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Conserved domains on  [gi|207108|gb|AAA42190|]
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synaptic vesicle amine transporter [Rattus norvegicus]

Protein Classification

amine MFS transporter( domain architecture ID 13024382)

amine major facilitator superfamily (MFS) transporter belonging to the solute carrier family 18 facilitates the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 124-472 0e+00

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 633.46  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   124 DLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVA 203
Cdd:cd17384  25 DYLNENVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   204 GMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKG 283
Cdd:cd17384 105 GMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEG 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   284 TPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCAL 363
Cdd:cd17384 185 TPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSL 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   364 LGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGA 443
Cdd:cd17384 265 LGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGA 344

                       330       340
                ....*....|....*....|....*....
gi 207108   444 IAKAIGFPWLMTIIGIIDIAFAPLCFFLR 472
Cdd:cd17384 345 IVKSIGFPWLMRIIGIINILYAPLLFFLR 373
 
Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 124-472 0e+00

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 633.46  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   124 DLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVA 203
Cdd:cd17384  25 DYLNENVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   204 GMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKG 283
Cdd:cd17384 105 GMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEG 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   284 TPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCAL 363
Cdd:cd17384 185 TPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSL 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   364 LGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGA 443
Cdd:cd17384 265 LGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGA 344

                       330       340
                ....*....|....*....|....*....
gi 207108   444 IAKAIGFPWLMTIIGIIDIAFAPLCFFLR 472
Cdd:cd17384 345 IVKSIGFPWLMRIIGIINILYAPLLFFLR 373
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
131-433 1.03e-33

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 130.48  E-value: 1.03e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLAS 210
Cdd:COG2814  46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIAD 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 VYTdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLL 290
Cdd:COG2814 126 LVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   291 KDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVG 370
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 207108   371 ISILCIPFAKNIYGLIAPNFGVGFAIFMVdssMMPIMGYLVDLRHVSVYGSVYAIADVAFCMG 433
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLL---FPLLQALVAELAPPEARGRASGLYNSAFFLG 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
133-274 4.99e-33

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 122.37  E-value: 4.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     133 GLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVY 212
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 207108     213 TdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPS 274
Cdd:TIGR00880  81 P-PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
131-438 7.72e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 110.97  E-value: 7.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLAS 210
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     211 VYTdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVL-------QPSRVQPESQKG 283
Cdd:pfam07690 113 WFP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRpppeskrPKPAEEARLSLI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     284 TPLTTLLKDPYILIAAGSICFAnMGIAMLEPALPIWmMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR---WL 360
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFG-FAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRrrrLL 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 207108     361 CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVsvyGSVYAIADVAFCMGYAIGP 438
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER---GTASGLYNTAGSLGGALGP 344
emrD PRK11652
multidrug transporter EmrD;
149-248 6.66e-05

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 45.28  E-value: 6.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108    149 FIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSsvagmGMLASVYTDDEERGKPMGIALGG 228
Cdd:PRK11652  62 FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVG-----GVMARTLPRDLYEGTQLRHANSL 136

                         90       100
                 ....*....|....*....|....
gi 207108    229 LAMGVLVGP---PF-GSVLYEFVG 248
Cdd:PRK11652 137 LNMGILVSPllaPLiGGLLTTLFG 160
 
Name Accession Description Interval E-value
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 124-472 0e+00

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 633.46  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   124 DLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVA 203
Cdd:cd17384  25 DYLNENVRVGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVA 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   204 GMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKG 283
Cdd:cd17384 105 GMGMLASLYPDDKERGKAMGIALGGLALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVKSEESEEG 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   284 TPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCAL 363
Cdd:cd17384 185 TPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKIGRWLCSL 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   364 LGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGA 443
Cdd:cd17384 265 LGMLLVGISLILIPLAKNIYGLIIPHFGLGLGIGMVDSSMMPLLAYLVDLRHSSVYGSVYAIADVAFCLAFALGPSLGGA 344

                       330       340
                ....*....|....*....|....*....
gi 207108   444 IAKAIGFPWLMTIIGIIDIAFAPLCFFLR 472
Cdd:cd17384 345 IVKSIGFPWLMRIIGIINILYAPLLFFLR 373
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 124-472 4.97e-126

