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Conserved domains on  [gi|262828313|sp|A5FKD7|]
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RecName: Full=tRNA1(Val) (adenine(37)-N6)-methyltransferase; AltName: Full=tRNA m6A37 methyltransferase

Protein Classification

tRNA1(Val) (adenine(37)-N6)-methyltransferase( domain architecture ID 11467886)

tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase is a class I SAM-dependent methyltransferase that specifically methylates the adenine in position 37 of tRNA(1)(Val)

CATH:  2.20.25.110
EC:  2.1.1.223
Gene Ontology:  GO:0016430|GO:1904047|GO:0008170|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 1-231 6.20e-98

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 285.11  E-value: 6.20e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   1 MFQFKQFSVKQDKTAMKVGTDGVLLGSWAPVfHNPFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEA 80
Cdd:COG4123    5 GFLFKQFRIIQPRCGYRFGTDAVLLAAFAPV-KKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  81 SPWGDRLFCFHAGLDEFIEE-PEDEYDLIVSNPPFYAE--DYKTNDEQRDLARFQDAMPFEEIVEAADLLLSENGILAVI 157
Cdd:COG4123   84 NGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRFALI 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262828313 158 IPFKEEAKFTALAKDFELYPIKITRVKGTPKSEIKRSLLAFSRNEVSEIEI-DELVIEIDRHIYTPEYIDLTKEF 231
Cdd:COG4123  164 HPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRIlPPLVIHDEDGEYTPEVKALLRDF 238
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 1-231 6.20e-98

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 285.11  E-value: 6.20e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   1 MFQFKQFSVKQDKTAMKVGTDGVLLGSWAPVfHNPFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEA 80
Cdd:COG4123    5 GFLFKQFRIIQPRCGYRFGTDAVLLAAFAPV-KKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  81 SPWGDRLFCFHAGLDEFIEE-PEDEYDLIVSNPPFYAE--DYKTNDEQRDLARFQDAMPFEEIVEAADLLLSENGILAVI 157
Cdd:COG4123   84 NGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRFALI 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262828313 158 IPFKEEAKFTALAKDFELYPIKITRVKGTPKSEIKRSLLAFSRNEVSEIEI-DELVIEIDRHIYTPEYIDLTKEF 231
Cdd:COG4123  164 HPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRIlPPLVIHDEDGEYTPEVKALLRDF 238
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 33-182 9.42e-16

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 74.04  E-value: 9.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  33 HNPFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASpWGDRLFCFHAglDEFIEEPEDEYDLIVSNP 112
Cdd:PRK09328 107 KEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQG--DWFEPLPGGRFDLIVSNP 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313 113 PfYAEDYKTNDEQRDLARF---------QDAMPF-EEIVEAADLLLSENGILAVIIPFKEEAKFTALAKDFELYPIKITR 182
Cdd:PRK09328 184 P-YIPEADIHLLQPEVRDHephlalfggEDGLDFyRRIIEQAPRYLKPGGWLLLEIGYDQGEAVRALLAAAGFADVETRK 262
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 38-158 9.49e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.45  E-value: 9.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  38 ILDIGAGTGIIALMLAQRtHAEQIDALEIDEDAYEQAVENfEASPWGDRLFCFHAGLDEFIEEPEDEYDLIVSNPPFYAe 117
Cdd:cd02440    2 VLDLGCGTGALALALASG-PGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHH- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 262828313 118 dyktndEQRDLARFqdampFEEIVEaadlLLSENGILAVII 158
Cdd:cd02440   79 ------LVEDLARF-----LEEARR----LLKPGGVLVLTL 104
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 29-158 1.92e-12

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 63.38  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   29 APVFHNPFS--ILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASPwGDRLFCFHAGLDEfiEEPEDEYD 106
Cdd:pfam05175  24 LEHLPKDLSgkVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANG-LENGEVVASDVYS--GVEDGKFD 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 262828313  107 LIVSNPPFYAeDYKTNDeqrDLArfqdampfEEIVEAADLLLSENGILAVII 158
Cdd:pfam05175 101 LIISNPPFHA-GLATTY---NVA--------QRFIADAKRHLRPGGELWIVA 140
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 37-182 2.62e-12

