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Conserved domains on  [gi|189040573|sp|A5N5W4|]
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RecName: Full=UPF0229 protein CKL_0641

Protein Classification

YeaH/YhbH family protein( domain architecture ID 11148708)

YeaH/YhbH family protein similar to Escherichia coli YeaH; belongs to the vWA (von Willebrand factor type A) domain superfamily

CATH:  3.40.50.410
SCOP:  3000832

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF444 pfam04285
Protein of unknown function (DUF444); Bacterial protein of unknown function. One family member ...
14-399 1.32e-173

Protein of unknown function (DUF444); Bacterial protein of unknown function. One family member is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA). Another family member YeaH is predicted to be part of a conserved signalling pathway with the kinase YeaG and the SpoVR protein YcgB. The pathway may be involved in nitrogen metabolism (see Supplementary note 5 in.)


:

Pssm-ID: 427839  Cd Length: 409  Bit Score: 490.49  E-value: 1.32e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   14 DRSLEDRRRHRQLVEKSIKDNLADIISEESIIGQSKNKKVKIPIKGIKEYQFIYG--DNSSGVGSGDGSQKKGDRIGKAI 91
Cdd:pfam04285   1 NKSAVNRQRFLRRVKEQIKKAVADAVSERSITDISKGEKISIPIKDISEPQFHYGsgGNREGVGPGNGEFVRGDRIGRPQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   92 KDRDGKGNQGAGNQ-EGEDMYEIEVTIEDVLDYLMEDLELPLMDKKKfSQILSNNSPKKSGYQRKGINPRLAKKRTVVEK 170
Cdd:pfam04285  81 GGGGGGGSGDGSDAgEGEDDFEFELSREEFLDLLFEDLELPDLVKKQ-LEVIEEFKTRRAGYTRSGSPSNLNVVRTMRNA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  171 LKRQQGTKR-ALREIH------------------GELESDPKNKLPENTTIKsRFPFKQD-DLRYFRVKRKPKLELNAAI 230
Cdd:pfam04285 160 LKRRIALGRpKRRELReleeelaelerrdgeddaEEIEELREEIERLRRRIR-RIPFIDPfDLRYRRFEKVPKPESNAVM 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  231 ICVMDTSGSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEEN 310
Cdd:pfam04285 239 FCLMDVSGSMDETKKDLAKRFFILLYLFLTRKYENVEVVFIRHHTSAKEVDEEEFFYSRESGGTVVSSALELMLEIIEER 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  311 YNPAYWNVYTFYVSDGDNWSEDNSLALK-CAKDLCKVCNLFSYAEIIPSPYGSSIKHIFQNKI-TDNNFTVVTIHEKQDL 388
Cdd:pfam04285 319 YPPSEWNIYAAQASDGDNWSDDNERCVElLAEKILPVCQYFAYIEITPYREHQTLWREYERVAaSDPNFAMRRIREKEDI 398
                         410
                  ....*....|.
gi 189040573  389 WKSLKKILNKE 399
Cdd:pfam04285 399 YPVFRELFKKE 409
 
Name Accession Description Interval E-value
DUF444 pfam04285
Protein of unknown function (DUF444); Bacterial protein of unknown function. One family member ...
14-399 1.32e-173

Protein of unknown function (DUF444); Bacterial protein of unknown function. One family member is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA). Another family member YeaH is predicted to be part of a conserved signalling pathway with the kinase YeaG and the SpoVR protein YcgB. The pathway may be involved in nitrogen metabolism (see Supplementary note 5 in.)


