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Conserved domains on  [gi|172048118|sp|A8N286|]
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RecName: Full=Haditoxin; AltName: Full=Muscarinic toxin-like protein 3 homolog; Short=MTLP-3 homolog; Flags: Precursor

Protein Classification

acrosomal protein SP-10( domain architecture ID 10082210)

acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_snake_toxin cd00206
Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, ...
 22-85 8.07e-16

Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. This domain contains 60-75 amino acids that are fixed by 4-5 disulfide bridges and is nearly all beta sheets; it exists as either a monomer or a dimer. The snake toxin domain exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold), which also includes extracellular domain (ECD) found in Ly-6 antigen/uPA receptor-like (LU) superfamily.


:

Pssm-ID: 467061  Cd Length: 64  Bit Score: 65.06  E-value: 8.07e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 172048118 22 TKCYNHQSTTPETTEICPDSGYFCYKSSWIDGREG-RIERGCTFTCPELTPnGKYVYCCRRDKCN 85
Cdd:cd00206   1 LICYNCPSSTCPTTKTCPPGENLCYKKWWRDGPRGkRIERGCAATCPKPKP-GEKVKCCSTDKCN 64
 
Name Accession Description Interval E-value
TFP_snake_toxin cd00206
Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, ...
 22-85 8.07e-16

Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. This domain contains 60-75 amino acids that are fixed by 4-5 disulfide bridges and is nearly all beta sheets; it exists as either a monomer or a dimer. The snake toxin domain exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold), which also includes extracellular domain (ECD) found in Ly-6 antigen/uPA receptor-like (LU) superfamily.


Pssm-ID: 467061  Cd Length: 64  Bit Score: 65.06  E-value: 8.07e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 172048118 22 TKCYNHQSTTPETTEICPDSGYFCYKSSWIDGREG-RIERGCTFTCPELTPnGKYVYCCRRDKCN 85
Cdd:cd00206   1 LICYNCPSSTCPTTKTCPPGENLCYKKWWRDGPRGkRIERGCAATCPKPKP-GEKVKCCSTDKCN 64
 
Name Accession Description Interval E-value
TFP_snake_toxin cd00206
Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, ...
 22-85 8.07e-16

Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. This domain contains 60-75 amino acids that are fixed by 4-5 disulfide bridges and is nearly all beta sheets; it exists as either a monomer or a dimer. The snake toxin domain exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold), which also includes extracellular domain (ECD) found in Ly-6 antigen/uPA receptor-like (LU) superfamily.


Pssm-ID: 467061  Cd Length: 64  Bit Score: 65.06  E-value: 8.07e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 172048118 22 TKCYNHQSTTPETTEICPDSGYFCYKSSWIDGREG-RIERGCTFTCPELTPnGKYVYCCRRDKCN 85
Cdd:cd00206   1 LICYNCPSSTCPTTKTCPPGENLCYKKWWRDGPRGkRIERGCAATCPKPKP-GEKVKCCSTDKCN 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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