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Conserved domains on  [gi|322518377|sp|A1A5P9|]
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RecName: Full=Melanoma-associated antigen E1; AltName: Full=Alpha-dystrobrevin-associated MAGE Protein; Short=DAMAGE; AltName: Full=MAGE-E1 antigen

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
474-642 1.06e-19

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 88.48  E-value: 1.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  474 LLQFLLLKDQTKYPIKESEMREFIVQEY-RNQFPEILRRAAAHLECIFRFELKELDPEEH-------------------- 532
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEkkttvtsqqrraaakssrsk 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  533 TYILLNKL----------GPVPF-EGLEDIPNGPKMGLLMMILGQIFLNGNQAREADIWEMLWRFGVQRERRL---SVFG 598
Cdd:pfam01454  81 SYILVSTLppeyrvpaiiWPSKApSFVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDTDGTKeipPLNG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 322518377  599 NPKRLLSvEFVWQRYLDYR--PITDCVPVEYEFYWGPRSHVETTKM 642
Cdd:pfam01454 161 NTDDLLK-RLVKQGYLVRTkeGASDDGEEIIEYRVGPRAKVEFGPE 205
MAGE super family cl03220
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
728-888 1.84e-13

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


The actual alignment was detected with superfamily member pfam01454:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 70.38  E-value: 1.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  728 LVQLFLLMDSTKLPIPKKGILYYIGRECSKV-FPDLLNRAARTLNHVYGTELVVLDPRNH-------------------- 786
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENRKRlFKKVFEEAQKILRDVFGMELVELPAKEEkkttvtsqqrraaakssrsk 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  787 SYTLYN-----------RREMEDMEEIMDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGV---QNGRKHVITC 852
Cdd:pfam01454  81 SYILVStlppeyrvpaiIWPSKAPSFVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIdtdGTKEIPPLNG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 322518377  853 -------RYLSQRYIDSLRVPDSDP--VQYDFVWGPRARLETSKM 888
Cdd:pfam01454 161 ntddllkRLVKQGYLVRTKEGASDDgeEIIEYRVGPRAKVEFGPE 205
PHA03247 super family cl33720
large tegument protein UL36; Provisional
26-321 3.39e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   26 RPAAVPGPAVPRDRSDPQilqglgatEGPGTSVLPTPRGGSSTSVPPTASEGSSAPGQLitsEGRNTSQLPTSRKGRGTR 105
Cdd:PHA03247 2588 RPDAPPQSARPRAPVDDR--------GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP---DPHPPPTVPPPERPRDDP 2656
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  106 RPPAVSAGLNAAASITASEGASTPVLPTAPKGSKASEHLTisegaSISEQPQSHEGPNVQPTlGEGSGTSVPPTFSEESG 185
Cdd:PHA03247 2657 APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLT-----SLADPPPPPPTPEPAPH-ALVSATPLPPGPAAARQ 2730
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  186 ISEPLPSGEGLSISVSPTISEGAGINEPSPASKA-PSTSVPPTASNG---LGINLPPTSSEGLSISVLFSASEESDISVP 261
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgPPAPAPPAAPAAgppRRLTRPAVASLSESRESLPSPWDPADPPAA 2810
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  262 ------------------PPSAEGLSTSMPPPSGEVQstwvPPIILEGCSVKVRSTSRKG------------RRTPVRSA 311
Cdd:PHA03247 2811 vlapaaalppaaspagplPPPTSAQPTAPPPPPGPPP----PSLPLGGSVAPGGDVRRRPpsrspaakpaapARPPVRRL 2886
                         330
                  ....*....|
gi 322518377  312 ACESPSPSAE 321
Cdd:PHA03247 2887 ARPAVSRSTE 2896
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
474-642 1.06e-19

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 88.48  E-value: 1.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  474 LLQFLLLKDQTKYPIKESEMREFIVQEY-RNQFPEILRRAAAHLECIFRFELKELDPEEH-------------------- 532
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEkkttvtsqqrraaakssrsk 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  533 TYILLNKL----------GPVPF-EGLEDIPNGPKMGLLMMILGQIFLNGNQAREADIWEMLWRFGVQRERRL---SVFG 598
Cdd:pfam01454  81 SYILVSTLppeyrvpaiiWPSKApSFVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDTDGTKeipPLNG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 322518377  599 NPKRLLSvEFVWQRYLDYR--PITDCVPVEYEFYWGPRSHVETTKM 642
Cdd:pfam01454 161 NTDDLLK-RLVKQGYLVRTkeGASDDGEEIIEYRVGPRAKVEFGPE 205
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
728-888 1.84e-13

