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Conserved domains on  [gi|469169|gb|AAA17519|]
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major hippocampal somatostatin receptor [Rattus norvegicus]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11610479)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
44-318 3.54e-177

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


:

Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 493.60  E-value: 3.54e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPaRGGEAVACNLHWPHPAW 203
Cdd:cd15973  81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTAT-RKGQAVACNLIWPHPAW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS 283
Cdd:cd15973 160 SAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFLPR 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   284 LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15973 240 LDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
 
Name Accession Description Interval E-value
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
44-318 3.54e-177

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 493.60  E-value: 3.54e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPaRGGEAVACNLHWPHPAW 203
Cdd:cd15973  81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTAT-RKGQAVACNLIWPHPAW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS 283
Cdd:cd15973 160 SAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFLPR 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   284 LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15973 240 LDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
60-307 5.18e-76

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 235.65  E-value: 5.18e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169      60 GNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLS 137
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFwLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     138 VDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAV-FVIYTFLLGF 216
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKPVsYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     217 LLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDA-----TVNHV 291
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELsrlldKALSV 240
                         250
                  ....*....|....*.
gi 469169     292 SLILSYANSCANPILY 307
Cdd:pfam00001 241 TLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
45-325 1.06e-38

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 141.45  E-value: 1.06e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     45 TIQCIYALVCLVGLVGNALVIFViLRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:PHA03087  42 ILIVVYSTIFFFGLVGNIIVIYV-LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRpaRGGEAVACNLHWPHPA-- 202
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTK--KDHETLICCMFYNNKTmn 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRavalraGWQQRRRSEKKItRLVLMVVTVFVLCWMPFYVVqllnLFVT 282
Cdd:PHA03087 199 WKLFINFEINIIGMLIPLTILLYCYSKILITLK------GINKSKKNKKAI-KLVLIIVILFVIFWLPFNVS----VFVY 267
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 469169    283 SLDATVN--------------HVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLR 325
Cdd:PHA03087 268 SLHILHFksgckavkyiqyalHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLM 324
 
Name Accession Description Interval E-value
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
44-318 3.54e-177

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 493.60  E-value: 3.54e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPaRGGEAVACNLHWPHPAW 203
Cdd:cd15973  81 INMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTAT-RKGQAVACNLIWPHPAW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS 283
Cdd:cd15973 160 SAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLFLPR 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   284 LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15973 240 LDATVNHASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-318 4.12e-161

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 453.07  E-value: 4.12e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15093   1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGeAVACNLHWPHP-- 201
Cdd:cd15093  81 INMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDG-SSACNMQWPEPaa 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15093 160 AWSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNVFV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   282 ----TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15093 240 qlpeTPALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
44-318 7.67e-147

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 417.01  E-value: 7.67e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15970   1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGeAVACNLHWPHPA- 202
Cdd:cd15970  81 INMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDG-SVACNMQMPEPSq 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 -WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15970 160 rWLAVFVVYTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFV 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   282 TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15970 240 GQHDATVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
44-318 2.90e-125

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 362.38  E-value: 2.90e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd14970   1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGeAVACNLHWPHPA- 202
Cdd:cd14970  81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGG-TISCNLQWPDPPd 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 -WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGW--QQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd14970 160 yWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLSTSgaREKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   280 FV----TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14970 240 LIdppeTLTVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
44-318 1.73e-115

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 337.16  E-value: 1.73e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15974   1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGgeavACNLHWPHP-- 201
Cdd:cd15974  81 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQPDLN----TCNISWPEPvs 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15974 157 VWSTAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIV 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   282 T----SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15974 237 IlpeePAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQSF 277
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
44-318 4.58e-113

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 331.04  E-value: 4.58e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15971   1 AFLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAvaCNLHWPHP-- 201
Cdd:cd15971  81 INQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSS--CTIIWPGEss 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15971 159 AWYTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   282 T-----SLDATVNHVsLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15971 239 SisptpGLKGMFDFV-VVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
44-318 1.73e-99

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 296.71  E-value: 1.73e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15972   1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrPARGGeavACNLHWPHPA- 202
Cdd:cd15972  81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGV-PGGMG---TCHIAWPEPAq 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 -WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVA--LRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd15972 157 vWRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRSSGrrVRATSTKRRGSERKVTRMVVIVVAAFVLCWLPFYALNIVNL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   280 FVTSLDAT----VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15972 237 VCPLPEEPslfgLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
48-318 4.88e-94

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 282.83  E-value: 4.88e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15094   5 VLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGeaVACNLHWPH----PAW 203
Cdd:cd15094  85 TSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGR--YSCTIVWPDssavNGQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 sAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV-- 281
Cdd:cd15094 163 -KAFTLYTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQVHLIFLpp 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   282 ----TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15094 242 gtdmPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
44-316 3.37e-83

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 255.07  E-value: 3.37e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASA-AALRHWPFGAVLCRAVLSVD 122
Cdd:cd15088   1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQfAIDGQWYFGEVMCKIITALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGeAVACNLHWPHPA 202
Cdd:cd15088  81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDG-TTFCYVSLPSPD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV- 281
Cdd:cd15088 160 DLYWFTIYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVNLAMn 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   282 --TSLDATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15088 240 rpTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
44-318 1.18e-81

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 250.94  E-value: 1.18e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15092   1 VTIVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRpaRGGEAVACNLHWPHPA- 202
Cdd:cd15092  81 YNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQ--VEDEEIECLVEIPTPQd 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 -WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMP---FYVVQLLN 278
Cdd:cd15092 159 yWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPiqiFVLAQGLG 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   279 LFVTS-LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15092 239 VQPSSeTAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
44-318 5.28e-81

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 249.48  E-value: 5.28e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15089   1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGeAVACNLHWPHPA- 202
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDG-AVVCMLQFPSPSw 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 -WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15089 160 yWDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   282 -----TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15089 240 didrrNPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
44-318 4.49e-80

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 247.17  E-value: 4.49e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15091   1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPA- 202
Cdd:cd15091  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDDDy 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 --WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15091 161 swWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEAL 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   281 VTSLDAT----VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15091 241 GSVSHSTaavsSYYFCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
44-318 1.62e-79

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 245.67  E-value: 1.62e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15090   1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGgeAVACNLHWPHPA- 202
Cdd:cd15090  81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQG--SIDCTLTFSHPSw 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 -WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15090 159 yWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   282 T---SLDATVN-HVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15090 239 TipeTTFQTVSwHFCIALGYTNSCLNPVLYAFLDENFKRCF 279
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
48-318 5.16e-76

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 236.79  E-value: 5.16e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVlsvdglNM 126
Cdd:cd15095   5 LIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVcCVPFTAALYATPSWVFGDFMCKFV------NY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSV------FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRP-ARGGEAVACNLHWP 199
Cdd:cd15095  79 MMQVtvqatcLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEgYWYGPQTYCREVWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIV---GKMRAVALRAGWQQRRRS---EKKITRLVLMVVTVFVLCWMPFYV 273
Cdd:cd15095 159 SKAFQKAYMIYTVLLTYVIPLAIIAVCYGLILrrlWRRSVDGNNQSEQLSERAlrqKRKVTRMVIVVVVLFAICWLPNHV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   274 VQLLNLFVTSLDAT-----VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15095 239 LNLWQRFDPNFPETyatyaLKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
60-307 5.18e-76

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 235.65  E-value: 5.18e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169      60 GNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLS 137
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFwLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     138 VDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAV-FVIYTFLLGF 216
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKPVsYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     217 LLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDA-----TVNHV 291
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELsrlldKALSV 240
                         250
                  ....*....|....*.
gi 469169     292 SLILSYANSCANPILY 307
Cdd:pfam00001 241 TLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
48-311 1.73e-71

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 224.86  E-value: 1.73e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLViPFSLVSLLLGRWWFGDALCKLLGFLQSVSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRParGGEAVACNLHWPHPAWSAV 206
Cdd:cd00637  83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYD--YGGYCCCCLCWPDLTLSKA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQ-------RRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd00637 161 YTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSsnssrrrRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDV 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   280 FVTSLDA---TVNHVSLILSYANSCANPILYGFLS 311
Cdd:cd00637 241 FGPDPSPlprILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
49-318 2.00e-70

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 222.31  E-value: 2.00e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15087   6 IYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRA--ATYRRPSVAKLINLGVWLASLLVTLPIAVFADT-RPARGGEAVACNLHWPHPAWSA 205
Cdd:cd15087  86 SIYFLTVMSVDRYLVVLATVRSrrMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVySNELGRKSCVLSFPSPESLWFK 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV---- 281
Cdd:cd15087 166 ASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVALTTdlpq 245
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   282 TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15087 246 TPLVIGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
44-318 6.40e-70

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 221.14  E-value: 6.40e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMK--TATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLS 120
Cdd:cd15098   1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADLFFLLfCVPFQATIYSLPEWVFGAFMCKFVHY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   121 VDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADT-RPARGGEAVACNLHWP 199
Cdd:cd15098  81 FFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLvHHWTASNQTFCWENWP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVaLRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd15098 161 EKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLHKK-LKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVE 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   280 F----VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15098 240 FgdfpLTQASFVLRITAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
44-318 5.75e-68

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 216.31  E-value: 5.75e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLfCMPLTLLENVYRPWVFGEVLCKAVPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGE-----AVACNLH 197
Cdd:cd14993  81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEpgtitIYICTED 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   198 WPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGK--------MRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWM 269
Cdd:cd14993 161 WPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRlwrrkppgDRGSANSTSSRRILRSKKKVARMLIVVVVLFALSWL 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   270 PFYVVQLLNLF-------VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14993 241 PYYVLSILLDFgplsseeSDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
48-318 7.30e-68

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 215.93  E-value: 7.30e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADeLFM--LSVPFVASAAALRHWPFGAVLCRAVLSVDGLN 125
Cdd:cd15203   5 LLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSD-LLLclVSLPFTLIYTLTKNWPFGSILCKLVPSLQGVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRaaTYRRPSVAKLINLGVWLASLLVTLPIAVFAD----TRPARGGEAVACNLHWPHP 201
Cdd:cd15203  84 IFVSTLTLTAIAIDRYQLIVYPTR--PRMSKRHALLIIALIWILSLLLSLPLAIFQElsdvPIEILPYCGYFCTESWPSS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRA-----VALRAGWQQRRRSE----KKITRLVLMVVTVFVLCWMPFY 272
Cdd:cd15203 162 SSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKrvkkkRGKRTLSSRRRRSElrrkRRTNRLLIAMVVVFAVCWLPLN 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   273 VVQLLNLFVTSLDATVNHVSLI------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15203 242 LFNLLRDFEPLPQIDGRHFYLIflichlIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
50-318 1.55e-66

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 212.51  E-value: 1.55e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd14982   7 YSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFrIYYYLNGGWWPFGDFLCRLTGLLFYINMYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIaVFADTRPARGGEAVAC-NLHWPHPAWSAVF 207
Cdd:cd14982  87 SILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPL-LLLRSTIAKENNSTTCfEFLSEWLASAAPI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIvgkMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV------ 281
Cdd:cd14982 166 VLIALVVGFLIPLLIILVCYSLI---IRALRRRSKQSQKSVRKRKALRMILIVLAVFLVCFLPYHVTRILYLLVrlsfia 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   282 ----TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14982 243 dcsaRNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
49-318 6.38e-66

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 210.79  E-value: 6.38e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd14971   6 FFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLfCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd14971  86 ASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAWPSRAHRRAF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALR-AGWQQRRRSEKKITRLVLMVVTVFVLCWMP---FYVVQLLNLF-VT 282
Cdd:cd14971 166 ALCTFLFGYLLPLLLICVCYAAMLRHLWRVAVRpVLSEGSRRAKRKVTRLVLVVVVLFAACWGPihaILLLVALGPFpLT 245
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   283 SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14971 246 YATYALRIWAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
49-318 2.64e-65

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 209.08  E-value: 2.64e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFViLRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd14974   6 LYALIFLLGLPGNGLVIWV-AGFKMKRTVNTVWFLNLALADFLFCLFLPFlIVYIAMGHHWPFGSVLCKLNSFVISLNMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPaRGGEAVACNLHWPHPAWS--- 204
Cdd:cd14974  85 ASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVT-HHNGRSCNLTCVEDYDLRrsr 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 --AVFVIyTFLLGFLLPVLAIGLCYLLIVGKMRavalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd14974 164 hkALTVI-RFLCGFLLPLLIIAICYSVIAVKLR--------RKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLELVAA 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   283 SLDATVNHVSLILS----YANSCANPILYGFLSDNFRRSF 318
Cdd:cd14974 235 AGLPEVVLLGLPLAtglaYFNSCLNPILYVFMGQDFRKRL 274
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
48-318 6.43e-65

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 207.84  E-value: 6.43e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAlRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd14984   5 VLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAA-DGWVFGSFLCKLVSALYTINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGgeAVACNLHWPH---PAWS 204
Cdd:cd14984  84 SGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENG--SSICSYDYPEdtaTTWK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLGFLLPVLAIGLCYLLIVgkmrAVALRAGWQQRRRSekkiTRLVLMVVTVFVLCWMPFYVVQLLNLFV--- 281
Cdd:cd14984 162 TLLRLLQNILGFLLPLLVMLFCYSRII----RTLLRARNHKKHRA----LRVIFAVVVVFFLCWLPYNIVLLLDTLQllg 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   282 ---------TSLDATVnHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14984 234 iisrscelsKSLDYAL-QVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
44-318 8.02e-63

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 202.99  E-value: 8.02e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLSVD 122
Cdd:cd14985   1 VVIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYdWPFGAFLCKVSSYVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPA 202
Cdd:cd14985  81 SVNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTACIMLYPHEA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQLLNlFVT 282
Cdd:cd14985 161 WHFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTGKNGRKR--RKSLKIIFALVVAFLVCWLPFHFFKFLD-FLA 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   283 SLDAtVNH------------VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14985 238 QLGA-IRPcfwelfldlglpIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-315 1.25e-62

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 202.29  E-value: 1.25e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:cd14999   1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRaaTYRRP-SVAKLINLGVWLASLLVTLPIAVFA--DTRPARGGEAVACNLHWPHP 201
Cdd:cd14999  81 TMHASIFTLTVMSTERYLAVVKPLD--TVKRSkSYRKLLAGVIWLLSLLLTLPMAIMIrlVTVEDKSGGSKRICLPTWSE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEK-KITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd14999 159 ESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLPKqKVLKMIFTIVLVFWACFLPFWIWQLLYLY 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   281 VTSLDAT------VNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd14999 239 SPSLSLSprtttyVNYLLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
44-318 1.72e-58

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 191.74  E-value: 1.72e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15096   1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFvVFCVPFTATDYVLPTWPFGDVWCKIVQYLV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTR-PARGGEAV-ACNLHWPH 200
Cdd:cd15096  81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVsYGFSSEAYsYCTFLTEV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMR--AVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLN 278
Cdd:cd15096 161 GTAAQTFFTSFFLFSYLIPLTLICVLYMLMLRRLRrqKSPGGRRSAESQRGKRRVTRLVVVVVVVFAICWLPIHIILLLK 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   279 LFV----TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15096 241 YYGvlpeTVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
44-318 2.61e-57

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 188.79  E-value: 2.61e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVD 122
Cdd:cd15192   1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEyHWPFGNFLCKIASALV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWP--H 200
Cdd:cd15192  81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTNITVCAFHYPsqN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWSAVFVIYTFLLGFLLPVLAIGLCYLLIvGKmravALRAGWQQRRRSEK--KITRLVLMVVTVFVLCWMPFYVVQLLN 278
Cdd:cd15192 161 STLLVGLGLMKNLLGFLIPFLIILTCYTLI-GK----ALKKAYEIQRNKPRndEIFKMIMAVVLFFFFCWIPHQIFTFLD 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   279 LFVTSLDATVNHVSLI----------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15192 236 VLIQLKVIQDCHIADIvdtampfticIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
49-318 2.33e-56

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 185.56  E-value: 2.33e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15001   5 VYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLlVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVA---CNLHWPHPAWS 204
Cdd:cd15001  85 CSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGVTvyhCQKAWPSTLYS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLGFLLPVLAIGLCYLlivgkmravalragwqqrRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF--VT 282
Cdd:cd15001 165 RLYVVYLAIVIFFIPLIVMTFAYA------------------RDTRKQVIKMLISVVVLFAVCWGPLLIDNLLVSFdvIS 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   283 SLDA-TVNHVSL---ILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15001 227 TLHTqALKYMRIafhLLSYANSCINPIIYAFMSKNFRSSF 266
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
49-316 3.69e-56

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 185.79  E-value: 3.69e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKmKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15339   6 FIGILCSTGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADLVHIIVMPFlIHQWARGGEWVFGSPLCTIITSLDTCNQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGG-EAVACNLHWPHPA-Wsa 205
Cdd:cd15339  85 ACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGlESCAFNLTSPDDVlW-- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 vFVIYTFLLGFLLPVLAIGLCYLLIVG------KMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd15339 163 -YTLYQTITTFFFPLPLILICYILILCytwemyRKNKKAGRYNTSIPRQRVMRLTKMVLVLVGVFLVSAAPYHVIQLVNL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   280 FVTSLDATVN---HVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15339 242 SVSQPTLAFYvsyYLSICLSYASSSINPFLYILLSGNFRK 281
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
48-318 6.51e-56

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 183.92  E-value: 6.51e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd14967   4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHWPHPawsaV 206
Cdd:cd14967  84 TASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLP-PLVGWRDETQPSVVDCECEFTPNK----I 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIVGkmraVALRagwqqrrrsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT--SL 284
Cdd:cd14967 159 YVLVSSVISFFIPLLIMIVLYARIFR----VARR---------ELKAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPpdCV 225
                       250       260       270
                ....*....|....*....|....*....|....
gi 469169   285 DATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14967 226 PPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
50-318 6.37e-55

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 182.44  E-value: 6.37e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15207   7 YSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVfCMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInlGVWLASLLVTLPIAVFADTRPA---RGGEAVACNLHWPHPAWSA 205
Cdd:cd15207  87 SVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIV--AIWVLALAIMIPQALVLEVKEYqffRGQTVHICVEFWPSDEYRK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIV----GKMRAVALRAGWQQRRRSEKK---ITRLVLMVVTVFVLCWMPFYVVQLLN 278
Cdd:cd15207 165 AYTTSLFVLCYVAPLLIIAVLYVRIGyrlwFKPVPGGGSASREAQAAVSKKkvrVIKMLIVVVVLFALSWLPLHTVTMLD 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   279 LFVtslDATVNHVSLI----------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15207 245 DFG---NLSPNQREVLyvyiypiahwLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
49-318 1.29e-54

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 181.50  E-value: 1.29e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILryAKMKTATN-IYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15116   6 IYSVVFVLGVLGNGLVIFITG--FKMKKTVNtVWFLNLAVADFLFTFFLPFSIAYTAMDfHWPFGRFMCKLNSFLLFLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVAC--NLHWPHPAWS 204
Cdd:cd15116  84 FTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIICfnNFSLSGDNSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 A-----------VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRavalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYV 273
Cdd:cd15116 164 PevnqlrnmrhqVMTITRFLLGFLIPFTIIICCYAAIVLKLK--------RNRLAKSSKPFKIIAAVIVTFFLCWAPYHI 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   274 VQLLNLFVTSLDATVNHVSL----ILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15116 236 LNLLEMEATRSPASVFKIGLpitsSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
49-318 8.32e-54

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 179.77  E-value: 8.32e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15927   6 LFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLtCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEA---VACNLHWPH--PA 202
Cdd:cd15927  86 VSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNqtiQICYPYPQElgPN 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLI----VGKMRAVALRAGWQQRR--RSEKKITRLVLMVVTVFVLCWMPFYVVQL 276
Cdd:cd15927 166 YPKIMVLLRFLVYYLIPLLIIGVFYVLMarhlIRSTRNIGSGQNQAAQRqiEARKKVAKTVLAFVVLFAVCWLPRHVFML 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   277 LNLFVTSLDATVNH-------VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15927 246 WFHFAPNGLVDYNAfwhvlkiVGFCLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
50-318 2.96e-53

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 178.37  E-value: 2.96e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15393   7 YGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLfSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRpsVAKLINLGVWLASLLVTLPIAVFADTR----PARGGEAVACNLHWPHPAWS 204
Cdd:cd15393  87 SVFTLTVIAVDRYRAVIHPLKARCSKK--SAKIIILIIWILALLVALPVALALRVEeltdKTNNGVKPFCLPVGPSDDWW 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAV-----ALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNl 279
Cdd:cd15393 165 KIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTkapgnAQDVRDDEILKNKKKVIKMLIIVVALFALCWLPLQTYNLLN- 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   280 FVTSLDATVNHVSLI------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15393 244 EIKPEINKYKYINIIwfcshwLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
49-318 3.86e-53

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 177.47  E-value: 3.86e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVAsAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15178   6 IYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWA-VSVVKGWIFGTFMCKLVSLLQEANFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVaKLINLGVWLASLLVTLPIAVFADT-RPARGGEAVACNLHWPHPA--WSA 205
Cdd:cd15178  85 GILLLACISVDRYLAIVHATRALTQKRHLV-KFVCAGVWLLSLLLSLPALLNRDAfKPPNSGRTVCYENLGNESAdkWRV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYllivGKMRAVALRAGWQQRRRSekkiTRLVLMVVTVFVLCWMPFYVVQLLNLF----- 280
Cdd:cd15178 164 VLRILRHTLGFLLPLVVMLFCY----GFTIKTLLQTRSFQKHRA----MRVIFAVVLAFLLCWLPYNVTVLIDTLmrtkl 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   281 VTSLDATVNHVSL------ILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15178 236 ITETCELRNHVDValyvtqILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
44-318 2.34e-52

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 175.77  E-value: 2.34e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMK---TATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVL 119
Cdd:cd15338   1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFlIHQLLGNGVWHFGETMCTLIT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   120 SVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGeAVACNLHWP 199
Cdd:cd15338  81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDG-SVGCALLLP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAV-FVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLN 278
Cdd:cd15338 160 NPETDTYwFTLYQFFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAH 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   279 LFVTSLDATVNH---VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15338 240 LSIDRPSLAFLYaynVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
46-318 5.14e-52

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 174.57  E-value: 5.14e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAlRHWPFGAVLCRAVLSVDGLN 125
Cdd:cd15173   3 LPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAA-HEWIFGTVMCKITNGLYTIN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATY--RRPSVAKLINLGVWLASLLVTLPIAVFADTRPArggEAVACNLHWPHPAW 203
Cdd:cd15173  82 LYSSMLILTCITVDRFIVIVQATKAHNChaKKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNL---SSKICSMVYPPDAI 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMravaLRAGWQQRRRSekkiTRLVLMVVTVFVLCWMPFYVVQLLNLFVTS 283
Cdd:cd15173 159 EVVVNIIQMTVGFFLPLLAMIICYSVIIKTL----LHAKGFQKHKS----LKIIFVVVAVFILTQLPYNIMKLIRTLHIE 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   284 LDATVNHVSLIL-----SYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15173 231 NTDSTNFKYAILiteaiAYLHACLNPILYAFVGVKFRKNF 270
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
44-318 3.01e-51

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 173.07  E-value: 3.01e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTA--TNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLS 120
Cdd:cd14976   1 NLVSVVYMVVFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYALDFvWPFGTAMCKVVRY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   121 VDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAvACNLHWPH 200
Cdd:cd14976  81 VTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSVNHT-LCLLRFPK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PA-------WSAVFVIYTFLLGFLLPVLAIGLCYLLIVgkmRAVALRAGWQQRRRSekKITRLVLMVVTVFVLCWMPFYV 273
Cdd:cd14976 160 NSsvtrwynWLGMYQLQKVVLGFFLPLGIITLSYLLLL---RFLQRKRGGSKRRKS--RVTKSVFIVVLSFFICWLPNQA 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   274 VQLLNLFVTSLDATVNH-----------VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14976 235 LSLWSALIKFDDVPFSDaffafqtyafpVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
46-318 5.03e-50

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 169.55  E-value: 5.03e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLSVDGL 124
Cdd:cd15191   3 IPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYnWLFGSVMCKICGSLLTL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATyRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWP---HP 201
Cdd:cd15191  83 NLFASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTYYIEELGVNACIMAFPnekYA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAValrAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF- 280
Cdd:cd15191 162 QWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKT---KGFGKNKQRRDKVLKMVAAVVLAFLICWFPFHVLTFLDALa 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   281 ----------VTSLDATVNhVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15191 239 rmgvinncwvITVIDKALP-FAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
44-315 5.69e-50

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 168.79  E-value: 5.69e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVIlrYAKMKTATN-IYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSV 121
Cdd:cd15115   1 ILSLVVLSLTFLLGVPGNGLVIWVA--GLKMKRTVNtIWFLNLAVADLLCCLSLPFSIAHLLLNgHWPYGRFLCKLLPSI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrpARGGEAVACNLHwphp 201
Cdd:cd15115  79 IVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTT--VTDGNHTRCGYD---- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 aWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAvalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15115 153 -FLVAITITRAVFGFLLPLLIIAACYSFIAFRMQR-------GRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGILSLYG 224
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   282 TSLDATV----NHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15115 225 DPPLSKVlmswDHLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
49-316 5.69e-50

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 169.42  E-value: 5.69e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15168   6 VYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFlIYYYANGDHWIFGDFMCKLVRFLFYFNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFAdtRPARGGEAVACNLHWPHPAWSAvF 207
Cdd:cd15168  86 GSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFA--TTGRKNNRTTCYDTTSPEELND-Y 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIY---TFLLGFLLPVLAIGLCYLLIVgkmRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSL 284
Cdd:cd15168 163 VIYsmvLTGLGFLLPLLIILACYGLIV---RALIRKLGEGVTSALRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   285 DATVN-----------HVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15168 240 SGTAScatlngiyvayKVTRPLASLNSCLNPLLYFLAGDKFRR 282
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-315 4.45e-49

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 167.63  E-value: 4.45e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRY-AKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSV 121
Cdd:cd15190  11 ALIPVIYMLVFVLGLSGNGLVLWTVFRSkRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGyHWPFGSFLCKLSSYL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWP-- 199
Cdd:cd15190  91 VFVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVICDMDYSgv 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 -----HPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIvGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVV 274
Cdd:cd15190 171 vsnesEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFI-GRTVARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFHLV 249
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   275 Q----LLNLFVTSLDATVNHVSLI-------LSYANSCANPILYGFLSDNFR 315
Cdd:cd15190 250 KtlyaLMYLGILPFSCGFDLFLMNahpyatcLAYVNSCLNPFLYAFFDPRFR 301
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
45-316 2.82e-48

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 164.94  E-value: 2.82e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYA-LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVD 122
Cdd:cd15381   1 TFQPIYLwIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGfNWPFGEFLCKSVNAVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPA 202
Cdd:cd15381  81 YMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLDYPSEG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQrrRSEKKITRLVLMVVTVFVLCWMPFYV------VQL 276
Cdd:cd15381 161 WHVALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKFKEI--QTERKATVLVLAVLLMFFICWLPFHIftfldtLHK 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   277 LNLFVTSLDATV----NHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15381 239 LGLISGCRWEDIldigTQIATFLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
44-318 4.59e-48

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 164.10  E-value: 4.59e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15206   1 ELIIPLYSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPA 202
Cdd:cd15206  81 AVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPGGHKCREVWPNEI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAvalragwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd15206 161 AEQAWYVFLDLMLLVIPGLVMSVAYGLISWTLLE------------AKKRVIRMLFVIVVEFFICWTPLYVINTWKAFDP 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   283 S-----LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15206 229 PsaaryVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
48-318 6.69e-48

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 164.39  E-value: 6.69e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15390   5 IVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLIsAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRpsVAKLINLGVWLASLLVTLPIAVFADT---RPARGGEAVACNLHWP-HPA 202
Cdd:cd15390  85 AASVFTLMAISIDRYIAIVHPLRPRLSRR--TTKIAIAVIWLASFLLALPQLLYSTTetyYYYTGSERTVCFIAWPdGPN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFV--IYTFLLGFLLPVLAIGLCYLLIvgkmrAVALRAG---------WQQRRRSEKKITRLVLMVVTVFVLCWMPF 271
Cdd:cd15390 163 SLQDFVynIVLFVVTYFLPLIIMAVAYTRV-----GVELWGSktigentprQLESVRAKRKVVKMMIVVVVIFAICWLPY 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 469169   272 YVVQLLNLFVTSLdATVNHVSLI------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15390 238 HLYFILTYLYPDI-NSWKYIQQIylaiywLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
49-318 6.96e-48

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 164.07  E-value: 6.96e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVA-SAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15392   6 MYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMaVFCVPFSFiALLILQYWPFGEFMCPVVNYLQAVSV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRpsVAKLINLGVWLASLLVTLPIAVFA--DTRPARGGEAVACNLHWPHPAWS 204
Cdd:cd15392  86 FVSAFTLVAISIDRYVAIMWPLRPRMTKR--QALLLIAVIWIFALATALPIAITSrlFEDSNASCGQYICTESWPSDTNR 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLGFLLPVLAIGLCYLLIVGKM-------RAVALRAgwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLl 277
Cdd:cd15392 164 YIYSLVLMILQYFVPLAVLVFTYTRIGIVVwakrtpgEAENNRD--QRMAESKRKLVKMMITVVAIFALCWLPLNILNL- 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   278 nlfVTSLDATVNHVSLI---------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15392 241 ---VGDHDESIYSWPYIpylwlaahwLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
53-316 7.93e-48

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 163.79  E-value: 7.93e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    53 VCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVA-SAAALRHWPFGAVLCRAVLSVDGLNMFTSVF 131
Cdd:cd15189  10 LCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAmNILNQFNWPFGELLCRVVNGVIKVNLYTSIY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   132 CLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYT 211
Cdd:cd15189  90 LLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNITACVLLYPHEAWHFAHIVLL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   212 FLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWqqRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF--VTSLDAT-- 287
Cdd:cd15189 170 NIVGFLLPLLVITFCNYNILQALRTREESTRC--EDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLfdVGVLDECfw 247
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   288 ------VNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15189 248 ehfidiGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
44-318 3.05e-47

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 162.30  E-value: 3.05e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKM-KTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSV 121
Cdd:cd15097   1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILfCVPFQATIYSLEGWVFGSFLCKAVHFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARggeavacNLHWPHP 201
Cdd:cd15097  81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYA-------NSTVCMP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSA----VFVIYTFLLGFLLPVLAIGLCYLLIVGKM-RAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL 276
Cdd:cd15097 154 GWEEarrkAMDTCTFAFGYLIPVLVVSLSYTRTIKYLwTAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVIL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   277 LNLF----VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15097 234 CYLYgdfpFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
44-317 4.96e-47

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 161.97  E-value: 4.96e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVI-LRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSV 121
Cdd:cd15925   1 ILVALAYGLVCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDfHWPFGGAMCKMVLTA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEavACNLHWPHP 201
Cdd:cd15925  81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVE--LCLLKFPSN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAvalRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15925 159 YWLGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQ---HKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   282 T-----------SLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15925 236 KfravpwnstfyFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQA 282
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
49-318 7.24e-47

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 161.03  E-value: 7.24e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKmKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15114   6 LYAVVFLVGVPGNALVAWVTGFEAK-RSVNAVWFLNLAVADLLCCLSLPILAVPIAQDgHWPFGAAACKLLPSLILLNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15114  85 ASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKTVCVVDYGGSTGVEWA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 V-IYTFLLGFLLPVLAIGLCYllivgkmrAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL--------N 278
Cdd:cd15114 165 VaIIRFLLGFLGPLVVIASCH--------GVLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLIiaasapnsR 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   279 LFVTSLDATVNHVSliLSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15114 237 LLANALKADPLTVS--LAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
49-318 8.67e-47

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 161.44  E-value: 8.67e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILrYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15117   6 IYSSAFVLGTLGNGLVIWVTG-FRMTRTVTTVCFLNLAVADFAFCLFLPFsVVYTALGFHWPFGWFLCKLYSTLVVFNLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRpaRGGEAVACNLHWPHPAWSAV- 206
Cdd:cd15117  85 ASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTR--KENGCTHCYLNFDPWNETAEd 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 --------------FVIYTFLLGFLLPVLAIGLCYLLIVGKMravaLRAGWQQRRRSekkiTRLVLMVVTVFVLCWMPFY 272
Cdd:cd15117 163 pvlwletvvqrlsaQVITRFVLGFLVPLVIIGGCYGLIAARL----WREGWVHSSRP----FRVLTAVVAAFFLCWFPFH 234
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 469169   273 VVQLLNLFVTSLDATVNHVSLI--------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15117 235 LVSLLELVVILNQKEDLNPLLIlllplsssLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
49-318 1.38e-45

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 158.14  E-value: 1.38e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelFMLSV---PFVASAAALRHWPFGAVLCRA---VLSVD 122
Cdd:cd14969   6 YLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALAD--LLMSVvgyPLSFYSNLSGRWSFGDPGCVIygfAVTFL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLnmfTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHW-PHP 201
Cdd:cd14969  84 GL---VSISTLAALAFERYLVIVRPLKAFRLSKRRALILI-AFIWLYGLFWALP-PLFGWSSYVPEGGGTSCSVDWySKD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGW-------QQRRRSEKKITRLVLMVVTVFVLCWMPFYVV 274
Cdd:cd14969 159 PNSLSYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARrknsaitKRTKKAEKKVAKMVLVMIVAFLIAWTPYAVV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   275 QLLNLF--VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14969 239 SLYVSFggESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
49-317 1.57e-45

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 157.62  E-value: 1.57e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALrHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15179   6 VYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAA-NWYFGNFLCKAVHVIYTVNLYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGgeAVACNLHWPHPA---WSA 205
Cdd:cd15179  85 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDD--RYICDRIYPEDTfelWVV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKmravaLRAGWQQRRRSEKKITrlVLMVVTVFVlCWMPFYVVQLLNLFV---- 281
Cdd:cd15179 163 AFRFQHILVGLVLPGLVILTCYCIIISK-----LSHSKGHQKRKALKTT--VILILAFFA-CWLPYYIGISIDTFMllei 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   282 ----TSLDATVN---HVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15179 235 ikqsCEMEQTVHkwiSITEALAFFHCCLNPILYAFLGAKFKTS 277
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
49-316 4.91e-45

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 156.45  E-value: 4.91e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAlRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15174   6 LYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAAS-SGWVFGTFLCKVVNSMYKINFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSV--AKLINLGVWLASLLVTLPIAVFADTRpaRGGEAVACNLHWPHPAWSAV 206
Cdd:cd15174  85 CMLLLTCISVDRYIAIVQATKAHNSKNKRLlySKLVCFFVWLLSTILSLPEILFSQSK--EEESVTTCTMVYPSNESNRF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFL---LGFLLPVLAIGLCYLLIVGKMravalragWQQRRRSEKKITRLVLMVVTVFVLCWMP---FYVVQLL--- 277
Cdd:cd15174 163 KVAVLALkvtVGFFLPFVVMVICYTLIIHTL--------LQAKRFQKHKALKVIIAVVTVFVLSQLPynsILLIKTInay 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   278 NLFVTSLDATVN-----HVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15174 235 NITITDCATSQNldiagQVTQSIAFLHSCLNPFLYVFVGVRFRK 278
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
49-315 5.73e-45

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 156.44  E-value: 5.73e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKmKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15119   6 IYIVAFVLGVPGNAIVIWVTGFKWK-KTVNTLWFLNLAIADFVFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVLNMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAV- 206
Cdd:cd15119  85 ASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELSINVTICFNNFHKHDGDLIVm 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 ----FVIYTFLLGFLLPVLAIGLCYLLIVGKMRavalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd15119 165 rhtiLVWVRFFFGFLFPLLTMVVCYSLLAIKVK--------RRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIH 236
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   283 S---LDATVNH---VSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15119 237 HssyLHNVLRAgipLATSLAFINSCLNPILYVLIGKKFK 275
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
44-318 1.07e-44

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 155.68  E-value: 1.07e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFvASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15181   1 VFIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPF-SVVESIAGWVFGTFLCKLVGAIHK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAW 203
Cdd:cd15181  80 LNFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNANRTSCSFHQYGIHE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFL---LGFLLPVLAIGLCYLLIVGKMRAvalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15181 160 SNWWLTSRFLyhvVGFFLPLLIMGYCYATIVVTLCQ-------SSRRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTL 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   281 V------------TSLDATVNhVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15181 233 DdlkavvkncklnDLLDAAIT-VTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
53-315 2.49e-44

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 154.96  E-value: 2.49e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    53 VCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNMFTSVF 131
Cdd:cd15380  10 ICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQfNWPFGNFLCRVISGVIKANLFISIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   132 CLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYT 211
Cdd:cd15380  90 LVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDLNISACILLFPHEAWHFARRVEL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   212 FLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL----------FV 281
Cdd:cd15380 170 NIVGFLLPLAAIVFFNFHIIASLRERTEESRKRCGGLKDTKATRLILTLVLMFLVCWTPYHFFAFLDFlfqveviqgcFW 249
                       250       260       270
                ....*....|....*....|....*....|....
gi 469169   282 TSLDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15380 250 EEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
49-318 3.09e-44

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 154.53  E-value: 3.09e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAlRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15172   6 IYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEA-HQWIFGNFSCKLLRGIYAINFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVA--KLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPA---- 202
Cdd:cd15172  85 GMLLLACISVDRYIAIVQATKSFRLRSRTLAysKLICAAVWLLAILISLPTFIFSEVYDFGLEEQYVCEPKYPKNStaim 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMravaLRAGWQQRRrsekKITRLVLMVVTVFVLCWMPFYVVQLL---NL 279
Cdd:cd15172 165 WKLLVLSLQVSLGFFIPLLVMIFCYSFIIKTL----LQAQNSQRH----KAVRVVVAVVLVFLVCQVPYNIVLLIeaiNL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   280 FVTSLDATVNHVSL------ILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15172 237 GEQQSCSSEKAVAYaktiteCLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
49-318 5.22e-44