Pssm-ID: 427839  Cd Length: 409  Bit Score: 490.49  E-value: 1.32e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   14 DRSLEDRRRHRQLVEKSIKDNLADIISEESIIGQSKNKKVKIPIKGIKEYQFIYG--DNSSGVGSGDGSQKKGDRIGKAI 91
Cdd:pfam04285   1 NKSAVNRQRFLRRVKEQIKKAVADAVSERSITDISKGEKISIPIKDISEPQFHYGsgGNREGVGPGNGEFVRGDRIGRPQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   92 KDRDGKGNQGAGNQ-EGEDMYEIEVTIEDVLDYLMEDLELPLMDKKKfSQILSNNSPKKSGYQRKGINPRLAKKRTVVEK 170
Cdd:pfam04285  81 GGGGGGGSGDGSDAgEGEDDFEFELSREEFLDLLFEDLELPDLVKKQ-LEVIEEFKTRRAGYTRSGSPSNLNVVRTMRNA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  171 LKRQQGTKR-ALREIH------------------GELESDPKNKLPENTTIKsRFPFKQD-DLRYFRVKRKPKLELNAAI 230
Cdd:pfam04285 160 LKRRIALGRpKRRELReleeelaelerrdgeddaEEIEELREEIERLRRRIR-RIPFIDPfDLRYRRFEKVPKPESNAVM 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  231 ICVMDTSGSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEEN 310
Cdd:pfam04285 239 FCLMDVSGSMDETKKDLAKRFFILLYLFLTRKYENVEVVFIRHHTSAKEVDEEEFFYSRESGGTVVSSALELMLEIIEER 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  311 YNPAYWNVYTFYVSDGDNWSEDNSLALK-CAKDLCKVCNLFSYAEIIPSPYGSSIKHIFQNKI-TDNNFTVVTIHEKQDL 388
Cdd:pfam04285 319 YPPSEWNIYAAQASDGDNWSDDNERCVElLAEKILPVCQYFAYIEITPYREHQTLWREYERVAaSDPNFAMRRIREKEDI 398
                         410
                  ....*....|.
gi 189040573  389 WKSLKKILNKE 399
Cdd:pfam04285 399 YPVFRELFKKE 409
YeaH COG2718
Uncharacterized conserved protein YeaH/YhbH, required for sporulation, DUF444 family [General ...
1-403 1.04e-163

Uncharacterized conserved protein YeaH/YhbH, required for sporulation, DUF444 family [General function prediction only];


Pssm-ID: 442031  Cd Length: 385  Bit Score: 464.60  E-value: 1.04e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   1 MAIFREFDVNDHhDRSLEDRRRHRQLVEKSIKDNLADIISEESIIGQSKNKKVKIPIKGIKEYQFIYGDNSSGVGSGDGS 80
Cdd:COG2718    1 MSIIIDRRLNLK-RKSAVNRQRFLRRVKEAIKKAVADAVSEESIIDSDGGEKIKIPIRDLSEPRFRHGSGGKREHVGPGN 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  81 Q--KKGDRIGKAIKDRDGKGN-QGAGNQEGEDMYEIEVTIEDVLDYLMEDLELPLMDKKKFSQILSNnSPKKSGYQRKGI 157
Cdd:COG2718   80 GefVVGDRIGRPPGGGGGGGKgQAAGDGEGEDDFEFELSREEFLDLLFEDLELPNLVKKQLAEIEEE-KTRRAGFRKKGS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 158 NPRLAKKRTVVEKLKRQQGTKRalreihgelesdpknklpenttIKSRFPFKQDDLRYFRVKRKPKLELNAAIICVMDTS 237
Cdd:COG2718  159 PSNLDKKRTLREALKRRIAEGR----------------------IKRIPFIDPDDLRYRRWEKVPKPESNAVMFCLMDVS 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 238 GSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEENYNPAYWN 317
Cdd:COG2718  217 GSMGEFEKDLAKRFFFLLYLFLRRKYEKVEIVFIRHHTEAKEVDEEEFFHSGESGGTIVSSALELMLEIIEERYPPSDWN 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 318 VYTFYVSDGDNWSEDNSLALKCAKDLCKVCNLFSYAEIIPSPYGSSIKHIFQnKITDN--NFTVVTIHEKQDLWKSLKKI 395
Cdd:COG2718  297 IYAAQASDGDNWSSDNPRCVELLEELLPLCQYFGYGEITPYERGSTLWREYE-RIADEfpNFAMVRIREKEDIYPVFREL 375