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 70.38  E-value: 1.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  728 LVQLFLLMDSTKLPIPKKGILYYIGRECSKV-FPDLLNRAARTLNHVYGTELVVLDPRNH-------------------- 786
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENRKRlFKKVFEEAQKILRDVFGMELVELPAKEEkkttvtsqqrraaakssrsk 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  787 SYTLYN-----------RREMEDMEEIMDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGV---QNGRKHVITC 852
Cdd:pfam01454  81 SYILVStlppeyrvpaiIWPSKAPSFVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIdtdGTKEIPPLNG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 322518377  853 -------RYLSQRYIDSLRVPDSDP--VQYDFVWGPRARLETSKM 888
Cdd:pfam01454 161 ntddllkRLVKQGYLVRTKEGASDDgeEIIEYRVGPRAKVEFGPE 205
PHA03247 PHA03247
large tegument protein UL36; Provisional
26-321 3.39e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   26 RPAAVPGPAVPRDRSDPQilqglgatEGPGTSVLPTPRGGSSTSVPPTASEGSSAPGQLitsEGRNTSQLPTSRKGRGTR 105
Cdd:PHA03247 2588 RPDAPPQSARPRAPVDDR--------GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP---DPHPPPTVPPPERPRDDP 2656
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  106 RPPAVSAGLNAAASITASEGASTPVLPTAPKGSKASEHLTisegaSISEQPQSHEGPNVQPTlGEGSGTSVPPTFSEESG 185
Cdd:PHA03247 2657 APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLT-----SLADPPPPPPTPEPAPH-ALVSATPLPPGPAAARQ 2730
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  186 ISEPLPSGEGLSISVSPTISEGAGINEPSPASKA-PSTSVPPTASNG---LGINLPPTSSEGLSISVLFSASEESDISVP 261
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgPPAPAPPAAPAAgppRRLTRPAVASLSESRESLPSPWDPADPPAA 2810
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  262 ------------------PPSAEGLSTSMPPPSGEVQstwvPPIILEGCSVKVRSTSRKG------------RRTPVRSA 311
Cdd:PHA03247 2811 vlapaaalppaaspagplPPPTSAQPTAPPPPPGPPP----PSLPLGGSVAPGGDVRRRPpsrspaakpaapARPPVRRL 2886
                         330
                  ....*....|
gi 322518377  312 ACESPSPSAE 321
Cdd:PHA03247 2887 ARPAVSRSTE 2896
Nucleoporin_FG2 pfam15967
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ...
47-262 3.16e-04

Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif.


Pssm-ID: 435043 [Multi-domain]  Cd Length: 586  Bit Score: 44.66  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   47 GLGATEGPGTSVlptprgGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGT-RRPPAVSAGLNAAASITASEG 125
Cdd:pfam15967  11 GSTATAGGGFSF------GAAAASNPGSTGGFSFGTLGAAPAATATTTTATLGLGGGLfGQKPATGFTFGTPASSTAATG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  126 AS-----TPVLPTA-----------PKGSKASEHLTISEGAS---------ISEQPQSHEGPNvqpTLGEGSGTSVPPTF 180
Cdd:pfam15967  85 PTgltlgTPAATTAastgfslgfnkPAASATPFSLPASSTSGgglslgsvlTSTAAQQGATGF---TLNLGGTPATTTAV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  181 SEESGISEPLPS-GEGLSISVSPT-ISEGAGINEPSPASKAPSTSvpPTASNGLGINLPPTSSEGLSISVLFSASEES-- 256
Cdd:pfam15967 162 STGLSLGSTLTSlGGSLFQNTNSTgLGQTTLGLTLLATSTAPVSA--PAASEGLGGLDFSTSSEKKSDKASGTRPEDSka 239