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 153.97  E-value: 5.22e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRH--WPFGAVLCRAVLSVDGLN 125
Cdd:cd15204   6 VYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVaVFCLPFEMDYYVVRQrsWTHGDVLCAVVNYLRTVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRpsVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWP--HPAW 203
Cdd:cd15204  86 LYVSTNALLVIAIDRYLVIVHPLKPRMKRR--TACVVIALVWVVSLLLAIPSAVYSKTTPYANQGKIFCGQIWPvdQQAY 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKM--RAVALRAGWQQRR--RSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd15204 164 YKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVwfRRVPGQQTEQIRRrlRRRRRKVRLLVVILTAFVLCWAPYYGYAIVRD 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   280 FVTSLDATVNHvSLILSYA-------NSCANPILYGFLSDNFRRSF 318
Cdd:cd15204 244 FFPTLLSKEKL-NTTIFYIvealamsNSMINTVVYVAFNNNIRKYL 288
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
49-318 7.21e-44

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 154.03  E-value: 7.21e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAALRH-WPFGAVLC--RAVLSvdGL 124
Cdd:cd15134   6 IYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILgLPFELYTIWQQYpWVFGEVFCklRAFLS--EM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADT----RPARGGEAVA----CNL 196
Cdd:cd15134  84 SSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRIvyleYPPTSGEALEesafCAM 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   197 HWPHPAWSAVFVIYTFLLgFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRR-------SEKKITRLVLMVVTVFVLCWM 269
Cdd:cd15134 164 LNEIPPITPVFQLSTFLF-FIIPMIAIIVLYVLIGLQLRRSTLLRRGQRSVSggrrssqSRRTVLRMLVAVVVAFFICWA 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   270 PFYVVQLLNLFVTSLDATVN-------HVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15134 243 PFHAQRLLTVYAKNMTPPYLfinrilfYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
50-318 1.64e-43

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 152.66  E-value: 1.64e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15202   7 YSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRpsVAKLINLGVWLASLLVTLPIAVFADT---RPARGGEAVACNLHWPHPAWSA 205
Cdd:cd15202  87 SAYTLTAIAVDRYQAIMHPLKPRISKT--KAKFIIAVIWTLALAFALPHAICSKLetfKYSEDIVRSLCLEDWPERADLF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 --VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAV-----ALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL- 277
Cdd:cd15202 165 wkYYDLALFILQYFLPLLVISFAYARVGIKLWASnmpgdATTERYFALRRKKKKVIKMLMVVVVLFALCWLPFNIYVLLl 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   278 NLFVTSLDATVNHVSLI---LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15202 245 SSKPDYLIKTINAVYFAfhwLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
49-318 2.20e-43

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 152.18  E-value: 2.20e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAK--MKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLN 125
Cdd:cd15002   5 LLGVICLLGFAGNLMVIGILLNNARkgKPSLIDSLILNLSAADLLLLLfSVPFRAAAYSKGSWPLGWFVCKTADWFGHAC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSA 205
Cdd:cd15002  85 MAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVV-ASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLAHEFMS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL----LNLFV 281
Cdd:cd15002 164 AFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWVAWLwlihIKSSG 243
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   282 TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15002 244 SSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
49-316 4.74e-43

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 151.06  E-value: 4.74e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAlRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15184   6 LYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAA-NEWVFGNAMCKLLTGLYHIGFFS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFadTRPARGGEAVACNLHWP---HPAWSA 205
Cdd:cd15184  85 GIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIF--TKSQKEGSHYTCSPHFPpsqYQFWKN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIvgkmravaLRAGWQQRRRSEK-KITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSL 284
Cdd:cd15184 163 FQTLKMNILGLVLPLLVMIICYSGI--------LKTLLRCRNEKKRhKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   285 DAT----------VNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15184 235 GLNncsssnrldqAMQVTETLGMTHCCINPVIYAFVGEKFRS 276
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 1.13e-42

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 149.82  E-value: 1.13e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAaLRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15182   7 YYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYH-SSGWIFGEILCKAVTSIFYIGFYSS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPargGEAVACNLHWPHPAWSAVFvI 209
Cdd:cd15182  86 ILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMK---SDEDGSLCEYSSIKWKLGY-Y 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   210 YTFLLGFLLPVLAIGLCYLLIvgkmravaLRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF--VTSLDAT 287
Cdd:cd15182 162 YQQNLFFLIPLGIIVYCYVRI--------LQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLkdLTIPICE 233
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   288 VN-------HVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15182 234 CSkqldyafYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
44-318 1.40e-42

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 150.43  E-value: 1.40e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVI-LRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSV 121
Cdd:cd15926   1 IIISIVYSVVCALGLVGNLLVLYLMkSKQGWKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDfTWLFGKAMCKIVSYV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEavACNLHWPHP 201
Cdd:cd15926  81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEE--LCLVKFPDN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 A-----WSAVFVIYTFLLGFLLPVLAIGLCYLLIVgkmRAVALR--AGWQQRRRSekKITRLVLMVVTVFVLCWMP---- 270
Cdd:cd15926 159 RgnaqfWLGLYHAQKVLLGFLIPLGIISLCYLLLV---RFITDKniTGSSTKRRS--KVTKSVTIVVLSFFLCWLPnqal 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   271 --------FYVVQLLNLFVTSlDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15926 234 ttwgilikLNVVHFSYEYFTT-QVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
44-318 1.50e-42

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 150.20  E-value: 1.50e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVD 122
Cdd:cd15159   1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGfDWPFGDWLCRLTALLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPArgGEAVACnlhWPHPA 202
Cdd:cd15159  81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEM--GGRITC---MEYPN 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVF-----VIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL- 276
Cdd:cd15159 156 FEKIKrlpliLLGACVIGFGVPVGIILFCYSQITLKLCRTAKENPLTEKSGHHKKACNVILLVLLVFVVCFSPYHLNIIq 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   277 --------------LNLFVTSLdatvnHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15159 236 fmirkllyqpscseLKAFKISL-----QITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
44-318 1.94e-42

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 149.84  E-value: 1.94e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAlRHWPFGAVLCRAVLSVDG 123
Cdd:cd15180   1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAV-HGWIFGTGLCKLAGAVFK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPA- 202
Cdd:cd15180  80 INFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNKTECVHNFPQSDt 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 --WSAVFVIYTFlLGFLLPVLAIGLCYLLIVGKmravaLRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15180 160 ywWLALRLLYHI-VGFLLPLAVMVYCYTSILLR-----LLRSSQGFQK--QRAIRVIVAVVVVFFLCWTPYNIALLVDTL 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   281 V------------TSLDATVNhVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15180 232 IdlsvldrncgteSRLDIALS-VTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
44-318 2.78e-42

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 149.81  E-value: 2.78e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-FMLSVPF-VASAAALRHWPFGAVLCRAVLSV 121
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLiLLVGLPVeLYNFWWQYPWAFGDGGCKLYYFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGgeavacNLHWPHP 201
Cdd:cd14979  81 FEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNG------PLPGPVP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AW-------SAVFVIYTF----LLGFLLPVLAIGLCYLLIVGKMRAVAL-----------RAGWQQRRRSEKKITRLVLM 259
Cdd:cd14979 155 DSavctlvvDRSTFKYVFqvstFIFFVLPMFVISILYFRIGVKLRSMRNikkgtraqgtrNVELSLSQQARRQVVKMLGA 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   260 VVTVFVLCWMPFYVVQLLNLFVTSLDAT-------VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14979 235 VVIAFFVCWLPFHAQRLMFSYASKEDTFlfdfyqyLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 4.00e-42

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 149.46  E-value: 4.00e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15208   7 YILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIiCLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLR-AATYRRpsvAKLINLGVWLASLLVTLPIAVFADTRPARGGEA-----VACNLHWPHPA 202
Cdd:cd15208  87 SVLTLSCIALDRWYAICHPLMfKSTAKR---ARVSILIIWIVSLLIMIPQAIVMECSRVVPLANktillTVCDERWSDSI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIV-------------------GKMRAVALRAGWQQrRRSEKKITRLVLMVVTV 263
Cdd:cd15208 164 YQKVYHICFFLVTYLLPLCLMILAYFQIFrklwcrqipgtssvvqrkwNKPRKSAVAAEEKQ-LRSRRKTAKMLIVVVIM 242
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 469169   264 FVLCWMPFYVVQLL---NLFVTSLDATVNHVSLI---LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15208 243 FAICYLPVHLLNILryvFGLFTVDRETIYAWFLFshwLVYANSAINPIIYNFMSGKFREEF 303
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
46-315 5.09e-42

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 148.36  E-value: 5.09e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATnIYLLNLAVADELFMLSVPFVASAAAL-RHWPFGAVLCRAVLSVDGL 124
Cdd:cd15372   3 VPSLYTLVFLVGLPANGLALWVLATQVKRLPST-IFLINLAVADLLLILVLPFKISYHFLgNNWPFGEGLCRVVTAFFYG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWS 204
Cdd:cd15372  82 NMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLCHDVLPLDEQD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIY---TFLLGFLLPVLAIGLCYLLIvgkmravaLRAGWQQRRRSEKKItRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15372 162 TYLFYYfacLAVLGFLLPLVVILFCYGSV--------LHTLLRSGQRYGHAM-KLTVLVLVSFVLCFTPSNLLLLLHYSD 232
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   282 TSLDA-----TVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15372 233 PTLDDggnlyIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
45-315 6.41e-42

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 148.37  E-value: 6.41e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVP-FVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd14987   2 TLSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPvWVVSLVQHNQWPMGEFTCKITHLIFS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPA- 202
Cdd:cd14987  82 INLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETYCRSFYPEESf 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 --WSAVFVIYTFLLGFLLPVLAIGLCYLLIvgkmrAVALRAGWQQRRRSEKKItrlVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd14987 162 keWLIGMELVSIVLGFVIPFPIIAVFYFLL-----ARAISASSDQERKSSRKI---IFSYVVVFLVCWLPYHTVVLLDIL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   281 -----------VTSLDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd14987 234 sflhlipfscqLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
50-318 1.06e-41

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 147.96  E-value: 1.06e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADeLFM--LSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd14992   7 LVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISD-LLMalFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPAR---GGEAVACNLHWPHPAWS 204
Cdd:cd14992  86 ASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFsvkNQEKIFCCQIPPVDNKT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFV--IYTFLLGFLLPVLAIGLCYLLIVGKMRA-----VALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:cd14992 166 YEKVyfLLIFVVIFVLPLIVMTLAYARISRELWFrkvpgFSIKEVERKRLKCKRRVIKMLVCVVVLFVICWLPFHLFFLL 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   278 NLFVTSLDATVNHVSLI-----LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14992 246 RDFFPLIMKEKHTLQVYyflhwIAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
44-316 1.80e-41

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 147.21  E-value: 1.80e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLSVD 122
Cdd:cd15193   1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGqWLFGEGLCKLSSFII 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRparggEAVACnlhWPHPA 202
Cdd:cd15193  81 AVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLI-----NESVC---VEDSS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAV--FVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15193 153 SRFFqgISLATLFLTFVLPLIVILFCYCSILVRLRRHFHGAKRTGRRR--RNSLRIVFAIVTAFVLSWLPFNTLKAVRLL 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   281 VTSLDATVNH-----------VSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15193 231 LELGGGVLPChttvairqgltITACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
49-315 1.63e-40

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 144.52  E-value: 1.63e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVAsAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15175   6 MYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWA-ASAAKKWVFGEEMCKAVYCLYKMSFFS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSV--AKLINLGVWLASLLVTLPIAVFADTRpaRGGEAVACNLHWPH-PAWSA 205
Cdd:cd15175  85 GMLLLMCISIDRYFAIVQAASAHRHRSRAVfiSKVSSLGVWVLAFILSIPELLYSGVN--NNDGNGTCSIFTNNkQTLSV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMravalragWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD 285
Cdd:cd15175 163 KIQISQMVLGFLVPLVVMSFCYSVIIKTL--------LQARNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKG 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   286 ATVN-----------HVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15175 235 NTTDcdysknldfalDVTYSLACFRCCLNPFLYAFIGVKFR 275
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
49-316 2.48e-40

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 144.17  E-value: 2.48e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAaLRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15187   6 LYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYL-LDQWVFGNAMCKIVSGAYYIGFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFadTRPARGGEAVACNLHWPHPA--WSAV 206
Cdd:cd15187  85 SMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVF--YQVASEDGRLQCIPFYPGQGnsWKVF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIVGKMRAValragwqqRRRSEKKITRLVLMVVTVFVLCWMPFYVVqllnLFVTSLD- 285
Cdd:cd15187 163 TNFEVNILGLLIPFSILIFCYHNILRNLRRC--------HNQNKTKAIKLVFIVVIVFFLFWTPFNVV----LFLDSLHs 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   286 -------------ATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15187 231 lhiidgcqnsqrlTLALHLTETISFTHCCLNPVIYAFVGEKFKK 274
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
50-315 4.59e-40

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 143.73  E-value: 4.59e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15394   7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPLtLAYAFEPRGWVFGRFMCYFVFLMQPVTVY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVakLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15394  87 VSVFTLTAIAVDRYYVTVYPLRRRISRRTCA--YIVAAIWLLSCGLALPAAAHTYYVEFKGLDFSICEEFWFGQEKQRLA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFL-LGFLLPVLAIGLCYLLIVGKMR-------AVALRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd15394 165 YACSTLlITYVLPLLAISLSYLRISVKLRnrvvpgsMTQSQAEWDRARR--RKTFRLLVVVVVAFAICWLPLHIFNVIRD 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   280 FVTSLdATVNHVSLI------LSYANSCANPILYGFLSDNFR 315
Cdd:cd15394 243 IDIDL-IDKQYFNLIqllchwLAMSSACYNPFLYAWLHDSFR 283
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
48-316 5.25e-40

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 143.25  E-value: 5.25e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15389   5 VAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILItLLNTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATyrRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAV---ACNLHWPHPA- 202
Cdd:cd15389  85 YVSTLTLTAIALDRHRVILHPLKPRI--TPCQGVVVIAIIWIMASCLSLPHAIYQKLVEFEYSNERtrsRCLPSFPEPSd 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 -WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGK--MRAVALRAGWQQR---RRSEKKITRLVLMVVTVFVLCWMP--FYVV 274
Cdd:cd15389 163 lFWKYLDLATFILQYVLPLLIIGVAYTRVAKKlwLRNAIGDVTTEQYvaqRRKKKKTIKMLMLVVLLFAICWLPlnCYHV 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   275 qLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15389 243 -LLSSHPIRSNSALFFAFHWLAMSSTCYNPFIYCWLNDSFRS 283
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
49-318 1.81e-39

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 141.86  E-value: 1.81e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVIL--RYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15122   6 FLLLAALLGLPGNGFIIWSILwkMKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAV 206
Cdd:cd15122  86 YASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPCHASRGHAIF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIvgkmrAVALRAGWQQRRrseKKITRLVLMVVTVFVLCWMPFYVVQLL----NLFVT 282
Cdd:cd15122 166 HYTFETLVAFVLPFGVILFSYSVI-----LVRLKGARFRRR---ARVEKLIAAIVVAFALLWVPYHVVNLLqvvaNLAPG 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   283 SLDATVNHVSLI-------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15122 238 EVLEKLGGAAKAaragataLAFFSSSVNPLLYVFAAGDLIKTS 280
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
50-318 2.41e-39

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 141.50  E-value: 2.41e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15399   7 YCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVakLINLGVWLASLLVTLPIAVFADTRPAR---GGEAVACNLHWP--HPAW 203
Cdd:cd15399  87 STVTLTVIALDRHRCIVYHLESKISKKISF--LIIGLTWAASALLASPLAIFREYSVIEispDFKIQACSEKWPngTLND 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMR----AVALRAGWQQRRRsekKITRLVLMVVTVFVLCWMPFYVVQL--- 276
Cdd:cd15399 165 GTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKnhvsPGGGNDHYHQRRR---KTTKMLVCVVVVFAVSWLPFHAFQLasd 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   277 -----LNLFVTSLDATVNHVsliLSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15399 242 idskvLDLKEYKLIYTIFHV---IAMCSTFANPLLYGWMNNNYRTAF 285
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
50-315 3.07e-39

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 141.50  E-value: 3.07e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADeLFM--LSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15391   7 YQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSD-LIMalFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRA-ATYRRpsvAKLINLGVWLASL-LVTLPIAVFADTRPARGGEA-VACNLHWPHPAWS 204
Cdd:cd15391  86 ASVLTNTAIGIDRFFAVIFPLRSrHTKSR---TKCIIASIWAISFsLSSVQLFAGRTQRYGQYSEGrVLCGESWPGPDTS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AV-FVIYTFLLGFLLPVLAIGLCYlLIVGKM---RAV---ALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:cd15391 163 RSaYTVFVMLLTYIIPLLILTSTY-GYVGFRlwnRTApgnADKGRDDMQIKSKRKVIKMLVFVVLMFGICWLPLHLFNLV 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   278 NLFVTSLDATVNHVSLILSYA-------NSCANPILYGFLSDNFR 315
Cdd:cd15391 242 QDFSTVFRNMPQHTTRLIYGAchwiamsNSFVNPIIYLFMNDSFR 286
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
55-318 3.31e-39

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 141.07  E-value: 3.31e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFViLRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAL-RHWPFGAVLCRAVLSVDGLNMFTSVFCL 133
Cdd:cd15120  12 LVGLVVNGLYLWV-LGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMdNHWAFGTVLCKVLNSTLSVGMFTSVFLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   134 TVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWS--------- 204
Cdd:cd15120  91 TAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKGKTICQNNYALSTNWEsaevqasrq 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 ---AVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALragwqqrRRSEKKITRLVLMVVTVFVlCWMPFYVVQLLNLfV 281
Cdd:cd15120 171 wihVAMFVFRFLLGFLLPFLIITFCYVRMALKMKERGL-------ARSSKPFKVMFTAVVSFFV-CWLPYHLHSGLVL-T 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   282 TSLDATVNHVSLILSYA----NSCANPILYGFLSDNFRRSF 318
Cdd:cd15120 242 RGRPPSLTDITLLLTVGttcfNTCFTPVLYLFVGENFKKVL 282
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
44-318 3.64e-39

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 141.05  E-value: 3.64e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15162   1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFkIAYHIHGNNWIFGEALCRLVTVAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVAC----NLHW 198
Cdd:cd15162  81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTChdvlPEQL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHPAWSAVFvIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSekkiTRLVLMVVTVFVLCWMPFYVVQLLN 278
Cdd:cd15162 161 LVGDWFYYF-LSLAIVGFLIPFILTASCYVATIRTLAALEDENSEKKKKRA----IKLAATVLAIFIICFAPSNLLLLAH 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   279 LFVTSLDATVN-----HVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15162 236 YSLISSSGTGHlyfayLLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
44-318 4.10e-39

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 141.27  E-value: 4.10e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRH-WPFGAVLCRAVLSV 121
Cdd:cd14997   1 VLVSVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLvCMPVALVETWAREpWLLGEFMCKLVPFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP---IAVFADTRPARGGEAVACNLHw 198
Cdd:cd14997  81 ELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPvlfITEFKEEDFNDGTPVAVCRTP- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVAL----RAGWQQRR--RSEKKITRLVLMVVTVFVLCWMPFY 272
Cdd:cd14997 160 ADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLVGHPAlesrRADAANRHtlRSRRQVVYMLITVVVLFFVCLLPFR 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 469169   273 VVQLLNLFVTS-------LDATVNHVSL--ILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14997 240 VVTLWIIFAPDedlqalgLEGYLNLLVFcrVMVYLNSALNPILYNLMSTKFRSAF 294
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
45-325 1.06e-38

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 141.45  E-value: 1.06e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     45 TIQCIYALVCLVGLVGNALVIFViLRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:PHA03087  42 ILIVVYSTIFFFGLVGNIIVIYV-LTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYI 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRpaRGGEAVACNLHWPHPA-- 202
Cdd:PHA03087 121 GFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTK--KDHETLICCMFYNNKTmn 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRavalraGWQQRRRSEKKItRLVLMVVTVFVLCWMPFYVVqllnLFVT 282
Cdd:PHA03087 199 WKLFINFEINIIGMLIPLTILLYCYSKILITLK------GINKSKKNKKAI-KLVLIIVILFVIFWLPFNVS----VFVY 267
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 469169    283 SLDATVN--------------HVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLR 325
Cdd:PHA03087 268 SLHILHFksgckavkyiqyalHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLM 324
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
49-318 1.29e-38

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 139.56  E-value: 1.29e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15921   6 AYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNsHWPFGDIACRIILYVLYVNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiavFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15921  86 SSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSP---LLFAKSKQHDEGSTRCLELAHDAVDKLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIY--TFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGwqQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV---- 281
Cdd:cd15921 163 LINyvTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALG--RTRPSRRKACALIIISLGIFLVCFLPYHIVRTIHLITerqi 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   282 ----TSLDATVNHV--SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15921 241 kescGYILRVRKAAviTLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
49-316 1.55e-38

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 139.44  E-value: 1.55e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15160   6 VYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLwIDYTANHHNWTFGPLSCKVVGFFFYTNIY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVtlPIAVFADTRPARGGEAVA-CNLHWPHPAWSAV 206
Cdd:cd15160  86 ASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGT--HSVFLGHDELFRDEPNHTlCYEKYPMEGWQAS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIVGkmravALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL--------- 277
Cdd:cd15160 164 YNYARFLVGFLIPLSLILFFYRRVLR-----AVRQSPSLEREEKRKIIGLLLSIVVIFLLCFLPYHVVLLVrsvielvqn 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   278 -------NLFVTSldatvnHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15160 239 glcgfekRVFTAY------QISLCLTSLNCVADPILYIFVTEDVRQ 278
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
50-318 3.64e-38

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 138.36  E-value: 3.64e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15154   7 YSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPA--RGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15154  87 CLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCllHGEKVYRCFESFSDNDWKGLL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 --VIYTFLLGFLLPVLAIGLCYLLIVGKMraVALRAGWQQRRRsekKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS-- 283
Cdd:cd15154 167 plVVLAEILGFLLPLAAVLYCSCRIFVEL--CRTQEPQQGRRR---KTVRLLLVNLVIFLICFVPYNTTLAVYGLLRAnl 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   284 LDATVN---------HVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15154 242 VEDTWNikdtlrkvlSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
49-317 1.61e-37

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 136.52  E-value: 1.61e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVP-FVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15194   6 LYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPlWVDKEVVLGPWRSGSFLCKGSSYIISVNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEavACNLHWPHPAwSAVF 207
Cdd:cd15194  86 CSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKE--YCNEDAGTPS-KVIF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGKmravaLRAGWQQRRRSEKKITR---LVLMVVTVFVLCWMPFYVVQLLNLF---- 280
Cdd:cd15194 163 SLVSLIVAFFLPLLSILTCYCTIIWK-----LCHHYQKSGKHQKKLRKsikIVFIVVAAFVFSWMPFNLFKALAIAsglq 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   281 --VTSLDATVNHVSLILS----YANSCANPILYGFLSDNFRRS 317
Cdd:cd15194 238 veVTCLPYTLAQLGMEVSaplaFANSCANPFIYYFFDRYIRRA 280
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
49-317 1.80e-37

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 136.49  E-value: 1.80e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15121   6 ILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVaCNLHWPHPAWSAVFV 208
Cdd:cd15121  86 SIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKL-CIPYHPSVGHEAFQY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IYTFLLGFLLPVLAIGLCYLLIVGKMRAvalragwqQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL----------- 277
Cdd:cd15121 165 LFETITGFLLPFTAIVTCYSTIGRRLRS--------ARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIqvagalqnqag 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   278 NLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15121 237 NASVLKAAKLARPNVTALAFLSSSVNPVLYAFAGGSLIRS 276
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
49-317 2.33e-37

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 136.07  E-value: 2.33e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd14975   6 LLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEavACNLHWPHPAWSAVFV 208
Cdd:cd14975  86 SVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENG--MCKYRHYSDGQLVFHL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IYTFLLGFLLPVLAIGLCYLLIVGKMRavalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT-----S 283
Cdd:cd14975 164 LLETVVGFAVPFTAVVLCYSCLLRRLR--------RRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSEliggsK 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   284 LDATVNHV-------SLILSYANSCANPILYGFLS-DNFRRS 317
Cdd:cd14975 236 MAGTLGKVaeagrpiAGALAFLSSSINPLLYAFAArGLFRSA 277
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
49-318 3.23e-37

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 135.61  E-value: 3.23e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15157   6 VYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGsHWVFGDIACRIMSYSLYVNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWlasLLVTLPIAVFADTRPARGGEAVACnLHWPHPAWSAVF 207
Cdd:cd15157  86 CSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIW---IFVMAASSPLLSKGTSKYNSQTKC-LDLHPSKIDKLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLL--GFLLPVLAIGLCYLLIVGKMraVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD 285
Cdd:cd15157 162 ILNYIVLvvGFILPFCTLSICYILIIKAL--LKPRVPQSKLRVSHKKALLTIIITLILFLLCFLPYHILRTVHLMQWSEG 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   286 ATVNHV------SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15157 240 QCNLRLhkavviTLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
44-318 4.34e-37

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 135.84  E-value: 4.34e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRyAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFG------AVLCRA 117
Cdd:cd14978   1 VLYGYVLPVICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSflsyfyAYFLPY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   118 VLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLH 197
Cdd:cd14978  80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   198 WPHPAW---SAVFVIYTFL---LGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRS--------EKKITRLVLMVVTV 263
Cdd:cd14978 160 IPTLLRqneTYLLKYYFWLyaiFVVLLPFILLLILNILLIRALRKSKKRRRLLRRRRRllsrsqrrERRTTIMLIAVVIV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   264 FVLCWMPFYVVQLLNLFVTSLD-----ATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14978 240 FLICNLPAGILNILEAIFGESFlspiyQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
50-318 8.02e-37

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 134.43  E-value: 8.02e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF---VASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd14995   7 VLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLpneIESLLGPDSWIYGYAGCLLITYLQYLGI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRP--ARGGEAVACNLHWPHPAWS 204
Cdd:cd14995  87 NASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIkhYGDDIVVRCGYKVSRHYYL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIyTFLLGFLLPVLAIGLCYLLIVGKMRAvalragwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS- 283
Cdd:cd14995 167 PIYLA-DFVLFYVIPLLLAIVLYGLIGRILFS------------SRKQVTKMLAVVVVLFALLWMPYRTLVVYNSFASPp 233
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   284 -LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14995 234 yLDLWFLLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
48-318 8.60e-37

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 134.45  E-value: 8.60e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15161   5 LFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMrLVYHLSGNHWPFGEVPCRLAGFLFYLNM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGgeAVACNLHWPHPAWSAV 206
Cdd:cd15161  85 YASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNN--TTVCLQLYREKASRGA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FViyTFLLGFLLPVLAIGLCYLLIVGKmravaLRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD- 285
Cdd:cd15161 163 LV--SLAVAFTIPFVTTVTCYLLIIRS-----LRTGKREEKPLKDKAIKMIILVLTIFLICFVPYHISRYIYILSHNGAg 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   286 ---------ATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15161 236 ascssrrglALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
48-317 1.46e-36

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 134.21  E-value: 1.46e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15156   5 CVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15156  85 GSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSETCFENFSSKTWKTYL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 ---VIYTFLLGFLLPVLAIGLCYLLIVGKM-RAVALRAGwqqrRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL------ 277
Cdd:cd15156 165 skiVIFIEIVGFFIPLILNVTCSTMVLKTLrRPNTLSRS----KLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLyslvrt 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   278 ----NLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15156 241 qtfkNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSETIQNS 284
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
49-316 1.95e-36

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 133.84  E-value: 1.95e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15183   6 LYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEavACNLHWPHPA---WSA 205
Cdd:cd15183  86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHH--TCSAHFPRKSlirWKR 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMravalragwqQRRRSEK--KITRLVLMVVTVFVLCWMPFYVVQLLNLF--- 280
Cdd:cd15183 164 FQALKLNLLGLILPLLVMIICYTGIINIL----------LRRPNEKkaKAVRLIFVITLLFFLLWTPYNLAAFVSAFqdv 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   281 --------VTSLDATVnHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15183 234 lftpsceqSQQLDLAL-QVTEVIAYTHCCVNPVIYVFVGERFRK 276
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
44-318 4.12e-36

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 132.97  E-value: 4.12e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVD 122
Cdd:cd15368   1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRnHWIFGKPLCNVVTVLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVAC--NLHW-- 198
Cdd:cd15368  81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKELNITTCfdVLKWtm 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 -PHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSekkiTRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:cd15368 161 lPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERYGREQKRRA----IYLALIVLLVFITCFAPNNFILLA 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   278 N----LFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15368 237 HmvsrLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
49-318 5.05e-36

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 132.57  E-value: 5.05e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd14991   6 LLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFrIDYYLRGEHWIFGEAWCRVNLFMLSVNRS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd14991  86 ASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSLSIRW 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGKMRavalRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD-- 285
Cdd:cd14991 166 HNALFLLEFFLPLGLIVFCSVRIACNLR----IRQSLGKQARVQRAIRLVFLVVIVFVLCFLPSIIAGLLALVFKNLGsc 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   286 ------ATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14991 242 rclnsvAQLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
48-318 6.54e-36

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 132.29  E-value: 6.54e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLV---GNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15055   2 LLYIVLSSISLLtvlGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVmPFSMIRSIETCWYFGDTFCKLHSSLDY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAV---ACNLHWPH 200
Cdd:cd15055  82 ILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYNScygECVVVVNF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWSAVFVIytfllGFLLPVLAIGLCYLLI-------VGKMRAVALRAGWQQR-----RRSEKKITRLVLMVVTVFVLCW 268
Cdd:cd15055 162 IWGVVDLVL-----TFILPCTVMIVLYMRIfvvarsqARAIRSHTAQVSLEGSskkvsKKSERKAAKTLGIVVGVFLLCW 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   269 MPFYVVQLLNLFvTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15055 237 LPYYIVSLVDPY-ISTPSSVFDVLIWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
45-318 6.57e-36

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 132.74  E-value: 6.57e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15123   2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFIQL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRaatyRRPSVAKLINLG----VWLASLLVTLPIAVFAD----TRPARGGEAVACN 195
Cdd:cd15123  82 TSVGVSVFTLTVLSADRYRAIVKPLE----LQTSDAVLKTCCkagcVWIVSMLFAIPEAVFSDlysfRDPEKNTTFEACA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   196 lhwPHPA----WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVAL------RAGWQQRRRSEKKITRLVLMVVTVFV 265
Cdd:cd15123 158 ---PYPVsekiLQEIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFnmpaeeHSHARKQIESRKRVAKTVLVLVALFA 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   266 LCWMPFYVVQLLNLFV--TSLDATVNHV-----SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15123 235 FCWLPNHILYLYRSFTyhTSVDSSAFHLiatifSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
52-318 6.83e-36

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 131.62  E-value: 6.83e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFM-LSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSV 130
Cdd:cd15210   9 VFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCaFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHP-LRAATYRRPSVAKLInLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHwpHPAWSAVFVI 209
Cdd:cd15210  89 LTLVLITLNRYILIAHPsLYPRIYTRRGLALMI-AGTWIFSFGSFLPLWLGIWGRFGLDPKVCSCSIL--RDKKGRSPKT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   210 YTFLLGFLLPVLAIGLCYLlivgkmravalragwqqrRRSEKKITRLVLMVVTVFVLCWMPFYVVqllNLFVTSLDATVN 289
Cdd:cd15210 166 FLFVFGFVLPCLVIIICYA------------------RREDRRLTRMMLVIFLCFLVCYLPITLV---NVFDDEVAPPVL 224
                       250       260       270
                ....*....|....*....|....*....|
gi 469169   290 HV-SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15210 225 HIiAYVLIWLSSCINPIIYVAMNRQYRQAY 254
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
44-315 7.44e-36

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 132.61  E-value: 7.44e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIyaLVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15928   3 VTAVCS--VLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLdLYRLWRYRPWRFGDLLCRLMYFFS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPA 202
Cdd:cd15928  81 ETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFL--LGFLLPVLAIGLCYLLIVGKM---RAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:cd15928 161 SSGLLSVMLWVstSFFFVPMVCLSLLYGLIGRALwdrRQRSRTAGASRRDNNHRQTVRMLAVIVLAFVLCWLPFHVGRVI 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   278 -------NLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15928 241 fnhsrasTKHLHYVSQYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
45-318 9.78e-36

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 131.33  E-value: 9.78e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVlPLAIIRQLLGYWPLGSHLCDFWISLDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNlhwphpaW 203
Cdd:cd15061  81 LLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSCYYT-------Y 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVgkmrAVALRagwqqrrrsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS 283
Cdd:cd15061 154 DKGYRIYSSMGSFFLPLLLMLFVYLRIF----RVIAK---------ERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCDC 220
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   284 -LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15061 221 qFSEALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
50-317 1.18e-35

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 131.80  E-value: 1.18e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15373   7 YGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLlVYYYADENDWPFSEALCKIVRFLFYTNLYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRpARGGEAVACNLhwPHPAWSAVFV 208
Cdd:cd15373  87 SILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTS-DKGGNITCHDT--SSPELFDQFV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IY---TFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGwqQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD 285
Cdd:cd15373 164 VYssvMLVLLFCVPFVVILVCYALMVRKLLKPSAGTS--TNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSFRSMD 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   286 ATVNHVSLI---------LSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15373 242 LSCGTLNAInlaykvtrpLASANSCLDPILYFLAGQSFRSN 282
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
50-316 1.26e-35

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 131.49  E-value: 1.26e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASaAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15186   7 YSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTH-YLINEWGLHNAMCKLTTAFFFIGFFGG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPargGEAVACNLHWPHPAWSAVFVI 209
Cdd:cd15186  86 IFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKE---NECLGDYPEVLQEIWPVLRNV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   210 YTFLLGFLLPVLAIGLCYLLIVgkmravalRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVV------QLLNLFVT- 282
Cdd:cd15186 163 ELNFLGFLLPLLIMSYCYFRII--------QTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMifletlKLYDFFPSc 234
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   283 ----SLDATVnHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15186 235 dmkkDLRLAL-SVTETIAFSHCCLNPLIYAFAGEKFRR 271
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
49-317 1.37e-35

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 131.41  E-value: 1.37e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15012   5 LYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVgIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSYT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15012  85 ASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLDREMFNS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIY---TFLLGFLLPVLAIGLCYLLIvgkmrAVALRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS- 283
Cdd:cd15012 165 KLYdtiNFIVWYLIPLLIMTVLYSKI-----SIVLWKSSSIEAR--RKVVRLLVAVVVSFALCNLPYHARKMWQYWSEPy 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   284 -----LDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15012 238 rcdsnWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
45-318 1.58e-35

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 131.78  E-value: 1.58e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd14977   2 VIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLlCVPLNAYNLLTKDWLFGDVMCKLVPFIQV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTR---PARGGEAVACNLHwPH 200
Cdd:cd14977  82 TSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVAresSLDNSSLTVCIMK-PS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWSAVF----VIYTFLLGFLLPVLAIGLCYLLIVGKMRAVA--LRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVV 274
Cdd:cd14977 161 TPFAETYpkarSWWLFGCYFCLPLAFTAVCYLLMARTLIRAAkeYTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLPEHIS 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 469169   275 QLLNLFV---------TSLDaTVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14977 241 NILRATLynevlidtrSTLD-ILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
48-316 1.84e-35

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 131.05  E-value: 1.84e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVAsAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15177   5 CVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAA-AETLQGWIFGNAMCKLIQGLYAINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRR--PSVAKLINLGVWLASLLVTLPIAVFadTRPARGGEAVACNLHWPHPAWSA 205
Cdd:cd15177  84 SGFLFLTCISVDRYVVIVRATSAHRLRPktLFYSVLTSLIVWLLSILFALPQLIY--SRVENRSELSSCRMIFPEVVSRT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFV---IYTFLLGFLLPVLAIGLCYLLIVgkmRAVALRAGWQQRRrsekkITRLVLMVVTVFVLCWMPFYVVQLL---NL 279
Cdd:cd15177 162 VKGataLTQVVLGFAIPLIVMAVCYAAIG---RTLLAARGWERHR-----ALRVIAALVVAFVLFQLPYSVVLLLdtaDL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   280 FVTSL----DATVNHVSLI----LSYANSCANPILYGFLSDNFRR 316
Cdd:cd15177 234 LATLElscsQSKRKDIALLvtsgLAYVRCCLNPLLYAFVGVRFRR 278
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
49-318 2.44e-35

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 130.54  E-value: 2.44e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PF-VASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15053   6 FLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVmPFaVYVEVNGGKWYLGPILCDIYIAMDVMCS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARggEAVACNLhwphpaWSAV 206
Cdd:cd15053  86 TASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYR--DPEECRF------YNPD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIVgkmraVALragwqqrrRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDA 286
Cdd:cd15053 158 FIIYSSISSFYIPCIVMLLLYYRIF-----RAL--------RREKKATKTLAIVLGVFLFCWLPFFTLNILNAICPKLQN 224
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   287 TVNHVSLI-------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15053 225 QSCHVGPAlfslttwLGYVNSFLNPIIYTIFNIEFRKAF 263
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
49-318 3.19e-35

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 131.06  E-value: 3.19e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15205   6 TYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLItFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIaVFADT-----RPARGGEAVACNLHWPHPA 202
Cdd:cd15205  86 TSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPM-LFVQQlevkyDFLYEKRHVCCLERWYSPT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMravalragWQQRR-------------------RSEKKITRLVLMVVTV 263
Cdd:cd15205 165 QQKIYTTFILVILFLLPLTTMLFLYSRIGYEL--------WIKKRvgdasvlqtihgiemskisRKKKRAVKMMVTVVLL 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 469169   264 FVLCWMPFYVVQLLNLFvTSLDATVNHVSL--------ILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15205 237 FAVCWAPFHVVHMMIEY-SNLENKYDGVTIklifaivqLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
49-316 4.27e-35

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 130.33  E-value: 4.27e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15185   6 LYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRpaRGGEAVACNLHWPHP---AWSA 205
Cdd:cd15185  86 EIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQ--ELFEEFLCSPLYPEDtedSWKR 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMravaLRAgwqqRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD 285
Cdd:cd15185 164 FHALRMNIFGLALPLLIMVICYTGIIKTL----LRC----PSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSIFF 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   286 AT----------VNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15185 236 ETdcerskhldlAMQVTEVIAYTHCCINPVIYAFVGERFRK 276
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
49-318 5.37e-35