                 ....*...
gi 189040573 396 LNKELEER 403
Cdd:COG2718  376 FKKEEAEA 383
spore_yhbH TIGR02877
sporulation protein YhbH; This protein family, typified by YhbH in Bacillus subtilis, is found ...
13-396 1.78e-160

sporulation protein YhbH; This protein family, typified by YhbH in Bacillus subtilis, is found in nearly every endospore-forming bacterium and in no other genome (but note that the trusted cutoff score is set high to exclude a single high-scoring sequence from Nitrosococcus oceani ATCC 19707, which is classified in the Gammaproteobacteria). The gene in Bacillus subtilis was shown to be in the regulon of the sporulation sigma factor, sigma-E, and its mutation was shown to create a sporulation defect. [Cellular processes, Sporulation and germination]


Pssm-ID: 274336  Cd Length: 371  Bit Score: 455.73  E-value: 1.78e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   13 HDRSLEDRRRHRQLVEKSIKDNLADIISEESIIGQSKNKKVKIPIKGIKEYQFIYG-DNSSGVGSGDGSQKKGDRIGKAI 91
Cdd:TIGR02877  11 HRKGGEDQERHQEKVEEAIKDNLPDIVSEESIIMSDGKKKIKVPIRGLKEYRFRYDwNKQKRVGQGDGNEKVGDVIGRER 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   92 KDRDGKGNQGAGNQEGEDMYEIEVTIEDVLDYLMEDLELPLMDKKKFSQILSNNSpKKSGYQRKGINPRLAKKRTVVEKL 171
Cdd:TIGR02877  91 AGGEGGGGKGAGDQEGEDYYETEVTLEELFELLFEDLELPNLKKKKFDEITTDSF-KFKDVRKKGLMPNLDKKRTVIEAL 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  172 KRQQGTKRAlreihgelesdpknklpenttikSRFPFKQDDLRYFRVKRKPKLELNAAIICVMDTSGSMDSTRKFLARSF 251
Cdd:TIGR02877 170 KRNQLRGRP-----------------------ELYPITKEDLRYKTWKENEKPESNAVVIAMMDTSGSMGQFKKYIARSF 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  252 FFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEENYNPAYWNVYTFYVSDGDNWSE 331
Cdd:TIGR02877 227 FFWMVKFLRTKYENVEICFISHHTEAKEVTEEEFFHKGESGGTYCSSGYKKALEIIDERYNPARYNIYAFHFSDGDNLTS 306
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189040573  332 DNSLALKCAKDLCKVCNLFSYAEIIPSPYGSSIKHIFQNKITDNNFTVVTIHEKQDLWKSLKKIL 396
Cdd:TIGR02877 307 DNERAVKLVRKLLEVCNLFGYGEIMPYGYSNTLKNKFKNEIKDPNFVPLIIRDKEDLYPALKKFL 371
PRK05325 PRK05325
hypothetical protein; Provisional
15-403 2.23e-158