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 372.80  E-value: 4.97e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   124 DLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVA 203
Cdd:cd17383  24 DYLNEDIAIGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTA 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   204 GMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQP----SRVQPE 279
Cdd:cd17383 104 GLAMIADRFTEEAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPvrreTRANMP 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   280 SQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR- 358
Cdd:cd17383 184 EPVGTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPHVLGVYLTVKLAAKYPHy 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   359 -WLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIG 437
Cdd:cd17383 264 qWLMAAVGLAIEGASCFIVPFCTNFGVLIIPLCGICFGIALVDTALLPTLGFLVDVRHVSVYGSVYAIADISYSLAYALG 343

                       330       340       350
                ....*....|....*....|....*....|....*
gi 207108   438 PSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLR 472
Cdd:cd17383 344 PIVAGQIVHSIGFTQLNIGIGLANLLYAPVLLLLR 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 123-472 1.69e-77

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 247.87  E-value: 1.69e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   123 RDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSV 202
Cdd:cd17325  24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   203 AGMGMLASVYTDdEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQ- 281
Cdd:cd17325 104 AAMALIADIAPP-EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRa 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   282 -----KGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKM 356
Cdd:cd17325 183 vsaarLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   357 GRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHvsvYGSVYAIADVAFCMGYAI 436
Cdd:cd17325 263 GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG---RGTAMGLFNTAFSLGMVL 339

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 207108   437 GPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLR 472
Cdd:cd17325 340 GPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
131-433 1.03e-33

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 130.48  E-value: 1.03e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLAS 210
Cdd:COG2814  46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIAD 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 VYTdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLL 290
Cdd:COG2814 126 LVP-PERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELL 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   291 KDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVG 370
Cdd:COG2814 205 RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 207108   371 ISILCIPFAKNIYGLIAPNFGVGFAIFMVdssMMPIMGYLVDLRHVSVYGSVYAIADVAFCMG 433
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLL---FPLLQALVAELAPPEARGRASGLYNSAFFLG 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
133-274 4.99e-33

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 122.37  E-value: 4.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     133 GLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVY 212
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 207108     213 TdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPS 274
Cdd:TIGR00880  81 P-PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
131-438 7.72e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 110.97  E-value: 7.72e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLAS 210
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIAD 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     211 VYTdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVL-------QPSRVQPESQKG 283
Cdd:pfam07690 113 WFP-PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRpppeskrPKPAEEARLSLI 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     284 TPLTTLLKDPYILIAAGSICFAnMGIAMLEPALPIWmMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR---WL 360
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFG-FAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRrrrLL 269

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 207108     361 CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVsvyGSVYAIADVAFCMGYAIGP 438
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER---GTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
129-477 6.01e-25

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 106.11  E-value: 6.01e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   129 NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGML 208
Cdd:COG2271  44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   209 ASvYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLaalvlldGAIQLFVLqpsrvqpesqkgtPLTT 288
Cdd:COG2271 124 AE-WFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLIL-------GLPGLLLA-------------LLRF 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   289 LLkdpyILIAAGSICFANMGIAMLepaLPIWMMETmcsRKWQLGVAFLPASISYL---IGTNIFGILAHKMGR--WLCAL 363
Cdd:COG2271 183 WL----LALAYFLVYFALYGFLTW---LPTYLVEV---RGLSLAQAGLLLSLPFLagiVGSLLGGWLSDRLGRrrKLVLA 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   364 LGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVsvyGSVYAIADVAFCMGYAIGPSAGGA 443
Cdd:COG2271 253 IGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKAR---GTASGLVNTFGFLGGALGPLLVGY 329

                       330       340       350
                ....*....|....*....|....*....|....
gi 207108   444 IAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAK 477
Cdd:COG2271 330 LLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 131-460 7.80e-25

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 106.15  E-value: 7.80e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAF----SSSYAFL---LIARSLQGIGSSCSSVA 203
Cdd:cd17385  35 IIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFldrvPDGTVFIalcFLVRIVEAVGFAAFITA 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   204 GMGMLASVYTDDeergkpMGIALGGL----AMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLqPSRVQPE 279
Cdd:cd17385 115 SFAIIAKEFPNN------IATVLGTLetfsGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFIL-PRYDDDP 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   280 SQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSrKWQLGVAFLPASISYLIGTNIFGILAHKMG-R 358
Cdd:cd17385 188 SPKSGSMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHLRQFKLS-PGQVGLMFLILAGSYAISAPLWGWLSDKKKiP 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   359 WLCALLGMVIVGISILCI------PFAKNIY----GLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIADV 428
Cdd:cd17385 267 KWLMVIGSIITGVGFLLLgpapllPIKSELWmviiGLVLLGLSLGAALVPTFPELLNCAREYGFPDNLSTYGLVSGLFNA 346