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 130.04  E-value: 5.37e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15155   6 VYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPArgGEAVACNLHWPHPAWSAVF- 207
Cdd:cd15155  86 SMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVS--NTSTTCFEGFSKSIWKTYLs 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 --VIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAgwqQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL-------- 277
Cdd:cd15155 164 kiTIFIEVVGFIIPLLLNLTCSSLVLRTLRKPATLS---QIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLyalvrsqa 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   278 --NLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15155 241 iaNCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
49-316 6.77e-35

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 129.87  E-value: 6.77e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15158   6 LYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLrVVYYVHKGQWLFGDFLCRISSYALYVNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHP---LRAATYRRpsvAKLINLGVWLASLLVTLPIAVFADTRPArgGEAVACNLHWPHPAWS 204
Cdd:cd15158  86 CSIYFMTAMSFTRFLAIVFPvqnLNLVTVKK---ARIVCVGIWIFVTLTSSPFLMSGSHDTE--TNKTKCFEPPQSNQQL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFL---LGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQLLNL-F 280
Cdd:cd15158 161 TKLLVLNYIslvVGFIIPFLVILICYAMIIRTLLKNTMKARKQQSSR--KKAIRMIIIVLLAFLVSFMPYHIQRTIHLhF 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   281 VTSLDATVNH---------VSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15158 239 LSRKDSTCEEvlymqksvvITLCLAAANCCFDPLLYFFSGENFRR 283
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
48-315 8.35e-35

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 129.80  E-value: 8.35e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelfmLSVPFVASAA-----ALRHWPFGAVLCRAVLSVD 122
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIAD----LVVAFFTVLTqiiweATGEWVAGDVLCRIVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRpsVAKLINLGVWLASLLVTLP-IAVFADTRpaRGGEAVACNLHWPHP 201
Cdd:cd14986  81 VVGLFASTYILVSMSLDRYQAIVKPMSSLKPRK--RARLMIVVAWVLSFLFSIPqLVIFVERE--LGDGVHQCWSSFYTP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKM-------RAVALRAGWQQRR-------------RSEKKITRLVLMVV 261
Cdd:cd14986 157 WQRKVYITWLATYVFVIPLIILSYCYGRILRTIwirsrqkTDRPIAPTAMSCRsvscvssrvslisRAKIKTIKMTLVII 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   262 TVFVLCWMPFYVVQLLNLF--VTSLDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd14986 237 LAFILCWTPYFIVQLLDVYagMQQLENDAYVVSETLASLNSALNPLIYGFFSSHLS 292
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
44-315 1.38e-34

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 128.75  E-value: 1.38e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYA-KMKTATNIYLLNLAVADELFMLSVPFVASAAAlRHWPFGAVLCRAVLSVD 122
Cdd:cd15188   1 VFLPVFYTLVFLLGLAGNLLLFVVLLLYVpKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVA-WHWVFGSFLCKFVSTLY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVH--PLRAATYRRPSVakLINLGVWLASLLVTLPIAVFADTRPARGGEAVaCNLHW-- 198
Cdd:cd15188  80 TINFYSGIFFVSCMSLDKYLEIVHaqSPHRLRTRRKSL--LVLVAVWVLSIALSVPDMVFVQTHHTNNGVWV-CHADYgg 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMraVALRAGWQQRrrsekkITRLVLMVVTVFVLCWMPFYVV---- 274
Cdd:cd15188 157 HHTIWKLVFQFQQNLLGFLFPLLAMVFFYSRIACVL--TRLRPPGQGR------ALRFVAALVVVFFVLWFPYNLTlflh 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   275 QLLNLFVTSLDATVNH------VSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15188 229 SLQDLHVIGNCERSRHldyalqVTESLAFVHCCLNPLLYAFVSKRFR 275
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-318 1.56e-34

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 128.92  E-value: 1.56e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:cd15125   3 IPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVIQLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVF---ADTRPARGGEAVACnLHWP-- 199
Cdd:cd15125  83 SVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFsevAHIMPDDNTTFTAC-IPYPqt 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 ---HPAWSAVFViytFLLGFLLPVLAIGLCYLLIVGKMRAVA------LRAGWQQRRRSEKKITRLVLMVVTVFVLCWMP 270
Cdd:cd15125 162 demHPKIHSVLI---FLVYFLIPLAIISIYYYHIAKTLIKSAhnipgeYSEHSKRQMETRKRLAKIVLVFVGLFAFCWFP 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 469169   271 FYVVQLLNLF-VTSLDATVNH-----VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15125 239 NHVLYMYRSFnYNEIDSSLGHmivtlVARVLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
48-317 5.21e-34

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 127.07  E-value: 5.21e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRhWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15165   5 VVYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKKQ-WPLGRTLCSFLESLYFVNMY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADtrpaRGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15165  84 GSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHD----KPTNNTRCFHGFSNKTWSKKV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGKMRavALRAGWQQRRRSEKKItRLVLMVVTVFVLCWMPFYVVQLL-----NLFVT 282
Cdd:cd15165 160 IVVVEEFGFLIPMAVMVFCSVQIIRTLL--DMRRPEQPKVKQNKSV-KIVLSNLVVFLVCFTPYHLGIFLqflvkNDIIN 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   283 SLDATVN-----HVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15165 237 DCSTKQSirlfvQVSMCLANVNCCLDAICYYFILKEFRES 276
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
49-318 6.89e-34

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 126.91  E-value: 6.89e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-ELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15978   6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDlMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRP---ARGGEAVACNLHWPHPAWS 204
Cdd:cd15978  86 VSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPftrINNSTGNMCRLLWPNDVTQ 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLGFLLPVLAIGLCYLLIvgkmrAVALRAGWqQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT-- 282
Cdd:cd15978 166 QSWYIFLLLILFLIPGIVMMTAYGLI-----SLELYRGI-KFLMAKKRVIRMLIVIVILFFLCWTPIFSANAWRAFDTrs 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   283 ---SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15978 240 adrLLSGAPISFIHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
50-316 7.57e-34

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 126.84  E-value: 7.57e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVP-FVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15374   7 YGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPtLIYYYADHNHWPFGVVACKIVRFLFYANLYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrpARGGEAVACNlHWPHPAWSAVFV 208
Cdd:cd15374  87 SILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTT--SRKDNITLCH-DTTRPEEFDHYV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IY-TFLLGFL--LPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD 285
Cdd:cd15374 164 HYsSAVMVLLfgIPCLVIVVCYGLMARRLCKPRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVARLLK 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   286 ATVNHVSLI---------LSYANSCANPILYGFLSDNFRR 316
Cdd:cd15374 244 ADCDTLNIInvtykvtrpLASANSCLDPILYFLAGDKYRR 283
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
44-318 1.07e-33

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 126.68  E-value: 1.07e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15051   1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVlPFSAIYELRGEWPLGPVFCNIYISLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPIAVFADTRPAR---GGEAVACNLHW 198
Cdd:cd15051  81 VMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSfLPIHLGWNTPDGRvqnGDTPNQCRFEL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 phpawSAVFVIYTFLLGFLLPVLAIGLCYLLI--VGKMRA---------VALRAGWQQRRRSEKKITRLVLMVVTVFVLC 267
Cdd:cd15051 161 -----NPPYVLLVAIGTFYLPLLIMCGVYLRIfrIAREQAkrinaltpaSTANSSKSAATAREHKATVTLAAVLGAFIIC 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   268 WMPFYVV-QLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15051 236 WFPYFTYfTYRGLCGDNINETALSVVLWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
48-314 1.13e-33

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 126.46  E-value: 1.13e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVIlRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLSVDGLNM 126
Cdd:cd15118   5 CLHGIVSTLGIVENLLILWVV-GFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHtWELGTTFCRIHSSIFFLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVA-----------CN 195
Cdd:cd15118  84 FVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKDGRKLCyynfalfspspDN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   196 LHWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRavalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQ 275
Cdd:cd15118 164 NHPICKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIR--------HRCRRRPGRFVRLVVSVVVSFALCWAPYHIFS 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   276 LLNL---FVTSLDATVNH---VSLILSYANSCANPILYGFLSDNF 314
Cdd:cd15118 236 IIEVmahNQHSLRPLVIQglpFATTLAFLNSVLNPVLYVFSCPDF 280
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
52-318 1.19e-33

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 125.85  E-value: 1.19e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSV 130
Cdd:cd15329   9 IIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVmPLAIIYELSGYWPFGEILCDVWISFDVLLCTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEavACNLHwPHPawsaVFVIY 210
Cdd:cd15329  89 LNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIP-PLFGWKNKVNDPG--VCQVS-QDF----GYQIY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   211 TFLLGFLLPVLAIglcyLLIVGKMRAVAlragwqqrrRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT-----SLD 285
Cdd:cd15329 161 ATFGAFYIPLIVM----LVLYYKIYRAA---------KSERKAIKTLGIIMGAFTLCWLPFFILALLRPFLKpikcsCIP 227
                       250       260       270
                ....*....|....*....|....*....|...
gi 469169   286 ATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15329 228 LWLSRLFLWLGYANSFLNPIIYAKFNREFRTPF 260
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
49-318 2.13e-33

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 126.42  E-value: 2.13e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPF--GAVLCRAVLSVDGLNM 126
Cdd:cd15358   6 TYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLELYEMWSNYPFllGAGGCYFKTLLFETVC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP----IAVFADTRPARG--GEAVACNLHWPH 200
Cdd:cd15358  86 FASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPntslHGIFQLTVPCRGpvPDSATCMLVKPR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWSAVFVIyTFLLGFLLPVLAIGLCYLLIVGKMR---------AVALRAG-------WQQRRRSEKKITRLVLMVVTVF 264
Cdd:cd15358 166 WMYNLIIQI-TTLLFFFLPMGTISVLYLLIGLQLKrekmllvleAKGSKAGdsyqhrrIQQEKRRRRQVTKMLFVLVVVF 244
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 469169   265 VLCWMPFYVVQLLNLFVTSLDATVNHV-------SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15358 245 GICWAPFHTDRLMWSFISQWTGELHLAfqyvhiiSGVFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
51-318 3.21e-33

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 125.51  E-value: 3.21e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV--PFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15337   8 AIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgfPLKTISSFNKKWIWGKVACELYGFAGGIFGFM 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHWPHPAW-SAVF 207
Cdd:cd15337  88 SITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIP-PFFGWGRYVPEGFQTSCTFDYLSRDLnNRLF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGKMRA-------------VALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVV 274
Cdd:cd15337 167 ILGLFIFGFLCPLLIIIFCYVNIIRAVRNhekemtqtaksgmGKDTEKNDARKKAEIRIAKVAIILISLFLLSWTPYAVV 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   275 QLLNLF--VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15337 247 ALLGQFgpAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
44-318 3.44e-33

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 124.76  E-value: 3.44e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15059   1 VAISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLImPFSLVNELMGYWYFGSVWCEIWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL-PIAVFADTRPARGGEAVaCNLhwphp 201
Cdd:cd15059  81 VLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLpPLFGWKDEQPWHGAEPQ-CEL----- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIvgkmravalragWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15059 155 SDDPGYVLFSSIGSFYIPLLIMIIVYARI------------YRAAKRKERRFTLVLGVVMGAFVLCWLPFFFTYPLVVVC 222
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   282 TS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15059 223 KTcgVPELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
49-318 4.15e-33

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 125.33  E-value: 4.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPF--GAVLCRAVLSVDGLNM 126
Cdd:cd15133   6 TYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLELYELWQNYPFllGSGGCYFKTFLFETVC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGG--EAVACNLHWPHPAWS 204
Cdd:cd15133  86 LASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGvpASAQCTVRKPQAIYN 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLgFLLPVLAIGLCYLLI---VGKMRAVALRA----------GWQQRRRSEKKITRLVLMVVTVFVLCWMPF 271
Cdd:cd15133 166 MIPQHTGHLF-FVLPMAVISVLYLLMalrLARERGLDATGagskigtrtgQLLQHPRTRAQVTKMLFILVVVFAICWAPF 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 469169   272 YVVQLLNLFVT----SLDATVNHV---SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15133 245 HIDRLMWSFISdwtdNLHEVFQYVhiiSGVFFYLSSAVNPILYNLMSTRFREMF 298
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
51-317 6.15e-33

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 124.75  E-value: 6.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFM-LSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15083   8 LIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCiLNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHWPHPAWSA-VFV 208
Cdd:cd15083  88 INTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP-PLFGWSRYVLEGLLTSCSFDYLSRDDANrSYV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IYTFLLGFLLPVLAIGLCYLLIV-------------GKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQ 275
Cdd:cd15083 167 ICLLIFGFVLPLLIIIYCYSFIFravrrhekamkemAKRFSKSELSSPKARRQAEVKTAKIALLLVLLFCLAWTPYAVVA 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   276 LLNLF--VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15083 247 LIGQFgyLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
51-318 6.28e-33

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 123.96  E-value: 6.28e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH--WPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15052   8 LLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSILTELFGgvWPLPLVLCLLWVTLDVLFCTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHpawsavFV 208
Cdd:cd15052  88 SIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDTTNVLNNGTCVLFNPN------FV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IYTFLLGFLLPVLAIGLCYLLIVGKMRAvalragwqqrrrsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATV 288
Cdd:cd15052 162 IYGSIVAFFIPLLIMVVTYALTIRLLSN-------------EQKASKVLGIVFAVFVICWCPFFITNILTGLCEECNCRI 228
                       250       260       270
                ....*....|....*....|....*....|....
gi 469169   289 NH----VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15052 229 SPwllsVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
49-318 9.40e-33

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 123.72  E-value: 9.40e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAaLRH--WPFGAVLCRAVLSVDGLNM 126
Cdd:cd15367   6 VYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYV-LQHdnWTYSELLCKICGILLYENI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTlpIAVFADTRPARGGEA-VACNLHWPHPAWSA 205
Cdd:cd15367  85 YISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTC--VFFFLHGEISKDKENhSVCFEHYPIKAWEH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIvgkMRAVALRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQLL-NLFVTSL 284
Cdd:cd15367 163 NINYYRFYAGFLFPIFLLSFSYCRI---LRAVRKSHGTQKSQK--IQIKRLVLSTVVIFLVCFGPYHILLLVrSVFERDC 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   285 DAT-----VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15367 238 NFAegifnYYHFSLLLTSFNCVADPVLYCFASESTYHDF 276
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
46-315 9.79e-33

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 127.05  E-value: 9.79e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     46 IQCIYALVCLVGLVGNALVIfVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAaLRHWPFGAVLCRAVLSVDGLN 125
Cdd:PHA02638 101 IKIFYIIIFILGLFGNAAII-MILFCKKIKTITDIYIFNLAISDLIFVIDFPFIIYNE-FDQWIFGDFMCKVISASYYIG 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPI--------AVFADTRPARGGEAVACNLH 197
Cdd:PHA02638 179 FFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAyfifeasnIIFSAQDSNETISNYQCTLI 258
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    198 WPHPAWSAVFV--IYTF---LLGFLLPVLAIGLCYLLIVGKMRavalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFY 272
Cdd:PHA02638 259 EDNEKNNISFLgrILQFeinILGMFIPIIIFAFCYIKIILKLK--------QLKKSKKTKSIIIVSIIIICSLICWIPLN 330
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 469169    273 VVQLLNLFVT--SLDATVN-HV--------SLILSYANS----CANPILYGFLSDNFR 315
Cdd:PHA02638 331 IVILFATMYSfkGFNSIISeHIcgfiklgyAMMLAEAISlthcCINPLIYTLIGENFR 388
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
49-318 1.19e-32

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 123.65  E-value: 1.19e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15375   6 MYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGeSWIFGEFMCKFIRFIFHFNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARggEAVAC----NLHWPHPAW 203
Cdd:cd15375  86 GSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKN--NRTICldftSSDNLNTIW 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 saVFVIYTFLLGFLLPVLAIGLCYLLIVgkmraVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV-- 281
Cdd:cd15375 164 --WYNWILTVLGFLLPLVIVTLCYTRII-----YTLAKGPHTGSASKQKARRLIILILLVFYVCFLPFHILRVVRIETrl 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   282 ----TSLDATVNHVSLI---LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15375 237 ppvsCCLKHQVHAIYIItrpLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
49-315 1.21e-32

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 123.70  E-value: 1.21e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALrHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15176   6 FYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVN-GWVLGTAMCKITSALYTMNFSC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVvhplrAATYRRPSVAK---LINLGVWLASLLVTLPIAVFADTRpaRGGEAVACNLHWPHP---A 202
Cdd:cd15176  85 GMQFLACISVDRYVAI-----TKATSRQFTGKhcwIVCLCVWLLAILLSIPDLVFSTVR--ENSDRYRCLPVFPPSlvtS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYllivGKMRAVALRAGWQQRRRSekkiTRLVLMVVTVFVLCWMPFYVVQL------ 276
Cdd:cd15176 158 AKATIQILEVLLGFVLPFLVMVFCY----SRVARALSRTPNVKKSRA----LKVLLAVVGVFIVTQLPYNVVKFyraidv 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   277 LNLFVTSLDAT-----VNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15176 230 IYLLITDCSMSktldiAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
49-316 1.61e-32

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 123.48  E-value: 1.61e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15377   6 VYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKtDWIFGDAMCKLQRFIFHVNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15377  86 GSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGT-GVRKNKTITCYDTTSDEYLRSYF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 V--IYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL-----F 280
Cdd:cd15377 165 IysMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNAPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLrarldF 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 469169   281 VTSLDATVN-------HVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15377 245 QTPAMCAFNdrvyatyQVTRGLASLNSCVDPILYFLAGDTFRR 287
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
44-318 2.82e-32

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 122.33  E-value: 2.82e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15327   1 VGVGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVlPFSATLEVLGFWAFGRVFCDIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL-PIAVFADTRPArggEAVACNLhwphp 201
Cdd:cd15327  81 VLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIgPLLGWKEPPPP---DESICSI----- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLlivgKMRAVALRAGwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15327 153 TEEPGYALFSSLFSFYLPLMVILVMYF----RVYVVALKFS------REKKAAKTLAIVVGVFILCWFPFFFVLPLGSFF 222
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   282 TSLDAT--VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15327 223 PALKPSemVFKVIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
50-316 3.30e-32

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 122.56  E-value: 3.30e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd16001   7 YSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRdRWPFGDFLCKLVRFLFYTNLYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrPARGGEAVACNLHWPHpAWSAVFV 208
Cdd:cd16001  87 SILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYART-GSINNRTVCYDLTSPD-NFGNYFP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IYTFL--LGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSekKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDA 286
Cdd:cd16001 165 YGMVLtvTGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKAARA--KSIRTILLVCGLFALCFVPFHITRTIYLFVRVYLV 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   287 TVNHV--SLILSYA--------NSCANPILYgFLSDNFRR 316
Cdd:cd16001 243 QDCPLlqFVSLAYKiwrplvsfNSCINPLLY-FLSGDSNR 281
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
52-318 4.82e-32

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 122.08  E-value: 4.82e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASA-AALRHWPFGAVLCRAVLSVDGLNMFTSV 130
Cdd:cd15201   9 LEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYyLRGKHWKFGDIPCRIVLFMLAMNRAGSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLasLLVTLPIAVFADTRPARGGEAVACN--LHWPHPAWSAVFV 208
Cdd:cd15201  89 FFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWL--LTIAMTVYLLTKKHLFPRGNATQCEsfNICTGTDSSSNWH 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IYTFLLGFLLPVLAIGLCYLLIVGKMRAVALragwqQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDA-- 286
Cdd:cd15201 167 EAMFLLEFFLPLAIILYCSVRIIWQLRGRQL-----DRHAKIKRAVQFIMVVAIVFIICFLPSNVTRIAIWILKHTSNed 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   287 --------TVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15201 242 cqyyrsvdLAFYITISFTYFNSMLDPVVYYFSSPSFKNFY 281
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
50-316 6.18e-32

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 121.81  E-value: 6.18e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15968   7 YSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLlIYNYAMRDRWLFGDFMCRLVRFLFYFNLYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEaVACNLHWPHPAWSAV-F 207
Cdd:cd15968  87 SILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRT-VCYDLAPPALFPHYVpY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGKM-RAVALRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDA 286
Cdd:cd15968 166 GMALTVSGFLLPFSIILWCYCLVVRTLcRTLGPAEPPAQARR--RKSIRTIVTVTLLFALCFLPFHITRTIYLAVRVTPG 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   287 TVNH----------VSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15968 244 VPCHvleavaacykITRPLASANSVLNPLLYFLTKKKFGR 283
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-318 7.08e-32

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 121.89  E-value: 7.08e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWP--FGAVLCRAVLSVDGLNM 126
Cdd:cd15357   6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEVYEMWSNYPflFGPVGCYFKTALFETVC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP--------IAVFADTRPARGGEAVACnlhw 198
Cdd:cd15357  86 FASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPntsihgikLQYFPNGTLIPDSATCTV---- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHPAWSAVFVI-YTFLLGFLLPVLAIGLCYLLIVGKMRA----VALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYV 273
Cdd:cd15357 162 VKPLWIYNLIIqITSLLFYVLPMGVISVLYYLMGLKLRGdkslEADEMNVNIQRPSRKSVTKMLFVLVLVFAICWAPFHV 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   274 VQLLNLFVT----SLDATVN--HV-SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15357 242 DRLFFSFVVewtePLANVFNliHVvSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
49-318 7.19e-32

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 121.06  E-value: 7.19e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15063   6 VLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPAR-GGEAVACNLHWP-HPAWSA 205
Cdd:cd15063  86 ASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGiMDYSGSSSLPCTcELTNGR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIvgkmravaLRAGwqqrrRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS-L 284
Cdd:cd15063 166 GYVIYSALGSFYIPMLVMLFFYFRI--------YRAA-----RMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAFCEDcI 232
                       250       260       270
                ....*....|....*....|....*....|....
gi 469169   285 DATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15063 233 PPLLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
50-318 7.44e-32

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 121.92  E-value: 7.44e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15980   7 YLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVgIFCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATyrRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVA-----------CNLH 197
Cdd:cd15980  87 SVFTLVAIAVDRFRCIVYPFKQKL--TISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLgsqnktspvywCRED 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   198 WPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAG-------WQQRRRSEKKITRLVLMVVTVFVLCWMP 270
Cdd:cd15980 165 WPNQEMRKIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTgkhnqeqRHVVSRKKQKVIKMLLIVALLFILSWLP 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 469169   271 FYVVQLLNLFVtslDATVNHVSLI----------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15980 245 LWTLMMLSDYA---NLSPNQLQIIniyiypfahwLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
44-318 7.44e-32

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 122.15  E-value: 7.44e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMK-TATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAvLCRAVLSV 121
Cdd:cd15057   1 IITGCILYLLVLLTLLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAILVmPWAAVNEVAGYWPFGS-FCDVWVSF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPI------AVFADTRPARGGEAVAC 194
Cdd:cd15057  80 DIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISfIPVqlgwhrADDTSEALALYADPCQC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   195 NLhwphpAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRR---------------RSEKKITRLVLM 259
Cdd:cd15057 160 DS-----SLNRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIRRIAALERAaqestnpdsslrsslRRETKALKTLSI 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   260 VVTVFVLCWMPFYVVQLLNLF-------VTSLDATVNHVSLILSYANSCANPILYGFLSDnFRRSF 318
Cdd:cd15057 235 IMGVFVCCWLPFFILNCVLPFcdlrtaqFPCVPDTTFIVFVWLGWANSSLNPIIYAFNAD-FRKAF 299
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
48-318 1.06e-31

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 121.35  E-value: 1.06e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15195   5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVtFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInlGVWLASLLVTLPIAVF--ADTRPARGGEAVACNLHW--PHPA 202
Cdd:cd15195  85 YLSSFMLVVIALDRVFAILSPLSANQARKRVKIMLT--VAWVLSALCSIPQSFIfsVLRKMPEQPGFHQCVDFGsaPTKK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRA----GWQQRR-------RSEKKITRLVLMVVTVFVLCWMPF 271
Cdd:cd15195 163 QERLYYFFTMILSFVIPLIITVTCYLLILFEISKMAKRArdtpISNRRRsrtnsleRARMRTLRMTALIVLTFIVCWGPY 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 469169   272 YVVQLLNLF----VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15195 243 YVLGLWYWFdkesIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
50-315 2.08e-31

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 120.46  E-value: 2.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelFMLSV---PFVASAAALRHWPFGAVLCRavlsVDGLNM 126
Cdd:cd15074   7 LTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSD--LGISVfgyPLAIISAFAHRWLFGDIGCV----FYGFCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 F----TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInLGVWLASLLVTL-PIAVFADTRPARGGeaVACNLHWPHP 201
Cdd:cd15074  81 FlfgcCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVI-VAIWLYALFWAVaPLVGWGSYGPEPFG--TSCSIDWTGA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSA---VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRS-----EKKITRLVLMVVTVFVLCWMPFYV 273
Cdd:cd15074 158 SASVggmSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKrqhkiERKVTKVAVLICAGFLIAWTPYAV 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   274 VQLLNLF--VTSLDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15074 238 VSMWSAFgsPDSVPILASILPALFAKSSCMYNPIIYLLFSSKFR 281
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
44-315 2.41e-31

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 120.37  E-value: 2.41e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCiyALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15131   3 ITVTC--VLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLdLYRLWQYRPWNFGDLLCKLFQFVS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFA-----------DTRPARGGE- 190
Cdd:cd15131  81 ESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVgvehengtnpiDTNECKATEy 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   191 AVACNLHWPHPAWSAVFviytfllgFLLPVLAIGLCYLLIVGKM---RAVALRAGWQQRRRSEKKITRLVLMVVTVFVLC 267
Cdd:cd15131 161 AVRSGLLTIMVWVSSVF--------FFLPVFCLTVLYSLIGRKLwrrRRENIGPNASHRDKNNRQTVKMLAVVVFAFVLC 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   268 WMPFYVVQLL--------NLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15131 233 WLPFHVGRYLfsksfeagSLEIALISQYCNLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
49-318 3.89e-31

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 119.53  E-value: 3.89e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15979   6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLaVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGE---AVACNLHWPHPAWS 204
Cdd:cd15979  86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDrprGHQCRHAWPSAQVR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALragwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF---- 280
Cdd:cd15979 166 QAWYVLLLLILFFIPGVVMIVAYGLISRELYRGLL---------AKKRVIRMLVVIVAMFFLCWLPIFSANTWRAFdpls 236
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   281 -VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15979 237 aHRALSGAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 4.28e-31

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 119.65  E-value: 4.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD---ELFMLSVPFVasAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd16003   7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDasmAAFNTLINFI--YALHSEWYFGEAYCRFHNFFPITSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATyrRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGgeAVACNLHWPH-PAWSA 205
Cdd:cd16003  85 FASIYSMTAIAVDRYMAIIDPLKPRL--SATATKVVIGSIWILAFLLAFPQCLYSKTKVMPG--RTLCFVAWPGgPDQHF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYlLIVGkmraVALRAG---------WQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL 276
Cdd:cd16003 161 TYHIIVIVLVYCLPLLVMGITY-TIVG----ITLWGGeipgdtsdkYHEQLRAKRKVVKMMIIVVLTFAICWLPYHIYFI 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   277 LNLFVTSLD-----ATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd16003 236 VTGLYQQLNrwkyiQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
44-318 5.30e-31

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 118.84  E-value: 5.30e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15325   1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVlPFSAIFEILGYWAFGRVFCNIWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHWPHpa 202
Cdd:cd15325  81 VLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIG-PLFGWKEPAPEDETICQITEEPG-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 wsavFVIYTFLLGFLLPVLAIglcyLLIVGKMRAVALRAGwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd15325 158 ----YALFSALGSFYLPLAII----LVMYCRVYVVALKFS------REKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIFP 223
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   283 SLDA--TVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15325 224 AYKPsdTVFKITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
46-318 7.80e-31

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 118.49  E-value: 7.80e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:cd15321   9 IAAAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVaTLIIPFSLANELMGYWYFRKTWCEIYLALDVL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHwpHPAWs 204
Cdd:cd15321  89 FCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLN--EEAW- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 avFVIYTFLLGFLLPVLAIGLCYLLIvgkmravalragWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSL 284
Cdd:cd15321 166 --YILSSSIGSFFAPCLIMILVYLRI------------YLIAKNREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPEL 231
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   285 DATVNHV---SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15321 232 CKVPHSLfqfFFWIGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
50-316 1.32e-30

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 118.30  E-value: 1.32e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15397   7 YSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVcLVCLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPlraaTYRRPSV--AKLINLGVWLASLLVTLPIAVFA--DTRPARG--------GEAVACNL 196
Cdd:cd15397  87 SILSLVLIALERHQLIINP----TGWKPSVsqAYLAVVVIWMLACFISLPFLAFHilTDEPYKNlshffaplADKAVCTE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   197 HWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMR----AVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPfy 272
Cdd:cd15397 163 SWPSEHHKLAYTTWLLLFQYCLPLLFILVCYLRIYLRLRrrkdMLERRGEYNRRAGHSKRINVMLVSLVAAFALCWLP-- 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 469169   273 vvqlLNLFVTSLD-----ATVNHVSLILS------YANSCANPILYGFLSDNFRR 316
Cdd:cd15397 241 ----LNVFNAIADwnheaIPHCQHNLIFSlchlaaMASTCVNPIIYGFLNSNFKK 291
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 1.62e-30

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 118.04  E-value: 1.62e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD---ELFMLSVPFVasAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd16002   7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEasmSAFNTVINFT--YAIHNEWYYGLEYCKFHNFFPIAAV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAatyRRPSVAKLINLGV-WLASLLVTLPIAVFADTRPARGGeaVACNLHWPHPA--- 202
Cdd:cd16002  85 FASIYSMTAIALDRYMAIIHPLQP---RLSATATKVVICViWVLAFLLAFPQGYYSDTEEMPGR--VVCYVEWPEHEerk 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALrAGWQQRRRSE-----KKITRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:cd16002 160 YETVYHVCVTVLIYFLPLLVIGCAYTVVGITLWASEI-PGDSSDRYHEqvsakRKVVKMMIVVVCTFAICWLPYHIYFLL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   278 -----NLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd16002 239 qyfhpELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-318 1.63e-30

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 118.30  E-value: 1.63e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLVGLV-GNALVIFVILRYAKMKTATNIYLLNLAVADelfmLSVPFVASAAALRH-----WPFGAVLCRAV 118
Cdd:cd15197   1 TEQLATLWVLFVFIVvGNSSVLFALWMRKAKKSRMNFFITQLAIAD----LCVGLINVLTDIIWritveWRAGDFACKVI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   119 LSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPsvAKLINLGVWLASLLVTLPIAVFADTRPARGGEaVACNLHW 198
Cdd:cd15197  77 RYLQVVVTYASTYVLVALSIDRYDAICHPMNFSQSGRQ--ARVLICVAWILSALFSIPMLIIFEKTGLSNGE-VQCWILW 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHP-AWSAVFVIYTFLLgFLLPVLAIGLCYLLIV------GKMRAVALRAGWQQRR-----------RSEKKITRLVLMV 260
Cdd:cd15197 154 PEPwYWKVYMTIVAFLV-FFIPATIISICYIIIVrtiwkkSKIQVTINKAGLHDGSsrrsssrgiipRAKIKTIKMTFVI 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 469169   261 VTVFVLCWMPFYVVQLLNLF-VTSLDATVNHVSLI---LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15197 233 VTVFIICWSPYFVFDLLDVFgLLPRSKTKIAAATFiqsLAPLNSAINPLIYCLFSTHLCRPL 294
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
45-315 3.34e-30

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 116.79  E-value: 3.34e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLV-GLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAlRHWPFGAVLCRAVLSVDG 123
Cdd:cd15923   1 LLQYAIYIPTFVlGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYR-RESAGLQKLCNFVLSLYY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRparggEAVACnLHWPHPAW 203
Cdd:cd15923  80 INMYVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLDSSN-----EKTMC-FQRTKQTE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVgkmRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV-T 282
Cdd:cd15923 154 SLKVFLLLEIFGFLLPLIIMTFCSARVI---HTLQKRLDDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVgK 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   283 SLDATVN-------HVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15923 231 SYSCDSKliihfflQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
48-308 4.34e-30

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 116.91  E-value: 4.34e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15079   5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAA--TYRRpsvAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSA 205
Cdd:cd15079  85 GSIWTNAAIAYDRYNVIVKPLNGNplTRGK---ALLLILFIWLYALPWALLPLLFGWGRYVPEGFLTSCSFDYLTRDWNT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 -VFVIYTFLLGFLLPVLAIGLCYLLIVG--------------KMRAVALRAGWQQRRRS-EKKITRLVLMVVTVFVLCWM 269
Cdd:cd15079 162 rSFVATIFVFAYVIPLIIIIYCYSFIVKavfahekalreqakKMNVVSLRSNADANKQSaEIRIAKVALTNVFLWFIAWT 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   270 PFYVVQLLNLF---------VTSLDAtvnhvslILSYANSCANPILYG 308
Cdd:cd15079 242 PYAVVALIGAFgnqslltplVSMIPA-------LFAKTAACYNPIVYA 282
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
55-318 4.46e-30

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 116.15  E-value: 4.46e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCL 133
Cdd:cd15326  12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVlPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   134 TVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHWPhpawsaVFVIYTFL 213
Cdd:cd15326  92 CAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIG-PLLGWKEPAPPDDKVCEITEEP------FYALFSSL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   214 LGFLLPVLAIglcyLLIVGKMRAVALRAGwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD--ATVNHV 291
Cdd:cd15326 165 GSFYIPLIVI----LVMYCRVYIVALKFS------REKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSHLKppETLFKI 234
                       250       260
                ....*....|....*....|....*..
gi 469169   292 SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15326 235 IFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
49-318 1.10e-29

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 116.40  E-value: 1.10e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADeLFM--LSVPFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15058   6 LLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACAD-LVMglLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPIavFADTRPARGGEAVACnlhWPHPAWSA 205
Cdd:cd15058  85 TASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSfVPI--MNQWWRANDPEANDC---YQDPTCCD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 -----VFVIYTFLLGFLLPVLAIGLCYLLI-------VGKMRAVALR----------AGWQQRRRSEKKITRLVLM---- 259
Cdd:cd15058 160 frtnmAYAIASSVVSFYIPLLIMIFVYARVfliatrqLQLIDKRRLRfqsecpapqtTSPEGKRSSGRRPSRLTVVkehk 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 469169   260 -------VVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSL-ILSYANSCANPILYgFLSDNFRRSF 318
Cdd:cd15058 240 alktlgiIMGTFTLCWLPFFIANIINVFNRNLPPGEVFLLLnWLGYINSGLNPIIY-CRSPEFRTAF 305
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
44-318 1.32e-29

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 114.83  E-value: 1.32e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15050   1 APLGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLESKWILGRPVCLFWLSMD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIA---VFADTRPaRGGEAVACNLHWP 199
Cdd:cd15050  81 YVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILgwhHFARGGE-RVVLEDKCETDFH 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWsavFVIYTFLLGFLLPVLAIGLCYLLIvgkMRAValragwqqrrRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd15050 160 DVTW---FKVLTAILNFYIPSLLMLWFYAKI---FKAV----------NRERKAAKQLGFIMAAFILCWIPYFILFMVIA 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   280 FV-TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15050 224 FCkNCCNENLHMFTIWLGYINSTLNPFIYPLCNENFKKTF 263
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
49-323 1.36e-29

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 116.54  E-value: 1.36e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     49 IYALVCLVGLVGNALVIFVILRYAKMKTaTNIYLLNLAVADELFMLSVPFVASAAaLRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:PHA02834  34 FYILLFIFGLIGNVLVIAVLIVKRFMFV-VDVYLFNIAMSDLMLVFSFPFIIHND-LNEWIFGEFMCKLVLGVYFVGFFS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    129 SVFCLTVLSVDRYVAVVHPLRAATyRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFV 208
Cdd:PHA02834 112 NMFFVTLISIDRYILVVNATKIKN-KSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWSAFFN 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    209 IYTFLLGFLLPVLAIGLCYLLIVGKMRAValragwqqRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATV 288
Cdd:PHA02834 191 FEINIFGIVIPLIILIYCYSKILYTLKNC--------KNKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLQSVGLIDI 262
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 469169    289 N-----------HVSLILSYANSCANPILYGFLSDNFRRSFQRVLC 323
Cdd:PHA02834 263 GcyhfkkivysiDIAELISFVHCCVNPIIYAFVGKNFKKVFKNMFC 308
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
44-318 1.39e-29

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 115.77  E-value: 1.39e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15124   1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEA----VACnLHW 198
Cdd:cd15124  81 LTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDKSTnktfVSC-APY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHPA--WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVAL------RAGWQQRRRSEKKITRLVLMVVTVFVLCWMP 270
Cdd:cd15124 160 PHSNelHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAYnlpvegNVHVRRQIESRKRLAKTVLVFVGLFAFCWLP 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 469169   271 FYVVQLLNLFVTS-LDATVNH-----VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15124 240 NHIIYLYRSYHYSeVDTSMLHfvssiCARILAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
49-318 1.66e-29

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 114.84  E-value: 1.66e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15060   6 LLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVlPLNVAYFLLGKWLFGIHLCQMWLTCDILCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHpawsaVF 207
Cdd:cd15060  86 ASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWPENFTETTPCTLTEEK-----GY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIvgkMRAVAlragwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDAT 287
Cdd:cd15060 161 VIYSSSGSFFIPLLIMTIVYVKI---FIATS----------KERRAARTLGIIMGVFVVCWLPFFLMYVILPFCETCSPS 227
                       250       260       270
                ....*....|....*....|....*....|...
gi 469169   288 VNHVSLI--LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15060 228 AKVVNFItwLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
46-315 1.74e-29

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 114.92  E-value: 1.74e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCL-VGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFgAVLCRAVLSVDGL 124
Cdd:cd14989   2 LSCLYTIFLFpIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNLNEKYYDI-AVLCTFMSLFLQI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLpiAVFADTRPARGGEAVACNLHWPHPAWS 204
Cdd:cd14989  81 NMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATL--LPFTAVQAQHTGEVHFCFADVREIQWL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVfviytfLLGFLLPVLAIGLCYLLIVGK-MRAVALRAGWQQRRRSekkiTRLVLMVVTVFVLCWMP---FYVVQLLNLF 280
Cdd:cd14989 159 EV------TLGFIIPFSIIGLCYSLIVRVlVRAQKHRRLRPRRQKA----LRMILVVVLVFFICWLPenvFISIQLLQGT 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   281 VTSLDAT----------VNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd14989 229 QEPSESYdesfrhnhplTGHIVNLAAFSNSCLNPLIYSFLGETFR 273
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
48-318 2.25e-29