                  ....*...
gi 322518377  257 --DISVPP 262
Cdd:pfam15967 240 lkDENLPP 247
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
25-237 4.08e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 40.89  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  25 GRPAAVPGPAVPRDRSDPQILQGLGATEGPGTSVLPTPRGGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGT 104
Cdd:COG3469    4 VSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATAT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377 105 R-RPPAVSAGLNAAASITASEGASTPVLPTAPKGSKASehltiSEGASISEQPQSHEGPNVQPTLGEGS--GTSVPPTFS 181
Cdd:COG3469   84 AaAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGS-----VTSTTSSTAGSTTTSGASATSSAGSTttTTTVSGTET 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 322518377 182 EESGISEPLPSGEGLSISVSPTISEGAGINEPSPASkAPSTSVPPTASNGLGINLP 237
Cdd:COG3469  159 ATGGTTTTSTTTTTTSASTTPSATTTATATTASGAT-TPSATTTATTTGPPTPGLP 213
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
46-208 4.56e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 40.76  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   46 QGLGATEGPGTSvlpTPRGGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGTRRPPAVSAGLnaaaSITASEG 125
Cdd:NF033849  409 ASQGGSEGWGSG---DSVQSVSQSYGSSSSTGTSSGHSDSSSHSTSSGQADSVSQGTSWSEGTGTSQGQ----SVGTSES 481
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  126 ASTPVLPTAPKGSKASEHLTISEGASISEqpqshegpnvqpTLGEGSGTSVpptfSEESGISeplpSGEGLSISVSPTIS 205
Cdd:NF033849  482 WSTSQSETDSVGDSTGTSESVSQGDGRST------------GRSESQGTSL----GTSGGRT----SGAGGSMGLGPSIS 541

                  ...
gi 322518377  206 EGA 208
Cdd:NF033849  542 LGK 544
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
474-642 1.06e-19

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 88.48  E-value: 1.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  474 LLQFLLLKDQTKYPIKESEMREFIVQEY-RNQFPEILRRAAAHLECIFRFELKELDPEEH-------------------- 532
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEkkttvtsqqrraaakssrsk 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  533 TYILLNKL----------GPVPF-EGLEDIPNGPKMGLLMMILGQIFLNGNQAREADIWEMLWRFGVQRERRL---SVFG 598
Cdd:pfam01454  81 SYILVSTLppeyrvpaiiWPSKApSFVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDTDGTKeipPLNG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 322518377  599 NPKRLLSvEFVWQRYLDYR--PITDCVPVEYEFYWGPRSHVETTKM 642
Cdd:pfam01454 161 NTDDLLK-RLVKQGYLVRTkeGASDDGEEIIEYRVGPRAKVEFGPE 205
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
728-888 1.84e-13