                       330       340       350
                ....*....|....*....|....*....|..
gi 207108   429 AFCMGYAIGPSAGGAIAKAIGFPWLMTIIGII 460
Cdd:cd17385 347 AFSLGAFIGPTLGGFLLERLGFEWAATIQAGL 378
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 129-469 8.85e-23

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 99.81  E-value: 8.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   129 NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGML 208
Cdd:cd06174  30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALI 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   209 ASVyTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKT--APFLVLAALVLLDGAIQLFVLQPSR--------VQP 278
Cdd:cd06174 110 ADL-FPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFLIAAALALLAAILLLLVVPDPPesarakneEAS 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   279 ESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHK-MG 357
Cdd:cd06174 189 SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIG 268

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   358 RWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVdssMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIG 437
Cdd:cd06174 269 RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGL---LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIG 345

                       330       340       350
                ....*....|....*....|....*....|...
gi 207108   438 PSAGGAI-AKAIGFPWLMTIIGIIDIAFAPLCF 469
Cdd:cd06174 346 PLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 129-472 7.89e-22

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 96.89  E-value: 7.89e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   129 NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGML 208
Cdd:cd17489  30 EAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLV 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   209 ASvYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLT- 287
Cdd:cd17489 110 AD-IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAf 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   288 TLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSrkwQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMV 367
Cdd:cd17489 189 RRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS---NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLL 265

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   368 IVGISILCIPFAKNIYGLI--APNFGVGFaifmvdSSMMPIMGYL-VDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAI 444
Cdd:cd17489 266 LLALGLLLLSFAGSPWMLLlaAVLYGLGF------GLLFPALQALaVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339

                       330       340
                ....*....|....*....|....*...
gi 207108   445 AKAIGFPWLMTIIGIIDIAFAPLCFFLR 472
Cdd:cd17489 340 AELFGYRAMFLLAAVVVLLALVLYIFLL 367
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
131-479 4.65e-20

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 92.25  E-value: 4.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGmLAS 210
Cdd:COG2223  41 QLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIA-LVS 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 VYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTL- 289
Cdd:COG2223 120 KWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQl 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   290 --LKDPYILIAAGSICFANMGIAMLEPALPIWMMETMcsrKWQLGVAFLPASISYL---IGTNIFGILAHKMGRWLCALL 364
Cdd:COG2223 200 eaLRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF---GLSAATAGLLAALFALlgaLGRPLGGWLSDRIGGRRVLLI 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   365 GMVIVGISILCIPFA-KNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVsvyGSVYAIADVAFCMGYAIGPSAGGA 443
Cdd:COG2223 277 VFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNA---GAVYGLVGAAGGLGGFLGPLLFGA 353

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 207108   444 IAKAIG-FPWLMTIIGIIDIAFAPLCFFLRSPPAKEE 479
Cdd:COG2223 354 LLDATGsYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 131-471 1.21e-19

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 90.69  E-value: 1.21e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIgsSCSSVAGMGM-LA 209
Cdd:cd17324  35 QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGL--AHGGFWAIAAaYA 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   210 SVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVL--QPSRVQPESQKGTPLT 287
Cdd:cd17324 113 ADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLpsLPPKKPGSLGLLSSLL 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   288 TLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMV 367
Cdd:cd17324 193 LLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLL 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   368 IVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMmpiMGYLVDL--RHVSVYGSVYAiadVAFCMGYAIGPSAGGAIA 445
Cdd:cd17324 273 LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSAL---QTRVLRLapEARGLASSLYL---AAYNLGGALGAALGGLVL 346

                       330       340
                ....*....|....*....|....*.
gi 207108   446 KAIGfpWLMTIIGIIDIAFAPLCFFL 471
Cdd:cd17324 347 DHGG--WAGVGWVGAALLLLALLLAL 370
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 131-469 6.30e-19