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 115.16  E-value: 2.25e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILR-YAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLN 125
Cdd:cd15383   5 AVTFVLFVLSACSNLAVLWSATRnRRRKLSHVRILILHLAAADLLVTFVVmPLDAAWNVTVQWYAGDLACRLLMFLKLFA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSvaKLINLGVWLASLLVTLPIAVFADTRPARGGEA-VACNLHWPHPA-W 203
Cdd:cd15383  85 MYSSAFVTVVISLDRHAAILNPLAIGSARRRN--RIMLCAAWGLSALLALPQLFLFHTVTATPPVNfTQCATHGSFPAhW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 -SAVFVIYTFLLGFLLPVLAIGLCYLLIV----GKMRAVALRAGWQ-QRRRSEKKITR-------LVLMVVTVFVLCWMP 270
Cdd:cd15383 163 qETLYNMFTFFCLFLLPLLIMIFCYTRILleisRRMKEKKDSAKNEvALRSSSDNIPKarmrtlkMTIVIVSSFIVCWTP 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 469169   271 FYVVQLLNLF-----VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15383 243 YYLLGLWYWFspemlEQTVPESLSHILFLFGLLNACLDPLIYGLFTISFRRGL 295
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
51-316 2.33e-29

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 114.25  E-value: 2.33e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSV-PFVASAAALRhwpF--GAVLCRAVLSVDGLNM 126
Cdd:cd15196   8 ATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVaLFNVlPQLIWDITYR---FygGDLLCRLVKYLQVVGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInLGVWLASLLVTLP-IAVFADTRPARGGeavacNLHWPH--PAW 203
Cdd:cd15196  85 YASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMV-AIAWVLSLLLSIPqLFIFSYQEVGSGV-----YDCWATfePPW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SA-VFVIYTFLLGFLLPVLAIGLCYLLIVgkmravalRAGWqqrrRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF-- 280
Cdd:cd15196 159 GLrAYITWFTVAVFVVPLIILAFCYGRIC--------YVVW----RAKIKTVKLTLVVVACYIVCWTPFFVVQMWAAWdp 226
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   281 VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15196 227 TAPIEGPAFVIIMLLASLNSCTNPWIYLAFSGNLRR 262
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
46-318 2.57e-29

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 114.81  E-value: 2.57e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAL-RHWPFGAVLCRAVLSVDGL 124
Cdd:cd15922   3 IPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSLgSHWPFGQFLCQLKVFLLST 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiaVFADTRPARGGEAVAC-NLHwpHPAW 203
Cdd:cd15922  83 HMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLP--FFFVLKTSVIDGKTKClSIH--QSEL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLL---GFLLPVLAIGLCYLLI---VGKMRAVALRaGWQQRRRSEKKITrlvlMVVTVFVLCWMPFYVVQ-- 275
Cdd:cd15922 159 SLLYFVWNFVLlilGFLLPFGVSLTCYALLgasIAKMNSNNAR-GRAMKAKSLQMIG----ISLVIFIICFVPLHVTRtv 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 469169   276 ------LLNLFVTSLDATVN--HVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15922 234 gvvvklFYPESCTLLHKVEVayYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
44-318 4.69e-29

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 113.35  E-value: 4.69e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15062   1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVlPFSATLEVLGYWAFGRIFCDVWAAVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL-PIAVFADTRPArggEAVACNLHwphp 201
Cdd:cd15062  81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIgPLLGWKEPAPA---DEQACGVN---- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 aWSAVFVIYTFLLGFLLPVLAIglcyLLIVGKMRAVALRAgwqqrrRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15062 154 -EEPGYVLFSSLGSFYLPLAII----LVMYCRVYVVAFKF------SREKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLF 222
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   282 TSLD--ATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15062 223 STLKppEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
49-315 7.51e-29

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 113.64  E-value: 7.51e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIF-VILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15376   6 ILGVEFLVAVLGNGLALWlFVTRERRPWHTGVVFSFNLAVSDLLYALSLPLlAAYYYPPKNWRFGEAACKLERFLFTCNL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGeAVACnLHWPHPAWSAV 206
Cdd:cd15376  86 YGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLEVERHN-KTEC-LGTAVDSRLPT 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYT-FLLGF--LLPVLAIGLCYLLIVgkmRAValRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS 283
Cdd:cd15376 164 YLPYSlFLAVVgcGLPFLLTLASYLAIV---WAV--LRSPGITTLEKRKVAALVAVVVALYAVSFVPYHILRNLNLYRRL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   284 LDATVNH---------VSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15376 239 QWLKAAAslriyfayqVTKGLVTLNMCIHPLLYMAVADSIR 279
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
49-318 9.06e-29

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 112.94  E-value: 9.06e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLSVDGLNMF 127
Cdd:cd14988   6 LYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYtWLWGSFLCKFTHYFYFANMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd14988  86 SSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDGVEPMCLFLAPFETYDEWALAV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGKMRavalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQ-LLNLFVTSLDA 286
Cdd:cd14988 166 SLLTLIIGFLIPFSIIAVFNVLTARYIR--------TAGRPESRRHCLLIYAYILVFVVCWLPYHVTLlLLTLHGSHISL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   287 TVNHVSLI---------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14988 238 HCNLVHFLyffydvidcFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
51-318 1.29e-28

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 112.45  E-value: 1.29e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRH-WPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15067   7 SLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVmPFSILHEMTGGyWLFGRDWCDVWHSFDVLASTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFadTRPARGGEAVACNLHWPHpawSAVFV 208
Cdd:cd15067  87 SILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAW--WRAVDPGPSPPNQCLFTD---DSGYL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IYTFLLGFLLPVLAIGLCYLLIvgkMRAVAlragwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSldATV 288
Cdd:cd15067 162 IFSSCVSFYIPLVVMLFTYYRI---YRAAA----------KEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPS--NCV 226
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   289 NHVSLI------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15067 227 SNPDILfplvtwLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
51-318 1.62e-28

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 112.04  E-value: 1.62e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15064   8 SLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVmPLSAVYELTGRWILGQVLCDIWISLDVTCCTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVaCNLHWPHpawsaVFVI 209
Cdd:cd15064  88 ILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLP-PLFGWRTPDSEDPSE-CLISQDI-----GYTI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   210 YTFLLGFLLPvlaigLCYLLIV-GKMRAVALRagwqqrrrsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD--A 286
Cdd:cd15064 161 FSTFGAFYIP-----LLLMLILyWKIYRAAAR---------ERKAAKTLGIILGAFIVCWLPFFLVALIVPLCSHCWipL 226
                       250       260       270
                ....*....|....*....|....*....|..
gi 469169   287 TVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15064 227 ALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
45-317 1.99e-28

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 112.50  E-value: 1.99e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelFMLSV---PFVASAAALRHWPFGAVLCRAVLSV 121
Cdd:cd15336   2 TVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSD--FLMSLtqsPIFFVNSLHKRWIFGEKGCELYAFC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNlhWPHP 201
Cdd:cd15336  80 GALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLP-PLFGWSAYVPEGLLTSCT--WDYM 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLG---FLLPVLAIGLCYLLI----------VGKMRAVALR--AGWQQRRRSEKKITRLVLMVVTVFVL 266
Cdd:cd15336 157 TFTPSVRAYTMLLFcfvFFIPLGIIIYCYLFIflairstgreVQKLGSQDRKekAKQYQRMKNEWKMAKIAFVVILLFVL 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 469169   267 CWMPFYVVQLLNL--FVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15336 237 SWSPYACVALIAWagYAHLLTPYMKSVPAVIAKASAIYNPIIYAITHPKYREA 289
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
44-315 3.06e-28

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 111.30  E-value: 3.06e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15213   1 ITLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLsLVCMPFAAVTIITGRWIFGDIFCRISAMLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRpsvAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHWPHPA 202
Cdd:cd15213  81 WFFVLEGVAILLIISVDRYLIIVQRQDKLNPHR---AKILIAVSWVLSFCVSFP-PLVGWGKYEFPPRAPQCVLGYTESP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAgwqqrrrsekKITRLVLMVvtVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd15213 157 ADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSFKTRA----------FTTILILFI--GFSVCWLPYTVYSLLSVFSR 224
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   283 SLD--ATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15213 225 YSSsfYVISTCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-315 3.91e-28

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 111.81  E-value: 3.91e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIyaLVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15132   3 VTIVCL--ILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFdLYRLWKSRPWIFGEFLCRLYHYIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP----IAVFADTRPARGGEAVACNlHW 198
Cdd:cd15132  81 EGCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPflflVGVEQDNNIHPDDFSRECK-HT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHPAWSAVF--VIYTFLLGFLLPVLAIGLCYLLI---VGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYV 273
Cdd:cd15132 160 PYAVSSGLLgiMIWVTTTYFFLPMLCLSFLYGFIgrkLWKSKNDLRGPNAAARERSHRQTVRILAVVVLAFIICWLPFHI 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   274 VQllNLFVTSLDATV-------NHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15132 240 GR--ILFANTEDYRTmmfsqyfNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
50-315 3.96e-28

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 111.42  E-value: 3.96e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15153   7 YIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATY-RRPSVAklINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFV 208
Cdd:cd15153  87 ICFLTCISIQRCFFLLHPFKARDWkRRYDVG--ISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKKLNFGAAIA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IYTF--LLGFLLPVLAIGLCYLLIVGKMRavalRAGWQQRRRSEK-KITRLVLMVVTVFVLCWMPFYVVQLLNLFVT--- 282
Cdd:cd15153 165 MMTVaeLFGFVIPLFIIAWCTWKTENSLR----QRNKQQQSTSEKqKALRMVRMCAAVFFICFAPYHINFLFYLMVSesi 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   283 -------SLDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15153 241 itncevsQVILQFHPISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
49-316 4.08e-28

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 111.40  E-value: 4.08e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15369   6 VYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFkIAYHFSGNDWLFGEAMCRVVTAAFYCNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVAC----NLHWPHPAW 203
Cdd:cd15369  86 CSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLGITTChdvlNEQLLMGYY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLgFLLPVLAIGLCYLLIVGKMRAVALRAgwqqrrRSEKKiTRLVLMVVTV---FVLCWMPFYVVQLLNLF 280
Cdd:cd15369 166 VYYFSIFSCLF-FFVPLIITTVCYVSIIRCLSSSSDVA------NSSKK-TRALFMAVAVfcvFVICFGPTNVLLLAHYV 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   281 VTSLDATVNH------VSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15369 238 RFAYTSTNDAsyfaylLCVCVGSISCCLDPLIYYYGSSQCQK 279
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
44-318 4.80e-28

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 110.80  E-value: 4.80e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15322   1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVaCNLHwpHPA 202
Cdd:cd15322  81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGPI-CKIN--DEK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WsavFVIYTFLLGFLLPVLAIGLCYLLIvgkmravalragWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd15322 158 W---YIISSCIGSFFAPCLIMVLVYIRI------------YQIAKNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVCD 222
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   283 -SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15322 223 cSVPETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
49-316 5.68e-28

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 111.08  E-value: 5.68e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPfGAVLCRAVLSVDGLNMFT 128
Cdd:cd15171   6 LCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSL-GNPTCKVLVALSSVGLHS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGV-WLASLLVTLPIAVFadTRPARGGEAVACNLHWPH------P 201
Cdd:cd15171  85 EALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVLaWLTAFLVTLPEFVF--YKPQMDSQKSKCAFSRPHflpaeeT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYllivgkmraVALRAGWQQRRRsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15171 163 FWKYFLTLKMNIVVLVFPLLVFIICC---------VQLRKTQRFRER-QRDLSKLVFAIMVVFLLMWAPYNIALFLSAFK 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   282 -----------TSLDATVnHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15171 233 ehfslrdckssYHLDASV-QVTKLIATTHCCVNPLLYALLDPAFRR 277
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
49-318 6.45e-28

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 110.94  E-value: 6.45e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15967   6 VYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFlVVYYLKGRKWIFGQVFCKITRFCFNLNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGG-------EAVACNLHWPh 200
Cdd:cd15967  86 GSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTNSNGTKcfdttfnDYLESYLTYS- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWSAVfviytfllGFLLPVLAIGLCY-LLIVGKMRAVALRAGWQQRrrsekkITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd15967 165 LGWTVT--------GFVIPLLIILGCYgHVVVVLCRNNNVDKGLKQR------CLKLVIILIVLFSVCYIPYHVFRNLNL 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 469169   280 FV-----------TSLDATVNH-VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15967 231 LSrilqkqgsctqWFRGIYIAHqVSRGLVCLNSALNPLVYLMGSEDILSRI 281
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
44-317 7.26e-28

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 110.66  E-value: 7.26e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFvasAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15920   1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPF---RVAYQNTAGPLSFCKIVGAFFY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPA----------RGGEAVA 193
Cdd:cd15920  78 LNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFESRNEGPcdnkcfhfrsKGLTAGG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   194 CNLhwphpawSAVFVIYTFLLGFLlpvlaigLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYV 273
Cdd:cd15920 158 INL-------TAVVIFYILSLLFL-------YFYAKISHKLYKVSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYHI 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 469169   274 VQLLNLF-----VTSLDA-----TVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15920 224 VRVPYVLaqidvISSLPWkqtlhIANELVLCLSALNSCLDPIIYFFLSSSFRRA 277
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
49-315 1.05e-27

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 110.25  E-value: 1.05e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVP-FVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15365   6 VYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPlWIDYLWNGDNWTLSGFVCIFSAFLLYTNFY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVaCNLHWPHPAWSAVF 207
Cdd:cd15365  86 TSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSFHESSSHTL-CYDKFPLEDWQARL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGkmravALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDA- 286
Cdd:cd15365 165 NLFRICLGYLLPLLIILFCYWKIYQ-----AVRSNQATEDQEKKKIFKLLLLITVTFVICFTPYHVVLLIRSIVEPCDCr 239
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   287 ------TVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15365 240 nakwlyTLYKITVALTSLNCIADPFLYCFVTESGR 274
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
44-318 1.12e-27

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 110.47  E-value: 1.12e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15048   1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVgLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHplrAATYRRPSVAK--LINLG-VWLASLLVTLPIAVFADtrPARGGEAVACNLHWP 199
Cdd:cd15048  81 YTLCTASALTIVLISLDRYLSVTK---AVKYRAKQTKRrtVLLMAlVWILAFLLYGPAIIGWD--LWTGYSIVPTGDCEV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRA--------------------VALRAGWQQRRRSEKKITRLVLM 259
Cdd:cd15048 156 EFFDHFYFTFITSVLEFFIPFISVSFFNLLIYLNIRKrsrrrplrsvpilpasqnpsRARSQREQVKLRRDRKAAKSLAI 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 469169   260 VVTVFVLCWMPFYVVQLLNLFVTSLDATVN--HVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15048 236 LVLVFLICWAPYTILTIIRSFCSGSCVDSYlyEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
49-317 4.31e-27

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 108.81  E-value: 4.31e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15379   6 VYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKdYWPFGDFTCRLVRFQFYTNLH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLrAATYRR--PSVAKLINLGVWLASLLVTLPIAVFADTRPARgGEAVACNLhwPHPAWSA 205
Cdd:cd15379  86 GSILFLTCISVQRYLGICHPL-ASWHKKkgKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQR-NRTVCYDL--SPPARST 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLL---GFLLPVLAIGLCYLLIVG----KMRAVALRAGWQQRRrseKKITRLVLMVVTVFVLCWMPFYVVQLLN 278
Cdd:cd15379 162 AYFPYGITLtrtGFLLPFAARLACYCSMATilcrVVIAVAVVAAPGEKR---GKAARMIIVVAAVFLISFLPFHYTKTRY 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   279 LFVTS----------LDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15379 239 LQVRSwdggpcttrqAFAEAYKRTRPFASMNSVLDPILFYFTQSKFRPR 287
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
49-318 5.75e-27

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 107.72  E-value: 5.75e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15323   6 VVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVaTLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPArGGEAVACNLHwpHPAWsavF 207
Cdd:cd15323  86 SSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPE-GDVYPQCKLN--DETW---Y 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIvgkmravalragWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF---VTSL 284
Cdd:cd15323 160 ILSSCIGSFFAPCLIMILVYIRI------------YRVAKAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGIcreACEV 227
                       250       260       270
                ....*....|....*....|....*....|....
gi 469169   285 DATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15323 228 PEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
48-314 1.24e-26

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 106.96  E-value: 1.24e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPfgAVLCRAVLSVDGLNMF 127
Cdd:cd15164   5 IIYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVLYFLKHSWPD--DELCLVLQSIYFINRY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWlaslLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15164  83 MSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLW----VLVIISVSLRLAWEEQEENFCFGKTSTRPSKRTLIF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 viytFLLGFLLPVLAIGLCYLLIVgkmraVALRAGWQQRRRSEKKITRLVLMV---VTVFVLCWMPFYVVQLLNLFVTSL 284
Cdd:cd15164 159 ----SLLGFFIPLIILSFCSIQVI-----RSLKKKKKTNPHEEKLIQKAIYIVsanLIVFIVCFLPLHIGLLVRFVMESN 229
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   285 DA---------TVNHVSLILSYANSCANPILYGFLSDNF 314
Cdd:cd15164 230 KAscsliqnirNFIYVASCLANANCCLDAICYYFVAKEF 268
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
50-318 1.30e-26

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 107.60  E-value: 1.30e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15981   7 YLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRpsVAKLINLGVWLASLLVTLPIAV----------FADTRPARGGEAVACNLHW 198
Cdd:cd15981  87 SVFTLVAIAVERFRCIVHPFRQKLTLR--KAIVTIVIIWVLALIIMCPSAVtltvtreehhFMVDDYNNSYPLYSCWEAW 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAG-----WQQRRRSEKKITRLVLMVVTV---FVLCWMP 270
Cdd:cd15981 165 PDTEMRKIYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRgsqgeEEEGRRVSKRKIKVINMLIIValfFTLSWLP 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 469169   271 FYVVQLLNLFVTSLDATVNHVSLI-------LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15981 245 LWTLMLLTDYGHLSEDQLNLVTVYvfpfahwLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
50-316 1.36e-26

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 107.61  E-value: 1.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15396   7 YSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVcVMCIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPlraaTYRRPSVAKL---INLgVWLASLLVTLPIAVFAD--TRPARG--------GEAVACN 195
Cdd:cd15396  87 SIFSLVLIAIERYQLIVNP----RGWKPSASHAywgIVL-IWLFSLMISIPFLIFHQltDEPFRNlsshsdfyKDKVVCI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   196 LHWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAvalRAGWQQRRR-------SEKKITRLVLMVVTVFVLCW 268
Cdd:cd15396 162 EAWPSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKK---RNSKIDRMRenesrlsENKRINTMLISIVVTFAACW 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 469169   269 MPfyvvqlLNLFVTSLDAtvNHVSL-------------ILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15396 239 LP------LNIFNVVFDW--NHEVLmschhnlvftlchLVAMVSTCINPIFYGFLNKNFQK 291
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
50-318 1.92e-26

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 106.21  E-value: 1.92e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRH-WPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15310   7 YCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVaTLVMPWVVYLEVTGGvWNFSRICCDVFVTLDVMMCT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINL---GVWLASLLVTLPIAVFADTRpargGEAVACNLHWPhpaws 204
Cdd:cd15310  87 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVSLmitAVWVLAFAVSCPLLFGFNTT----GDPTVCSISNP----- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 aVFVIYTFLLGFLLPVLAIglcyLLIVGKMRAVALRagwqqrrrsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS- 283
Cdd:cd15310 158 -DFVIYSSVVSFYLPFGVT----LLVYVRIYVVLLR---------EKKATQMLAIVLGAFIVCWLPFFLTHILNTHCQAc 223
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   284 -LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15310 224 hVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 4.29e-26

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 106.08  E-value: 4.29e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd16004   7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMaAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAatyRRPSVA-KLINLGVWLASLLVTLPIAVFADTRPARGgeAVACNLHWPHPAWSAVF 207
Cdd:cd16004  87 SIYSMTAIAADRYMAIIHPFKP---RLSAGStKVVIAGIWLVALALAFPQCFYSTVTMDQG--RTKCIVAWPGDSGGKHQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTF---LLGFLLPVLAIGLCYLLI-----VGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd16004 162 LTYHLaviVLIYLLPLAVMFVTYSIIgitlwRSAVPGHQAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILGS 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   280 FVTSL--DATVNHVSL---ILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd16004 242 FNEDIycQKYIQQVYLaifWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
49-315 5.66e-26

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 105.65  E-value: 5.66e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15370   6 VYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLkIAYHINGNNWIYGEALCKVLIGFFYGNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLrAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15370  86 CSILFMTCLSVQRYWVIVNPM-SHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLPEQLLVGDM 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLG---FLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRrseKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSL 284
Cdd:cd15370 165 FNYFLSLAigvFLFPAFLTAVAYVLMIRALKSSINDESIEKKR---KRAIKLIVTVLVMYLICFTPSNLLLVVHYFLLKN 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   285 DATVNH-----VSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15370 242 QGQSSVyafyiTALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
49-315 5.84e-26

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 105.65  E-value: 5.84e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAaLRH--WPFGAVLCRAVLSVDGLNM 126
Cdd:cd15366   6 LYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYF-LHRdnWIHGPESCKLFGFIFYTNI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVaCNLHWPHPAWSAV 206
Cdd:cd15366  85 YISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDRYNHTF-CFEKYPMEDWVAW 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYlliVGKMRAVALRAGWQQRRRSekKITRLVLMVVTVFVLCWMPFYVVQLLNLFV----- 281
Cdd:cd15366 164 MNLYRVFVGFLFPWVLMLFSY---RGILRAVRGNVSTEQQEKA--KIKRLALSLIAIVLLCFAPYHVLLLSRSVVylgkp 238
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   282 TSLDA-----TVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15366 239 CDCGFeervfTAYHVSLALTSLNCVADPILYCLVNEGAR 277
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
52-318 6.91e-26

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 105.41  E-value: 6.91e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPF-VASAAALRHwPFGAVLCRAVLSVdglnMFT- 128
Cdd:cd14968   9 LIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVgALAIPLaILISLGLPT-NFHGCLFMACLVL----VLTq 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 -SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLV-TLPIA---VFADTRPARGGEAVACNLHWPHPAW 203
Cdd:cd14968  84 sSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVgLTPMFgwnNGAPLESGCGEGGIQCLFEEVIPMD 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYtflLGFLLPVLAI-----GLCYLLIVGKMRAVALRAG---WQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQ 275
Cdd:cd14968 164 YMVYFNF---FACVLVPLLImlviyLRIFRVIRKQLRQIESLLRsrrSRSTLQKEVKAAKSLAIILFLFALCWLPLHIIN 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   276 LLNLFVTSLDA--TVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14968 241 CITLFCPECKVpkILTYIAILLSHANSAVNPIVYAYRIRKFRQTF 285
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
46-311 1.66e-25

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 104.11  E-value: 1.66e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKmKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:cd15371   3 IPAVYIIVVVLGVPSNAIILWMLFFRLR-SVCTAIFYANLAISDLLFCITLPFkIVYHLNGNNWVFGETMCRIITITFYG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWS 204
Cdd:cd15371  82 NMYCSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPFFILKQTYYLKELNITTCHDVLPECEQN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLL----GFLLPVLAIGLCYLLIVGKMRAvalragWQQRRRSEKKITRLVLMvvtVFVLCWMPFYVVQLL--- 277
Cdd:cd15371 162 SNFQFYYFISmavfGFLIPLVITIFCYISIIRTLNA------YEHKWFWYVKITALVLI---IFTICFAPSNVILIIhhf 232
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   278 NLFVTSLDATVNH--VSLILSYANSCANPILYGFLS 311
Cdd:cd15371 233 NYYYFNNDNLYSIylIALCLGSLNSCLDPFLYFLMS 268
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
49-316 2.05e-25

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 103.76  E-value: 2.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15008   5 VFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVaSAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPsvAKLINLGVWLASLLVTLPIAVFADTRPARggeavACNLHWPhPAWS-AV 206
Cdd:cd15008  85 VQIYVLLSICVDRFYTIVYPLSFKVSREK--AKKMIAASWLFDAAFVSPALFFYGSNWGP-----HCNFFLP-DSWDgAA 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVAlRAGWQQRR------RSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15008 157 YAIIHLLVGFLVPSILIILFYQKVIKYIWRIG-TDGRTVRRtmnivpRTKVKTIKMFLMLNSMFLLSWLPFYVVQLWHPR 235
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   281 VTSLD--ATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15008 236 ESDYRqsSLVFLAVTWISFSSSASKPTLYSVYNANFRR 273
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
52-325 2.28e-25

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 103.88  E-value: 2.28e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSV 130
Cdd:cd15307   9 VLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVaVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLhwPHPawsaVFVIY 210
Cdd:cd15307  89 MHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKDHASVLVNGTCQI--PDP----VYKLV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   211 TFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGwqQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNH 290
Cdd:cd15307 163 GSIVCFYIPLGVMLLTYCLTVRLLARQRSRHG--RIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISH 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   291 ----VSLILSYANSCANPILYGFLSDNFRRSFQRVLCLR 325
Cdd:cd15307 241 wvfdVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 279
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
44-318 3.07e-25

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 104.16  E-value: 3.07e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMK---TATNIYLLNLAVADEL-FMLSVPFVASAAALRH--WPFGAVLCRA 117
Cdd:cd15355   1 VLVTAIYLALFVVGTVGNSITLYTLARKKSLQhlqSTVHYHLASLALSDLLiLLLAMPVELYNFIWVHhpWAFGDAACRG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   118 VLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPI--AVFADTRPARGGEAVACN 195
Cdd:cd15355  81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIPMlfTMGEQNRSGTHPGGLICT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   196 LHWPHPAWSAVFVIYTFlLGFLLPVLAIGLCYLLI-------------------VGKMRAVALRAGWQQRRRSEKKITRL 256
Cdd:cd15355 161 PIVDTSTLKVVIQVNAF-LSFLFPMLVISVLNTLIanqltvmvnqaeqenqvctIGGQRTVLSVSMEPGRVQSLRHGVLV 239
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 469169   257 VLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVN---------HVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15355 240 LRAVVIAFVVCWLPYHVRRLMFCYVSDEQWTTFlydfyhyfyMLTNVLFYVSSAINPILYNLVSANFRQIF 310
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
44-315 3.43e-25

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 102.95  E-value: 3.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPfvasAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15163   1 LALMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLP----TRIVMYYSAGNCLTCSFVHIFS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 --LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGgeavacnlhwphp 201
Cdd:cd15163  77 yfVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILTTAIKFASCC------------- 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 aWSAVFVIYTFllGFLLPVLAIGLCYLLIvgkMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15163 144 -LSKLFALTVF--EFFLPLLIITFFTIRI---MCALSRPGLMHQSRERRMRAVQLLITVLIIFMICFTPFHVRQVAVAFN 217
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   282 TSLDATVN----HVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15163 218 PDIPHHTSlivyHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
44-318 4.22e-25

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 102.78  E-value: 4.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15049   1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIgLVSMNLYTVYLVMGYWPLGPLLCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrpARGGEAVACNLHWPHPA 202
Cdd:cd15049  81 YVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQY--FVGERTVPDGQCYIQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIvgkmravalragWQQRRRsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV- 281
Cdd:cd15049 159 DDPAITFGTAIAAFYLPVLVMTILYWRI------------YRETAR-ERKAARTLSAILLAFIITWTPYNILVLVSTFCa 225
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   282 TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15049 226 KCIPDTLWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
48-318 4.76e-25

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 102.93  E-value: 4.76e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15209   5 CVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIyPYPLILHAIFHNGWTLGQLHCQASGFIMGLSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLR-AATYRRPSVAKLINLgVWLASLLVTLPiAVFADTRpARGGEAVACNLHWPHpawSA 205
Cdd:cd15209  85 IGSIFNITAIAINRYCYICHSLQyDRLYSLRNTCCYLCL-TWLLTVLAVLP-NFFIGSL-QYDPRIYSCTFAQTV---ST 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVL---CWMPFYVVQLL----- 277
Cdd:cd15209 159 VYTITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPKLKPADVRNFLTMFVVFVLfavCWAPLNFIGLAvainp 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   278 ---------NLFVTsldatvnhvSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15209 239 kemapkipeWLFVA---------SYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-315 8.17e-25

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 102.49  E-value: 8.17e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLC---RAVLSVdglNM 126
Cdd:cd15378   7 YSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCksnRYLLHA---NL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGeaVACNLHWP--HPAWS 204
Cdd:cd15378  84 YSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNV--TKCKDYASsgDATNS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLGFLLPVLAIGLCYLLIvgkMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSL 284
Cdd:cd15378 162 LIYSLFLTVTGFLIPLCVMCFFYYKI---ALFLKNRNRQLANATSFEKPLTLVILAVVIFSVLFTPYHVMRNVRIASRLD 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   285 DATVNHVSLI-----------LSYANSCANPILYGFLSDNFR 315
Cdd:cd15378 239 SIGVSECTLIiikslyivtrpIAFLNSVINPVFYFLMGDHFR 280
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
44-316 1.19e-24

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 102.20  E-value: 1.19e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15395   1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMtIMCLPFTFVYTLMDHWVFGEAMCKLNSMVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPlraaTYRRPSV--AKLINLGVWLASLLVTLPIAVFA-----------DTRPARGG 189
Cdd:cd15395  81 CISITVSIFSLVLIAIERHQLIINP----RGWRPNNrhAYVGIAVIWVLAVLTSLPFLIFQvltdepfknvnVSLDAYKG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   190 EAVaCNLHWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLI----------VGKMRAVALRAGwqqrrrSEKKITRLVLM 259
Cdd:cd15395 157 KYV-CLDQFPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIyirlkrrnnmMDKMRDNKYRSS------ETKRINIMLIS 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 469169   260 VVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLIL-----SYANSCANPILYGFLSDNFRR 316
Cdd:cd15395 230 IVVAFAVCWLPLNIFNAVFDWNHEAIATCNHNLLFLichltAMISTCVNPIFYGFLNKNFQR 291
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
44-318 1.44e-24

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 101.80  E-value: 1.44e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15056   1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVmPFGAIELVNNRWIYGETFCLVRTSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVhplraatyRRPSVAKLINLGVW--LASLLVT------LPIAVFADTRPARGGEAVAC 194
Cdd:cd15056  81 VLLTTASIMHLCCIALDRYYAIC--------CQPLVYKMTPLRVAvmLGGCWVIptfisfLPIMQGWNHIGIEDLIAFNC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   195 NLHWPHPAW--SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVAL------RAGWQQ---------RRRSEKKITRLV 257
Cdd:cd15056 153 ASGSTSCVFmvNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAHqirslqRAGSSNheadqhrnsRMRTETKAAKTL 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 469169   258 LMVVTVFVLCWMPFYVVQLLNLFV-TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15056 233 GIIMGCFCVCWAPFFVTNIVDPFIgYRVPYLLWTAFLWLGYINSGLNPFLYAFFNKSFRRAF 294
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
49-317 2.30e-24

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 101.37  E-value: 2.30e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILrYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15924   6 LYTVIFFAGILLNGLAMWIFF-HIPSKSSFIIYLKNTVVADLLMILTFPFkILSDAGLGPWQLRTFVCRVTSVLFYFTMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15924  85 TSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVKKCSFLKSELGLKWHEI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRsEKKITRLVLMVVTVFVLCWMPFYVV-------QLLNLF 280
Cdd:cd15924 165 VNYICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSSR-RKKSNVKIFIIVAVFFVCFVPYHFAripytlsQTRDVF 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   281 VTSLDAT---VNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15924 244 DCTAENIlfyVKEATLFLSALNVCLDPIIYFFLCKSFRES 283
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-318 2.40e-24

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 101.18  E-value: 2.40e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNI---YLLNLAVADELFML-SVPFVASAAALRH--WPFGAVLCRA 117
Cdd:cd15130   1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTvryHLGSLALSDLLILLlAMPVELYNFIWVHhpWAFGDAGCRG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   118 VLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEavacnlh 197
Cdd:cd15130  81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQNESDDG------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   198 wPHPAWSA-----------VFVIYTFLLGFLLPVLAIGLCYLLIVGKMrAVALRAGWQQRRrsekkitrlvlMVVTVFVL 266
Cdd:cd15130 154 -THPGGLVctpivdtatlkVVIQVNTFMSFLFPMLVTSILNTVIANKL-VQALRRGVLVLR-----------AVVIAFVV 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 469169   267 CWMPFYVVQLLNLFVTSLDAT---------VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15130 221 CWLPYHVRRLMFCYISDEQWTtflfdfyhyFYMLTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
49-318 3.26e-24

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 100.62  E-value: 3.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15364   6 VYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHkWPWGSLACKITGYIFFCNIY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPArggEAVACNLHWPHPAWSAVF 207
Cdd:cd15364  86 ISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMREGQTE---GSHTCFETLQMDTQVAGF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIvgkMRAVALRAGWQQRRRSekKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDA- 286
Cdd:cd15364 163 YYARFCIGFAIPLAILIFTNYRI---FRSIQTSTSLTPHQKA--KVKYLAIAVIVIFLICFAPYHLVLLVRAIAFSLYPn 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   287 ----------TVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15364 238 gmcgfeeriyTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
44-318 3.45e-24

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 100.43  E-value: 3.45e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15297   1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIgVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrpARGGEAVACNLHWPHPA 202
Cdd:cd15297  81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQF--IVGGRTVPEGECYIQFF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYllivgkmravalragWQQRRRS--EKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15297 159 SNAAVTFGTAIAAFYLPVIIMTVLY---------------WQISRASsrEKKVTRTILAILLAFIITWTPYNVMVLINTF 223
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   281 VTS-LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15297 224 CAScIPNTVWTIGYWLCYINSTINPACYALCNATFKKTF 262
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
52-318 3.92e-24

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 100.25  E-value: 3.92e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVAS-AAALRHWPFGAVLCRAVLSVDGLNMFTSV 130
Cdd:cd15199   9 LEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYfYLNGNRWSLGGGTCKALLFMLSLSRGVSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRparggEAVACNLHWPHP--AWSAVFV 208
Cdd:cd15199  89 AFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQPK-----NFTECNSFSPKDdeDFSDTWQ 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 IYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRsekKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD--- 285
Cdd:cd15199 164 EAVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDVGKQPKLQ---RAMALVTSVVVVFGFCFLPCFLARVLMLIFQNKEscn 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   286 -----ATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15199 241 alniaVHTYDVTMCLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
55-318 5.51e-24

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 100.12  E-value: 5.51e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCL 133
Cdd:cd15312  12 LLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVmPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   134 TVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIaVFADTRpARGGE----AVAC--------NLHWPhp 201
Cdd:cd15312  92 CFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGV-VFSEVN-LEGIEdyvaLVSCtgscvlifNKLWG-- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 awsavfvIYTFLLGFLLP-VLAIGL-CYLLIVGKMRAVALRAGWQQRR---------RSEKKITRLVLMVVTVFVLCWMP 270
Cdd:cd15312 168 -------VIASLIAFFIPgTVMIGIyIKIFFVARKHAKVINNRPSVTKgdsknklskKKERKAAKTLSIVMGVFLLCWLP 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   271 FYVVQLLNLFVT-SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15312 241 FFVATLIDPFLNfSTPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
49-316 1.40e-23

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 99.06  E-value: 1.40e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVI--LRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLN 125
Cdd:cd15147   6 VYSIIFVLGLIANCYVLWVFarLYPSKKLNEIKIFMVNLTIADLLFLITLPFwIVYYHNEGNWILPKFLCNVAGCLFFIN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTR--PARGGEAVACNLHWPHPAW 203
Cdd:cd15147  86 TYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTNtvKIDSGNFTRCFEGYEKDNS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLG-FLLPVLAIGLCYLLIVgkmRAVALRAGWQQRRRSEK-KITRLVLMVVTVFVLCWMPFYVVQL----- 276
Cdd:cd15147 166 KPVLIIHFIIIGlFFLVFLLILVCNLVIA---RTLLSQPVQGQRNAGVKrRALWMVCTVLAVFVICFVPHHVVQGpwtla 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   277 ----LNLFVTSLDATVN---HVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15147 243 vlqqWRYWDCQFRQALNdahQITLCLMSTNCVLDPVIYCFLTKKFRK 289
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
44-318 1.71e-23

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 99.06  E-value: 1.71e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15317   1 VIIYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVmPFSMIRTVETCWYFGDLFCKFHTGLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFA--DTRPARGGEAVACnLHWPH 200
Cdd:cd15317  81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGanDEGLEEYSSEISC-VGGCQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWSAVFVIYTFLLgFLLPVLAIGLCYLLI-------------VGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLC 267
Cdd:cd15317 160 LLFNKIWVLLDFLT-FFIPCLIMIGLYAKIflvarrqarkiqnMEDKFRSSEENSSKASASRERKAAKTLAIVMGIFLFC 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   268 WMPFYVVQLLNLFVT-SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15317 239 WLPYFIDTIVDEYSNfITPAIVFDAVIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
51-318 2.02e-23

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 98.83  E-value: 2.02e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15959   8 SLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMgLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVAC--NLHWPHPAWSAVF 207
Cdd:cd15959  88 IETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQWWRDGADEEAQRCydNPRCCDFVTNMPY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCY------------LLIVGKMR--------AVALRAGWQQRRR----SEKKITRLVLMVVTV 263
Cdd:cd15959 168 AIVSSTVSFYVPLLVMIFVYvrvfvvatrqvrLIRKDKVRfppeesppAESRPACGRRPSRllaiKEHKALKTLGIIMGT 247
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   264 FVLCWMPFYVVQLLNLFVTSLDATVNHVSL-ILSYANSCANPILYgFLSDNFRRSF 318
Cdd:cd15959 248 FTLCWLPFFVANIIKVFCRSLVPDPAFLFLnWLGYANSAFNPIIY-CRSPDFRSAF 302
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
50-316 3.13e-23