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 64.41  E-value: 2.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   37 SILDIGAGTGIIALMLA-QRTHAeQIDALEIDEDAYEQAVENFEASpwGDRLFCFHAG--LDEFIEEPedeYDLIVSNPP 113
Cdd:TIGR03534  89 RVLDLGTGSGAIALALAkERPDA-RVTAVDISPEALAVARKNARRL--GLENVEFLQGdwFEPLPSGK---FDLIVSNPP 162

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262828313  114 fYAEDYKTNDEQRDLARF---------QDAMPF-EEIVEAADLLLSENGILAVIIPFKEEAKFTALAKDFELYPIKITR 182
Cdd:TIGR03534 163 -YIPEADIHLLDPEVRDFeprlalfggEDGLDFyRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETRK 240
rADc smart00650
Ribosomal RNA adenine dimethylases;
38-115 1.53e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 38.26  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313    38 ILDIGAGTGIIALMLAQRthAEQIDALEIDEDAYEQAVENFEASP-----WGDRLfcfhagldeFIEEPEDEYDLIVSNP 112
Cdd:smart00650  17 VLEIGPGKGALTEELLER--AKRVTAIEIDPRLAPRLREKFAAADnltviHGDAL---------KFDLPKLQPYKVVGNL 85


                   ...
gi 262828313   113 PFY 115
Cdd:smart00650  86 PYN 88
 
Name Accession Description Interval E-value
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 1-231 6.20e-98

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 285.11  E-value: 6.20e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   1 MFQFKQFSVKQDKTAMKVGTDGVLLGSWAPVfHNPFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEA 80
Cdd:COG4123    5 GFLFKQFRIIQPRCGYRFGTDAVLLAAFAPV-KKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  81 SPWGDRLFCFHAGLDEFIEE-PEDEYDLIVSNPPFYAE--DYKTNDEQRDLARFQDAMPFEEIVEAADLLLSENGILAVI 157
Cdd:COG4123   84 NGLEDRITVIHGDLKEFAAElPPGSFDLVVSNPPYFKAgsGRKSPDEARAIARHEDALTLEDLIRAAARLLKPGGRFALI 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262828313 158 IPFKEEAKFTALAKDFELYPIKITRVKGTPKSEIKRSLLAFSRNEVSEIEI-DELVIEIDRHIYTPEYIDLTKEF 231
Cdd:COG4123  164 HPAERLAEILAALRKYGLGPKRLRPVHPRPGKPAKRVLLEARKGGRAGLRIlPPLVIHDEDGEYTPEVKALLRDF 238
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 33-182 9.42e-16

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 74.04  E-value: 9.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  33 HNPFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASpWGDRLFCFHAglDEFIEEPEDEYDLIVSNP 112
Cdd:PRK09328 107 KEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQG--DWFEPLPGGRFDLIVSNP 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313 113 PfYAEDYKTNDEQRDLARF---------QDAMPF-EEIVEAADLLLSENGILAVIIPFKEEAKFTALAKDFELYPIKITR 182
Cdd:PRK09328 184 P-YIPEADIHLLQPEVRDHephlalfggEDGLDFyRRIIEQAPRYLKPGGWLLLEIGYDQGEAVRALLAAAGFADVETRK 262
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 35-156 1.09e-14

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 71.33  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  35 PFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGLDEFIEEPEdEYDLIVSNPPf 114
Cdd:COG2890  113 PPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPGDG-RFDLIVSNPP- 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 262828313 115 Y--AEDYKTNdeQRDLARF---------QDAMPF-EEIVEAADLLLSENGILAV 156
Cdd:COG2890  191 YipEDEIALL--PPEVRDHeprlaldggEDGLDFyRRIIAQAPRLLKPGGWLLL 242
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 38-116 2.61e-14