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 70.38  E-value: 1.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  728 LVQLFLLMDSTKLPIPKKGILYYIGRECSKV-FPDLLNRAARTLNHVYGTELVVLDPRNH-------------------- 786
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENRKRlFKKVFEEAQKILRDVFGMELVELPAKEEkkttvtsqqrraaakssrsk 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  787 SYTLYN-----------RREMEDMEEIMDSPNRPGNNFLMQVLSFIFIMGNHARESAVWAFLRGLGV---QNGRKHVITC 852
Cdd:pfam01454  81 SYILVStlppeyrvpaiIWPSKAPSFVLDQDEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIdtdGTKEIPPLNG 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 322518377  853 -------RYLSQRYIDSLRVPDSDP--VQYDFVWGPRARLETSKM 888
Cdd:pfam01454 161 ntddllkRLVKQGYLVRTKEGASDDgeEIIEYRVGPRAKVEFGPE 205
PHA03247 PHA03247
large tegument protein UL36; Provisional
26-321 3.39e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   26 RPAAVPGPAVPRDRSDPQilqglgatEGPGTSVLPTPRGGSSTSVPPTASEGSSAPGQLitsEGRNTSQLPTSRKGRGTR 105
Cdd:PHA03247 2588 RPDAPPQSARPRAPVDDR--------GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP---DPHPPPTVPPPERPRDDP 2656
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  106 RPPAVSAGLNAAASITASEGASTPVLPTAPKGSKASEHLTisegaSISEQPQSHEGPNVQPTlGEGSGTSVPPTFSEESG 185
Cdd:PHA03247 2657 APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLT-----SLADPPPPPPTPEPAPH-ALVSATPLPPGPAAARQ 2730
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  186 ISEPLPSGEGLSISVSPTISEGAGINEPSPASKA-PSTSVPPTASNG---LGINLPPTSSEGLSISVLFSASEESDISVP 261
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgPPAPAPPAAPAAgppRRLTRPAVASLSESRESLPSPWDPADPPAA 2810
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  262 ------------------PPSAEGLSTSMPPPSGEVQstwvPPIILEGCSVKVRSTSRKG------------RRTPVRSA 311
Cdd:PHA03247 2811 vlapaaalppaaspagplPPPTSAQPTAPPPPPGPPP----PSLPLGGSVAPGGDVRRRPpsrspaakpaapARPPVRRL 2886
                         330
                  ....*....|
gi 322518377  312 ACESPSPSAE 321
Cdd:PHA03247 2887 ARPAVSRSTE 2896
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
27-358 1.07e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.87  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   27 PAAVPGPAVPRDRSDPQILQGLGATEGPGTSVLPtprgGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGTRR 106
Cdd:PHA03307  122 PPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAA----GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPST 197
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  107 PPAVSAGLNAAASITASEGASTPVlPTAPKGSKASEHLTiSEGASISEQPQSHEGP-NVQPTLGEGSGTSVPPTFSEESG 185
Cdd:PHA03307  198 PPAAASPRPPRRSSPISASASSPA-PAPGRSAADDAGAS-SSDSSSSESSGCGWGPeNECPLPRPAPITLPTRIWEASGW 275