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 97.87  E-value: 3.13e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15152   7 YTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRpSVAKLINLGVWLASLLVTLPiavFADTRPARGGEAVACNLHWP----HPAWSA 205
Cdd:cd15152  87 IYFLVCISVRRCLYLIYPFRYNDCKR-KCDVYISIAGWLVVCVGCLP---FPLLRQSQDTNPTCCFADLPlrnvGLTTSV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAvalRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS-- 283
Cdd:cd15152 163 IMLTIAELTGFVTPLLIVLYCSWKTVMSLRE---KTPVLQDLGEKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSnk 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   284 --------LDATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15152 240 iksctarkVILIFHPVALCLASLNSCLDPVIYYFTTDEFKR 280
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
49-320 3.66e-23

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 97.72  E-value: 3.66e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMK-TATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15170   6 VYIITFLIGLPANLLAFYTFIRKVRRKpTPIDILLLNLTVSDLIFLLFLPFkMAEAASGMIWPLPYFLCPLSSFIFFSTI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLL---VTLPIAVFADTRPARGGEAVAC-------NL 196
Cdd:cd15170  86 YISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFShcsIVYIVEYHIDSENTSVTNNSRCydnftpeQL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   197 HWPHPAWSAVFVIYtfllgFLLPVLAIGLCYlliVGKMRAVALRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQL 276
Cdd:cd15170 166 KILLPVRLELFLVL-----FCIPFLITCFCY---INFIRILSSLPHISRQRK--QRAIGLAVATLLNFIVCFAPYNISHV 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   277 LNlFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQR 320
Cdd:cd15170 236 VG-FIQRKSPEWRMYALLLSTLNACLDPIIFYFSSSAVRRAFKE 278
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
51-318 4.45e-23

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 98.05  E-value: 4.45e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15958   8 ALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMgLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPIAVFADTrpARGGEAVACnlhWPHPAW----- 203
Cdd:cd15958  88 IETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSfLPIMMHWWR--DEDDQALKC---YEDPGCcdfvt 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIV--------------GKMRAVALRAGWQQRRR-------SEKKITRLVLMVVT 262
Cdd:cd15958 163 NRAYAIASSIISFYIPLLIMIFVYLRVYreakkqikkidkceGRFHNTLTGLGRKCKRRpsrilalREQKALKTLGIIMG 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 469169   263 VFVLCWMPFYVVQLLNLFVTSLDATVNHVSL-ILSYANSCANPILYgFLSDNFRRSF 318
Cdd:cd15958 243 VFTLCWLPFFLVNVVNVFNRELVPDWLFVFFnWLGYANSAFNPIIY-CRSPDFRKAF 298
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
55-317 6.38e-23

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 97.11  E-value: 6.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-ELFMLSVPFVASAAALRHWPFGAVLCRAvlsVDGLNMF---TSV 130
Cdd:cd15073  12 IISTISNGIVLVTFVKFRELRTPTNALIINLAVTDlGVSIIGYPFSAASDLHGSWKFGYAGCQW---YAFLNIFfgmASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHP--LRAATYRRPSVaklINLGVWL-ASLLVTLPIAVFADTRPARGGeaVACNLHWPHPAWSAV- 206
Cdd:cd15073  89 GLLTVVAVDRYLTICRPdlGRKMTTNTYTV---MILLAWTnAFFWAAMPLVGWASYALDPTG--ATCTINWRKNDSSFVs 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRR---SEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF--V 281
Cdd:cd15073 164 YTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIdwtDQNDVTKMSVIMIVMFLVAWSPYSIVCLWASFgeP 243
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   282 TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15073 244 KKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRRA 279
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
49-318 7.03e-23

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 96.93  E-value: 7.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15314   6 FLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVgGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACN-----LHwphpa 202
Cdd:cd15314  86 ASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLELNIKGIYYNHVACEggclvFF----- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 wSAVFVIYTFLLGFLLPVLaIGLCyllIVGKMRAVALRagwQQR-------------RRSEKKITRLVLMVVTVFVLCWM 269
Cdd:cd15314 161 -SKVSSVVGSVFSFYIPAV-IMLC---IYLKIFLVAQR---QARsiqsartksgassSKMERKATKTLAIVMGVFLLCWT 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   270 PFYVVQLLNLFVT-SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15314 233 PFFLCNIIDPFINySIPPVLIEVLNWLGYSNSTLNPFIYAFFYSWFRKAF 282
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
50-317 8.48e-23

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 96.69  E-value: 8.48e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15148   7 YSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFrILYHVNNNQWTLGPLLCKVVGNLFYMNMYI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADtrpaRGGEAVAC----NLHwpHPAWS 204
Cdd:cd15148  87 SIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIVLTE----KNEESTKCfqykDRK--NAKGK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVF---VIYTFLLGFLLPVLAIGLC--YLLIVGKMRAVALRAGWQQRrrsekkITRLVLMVVTVFVLCWMP------FYV 273
Cdd:cd15148 161 AIFnflIVAMFWLVFLLLILSYGKIakKLLRISRDKPDFPNAAKYNR------TARKSFFVLFIFTVCFVPyhafriFYI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   274 VQLLN---LFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15148 235 TSQLQnnsCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRKV 281
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
52-326 9.62e-23

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 96.51  E-value: 9.62e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH--WPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15305   9 IIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDyaWPLPRYLCPIWISLDVLFSTAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHpawsavFVI 209
Cdd:cd15305  89 IMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPIPVIGLQDDEKVFVNGTCVLNDEN------FVL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   210 YTFLLGFLLPVLAIGLCYLLIVGKMRAvalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV-----TSL 284
Cdd:cd15305 163 IGSFVAFFIPLIIMVITYCLTIQVLQR-------QQAINNERRASKVLGIVFFLFLIMWCPFFITNILSVLCkeacdQKL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   285 DATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVlcLRC 326
Cdd:cd15305 236 MEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNY--IRC 275
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
48-318 1.21e-22

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 97.00  E-value: 1.21e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKT-ATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAvLCRAVLSVDGLN 125
Cdd:cd15320   6 CFLSVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVaVLVMPWKAVAEIAGFWPFGS-FCNIWVAFDIMC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPIAV---------FADTRPARGGEAV-AC 194
Cdd:cd15320  85 STASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfIPVQLnwhkakptsFLDLNASLRDLTMdNC 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   195 NlhwphPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIV------------------------------GKMRAVALRAGWQ 244
Cdd:cd15320 165 D-----SSLNRTYAISSSLISFYIPVAIMIVTYTRIYriaqkqirrisaleraavhakncqnstgnrGSGDCQQPESSFK 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   245 QRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS-------LDATVNHVSLILSYANSCANPILYGFLSDnFRRS 317
Cdd:cd15320 240 MSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPtstepfcISSTTFDVFVWFGWANSSLNPIIYAFNAD-FRKA 318

                .
gi 469169   318 F 318
Cdd:cd15320 319 F 319
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
49-316 1.49e-22

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 96.01  E-value: 1.49e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILrYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15969   6 LYLIIFIGSILLNGLAVWIFF-HIRNKTSFIFYLKNIVIADLLMTLTFPFkIIQDSGLGPWNFNFFLCRYTSVLFYASMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVF 207
Cdd:cd15969  85 TSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTEDNIHDCSKLKSPLGVKWHTA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRseKKITRLVLMVVTVFVLCWMPFYVVQL---LNLFVTSL 284
Cdd:cd15969 165 VSYINICIFVAVLVILIVCYISISRYIYKSSKQFISSSSRT--RKHNQSIRVVVAVFFVCFLPYHLCRIpftFSQLDKIL 242
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   285 DATVNHV-------SLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15969 243 DCTIKTIlyyckeaTLFLSACNVCLDPIIYFFMCRSFSQ 281
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
44-318 1.72e-22

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 95.68  E-value: 1.72e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLvGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-FMLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15215   1 IRSVLIVIFLCA-SLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLqTVLVMPWVIATSVPLFWPLDSHLCTALVVLM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHWphpA 202
Cdd:cd15215  80 HLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTP-PLYGWGQAAFDERNALCSVIW---G 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYllivgkmrAVALRAGwqqRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV- 281
Cdd:cd15215 156 SSYSYTILSVVSSFVLPVIIMLACY--------SMVFRAA---RRCYHCKAAKVIFIIIFSYVLSMGPYSFLSVLAVWVd 224
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   282 TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15215 225 TQVPQWVISIILWLFFLQCCIHPYIYGYMHKSIKKEF 261
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
55-318 1.72e-22

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 95.96  E-value: 1.72e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCL 133
Cdd:cd15086  12 TFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVcVLGTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLISL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   134 TVLSVDRYVAVVHPLRA--ATYRRpsvAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHWP-HPAWSAVFVIY 210
Cdd:cd15086  92 AVLSYERYCTLLRPTEAdvSDYRK---AWLGVGGSWLYSLLWTLP-PLLGWSSYGPEGPGTTCSVQWTsRSANSISYIIC 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   211 TFLLGFLLPVLAIGLCYLLIVGKMRAVAlRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS--LDATV 288
Cdd:cd15086 168 LFIFCLLLPFLVMVYCYGRLLYAIKQVG-KINKSTARKREQHVLLMVVTMVICYLLCWLPYGVMALLATFGKPglVTPVA 246
                       250       260       270
                ....*....|....*....|....*....|
gi 469169   289 NHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15086 247 SIVPSILAKSSTVVNPIIYVFMNKQFYRCF 276
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
48-318 1.83e-22

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 95.96  E-value: 1.83e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVP-FVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15000   4 SMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPwMFLVHDFFQNYVLGSVGCKLEGFLEGSLL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRpSVAKLINLgVWLASLLVTLPIAVFADTRparggEAVACNLHWPHPAWSAV 206
Cdd:cd15000  84 LASVLALCAVSYDRLTAIVLPSEARLTKR-GAKIVIVI-TWIVGLLLALPLAIYRSYR-----ERQWKNFLETYCAENTQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FV-IYTFLLGFLL---PVLAIGLCYLLIVGKM---RAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd15000 157 VLpIYWHVIITVLvwlPLGIMLICYSAIFWKLdkyERRVLRREHPSVVRYKKKAAKTLFIVLITFVVCRIPFTALIFYRY 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   280 FVTSLDATVNHVS---LILSYA-------NSCANPILYGFLSDNFRRSF 318
Cdd:cd15000 237 KLVPNDNTQNSVSgsfHILWFAskylmflNAAVNPLIYGFTNENFRKAF 285
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
60-320 1.94e-22

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 95.67  E-value: 1.94e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    60 GNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAL--RHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLS 137
Cdd:cd15306  17 GNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILfeAMWPLPLVLCPIWLFLDVLFSTASIMHLCAIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   138 VDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLhwpHPAWSAVFVIYTFLLGFL 217
Cdd:cd15306  97 LDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVL---TKERFGDFILFGSLAAFF 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   218 LPVLAIGLCYLLIVGKMRavalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATV----NHVSL 293
Cdd:cd15306 174 TPLAIMIVTYFLTIHALR--------KQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDSCNQTTlqmlMEIFV 245
                       250       260
                ....*....|....*....|....*..
gi 469169   294 ILSYANSCANPILYGFLSDNFRRSFQR 320
Cdd:cd15306 246 WIGYVSSGVNPLVYTLFNKTFRDAFGR 272
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
47-311 2.05e-22

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 95.57  E-value: 2.05e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    47 QCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPF-GAVLCRAVLSVDGLN 125
Cdd:cd14964   2 TIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSrPQALCYLIYLLWYGA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRParggEAVACNLHWPHPAWSA 205
Cdd:cd14964  82 NLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIP----RYNTLTGSCYLICTTI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEK--KITRLVLMVVTVFVLCWMPFYVVQLLNL---F 280
Cdd:cd14964 158 YLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKnlKATKSLLILVITFLLCWLPFSIVFILHAlvaA 237
                       250       260       270
                ....*....|....*....|....*....|.
gi 469169   281 VTSLDATVNhVSLILSYANSCANPILYGFLS 311
Cdd:cd14964 238 GQGLNLLSI-LANLLAVLASTLNPFIYCLGN 267
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
55-318 2.29e-22

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 95.05  E-value: 2.29e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCL 133
Cdd:cd15330  12 LCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVsVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   134 TVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrPARGGEAVACNLHWPHPawsavFVIYTFL 213
Cdd:cd15330  92 CAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRT-PEDRSDPDACTISKDPG-----YTIYSTF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   214 LGFLLPVLAIglcyLLIVGKMRAVALRagwqqrrrsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS-------LDA 286
Cdd:cd15330 166 GAFYIPLILM----LVLYGRIFKAAAR---------ERKTVKTLGIIMGTFILCWLPFFIVALVLPFCEStchmpelLGA 232
                       250       260       270
                ....*....|....*....|....*....|..
gi 469169   287 TVNHvsliLSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15330 233 IINW----LGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
44-317 3.06e-22

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 95.46  E-value: 3.06e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTA-TNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSV 121
Cdd:cd15382   1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTFIMmPLEIGWAATVAWLAGDFLCRLMLFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSvaKLINLGVWLASLLVTLP-IAVF-ADTRPARGG--EAVACNLh 197
Cdd:cd15382  81 RAFGLYLSSFVLVCISLDRYFAILKPLRLSDARRRG--RIMLAVAWVISFLCSIPqSFIFhVESHPCVTWfsQCVTFNF- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   198 WPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMR---------AVALRAGWQQRR-------RSEKKITRLVLMVV 261
Cdd:cd15382 158 FPSHDHELAYNIFNMITMYALPLIIIVFCYSLILCEISrkskekkedVSEKSSSVRLRRssvglleRARSRTLKMTIVIV 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   262 TVFVLCWMPFYVVQLLNLF----VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15382 238 LVFIICWTPYFIMSLWYWFdresASKVDPRIQKGLFLFAVSNSCMNPIVYGYFSIDLRRE 297
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
48-308 3.76e-22

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 95.20  E-value: 3.76e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15384   5 VVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFfCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAAtyRRPSVAKLINLGVWLASLLVTLP-IAVFADTRPARGGEAVACNLHWPHPA-WS 204
Cdd:cd15384  85 YLSTYITVLISLDRCVAILYPMKRN--QAPERVRRMVTVAWILSPIFSIPqAVIFHVERGPFVEDFHQCVTYGFYTAeWQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 A-VFVIYTFLLGFLLPVLAIGLCYLLIV------GKMR---AVALRAGWQQRRR----SEKKITRLVLMVVTVFVLCWMP 270
Cdd:cd15384 163 EqLYNMLSLVFMFPIPLVIMVTCYVLIFitlsksSRDFqglEIYTRNRGPNRQRlfhkAKVKSLRMSAVIVTAFILCWTP 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   271 FYVVQLLNLFVTS--LDATVNHVSLILSYANSCANPILYG 308
Cdd:cd15384 243 YYVIMIWFLFFNPypLNDILFDVIFFFGMSNSCVNPLIYG 282
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
44-318 6.63e-22

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 94.07  E-value: 6.63e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVLSVD 122
Cdd:cd15200   1 AFLAPVLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEvWRFGATACQVNLFML 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIavFADTRPARGGEAVACNLHwPHPA 202
Cdd:cd15200  81 SMNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHL--LLLDHVQSNSTCLSYDHG-TDPS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRsekkiTRLVLMVVTVFVLCWMP---FYVVQLLNL 279
Cdd:cd15200 158 ASDRWHRILFFLEFFLPLGIILFCIFSIILTLKQRKLAKQAGPQRA-----VKVLAVIVLVYTVCFLPsilFALASLVAF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   280 FVTS-----LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15200 233 KVSQcrsldLCTQLFHGSLAFTYLNSALDPVLYCFSSPSFLNQS 276
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
44-318 8.78e-22

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 93.40  E-value: 8.78e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15324   1 ALIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGSTWCAFYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPArggEAVACNLHWphpa 202
Cdd:cd15324  81 VLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEW---ECLLNDETW---- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 wsavFVIYTFLLGFLLPVLAIGLCYLLI--VGKMRavalragwqqrrrsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15324 154 ----YILSSCTVSFFAPGLIMILVYCKIyrVAKMR--------------EKRFTFVLAVVMGVFVLCWFPFFFTYSLHAV 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   281 ----VTSLDATVNHVSLIlSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15324 216 crkrCGIPDALFNLFFWI-GYCNSSVNPIIYTIFNRDFRKAF 256
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
52-318 1.23e-21

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 93.07  E-value: 1.23e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR--HWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15304   9 IVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYgyRWPLPSKLCAVWIYLDVLFSTAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHwphpawSAVFVI 209
Cdd:cd15304  89 IMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLA------DENFVL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   210 YTFLLGFLLPVLAIGLCYLLIVGKMravalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS-----L 284
Cdd:cd15304 163 IGSFVAFFIPLTIMVITYFLTIKSL---------QQSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAVICKEscnevV 233
                       250       260       270
                ....*....|....*....|....*....|....
gi 469169   285 DATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15304 234 IGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
49-314 1.75e-21

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 93.71  E-value: 1.75e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD---ELFMLsVPFVASAAALRhWPFGAVLCRAVLSVDGLN 125
Cdd:cd15386   6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDlvvALFQV-LPQLIWEITYR-FQGPDLLCRAVKYLQVLS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRaaTYRRPSVAKLINLGV-WLASLLVTLP-IAVFADTRPARGGEAVACNLHWPHPAW 203
Cdd:cd15386  84 MFASTYMLIMMTVDRYIAVCHPLR--TLQQPSRQAYLMIGAtWLLSCILSLPqVFIFSLREVDQGSGVLDCWADFGFPWG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIV--------GKMRA-VALRAGWQQR------------RRSEKKITRLVLMVVT 262
Cdd:cd15386 162 AKAYITWTTLSIFVLPVAILIVCYSLICyeicknlkGKTQTsRSEGGGWRTQgmpsrvssvrtiSRAKIRTVKMTFVIVL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 469169   263 VFVLCWMPFYVVQLLNlfVTSLDA-------TVNHVSLILSYANSCANPILYGFLSDNF 314
Cdd:cd15386 242 AYIACWAPFFSVQMWS--VWDENApdedssdFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
49-318 1.76e-21

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 93.57  E-value: 1.76e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15065   5 FLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVmTFAVVNDLLGYWLFGETFCNIWISFDVMCST 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPIAvFADTRPARGGEAVACNLHWPHPA---- 202
Cdd:cd15065  85 ASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISfLPIH-LGWHRLSQDEIKGLNHASNPKPScald 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCY--LLIVGKMRAVALRAGWQQ------------------RRRSEKKITRLVLMVVT 262
Cdd:cd15065 164 LNPTYAVVSSLISFYIPCLVMLLIYsrLYLYARKHVVNIKSQKLPsesgskfqvpslsskhnnQGVSDHKAAVTLGIIMG 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 469169   263 VFVLCWMPFYVVQLLNLFVTSLDATVNHVSLI-LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15065 244 VFLICWLPFFIINIIAAFCKTCIPPKCFKILTwLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
44-323 1.77e-21

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 92.70  E-value: 1.77e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKmKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPfGAVLCRAVLSVD 122
Cdd:cd14973   1 LVIFSLTVLLSLCGLVGNGLVLWLLGFRIK-RNPFSVYILNLAAADFLFLScQAIQSLEDLLGGSLP-GFALCRLLATLM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPlraATYR--RPSVAKLI-NLGVWLASLLVTLPIAVFADTRparggeavacnLHWP 199
Cdd:cd14973  79 FFSYTVGLSLLAAISTERCLSVLFP---IWYRchRPKHLSAVvCALLWALSLLLSVLESYFCGFL-----------FWKF 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIvgkmravaLRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL-N 278
Cdd:cd14973 145 NESACRTFNFLSALLFLLLFLVMCVSSLTLL--------IRVQCSSQRRPPTRLYVVILLTVLVFLLCGLPLGIYWFLlL 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 469169   279 LFVTSLDATVNHVSLILSYANSCANPILYGF--------LSDNFRRSFQRVLC 323
Cdd:cd14973 217 WFSNYLFHTFHPISDLLSCVNSSANPIIYFFvgslrgrrLREPLRVVLQRALR 269
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
49-318 2.20e-21

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 93.33  E-value: 2.20e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAL-RHWPFGAVLCRAVLSVDGL--- 124
Cdd:cd14996   6 IYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKgFYWKYQSTQCRIANFFGTLvih 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 -NMFTSVFCLTVLSVDRYVAVV---HPLRAAT-------------YRRPSVAKLINLGVWLASLLVTLPIAVFADTRPAR 187
Cdd:cd14996  86 vSMCVSILILSWIAISRYATLMkhdSATQKQScyekifyghflkrFRQPKFARYLCIYIWGVVLCIIIPVVVYYSVREAD 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   188 GGEAVAC-NLHWP---HPAWSAVFVIYTFLLGFLLPVLaigLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTV 263
Cdd:cd14996 166 EDGESLCyNRQVElgaKGSQIAGLIATTFFFLFFLVVL---LSYYSFVNHLRRIQKNTCISEKDLIYRSVKRNILIIQAL 242
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 469169   264 FVLCWMP-------FYVV------QLLNLFVtsldaTVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14996 243 LVVCFLPyhifkpvFYVLhqredcQQLNYLI-----ETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
49-317 2.45e-21

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 92.96  E-value: 2.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKmKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15150   6 LYTVLFIVGLTMNGLAMRVFFQIPS-KSNFIIFLKNTVISDLLMILTFPFkILSDAKLGSWPLRGFVCQVTSVIFYFTMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFAdTRPARGGEAVACNLHWPHPA--WSA 205
Cdd:cd15150  85 ISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILT-NRQPTPKNVKKCSLLKSEFGlvWHE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VfVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGwQQRRRSEKKITRLVLMVVTVFVLCWMPFY-------VVQLLN 278
Cdd:cd15150 164 I-VNYICQVIFWVNFLIVIVCYTLITKELYKSYKRTR-GVGKVSRKKVNVKVFIIIAVFFICFVPFHfaripytLSQTRD 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   279 LFVTSLDATVNHV---SLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15150 242 VFDCTAKNTLFYVkesTLWLTSLNACLDPFIYFFLCKSFRNS 283
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
58-318 2.46e-21

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 92.69  E-value: 2.46e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    58 LVGNALVIFVILRYAKMKTATNIYLL-NLAVADELFMLSVPFVASAAALRHWPFG--------AVLCRAVLSVDGLNMFT 128
Cdd:cd14980  15 LIGNILVIIWHISSKKKKKKVPKLLIiNLAIADFLMGIYLLIIAIADQYYRGRYAqyseewlrSPPCLLACFLVSLSSLM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRaatYRRPSV--AKLINLGVWLASLLVTLPIAVFADTRPARG---GEAVAC---NLHWPH 200
Cdd:cd14980  95 SVLMMLLITLDRYICIVYPFS---NKRLSYksAKIILILGWLFSIIFAAIPILYSINQPGDNrlyGYSSICmpsNVSNPY 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 -PAWSAVFVIYTFLLgfllpVLAIGLCYLLIVGKMRAVALRAGWQQRRRsEKKIT-RLVLMVVTVFVlCWMPFYVVQLLN 278
Cdd:cd14980 172 yRGWLIAYLLLTFIA-----WIIICILYILIFISVRKSRKSARRSSSKR-DKRIAiRLALILITDLI-CWLPYYIVIFSG 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   279 LF-VTSLDATVNHVSLILSYA-NSCANPILYGFLSDNFRRSF 318
Cdd:cd14980 245 LLtSTEIDIHVLQFIAILALPlNSAINPYLYTLTTPTFKRDF 286
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
46-318 3.26e-21

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 91.91  E-value: 3.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:cd15335   3 IVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVaVLVMPLSITYIVMDTWTLGYFICEIWLSVDMT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEavACNLHWPHpaws 204
Cdd:cd15335  83 CCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPS--QCIIQHDH---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLGFLLPVLAIglcyLLIVGKMRAVALRagwqqrrrsEKKITRLVLMVVTVFVLCWMPFYVVQLL-NLFVTS 283
Cdd:cd15335 157 VIYTIYSTFGAFYIPLTLI----LILYYRIYHAASR---------ERKAARILGLILGAFILSWLPFFIKELIvGLSVMT 223
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   284 LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15335 224 VSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
49-317 4.21e-21

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 91.81  E-value: 4.21e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15078   6 LIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVsLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHplraATYRRPSVAKLINLGVWLASLLVTlPIAVFADTRPARGGEAVACNLHWPHP-AWSAV 206
Cdd:cd15078  86 VSIMTLTVLAYERYIRVVH----AKVVNFSWSWRAITYIWLYSLAWT-GAPLLGWNRYTLEVHGLGCSFDWKSKdPNDTS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCY---LLIVGKMRAVALRAGWQQRR--RSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15078 161 FVLLFFLGCLVVPLGIMAYCYghiLYEIRMLRSVEDLQTFQVIKilKYEKKVAKMCLLMISTFLICWMPYAVVSLLVTSG 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   282 TS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15078 241 YSklVTPTIAIIPSLFAKSSTAYNPVIYIFMIRKFRQC 278
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
44-318 6.95e-21

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 91.85  E-value: 6.95e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15957   1 VGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVvPFGAAHILLKTWTFGNFWCEFWTSID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPIAVfaDTRPARGGEAVAC--NLHWP 199
Cdd:cd15957  81 VLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSfLPIQM--HWYRATHQEAINCyaEETCC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAVFVIYTFLLGFLLPVLAIGLCY----------LLIVGKMRA---------VALRAGWQQRRRS-----EKKITR 255
Cdd:cd15957 159 DFFTNQAYAIASSIVSFYVPLVIMVFVYsrvfqeakrqLQKIDKSEGrfhnqnidqNGSGGGGGNRRRSkfclkEHKALK 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 469169   256 LVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSL-ILSYANSCANPILYgFLSDNFRRSF 318
Cdd:cd15957 239 TLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLnWIGYVNSGFNPLIY-CRSPDFRIAF 301
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
45-318 7.21e-21

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 91.50  E-value: 7.21e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15402   2 ALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIyPYPLVLTSIFHNGWNLGYLHCQISGFLMG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRpARGGEAVACNLhwpHPAW 203
Cdd:cd15402  82 LSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVP-NLFVGSL-QYDPRIYSCTF---AQSV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVL---CWMPfyvVQLLNLF 280
Cdd:cd15402 157 SSAYTIAVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPDNKPKLKPHDFRNFVTMFVVFVLfavCWAP---LNFIGLA 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   281 VTSLDATVNH--------VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15402 234 VAVDPETIVPripewlfvASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-318 7.37e-21

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 91.84  E-value: 7.37e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-FMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15976   6 VSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLhIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQKASVG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFAD--TRPARGGEAVACNLhwpHPAWSA 205
Cdd:cd15976  86 ITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIGFDmiTMDYKGELLRICLL---HPIQKT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIY--------TFLLGFLLPVLAIGLCYLLIVGKM------RAVALRAGWQQRRrsekKITRLVLMVVTVFVLCWMPF 271
Cdd:cd15976 163 AFMQFyktakdwwLFSFYFCLPLACTAVFYTLMTCEMlrkkngMQIALNDHLKQRR----EVAKTVFCLVLVFALCWLPL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 469169   272 YVVQLLNLFV-----------TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15976 239 HLSRILKLTIydekdpnrcelLSFFLVLDYIGINMASLNSCINPIALYLVSKRFKNCF 296
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
44-318 7.64e-21

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 90.80  E-value: 7.64e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd17790   1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIgAFSMNLYTTYILMGHWALGTVACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPA-RGGEAVACNLHWPHp 201
Cdd:cd17790  81 YVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGeRTVLAGQCYIQFLS- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 awSAVFVIYTFLLGFLLPVLAIGLCYllivgkmravalragWQQRRRS--EKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd17790 160 --QPIITFGTAIAAFYLPVTIMIILY---------------WRIYRETikEKKAARTLSAILLAFILTWTPYNIMVLVST 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   280 FVTS-LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd17790 223 FCKDcVPKTLWELGYWLCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
61-319 8.60e-21

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 90.78  E-value: 8.60e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    61 NALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVD 139
Cdd:cd15334  18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVaVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   140 RYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHwphpawsAVFVIYTFLLGFLLP 219
Cdd:cd15334  98 RYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSREDECIIKHDH-------IVFTIYSTFGAFYIP 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   220 VLAIglcyLLIVGKMRAVALRagwqqrrrsEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLI--LSY 297
Cdd:cd15334 171 LALI----LILYYKIYRAATR---------ERKAATTLGLILGAFVICWLPFFVKEVIVNTCDSCYISEEMSNFLtwLGY 237
                       250       260
                ....*....|....*....|..
gi 469169   298 ANSCANPILYGFLSDNFRRSFQ 319
Cdd:cd15334 238 INSLINPLIYTIFNEDFKKAFQ 259
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
43-326 9.09e-21

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 91.16  E-value: 9.09e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    43 MVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSV 121
Cdd:cd15299   3 VVLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIgVISMNLFTTYIIMNRWALGNLACDLWLSI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVF----ADTRPARGGEAVACNLH 197
Cdd:cd15299  83 DYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFwqyfVGKRTVPPDECFIQFLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   198 WPhpawsaVFVIYTFLLGFLLPVLAIGLCYllivgkmravalragWQQRRRS--EKKITRLVLMVVTVFVLCWMPFYVVQ 275
Cdd:cd15299 163 EP------IITFGTAIAAFYLPVTIMTILY---------------WRIYKETikEKKAAQTLSAILLAFIITWTPYNIMV 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   276 LLNLFVTS-LDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRC 326
Cdd:cd15299 222 LVNTFCDScIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQC 273
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
50-315 1.06e-20

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 90.65  E-value: 1.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15166   7 YSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIaVFADTRPARGGEAVAC----NLHWPHPAWSA 205
Cdd:cd15166  87 LWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPL-LFLYEDPDKASNFTTClkmlDIIHLKEVNVL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLlgFLLPVLAIGLCYLLIVGKMraVALRAGWQQRRRSEKKITRLVLMVVTVFVlCWMPFYVVQLLNLFVTSLD 285
Cdd:cd15166 166 NFTRLIFF--FLIPLFIMIGCYLVIIHNL--VHGRTSKLKPKVKEKSIRIIITLIVQVLV-CFVPFHICFAFLMLQNGDN 240
                       250       260       270
                ....*....|....*....|....*....|..
gi 469169   286 A--TVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15166 241 SynPWAAFTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
49-313 1.16e-20

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 90.99  E-value: 1.16e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD---ELFMLSVPFVASAAALRHWPfgAVLCRAVLSVDGLN 125
Cdd:cd15388   6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADlvvAFFQVLPQLVWDITDRFRGP--DVLCRLVKYLQVVG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPL-----RAATYRRPSVAKlinlgvWLASLLVTLP-IAVFADTRPARGgeAVACNLHWP 199
Cdd:cd15388  84 MFASSYMIVAMTFDRHQAICRPMvtfqkGRARWNGPVCVA------WAISLILSLPqVFIFSKVEVAPG--VYECWACFI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAVFVIYTFLLGFLLPVLAIGLCYLLI--------------VGKMRAVALRAGWQQRRRSE-----KKITRLVLMV 260
Cdd:cd15388 156 EPWGLKAYVTWITLVVFVLPTLIITVCQVLIfkeihiniylksqiIVAVVKKKQLLSSRASSVAEvskamIKTVKMTLVI 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 469169   261 VTVFVLCWMPFYVVQLLNLFVTS--LDATVNHVSLILSYANSCANPILYGFLSDN 313
Cdd:cd15388 236 VLVYVLCWAPFFLVQLWSVWDPKapTEGATFTILMLLASLNSCTNPWIYMAFSSS 290
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
52-317 2.07e-20

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 90.30  E-value: 2.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLV----GNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15318   5 LACAIGMLiivlGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVlPFSTIRSVESCWYFGDSFCRLHTCLDTLFC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTlpiAVFADTRPARGGEAvacnlHWPH--PAWS 204
Cdd:cd15318  85 LTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYT---SVFLYTKAVEEGLA-----ELLTsvPCVG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLG------FLLPVLAIGLCY--LLIVGKMRAVALRAGWQQRR---RSEKKITRLVLMVVTVFVLCWMPFYV 273
Cdd:cd15318 157 SCQLLYNKLWGwlnfpvFFIPCLIMIGLYvkIFIVAKRQARAIASLLSDTNgasKRERKAAKTLGIAVGVYLLCWLPFTI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   274 VQLLNLFVTSLDATVNHVSLI-LSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15318 237 DTMVDSLLNFITPPLLFDIIIwFAYFNSACNPLIYVFSYPWFRKA 281
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
44-323 2.13e-20

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 89.88  E-value: 2.13e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15295   1 VVLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVgAISIPLYIPYTLTNRWDFGRGLCVFWLVID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHplrAATYR--RPSVAKLINL--GVWLASLLVTLPIAVFADTRPARGGEAVACNLHW 198
Cdd:cd15295  81 YLLCTASVYNIVLISYDRYQSVSN---AVSYRnqQTATLRIVTQmvAVWVLAFLVHGPAILVSDSWKTEDGECEPEFFSN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHpawsavFVIYTFLLGFLLPVLAIGLCYLLIVGKMRavalragwqqRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLN 278
Cdd:cd15295 158 WY------ILAITSVLEFLVPVILVAYFNTQIYWSLW----------KRLRDRKLAKSLAIILGTFAICWAPYSLFTIIR 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   279 LFV-TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLC 323
Cdd:cd15295 222 AACeKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIFC 267
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
46-318 2.24e-20

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 90.31  E-value: 2.24e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIyalVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFM-LSVPFVASAAALRHWPF-----GAVLCRAVL 119
Cdd:cd15975   6 LSCI---IFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIvIDIPINVYKLLAQKWPFddssfGVFLCKLVP 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   120 SVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRP--ARGGEAVACNLH 197
Cdd:cd15975  83 FLQKASVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPEAIGFVMVPfeYNGEQYRTCMLN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   198 wPHPAWSAVFV----IYTFLLGFLLPVLAIGLCYLLIVGKM---RAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMP 270
Cdd:cd15975 163 -ATTKFMNFYVdakdWWLFGFYFCVPLACTAIFYTLMTCEMlnrRKGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFP 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 469169   271 FYVVQLLNLFV-----------TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15975 242 LHLSRILKKTVynendprrcelLSFLLVMDYISINLATMNSCINPIALYFVSKKFKNCF 300
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
49-318 2.63e-20

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 89.36  E-value: 2.63e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15066   5 AMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAmTFNASVEITGRWMFGYFMCDVWNSLDVYFST 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPIAVFADTRParggEAVACNLHWPHPAWSAV 206
Cdd:cd15066  85 ASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISfLPIFLGWYTTE----EHLQYRKTHPDQCEFVV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFL---LGFLLPVLAIGLCYLLIvgkmravalragWQQRRRsEKKITRLVLMVVTVFVLCWMPF---YVVQLLNLF 280
Cdd:cd15066 161 NKIYALIsssVSFWIPCIVMIFTYYRI------------YLEAKR-EHKAAKTLGIIMGAFILCWLPFflwYVTTTLCGD 227
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   281 VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15066 228 ACPYPPILVSILFWIGYFNSTLNPLIYAYFNRDFREAF 265
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-318 2.96e-20

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 89.92  E-value: 2.96e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYA---KMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWP--FGAVLCRAVLSVD 122
Cdd:cd15356   6 VYALIWALGAAGNALTIHLVLKKRslrGLQGTVHYHLVSLALSDLLILLiSVPIELYNFVWFHYPwvFGDLVCRGYYFVR 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVF---------ADTRP---ARGGE 190
Cdd:cd15356  86 DICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFImgqkyeletADGEPepsSRVCT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   191 AVACNlhwphpAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRrsekkitrlvlMVVTVFVLCWMP 270
Cdd:cd15356 166 VLVSR------ATLKVFIQVNAFVSFVLPLALIAFLNGVTVSHLRIQSLQHSVQVLR-----------AIVIAYVICWLP 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 469169   271 FYVVQLLNLFVTSLDAT---------VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15356 229 YHARRLMFCYVPDDAWTdslynfyhyFYMLTNTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
44-318 3.25e-20

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 89.32  E-value: 3.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15300   1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIgIFSMNLYTSYILMGYWALGSLACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAV----FADTRPARGGEAVACNLHW 198
Cdd:cd15300  81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILcwqyFVGKRTVPERECQIQFLSE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PhpawsaVFVIYTFLLGFLLPVLAIGLCYLLIVgkmravalragwqQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLN 278
Cdd:cd15300 161 P------TITFGTAIAAFYIPVSVMTILYCRIY-------------KETIKERKAAQTLSAILLAFIITWTPYNIMVLVS 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   279 LFVTS-LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15300 222 TFCSDcIPLTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
44-318 4.17e-20

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 89.11  E-value: 4.17e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-ELFMLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15301   1 VLIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADfAIGVISMPLFTVYTALGYWPLGYEVCDTWLAID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP-IAVFADTRPARGGEAVACNLHWPHP 201
Cdd:cd15301  81 YLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPwIYSWPYIEGKRTVPAGTCYIQFLET 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFviYTFLLGFLLPVLAIGLCYLLIvgkmravaLRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15301 161 NPYVTF--GTALAAFYVPVTIMCILYWRI--------WRETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFF 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   282 TSLDATVNHV---SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15301 231 PCSDTIPTELwdfSYYLCYINSTINPLCYALCNAAFRRTY 270
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
41-318 5.15e-20

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 88.70  E-value: 5.15e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    41 AGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH-WPFGAVLCRAVL 119
Cdd:cd15333   2 GLKISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGtWTLGQVVCDIWL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   120 SVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFadtRPARGGEAVA-CNLHW 198
Cdd:cd15333  82 SSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFW---RQAKAEEEVSeCVVNT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHpawsAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAvalragwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLln 278
Cdd:cd15333 159 DH----ILYTVYSTVGAFYIPTLLLIALYGRIYVEARA------------RERKATKTLGIILGAFIVCWLPFFIISL-- 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   279 LFVTSLDATVNHVSLI-----LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15333 221 VLPICKDACWFHLAIFdfftwLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
49-318 5.78e-20