hypothetical protein; Provisional


Pssm-ID: 235409  Cd Length: 401  Bit Score: 451.60  E-value: 2.23e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  15 RSLEDRRRHRQLVEKSIKDNLADIISEESIIGQSKNKKVKIPIKGIKEYQFIYGDNSSGVGSG--DGSQKKGDRIGKAIK 92
Cdd:PRK05325   1 KSLVDRQRFLRRVKEQIKKALPDAISERSIIDSDGGEVVSIPIRDIDEPKFRYGRGGKREGVGpgNGEFVVGDRIGRPQG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  93 DRDGKGnQGAGNQEGEDMYEIEVTIEDVLDYLMEDLELPLMDKKKFSQILSNnSPKKSGYQRKGINPRLAKKRTVVEKLK 172
Cdd:PRK05325  81 GGGGGG-QGGGDGEGEDYFEFEISLEELLDLLFEDLELPNLKKKGLKEIEEE-KTRRAGYRRTGPPSNLDKKRTLREALK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 173 RQQGTKRA----LREIHGELESDPKN----KLPENTTIKSRFPFKQD-DLRYFRVKRKPKLELNAAIICVMDTSGSMDST 243
Cdd:PRK05325 159 RRIALGRPkrreLRELEEELEALEALeeieRLRALRAKIDRVPFIDPfDLRYRNWEKVPKPESQAVMFCLMDVSGSMDEA 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 244 RKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEENYNPAYWNVYTFYV 323
Cdd:PRK05325 239 EKDLAKRFFFLLYLFLRRKYENVEVVFIRHHTEAKEVDEEEFFYSRESGGTIVSSAYKLALEIIEERYPPAEWNIYAFQA 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 324 SDGDNWSEDNSLALKCA-KDLCKVCNLFSYAEIIPSP-YGSSIKHIFQN-KITDNNFTVVTIHEKQDLWKSLKKILNKEL 400
Cdd:PRK05325 319 SDGDNWSSDNPRCVELLrEELLPVCNYFAYIEVTPRAyRHQTLWREYERlQDTFPNFAMQRIRDKEDIYPVFRELFKKEA 398

                 ...
gi 189040573 401 EER 403
Cdd:PRK05325 399 AEA 401
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
228-345 8.12e-08

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 51.41  E-value: 8.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 228 AAIICVMDTSGSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVV----------TENEFFHKVE---SGGT 294
Cdd:cd00198    1 ADIVFLLDVSGSMGGEKLDKAKEALKALVSSLSASPPGDRVGLVTFGSNARVVlplttdtdkaDLLEAIDALKkglGGGT 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 189040573 295 YISSGLKKALEVIEENYNPAYWNVyTFYVSDGDNwSEDNSLALKCAKDLCK 345
Cdd:cd00198   81 NIGAALRLALELLKSAKRPNARRV-IILLTDGEP-NDGPELLAEAARELRK 129
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
230-345 3.76e-03

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 38.20  E-value: 3.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   230 IICVMDTSGSMDSTRKFLARSFffvLYRFIKMKY---NNVEVKFISHSTSAKVVTE-------NEFFHKVES------GG 293
Cdd:smart00327   2 VVFLLDGSGSMGGNRFELAKEF---VLKLVEQLDigpDGDRVGLVTFSDDARVLFPlndsrskDALLEALASlsyklgGG 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 189040573   294 TYISSGLKKALEVI---EENYNPAYWNVyTFYVSDGDNWSEDNSLaLKCAKDLCK 345
Cdd:smart00327  79 TNLGAALQYALENLfskSAGSRRGAPKV-VILITDGESNDGPKDL-LKAAKELKR 131
 
Name Accession Description Interval E-value
DUF444 pfam04285
Protein of unknown function (DUF444); Bacterial protein of unknown function. One family member ...
14-399 1.32e-173

Protein of unknown function (DUF444); Bacterial protein of unknown function. One family member is predicted to contain a von Willebrand factor (vWF) type A domain (Smart:VWA). Another family member YeaH is predicted to be part of a conserved signalling pathway with the kinase YeaG and the SpoVR protein YcgB. The pathway may be involved in nitrogen metabolism (see Supplementary note 5 in.)