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 68.68  E-value: 2.61e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262828313  38 ILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASpwGDRLFCFHAGlDEFIEEPEDEYDLIVSNPPFYA 116
Cdd:COG2813   53 VLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAAN--GLENVEVLWS-DGLSGVPDGSFDLILSNPPFHA 128
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 38-158 9.49e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 62.45  E-value: 9.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  38 ILDIGAGTGIIALMLAQRtHAEQIDALEIDEDAYEQAVENfEASPWGDRLFCFHAGLDEFIEEPEDEYDLIVSNPPFYAe 117
Cdd:cd02440    2 VLDLGCGTGALALALASG-PGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEADESFDVIISDPPLHH- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 262828313 118 dyktndEQRDLARFqdampFEEIVEaadlLLSENGILAVII 158
Cdd:cd02440   79 ------LVEDLARF-----LEEARR----LLKPGGVLVLTL 104
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 29-158 1.92e-12

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 63.38  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   29 APVFHNPFS--ILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASPwGDRLFCFHAGLDEfiEEPEDEYD 106
Cdd:pfam05175  24 LEHLPKDLSgkVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANG-LENGEVVASDVYS--GVEDGKFD 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 262828313  107 LIVSNPPFYAeDYKTNDeqrDLArfqdampfEEIVEAADLLLSENGILAVII 158
Cdd:pfam05175 101 LIISNPPFHA-GLATTY---NVA--------QRFIADAKRHLRPGGELWIVA 140
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 37-182 2.62e-12

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 64.41  E-value: 2.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   37 SILDIGAGTGIIALMLA-QRTHAeQIDALEIDEDAYEQAVENFEASpwGDRLFCFHAG--LDEFIEEPedeYDLIVSNPP 113
Cdd:TIGR03534  89 RVLDLGTGSGAIALALAkERPDA-RVTAVDISPEALAVARKNARRL--GLENVEFLQGdwFEPLPSGK---FDLIVSNPP 162

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262828313  114 fYAEDYKTNDEQRDLARF---------QDAMPF-EEIVEAADLLLSENGILAVIIPFKEEAKFTALAKDFELYPIKITR 182
Cdd:TIGR03534 163 -YIPEADIHLLDPEVRDFeprlalfggEDGLDFyRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADVETRK 240
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 35-156 5.79e-11

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 60.99  E-value: 5.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   35 PFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAglDEFIEEPEDEYDLIVSNPPf 114
Cdd:TIGR03533 122 VKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAVAEINIERHGLEDRVTLIQS--DLFAALPGRKYDLIVSNPP- 198

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 262828313  115 yaedYKTNDEQRDLA---RFQDAMPFE----------EIVEAADLLLSENGILAV 156
Cdd:TIGR03533 199 ----YVDAEDMADLPaeyHHEPELALAsgedgldlvrRILAEAADHLNENGVLVV 249
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
37-111 4.16e-10

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 58.26  E-value: 4.16e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262828313  37 SILDIGAGTGIIAlMLAQRTHAEQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGLdefieEPEDEYDLIVSN 111
Cdd:COG2264  151 TVLDVGCGSGILA-IAAAKLGAKRVLAVDIDPVAVEAARENAELNGVEDRIEVVLGDL-----LEDGPYDLVVAN 219
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 38-111 9.07e-10

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.11  E-value: 9.07e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 262828313   38 ILDIGAGTGIIALMLAQRTHAeQIDALEIDEDAYEQAVENFEASpwGDRLFCFHAGLDEfIEEPEDEYDLIVSN 111
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGA-RVTGVDLSPEMLERARERAAEA--GLNVEFVQGDAED-LPFPDGSFDLVVSS 70
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
35-111 2.12e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 53.29  E-value: 2.12e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 262828313  35 PFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFeaspwgDRLFCFHAGLDEFieEPEDEYDLIVSN 111
Cdd:COG4106    2 PRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL------PNVRFVVADLRDL--DPPEPFDLVVSN 70
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 33-154 7.46e-09

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 54.67  E-value: 7.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   33 HNPFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGLDEFIeePEDEYDLIVSNP 112
Cdd:TIGR00536 113 PPILHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKNQLEHRVEFIQSNLFEPL--AGQKIDIIVSNP 190