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 88.35  E-value: 5.78e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLV-----GNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVP--FVASAAALRHWPFGAVLCRAVLSV 121
Cdd:cd15308   1 AAALVGGVLLIlaiiaGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLplYVYSEFQGGVWTLSPVLCDALMTM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRaATYRRPSVAKLINLG-VWLASLLVTLPIAVFADTRPARggEAVACNLHwph 200
Cdd:cd15308  81 DVMLCTASIFNLCAISVDRFIAVSVPLN-YNRRQGSVRQLLLISaTWILSFAVASPVIFGLNNVPNR--DPAVCKLE--- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 pawSAVFVIYTFLLGFLLPvlaiglCYLLIVgkmravaLRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15308 155 ---DNNYVVYSSVCSFFIP------CPVMLV-------LYCAMFRGLGRERKAMRVLPVVVGAFLFCWTPFFVVHITRAL 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   281 VTSLDATVNHVSLI--LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15308 219 CESCSIPPQLISIVtwLGYVNSALNPVIYTVFNAEFRNVF 258
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
44-318 1.20e-19

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 88.47  E-value: 1.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKT-ATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAvLCRAVLSV 121
Cdd:cd15319   1 VVTGCLLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVmPWKAVAEVAGYWPFGA-FCDVWVAF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLpIAVFADTRPARGGEAVACNLHW--P 199
Cdd:cd15319  80 DIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISF-IPVQLNWHKDSGDDWVGLHNSSisR 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPA------WSAVFVIYTFLLGFLLPVLAIGLCYLLI-------VGKMRAVALRAGWQQRRRS----------------- 249
Cdd:cd15319 159 QVEencdssLNRTYAISSSLISFYIPVAIMIVTYTRIyriaqiqIRRISSLERAAEHAQSCRSnridchhhtslrtsikk 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   250 EKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTS-----------LDATVNHVSLILSYANSCANPILYGFLSDnFRRSF 318
Cdd:cd15319 239 ETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCDRppadpdaglpcVSETTFDVFVWFGWANSSLNPIIYAFNAD-FRKVF 317
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
44-318 1.25e-19

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 87.38  E-value: 1.25e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15298   1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIgAFSMNLYTVYIIKGYWPLGAVVCDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrpARGGEAVACNLHWPHPA 202
Cdd:cd15298  81 YVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQF--VVGKRTVPDNQCFIQFL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIvgkmravalragwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV- 281
Cdd:cd15298 159 SNPAVTFGTAIAAFYLPVVIMTVLYIHI-------------SLASARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCq 225
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   282 TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15298 226 SCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTF 262
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
49-318 1.32e-19

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 87.40  E-value: 1.32e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15309   6 LLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVaTLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPL----RAATYRRPSVAKLInlgVWLASLLVTLPIAVFADTRPARggeavACNLHWPhpaw 203
Cdd:cd15309  86 ASILNLCAISIDRYTAVAMPMlyntRYSSKRRVTVMISV---VWVLSFAISCPLLFGLNNTDQN-----ECIIANP---- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 saVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRavalragwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT- 282
Cdd:cd15309 154 --AFVVYSSIVSFYVPFIVTLLVYVQIYIVLQ-------------KEKKATQMLAIVLGVFIICWLPFFITHILNMHCDc 218
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   283 SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15309 219 NIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-318 1.37e-19

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 88.04  E-value: 1.37e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15977   6 LSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILiAIPINVIKLIAEDWPFGVHVCKLYPFIQKASVG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPsVAKLINLGV-WLASLLVTLPIAVFADTR--PARGGEAVACNLHWPHPA-- 202
Cdd:cd15977  86 ITVLSLCALSIDRYRAVASWSRIRGIGIP-VWKAVEVTLiWAVAIIVAVPEAIAFDMVeiDYRGQTLLVCMLPMEQTSsf 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 ---WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKM--RAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:cd15977 165 mrfYQDVKDWWLFGFYFCLPLACTGVFYTLMSCEMlsIKNGMRIALNDHMKQRREVAKTVFCLVVIFALCWLPLHLSRIL 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   278 NLFVT-----------SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15977 245 KKTIYdvkdpqrcellSFLLVMDYTGINMASLNSCINPVALYFVSRKFKNCF 296
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
49-315 1.62e-19

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 87.03  E-value: 1.62e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15072   6 ILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQAHGFQGFFTALA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATyrrpSVAKLINLGVWLASLL-VTLPIAVFA--DTRPARggeaVACNLHWPHPAWSa 205
Cdd:cd15072  86 SICSSAAIAWDRYHHYCTRSKLQW----STAISLVLFVWLFSAFwAAMPLLGWGeyDYEPLG----TCCTLDYSKGDRN- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 vFVIYTFLLG---FLLPVLAIGLCYLLIVGKMravalragwqqrrRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF-- 280
Cdd:cd15072 157 -YVSYLFTMAffnFILPLFILLTSYSSIEQKL-------------KKEGHLRFNTGLPLLTLLICWGPYAILALYAAItd 222
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   281 VTSLDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15072 223 VTSISPKLRMVPALLAKTSPTINAILYALGNENYR 257
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
46-315 2.41e-19

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 87.21  E-value: 2.41e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNAlVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:cd15149   3 IPVFYSLVFIVGILLNG-VNFWIFFYVPSNKSFIVYLKNIVFADLLMSLTFPFkILSDVELGPWQLNVIVCRYSAVIFYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADtRPARGGEAVAC-------NLH 197
Cdd:cd15149  82 NMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTN-QSFHEANYTKCarlkselGIQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   198 WpHPAWSAVFVIYTFLLGFLLPVLaiglcYLLIVGKMRAVALRAGwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL- 276
Cdd:cd15149 161 W-HKASNYICVSIFWVVFLLLIIF-----YVAISRKIYKSNQKFR-RNSTNMKAKSSRNIFSILFVFFVCFVPYHALRIp 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   277 LNLFVTSLDAT---------VNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15149 234 YTLSQTGADYScqsktilyyMKEFTLLLSAANVCLDPIIYFFLCQPFR 281
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
49-315 6.20e-19

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 85.97  E-value: 6.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15167   6 FYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVkIAVDLGIAPWKLKIFHCQVTACLIYINMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP-IAVFADTRPARGGeaVAC-------NLHWp 199
Cdd:cd15167  86 LSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPnMAIPIKTIEEKPG--VGCadfktefGRHW- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 hpawsavFVIYTFLlgfllpVLAIGLCYLLIVGKMRAVALRAGWQQR----RRSEKKITRLVLMVVTVFVLCWMPFYVVQ 275
Cdd:cd15167 163 -------HVLTNFI------CMAIFLNFSAIILISNFLVIRKLYRNKdseeYRNARQALVNILLVTAGYVICFVPYHIVR 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   276 LLNLFVTS---LDATVNHV-------SLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15167 230 IPYTLSQSeviTDCSLKRSlflakesTLLLAVLNLCFDPILYFHLSKAFR 279
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
44-318 8.31e-19

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 85.10  E-value: 8.31e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15331   1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVaVLVMPLSAVYEVSQHWFLGPEVCDMWISMD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHplraATYRRPSVAKLINLG---VWLASLLVTLPiAVFADTRPArggeavacnlHWP 199
Cdd:cd15331  81 VLCCTASILHLVAIALDRYWAVTN----IDYIRRRTAKRILIMiavVWFVSLIISIA-PLFGWKDED----------DLD 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAV--------FVIYTFLLGFLLPVLAIGLCYLLIvgkmravalragWQQRRRsEKKITRLVLMVVTVFVLCWMPF 271
Cdd:cd15331 146 RVLKTGVclisqdygYTIFSTVGAFYVPLLLMIIIYWKI------------YQAAKR-ERKAARTLAIITGAFVVCWLPF 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   272 YVVQLLNLFVTSLD--ATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15331 213 FLVALVMPFCGAWQisRFLESFFLWLGYFNSLLNPIIYTIFSPDFRGAF 261
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
49-311 8.68e-19

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 86.03  E-value: 8.68e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD---ELFMLSVPFVASAAALRHWPFGavLCRAVLSVDGLN 125
Cdd:cd15385   6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADlvvAFFQVLPQLCWDITYRFYGPDF--LCRIVKHLQVLG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRaaTYRRPSV-AKLINLGVWLASLLVTLP-IAVFADTRPARGGEAVACNLHWPHPAW 203
Cdd:cd15385  84 MFASTYMLVMMTADRYIAICHPLK--TLQQPTKrSYLMIGSAWALSFILSTPqYFIFSLSEIENGSGVYDCWANFIVPWG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKM-RAVALRAGWQQRRRSEKKIT-------------------RLVLMVVTV 263
Cdd:cd15385 162 IKAYITWITISIFVVPVIILLTCYGFICYNIwRNIKCKTRRGLSDNALKNILlavcvssvktisrakirtvKMTFVIVLA 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 469169   264 FVLCWMPFYVVQLLNLF------VTSLDATVNhVSLILSYANSCANPILYGFLS 311
Cdd:cd15385 242 YIVCWAPFFTIQMWSVWdqnfpwDESENTAVT-ITALLASLNSCCNPWIYMFFS 294
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
49-315 8.91e-19

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 85.21  E-value: 8.91e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15398   6 LYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLfCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLraATYRRPSVAKLINLGVWLASLLVTLPIAVF---ADTRPARGGEAVA----CNLHWPH 200
Cdd:cd15398  86 VSTLMLMSIAIVRYHMIKHPL--SNHLTANHGYFLLGTVWTLGFTICSPLPVFhkiVDLSETFNLESLKnkylCIESWPS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMravalragwqqrRRSEKKITRLVLmVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15398 164 DSYRIAFTISLLFVQYILPLVCLTVSHTSVCRSV------------KRSRSVFYRLTI-VILAFAVSWMPLHLFHLVTDF 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   281 VTSLDATvNHVSLI------LSYANSCANPILYGFLSDNFR 315
Cdd:cd15398 231 NANLISN-RHFKLVycichlLGMLSCCLNPILYGFLNNGIK 270
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
46-318 9.20e-19

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 85.42  E-value: 9.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-----FMLSVPFVASAAALRHWPFGAVLCRAVLS 120
Cdd:cd14972   1 VLVVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLagiafVFTFLSVLLVSLTPSPATWLLRKGSLVLS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   121 vdglnMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLV-TLPIAVFADTRPARGGeavaCNLHWP 199
Cdd:cd14972  81 -----LLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLaLLPVLGWNCVLCDQES----CSPLGP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAVFVIYTFllgFLLPVLAIGLCYL--LIVGKMRAVALRAGWQQRRRSEKKITR----LVLMVVTVFVLCWMPFYV 273
Cdd:cd14972 152 GLPKSYLVLILVF---FFIALVIIVFLYVriFWCLWRHANAIAARQEAAVPAQPSTSRklakTVVIVLGVFLVCWLPLLI 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   274 VQLLNLFVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd14972 229 LLVLDVLCPSvcDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
55-318 1.10e-18

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 85.35  E-value: 1.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADeLFMLSVPFVASAAALRH--WPFGAVLCRAVLSVDGLNMFTSVFC 132
Cdd:cd15401  12 VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVAD-LVVAVYPYPLILLAIFHngWTLGNIHCQISGFLMGLSVIGSVFN 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   133 LTVLSVDRYVAVVHPLR-AATYRRPSVAKLINLgVWLASLLVTLPiaVFADTRPARGGEAVACNLhwpHPAWSAVFVIYT 211
Cdd:cd15401  91 ITAIAINRYCYICHSLRyDKLYNMKKTCCYVCL-TWVLTLAAIVP--NFFVGSLQYDPRIYSCTF---AQTVSSSYTITV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   212 FLLGFLLPVLAIGLCYLLIVGKMRAVA--LRAGWQQRRRSEKKITRLVLMVVTV-FVLCWMPfyvvqlLNLFVTSLDATV 288
Cdd:cd15401 165 VVVHFIVPLSIVTFCYLRIWVLVIQVKhrVRQDSKQKLKANDIRNFLTMFVVFVlFAVCWGP------LNFIGLAVAINP 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   289 NHV-----------SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15401 239 LKVapkipewlfvlSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
61-317 1.12e-18

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 85.29  E-value: 1.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    61 NALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCraVLSVDGLNMF--TSVFCLTVLS 137
Cdd:cd15085  18 NVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALcGTTIVTVTNYEGYFYLGDAFC--IFQGFAVNYFgiVSLWSLTLLA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   138 VDRYVAVVHPLRAATYRRPSVAKLINLgVWLASLL-VTLPIAVFADTRPArgGEAVACNLHWPHPAWSAV-FVIYTFLLG 215
Cdd:cd15085  96 YERYNVVCKPMGGLKLSTKRGYQGLLF-IWLFCLFwAVAPLFGWSSYGPE--GVQTSCSIGWEERSWSNYsYLILYFLMC 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   216 FLLPVLAIGLCYLLIVGKMRAVALRA---GWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL-----NLFVTSLDAT 287
Cdd:cd15085 173 FVIPVAIIGFSYGNVLRSLHKLNKKIeqqGGKNCPEEEERAVIMVLAMVIAFLICWLPYTVFALIvvvnpELSISPLAAT 252
                       250       260       270
                ....*....|....*....|....*....|
gi 469169   288 vnhVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15085 253 ---MPTYFAKTSPVYNPIIYIFLNKQFRES 279
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
55-318 2.82e-18

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 84.13  E-value: 2.82e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCL 133
Cdd:cd15400  12 VVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALyPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   134 TVLSVDRYVAVVHPLR-AATYRRPSVAKLINLgVWLASLLVTLPiaVFADTRPARGGEAVACNLhwpHPAWSAVFVIYTF 212
Cdd:cd15400  92 TGIAINRYCYICHSFAyDKLYSRWNTLLYVCL-IWALTVVAIVP--NFFVGSLEYDPRIYSCTF---VQTASSSYTIAVV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   213 LLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVL---CWMPFYVVQLL-----NLFVTSL 284
Cdd:cd15400 166 VIHFIVPITVVSFCYLRIWVLVIQVRRKVKSESKPRLKPSDFRNFLTMFVVFVIfaiCWAPLNLIGLAvainpQEMAPKV 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 469169   285 DATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15400 246 PEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
52-317 2.97e-18

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 83.66  E-value: 2.97e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKT-ATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15219   8 VVLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLtVLNMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLlvTLPIAVFADTRPARGGEAVACNLHWPHPAWS---AV 206
Cdd:cd15219  88 MLSMAALSIDRWIAVVFPLSYTSKMRYRDAALMVGYSWLHSL--TFSLVALFLSWLGYSSLYASCTLHLPREEERrrfAV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPvLAIGLCYLLIVGKMRavalragwqQRRRSEKKITrlvlMVVTVFVLCWMPFYVVQLLNLFVTsldA 286
Cdd:cd15219 166 FTAFFHAFTFLLS-LLVLCVTYLKVLKVR---------RRQRATKKIS----IFIGTFVLCFAPYVITRLVELLPF---V 228
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   287 TVNH----VSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15219 229 TINRywgiVSKCLTYSKAASDPFVYSLLRQQYRKV 263
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
53-316 3.11e-18

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 83.79  E-value: 3.11e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    53 VCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVAS------------AAALRHwpfgAVLCR---- 116
Cdd:cd15137  10 VGIIALLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLLIIASvdlyyrgvyikhDEEWRS----SWLCTfagf 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   117 -AVLSVDglnmfTSVFCLTVLSVDRYVAVVHPLRAATYRRpSVAKLINLGVWLASLLVT----LPIAVFADTRpARGGEA 191
Cdd:cd15137  86 lATLSSE-----VSVLILTLITLDRFICIVFPFSGRRLGL-RRAIIVLACIWLIGLLLAvlplLPWDYFGNFY-GRSGVC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   192 VACNLHWPHPA-W--SAVFVIYTFLLGFLLpvlaIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFvLCW 268
Cdd:cd15137 159 LPLHITDERPAgWeySVFVFLGLNFLAFVF----ILLSYIAMFISIRRTRKAAASRKSKRDMAVAKRFFLIVLTDF-LCW 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 469169   269 MPFYVVQLLNLFVTSLDATVnhvslilsYA---------NSCANPILYGFLSDNFRR 316
Cdd:cd15137 234 IPIIVIGILALSGVPIPGEV--------YAwvavfvlpiNSALNPILYTLSTPKFRK 282
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
52-315 3.77e-18

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 83.73  E-value: 3.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADeLFMLSVPFVASAAALRH--WPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15080   9 LLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVAD-LFMVFGGFTTTMYTSMHgyFVFGPTGCNLEGFFATLGGEIA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLraATYRRPSVAKLINLG-VWLASLLVTLPiAVFADTRPARGGEAVACNLHW--PHPAW-SA 205
Cdd:cd15080  88 LWSLVVLAIERYVVVCKPM--SNFRFGENHAIMGVAfTWVMALACAAP-PLVGWSRYIPEGMQCSCGIDYytLKPEVnNE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYllivGKMRAVALRAGWQQR-----RRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15080 165 SFVIYMFVVHFTIPLIVIFFCY----GRLVCTVKEAAAQQQesattQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFT 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   281 VTSLDATVNHVSLILSYANSCA--NPILYGFLSDNFR 315
Cdd:cd15080 241 HQGSDFGPIFMTIPAFFAKSSAvyNPVIYILMNKQFR 277
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
42-318 4.46e-18

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 83.58  E-value: 4.46e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    42 GMVTIQCIYALVCLVGlvgNALVIFVILRYAKMK-TATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVL 119
Cdd:cd15104   1 AAGVILAVLSPLIITG---NLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSdGENTQKVLCLLRM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   120 SVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPIAVFADTRPARGGEavaCNLHW 198
Cdd:cd15104  78 CFVITSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGfLPLISPQFQQTSYKGK---CSFFA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 P-HPAwsavFVIYTFLLGFLLPVLAIGLCYLLI----------VGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLC 267
Cdd:cd15104 155 AfHPR----VLLVLSCMVFFPALLLFVFCYCDIlkiarvhsraIYKVEHALARQIHPRRTLSDFKAARTVAVLIGCFLLS 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 469169   268 WMPFYVVQLLNLFVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15104 231 WLPFQITGLVQALCDEckLYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
51-315 7.82e-18

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 82.50  E-value: 7.82e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTAtnIYLLNLAVADEL---FMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15220   7 VLLDLTALVGNTAVMVVIAKTPHLRKF--AFVCHLCVVDLLaalLLMPLGILSSSPFFLGVVFGEAECRVYIFLSVCLVS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLpIAVFADTRPARGGEAVA--CNLHWPHPAWSA 205
Cdd:cd15220  85 ASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGL-LPVLGWPSYGGPAPIAArhCSLHWSHSGHRG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAI----GLCYLLIVGKMRAVALragwqqrrrsekkitrlvLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15220 164 VFVVLFALVCFLLPLLLIlvvyCGVFKVFGGGKAALTL------------------AAIVGQFLCCWLPYFAFHLYSALA 225
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   282 TSLDAT--VNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15220 226 ASPVSGgeAEEVVTWLAYSCFAVNPFFYGLLNRQIR 261
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
52-318 8.84e-18

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 82.68  E-value: 8.84e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVdgLNMFTSV 130
Cdd:cd15068   9 AIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVgVLAIPFAITISTGFCAACHGCLFIACFVL--VLTQSSI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL-PIAVFADTRPARGGEAVACNLhwPHPAWSAVF-- 207
Cdd:cd15068  87 FSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLtPMLGWNNCGQPKEGKNHSQGC--GEGQVACLFed 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 -------VIYTFLLGFLLPVLAIGLCYLLIV----GKMRAVALRAGWQQRRRS----EKKITRLVLMVVTVFVLCWMPFY 272
Cdd:cd15068 165 vvpmnymVYFNFFACVLVPLLLMLGVYLRIFlaarRQLKQMESQPLPGERARStlqkEVHAAKSLAIIVGLFALCWLPLH 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   273 VVQLLNLFVTSLD---ATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15068 245 IINCFTFFCPDCShapLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTF 293
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
44-323 9.84e-18

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 82.60  E-value: 9.84e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL---FMLSVPFVASAAALrhWPFGAVLCRAVLS 120
Cdd:cd15084  11 LTVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLvtlFGSSVSFSNNIVGF--FVFGKTMCEFEGF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   121 VDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSvAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHW-P 199
Cdd:cd15084  89 MVSLTGIVGLWSLAILAFERYLVICKPMGDFRFQQRH-AVSGCAFTWGWSLLWTSP-PLFGWSSYVPEGLRTSCGPNWyT 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQ-RRRSEKKITRLVLMVVTVFVLCWMP---FYVVQ 275
Cdd:cd15084 167 GGTNNNSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKESEtTQRAEKEVTRMVIAMVMAFLICWLPyatFAMVV 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   276 LLNLFVtSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLC 323
Cdd:cd15084 247 ATNKDV-VIQPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCLLELLC 293
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
52-318 4.17e-17

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 80.34  E-value: 4.17e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-----ELFMLSVPFVASAAALRH----WPFGAvLCR-----A 117
Cdd:cd15136   9 FVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADfcmgiYLGLLAIVDAKTLGEYYNyaidWQTGA-GCKtagflA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   118 VLSVDglnmfTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLV-TLPIAVFADTRparggeAVACNL 196
Cdd:cd15136  88 VFSSE-----LSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMaLLPLVGVSSYS------KTSICL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   197 hwPHPAWSAVFVIY-TFLLGF-LLPVLAIGLCYLLIVgkmraVALRAGWQQRRRSEKKIT-RLVLMVVTVFvLCWMPFYV 273
Cdd:cd15136 157 --PFETETPVSKAYvIFLLLFnGLAFLIICGCYIKIY-----LSVRGSGRAANSNDTRIAkRMALLVFTDF-LCWAPIAF 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   274 VQLLNLFVTSL-DATVNHVSLILSYA-NSCANPILYGFLSDNFRRSF 318
Cdd:cd15136 229 FGLTAAFGLPLiSVSNAKILLVFFYPlNSCANPFLYAIFTKQFRRDC 275
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
48-318 7.06e-17

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 80.23  E-value: 7.06e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPF-GAVLCraVLSVDGLNM 126
Cdd:cd15082  18 ALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFlGVWAC--VLEGFAVTF 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 F--TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInLGVWLASLLVTLPIAV-FADTRPARGGeaVACNLHWPHPAW 203
Cdd:cd15082  96 FgiVALWSLAVLAFERFFVICRPLGNIRLQGKHAALGL-LFVWTFSFIWTIPPVLgWSSYTVSKIG--TTCEPNWYSGNM 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 S-AVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVA-LRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLnlfV 281
Cdd:cd15082 173 HdHTYIITFFTTCFILPLGVIFVSYGKLLQKLRKVSnTQGRLGNARKPERQVTRMVVVMIVAFMVCWTPYAAFSIL---V 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   282 TS-----LDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15082 250 TAhptihLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
44-317 8.83e-17

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 79.89  E-value: 8.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-ELFMLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15403   1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDiMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRpsvAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHWPHPA 202
Cdd:cd15403  81 WFFVLEGVAILLIISVDRFLIIVQRQDKLNPHR---AKVMIAISWVLSFCISFP-SVVGWTLVEVPARAPQCVLGYTESP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTV------------------- 263
Cdd:cd15403 157 ADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNAVRIHNHADSLCLSQVSKLGLMGLQRphqmnvdmsfktrafttil 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 469169   264 -----FVLCWMPFYVVQLLNLF-----VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15403 237 ilfvgFSLCWLPHTVFSLLSVFsrrfyYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFREA 300
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
44-318 1.33e-16

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 79.02  E-value: 1.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPF-VASAAALRHWPFGAVLCRAVLSV 121
Cdd:cd15302   1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIgLESMPFyTVYVLNGDYWPLGWVLCDLWLSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVtLPIAVFA------DTRPARGGEAVACN 195
Cdd:cd15302  81 DYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALL-FFISIFGwqyftgQGRSLPEGECYVQF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   196 LHWPHpawsavfviytFLLGFLLPVLAIGLCYLLIvgkmravaLRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQ 275
Cdd:cd15302 160 MTDPY-----------FNMGMYIGYYWTTLIVMLI--------LYAGIYRAANRARKALRTITFILGAFVICWTPYHILA 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   276 LLNLFVTSLDATVNH---VSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15302 221 TIYGFCEAPPCVNETlytISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
48-316 1.64e-16

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 79.05  E-value: 1.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATnIYLLNLAVADELFMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15151   5 VLYTVLFLVGLILNSVAAWIFFHIPSTSTFI-VYLKNTLVADLIMTLMLPFkILSDSGLGPWQLRAFVCRFSAVVFYITM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADtRPARGGEAVAC-NLHWPHPAWSA 205
Cdd:cd15151  84 YISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSN-KPATPISVKKCaSLKSPLGLKWH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAvALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL---LNLFVT 282
Cdd:cd15151 163 EVVNYICQFIFWGVFALMVLFYTIISKKVYE-SYKKSRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFVRVpytLSQTGK 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   283 SLDATVNH-------VSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15151 242 ITDCQLQNllyiakeITLWLAATNVCLDPLIYIFLCKSFRQ 282
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
49-313 1.93e-16

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 78.66  E-value: 1.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLvglvGNALVIFVILRYAKMKTATNIYLLNLAVADEL-FMLSVPF-VASAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15212  10 IFLLSSL----GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLtALLCLPFaFLTLFSRPGWLFGDRLCLANGFFNACFG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLinLGVWLASLLVTLPIAVFADTRP---ARGGEAVACNLHWPHPAW 203
Cdd:cd15212  86 IVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQLL--AAAWLTALGFSLPWYLLASAPEyyeKLGFYHCLYVLHSGPSRL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRA------GWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:cd15212 164 GAAYSSVLIVLCYLLPFALMCFCHYNICKTVRLSESRVrpvttyAHLLRFYSEMRTATTVLIMIVFIICCWGPYCLLGLV 243
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   278 -NLFVTSLDATVNHVSLILSYANSCANPILYGFLSDN 313
Cdd:cd15212 244 aAAGGYQFPPLMDTVAIWMAWANGAINPLIYAIRNPN 280
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
49-320 3.68e-16

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 77.86  E-value: 3.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATN-IYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCravlSVDGLNMF 127
Cdd:cd14983   6 VYVLTILLGLPSNLLALYAFVNRARLRLTPNvIYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLC----PLYNLAHF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFC----LTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLAS-----LLVTLPIAVFADTRPARGGEAVACNLHW 198
Cdd:cd14983  82 STLYAstcfLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVifhvtLVFILETSGGTLDINTPVGNSSTCYENF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PhPAWSAVFVIYTF---LLGFLLPVLAIGLCYlliVGKMRAVALRAGWQQRRRsekKITRLVLMVVTVFVLCWMPFYVVQ 275
Cdd:cd14983 162 T-PEQLALLAPVRLelsLVLFFLPLAITAFCY---VRCIRILVRSRLHERRKR---RAVRVAVSTLLTFVVCFGPYNISH 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   276 LLNlFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQR 320
Cdd:cd14983 235 VVG-FVRHESVWWRKLALLTSTCNAFLDPLIFYFLSSSMERGFVH 278
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
52-318 3.77e-16

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 78.65  E-value: 3.77e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAALRH-WPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15005   9 LILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLAcFPFVMASVRHGSgWIYGALSCKVIAFLAVLFCFHS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNL-HWPHPAWSAvfv 208
Cdd:cd15005  89 AFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFP-PVFDVGTYTFIREEDQCTFeHRSYKANDT--- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   209 iYTFLLGFLLPVLAIGLCYLLIV------GKMRAVAL-------------------RAGW-------------------- 243
Cdd:cd15005 165 -LGFMLVLAVVIAATHLVYLKLLiflrhhRKMKPAQLvpaisqnwtfhgpgatgqaAANWtagfgrgptpptllgirqaf 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   244 -QQRRRS--------EKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTslDATVNHV----SLILSYANSCANPILYGFL 310
Cdd:cd15005 244 hSGARRLlvldefkmEKRLTRMFYAITLLFLLLWSPYIVACYIRVFVR--GYAVPQGfltaAVWMTFAQAGVNPIVCFFF 321

                ....*...
gi 469169   311 SDNFRRSF 318
Cdd:cd15005 322 NRELRKCL 329
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
44-316 5.03e-16

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 77.51  E-value: 5.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelfmLSVPFVASAA-----ALRHWPFGAVLCraV 118
Cdd:cd15075   1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVAD----LGTTVFGGLLsvvtnAVGYFNLGRVGC--V 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   119 LSVDGLNMF--TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGvWLASLLVTLPiAVFADTRPARGGEAVACNL 196
Cdd:cd15075  75 LEGFAVAFFgiAALCTVAVIAVDRLFVVCKPLGTLTFQTRHALAGIASS-WLWSLIWNTP-PLFGWGSYQLEGVMTSCAP 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   197 HW----PHpawSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQ--RRRSEKKITRLVLMVVTVFVLCWMP 270
Cdd:cd15075 153 DWysrdPV---NVSYILCYFSFCFAIPFAIILVSYGYLLWTLRQVAKLGVAEGgsTAKAEVQVARMVVVMVMAFLLCWLP 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   271 FYVVQLLNLFVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15075 230 YAAFALTVVSKPDvyINPLIATVPMYLAKSSTVYNPIIYIFMNKQFRD 277
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
52-318 5.50e-16

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 77.56  E-value: 5.50e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRHWPFGA-----VLCRAVLSVDGLN 125
Cdd:cd15128   9 LIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIViDLPINVYKLLAMDWPFGDqpfgqFLCKLVPFIQKAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPA--RGGEAVACNLHwPHPAW 203
Cdd:cd15128  89 VGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFnyKGVTLRTCLLR-PETSF 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVI----YTFLLGFLLPVLAIGLCYLLIVGKM---RAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL 276
Cdd:cd15128 168 MKFYIDvkdwWLFGFYFCLPLVCTAIFYTLMTCEMlrkRNGMLRIALNEHLKQRREVAKTVFCLVVIFALCWLPLHLSRI 247
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 469169   277 LNLFV-----------TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15128 248 LKLTVydqndpnrcelLSFLLVLDYFGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
44-318 7.95e-16

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 76.75  E-value: 7.95e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-----FMLSVPFVASAaalrHWPFGAVLCRAV 118
Cdd:cd15296   1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLvggfcIPLYIPYVLTG----RWKFGRGLCKLW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   119 LSVDGLNMFTSVFCLTVLSVDRYVAVVhplRAATYR------RPSVAKLINlgVWLASLLVTLPIAVFADTrpARGGEAV 192
Cdd:cd15296  77 LVVDYLLCTASVFNIVLISYDRFLSVT---RAVSYRaqkgmtRQAVLKMVL--VWVLAFLLYGPAIISWEY--IAGGSII 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   193 ACNLHWPHPAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGwqqrrrSEKKITRLVLMVVTVFVLCWMPFY 272
Cdd:cd15296 150 PEGECYAEFFYNWYFLMTASTLEFFTPFISVTYFNLSIYLNIQKRRFRLS------RDKKVAKSLAIIVCVFGLCWAPYT 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   273 VVQLLNLFV--TSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15296 224 LLMIIRAAChgHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
44-315 8.90e-16

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 76.42  E-value: 8.90e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15404   1 VILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLaVLNMPFALVTIITTRWIFGDAFCRVSAMFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVhplRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTR--PARggeAVACNLHWPH 200
Cdd:cd15404  81 WLFVMEGVAILLIISIDRFLIIV---QKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLqiPSR---APQCVFGYTT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAgwqqrrrsekkiTRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15404 155 NPGYQAYVILIMLIFFFIPFMVMLYSFMGILNTVRSFKTRA------------FTTILILFIVFTVCWAPFTTYSLVATF 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   281 VTSLDATVNHVS-----LILSYANSCANPILYGFLSDNFR 315
Cdd:cd15404 223 NSHFYHKHNFFEistwlLWLCYLKSALNPLIYYWRIKKFR 262
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
52-318 1.22e-15

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 76.51  E-value: 1.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-ELFMLSVPFVASAAALRHWPFGAVLCRAVLSVdgLNMFTSV 130
Cdd:cd15069   9 IIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADvAVGLFAIPFAITISLGFCTDFHSCLFLACFVL--VLTQSSI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP---------IAVFADTRPARGGEAVACNL--HWP 199
Cdd:cd15069  87 FSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTpflgwnkamSATNNSTNPADHGTNHSCCLisCLF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HPAWSAVFVIYTFLLGFLLPVLAIGL-----CYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVV 274
Cdd:cd15069 167 ENVVPMSYMVYFNFFGCVLPPLLIMLviyikIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCWLPVHIL 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   275 QLLNLFVTSLDAT----VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15069 247 NCITLFQPEFSKSkpkwAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-311 1.36e-15

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 76.39  E-value: 1.36e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD---ELFMLSVPFVASAAALRHWPfgAVLCRAVLSVDGLN 125
Cdd:cd15387   6 VLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADlvvAVFQVLPQLIWDITFRFYGP--DFLCRLVKYLQVVG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINlgvWLASLLVTLP-IAVFADTRPARGgeAVACNLHWPHPAWS 204
Cdd:cd15387  84 MFASTYMLLLMSIDRCLAICQPLRSLHRRSDRVYVLFS---WLLSLVFSIPqVHIFSLREVGNG--VYDCWADFIQPWGP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLLGFLLPVLAIGLCYLLIVGKM---------RAVALRAGWQQRRR------------SEKKIT--RLVLMVV 261
Cdd:cd15387 159 KAYITWITLSVYIIPVLILSVCYGLISFKIwqnvklktrRETKTPLSSAASGGaalarvssvkliSKAKIRtvKMTFVIV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   262 TVFVLCWMPFYVVQLLNLFVTSL--DATVNHVSLILSYANSCANPILYGFLS 311
Cdd:cd15387 239 LAYIVCWTPFFFVQMWSVWDPNApkEASPFIIAMLLASLNSCCNPWIYMFFT 290
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
52-315 1.59e-15

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 76.01  E-value: 1.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSV 130
Cdd:cd15076   9 FVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFcIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHPLraATYRRPSVAKLINLG-VWLASLLVTLPiAVFADTRPARGGEAVACNLHWPHPAW---SAV 206
Cdd:cd15076  89 WSLAFLAFERYIVICKPF--GNFRFGSKHALGAVVaTWIIGIGVSLP-PFFGWSRYIPEGLQCSCGPDWYTVGTkyrSEY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRagwQQR----RRSEKKITRLVLMVVTVFVLCWMPFYVVQLlnLFVT 282
Cdd:cd15076 166 YTWFLFIFCFIVPLSIIIFSYSQLLGALRAVAAQ---QQEsastQKAEREVSRMVVVMVGSFCLCYVPYAALAM--YMVN 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   283 S----LDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15076 241 NrdhgLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFR 277
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
44-318 2.83e-15

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 75.99  E-value: 2.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFV---ILRYAKMKTATNIYLLNLAVADEL-FMLSVP--FVASAAALRHWPFGAVLCRA 117
Cdd:cd15135   1 ITLTLLYSLILVAGILGNSATIKVtqvLQKKGYLQKSVTDHMVSLACSDLLvLLLGMPveLYSAIWDPFATPSGNIACKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   118 VLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInLGVWLASLLVTLP-------------IAVFADTR 184
Cdd:cd15135  81 YNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLI-CFVWLTSALVALPllfamgtedpleaFPSYRGTR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   185 PARGGEA----VACNL--HWPhpawsaVFV--IYTFLLGFLLPVLAIG-LCY----LLIVGKMRAVALRAGW---QQRRR 248
Cdd:cd15135 160 HHCQDQKsnltICTSLssKWT------VFQasIFSAFVLYLLVLASVAfMCRrmmrALMGSKKGAVAVKGPGgsvQLLRK 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   249 S---EKKITR------LVLMVVTVFVlCWMPFYVVQLLNLFVTSLDATVNH---------VSLILSYANSCANPILYGFL 310
Cdd:cd15135 234 HesaEGKTARkqtilfLGLIVGTLAV-CWMPNQIRRIMAAAKPKDDWTRSYfrayiillpIADTFFYLSSVLNPLLYNLS 312

                ....*...
gi 469169   311 SDNFRRSF 318
Cdd:cd15135 313 SQQFRSVF 320
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
50-317 3.22e-15

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 75.20  E-value: 3.22e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYA-KMKTATNIYLLNLAVAD---ELFMLSVPFVASAAALrHWPFGAVLCRAVLSVDGLN 125
Cdd:cd15129   7 YSVLLCLGLPVNILTAVALSRLAvRTKKSSYYYLLALTASDiltQVFIIFVGFILQTAIL-AREVPHALIHTVSVLEFAA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPI----AVFADTRPARGGEAVacnLHWPHp 201
Cdd:cd15129  86 NHASIWITVLLTVDRYVALCHPLRYRAVSYPERTRRIIAAVFVAALATGIPFywwsDMWRDSHPPTTLDKV---LKWTH- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 awsaVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGwqqrrrsekKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15129 162 ----CFIIYFIPCTIFLVTNSVIIHKLRRRKGRSGPQRRSG---------KTTAILLAITTVFAVLWAPRTVVIIYHLYV 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   282 TSL--DATVnHVSL----ILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15129 229 SSVnrDWRV-HLALdlanMLAMLNTAVNFFLYCFVSKRFRRT 269
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
44-318 4.00e-15

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 74.60  E-value: 4.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFM-LSVPF-VASAAALRHWPFGAVLCRAVLSV 121
Cdd:cd15328   1 VLVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAaLVMPLsLVHELSGRRWQLGRSLCQVWISF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFAdtrparGGEAVACNLHWPHP 201
Cdd:cd15328  81 DVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFG------WGETYSEDSEECQV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPvlaigLCYLLIV-GKMRAVAlragwqqrrRSEKKITRLVLMVVTVFVLCWMPFYVVQLLN-L 279
Cdd:cd15328 155 SQEPSYTVFSTFGAFYLP-----LCVVLFVyWKIYKAA---------QKEKRAALMVGILIGVFVLCWIPFFLTELISpL 220
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   280 FVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15328 221 CSCDIPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAF 259
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
44-317 5.23e-15

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 74.90  E-value: 5.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15316   1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVmPFSTVRSVESCWYFGESFCTFHTCCD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLlvTLPIAVFADTRPARGGEAVACNLHWPHPA 202
Cdd:cd15316  81 VSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSL--TYSFSVFYTGVNDDGLEELVNALNCVGGC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAV---FVIYTFLLgFLLPVLAIGLCY--LLIVGKMRAVALRAGWQQRRRS-----------EKKITRLVLMVVTVFVL 266
Cdd:cd15316 159 QIILnqnWVLVDFLL-FFIPTFAMIILYgkIFLVAKQQARKIEMTSSKAESSsesykdrvarrERKAAKTLGITVIAFLV 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   267 CWMPFYVVQLLNLFVTSL-DATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15316 238 SWLPYLIDVLIDAFMNFItPPYIYEICCWCAYYNSAMNPLIYALFYPWFRKA 289
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
52-322 7.20e-15