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 88.02  E-value: 6.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAgmGMLAS 210
Cdd:cd17330  35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVA--QAYIA 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 VYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRvqpesqkgtplttll 290
Cdd:cd17330 113 DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLR--------------- 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   291 kdpYILIAAgsiCFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLI-GTNIFGILAHKMGRWLCALLGMVIV 369
Cdd:cd17330 178 ---RLLLVY---FLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILaQLLLIPRLAKRLGERKLLRLGLLLA 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   370 GISILCIPFAKNIYGLIAPNFGVGFAifmvDSSMMPIMGYLVDlRHVSVY--GSVYAIADVAFCMGYAIGPSAGGAIAKA 447
Cdd:cd17330 252 IIGLLLLPFASSVPLLVLAAAILAFG----TGIVFPALSALLS-KSVPSKeqGKAQGIIQSLQSLARIIGPLLAGPLYSF 326

                       330       340
                ....*....|....*....|....
gi 207108   448 IG--FPWLMTiIGIIDIAFAPLCF 469
Cdd:cd17330 327 LGpgVPFLLA-AGLLLIALFLLSL 349
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 131-471 5.16e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 85.70  E-value: 5.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLAS 210
Cdd:cd17474  35 QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGD 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 VYTDDeERGKPMGIALGGLAMGVLVGPPFGSVLYEFvGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTL- 289
Cdd:cd17474 115 LFEGG-ERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLk 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   290 --LKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFG-ILAHKMGRWLCALLGM 366
Cdd:cd17474 193 kaLRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGL 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   367 VIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYaiaDVAFCMGYAIGPSAGGAIAK 446
Cdd:cd17474 273 LLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLY---NFVRFLGQAVGPLLFGLLLE 349

                       330       340
                ....*....|....*....|....*
gi 207108   447 AIGFPWLMTIIGIIDIAFAPLCFFL 471
Cdd:cd17474 350 IFGLSAPFLVGAAIALAAAVLLALL 374
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 130-467 6.60e-18

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 85.36  E-value: 6.60e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   130 VQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLA 209
Cdd:cd17329  35 SIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIA 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   210 SVyTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFvGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTP---- 285
Cdd:cd17329 115 DV-TTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEilrg 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   286 LTTLLKD-PYILIAAGSICFAnMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALL 364
Cdd:cd17329 193 YKIVLRDrAFLLFLLASFLIS-LIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMI 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   365 GMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIadvAFCMGYAIGPSAGGAI 444
Cdd:cd17329 272 GILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYAL---AWGLGRAIGPLVGGLL 348

                       330       340
                ....*....|....*....|...
gi 207108   445 AKAIGFPWLMTIIGIIDIAFAPL 467
Cdd:cd17329 349 LDLLGPGLPWLILAALGLIAAAL 371
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
130-450 1.51e-17

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 84.95  E-value: 1.51e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   130 VQVGLLFASKATVQLLTNPFIGLLTNR-----------IGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSS 198
Cdd:COG2211  46 ALVGLILLVARLWDAITDPLIGALSDRtrtrwgrrrpwILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYT 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   199 CSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLdGAIQL------FVLQ 272
Cdd:COG2211 126 LVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIF-AVLGLlaflltFFGT 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   273 PSRVQPESQKGTP---LTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIF 349
Cdd:COG2211 205 KERPVPEEEKVSLkesLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   350 GILAHKMGRWLCALLGMVIVGISILCIPFAK--NIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRH----VSVYGSVY 423
Cdd:COG2211 285 PRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgRRREGLYF 364

                       330       340
                ....*....|....*....|....*..
gi 207108   424 AIADVAFCMGYAIGPSAGGAIAKAIGF 450
Cdd:COG2211 365 GIFTFAIKLGQALAGALAGLLLALFGY 391
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 132-465 1.38e-14

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 75.30  E-value: 1.38e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   132 VGLLFASKATVQLltnpFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASV 211
Cdd:cd17320  40 LSAYLLGFALGQL----LYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   212 YtDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLT---- 287
Cdd:cd17320 116 Y-SGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLlray 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   288 -TLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGM 366
Cdd:cd17320 195 kRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGL 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   367 VIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSM-MPIMGYLVDLRHVSVYGSVYAiadVAFCMGYAIGPSAGGAIA 445
Cdd:cd17320 275 LLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLiFPNATSLALEPFPHVAGTASA---LLGFLQFLIGALAGALVG 351