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 262828313  113 PFYAEdyktndeqRDLARFQDAMPFE----------------EIVEAADLLLSENGIL 154
Cdd:TIGR00536 191 PYIDE--------EDLADLPNVVRFEpllalvggddglnilrQIIELAPDYLKPNGFL 240
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 35-169 1.75e-08

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 53.00  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  35 PFSILDIGAGTGIIALMLAQRTHAeQIDALEIDEDAYEQAVENFEASPWGDRLFcFHAGLDEFIEEPEDEYDLIVSNppf 114
Cdd:COG0500   27 GGRVLDLGCGTGRNLLALAARFGG-RVIGIDLSPEAIALARARAAKAGLGNVEF-LVADLAELDPLPAESFDLVVAF--- 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 262828313 115 yaedyktndeqrDLARFQDAMPFEEIVEAADLLLSENGILAVIIPFKEEAKFTAL 169
Cdd:COG0500  102 ------------GVLHHLPPEEREALLRELARALKPGGVLLLSASDAAAALSLAR 144
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
38-114 1.89e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 52.60  E-value: 1.89e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262828313  38 ILDIGAGTGIIAL--MLAQrthAEQIDALEIDEDAYEQAVENFEASpwGDRLFCFHAGLDEFieEPEDEYDLIVSNPPF 114
Cdd:COG2263   49 VLDLGCGTGMLAIgaALLG---AKKVVGVDIDPEALEIARENAERL--GVRVDFIRADVTRI--PLGGSVDTVVMNPPF 120
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 29-111 2.60e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 50.79  E-value: 2.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  29 APVFHNPFSILDIGAGTGIIALMLAQRTHaeQIDALEIDEDAYEQAVENFEASpwgdRLFCFHAGLDEFiEEPEDEYDLI 108
Cdd:COG2227   19 ARLLPAGGRVLDVGCGTGRLALALARRGA--DVTGVDISPEALEIARERAAEL----NVDFVQGDLEDL-PLEDGSFDLV 91


                 ...
gi 262828313 109 VSN 111
Cdd:COG2227   92 ICS 94
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
38-159 9.13e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 51.19  E-value: 9.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  38 ILDIGAGTGIIAlMLAQRTHAEQIDALEIDEDAYEQAVENFEASPWGDRLfcfhagldEFIEEPEDEYDLivsnppfyae 117
Cdd:COG4076   39 VLDIGTGSGLLS-MLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRI--------TVINADATDLDL---------- 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 262828313 118 dyktnDEQRDLA---RFQDAMPFEEIVE----AADLLLSENGIlavIIP 159
Cdd:COG4076  100 -----PEKADVIiseMLDTALLDEGQVPilnhARKRLLKPGGR---IIP 140
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 36-167 4.39e-07

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 49.86  E-value: 4.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  36 FSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGLDEFIEEpeDEYDLIVSNPPFY 115
Cdd:PRK01544 140 LNILELGTGSGCIAISLLCELPNANVIATDISLDAIEVAKSNAIKYEVTDRIQIIHSNWFENIEK--QKFDFIVSNPPYI 217

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262828313 116 AEDYK------TNDEQRDLARF--QDAM-PFEEIVEAADLLLSENGILAVIIPFKEEAKFT 167
Cdd:PRK01544 218 SHSEKsemaieTINYEPSIALFaeEDGLqAYFIIAENAKQFLKPNGKIILEIGFKQEEAVT 278
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 38-110 4.84e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.00  E-value: 4.84e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 262828313  38 ILDIGAGTGIIALMLAQRTHAeQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGLDEFieEPEDEYDLIVS 110
Cdd:COG2230   55 VLDIGCGWGGLALYLARRYGV-RVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDL--PADGQFDAIVS 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 37-111 8.61e-07

