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Conserved domains on  [gi|189037422|sp|A8MQ11|]
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PUTATIVE PSEUDOGENE: RecName: Full=Postmeiotic segregation increased 2-like protein 5; AltName: Full=Postmeiotic segregation increased protein 4; AltName: Full=Postmeiotic segregation increased protein 7; AltName: Full=Putative postmeiotic segregation increased 2 pseudogene 5

Protein Classification

ATP-binding protein( domain architecture ID 382)

ATP-binding protein containing histidine kinase-like ATPase domain, similar to Streptomyces subrutilus DNA gyrase an an essential bacterial enzyme that catalyzes the ATP-dependent negative super-coiling of double-stranded closed-circular DNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase super family cl00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 13-73 4.85e-19

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


The actual alignment was detected with superfamily member cd16926:

Pssm-ID: 469604 [Multi-domain]  Cd Length: 188  Bit Score: 78.25  E-value: 4.85e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189037422  13 DVTISTCHVSAKVGTRLVFDHDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKeFQRNIKK 73
Cdd:cd16926   98 RLTITTRTADDDVGTRLVVDGGGIIEEVKPAAAPVGTTVTVRDLFYNTPARRK-FLKSPKT 157
 
Name Accession Description Interval E-value
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 13-73 4.85e-19

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 78.25  E-value: 4.85e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189037422  13 DVTISTCHVSAKVGTRLVFDHDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKeFQRNIKK 73
Cdd:cd16926   98 RLTITTRTADDDVGTRLVVDGGGIIEEVKPAAAPVGTTVTVRDLFYNTPARRK-FLKSPKT 157
mutl TIGR00585
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 13-73 5.85e-14

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 66.51  E-value: 5.85e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189037422   13 DVTISTCHV-SAKVGTRLVFDhDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKeFQRNIKK 73
Cdd:TIGR00585 107 RLTITTKTSaADGLAYQALLE-GGMIESIKPAPRPVGTTVEVRDLFYNLPVRRK-FLKSPKK 166
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
14-65 1.66e-11

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 60.06  E-value: 1.66e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 189037422  14 VTISTCHVSAKVGTRLVFDHdGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHK 65
Cdd:COG0323  109 LTLTTRTAGAELGTRIEVEG-GKVVEVEPAAAPKGTTVEVRDLFFNTPARRK 159
mutL PRK00095
DNA mismatch repair endonuclease MutL;
13-69 2.25e-09

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 54.07  E-value: 2.25e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 189037422  13 DVTISTCHVSAKVGTRLVFdHDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKeFQR 69
Cdd:PRK00095 107 RLTLTSRTADAAEGWQIVY-EGGEIVEVKPAAHPVGTTIEVRDLFFNTPARRK-FLK 161
 
Name Accession Description Interval E-value
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 13-73 4.85e-19

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 78.25  E-value: 4.85e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 189037422  13 DVTISTCHVSAKVGTRLVFDHDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKeFQRNIKK 73
Cdd:cd16926   98 RLTITTRTADDDVGTRLVVDGGGIIEEVKPAAAPVGTTVTVRDLFYNTPARRK-FLKSPKT 157
mutl TIGR00585
DNA mismatch repair protein MutL; All proteins in this family for which the functions are ...
 13-73 5.85e-14

DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273155 [Multi-domain]  Cd Length: 312  Bit Score: 66.51  E-value: 5.85e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189037422   13 DVTISTCHV-SAKVGTRLVFDhDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKeFQRNIKK 73
Cdd:TIGR00585 107 RLTITTKTSaADGLAYQALLE-GGMIESIKPAPRPVGTTVEVRDLFYNLPVRRK-FLKSPKK 166
MutL COG0323
DNA mismatch repair ATPase MutL [Replication, recombination and repair];
14-65 1.66e-11

DNA mismatch repair ATPase MutL [Replication, recombination and repair];


Pssm-ID: 440092 [Multi-domain]  Cd Length: 515  Bit Score: 60.06  E-value: 1.66e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 189037422  14 VTISTCHVSAKVGTRLVFDHdGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHK 65
Cdd:COG0323  109 LTLTTRTAGAELGTRIEVEG-GKVVEVEPAAAPKGTTVEVRDLFFNTPARRK 159
mutL PRK00095
DNA mismatch repair endonuclease MutL;
13-69 2.25e-09

DNA mismatch repair endonuclease MutL;


Pssm-ID: 234630 [Multi-domain]  Cd Length: 617  Bit Score: 54.07  E-value: 2.25e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 189037422  13 DVTISTCHVSAKVGTRLVFdHDGKIIQKTPYPHPRGTTVSVKQLFSTLPVRHKeFQR 69
Cdd:PRK00095 107 RLTLTSRTADAAEGWQIVY-EGGEIVEVKPAAHPVGTTIEVRDLFFNTPARRK-FLK 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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