                       330       340
                ....*....|....*....|....*
gi 207108   446 KAIG-----FPWLMTIIGIIDIAFA 465
Cdd:cd17320 352 LLPNgtalpMGLLILVLGLLALLLL 376
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 148-444 1.88e-14

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 74.90  E-value: 1.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   148 PFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYtDDEERGKPMGIALG 227
Cdd:cd17321  49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGA 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   228 GLAMGVLVGPPFGSVLYEFVGKTAPFlvlaalvlldgAIQLFVLqpsrvqpesqkgtpLTTLLKDPYILIAAGSICFANM 307
Cdd:cd17321 128 VVGIGAALGPLLGGLLLELFGWRWIF-----------LINVPIG--------------LVALLLARTFSGAVLAAFLLGA 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   308 GIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAK--NIYGL 385
Cdd:cd17321 183 ALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGadSSVWL 262

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 207108   386 IAPN---FGVGFAIFMVdssmmPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAI 444
Cdd:cd17321 263 LLPGlvlLGLGLGLFAT-----PLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
129-478 2.45e-14

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 74.51  E-value: 2.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   129 NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGML 208
Cdd:COG0738  42 DAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   209 ASVYtdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEF---VGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQ---K 282
Cdd:COG0738 122 AALG--PETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEaagS 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   283 GTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCA 362
Cdd:COG0738 200 AASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLL 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   363 LLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFcmgyAIGPSAGG 442
Cdd:COG0738 280 RLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGG----AIGPPLIG 355

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 207108   443 AIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKE 478
Cdd:COG0738 356 FLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
MFS_1 pfam07690
Major Facilitator Superfamily;
301-480 5.38e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 73.22  E-value: 5.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     301 SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAK 380
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     381 NIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVsvyGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGII 460
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER---GRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180
                  ....*....|....*....|
gi 207108     461 DIAFAPLCFFLRSPPAKEEK 480
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRP 180
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 130-471 5.80e-14

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 73.42  E-value: 5.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   130 VQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAF-----SSSYAFLLIARSLQGIGSSCSSVAG 204
Cdd:cd06173  34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASAFFGPAR 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   205 MGMLASVyTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGT 284
Cdd:cd06173 114 QALLPEL-VPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSL 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   285 P-------LTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMG 357
Cdd:cd06173 193 LlrdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   358 RWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDlrhVSVYGSVYAIADVAFCMGYAIG 437
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP---DELRGRVFSVYNALNSGAMPLG 349

                       330       340       350
                ....*....|....*....|....*....|....
gi 207108   438 PSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFL 471
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 142-444 7.85e-14

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 72.97  E-value: 7.85e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   142 VQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARS-LQGIGSSCSSVAGMGMLASVYtdDEERGK 220
Cdd:cd17352  50 VSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGvLGGLGLGLIYSPAIVIVGQYF--EKKRGL 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   221 PMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLaalvlldGAIQLFVLQpsrvqpesqkGTPLTTLLKDPYILIAAG 300
Cdd:cd17352 128 ATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLIL-------GGLCLNLCV----------CGLLLRLLKDPTFVLLAL 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   301 SICFANMGIamlePALPIWMMETMCSRKWQLGVAFLPASI---SYLIGTNIFGILAHK--MGRWLCALLGMVIVGISILC 375
Cdd:cd17352 191 GVSFAMLGF----FVPFVYLPSYAKSLGIDESDAAFLLSIigiSDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLA 266

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   376 IPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSV-YGSVYAIAdvafCMGYAIGPSAGGAI 444
Cdd:cd17352 267 FPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNaYGLVLLFQ----GLAALVGPPIAGLL 332
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 131-469 9.83e-14

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 72.59  E-value: 9.83e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLAS 210
Cdd:cd17478  32 QAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQ 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 VYTDDeeRGKPMGI-ALGGlAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLdGAIQLFVLQP--SRVQPESQKGTPLT 287
Cdd:cd17478 112 AAGGR--RGLAMSIfSVGG-NLGFALGPLIAAALVALFGGLGLLILLIIPGLA-VALLLLRLRPlkKPEAKKAAAKSSAR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   288 TLLKDPY-----ILIAAGSICFANMGIAMLepaLPIWMMETMCSrKWQLGVA---FLPASIsylIGTNIFGILAHKMGRW 359
Cdd:cd17478 188 STLKGVWralllLLIIVFLRSWVLSSLTTF---LPFYLVQRGYS-LVFAGLLlslFLFAGA---IGTLIGGPLSDRFGRR 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   360 LCALLGMVIVGISILCIPFAKNIygLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVyaIADVAFCMGyAIGPS 439
Cdd:cd17478 261 RVIIASLLLAAPFLLLFLLTPGI--WSYILLVLAGFLLFASFPVTVVLAQELLPGNVGLASGL--MMGLSFGLG-GIGAP 335