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.91  E-value: 8.61e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262828313  37 SILDIGAGTGIIALMLAQRTHaeQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGLDEFieePEDEYDLIVSN 111
Cdd:COG2226   25 RVLDLGCGTGRLALALAERGA--RVTGVDISPEMLELARERAAEAGLNVEFVVGDAEDLPF---PDGSFDLVISS 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
37-111 1.04e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 47.30  E-value: 1.04e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262828313  37 SILDIGAGTGIIALMLAQRthAEQIDALEIDEDAYEQAvenfEASPWGDRLfcFHAGLDEFiEEPEDEYDLIVSN 111
Cdd:COG4976   49 RVLDLGCGTGLLGEALRPR--GYRLTGVDLSEEMLAKA----REKGVYDRL--LVADLADL-AEPDGRFDLIVAA 114
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
37-111 1.53e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 47.84  E-value: 1.53e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 262828313  37 SILDIGAGTG---IIALMLAqrthAEQIDALEIDEDAYEQAVENFEASpwgdrlfcfHAGLDEFIEEPEDEYDLIVSN 111
Cdd:PRK00517 122 TVLDVGCGSGilaIAAAKLG----AKKVLAVDIDPQAVEAARENAELN---------GVELNVYLPQGDLKADVIVAN 186
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 39-111 1.82e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 45.05  E-value: 1.82e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 262828313   39 LDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGLDEFIEEPEDeYDLIVSN 111
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGS-FDVVVAS 72
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 33-119 7.48e-06

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 44.79  E-value: 7.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  33 HNPFSILDIGAGTGIIALMLAQRTHAE-QIDALEIDEDAYEQAVENFEASPWGDRLFcFHAG-----LDEFIEEPedeYD 106
Cdd:COG4122   15 LGAKRILEIGTGTGYSTLWLARALPDDgRLTTIEIDPERAAIARENFARAGLADRIR-LILGdalevLPRLADGP---FD 90

                         90
                 ....*....|....*
gi 262828313 107 LIV--SNPPFYAEDY 119
Cdd:COG4122   91 LVFidADKSNYPDYL 105
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
24-110 1.08e-05

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 44.82  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  24 LLGSWAPVFH-NPFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENF-EASPWGD--RLFCFHAglD--EF 97
Cdd:COG0421   26 MMAHVPLLFHpNPKRVLIIGGGDGGLARELLKHPPVERVDVVEIDPEVVELAREYFpLLAPAFDdpRLRVVIG--DgrAF 103

                         90
                 ....*....|...
gi 262828313  98 IEEPEDEYDLIVS 110
Cdd:COG0421  104 LREAEESYDVIIV 116
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 37-113 1.56e-05

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 45.17  E-value: 1.56e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 262828313  37 SILDIGAGTGIIALMLAQRthAEQIDALEIDEDAYEQAVENFEASPWGDRLFcFHAGLDEFI--EEPEDEYDLIVSNPP 113
Cdd:COG2265  236 RVLDLYCGVGTFALPLARR--AKKVIGVEIVPEAVEDARENARLNGLKNVEF-VAGDLEEVLpeLLWGGRPDVVVLDPP 311
PRK14968 PRK14968
putative methyltransferase; Provisional
 37-114 2.13e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 43.73  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  37 SILDIGAGTGIIALMLAQRthAEQIDALEIDEDAYEQAVENFEASPWGDRLFcfhagldEFIE----EP--EDEYDLIVS 110
Cdd:PRK14968  26 RVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRNNGV-------EVIRsdlfEPfrGDKFDVILF 96


                 ....
gi 262828313 111 NPPF 114
Cdd:PRK14968  97 NPPY 100
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 1-117 7.18e-05

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 42.48  E-value: 7.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313    1 MFQFKQFSVKQDKTAMKVGTD-GVLLGSWAPVFhNPFSILDIGAGTGIIALMLAQRTHAE-QIDALEIDEDAYEQAVENF 78
Cdd:pfam01596  10 LKELREETAKLPLAPMQVSPDeGQFLGMLVKLT-GAKNVLEIGVFTGYSALAMALALPEDgKITAIDIDPEAYEIAKKFI 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 262828313   79 EASPWGDRLFCFH----AGLDEFIEE-PEDEYDLIV-----SNPPFYAE 117
Cdd:pfam01596  89 QKAGVAHKISFILgpalKVLEQLTQDkPLPEFDFIFidadkSNYPNYYE 137
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 38-80 2.42e-04

