASKSPNGLVIVSLFVKIGET------SNPELRRLT----------- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 161 ngdngnngyngdngnngdngnngyngdngnngdngnngyngdngnngdngnngengnngengnngengnngenghkhgcr 240
Cdd:cd03121      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 241 vkkakHLSTILECAYRNDKVREfkkvgeeegldVHLTPEMPLPplKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRR 320
Cdd:cd03121  155 -----NRDTITSIRYKGDAYFL-----------QDLSIELLLP--ETDHYITYEGSLTSPGCHETVTWIILNKPIYITKE 216


                 ....*.
gi 254810525 321 VLHALR 326
Cdd:cd03121  217 QMHSLR 222
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
 1-134 3.45e-09

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 56.38  E-value: 3.45e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFK-PHMEKLKTEVTNHqnrAPEFEPEDGENLYVKLNNLVDGHYKFHNLHVHNGRTRRKG 79
Cdd:cd03149    4 QSPIDIVSSEAVYDPKLKPLSLSyDPCTSLSISNNGH---SVMVEFDDSDDKTVITGGPLENPYRLKQFHFHWGAKHGSG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 254810525  80 SEHSVNGRFTPMEAHLVfhhddqtHFEPTRTK-LGGAFPGHNDFVVVGVFLEVGDD 134
Cdd:cd03149   81 SEHTVDGKTFPSELHLV-------HWNAKKYKsFGEAAAAPDGLAVLGVFLETGDE 129
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 251-327 9.92e-09

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 55.18  E-value: 9.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525 251 LECAYRNDKVREFKKV---GEE---EGLDVhltpeMPLPPLKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHA 324
Cdd:cd03125  142 AENTYYSDFISKLAKIkyaGQTttlTSLDV-----RDMLPENLHHYYTYQGSLTTPPCTENVLWFVFDDPVTLSKTQIVK 216


                 ...
gi 254810525 325 LRN 327
Cdd:cd03125  217 LEN 219
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 271-325 2.30e-08

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 54.19  E-value: 2.30e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 254810525 271 GLDV-HLtpempLPPLKNRhYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHAL 325
Cdd:cd03150  166 GLDVsAL-----LPSDLSR-YFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLHTL 215
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
 282-325 7.59e-08

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 52.53  E-value: 7.59e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 254810525 282 LPPLKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHAL 325
Cdd:cd03126  172 LLPKRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLAL 215
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
 278-326 1.17e-07

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 51.76  E-value: 1.17e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 254810525 278 PEMPLPplKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHALR 326
Cdd:cd03149  157 PKCLLP--KSLDYWTYPGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFR 203
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 290-328 4.45e-07

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 50.43  E-value: 4.45e-07
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 254810525 290 YYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHALRNV 328
Cdd:cd03122  184 YYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFREL 222
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 1-135 5.81e-07

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 50.05  E-value: 5.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFKpHMEKL--KTEVTNhqnrapefepeDGENLYVKLNNLV----------DGHYKFHNL 68
Cdd:cd03122   18 QSPIDIVEDTQVQRQGLQPLHFD-GYEELtaSTTLEN-----------TGKTVILRLEGNSsdpfvsggplLGRYKFSEI 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254810525  69 HVHNGRTRRKGSEHSVNGRFTPMEAHLV-FHHDDQTHFEptrtklggAFPGHNDFVVVGVFLEVGDDG 135
Cdd:cd03122   86 TFHWGTCNSDGSEHSIDGHKFPLEMQILhRNTDFFDSFE--------AIKSPGGVLALAYLFELSHED 145
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
 1-137 1.42e-06

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 48.70  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFKPHMEKLK-TEVTNhqnrapefepeDGENLYVKLNN--------LVDGH-YKFHNLHV 70
Cdd:cd03120   16 QSPINLNSREARYDPSLLEVRLSPNYVVCRdCEVIN-----------DGHTIQIILKSksvlsggpLPQGHeFELAEVRF 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254810525  71 HNGRTRRKGSEHSVNGRFTPMEAHLVfhHDDQTHFEPTRTKLGGAfpghNDFVVVGVFLEVGDDGFG 137
Cdd:cd03120   85 HWGRENQRGSEHTVNFKAFPMELHLI--HWNSTLYSSLEEAMGKP----HGIAIIALFVQIGKEHVG 145
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 1-132 4.41e-06

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 47.26  E-value: 4.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFK----PHMEKLKTEVTNH--QNRAPEfepedgeNLYVKLNnlVDGHYKFHNLHVHNGR 74
Cdd:cd03150   17 QSPVDIRPHLVAFCPALRPLELLgfdlPPSPSLRLLNNGHtvQLSLPS-------GLRMALG--PGQEYRALQLHLHWGA 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 254810525  75 TRRKGSEHSVNGRFTPMEAHLVFHHDDQTHFEPTRTKLGGafpghndFVVVGVFLEVG 132
Cdd:cd03150   88 AGRPGSEHTVDGHRFPAEIHVVHLSTAFANLDEALGRPGG-------LAVLAAFLAEG 138
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
 1-132 1.46e-05

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 45.60  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254810525   1 QSPINIVSYDAKFRQRLPKLKFKPHmEKLKTEVTNHQNRAPEFEPEDGENLYVKLnnlVDGHYKFHNLHVHNG-RTRRKG 79
Cdd:cd03126   17 QSPIDIHTDILQYDSSLPPLEFHGY-NVSGTEQFTLTNNGHTVQLSLPPTMHIGG---LPFKYTASQLHLHWGqRGSPEG 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 254810525  80 SEHSVNGRFTPMEAHLVfHHDDQTHfeptrTKLGGAFPGHNDFVVVGVFLEVG 132
Cdd:cd03126   93 SEHTISGKHFAAELHIV-HYNSDKY-----PDISTAMNKSQGLAVLGILIEVG 139
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
 278-328 1.69e-05

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 45.62  E-value: 1.69e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 254810525 278 PEMPLPPLKNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHALRNV 328
Cdd:cd03120  170 PNTLLPDPLLRDYWVYEGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRL 220
PLN02179 PLN02179
carbonic anhydrase
 285-312 3.10e-05

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 44.59  E-value: 3.10e-05
                         10        20
                 ....*....|....*....|....*...
gi 254810525 285 LKNRHYYTYEGSLTTPPCTESVLWVVQK 312
Cdd:PLN02179 198 FETNNFYRYIGSLTIPPCTEGVIWTVVK 225
PLN02202 PLN02202
carbonate dehydratase
 286-327 1.78e-03

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 39.65  E-value: 1.78e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 254810525 286 KNRHYYTYEGSLTTPPCTESVLWVVQKCHVQVSRRVLHALRN 327
Cdd:PLN02202 200 KTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRS 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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