                       330       340       350
                ....*....|....*....|....*....|
gi 207108   440 AGGAIAKAIGFPWLMTIIGIIDIAFAPLCF 469
Cdd:cd17478 336 VLGALADAFGLESVLLILALLPLLGALLAF 365
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 131-467 1.03e-13

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 72.59  E-value: 1.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLAS 210
Cdd:cd17477  32 LIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNA 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 VyTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGktAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLL 290
Cdd:cd17477 112 L-ATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA--LPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLR 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   291 KDPYILIAAGSICFANMGIAMLepaLPIWMMETMCSrkwQLGVAFLPASIsyLIGTNIF----GILAHKMGRWLCALLGM 366
Cdd:cd17477 189 IAPLALLGAFVAGFLEGAFYSL---LPLYGLRLGLS---VAQAALLLAAF--VLGGLLLqwplGWLADRFDRRRVLLGCA 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   367 VIVGISILCIPFAKNIYGLIAPNFGV-GFAIFmvdsSMMPI-MGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAI 444
Cdd:cd17477 261 LLGALAALLLPLVPGLPLALLVLLFLwGGAAG----PLYTLaLALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336

                       330       340
                ....*....|....*....|...
gi 207108   445 AKAIGFPWLMTIIGIIDIAFAPL 467
Cdd:cd17477 337 MDAFGPHGLFLFLAAVALLFLLF 359
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 301-495 8.47e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 66.83  E-value: 8.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   301 SICFANMGIAMLEPALPIwMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAK 380
Cdd:cd17325   4 ALFLDMLGYGIIIPILPL-YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   381 NIYGLIAPNF--GVGFAIFMVdssmmPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPW---LMT 455
Cdd:cd17325  83 SYWQLLLARFlqGLASAAVWP-----AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRApflVCA 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 207108   456 IIGIIDIAFAplCFFLRSPPAKEEKMAILMDHNCPIKRKM 495
Cdd:cd17325 158 ALALLALVLA--LLLLPEPRPPPNKRAVSAARLRSGLRLL 195
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 161-471 1.82e-11

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 65.67  E-value: 1.82e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   161 IPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTdDEERGKPMGIALGGLAMGVLVGPPFG 240
Cdd:cd17323  65 PVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFT-PEERGKAMGVYSLGPLLGPALGPIIG 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   241 SVLYEFVGKTAPFLVLAALvlldGAIQLFVLqpsrvqpesqkgtplttLLKDPYILIAAGSICFANMGIAMLEPALPIWM 320
Cdd:cd17323 144 GFITQSLGWRWIFWFLAII----SGFCLILI-----------------FLFLPIVLLLGLYVGLVYAILYLFLTAFPYVF 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   321 METMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCA-----------LLGMVIVGIsilCIPFAKNIYG----- 384
Cdd:cd17323 203 GEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRLKKknggkpepearLPPAFIGAF---LFPIGLFIFGwtiyp 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   385 ---LIAPNFGVGFAIFMVDSSMMPIMGYLVDLrHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIID 461
Cdd:cd17323 280 hihWIVPIIGSAFFGFGLMLIFQSSLTYLVDS-YPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAFTLLAFIS 358

                       330
                ....*....|
gi 207108   462 IAFAPLCFFL 471
Cdd:cd17323 359 LAMIPIPFIF 368
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 132-463 1.97e-11