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  186 ISEPlpsgeglsiSVSPTISEGAGINEPSPASKAPSTSVPPTASnglginlPPTSSEGLSISvlfSASEESDISVPPPSA 265
Cdd:PHA03307  276 NGPS---------SRPGPASSSSSPRERSPSPSPSSPGSGPAPS-------SPRASSSSSSS---RESSSSSTSSSSESS 336
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  266 EGLSTSMPPPSGEVQSTWVPPIILEGCSVKVRSTSRKGRRTPVRSAA-CESPSPSAECLSTSLSSISAEGFCSSLAPCAE 344
Cdd:PHA03307  337 RGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGrPTRRRARAAVAGRARRRDATGRFPAGRPRPSP 416
                         330
                  ....*....|....*
gi 322518377  345 -GSDTCELLPCGEGP 358
Cdd:PHA03307  417 lDAGAASGAFYARYP 431
PHA03247 PHA03247
large tegument protein UL36; Provisional
22-286 9.08e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 9.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   22 SGKGRPAAVPGPAV-PRDRSDPQI---LQGLGATEGPGTSVLPTPRGGSS-TSVPP-TASEGSSAPGQLITSEGRNTSQL 95
Cdd:PHA03247 2668 RRLGRAAQASSPPQrPRRRAARPTvgsLTSLADPPPPPPTPEPAPHALVSaTPLPPgPAAARQASPALPAAPAPPAVPAG 2747
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   96 PTSRKGRGTRRPPAVSAGLNAAASITASEGASTPVLPTAPKGSKASEHLTISEGASISEQPQSHEGPN-VQPTLGEGSGT 174
Cdd:PHA03247 2748 PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAaALPPAASPAGP 2827
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  175 SVPPTFSEE---SGISEPLPSGEGLSISVSPtiseGAGINEPSPASKAPSTSVPPTASNGLGINLPPTSSEGLSIsvlfs 251
Cdd:PHA03247 2828 LPPPTSAQPtapPPPPGPPPPSLPLGGSVAP----GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF----- 2898
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 322518377  252 aSEESDISVPPPSAEGLSTSMPPPSGEVQSTWVPP 286
Cdd:PHA03247 2899 -ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
25-334 1.43e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   25 GRPAAVPGPAVPRDRSDPQILQGLGATEGPGTSVLPTPRGGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGT 104
Cdd:PHA03307   38 GSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPP 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  105 RRPPAVSAGLNAAASITASEGASTPVLPTAPKGSKASEHLtiSEGASISEQPQSHEGPNVQPTLGEGSGTSVPPtfSEES 184
Cdd:PHA03307  118 PPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGA--SPAAVASDAASSRQAALPLSSPEETARAPSSP--PAEP 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  185 GISEPLPSGEGLSISVSPTISEGAGINEPSP----ASKAPSTSVPPTASNGLGINLPPTSSEGLSISVLFSASEESDISV 260
Cdd:PHA03307  194 PPSTPPAAASPRPPRRSSPISASASSPAPAPgrsaADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEAS 273
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 322518377  261 PPPSAEGLSTSMPPPSGEVQSTWVPPIILEGCSVKVRSTSRKGRRTPVRSAACESPSPSAECLSTSLSSISAEG 334
Cdd:PHA03307  274 GWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSP 347
Nucleoporin_FG2 pfam15967
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ...
47-262 3.16e-04

Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif.


Pssm-ID: 435043 [Multi-domain]  Cd Length: 586  Bit Score: 44.66  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   47 GLGATEGPGTSVlptprgGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGT-RRPPAVSAGLNAAASITASEG 125
Cdd:pfam15967  11 GSTATAGGGFSF------GAAAASNPGSTGGFSFGTLGAAPAATATTTTATLGLGGGLfGQKPATGFTFGTPASSTAATG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  126 AS-----TPVLPTA-----------PKGSKASEHLTISEGAS---------ISEQPQSHEGPNvqpTLGEGSGTSVPPTF 180
Cdd:pfam15967  85 PTgltlgTPAATTAastgfslgfnkPAASATPFSLPASSTSGgglslgsvlTSTAAQQGATGF---TLNLGGTPATTTAV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  181 SEESGISEPLPS-GEGLSISVSPT-ISEGAGINEPSPASKAPSTSvpPTASNGLGINLPPTSSEGLSISVLFSASEES-- 256
Cdd:pfam15967 162 STGLSLGSTLTSlGGSLFQNTNSTgLGQTTLGLTLLATSTAPVSA--PAASEGLGGLDFSTSSEKKSDKASGTRPEDSka 239

                  ....*...
gi 322518377  257 --DISVPP 262
Cdd:pfam15967 240 lkDENLPP 247
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
22-321 7.69e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 7.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  22 SGKGRPAAVPGPAVPRDRSDPqilqGLGATEGPGTSVLPtPRGGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKG 101
Cdd:PRK07003 363 TGGGAPGGGVPARVAGAVPAP----GARAAAAVGASAVP-AVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATAD 437
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377 102 RGTR---RPPAVSAGLNAAASITASEGASTPVLPTAPKGSKAsehltisegasiseqPQSHEGPnvqPTLGEGSGTSVPP 178
Cdd:PRK07003 438 RGDDaadGDAPVPAKANARASADSRCDERDAQPPADSGSASA---------------PASDAPP---DAAFEPAPRAAAP 499
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377 179 TFSEESGISEPLPSgeglsiSVSPTISEGAGINEPSP--ASKAPSTSVPPTASNGLGINLPPTSSEGLSISVlfSASEES 256
Cdd:PRK07003 500 SAATPAAVPDARAP------AAASREDAPAAAAPPAPeaRPPTPAAAAPAARAGGAAAALDVLRNAGMRVSS--DRGARA 571
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 322518377 257 DISVPPPSAEGLSTSMPPPSGEVQstwVPpiilegcsvkvrsTSRKGRRTPVRSAACESPSPSAE 321
Cdd:PRK07003 572 AAAAKPAAAPAAAPKPAAPRVAVQ---VP-------------TPRARAATGDAPPNGAARAEQAA 620
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
31-287 1.41e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   31 PGPAVPRD-RSDPQILQGLGATEGpgtsvLPTPRGGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGTRRPPA 109
Cdd:pfam03154 274 QMPPMPHSlQTGPSHMQHPVPPQP-----FPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPA 348
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  110 VSaglnAAASITASEGASTPVLPTaPKGSKASEHLT----ISEGASISEQP--------QSHEGPNVQPtlgegsgtsvP 177
Cdd:pfam03154 349 PL----SMPHIKPPPTTPIPQLPN-PQSHKHPPHLSgpspFQMNSNLPPPPalkplsslSTHHPPSAHP----------P 413
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  178 PTFSEESGISEPLPSGEGLSISVSPTISEGAGiNEPSPASKAPSTSVPPTASNGLginLPPTSSEGLSISVLFSASEESD 257
Cdd:pfam03154 414 PLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAA-SHPPTSGLHQVPSQSPFPQHPF---VPGGPPPITPPSGPPTSTSSAM 489
                         250       260       270
                  ....*....|....*....|....*....|
gi 322518377  258 ISVPPPSAEGLSTSMPPPSgeVQSTWVPPI 287
Cdd:pfam03154 490 PGIQPPSSASVSSSGPVPA--AVSCPLPPV 517
PHA03247 PHA03247
large tegument protein UL36; Provisional
27-285 1.65e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   27 PAAVPGPAVPRDRSDPQIlQGLGATEGPGTSVLPTPRGGSSTSVPPTAS-EGSSAPGqlitsegrntsqlptsrkGRGTR 105
Cdd:PHA03247 2804 PADPPAAVLAPAAALPPA-ASPAGPLPPPTSAQPTAPPPPPGPPPPSLPlGGSVAPG------------------GDVRR 2864
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  106 RPPAVSAglnaaasitasegASTPVLPTAPKGSKASEhltisegASISEQPQSHEGPNVQPTLGEGSGTSVPPTFSEESG 185
Cdd:PHA03247 2865 RPPSRSP-------------AAKPAAPARPPVRRLAR-------PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  186 ISE---PLPSGEGLSISVSPTISEGAGINEPSPASKAPSTSVPPTASNGLGINLPPTSSEGLSISvlfSASEESDISVPP 262
Cdd:PHA03247 2925 PPPqpqPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP---ASSTPPLTGHSL 3001
                         250       260       270
                  ....*....|....*....|....*....|
gi 322518377  263 PSAEGLSTSM-------PPPSGEVQSTWVP 285
Cdd:PHA03247 3002 SRVSSWASSLalheetdPPPVSLKQTLWPP 3031
PHA03249 PHA03249
DNA packaging tegument protein UL25; Provisional
36-176 2.20e-03