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 73.97  E-value: 7.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATnIYLLNLAVADELFMLSVpFVASAAALRHWPFG------AVLCRAVLSVDGLN 125
Cdd:cd15110   9 IICLLGLVGNGIVLWFLGFRIRRNPFT-VYILHLAIADFTFLLCI-FILSIMYIGPFNFShsrdyvAMLIFIILFLFGYN 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 mfTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTlpiavfadtrparGGEAVACNLHWPHPAWSA 205
Cdd:cd15110  87 --TGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLMT-------------SLEYLMCIDEGFHVRNEC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFV-IYTFLLGFLL--PVLAIGLCYLLIvgkmravALRAGWQQRRRSekKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd15110 152 RAVlIFIGILTFLVftPLMLISSLILFI-------KVRCNSQRRHPG--KLYIIIMLTVIFFLIFAMPMRVLLLLNYLHH 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   283 SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVL 322
Cdd:cd15110 223 SSFLFSNPVPFLLSTVNSSINPIVYFLVGSLRRKRIKKSL 262
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
51-318 9.18e-15

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 73.68  E-value: 9.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV-PFVASAAALRHWPFGAVLCRAVLSVDGLNMFTS 129
Cdd:cd15054   8 CLIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVmPPAMLNALYGRWVLARDFCPIWYAFDVMCCSAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVW-LASLLVTLPIAV------FADTRP--ARGGEAVACNLHWPH 200
Cdd:cd15054  88 ILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWtLAALASFLPIELgwhelgHERTLPnlTSGTVEGQCRLLVSL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PawsavFVIYTFLLGFLLPVLAIGLCYLLIvgkmravaLRAGwqqrrRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15054 168 P-----YALVASCLTFFLPSGAICFTYCRI--------LLAA-----RKALKASLTLGILLGMFFVTWLPFFVANVVQAV 229
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   281 VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15054 230 CDCVSPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
55-316 1.57e-14

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 73.30  E-value: 1.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAL--RHWPFGAVLCRAVLSVDGLNMFTSVFC 132
Cdd:cd15198  12 VAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSQIIWELlgDRWMAGDVACRLLKLLQASARGASANL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   133 LTVLSVDRYVAVVHPLRaatyRRPSVAKLINLGvWLASLLVTLPIA----VFADTRPARGGEAVAC--NLHWPHPAWS-A 205
Cdd:cd15198  92 VVLLALDRHQAIRAPLG----QPLRAWKLAALG-WLLALLLALPQAyvfrVDFPDDPASAWPGHTLcrGIFAPLPRWHlQ 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKM-----RAVALRAGWQQRR-------------RSEKKITRLVLMVVTVFVLC 267
Cdd:cd15198 167 VYATYEAVVGFVAPVVILGVCYGRLLLKWweranQAPGAKKPWKKPSkshlratapsalpRAKVKTLKMTLVIALLFVGC 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 469169   268 WMPFYVVQLLNLFVTS--LDATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15198 247 SLPYFIAELAAAFGSGdwEPEKVAAALGVMAVANSATNPFVFLFFNAGDCR 297
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
50-315 2.54e-14

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 72.24  E-value: 2.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRY-AKMKTATNIYLLNLAVADELFMLSVPFVASAAA--LRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15919   7 YSLLLCLGLPANILTVIILSQLvARRQKSSYNYLLALAAADILVLFFIVFVDFLLEdfILNKQMPQVLDKIIEVLEFSSI 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHwphpAWSAV 206
Cdd:cd15919  87 HTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWIEDYTSTSMHHVL----IWIHC 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYtfllgfLLPVLAIGLCYLLIVGKMRAvalRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDA 286
Cdd:cd15919 163 FTVY------LVPCSIFFVLNSIIVYKLRR---KSNFRLRGYSTGKTTAILFTITSIFAILWAPRIIMILYHLYVSPINN 233
                       250       260       270
                ....*....|....*....|....*....|....
gi 469169   287 T-----VNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15919 234 SwlvhiVSDIANMLALLNTAINFFLYCFISKRFR 267
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
52-315 4.48e-14

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 71.78  E-value: 4.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelfmLSVPFVASAAAL-----RHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15077   9 FLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVAN----LIVVCFGSTTAFysfsqMYFVLGPLACKIEGFTATLGG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSvAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHW--PHPAW- 203
Cdd:cd15077  85 MVSLWSLAVVAFERFLVICKPLGNFTFRGTH-AIIGCIATWVFGLAASLP-PLFGWSRYIPEGLQCSCGPDWytTNNKWn 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 SAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVA-LRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV- 281
Cdd:cd15077 163 NESYVMFLFCFCFGVPLSIIVFSYGRLLLTLRAVAkQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFALWVVTNr 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   282 -TSLDATVNHVSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15077 243 gEPFDLRLASIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
44-316 6.43e-14

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 71.12  E-value: 6.43e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLvglvGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVD 122
Cdd:cd15214   4 IAIIIIAILICL----GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLsVLVLPFVVTSSIRREWIFGVVWCNFSALLY 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiAVFADTRPARGGEAVACNLHW-PHP 201
Cdd:cd15214  80 LLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLP-PLFGWSSLEFDRFKWMCVAAWhKEA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTfllgFLLPVLAIGLCYLLIVGKMRAvalragwqqrrrSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15214 159 GYTAFWQVWC----ALLPFVVMLVCYGFIFRVARA------------NQCKAFITILVVLGAFVTTWGPYMVVISTEALW 222
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   282 --TSLDATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15214 223 gkNSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVRK 259
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
51-306 3.18e-13

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 69.58  E-value: 3.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFVILRYAKMKTATNIYLL--NLAVADEL--FMLSVPFVASAAALRHWPFGAVLCRA---VLSVDG 123
Cdd:cd14981   8 ALMFVFGVLGNLLALIVLARSSKSHKWSVFYRLvaGLAITDLLgiLLTSPVVLAVYASNFEWDGGQPLCDYfgfMMSFFG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LnmfTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLV-TLPIAVFadtrpargGEAVA------CNL 196
Cdd:cd14981  88 L---SSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIaSLPLLGL--------GSYVLqypgtwCFL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   197 HWPHPAWSAVFVIYTF-LLGFLLpVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITR------LVLMV--VTVFVLC 267
Cdd:cd14981 157 DFYSKNTGDAAYAYLYsILGLLI-LLVTLLCNLLVIITLLRMRRRKKRHRRSRRSARRQKrneiqmVVLLLaiTVVFSVC 235
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   268 WMPFYVVQLLNlfvTSLDATVNHVSLILSYANSCANPIL 306
Cdd:cd14981 236 WLPLMIRVLIN---ATGDSEKNGKTDLLAVRMASWNQIL 271
7tmA_GPR88-like cd15211
G protein-coupled receptor 88, member of the class A family of seven-transmembrane G ...
49-318 1.07e-12

G protein-coupled receptor 88, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR88, an orphan G protein-coupled receptor, is predominantly and almost exclusively expressed within medium spiny neurons (MSNs) of the brain's striatum in both human and rodents; thus it is also called Striatum-specific GPCR (STRG). The striatum is known to involve in motor coordination, reward-based decision making, and response learning. GPR88 is shown to co-localize with both dopamine D1 and D2 receptors and displays the highest sequence similarity to receptors for biogenic amines such as dopamine and serotonin. GPR88 knockout mice showed abnormal behaviors observed in schizophrenia, such as disrupted sensorimotor gating, increased stereotypic behavior and locomotor activity in response to treatment with dopaminergic compounds such as apomorphine and amphetamine, respectively, suggesting a role for GPR88 in dopaminergic signaling. Furthermore, the transcriptional profiling studies showed that GPR88 expression is altered in a number of psychiatric disorders such as depression, drug addiction, bipolar and schizophrenia, providing further evidence that GPR88 plays an important role in CNS signaling pathways related to psychiatric disorder. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320339 [Multi-domain]  Cd Length: 283  Bit Score: 67.95  E-value: 1.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelFMLSVPFVASAAALRHWPFGAVLCRAVL--SVDGLNM 126
Cdd:cd15211   5 VYSFLAVSGTLANVLVIYLVVSFKKLQTTSNAFIVNGCVAD--LLVCAFWMPQEAVLGSTGTLLVLGYRLFreGLLFLGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVH--PLRAATYRRPSVAKLINLGvWLASLLVTLPIAVFADTRPArggeAVACNLHWPHPAWS 204
Cdd:cd15211  83 TVSLLSHSLIALNRYVLITKlpAVYQALYQKRNTEWMIALS-WALALGLLLPWLTSFRYPTK----SCHDSADGSFAVVS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   205 AVFVIYTFLL---GFLLPVLAIGLCYLLIVGKMRAVALR----------AGWQQRRRSEKKITRLVLMVVTVFVLCWMPF 271
Cdd:cd15211 158 VLSSRYPALLlafTVLGQTALVLHCYFGIFRRVQISVKRvsvlnfqivnNLPYSRPRKDKRLGLYVLLVCCVFLLTTEPL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 469169   272 YVVQLLNLFVtSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15211 238 VWVSLAGLFV-PVPVALQTASWLLFCTLFVLNPFLYTWKNEEFRRSF 283
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
49-322 4.18e-12

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 66.08  E-value: 4.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFvILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF- 127
Cdd:cd15109   6 IFLLLCLCGLVGNGLVLW-FFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVSRILGLCTFl 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFAdTRPARGGEAVACNLhwphpawsavf 207
Cdd:cd15109  85 TGVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVTCIHNYFC-VFLGREAPGAACRH----------- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 viYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAgwqQRRRSEKKITRLVLMVVTVFVLC-------WMPFYVVQLLNLF 280
Cdd:cd15109 153 --MDIFLGILLFLLFCPLMVLPCLALILHVECRA---RRRQRSAKLNHVILAMVSVFLVSsiylgidWFLFWVFQIPAPF 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 469169   281 vtsldatVNHVSLILSYANSCANPILYgFLS---------DNFRRSFQRVL 322
Cdd:cd15109 228 -------PEYVTDLCICINSSAKPIVY-FLAgrdksqrlwEPLRVVFQRAL 270
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
49-318 6.91e-12

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 65.18  E-value: 6.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-ELFMLSVPFVASAAALRHWPFGAVLCRAVLsvdgLNMF 127
Cdd:cd15070   6 IEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADiAVGVLVIPLAIVVSLGVTIHFYSCLFMSCL----LVVF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 T--SVFCLTVLSVDRYVAVVHPLRaatYRRPSVAKLINLGV---WLASLLVTL-PIAVFADTRPARGGEAVACNLHWPHP 201
Cdd:cd15070  82 ThaSIMSLLAIAVDRYLRVKLTVR---YRIVTTQRRIWLALglcWLVSFLVGLtPMFGWNRKPSLESVNTTPLQCQFTSV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRR-----RSEKKITRLVLMVVTVFVLCWMPFYVVQL 276
Cdd:cd15070 159 MRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFREtgafyGREFKTAKSLALVLFLFAVCWLPLSIINC 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   277 LNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15070 239 VVYFNPKVPKIALYLGILLSHANSMMNPIVYACKIKKFKETY 280
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
52-322 8.44e-12

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 65.16  E-value: 8.44e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFvILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVF 131
Cdd:cd15108   9 FTCVCGMAGNGLVVW-LLSCRGRRTPFCVYVLHLAVADLLFLLCMASTLSLETSPLVITHDLAYEVVRRVKYFAYTASLS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   132 CLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFadtrparggeavaCNLHWpHPAWSAVF---- 207
Cdd:cd15108  88 LLTAISTQRCLSVLFPIWYKCHQPRHLSAVVCALLWALSLLMNVLASFF-------------CSEFW-HPDEWQCFkvdm 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCYLLivgkmraVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLnLFVTSLDAT 287
Cdd:cd15108 154 VFSFLIMGIFTPVMALSSLILF-------VRVRRSSRQWRRRPTRLYVVVLASVLVFLACALPLGIYWFL-LYWLDLPQE 225
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   288 V----NHVSLILSYANSCANPILYGFLSDNFRRSFQRVL 322
Cdd:cd15108 226 VktlfSCLSRLSSSVSSSANPVIYFLVGSRGSRRLREPL 264
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
55-318 8.45e-11

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 62.12  E-value: 8.45e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHwpFGAVLCRAVLSVDGLNMFTSVFCLT 134
Cdd:cd15103  12 IVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLN--NGYLVPRDSFEQHIDNVIDSMICSS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   135 VLS---------VDRYVAVVHPLR---AATYRRpsvAKLINLGVWLASLLVTLPIAVFADTRParggeAVACnlhwphpa 202
Cdd:cd15103  90 LLAsicsllaiaVDRYITIFYALRyhsIMTVRR---AGVIITAIWVFCTVCGILFIIYSDSVP-----VIIC-------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 wsavFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd15103 154 ----LISMFFAMLVLMASLYVHMFLLARSHVKKIAALPGQRSTRQRANMKGAVTLTILLGVFIFCWAPFFLHLTLMISCP 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   283 SLDATVNHVS-----LILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15103 230 SNPYCACYMShfnvyLILIMCNSVIDPLIYAFRSQELRKTF 270
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
49-318 1.36e-10

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 61.49  E-value: 1.36e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAAL---RHWPFGAVLCRAVLsvdglN 125
Cdd:cd15354   6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAWETITIYLlnnRHLVIEDAFVRHID-----N 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   126 MFTSVFCLTV---------LSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPArggeaVACnl 196
Cdd:cd15354  81 VFDSLICISVvasmcsllaIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCGIIFILYSESTYV-----IIC-- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   197 hwphpawsavFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL 276
Cdd:cd15354 154 ----------LITMFFAMLFLMVSLYIHMFLLARTHVKRIAALPGYNSVRQRTSMKGAVTLTILLGIFIVCWAPFFLHLI 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   277 L------NLFVTSLDATVNhVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15354 224 LmiscpqNLYCVCFMSHFN-MYLILIMCNSVIDPLIYAFRSQEMRKTF 270
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
55-309 1.72e-10

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 61.30  E-value: 1.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALViFVILRYAKMKTATNIYLLNLAVADELFMLSvPFVASAAALRHWPFGAVL-------CRAVLSVDGLNMf 127
Cdd:cd15105  12 LVGLTGNAIV-FWLLGFRLHRNAFSVYILNLALADFLFLLC-HIIDSTLLLLKVFYPNIIflpcfytIMMVLYITGLSM- 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 tsvfcLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFadtrparggeavaCNLHWPHPAWSAVF 207
Cdd:cd15105  89 -----LSAISTERCLSVLCPIWYRCRRPEHTSTVMCAVIWVLSLLICILNRYF-------------CGFLDTKYENDSVC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYTFLLGFLLPVLAIGLCyllivGKMRAVALRAGWQQRRRsekKITRL---VLMVVTVFVLCWMPF----YVVQLLNLF 280
Cdd:cd15105 151 LASNFFTAAYLMFLFVVLC-----LSSLALLARLFCGAGQM---KLTRLyvtIMLTVLVFLLCGLPFgiywFLLFWIKDD 222
                       250       260
                ....*....|....*....|....*....
gi 469169   281 VTSLDATVNHVSLILSYANSCANPILYGF 309
Cdd:cd15105 223 FHVLDYGLYLASVVLTAVNSCANPIIYFF 251
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
49-318 1.77e-10

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 61.40  E-value: 1.77e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-ELFMLSVPFVASAAALRHWPFGAvlCRAVLSVDGLNMF 127
Cdd:cd15071   6 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAIIINIGPQTEFYS--CLMVACPVLILTQ 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL-PIAVFADTRPARGGEAVACNLhwPHPAWSAV 206
Cdd:cd15071  84 SSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLtPMFGWNNLNAVERAWAANSSM--GELVIKCQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 F---------VIYTFLLGFLLPVLAIGLCYLLIVGKMRA--VALRAGWQQRRRS----EKKITRLVLMVVTVFVLCWMPF 271
Cdd:cd15071 162 FetvismeymVYFNFFVWVLPPLLLMLLIYLEVFYLIRKqlNKKVSSSSSDPQKyygkELKIAKSLALILFLFALSWLPL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   272 YVVQLLNLFVTSLDA--TVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15071 242 HILNCITLFCPSCKKpmILTYIAIFLTHGNSAMNPIVYAFRIKKFRTTF 290
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
52-320 6.16e-10

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 59.33  E-value: 6.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFvILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVF 131
Cdd:cd15107   9 IIALVGLAGNAIVLW-LLGFHMHRNAFSVYILNLAGADFLFLCTQIVFSLEIVLQFHSIDIHIPLFLLTVTMFAYLAGLS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   132 CLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPiavfadtrparggEAVACNLHWPHPAWSaVFVIYT 211
Cdd:cd15107  88 MITAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLLLSLL-------------EGKGCGFLFSTYDYY-WCWTLD 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   212 FLLGFLLPVLAIGLCyllivGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPF----YVVQLLNLFVTSLDAT 287
Cdd:cd15107 154 LITTAWLIVLFVVLS-----GSSLALLVRIFCGSHRIPVTRLYVTIALTVLVFLIFGLPFgiywFLLKWIEEFYIVPCCG 228
                       250       260       270
                ....*....|....*....|....*....|...
gi 469169   288 VNHVSLILSYANSCANPILYGFLSDNFRRSFQR 320
Cdd:cd15107 229 FYEVILFLSCVNSCANPIIYFLVGSIRHHRFQR 261
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
51-320 8.10e-10

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 59.00  E-value: 8.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    51 ALVCLVGLVGNALVIFvILRYAKMKTATNIYLLNLAVADELFmLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSV 130
Cdd:cd15106   8 CIISLVGLTGNAVVLW-LLGFRMRRNAFSVYILNLAAADFLF-LCCHIIDSLLRLINIFHIISIPKILTNVMTFPYFAGL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGgeavacNLHWphpaWSAVFVIY 210
Cdd:cd15106  86 SMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSILEWKFCGFLFSGA------DSHW----CQTFDFIT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   211 TFLLGFLLPVLAiglcyllivGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV-TSLDATVN 289
Cdd:cd15106 156 TAWLIFLFVVLC---------GSSLALLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGIQWFLLLWIhIDLEVLFC 226
                       250       260       270
                ....*....|....*....|....*....|....
gi 469169   290 H---VSLILSYANSCANPILYgFLSDNFRRSFQR 320
Cdd:cd15106 227 HvylVSVVLSCLNSSANPIIY-FFVGSFRQRQNR 259
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
44-318 1.12e-09

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 58.74  E-value: 1.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-------FMLSVPFVASAAALRHWPFGAVLCR 116
Cdd:cd15343   1 IIVLCVGTFCCLFIFVSNSLVIAAVVKNKRFHYPFYYLLANLAAADFFagiayvfLMFNTGPVSKTLTVNRWFLRQGLLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   117 AVLSVDGLNmftsvfcLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLgVWlasllvtlPIAVFADTRPARGGEAVaCNL 196
Cdd:cd15343  81 TSLSASLTN-------LLVIAVERHISIMRMKVHSNLTKRRVTLLIAL-VW--------AIAIFMGAVPTLGWNCI-CNI 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   197 HWPH---PAWSAVFVIY---TFLLGFLLPVLAIGLCYLLIVGKMRAV-ALRAGWQQRRRSEKKITRLVLMVVTVFVLCWM 269
Cdd:cd15343 144 SACSslaPIYSRSYLVFwsvSNLVVFLIMVVVYLRIYVYVQRKTNVLsPHTSGSINRRRTPIKLMKTVMTVLGAFVICWT 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   270 PFYVVQLLNlFVTSLDATVNHVS---LILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15343 224 PGLVVLLLD-GLNCTRCGVQHVKrwfLLLALLNSVMNPIIYSYKDEEMWGTM 274
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
49-317 3.79e-09

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 57.11  E-value: 3.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELfmLSVPFVASAAALRHWPFGAVLCRAVL------SVD 122
Cdd:cd15351   6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDML--VSVSNLIETLFMLLLEHGVLVCRAPMlqhmdnVID 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GL---NMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrparggeavacnlhwp 199
Cdd:cd15351  84 TMicsSVVSSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIVYYNS---------------- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 hpawSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALrAGWQQRRRSEKKITRL-----VLMVVTVFVLCWMPFYVV 274
Cdd:cd15351 148 ----NAVILCLIVFFLFMLVLMLVLYIHMFILACRHSQSI-SSQQRRQCPHQQTASLkgaitLTILLGIFFLCWGPFFLH 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 469169   275 QLL------NLFVTSLDATVNhVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15351 223 LTLivtcptHPFCLCYFKYFN-LFLILIICNSIIDPLIYAFRSQELRKT 270
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
52-318 7.29e-09

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 56.32  E-value: 7.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELfmLSVPFVASAaaLRHWPFGAVLCRAVLSVDGLNMFT--- 128
Cdd:cd15102   9 AICCFIVLENLLVLIAIWRHMKFHRPMYYFLGNLALSDLL--AGAAYLANI--LLSGARTLRLSPAQWFLREGSMFVals 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 -SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAvfadtrpargGEAVACNLhwphPAWSAVF 207
Cdd:cd15102  85 aSVFSLLAIAIERHLTMAKMKPYGASKTSRVLLLIGACWLISLLLGGLPIL----------GWNCLGAL----DACSTVL 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   208 VIYT------FLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd15102 151 PLYSkhyvlfCVTIFAGILAAIVALYARIYCLVRASGRKATRASASPRSLALLKTVLIVLLVFIACWGPLFILLLLDVAC 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   282 TSLDATV---NHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15102 231 PVKTCPIlykADWFLALAVLNSALNPIIYTLRSRELRRAV 270
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
12-325 1.09e-08

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 56.36  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     12 EDTTWTPGINASWAPDEEEDAVRSdgtgtagmvTIQCIYALVCLVGLVGNALVIFVIL---RYAKMKTATnIYLLNLAVA 88
Cdd:PHA03235  10 NDENDLLHVNDTCVPTEGLSAART---------TETFINLLIISVGGPLNLIVLVTQLlanRVHGFSTPT-LYMTNLYLA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     89 DELFMLSVPFVASAAalRHWPFGAVLCRAVLSVDGLNMFTSVFC-LTVLSVDRYvAVVHPLRAATYRRPSVAKLINLGVW 167
Cdd:PHA03235  80 NLLTVFVLPFIMLSN--QGLLSGSVAGCKFASLLYYASCTVGFAtVALIAADRY-RVIHQRTRARSSAYRSTYKILGLTW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    168 LASLLVTLPIAVFA-----DTRPARGGEAVACNLHWPHPAwsavfvIYTFLLGF---------LLPVLAIGLCYLLIVGK 233
Cdd:PHA03235 157 FASLICSGPAPVYTtvvahDDVDPEAPGYETCVIYFRADQ------VKTVLSTFkvlltlvwgIAPVVMMTWFYTFFYRT 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    234 MRAVAlragwqQRRRSEkkitrlVLMVVTVFVLCWM----PFYVVQLLNLFVT----------SLDATVNHVSLILSYAN 299
Cdd:PHA03235 231 LKRAS------YKKRSR------TLTFVCILLLSFLclqtPFVAIMIFDSYATliwpsdcehiNLRDAVSTLSRLVPNLH 298
                        330       340
                 ....*....|....*....|....*.
gi 469169    300 SCANPILYGFLSDNFRRSFQrvLCLR 325
Cdd:PHA03235 299 CLLNPILYAFLGNDFLKRFR--QCFR 322
7tmA_GPR146 cd14990
G protein-coupled receptor 146, member of the class A family of seven-transmembrane G ...
49-314 1.30e-08

G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR146 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. The endogenous ligand for GPR146 is not known. It has been suggested that GPR146 may be a part of the C-peptide signaling complex. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320121  Cd Length: 280  Bit Score: 55.56  E-value: 1.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCL-VGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWP---FGAVLCRAVLSVDGL 124
Cdd:cd14990   5 LYLIICFpVGLCYNALLVLVNLYNKASMTMPDVYFVNMAIAGLVLNAVAPVQLLGPDNTRWPlwnSNNEVYITLLILFNV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYV--AVVHPLRAATYRRPSVAKLInlgvWLASLLVTLPIAVFADTRPArGGEAVACNLHWPHPA 202
Cdd:cd14990  85 SSLVSMYSTTLLSLDYYIerALPRTYMSSVYNTKHVCGFI----WGGAVLTSFSSLLFYICSHV-STKIIECSKMQNKEA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFViytfLLGFLLPVLAIGLCYLLIVG-KMRAVALRagwQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFV 281
Cdd:cd14990 160 ADAIMV----FIGYVVPALAVLYALVLILRiRKEATPLD---QDSGRLDPSAHRLLLATVCTQFLLWTPYYMILLVHTVQ 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 469169   282 TSLDATVNH-----------VSLILSYANSCANPILYGFLSDNF 314
Cdd:cd14990 233 ASRGKKVDAgylrvfhflkgLSKLLAFSSSFVVPLLYRYMNKNF 276
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
52-315 1.43e-08

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 55.68  E-value: 1.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelfmLSVPFVASAAALRHWPFGA-VLCRAVLSVDGLNM---- 126
Cdd:cd15081  21 FVVFASVFTNGLVLVATLKFKKLRHPLNWILVNLAIAD----LGETVIASTISVVNQIFGYfILGHPMCVLEGFTVsvcg 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInLGVWLASLLVTLPiAVFADTRparggeavacnlHWPHPAWSAV 206
Cdd:cd15081  97 ITGLWSLTIISWERWVVVCKPFGNIKFDGKLAIVGI-IFSWVWSAVWCAP-PIFGWSR------------YWPHGLKTSC 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 ---------------FVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVAlragwQQRRRSE------KKITRLVLMVVTVFV 265
Cdd:cd15081 163 gpdvfsgssdpgvqsYMIVLMITCCIIPLAIIILCYLQVWLAIRAVA-----QQQKESEstqkaeKEVSRMVVVMIFAYC 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   266 LCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCA--NPILYGFLSDNFR 315
Cdd:cd15081 238 FCWGPYTFFACFAAANPGYAFHPLAAALPAYFAKSATiyNPIIYVFMNRQFR 289
7tmA_RXFP1_LGR7 cd15965
relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G ...
115-315 2.14e-08

relaxin receptor 1 (or LGR7), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. Relaxin is the endogenous ligand for RXFP1, which has a large extracellular N-terminal domain containing 10 leucine-rich repeats and a unique low-density lipoprotein type A (LDLa) module which is necessary for receptor activation. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP and nitric oxide. RXFP1 is expressed in various tissues including uterus, ovary, placenta, cerebral cortex, heart, lung and kidney, among others.


Pssm-ID: 320631 [Multi-domain]  Cd Length: 287  Bit Score: 54.88  E-value: 2.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   115 CRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATY-RRPSVAKLInlGVWLASLLVT-LPIAVFADTRPARGGEAV 192
Cdd:cd15965  80 CQLVGSLAILSTEVSVLLLTYLTLEKYICIVYPFRCLTPgKCRTITILI--LIWIIGFIIAfIPLSNKEFFRNYYGTNGV 157
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   193 ACNLHWPHPA------WSAVFVIYTFLLGFLLPVLAIGLCYLLIvgkMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVL 266
Cdd:cd15965 158 CFPLHSEQPEstgaqiYSVVIFLGLNLAAFIIIVFSYGSMFYSI---HQTAIMATEISNHIKKEMTLAKRFFFIVFTDAL 234
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 469169   267 CWMPFYVVQLLNLFVTSLDATVNH-VSLILSYANSCANPILYGFLSDNFR 315
Cdd:cd15965 235 CWIPIFILKLLSLLQVEIPGTISSwVVIFILPINSALNPILYTLTTRPFK 284
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
52-316 2.92e-08

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 54.49  E-value: 2.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVG-LVGNALVIFVILRYAKMKTATNIYLLNLAVADELFML-SVPFVASAAALRH---WPFGAVLCRAVLSVDGLNM 126
Cdd:cd15006   7 VVIFVGsLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLvCVPFDIVLSASPHccwWIYTLLFCKVIKFLHKVFC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRaatyRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAV 206
Cdd:cd15006  87 SVTVLSFAAIALDRYYSVLYPLE----RKISDAKSRDLVIYIWAHAVVASVPVFAVTNVTDIYAMSTCTESWGYSLGHLV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   207 FVIYTFLLGFLLPVLAIGLCYLLIVGKMRA--------VALRAGWQQ-----RRRSEKKITRLVLMVVTVFVLCWMPF-- 271
Cdd:cd15006 163 YVIIYNITTVILPVAVVFLFMILIRRALSAsqkkkviiAALRTPQNTisipyVSQREAELHAMLLSMVLVFILCSVPYat 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   272 YVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRR 316
Cdd:cd15006 243 LVIYRTILNISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVRK 287
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
49-318 4.01e-08

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 54.02  E-value: 4.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS------VPFVASAAAL-RHWPFGAVLCRAVLSV 121
Cdd:cd15350   6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYktleniLIILADMGYLnRRGPFETKLDDIMDSL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLR---AATYRRPSVAklinLGVwlasllvtlpIAVFAdtrparGGEAVACNLHW 198
Cdd:cd15350  86 FCLSLLGSIFSILAIAADRYITIFHALRyhnIMTMRRTLVI----LAI----------IWTFC------GGSGILMILFF 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   199 PHPAWSAVFVIYTFLLGFLLPVLAIGLcYLLIVGKMRAVALRAGWQ-QRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:cd15350 146 HFVATVICFTVLFFLMLVLILCLYVHM-FLLARSHARKIASLPNHHaQHQRSNMRGAITLTILLGVFVCCWAPFVLHLLL 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   278 NLFVTS-------LDATVNHVSLILSyaNSCANPILYGFLSDNFRRSF 318
Cdd:cd15350 225 MMFCPMnpycacyRSLFQVNGTLIMS--HAVIDPAIYAFRSPELRNTF 270
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
49-180 4.24e-08

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 54.03  E-value: 4.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKmKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd14994   7 LYSVVLIGGVIGVILMSFLLVKMNT-RSVTTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHMHL 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVF 180
Cdd:cd14994  86 TFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFVK 137
7tmA_S1PR1_Edg1 cd15346
sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial ...
49-318 1.03e-07

sphingosine-1-phosphate receptor subtype 1 (S1PR1 or S1P1), also called endothelial differentiation gene 1 (Edg1), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320468 [Multi-domain]  Cd Length: 277  Bit Score: 52.96  E-value: 1.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelfmLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFT 128
Cdd:cd15346   6 VFIIICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSD----LLAGVAYTANLLLSGATTYKLTPTQWFLREGSMFV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 ----SVFCLTVLSVDRYVAVVHpLRAATYRRPSVAKLINLGVWLASLLVT-LPIAVFADTRPARGGEAVacnLHWPHPAW 203
Cdd:cd15346  82 alsaSVFSLLAIAIERYITMLK-MKLHNGSNSFRSFLLISACWVISLILGgLPIMGWNCISALSSCSTV---LPLYHKHY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   204 sAVFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQ-RRRSEKKITRL--VLMVVTVFVLCWMPFYVVQLLNLF 280
Cdd:cd15346 158 -ILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNIRKaSRSSEKSMALLktVIIVLSVFIACWAPLFILLLLDVG 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   281 VTSLDATVNHVS---LILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15346 237 CKVKTCSILFKAeyfLVLAVLNSATNPIIYTLTNKEMRRAF 277
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
52-316 1.08e-07

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 52.60  E-value: 1.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPF--GAVLCRAVLSVDGLNMFT- 128
Cdd:cd15964   9 FVNLLAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIYLLLIASVDLHTRSEYynHAIDWQTGPGCNTAGFFTv 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 -----SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLAS-LLVTLPIavfadTRPARGGEAVACNLHWPHPA 202
Cdd:cd15964  89 faselSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCfLLALLPL-----VGVSSYAKVSICLPMDTETP 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGfLLPVLAIGLCYLLIVGKMRAVALRAGwqqrRRSEKKITRLVLMVVTVFvLCWMPFYVVQLLNLFVT 282
Cdd:cd15964 164 LAQAYIVFVLMLN-IIAFVIICACYIKIYITVRNPQYKSG----DKDTKIAKRMAVLIFTDF-ICMAPISFYALSAILNK 237
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 469169   283 SLDATVN-HVSLILSYA-NSCANPILYGFLSDNFRR 316
Cdd:cd15964 238 PLITVSNsKILLVLFYPlNSCANPFLYAIFTKAFRR 273
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
52-318 1.65e-07

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 52.17  E-value: 1.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD---ELFMLSVPFVASAAALRH------WPFGAVlCRAVLSVD 122
Cdd:cd15359   9 FINILAIAGNLIVLFVLLTSRYKLTVPRFLMCNLSFADfcmGLYLLLIASVDSQTKSQYynhaidWQTGSG-CSTAGFFT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVT-LPIAVFADTrparggeaVACNLHWPHP 201
Cdd:cd15359  88 VFASELSVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIAvLPLVGVSNY--------MKVSICLPMD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   202 AWSAVFVIYTFLLGFL--LPVLAIGLCYLLIVGKMRAVALRAgwqqRRRSEKKITRLVLMVVTVFVlCWMPFYVVQLLNL 279
Cdd:cd15359 160 IETLLSQAYILLILVLnvIAFLVICACYIKIYLAVQNPELVA----KNKDTKIAKRMAILIFTDFT-CMAPISFFAISAA 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 469169   280 FVTSLDATVN-HVSLILSYA-NSCANPILYGFLSDNFRRSF 318
Cdd:cd15359 235 FKVPLITVTNsKILLVLFYPiNSCANPFLYAIFTKAFRRDF 275
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
54-317 2.15e-07

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 51.71  E-value: 2.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    54 CLVgLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL----FMLSVpFVASAAALRHWPFGAVLCRAVLSVdglNMFTS 129
Cdd:cd15349  12 VLI-ILENLLVLLAILRRVRLRRWVYICLANIALSDLLtgtsYLVNI-CLSGERTFRLTPALWFLREGLLFT---ALAAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVW-LASLLVTLPIAvfadtrpargGEAVACNLHWPH---PAWSA 205
Cdd:cd15349  87 TFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWiLAFLIGFLPLL----------GWNCLCDFRSCSsllPLYSK 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLgFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLD 285
Cdd:cd15349 157 SYILFCLVI-FFIILLTIIGLYFAIYCLVRASGQRVISARSRRRSLRLLKTVLMILGAFMVCWGPLFILLLVDFFCSSRS 235
                       250       260       270
                ....*....|....*....|....*....|....*
gi 469169   286 ATV---NHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15349 236 CKPlfgMEWVLALAVLNSAINPLIYSFRSLEVRRA 270
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
48-172 6.54e-07

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 50.33  E-value: 6.54e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelfMLSVPFV------ASAAALRHWPFGAvlCRAVLSV 121
Cdd:cd15232   5 WLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVD---IICTSTVvpkllqNLLTERKTISFGG--CMAQLYF 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 469169   122 DGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLL 172
Cdd:cd15232  80 FTWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGML 130
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
49-318 1.38e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 49.14  E-value: 1.38e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHwpfGAVLCRAVLSVDGLNMFT 128
Cdd:cd15353   6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLN---GNDTDAQSFTVNIDNVID 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFCLTVL---------SVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTrparggeavacnlhwp 199
Cdd:cd15353  83 SVICSSLLasicsllsiAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGVLFIIYSDS---------------- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 hpawSAVFVIYTFLLGFLLPVLAIGLCYLLIVGKM---RAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQL 276
Cdd:cd15353 147 ----SVVIICLISMFFTMLALMASLYVHMFLLARLhikRIAVLPGTGPIRQGANMKGAITLTILLGVFVVCWAPFFLHLI 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 469169   277 L------NLFVTSLDATVNhVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15353 223 FyiscprNPYCVCFMSHFN-MYLILIMCNSVIDPLIYAFRSQELRKTF 269
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
45-318 1.43e-06

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 49.47  E-value: 1.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    45 TIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRH---------WPFGAVlC 115
Cdd:cd15360   2 ILRVLIWFINILAITGNIVVLAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASVDIRTKsqyynyaidWQTGAG-C 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   116 RAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLpIAVFADTRPARGGEAVACN 195
Cdd:cd15360  81 AAAGFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVAL-LPIFGISSYMKVSICLPMD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   196 LHWPHPAWSAVFVIYTFLLGFLLpvlaIGLCYLLIVGKMRAVALRAGwqqrrRSEKKITRLVLMVVTVFVLCWMP--FYV 273
Cdd:cd15360 160 IESPLSQAYIIFILVLNVLAFLI----ICACYIKIYLTVRNPNFVSS-----NSDTKIAKRMAVLIFTDFLCMAPisFFA 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   274 VQLlNLFVTSLDATVNHVSLILSYA-NSCANPILYGFLSDNFRRSF 318
Cdd:cd15360 231 ISA-SLKVPLITVSKSKILLVLFYPiNSCANPFLYAIFTKTFRRDF 275
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
48-181 3.03e-06

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 48.32  E-value: 3.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAALRHWPFGAVLCravlsvdGLNM 126
Cdd:cd15421   5 SLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTtVPKMATNFLSGRKSISFVGC-------GTQI 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 469169   127 FTSV-------FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFA 181
Cdd:cd15421  78 FFFLtlggaecLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYT 139
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
46-318 3.94e-06

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 47.93  E-value: 3.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFM-LSVPFVASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:cd15127   3 VMCLSVVIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIfFCLPLVIFHELTKKWLLGDFSCKIVPYIEVA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 NMFTSVFCLTVLSVDRYvavvhplRAATYRR----------PSVAKLINlgVWLASLLVTLPIAVF----ADTRPARGGE 190
Cdd:cd15127  83 SLGVTTFTLCALCIDRF-------RAATNVQmyyemienctSTTAKLAV--IWVGALLLALPEVVLrqlsKEDGGSGAPP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   191 AVACNLHWPHPAWSAVFVI----------YTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRS--EKKITRLVL 258
Cdd:cd15127 154 AERCVVKISTELPDTIYVLaltydgarlwWYFGCYFCLPTLFTITCSLVTARKIRRAEKACTRGNKRQIqlESQMNCTVV 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 469169   259 MVVTVFVLCWMPFYVVQLLNLFVTSLDAT-----VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15127 234 ALTILYGFCIIPENICNIVTAYMATGVSRqtmdlLHLISQFLLFFKSCVTPVLLFCLCRPFSRAF 298
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
55-180 6.48e-06