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 65.71  E-value: 1.97e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   132 VGLLFASKATVQLLTNPFIGLLTNRIG-YPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSScSSVAGMGMLAS 210
Cdd:cd17490  33 IGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAA-TWVSFTVLYAS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 vYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLdGAIQLFVLQPSRVQPESQKGTP--LTT 288
Cdd:cd17490 112 -YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVL-GFILSLFIKEERREKKPVLTELkeLLS 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   289 LLKDPYILIA---AGSICFANMGIAMlePALPIWMMETMCSRkWQLGVAFLPASISYLIGTNIFGILAH-KMGRWLCALL 364
Cdd:cd17490 190 VLKDKKLLFFsllAILQQMITFSTTF--GFTPLIAKQLGASS-FQLGLLSIIYLLPNALASLLSGTLFYkKLGERNTIII 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   365 GMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMM--PIMGYLVDLRH--VSVYGSVYAIadvafcmGYAIGPSA 440
Cdd:cd17490 267 GFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMslSIEGVPAEQRStaMGFFQAIYAL-------GMFLGPVL 339

                       330       340
                ....*....|....*....|...
gi 207108   441 GGAIAKAIGFPWLMTIIGIIDIA 463
Cdd:cd17490 340 VGIISEAFGLQTGFFVIGVIALL 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
295-480 3.94e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.61  E-value: 3.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   295 ILIAAGSICFANMGIAMLEPALPiWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISIL 374
Cdd:COG2814  12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   375 CIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVsvyGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLM 454
Cdd:COG2814  91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERR---GRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                       170       180
                ....*....|....*....|....*.
gi 207108   455 TIIGIIDIAFAPLCFFLRSPPAKEEK 480
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAAR 193
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 148-464 1.12e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 63.39  E-value: 1.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   148 PFiGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGsSCSSVAgMGMLASvYTDDEERGKPMGIALG 227
Cdd:cd17472  51 PF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG-AISSVV-MALLAD-LTREENRTKAMALIGA 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   228 GLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTP--LTTLLKDPYILIAAGSICFA 305
Cdd:cd17472 127 SIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKkkLKKLLKNKRLLRLDFSIFIL 206

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   306 NMGIAMLEPALPIWMMETMCSRKwQLGVAFLPASISYLIGTNIFGILAHKMGR-WLCALLGMVIVGISILC-IPFAKNIY 383
Cdd:cd17472 207 HFVLMAFFYILPLLLTQLGGGKG-QLWKVYLPAILIGFILMVPFVIYAEKKGKmKQVFVSSILLIAVGFLLlLFAATSLW 285

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   384 GLIApnfgvGFAIFMVDSSMM-PIMGYLV-DLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIID 461
Cdd:cd17472 286 LLII-----GLIIFFIGFNLLeALLPSLVsKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILA 360


                ...
gi 207108   462 IAF 464
Cdd:cd17472 361 LLW 363
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 145-456 1.51e-10

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 63.06  E-value: 1.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   145 LTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGI 224
Cdd:cd17355  53 LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGI 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   225 ALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVlldGAIQLFVLQPSRVQPESQKGTP------------LTTLLKD 292
Cdd:cd17355 133 LTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLA---LLVLVPVLLLLRRRPADLALRAyddaspaspgstLKEALRS 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   293 PYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKwQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGIS 372
Cdd:cd17355 210 ASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPA-AAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALG 288

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   373 ILCIPFAKN-IYGLIApnFGVGFAIFMVdsSMMPIMGYLV----DLRHvsvYGSVYAIADVAFCMGYAIGPSAGGAIAKA 447
Cdd:cd17355 289 LALLLLLPFpPLALLL--FAALFGLGWG--ATVPLTAALAaryfGARS---YGTLFGLVFAPHQLGSALGPWLGGLLYDR 361

                       330
                ....*....|..
gi 207108   448 IG---FPWLMTI 456
Cdd:cd17355 362 TGsytAAWALAV 373
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 133-452 1.90e-10

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 62.67  E-value: 1.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   133 GLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSvAGMGMLASVy 212
Cdd:cd17391  39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVP-NATALIASQ- 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   213 TDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTL--- 289
Cdd:cd17391 117 TPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKMVSTKEVwns 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   290 LKDPYILIAAGSICFAN-MGIAMLEPALPIWMMETMCSrkwQLGVAFLP------ASISYLIGTNIFGILAHKMGRWLCA 362
Cdd:cd17391 197 VPNPSLLISLFVTTFIIqLANQSIEPILTLYIRQLMGD---ASNLAFISglvfsaTGVSSLLSAPRLGKLGDRIGHHRIL 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   363 LLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAifmvDSSMMP-IMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAG 441
Cdd:cd17391 274 LGALLASALLYIPQAFVQTPWQLGILRFLLGLA----TGGLLPaINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLG 349