Pssm-ID: 427839  Cd Length: 409  Bit Score: 490.49  E-value: 1.32e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   14 DRSLEDRRRHRQLVEKSIKDNLADIISEESIIGQSKNKKVKIPIKGIKEYQFIYG--DNSSGVGSGDGSQKKGDRIGKAI 91
Cdd:pfam04285   1 NKSAVNRQRFLRRVKEQIKKAVADAVSERSITDISKGEKISIPIKDISEPQFHYGsgGNREGVGPGNGEFVRGDRIGRPQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   92 KDRDGKGNQGAGNQ-EGEDMYEIEVTIEDVLDYLMEDLELPLMDKKKfSQILSNNSPKKSGYQRKGINPRLAKKRTVVEK 170
Cdd:pfam04285  81 GGGGGGGSGDGSDAgEGEDDFEFELSREEFLDLLFEDLELPDLVKKQ-LEVIEEFKTRRAGYTRSGSPSNLNVVRTMRNA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  171 LKRQQGTKR-ALREIH------------------GELESDPKNKLPENTTIKsRFPFKQD-DLRYFRVKRKPKLELNAAI 230
Cdd:pfam04285 160 LKRRIALGRpKRRELReleeelaelerrdgeddaEEIEELREEIERLRRRIR-RIPFIDPfDLRYRRFEKVPKPESNAVM 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  231 ICVMDTSGSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEEN 310
Cdd:pfam04285 239 FCLMDVSGSMDETKKDLAKRFFILLYLFLTRKYENVEVVFIRHHTSAKEVDEEEFFYSRESGGTVVSSALELMLEIIEER 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  311 YNPAYWNVYTFYVSDGDNWSEDNSLALK-CAKDLCKVCNLFSYAEIIPSPYGSSIKHIFQNKI-TDNNFTVVTIHEKQDL 388
Cdd:pfam04285 319 YPPSEWNIYAAQASDGDNWSDDNERCVElLAEKILPVCQYFAYIEITPYREHQTLWREYERVAaSDPNFAMRRIREKEDI 398
                         410
                  ....*....|.
gi 189040573  389 WKSLKKILNKE 399
Cdd:pfam04285 399 YPVFRELFKKE 409
YeaH COG2718
Uncharacterized conserved protein YeaH/YhbH, required for sporulation, DUF444 family [General ...
1-403 1.04e-163

Uncharacterized conserved protein YeaH/YhbH, required for sporulation, DUF444 family [General function prediction only];


Pssm-ID: 442031  Cd Length: 385  Bit Score: 464.60  E-value: 1.04e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   1 MAIFREFDVNDHhDRSLEDRRRHRQLVEKSIKDNLADIISEESIIGQSKNKKVKIPIKGIKEYQFIYGDNSSGVGSGDGS 80
Cdd:COG2718    1 MSIIIDRRLNLK-RKSAVNRQRFLRRVKEAIKKAVADAVSEESIIDSDGGEKIKIPIRDLSEPRFRHGSGGKREHVGPGN 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  81 Q--KKGDRIGKAIKDRDGKGN-QGAGNQEGEDMYEIEVTIEDVLDYLMEDLELPLMDKKKFSQILSNnSPKKSGYQRKGI 157
Cdd:COG2718   80 GefVVGDRIGRPPGGGGGGGKgQAAGDGEGEDDFEFELSREEFLDLLFEDLELPNLVKKQLAEIEEE-KTRRAGFRKKGS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 158 NPRLAKKRTVVEKLKRQQGTKRalreihgelesdpknklpenttIKSRFPFKQDDLRYFRVKRKPKLELNAAIICVMDTS 237
Cdd:COG2718  159 PSNLDKKRTLREALKRRIAEGR----------------------IKRIPFIDPDDLRYRRWEKVPKPESNAVMFCLMDVS 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 238 GSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEENYNPAYWN 317
Cdd:COG2718  217 GSMGEFEKDLAKRFFFLLYLFLRRKYEKVEIVFIRHHTEAKEVDEEEFFHSGESGGTIVSSALELMLEIIEERYPPSDWN 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 318 VYTFYVSDGDNWSEDNSLALKCAKDLCKVCNLFSYAEIIPSPYGSSIKHIFQnKITDN--NFTVVTIHEKQDLWKSLKKI 395
Cdd:COG2718  297 IYAAQASDGDNWSSDNPRCVELLEELLPLCQYFGYGEITPYERGSTLWREYE-RIADEfpNFAMVRIREKEDIYPVFREL 375