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 40.84  E-value: 2.42e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 262828313  38 ILDIGAGTGIIALMLAQRthAEQIDALEIDEDAYEQAVENFEA 80
Cdd:COG2518   70 VLEIGTGSGYQAAVLARL--AGRVYSVERDPELAERARERLAA 110
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 23-114 2.65e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 40.42  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   23 VLLGSWAP--VFHNPFSildiGAGTGII--ALMLAQRTHAE-------QIDALEIDEDAYEQAVENFEASPWGDRLFcFH 91
Cdd:pfam01170  21 VNLAGWKPgdPLLDPMC----GSGTILIeaALMGANIAPGKfdarvraPLYGSDIDRRMVQGARLNAENAGVGDLIE-FV 95

                          90       100
                  ....*....|....*....|...
gi 262828313   92 AGLDEFIEEPEDEYDLIVSNPPF 114
Cdd:pfam01170  96 QADAADLPLLEGSVDVIVTNPPY 118
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 37-111 3.55e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 40.71  E-value: 3.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 262828313   37 SILDIGAGTGIIALMlAQRTHAEQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGldefiEEPEDEYDLIVSN 111
Cdd:pfam06325 164 SVLDVGCGSGILAIA-ALKLGAKKVVGVDIDPVAVRAAKENAELNGVEARLEVYLPG-----DLPKEKADVVVAN 232
PRK04338 PRK04338
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional
 21-79 6.38e-04

N(2),N(2)-dimethylguanosine tRNA methyltransferase; Provisional


Pssm-ID: 235286  Cd Length: 382  Bit Score: 40.28  E-value: 6.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  21 DGVLLGSWAPVFHNP----------------------FSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENF 78
Cdd:PRK04338  22 DGKFPPSWAPVFYNPrmelnrdisvlvlrafgpklprESVLDALSASGIRGIRYALETGVEKVTLNDINPDAVELIKKNL 101


                 .
gi 262828313  79 E 79
Cdd:PRK04338 102 E 102
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
99-159 8.65e-04

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 39.40  E-value: 8.65e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  99 EEPEDEYDLIVSNPPFYAEDYKTNDEQRDLARFQDAMP---------FEEIVEaadlLLSENGILAVIIP 159
Cdd:COG0286  115 GDELEKFDVVLANPPFGGKWKKEELKDDLLGRFGYGLPpksnadllfLQHILS----LLKPGGRAAVVLP 180
PRK14967 PRK14967
putative methyltransferase; Provisional
 38-157 1.02e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 39.27  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  38 ILDIGAGTGIIALMlAQRTHAEQIDALEIDEDAYEQAVENfeASPWGDRLFCFHAGLDEFIeePEDEYDLIVSNPPfYAE 117
Cdd:PRK14967  40 VLDLCTGSGALAVA-AAAAGAGSVTAVDISRRAVRSARLN--ALLAGVDVDVRRGDWARAV--EFRPFDVVVSNPP-YVP 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 262828313 118 DYKTNDEQRDLARFQDA-----MPFEEIVEAADLLLSENGILAVI 157
Cdd:PRK14967 114 APPDAPPSRGPARAWDAgpdgrAVLDRLCDAAPALLAPGGSLLLV 158
PRK06202 PRK06202
hypothetical protein; Provisional
 35-111 1.34e-03

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 38.83  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  35 PFSILDIGAGTGIIALMLAQRTHAE----QIDALEIDEDAYEQAVENFEASpwGDRLFCFHAglDEFIEEPEdEYDLIVS 110
Cdd:PRK06202  61 PLTLLDIGCGGGDLAIDLARWARRDglrlEVTAIDPDPRAVAFARANPRRP--GVTFRQAVS--DELVAEGE-RFDVVTS 135


