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Conserved domains on  [gi|166226678|sp|A2BMC7|]
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RecName: Full=Ribonuclease P protein component 1; Short=RNase P component 1; AltName: Full=Rpp29

Protein Classification

ribonuclease P protein component 1( domain architecture ID 10003987)

ribonuclease P protein component 1 (Rpp29) is part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POP4 COG1588
RNase P/RNase MRP subunit p29 [Translation, ribosomal structure and biogenesis];
2-96 3.69e-32

RNase P/RNase MRP subunit p29 [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 441196  Cd Length: 94  Bit Score: 108.38  E-value: 3.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166226678   2 KRTAWNIVFHSLIGLRARVLATSDPGLRGLEGVVVEETRHSLVVETRDGrRVRVLKANSIFLFQLPGGSWVVVRGEEIAG 81
Cdd:COG1588    1 MITPENILRHELIGLEVEVVESTNPSLVGISGRVVDETKNTLVIETEDG-VKRVPKSGATFEFTLPDGESVTVDGSLLLG 79

                         90
                 ....*....|....*
gi 166226678  82 SLAERVKRLGRLKGV 96
Cdd:COG1588   80 RPEERLKKLIKKKWR 94
 
Name Accession Description Interval E-value
POP4 COG1588
RNase P/RNase MRP subunit p29 [Translation, ribosomal structure and biogenesis];
2-96 3.69e-32

RNase P/RNase MRP subunit p29 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441196  Cd Length: 94  Bit Score: 108.38  E-value: 3.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166226678   2 KRTAWNIVFHSLIGLRARVLATSDPGLRGLEGVVVEETRHSLVVETRDGrRVRVLKANSIFLFQLPGGSWVVVRGEEIAG 81
Cdd:COG1588    1 MITPENILRHELIGLEVEVVESTNPSLVGISGRVVDETKNTLVIETEDG-VKRVPKSGATFEFTLPDGESVTVDGSLLLG 79

                         90
                 ....*....|....*
gi 166226678  82 SLAERVKRLGRLKGV 96
Cdd:COG1588   80 RPEERLKKLIKKKWR 94
RNase_P-MRP_p29 pfam01868
Ribonuclease P/MRP, subunit p29; This family consists of several archaeal and eukaryotic ...
 6-89 9.30e-26

Ribonuclease P/MRP, subunit p29; This family consists of several archaeal and eukaryotic proteins. The archaeal proteins are found to be expressed within ribosomal operons and several of the sequences are described as ribonuclease P protein subunit p29 proteins. The structure of the RNase P subunit, Rpp29, from Methanobacterium thermoautotrophicum has been determined. Mth Rpp29 is a member of the oligonucleotide/oligosaccharide binding fold family. It contains a structured beta-barrel core and unstructured N- and C-terminal extensions bearing several highly conserved amino acid residues that could be involved in RNA contacts in the protein-RNA complex. Rpp29 catalyzes the endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. It interacts with the Rpp25 and Pop5 subunits.


Pssm-ID: 460367  Cd Length: 84  Bit Score: 91.72  E-value: 9.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166226678    6 WNIVFHSLIGLRARVLATSDPGLRGLEGVVVEETRHSLVVETRDGRRVRVLKANSIFLFQLPGGSWVVVRGEEIAGSLAE 85
Cdd:pfam01868   1 AKLLKADLHGAEVEVVRSKNPSLVGIKGIVVDETKNTFVIITKDNRVKTIPKEGSVFRFELPDGEVVEIHGSQLLYRPED 80


                  ....
gi 166226678   86 RVKR 89
Cdd:pfam01868  81 RAKK 84
POP4 smart00538
A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes ...
 7-89 7.25e-19

A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins;


Pssm-ID: 197780  Cd Length: 92  Bit Score: 74.61  E-value: 7.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166226678     7 NIVFHSLIGLRARVLATSDPGLRGLEGVVVEETRHSLVVETRDGRRVRVLKANSIFLFQLPGGSWVVVRGEEIAGSLAER 86
Cdd:smart00538   5 KLLRHELIGLKVRVVASKNPSLVGIEGIVVDETRNTLVIETKEGRVKTVPKDGAVFEFELPGGEKVRIDGDLLVGRPEDR 84