                 ....*...
gi 189040573 396 LNKELEER 403
Cdd:COG2718  376 FKKEEAEA 383
spore_yhbH TIGR02877
sporulation protein YhbH; This protein family, typified by YhbH in Bacillus subtilis, is found ...
13-396 1.78e-160

sporulation protein YhbH; This protein family, typified by YhbH in Bacillus subtilis, is found in nearly every endospore-forming bacterium and in no other genome (but note that the trusted cutoff score is set high to exclude a single high-scoring sequence from Nitrosococcus oceani ATCC 19707, which is classified in the Gammaproteobacteria). The gene in Bacillus subtilis was shown to be in the regulon of the sporulation sigma factor, sigma-E, and its mutation was shown to create a sporulation defect. [Cellular processes, Sporulation and germination]


Pssm-ID: 274336  Cd Length: 371  Bit Score: 455.73  E-value: 1.78e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   13 HDRSLEDRRRHRQLVEKSIKDNLADIISEESIIGQSKNKKVKIPIKGIKEYQFIYG-DNSSGVGSGDGSQKKGDRIGKAI 91
Cdd:TIGR02877  11 HRKGGEDQERHQEKVEEAIKDNLPDIVSEESIIMSDGKKKIKVPIRGLKEYRFRYDwNKQKRVGQGDGNEKVGDVIGRER 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   92 KDRDGKGNQGAGNQEGEDMYEIEVTIEDVLDYLMEDLELPLMDKKKFSQILSNNSpKKSGYQRKGINPRLAKKRTVVEKL 171
Cdd:TIGR02877  91 AGGEGGGGKGAGDQEGEDYYETEVTLEELFELLFEDLELPNLKKKKFDEITTDSF-KFKDVRKKGLMPNLDKKRTVIEAL 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  172 KRQQGTKRAlreihgelesdpknklpenttikSRFPFKQDDLRYFRVKRKPKLELNAAIICVMDTSGSMDSTRKFLARSF 251
Cdd:TIGR02877 170 KRNQLRGRP-----------------------ELYPITKEDLRYKTWKENEKPESNAVVIAMMDTSGSMGQFKKYIARSF 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  252 FFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEENYNPAYWNVYTFYVSDGDNWSE 331
Cdd:TIGR02877 227 FFWMVKFLRTKYENVEICFISHHTEAKEVTEEEFFHKGESGGTYCSSGYKKALEIIDERYNPARYNIYAFHFSDGDNLTS 306
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189040573  332 DNSLALKCAKDLCKVCNLFSYAEIIPSPYGSSIKHIFQNKITDNNFTVVTIHEKQDLWKSLKKIL 396
Cdd:TIGR02877 307 DNERAVKLVRKLLEVCNLFGYGEIMPYGYSNTLKNKFKNEIKDPNFVPLIIRDKEDLYPALKKFL 371
PRK05325 PRK05325
hypothetical protein; Provisional
15-403 2.23e-158