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 47.09  E-value: 6.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-------ML--------SVPFVASAA-ALRHWPFGAvlcrav 118
Cdd:cd15912  12 LLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFtsvvipkMLanllsgkkTISFAGCFAqSFFYFFLGT------ 85
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 469169   119 lsvdglnmfTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVF 180
Cdd:cd15912  86 ---------TEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTIL 138
7tmA_LPAR2_Edg4 cd15342
lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial ...
52-318 6.87e-06

lysophosphatidic acid receptor subtype 2 (LPAR2 or LPA2), also called Endothelial differentiation gene 4 (Edg4), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320464 [Multi-domain]  Cd Length: 274  Bit Score: 47.10  E-value: 6.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADeLFmlsvpfvaSAAALRHWPFGAVLCRAVLSVDG-------- 123
Cdd:cd15342   9 TVSVIVLLTNLLVIAAIFINRRFHYPIYYLLGNLAAAD-LF--------AGVAYLFLMFHTGPWTAKLSLYQwflrqgll 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 -LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInLGVWLASLLVTLpiavfadtRPARGGEAVaCNLHWPH-- 200
Cdd:cd15342  80 dTSLTASVANLLAIAVERHQTIFTMQLHSKMSNQRVVILI-FGIWMVALILGL--------IPAMGWNCL-CDLKRCStm 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 -PAWSAVFVIY---TFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQR-RRSEKKITRLVLMVVTVFVLCWMPFYVVQ 275
Cdd:cd15342 150 aPLYSRSYLVFwalSNLLTFLIMVAVYTRIFIYVRRKSQRMSEHHSSHPRyRETVLGLMKTVVIILGAFVVCWTPGQVVL 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 469169   276 LLN-LFVTSLDA-TVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15342 230 LLDgLGCESCNVlAYEKYFLLLAEINSLVNPIVYSYRDKEMRKTF 274
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
49-310 7.89e-06

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 46.93  E-value: 7.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMK-TATNIYLLNLAVADELFMLSVPFVA-SAAALRHWPFGAVLCRAVLSVDGLNM 126
Cdd:cd15169   6 LYVAAFALGFPLNVLAIRGATAHARLRlTPSLVYALNLGCSDLLLTVSLPLKAvEALASGAWPLPASLCPVFAVAHFAPL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLL-------VTLPIAVFADTRPARG------GEAVA 193
Cdd:cd15169  86 YAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLChlglvfgLEAPGGWLDHSNTSLGintpvnGSPVC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   194 CNLHWPHPAWSAVFVIYtfLLGFLLPVLAIGLCYlliVGKMRAVAlRAGWQQRRRSekKITRLVLMVVTVFVLCWMPFYV 273
Cdd:cd15169 166 LEAWDPASAGPARFSLS--LLLFFLPLAITAFCY---VGCLRALA-RSGLTHRRKL--RAAWVAGGALLTLLLCVGPYNA 237
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 469169   274 VQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFL 310
Cdd:cd15169 238 SNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYL 274
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
49-318 8.30e-06

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 46.81  E-value: 8.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFGAVLCRAVLSVDglNMFT 128
Cdd:cd15352   6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMD--NVFD 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   129 SVFC---------LTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRparggEAVACnlhwp 199
Cdd:cd15352  84 SMICislvasicnLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYSESK-----TVIVC----- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 hpawsavFVIYTFLLGFLLPVLAIGLCYL--LIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:cd15352 154 -------LITMFFAMLVLMATLYVHMFLFarLHVKRIAALPPAVDGAPQQRSCMKGAVTITILLGVFIVCWAPFFLHLIL 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 469169   278 NLFVTSLDATVNHVS-----LILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15352 227 IISCPHNPYCLCYTShfntyLVLIMCNSVIDPLIYAFRSLEMRKTF 272
PHA03234 PHA03234
DNA packaging protein UL33; Provisional
63-318 1.01e-05

DNA packaging protein UL33; Provisional


Pssm-ID: 177562 [Multi-domain]  Cd Length: 338  Bit Score: 46.85  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     63 LVIFVILRYAKM--KTATNIYLLNLAVADELFMLSVpFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDR 140
Cdd:PHA03234  52 IVICTLIIYHKVakHNATSFYLITLFASDFLHMLCV-FFLTLNREALFNFNQAFCQCVLFIYHASCSYSICMLAIIATIR 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    141 YVAVVHplRAATYRRPSVAKLiNLGV-WLASLLVTLPIAVFADTRPARGGEAvACNLHW----PHPAWSAVFVIYTFLLG 215
Cdd:PHA03234 131 YKTLHR--RKKNDKKNNHIGR-NIGIlFLASAMCAIPAALFVKTEGKKGNYG-KCNIHIsskkAYDLFIAIKIVFCFIWG 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    216 fLLPVLAIGLCYLLIVGKMRAVAlragwqqrRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDAT-------- 287
Cdd:PHA03234 207 -IFPTMIFSFFYVIFCKALHALT--------EKKHKKTLFFIRILILSFLCIQIPNIAILICEIAFLYIANNscfglaqr 277
                        250       260       270
                 ....*....|....*....|....*....|...
gi 469169    288 --VNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:PHA03234 278 eiLQIIIRLMPEIHCFSNPLVYAFTGGDFRLRF 310
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
61-318 1.10e-05

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 46.56  E-value: 1.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    61 NALVIFVILRYAKMKTATNIYLLNLAVADELfmlsvpfvASAAALRHWPFGAVLCR--AVLSVDGL---NMFTSVFCLTV 135
Cdd:cd15961  18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLL--------AGIGLILNFIFAYLLQSeaAKLVTVGLivaSFSASVCSLLA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   136 LSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASL-LVTLPIAVFADTRparggEAVACNLHWPHPAWSAVFVIYTFLL 214
Cdd:cd15961  90 ITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASIcLGLLPVMGWNCLA-----DESTCSVVRPLTKNNAAILSVSFLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   215 GF-LLPVLAIGLCYlLIVGKMRAVALRAGWQQRRR--SEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFvtSLDATVNHV 291
Cdd:cd15961 165 MFaLMLQLYIQICK-IVMRHAHQIALQHHFLATSHyvTTRKGVSTLAIILGTFAACWMPFTLYSLIADY--TYPSIYTYA 241
                       250       260
                ....*....|....*....|....*..
gi 469169   292 SLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15961 242 TLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
48-175 1.49e-05

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 46.06  E-value: 1.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFM-LSVPFVAsaaalrhwpFGAVLCRAVLSVDG--L 124
Cdd:cd15431   5 VLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTtSSVPQML---------VNCLSDRPTISYSRclA 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 469169   125 NMFTSVFC-------LTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL 175
Cdd:cd15431  76 QMYISLFLgitecllLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTV 133
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
49-146 2.12e-05

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 46.10  E-value: 2.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-FMLSVPFVAsaAALRH---WPFGAVLCRAVLSVDGL 124
Cdd:cd15217   6 LLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIrSAVCFPFVL--VSIRNgsaWTYSVLSCKIVAFMAVL 83
                        90       100
                ....*....|....*....|..
gi 469169   125 NMFTSVFCLTVLSVDRYVAVVH 146
Cdd:cd15217  84 FCFHAAFMLFCISVTRYMAIAH 105
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
55-177 3.25e-05

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 44.97  E-value: 3.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelFMLSVPFVASAAAL-----RHWPFGAVLcravlsvdglnmfTS 129
Cdd:cd15221  12 IVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTD--LLLSTTTVPKMLAIfwfgaGEISFDGCL-------------TQ 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 469169   130 VFCLTVLSV-----------DRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPI 177
Cdd:cd15221  77 MFFVHFVFVtesaillamafDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPF 135
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
50-249 3.51e-05

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 45.06  E-value: 3.51e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-ELFMLSVPFVASA--AALRHWPFGAVLCRAVLsvdgLNM 126
Cdd:cd15952   7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDlGLSTATIPKMLGIfwFNLREISFGGCLAQMFF----IHT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSV--FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVA---C-NLHWPH 200
Cdd:cd15952  83 FTGMesAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPhtyCeHMGIAK 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 469169   201 PAWSAVFVIYTFLLG----FLLPVLAIGLCYLLIvgkMRAVALRAGWQQRRRS 249
Cdd:cd15952 163 LACASIRINIIYGLFaisvLVLDVILIALSYVLI---LRAVFRLPSHDARLKA 212
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
54-322 3.79e-05

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 44.89  E-value: 3.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169      54 CLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADeLFMLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCL 133
Cdd:pfam10320   1 SVIGLFGNVLMIHLTFRKKKLRSKCSILICVQCIAH-LICLCGEIVFVVLLFTGTQLTRNECFWMISFYIFGQTAQGPLM 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     134 TVLSVDRYVAVVHPLRaatYRRPSVAKLInlgvwlaSLLVTLPIA----------VFADTRparggEAVACNLhwPHPAW 203
Cdd:pfam10320  80 LMIGIDRLIAVKFPIF---YRLLSSSKYL-------FIQLIFPVIyssfitvygfLQRDDE-----TIIVCAP--PLALP 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     204 SAVFVIYTFLLGFLlpVLAIGLCYLLIVGKMRAVAlragwQQRRRSEKKITRLVLMVVTVFVLCWMpfyVVQLLNLFVTS 283
Cdd:pfam10320 143 GTAFTIFTLSSLFI--NVIVLIVYIILIIIFKNKK-----QSQNSDSKKVFKSLQVTVVIFIFGWF---TSTIANTVFLY 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 469169     284 LDATVNHVSLILSYA------NSCANPILYGFLSDNFRRSFQRVL 322
Cdd:pfam10320 213 LTEDGEVEVIIQMYAgffvllSFSQNFFVTYWRSSEYRKAFRSLW 257
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
61-279 4.09e-05

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 44.74  E-value: 4.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    61 NALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHwpFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDR 140
Cdd:cd15905  16 NLFIILGIACNRKLHNTANYFFLSLLLADLLTGVALPFIPGMSNESR--RGYHSCLFVYVAPNFLFLSFLANLLMVHYER 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   141 YVAVVHPLRAATYRRPSVAKLINLGVWLASLLvtlpiavFAdTRPARGGEavacnlHWPHPA---WSAVFV---IYTFLL 214
Cdd:cd15905  94 YLCIVYPLQYHNFWVHRWVPLALLLTWALPLL-------FA-CLPALGWN------NWTPGSncsYKQVFPaayIYLEVY 159
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 469169   215 GFLLP-----------VLAIGLCYLLIVGKM-RAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNL 279
Cdd:cd15905 160 GLVLPsilaiafmsvrVLAVARRQLQDICKLlRAVQRDGPSELEQQLNLRYAKCIAGVSLTFLVCWVPYIAYLLMSV 236
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
49-240 5.77e-05

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 44.19  E-value: 5.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15237   6 LFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTStVPQMLVHLLSEHKTISFVGCAAQMFFFLALGV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAV---ACNLhwphPA-- 202
Cdd:cd15237  86 TECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHInhfFCEA----PAvl 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 469169   203 -------WSAVFVIYTF-LLGFLLPVLAIGLCYLLIVG---KMRAVALR 240
Cdd:cd15237 162 klacadtSLNEAVIFVTsVLVLLIPFSLILASYIRILAtilRIQSAEGR 210
7tm_classB cd13952
class B family of seven-transmembrane G protein-coupled receptors; The class B of ...
49-274 6.80e-05

class B family of seven-transmembrane G protein-coupled receptors; The class B of seven-transmembrane GPCRs is classified into three major subfamilies: subfamily B1 (secretin-like receptor family), B2 (adhesion family), and B3 (Methuselah-like family). The class B receptors have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi or prokaryotes. The B1 subfamily comprises receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the subfamily B1 receptors preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The subfamily B2 consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Furthermore, the subfamily B3 includes Methuselah (Mth) protein, which was originally identified in Drosophila as a GPCR affecting stress resistance and aging, and its closely related proteins.


Pssm-ID: 410627 [Multi-domain]  Cd Length: 260  Bit Score: 44.13  E-value: 6.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAdeLFMLSVPFVASAaaLRHWPFGAVLCRAVlsvDGLNMF- 127
Cdd:cd13952   7 ITYIGCSLSLVGLLLTIITYLLFPKLRNLRGKILINLCLS--LLLAQLLFLIGQ--LLTSSDRPVLCKAL---AILLHYf 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 --TSVFCLTVLSVDRYVAVVHPLRaatYRRPSVAKLINLGVWLASLLVTLPIAV--FADTRPARGGEAVACnlhWPHPAW 203
Cdd:cd13952  80 llASFFWMLVEAFDLYRTFVKVFG---SSERRRFLKYSLYGWGLPLLIVIITAIvdFSLYGPSPGYGGEYC---WLSNGN 153
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 469169   204 SavfviytFLLGFLLPVLAIGLC----YLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVV 274
Cdd:cd13952 154 A-------LLWAFYGPVLLILLVnlvfFILTVRILLRKLRETPKQSERKSDRKQLRAYLKLFPLMGLTWIFGILA 221
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
55-175 6.84e-05

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 44.31  E-value: 6.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VP-----FVASAAALrhwPFGavLCRAVLSVDGLNMFT 128
Cdd:cd15429  12 LLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSvVPqmlahFLAEHKTI---SFA--SCVAQLFISLALGGT 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 469169   129 SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL 175
Cdd:cd15429  87 EFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSL 133
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
49-175 1.12e-04

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 43.62  E-value: 1.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15428   6 LFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTvVPQMLVHLLSERKIISFIRCAAQLYFFLSFGI 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL 175
Cdd:cd15428  86 TECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSA 133
7tmA_S1PR5_Edg8 cd15348
sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial ...
53-317 1.13e-04

sphingosine-1-phosphate receptor subtype 5 (S1PR5 or S1P5), also called endothelial differentiation gene 8 (Edg8), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320470 [Multi-domain]  Cd Length: 277  Bit Score: 43.66  E-value: 1.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    53 VCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL--FMLSVPFVASAA-ALRHWPFGAVLCRAVLSVdglNMFTS 129
Cdd:cd15348  10 VCAFIVLENLIVLLALWRNKKFHSPMFYLLGSLTLSDLLagAAYAANILMSGAnTLKLTPALWFLREGGVFI---TLTAS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINlGVWLASLLVTLpiavfadtRPARG----GEAVACNLHWPHPAWSA 205
Cdd:cd15348  87 VFSLLAIAIERHITMVRMKPYPGDKRGRMFLLIG-AAWLVSILLGV--------LPILGwnclGNLDACSTVLPLYAKSY 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLpvlAIGLCYLLIVGKMRAVALRAGWQQRRRSEKK-------ITRLVLMVVTVFVLCWMPFYVVQLLN 278
Cdd:cd15348 158 ILFCITVFLAILA---AIVVLYARIYRIVKANSQRLGALPTRKGRARrsqkylaLLKTVTIVLGTFVACWLPLFLLLLLD 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 469169   279 LFVTSLDATVNHVS---LILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15348 235 VSCPAQACPVLLKAdyfLGLAMINSLLNPIIYTLTSRDMRRA 276
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
52-243 1.76e-04

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 42.87  E-value: 1.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAAL--RHWPFGAVLCRA----VLSVdgl 124
Cdd:cd15222   9 LLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLStLPTVLGIFWFnaREISFDACLAQMffihTFSF--- 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   125 nMFTSVfcLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEA------------- 191
Cdd:cd15222  86 -MESSV--LLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVlshsyclhqdvmk 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   192 VACNLHWPHPAWSAVFVIYTFLLGFLLpvlaIGLCYLLIVGKMRAVALRAGW 243
Cdd:cd15222 163 LACSDTRVNSIYGLFVVLSTMGLDSLL----ILLSYVLILKTVLGIASREER 210
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
44-317 2.05e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 42.52  E-value: 2.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKM-KTATNIYLLNLAVADelFMLSVPFVASAAALRhwPFGAVLCRAV--LS 120
Cdd:cd15341   1 IAIAVLCTLCGLLCILENVAVLYLILSSPKLrRKPSYLFIGSLALAD--FLASVVFACSFVDFH--VFHGVDSSAIflLK 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   121 VDGLNM-FT-SVFCLTVLSVDRYVAVVHP--LRAATYRRPSVAKLInlGVWLASLLVT-LPIAVFADTRparggEAVACN 195
Cdd:cd15341  77 LGGVTMsFTaSLGSLLLMAFDRYVCIYYPseYKALVTRKRALVALA--VMWVLTALIAyLPLMGWNCCP-----LNSPCS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   196 LHWPhpawsavFVIYTFLLGFLLPVLAIGLCYLLIVGKM-----RAVALRAGWQQRR-------RSEKKITRLVLMVVTV 263
Cdd:cd15341 150 ELFP-------LIPNDYLLSWLLLVAILLSGIIYTYGHVlwkahKHVVYMEKHQDQQgpgnarmRLDVRLAKTLGLVLAV 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   264 FVLCWMPFYVVQLLNLFVTSLDA--TVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15341 223 LLICWSPVLALMMHSLFTSLSDHikKAFAFCSTLCLVNSMVNPIIYALRSRELRSS 278
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
48-178 2.48e-04

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 42.22  E-value: 2.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYalvcLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFM-LSVP--FVASAAALRHWPFGAVLCRAVLSVDGL 124
Cdd:cd15918   9 GMY----LVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTsTTVPkmLVNIQTQSKSISYAGCLTQMYFFLLFG 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 469169   125 NMftSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVW----LASLLVTLPIA 178
Cdd:cd15918  85 DL--DNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWvitnLHSLLHTLLMA 140
7tmA_ETBR-LP2 cd15126
endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G ...
52-270 2.56e-04

endothelin B receptor-like protein 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelin B receptor-like protein 2, also called GPR37L1, is almost exclusively expressed in the nervous system. It has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37L1 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320254  Cd Length: 298  Bit Score: 42.54  E-value: 2.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFM-LSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMFTSV 130
Cdd:cd15126   9 VVFAVGIVGNLSVMCIVWHSYYLKSAWNSILASLALWDFLVLfFCLPVVVFNEITKKRLLGDVSCRVVPYMEVTSLGVTT 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   131 FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGV-WLASLLVTLPIAVF----ADTRPARGGEAVACNLhwpHPAWSA 205
Cdd:cd15126  89 FSLCALGIDRFHAATSPQPKARPVERCQSILAKLAViWVGSMTLAVPELLLwqlaQETSPGSGMVIDTCIM---KPSPNL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLG-------------FLLPVLAIGLCYLL---IVGKMRAVALRAGwQQRRRSEKKITRLVLMVVTVFVLCWM 269
Cdd:cd15126 166 PESLYSLVLTyqnarmwwyfgcyFCLPILFTVTCQLVtlrVSGTSGSSKECKD-IKHGQCERQLNCTVAGLAVVYGVCTL 244

                .
gi 469169   270 P 270
Cdd:cd15126 245 P 245
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
55-175 3.17e-04

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 42.21  E-value: 3.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    55 LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-------MLSVPFVASAAAlrhwPFGAVLCR-----AVLSVD 122
Cdd:cd15235  13 LLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFtsttvpkMLANLLSGSKTI----SYAGCLAQmyffiAFGNTD 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 469169   123 GlnmftsvFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL 175
Cdd:cd15235  89 S-------FLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSL 134
7tmA_S1PR3_Edg3 cd15345
sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial ...
206-318 3.50e-04

sphingosine-1-phosphate receptor subtype 3 (S1PR3 or S1P3), also called endothelial differentiation gene 3 (Edg3), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320467 [Multi-domain]  Cd Length: 270  Bit Score: 42.11  E-value: 3.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   206 VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVAlragwqQRRRSEKKIT--RLVLMVVTVFVLCWMPFYVVQLLNLFVTS 283
Cdd:cd15345 159 AFCISIFIAILVAIVILYARIYILVKSSSRRVT------NHRNSERSMAllRTVVIVVGVFIACWSPLFILLLIDVACEV 232
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 469169   284 LDATVNHVS---LILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15345 233 KQCPILYKAdwfIALAVLNSAMNPIIYTLASKEMRRAF 270
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
58-170 3.74e-04

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 42.03  E-value: 3.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    58 LVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVP-FVASAAALRHwpfgavlcraVLSVDGL--NMF------ 127
Cdd:cd15228  15 LLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFsSVSTPkMLAYLWGQSR----------VISLGGCmsQVFfyhflg 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 469169   128 -TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLAS 170
Cdd:cd15228  85 sTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITS 128
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
44-176 4.04e-04

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 41.56  E-value: 4.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-------MLSVPFVASaaalRHWPFGAVLCR 116
Cdd:cd15951   1 VWISIPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLststlpkMLSIFWFNS----REIDFSACLTQ 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   117 AVLsVDGLNMFTSVFCLTvLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP 176
Cdd:cd15951  77 MFF-IHSFSTMESGIFVA-MALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSP 134
7tmA_LPAR cd15101
lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane ...
44-318 5.62e-04

lysophosphatidic acid receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 341325 [Multi-domain]  Cd Length: 274  Bit Score: 41.34  E-value: 5.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-------FMLSVPFVASAAALRHWPFGAVLCR 116
Cdd:cd15101   1 VLVMGLGITVCIFIMLANLLVIAAIYKNRRFHFPIYYLLANLAAADFFaglayffLMFNTGPNTRRLTVSTWFLRQGLLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   117 AVLSvdglnmfTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLInLGVWLasllvtlpIAVFADTRPARGGEAV---- 192
Cdd:cd15101  81 TSLT-------ASVANLLAIAVERHISVMRMQLHSRLSNRRVVVLI-VLVWT--------MAIVMGAIPSVGWNCLcaid 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   193 ACNLHWPHPAWS-AVFVIYTFLLGFLLPVLAIGLCYLLIVGK-MRAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMP 270
Cdd:cd15101 145 ACSNMAPLYSRSyLVFWAISNLVTFLVMVVVYARIFVYVRRRtNRMSPHTSGSIRNRDTMMSLLKTVVIVLGAFVVCWTP 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 469169   271 FYVVQLLNLfVTSLDATVNHVS---LILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15101 225 GLVVLLLDG-LCCRQCNVLAVEkffLLLAEFNSAVNPIIYSYRDKEMSGTF 274
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
56-146 1.15e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 40.40  E-value: 1.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    56 VGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-FMLSVPFV-ASAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCL 133
Cdd:cd15218  13 VSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILrSAICFPFVfTSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFML 92
                        90
                ....*....|...
gi 469169   134 TVLSVDRYVAVVH 146
Cdd:cd15218  93 FCISVTRYLAIAH 105
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
50-308 1.19e-03

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 40.35  E-value: 1.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelfmLSVPFVASAAALRHWPFGA---VLCRAVLSVDGLNM 126
Cdd:cd15223   7 FLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVD----IVLATTILPKMLAIFWFDAntiSLPGCFAQMFFIHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   127 FTSVFC--LTVLSVDRYVAVVHPLRAATYRRPS-VAKLINLGVwLASLLVTLPIAVFADTRPARGG---EAVACNlhwpH 200
Cdd:cd15223  83 FTAMESsiLLVMALDRYVAICKPLRYPSIITKSfILKLVLFAL-IRSGLLVLPIVVLASQLSYCSSnviEHCYCD----H 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   201 PAWS-------AVFVIYTFLLGFLLPV---LAIGLCYLLIvgkMRAVaLRAGWQQRRRSEKKITRLVLMVVTVFVLCWMP 270
Cdd:cd15223 158 MALVslacgdtTINSIYGLAVAWLIVGsdiILIFFSYALI---LRAV-LRLASGEARSKALNTCGSHLIVILFFYTAVLV 233
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 469169   271 FYVVQLLNLFVTSLDATVNHVSLILsyANSCANPILYG 308
Cdd:cd15223 234 SSLTYRFGKTIPPDVHVLLSVLYIL--IPPALNPIIYG 269
7TM_GPCR_Srx pfam10328
Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis ...
52-258 1.33e-03

Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 431215  Cd Length: 262  Bit Score: 39.89  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169      52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPFG-AVLCRAVLSVDGLN-MFTS 129
Cdd:pfam10328   2 LISLIGLVANLLVFIAFLKLPSLKNSFGILCLSQAIGNAIICLIFLFYVVPMTLFQNSFLpEWLNSHIIGLIAMGlYEIS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     130 VFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIavfadtrpargGEAVACNLHWPHPAWSAVFV- 208
Cdd:pfam10328  82 PLSHLLIALNRFCAVFFPLKYEKIFSIKNTKIIIIFIWIVSIIFCTVF-----------YEPEGCHFYYNPETLTWSFEd 150
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     209 --------IYTFLLGFLLPVLAIGLCYLLIVGK--MRAVALRAGWQQRRRSEKKITRLVL 258
Cdd:pfam10328 151 tpccdfitWYLDFYKNLSLVIITLFLNLLTAIKlrVSKKKSNTSSSESKRRRKREINFFK 210
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
48-180 1.73e-03

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 39.77  E-value: 1.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    48 CIYalvcLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-------MLSVpFVASaaalrhwpfgavlcRAVLS 120
Cdd:cd13954   9 LIY----LLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYtsvtvpkMLAN-LLSG--------------DKTIS 69
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 469169   121 VDG--LNMF-------TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVF 180
Cdd:cd13954  70 FSGclTQLYfffslggTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVL 138
7tmA_RXFP2_LGR8 cd15966
relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G ...
112-315 1.75e-03

relaxin receptor 2 (or LGR8), member of the class A family of seven-transmembrane G protein-coupled receptors; Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural similarity, but low sequence similarity, and exert their physiological functions by activating a group of four G protein-coupled receptors, RXFP1-4. INSL3 is the endogenous ligand for RXFP2, which couples to the G(s) protein to increase intracellular cAMP levels, but also to the GoB protein to decrease cAMP formation. RXFP2 (or LGR8) is expressed in various tissues including the brain, kidney, muscle, testis, thyroid, uterus, and peripheral blood cells, among others.


Pssm-ID: 320632  Cd Length: 287  Bit Score: 39.77  E-value: 1.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   112 AVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLraaTYRRPSVAK--LINLGVWLASLLVTLPIAVFADTRPARGG 189
Cdd:cd15966  77 SLQCRIIGFLAMLSTEVSVLLLTYLTLEKYLVIVFPF---SNIRPGKCQtlIILISIWLVGFIIAVIPFWNEDFFGNYYG 153
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   190 EAVACNLHWPHPAWSAVFVIYTF--LLGF-LLPVLAIGLCYLLIVGKMRAVALRAGWQQRR-RSEKKITRLVLMVVTVFV 265
Cdd:cd15966 154 KNGVCFPLHSDQTEKIGAKGYSTgiFLGLnLLAFIIIVFSYSSMFCSIQKTGLQTTEVRSHiHRDVAVANRFFFIVFSDA 233
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 469169   266 LCWMPFYVVQLLNLFVTSLDATVNH--VSLILSyANSCANPILYGFLSDNFR 315
Cdd:cd15966 234 ICWIPIFLLKILSLFQVEIPGTITSwiVIFILP-INSALNPILYTLTTSFFK 284
7tmA_CB1 cd15340
cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...
245-318 1.97e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320462 [Multi-domain]  Cd Length: 292  Bit Score: 39.89  E-value: 1.97e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 469169   245 QRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLF--VTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15340 217 DQTRMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFgkMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAF 292
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
46-318 2.18e-03

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 39.44  E-value: 2.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMK-TATNIYLLNLAVADelFMLSVPFVASAAALRhwPFGAVLCRAV--LSVD 122
Cdd:cd15099   3 IAVLCFLAGPVTFLENILVLLTILSSTALRrRPSYLFIGSLALAD--MLASVIFTISFLDFH--VFHQRDSRNLflFKLG 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNM-FT-SVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVW-LASLLVTLPIAVFADTRPARggeavACNLHWP 199
Cdd:cd15099  79 GVTMaFTaSVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWcVTIIISFLPLMGWRCKTWDS-----PCSRLFP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   200 HpawsavfVIYTFLLGFLLPVLA----IGLCYLLIVGKM-RAVALRAGWQQRRRSEKKITRLVL---------MVVTVFV 265
Cdd:cd15099 154 Y-------IDRHYLASWTGLQLVllflIIYAYPYILWKAhRHEANMGGPKLGRQQVKGQARMRMdirlaktlsLILLVLA 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 469169   266 LCWMPFYVVQLLNLFVT--SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15099 227 ICWLPVLAFMLVDVRVTltNKQKRMFAFCSMLCLVNSCVNPIIYALRSRELRGAM 281
7tmA_GPR185-like cd15960
G protein-coupled receptor 185 and similar proteins, member of the class A family of ...
61-318 2.25e-03

G protein-coupled receptor 185 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR185, also called GPRx, is a member of the constitutively active GPR3/6/12 subfamily of G protein-coupled receptors. It plays a role in the maintenance of meiotic arrest in Xenopus laevis oocytes through G(s) protein, which leads to increased cAMP levels. In Xenopus laevis, GPR185 is primarily expressed in brain, ovary, and testis; however, its ortholog has not been identified in other vertebrate genomes. GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest.


Pssm-ID: 320626 [Multi-domain]  Cd Length: 268  Bit Score: 39.50  E-value: 2.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    61 NALVIFVILRYAKMKTATNIYLLNLAVADEL--FMLSVPFVASAAALRHWpfgAVLCRAVLSVDGLNmfTSVFCLTVLSV 138
Cdd:cd15960  18 NAIVIAILFYTPSLRAPMFILIGSLALADLLagLGLIANFVAIYVMNSEA---VTLCSAGLLLAAFS--ASVCSLLAITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   139 DRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLV-TLPIAVFADTRparggEAVACNLHWPHPAWSAVFVIYTFLLGF- 216
Cdd:cd15960  93 DRYLSLYNALTYHTERTLTFTYGLLALLWLTCIGIgLLPAMGWNCLR-----APASCSVLRPVTKNNAAVLAVSFLLLFa 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   217 LLPVLAIGLCYLLIVGKMRAVALR--AGWQQRRRSEKKITRLVLMVVTvFVLCWMPFYVVQLLNlfVTSLDATVNHVSLI 294
Cdd:cd15960 168 LMMQLYLQICRIAFRHAQQIAVQHqfVNFCLASSTRKGVSTLSLILAT-FAFCWVPFAVYSMVA--DSSYPMIYTYYLVL 244
                       250       260
                ....*....|....*....|....
gi 469169   295 LSYANSCANPILYGFLSDNFRRSF 318
Cdd:cd15960 245 PAACNSVINPIIYAFRNPDIQKSL 268
7tmA_MrgprE cd15112
mas-related G protein-coupled receptor subtype E, member of the class A family of ...
44-322 2.93e-03

mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320240  Cd Length: 272  Bit Score: 39.05  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    44 VTIQCIYALVCLVGLVGNALVIFvILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALR-HWPFGAVLCRAVLSVD 122
Cdd:cd15112   1 LFILSLTELLGLGGLLGNGLVLW-LLSSNVYRNPFSIYLLDVACADLIFLCCHMVAIIPELLQnHLSFPHFVYDSLLALR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   123 GLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVfadtrparggeavACNLHWPHPA 202
Cdd:cd15112  80 FFCYIVGLSLLAAISAEQCLATLFPAWYQCRRPRHLTTCVCALLWALCLLLHLLLSG-------------ACTQFFGGPS 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSavfviYTFLLGFLLPVLAIGLCYLLIVGKMrAVALRAGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd15112 147 GH-----LCGRLWLVRAVLLALLCCTMCVSSL-VLLLRVERGPPRQRPRGFPALVLLTVLLFLFCGLPFGIYWLSLNLLW 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 469169   283 SLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVL 322
Cdd:cd15112 221 RIPHYFYHFSFLMAAVHSAAKPPIYFCLGSLRGGRFREPL 260
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
52-172 3.14e-03

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 38.97  E-value: 3.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADeLFMLSVP----FVASAAALRHWPFGAvlCRA-VLSVDGLnM 126
Cdd:cd15227   9 LIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLD-LCYISVTvpksIANSLTNTRSISFLG--CVAqVFLFIFF-A 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 469169   127 FTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLL 172
Cdd:cd15227  85 ASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLL 130
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
53-323 3.31e-03

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 39.11  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169      53 VCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASAAALRHWPF---------GAVLCRAVLSV-- 121
Cdd:pfam10324   6 LSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIISYENsecippdsyLKVLLDWILESlq 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     122 DGLNMFTSVFCLTVLSVdRYVAVVHPLRAATYR--RPSVAKLINLGVWLASLLVTlpIAVFADTRPARGGE----AVACN 195
Cdd:pfam10324  86 DYSRRCSTWLGVFMALI-RTLVVKNPMSNKIQKlsKPKFGLIIIIIVFILSLPIS--IFYYFRYEIVEVGGiwkpPPNCA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     196 LHWPHP---------------AWSAVFVIYTFLLG--------FLLPVLAIglcyLLIVG--KMRAVALRAGWQQRRRSE 250
Cdd:pfam10324 163 GFPPNYtetryvlvvselftaNDGLLLKIFLLIDGifskiipcILLPILTI----LLIIElrKAKKSRKNLSSSSKNKSD 238
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 469169     251 KKiTRLVLMVVTVFVLCWMP---FYVVQLL---NLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLC 323
Cdd:pfam10324 239 RT-TKLVIFMTISFFIAEFPlgiSYIIQFFftdNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFG 316
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
49-175 3.31e-03

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 38.83  E-value: 3.31e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELF-MLSVPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15915   6 LFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYsSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGS 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTL 175
Cdd:cd15915  86 SEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHAL 133
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
49-168 3.44e-03

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 38.85  E-value: 3.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelfmLSVPFVASAAALRHWpfgaVLCRAVLSVDG--LNM 126
Cdd:cd15936   6 VFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLD----ISFSSVTAPKMLSDL----LSQTKTISFNGcmAQM 77
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 469169   127 F-------TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWL 168
Cdd:cd15936  78 FffhftggAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWL 126
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
131-176 3.79e-03

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 38.71  E-value: 3.79e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 469169   131 FCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP 176
Cdd:cd15234  89 FLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLL 134
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
49-185 4.15e-03

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 38.61  E-value: 4.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLS-VPFVASAAALRHWPFGAVLCRAVLSVDGLNMF 127
Cdd:cd15946   6 VFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTtVPQMLVHLLSHKKTISFTGCVAQMYIFLALGI 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 469169   128 TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRP 185
Cdd:cd15946  86 TECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLP 143
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
46-318 4.27e-03

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 38.64  E-value: 4.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    46 IQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADelFMLSVPFVASA--AALRHWPFGAVLCRAVLSVDG 123
Cdd:cd15347   3 ASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSD--LLAGVAFIANIllSGSVTFRLTPVQWFIREGTAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   124 LNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINlGVWLASLLV-TLPIAVFADTrpargGEAVACNLHWPHPA 202
Cdd:cd15347  81 ITLSASVFSLLAIAIERHVAITKVKLYGSDKNCRMVLLIG-ACWVISIVLgGLPILGWNCI-----GNLEDCSTVLPLYS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFllgFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITrlvlMVVTVFVLCWMPFYVVQLLNLFVT 282
Cdd:cd15347 155 KHYILFVVTI---FSIILLSIVILYVRIYCIVRSSHAEMAAPQTLALLKTVT----IVLGVFIVCWLPAFIILLLDTSCK 227
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   283 SLDATV-NHVSLILSYA--NSCANPILYGFLSDNFRRSF 318
Cdd:cd15347 228 VKSCPIlYKADYFFSVAtlNSALNPVIYTLRSKDMRKEF 266
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
50-323 7.10e-03

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 37.87  E-value: 7.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169      50 YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVAD-ELFMLSVPFVASA--AALRHWPFGAVLCRAVLsVDGLNM 126
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDlGLSASTLPTVLGIfwFGLREISFEACLTQMFF-IHKFSI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     127 FTSVFCLTvLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACN--LHWPHPAWS 204
Cdd:pfam13853  80 MESAVLLA-MAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSycLHMGLARLS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169     205 A-------VFVIYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGwqqrrrsekkitRLVLMVVTVFVLCWMPFYVVQLL 277
Cdd:pfam13853 159 CadikvnnIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREG------------RLKALNTCGSHVCAVLAFYTPMI 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 469169     278 NLFVTSLDAtvNHVSLILSYANSCA--------NPILYGFLSDNFRRSFQRVLC 323
Cdd:pfam13853 227 GLSMVHRFG--HNVPPLLQIMMANAylffppvlNPIVYSVKTKQIRDCVKRMLL 278
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
52-317 7.13e-03

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 37.84  E-value: 7.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    52 LVCLVGLV---GNALVIFVILRYAKMKTATNIYLLNLAVADelfmlsvpFVASAAALRHWPFGAVLCRAVLSVDGLNMF- 127
Cdd:cd15100   6 VLCVSGTLiacENAIVVAIIFSTPSLRAPMFLLIGSLALAD--------LLAGLGLILHFVFRYCVYSEALSLVSVGLLv 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   128 ----TSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVW-LASLLVTLPIAVFADTRparggEAVACNLHWPHPA 202
Cdd:cd15100  78 aafsASVCSLLAITVDRYLSLYNALTYYSERTLTFTYVMLALLWtLALGLGLLPVLGWNCLR-----EGSSCSVVRPLTK 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169   203 WSAVFVIYTFLLGF-LLPVLAIGLCYLlIVGKMRAVALRAGW---QQRRRSEKKITRLVLMVVTvFVLCWMPFYVVQLLN 278
Cdd:cd15100 153 NHLAVLAVAFLLVFaLMLQLYAQICRI-VLRHAHQIALQRHFlapSHYVATRKGVSTLALILGT-FAACWIPFAVYCLLG 230
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 469169   279 lfVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRS 317
Cdd:cd15100 231 --DGSSPALYTYATLLPATYNSMINPIIYAFRNQDIQKV 267
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
49-200 8.65e-03

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 37.46  E-value: 8.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 469169    49 IYALVC-LVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSV--PFVASAAALRHWpFGAVLCRAVLSVDGLN 125
Cdd:cd15433   5 VVVLIFyLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTvpQLLANLRGPALT-ITRGGCVAQLFISLAL 83
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 469169   126 MFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRParggeavACNLHWPH 200
Cdd:cd15433  84 GSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERP-------LCGHRLLD 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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