                   ...
gi 166226678    87 VKR 89
Cdd:smart00538  85 SKK 87
PRK03879 PRK03879
ribonuclease P protein component 1; Validated
 1-89 7.60e-19

ribonuclease P protein component 1; Validated


Pssm-ID: 235169  Cd Length: 96  Bit Score: 74.59  E-value: 7.60e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166226678   1 MKRTAWNIVFHSLIGLRARVLATSDPGLRGLEGVVVEETRHSLVVETrDGRRVRVLKANSIFLFQLP--GGSWVVVRGEE 78
Cdd:PRK03879   1 MMITPSNILRHELIGLKVEVVDSTNPSLVGIKGRVVDETRNTLVIET-DGKEWMVPKDGATFEFELGrdDVVKVKVDGRL 79

                         90
                 ....*....|.
gi 166226678  79 IAGSLAERVKR 89
Cdd:PRK03879  80 LVGRPEDRLKK 90
 
Name Accession Description Interval E-value
POP4 COG1588
RNase P/RNase MRP subunit p29 [Translation, ribosomal structure and biogenesis];
2-96 3.69e-32

RNase P/RNase MRP subunit p29 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441196  Cd Length: 94  Bit Score: 108.38  E-value: 3.69e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166226678   2 KRTAWNIVFHSLIGLRARVLATSDPGLRGLEGVVVEETRHSLVVETRDGrRVRVLKANSIFLFQLPGGSWVVVRGEEIAG 81
Cdd:COG1588    1 MITPENILRHELIGLEVEVVESTNPSLVGISGRVVDETKNTLVIETEDG-VKRVPKSGATFEFTLPDGESVTVDGSLLLG 79

                         90
                 ....*....|....*
gi 166226678  82 SLAERVKRLGRLKGV 96
Cdd:COG1588   80 RPEERLKKLIKKKWR 94
RNase_P-MRP_p29 pfam01868
Ribonuclease P/MRP, subunit p29; This family consists of several archaeal and eukaryotic ...
 6-89 9.30e-26

Ribonuclease P/MRP, subunit p29; This family consists of several archaeal and eukaryotic proteins. The archaeal proteins are found to be expressed within ribosomal operons and several of the sequences are described as ribonuclease P protein subunit p29 proteins. The structure of the RNase P subunit, Rpp29, from Methanobacterium thermoautotrophicum has been determined. Mth Rpp29 is a member of the oligonucleotide/oligosaccharide binding fold family. It contains a structured beta-barrel core and unstructured N- and C-terminal extensions bearing several highly conserved amino acid residues that could be involved in RNA contacts in the protein-RNA complex. Rpp29 catalyzes the endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. It interacts with the Rpp25 and Pop5 subunits.


Pssm-ID: 460367  Cd Length: 84  Bit Score: 91.72  E-value: 9.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166226678    6 WNIVFHSLIGLRARVLATSDPGLRGLEGVVVEETRHSLVVETRDGRRVRVLKANSIFLFQLPGGSWVVVRGEEIAGSLAE 85
Cdd:pfam01868   1 AKLLKADLHGAEVEVVRSKNPSLVGIKGIVVDETKNTFVIITKDNRVKTIPKEGSVFRFELPDGEVVEIHGSQLLYRPED 80


                  ....
gi 166226678   86 RVKR 89
Cdd:pfam01868  81 RAKK 84
POP4 smart00538
A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes ...
 7-89 7.25e-19

A domain found in a protein subunit of human RNase MRP and RNase P ribonucleoprotein complexes and archaeal proteins;


Pssm-ID: 197780  Cd Length: 92  Bit Score: 74.61  E-value: 7.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166226678     7 NIVFHSLIGLRARVLATSDPGLRGLEGVVVEETRHSLVVETRDGRRVRVLKANSIFLFQLPGGSWVVVRGEEIAGSLAER 86
Cdd:smart00538   5 KLLRHELIGLKVRVVASKNPSLVGIEGIVVDETRNTLVIETKEGRVKTVPKDGAVFEFELPGGEKVRIDGDLLVGRPEDR 84


                   ...
gi 166226678    87 VKR 89
Cdd:smart00538  85 SKK 87
PRK03879 PRK03879
ribonuclease P protein component 1; Validated
 1-89 7.60e-19

ribonuclease P protein component 1; Validated


Pssm-ID: 235169  Cd Length: 96  Bit Score: 74.59  E-value: 7.60e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166226678   1 MKRTAWNIVFHSLIGLRARVLATSDPGLRGLEGVVVEETRHSLVVETrDGRRVRVLKANSIFLFQLP--GGSWVVVRGEE 78
Cdd:PRK03879   1 MMITPSNILRHELIGLKVEVVDSTNPSLVGIKGRVVDETRNTLVIET-DGKEWMVPKDGATFEFELGrdDVVKVKVDGRL 79

                         90
                 ....*....|.
gi 166226678  79 IAGSLAERVKR 89
Cdd:PRK03879  80 LVGRPEDRLKK 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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