hypothetical protein; Provisional


Pssm-ID: 235409  Cd Length: 401  Bit Score: 451.60  E-value: 2.23e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  15 RSLEDRRRHRQLVEKSIKDNLADIISEESIIGQSKNKKVKIPIKGIKEYQFIYGDNSSGVGSG--DGSQKKGDRIGKAIK 92
Cdd:PRK05325   1 KSLVDRQRFLRRVKEQIKKALPDAISERSIIDSDGGEVVSIPIRDIDEPKFRYGRGGKREGVGpgNGEFVVGDRIGRPQG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573  93 DRDGKGnQGAGNQEGEDMYEIEVTIEDVLDYLMEDLELPLMDKKKFSQILSNnSPKKSGYQRKGINPRLAKKRTVVEKLK 172
Cdd:PRK05325  81 GGGGGG-QGGGDGEGEDYFEFEISLEELLDLLFEDLELPNLKKKGLKEIEEE-KTRRAGYRRTGPPSNLDKKRTLREALK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 173 RQQGTKRA----LREIHGELESDPKN----KLPENTTIKSRFPFKQD-DLRYFRVKRKPKLELNAAIICVMDTSGSMDST 243
Cdd:PRK05325 159 RRIALGRPkrreLRELEEELEALEALeeieRLRALRAKIDRVPFIDPfDLRYRNWEKVPKPESQAVMFCLMDVSGSMDEA 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 244 RKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVESGGTYISSGLKKALEVIEENYNPAYWNVYTFYV 323
Cdd:PRK05325 239 EKDLAKRFFFLLYLFLRRKYENVEVVFIRHHTEAKEVDEEEFFYSRESGGTIVSSAYKLALEIIEERYPPAEWNIYAFQA 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 324 SDGDNWSEDNSLALKCA-KDLCKVCNLFSYAEIIPSP-YGSSIKHIFQN-KITDNNFTVVTIHEKQDLWKSLKKILNKEL 400
Cdd:PRK05325 319 SDGDNWSSDNPRCVELLrEELLPVCNYFAYIEVTPRAyRHQTLWREYERlQDTFPNFAMQRIRDKEDIYPVFRELFKKEA 398

                 ...
gi 189040573 401 EER 403
Cdd:PRK05325 399 AEA 401
vWFA cd00198
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
228-345 8.12e-08

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


Pssm-ID: 238119 [Multi-domain]  Cd Length: 161  Bit Score: 51.41  E-value: 8.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 228 AAIICVMDTSGSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVV----------TENEFFHKVE---SGGT 294
Cdd:cd00198    1 ADIVFLLDVSGSMGGEKLDKAKEALKALVSSLSASPPGDRVGLVTFGSNARVVlplttdtdkaDLLEAIDALKkglGGGT 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 189040573 295 YISSGLKKALEVIEENYNPAYWNVyTFYVSDGDNwSEDNSLALKCAKDLCK 345
Cdd:cd00198   81 NIGAALRLALELLKSAKRPNARRV-IILLTDGEP-NDGPELLAEAARELRK 129
ViaA COG2425
Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain ...
226-335 2.58e-06

Uncharacterized conserved protein, contains a von Willebrand factor type A (vWA) domain [Function unknown];


Pssm-ID: 441973 [Multi-domain]  Cd Length: 263  Bit Score: 48.52  E-value: 2.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 226 LNAAIICVMDTSGSMDSTRKFLARsffFVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVE-----------SGGT 294
Cdd:COG2425  117 LEGPVVLCVDTSGSMAGSKEAAAK---AAALALLRALRPNRRFGVILFDTEVVEDLPLTADDGLEdaieflsglfaGGGT 193
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 189040573 295 YISSGLKKALEVIEEnynPAYWNVYTFYVSDGDNWSEDNSL 335
Cdd:COG2425  194 DIAPALRAALELLEE---PDYRNADIVLITDGEAGVSPEEL 231
YfbK COG2304
Secreted protein containing bacterial Ig-like domain and vWFA domain [General function ...
173-328 2.59e-04

Secreted protein containing bacterial Ig-like domain and vWFA domain [General function prediction only];


Pssm-ID: 441879 [Multi-domain]  Cd Length: 289  Bit Score: 42.40  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 173 RQQGTKRALREIHGELESDPKNKLPENTTIKSRFPFKQDDLRYFRVKRKPKLELNAAI-----ICVMDTSGSMDSTRKFL 247
Cdd:COG2304   32 LVGGEPPPAAAVRLEELVNFFPYDYPLPTGRLAQSPWNPQTRLLLVGLQPPKAAAEERpplnlVFVIDVSGSMSGDKLEL 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 248 ARSfffVLYRFIKMKYNNVEVKFISHSTSAKVVTENEFFHKVE-----------SGGTYISSGLKKALEVIEENYNPAYw 316
Cdd:COG2304  112 AKE---AAKLLVDQLRPGDRVSIVTFAGDARVLLPPTPATDRAkilaaidrlqaGGGTALGAGLELAYELARKHFIPGR- 187
                        170
                 ....*....|..
gi 189040573 317 NVYTFYVSDGDN 328
Cdd:COG2304  188 VNRVILLTDGDA 199
VWA_YIEM_type cd01462
VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
230-326 3.30e-04

VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Members of this subgroup have a conserved MIDAS motif, however, their biochemical function is not well characterised.