DNA packaging tegument protein UL25; Provisional


Pssm-ID: 223023  Cd Length: 653  Bit Score: 41.92  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  36 PRDRSDPQILQGLGATEGPGTSVLPTPRGGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGTRRPPAVSAGLN 115
Cdd:PHA03249  33 PRPRAPTEDLDRMEAGLSSYSSSSDNKSSFEVVSETDSGSEAEAERGRRAGMGGRNKATKPSRRNKTTQCRPTSLALATA 112
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 322518377 116 AAASITASEG-----ASTPVLPTAPKGSKASEHLTISEGASIS--EQPQSHEGPNVQPTLGEGSGTSV 176
Cdd:PHA03249 113 ATMPATPSSGkspkvSSPPSIPSLSEEDEGAERNSGGDDSSHTdnESTQSQPEADDEPDLAEGHEFSF 180
PHA03377 PHA03377
EBNA-3C; Provisional
22-285 2.82e-03

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 41.58  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   22 SGKGRPAAVPGPAVPRDRSDPQILQGLGATEGPGTSVLPTPRGGSSTSVPPTASEGSSAPGQlitsegrntSQLPTSrkG 101
Cdd:PHA03377  543 SGRRQKRATPPKVSPSDRGPPKASPPVMAPPSTGPRVMATPSTGPRDMAPPSTGPRQQAKCK---------DGPPAS--G 611
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  102 RGTRRPPAVSAGLNAAASITASEGASTPVLPTAPKGSKASEHLTISEGASISEQPQSHEGPNVQPTlgEGSGTSVPPTFS 181
Cdd:PHA03377  612 PHEKQPPSSAPRDMAPSVVRMFLRERLLEQSTGPKPKSFWEMRAGRDGSGIQQEPSSRRQPATQST--PPRPSWLPSVFV 689
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  182 EES-GISEPLPSGEGLSISVSPTisegaginEPSPASKAPSTSVPPTAsngLGINLPPTSSEGLSISVLFSASEESDISV 260
Cdd:PHA03377  690 LPSvDAGRAQPSEESHLSSMSPT--------QPISHEEQPRYEDPDDP---LDLSLHPDQAPPPSHQAPYSGHEEPQAQQ 758
                         250       260       270
                  ....*....|....*....|....*....|....
gi 322518377  261 ---------PPPSAEGLSTSMPPPSGeVQSTWVP 285
Cdd:PHA03377  759 apypgywepRPPQAPYLGYQEPQAQG-VQVSSYP 791
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
27-288 3.21e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  27 PAAVPGPAVPRDRSDPQILQGLGATEGPGTSVLPTPRGGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGTRR 106
Cdd:PRK07003 426 PPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPA 505
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377 107 PPAVSAGLNAAASITASEGASTPVLPTAPKGSKASEHLTISEGASISEQPQSHEGPNVQPTLGEGSGTSVPPTFSEEsgi 186
Cdd:PRK07003 506 AVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPA--- 582
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377 187 SEPLPSGEGLSISV-SPTISEGAGINEPSPASKAP-----STSVPPTAsnglgiNLPPTSSEGLSISVLFSASEES---- 256
Cdd:PRK07003 583 AAPKPAAPRVAVQVpTPRARAATGDAPPNGAARAEqaaesRGAPPPWE------DIPPDDYVPLSADEGFGGPDDGfvpv 656
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 322518377 257 ------DISVPPPSAEglstsmpPPSGEVQSTWVPPII 288
Cdd:PRK07003 657 fdsgpdDVRVAPKPAD-------APAPPVDTRPLPPAI 687
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
25-237 4.08e-03

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 40.89  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  25 GRPAAVPGPAVPRDRSDPQILQGLGATEGPGTSVLPTPRGGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGT 104
Cdd:COG3469    4 VSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATAT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377 105 R-RPPAVSAGLNAAASITASEGASTPVLPTAPKGSKASehltiSEGASISEQPQSHEGPNVQPTLGEGS--GTSVPPTFS 181
Cdd:COG3469   84 AaAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGS-----VTSTTSSTAGSTTTSGASATSSAGSTttTTTVSGTET 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 322518377 182 EESGISEPLPSGEGLSISVSPTISEGAGINEPSPASkAPSTSVPPTASNGLGINLP 237
Cdd:COG3469  159 ATGGTTTTSTTTTTTSASTTPSATTTATATTASGAT-TPSATTTATTTGPPTPGLP 213
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
46-208 4.56e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 40.76  E-value: 4.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377   46 QGLGATEGPGTSvlpTPRGGSSTSVPPTASEGSSAPGQLITSEGRNTSQLPTSRKGRGTRRPPAVSAGLnaaaSITASEG 125
Cdd:NF033849  409 ASQGGSEGWGSG---DSVQSVSQSYGSSSSTGTSSGHSDSSSHSTSSGQADSVSQGTSWSEGTGTSQGQ----SVGTSES 481
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  126 ASTPVLPTAPKGSKASEHLTISEGASISEqpqshegpnvqpTLGEGSGTSVpptfSEESGISeplpSGEGLSISVSPTIS 205
Cdd:NF033849  482 WSTSQSETDSVGDSTGTSESVSQGDGRST------------GRSESQGTSL----GTSGGRT----SGAGGSMGLGPSIS 541

                  ...
gi 322518377  206 EGA 208
Cdd:NF033849  542 LGK 544
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
34-209 6.74e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 39.96  E-value: 6.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377  34 AVPRDRSDPQILQGLG-ATEGPG----TSVLPTPRGGSSTSVPPtASEGSSAPGQLITSEGRNTSQLPTSRKGRGTRRPP 108
Cdd:PRK13108 274 LAPKGREAPGALRGSEyVVDEALerepAELAAAAVASAASAVGP-VGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQV 352
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 322518377 109 AVSAGLNAAASITASEGASTPVLPTAPKGSKASEHLTISEGAsiSEQPQSHEgpNVQPTLGEGSGTSVPPTFSEESGISE 188
Cdd:PRK13108 353 ADRDGESTPAVEETSEADIEREQPGDLAGQAPAAHQVDAEAA--SAAPEEPA--ALASEAHDETEPEVPEKAAPIPDPAK 428
                        170       180
                 ....*....|....*....|..
gi 322518377 189 P-LPSGEGlsISVSPTISEGAG 209
Cdd:PRK13108 429 PdELAVAG--PGDDPAEPDGIR 448
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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