                 .
gi 262828313 111 N 111
Cdd:PRK06202 136 N 136
rADc smart00650
Ribosomal RNA adenine dimethylases;
38-115 1.53e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 38.26  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313    38 ILDIGAGTGIIALMLAQRthAEQIDALEIDEDAYEQAVENFEASP-----WGDRLfcfhagldeFIEEPEDEYDLIVSNP 112
Cdd:smart00650  17 VLEIGPGKGALTEELLER--AKRVTAIEIDPRLAPRLREKFAAADnltviHGDAL---------KFDLPKLQPYKVVGNL 85


                   ...
gi 262828313   113 PFY 115
Cdd:smart00650  86 PYN 88
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 38-132 2.83e-03

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 38.52  E-value: 2.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  38 ILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENfeASPWGDRLFCFHAGLDEFIEEPEDEYDLIVSNPPfYAE 117
Cdd:PRK14966 255 VWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKN--AADLGARVEFAHGSWFDTDMPSEGKWDIIVSNPP-YIE 331

                         90
                 ....*....|....*
gi 262828313 118 DYKTNDEQRDLaRFQ 132
Cdd:PRK14966 332 NGDKHLLQGDL-RFE 345
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 34-210 3.33e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 37.65  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313   34 NPFSILDIGAGTGIIALMLAQRTHAEQIDALEIDEDAYEQAVENFEASpwgdrlFCFHAGLDEFIEEPEDEYDLIVSNpp 113
Cdd:TIGR02072  34 IPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSEN------VQFICGDAEKLPLEDSSFDLIVSN-- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  114 fyaedyktndeqrdlARFQDAMPFEEIVEAADLLLSENGILAviipfkeeakFTALAKDfELYPIK-ITRVKG---TPKS 189
Cdd:TIGR02072 106 ---------------LALQWCDDLSQALSELARVLKPGGLLA----------FSTFGPG-TLHELRqSFGQHGlryLSLD 159

                         170       180
                  ....*....|....*....|.
gi 262828313  190 EIKRSLLafsrNEVSEIEIDE 210
Cdd:TIGR02072 160 ELKALLK----NSFELLTLEE 176
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 39-111 4.46e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 35.33  E-value: 4.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 262828313   39 LDIGAGTGIIALMLAQRthAEQIDALEIDEDAYEQAVENFEASPwgdrlFCFHAGLDEFIEEPEDEYDLIVSN 111
Cdd:pfam08241   1 LDVGCGTGLLTELLARL--GARVTGVDISPEMLELAREKAPREG-----LTFVVGDAEDLPFPDNSFDLVLSS 66
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 66-117 5.31e-03

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 37.39  E-value: 5.31e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 262828313  66 IDEDAYEQAVENFEAspwgdrlfcfhAGLDEFIE---------EPEDEYDLIVSNPPfYAE 117
Cdd:COG0116  258 IDPRAIEAARENAER-----------AGVADLIEfeqadfrdlEPPAEPGLIITNPP-YGE 306
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 38-119 5.69e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 37.15  E-value: 5.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  38 ILDIGAGTGIIALMLAQRtHAEQIDALEIDEDAYEQAVENFEASPWGDRLFCFHAGLDEFIEEPEDEYDLIVSNPPFYAE 117
Cdd:COG2520  184 VLDMFAGVGPFSIPIAKR-SGAKVVAIDINPDAVEYLKENIRLNKVEDRVTPILGDAREVAPELEGKADRIIMNLPHSAD 262


                 ..
gi 262828313 118 DY 119
Cdd:COG2520  263 EF 264
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 38-115 8.03e-03

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 36.64  E-value: 8.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 262828313  38 ILDIGAGTGIIALMLAQRthAEQIDALEIDEDAYEQAVENFEASP-----WGDrlfcfhaGLD-EFIEEPEDEYDLIVSN 111
Cdd:COG0030   41 VLEIGPGLGALTRALLER--AARVTAVEIDRRLAAILRETFAAYPnltviEGD-------ALKvDLPALAAGEPLKVVGN 111


                 ....
gi 262828313 112 PPFY 115
Cdd:COG0030  112 LPYN 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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