Pssm-ID: 238739 [Multi-domain]  Cd Length: 152  Bit Score: 40.79  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 230 IICVmDTSGSMDSTRKFLARSFFFVLYRFIKMKYNNVEVKFISHSTSAKVVTEN-------EFFHKVE-SGGTYISSGLK 301
Cdd:cd01462    4 ILLV-DQSGSMYGAPEEVAKAVALALLRIALAENRDTYLILFDSEFQTKIVDKTddleepvEFLSGVQlGGGTDINKALR 82
                         90       100
                 ....*....|....*....|....*
gi 189040573 302 KALEVIEenyNPAYWNVYTFYVSDG 326
Cdd:cd01462   83 YALELIE---RRDPRKADIVLITDG 104
vWA_subgroup cd01465
VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood ...
233-334 7.20e-04

VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known.


Pssm-ID: 238742 [Multi-domain]  Cd Length: 170  Bit Score: 39.95  E-value: 7.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 233 VMDTSGSMDSTRKFLARSFFFVLYRFIKMKYNnveVKFISHSTSAKVV------TENEFFHKV-----ESGGTYISSGLK 301
Cdd:cd01465    6 VIDRSGSMDGPKLPLVKSALKLLVDQLRPDDR---LAIVTYDGAAETVlpatpvRDKAAILAAidrltAGGSTAGGAGIQ 82
                         90       100       110
                 ....*....|....*....|....*....|...
gi 189040573 302 KALEVIEENYNPAYWNvYTFYVSDGDNWSEDNS 334
Cdd:cd01465   83 LGYQEAQKHFVPGGVN-RILLATDGDFNVGETD 114
VWA smart00327
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ...
230-345 3.76e-03

von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods.


Pssm-ID: 214621 [Multi-domain]  Cd Length: 175  Bit Score: 38.20  E-value: 3.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573   230 IICVMDTSGSMDSTRKFLARSFffvLYRFIKMKY---NNVEVKFISHSTSAKVVTE-------NEFFHKVES------GG 293
Cdd:smart00327   2 VVFLLDGSGSMGGNRFELAKEF---VLKLVEQLDigpDGDRVGLVTFSDDARVLFPlndsrskDALLEALASlsyklgGG 78
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 189040573   294 TYISSGLKKALEVI---EENYNPAYWNVyTFYVSDGDNWSEDNSLaLKCAKDLCK 345
Cdd:smart00327  79 TNLGAALQYALENLfskSAGSRRGAPKV-VILITDGESNDGPKDL-LKAAKELKR 131
ChlD COG1240
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ...
216-328 4.86e-03

vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism];


Pssm-ID: 440853 [Multi-domain]  Cd Length: 262  Bit Score: 38.38  E-value: 4.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189040573 216 FRVKRKPKLELNAAIICVMDTSGSMDSTRKF-LARSfffVLYRFIKMKYNNVEVKFISHSTSAKVVTE-----NEFFHKV 289
Cdd:COG1240   81 LAPLALARPQRGRDVVLVVDASGSMAAENRLeAAKG---ALLDFLDDYRPRDRVGLVAFGGEAEVLLPltrdrEALKRAL 157
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 189040573 290 ES----GGTYISSGLKKALEVIeENYNPAYwNVYTFYVSDGDN 328
Cdd:COG1240  158 DElppgGGTPLGDALALALELL-KRADPAR-RKVIVLLTDGRD 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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