                       330
                ....*....|.
gi 207108   442 GAIAKAIGFPW 452
Cdd:cd17391 350 SAIAAHFGYRA 360
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 131-374 3.95e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 60.98  E-value: 3.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLAS 210
Cdd:COG0477  50 QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAE 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 VYTdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLdGAIQLFVLQPSRVQPESQKGTPLTTLL 290
Cdd:COG0477 130 LFP-ARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALL 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   291 KDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVG 370
Cdd:COG0477 208 LAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLL 287


                ....
gi 207108   371 ISIL 374
Cdd:COG0477 288 LLLL 291
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 169-444 3.64e-09

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 58.36  E-value: 3.64e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   169 IMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAgMGMLaSVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVG 248
Cdd:cd17504  70 IYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLA-FALV-REEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   249 KTAPFLVLAALvlldgAIQLFVLqpsrvqpesqkgTPL--TTLLKDPYILIAAGSICFANMGIAMLEPALPIWMME---- 322
Cdd:cd17504 148 WRWIFWTAAPV-----AVLLAAL------------VPLidLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptpt 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   323 TMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPF-AKNIYGLIAPNFGVGFAIFMVDS 401
Cdd:cd17504 211 GFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFA 290

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 207108   402 SMMPIMGYLVDLRHVSVYGSVYAiadVAFCMGYAIGPSAGGAI 444
Cdd:cd17504 291 SLPNIVVESVPPDRTGIATGMNT---VLRTIGSAIGPAIAGAI 330
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
295-482 3.95e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.35  E-value: 3.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   295 ILIAAGSICFANMGIAMLEPALPIWMMETMcsrKWQLGVAFLPASISYLIGTN---IFGILAHKMGRWLCALLGMVIVGI 371
Cdd:COG2223   6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEF---GLSAAQLGLLFAIPVLVGALlriPLGFLVDRFGPRRVLLIGLLLLGI 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   372 SILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVsvyGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFP 451
Cdd:COG2223  83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRR---GLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                       170       180       190
                ....*....|....*....|....*....|..
gi 207108   452 WLMTIIGIIDIAFAPLC-FFLRSPPAKEEKMA 482
Cdd:COG2223 160 NAFLILGILLLVVAVLAwLFLRDPPAGAAAAA 191
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 131-472 4.32e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 55.27  E-value: 4.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLAS 210
Cdd:cd17473  36 LVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGD 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   211 VYtDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFvGKTAPFLVLAALVLLDGAIQLFVLQPSRV-QPESQKGTPLTTL 289
Cdd:cd17473 116 YF-EGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPARKsKSAASPGAATAAA 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   290 LKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIV 369
Cdd:cd17473 194 LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALM 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   370 GISILCIPFAKNIYGLIAPN--FGVGFAIfmvdssMMP-IMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAK 446
Cdd:cd17473 274 ALGFLLLALASGLWVVLLGAilAGLGFGL------LLPtLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVN 347

                       330       340
                ....*....|....*....|....*..
gi 207108   447 AIGFPWLM-TIIGIIDIAFAPLCFFLR 472
Cdd:cd17473 348 LTGGLSGAfLILGVLALVLAIVLLLLR 374
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 131-460 3.49e-07

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 52.16  E-value: 3.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMF-ISTVMFAFSSSYAFLLIARS-LQGIGSSCSSVAgMGML 208
Cdd:cd17471  33 QIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGaLGYLLFAFLRNYWVLLLVGVvLLSLGAAAFPQL-FALA 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   209 ASVYTDDEERGKPMGIAL--GGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVL-QPSRVQPESQKGTP 285
Cdd:cd17471 112 REYADRSSGRDATLFNSVlrAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLpSVKPPAQKATPASS 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   286 LTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAF-------LPASIsyligtnIFGILAHKMGR 358
Cdd:cd17471 192 LVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFglaaaleIPIML-------LAGLLAKRFGK 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   359 WLCALLGMVIVGISILCIPFAKNIYGLIAPNF--GVGFAIFMVDSsmmpiMGYLVDLRHVSVyGSVYAIADVAFCMGYAI 436
Cdd:cd17471 265 RRLLLAGFLAGVLFYLGLALATSLWQLIALQLlnAIFIGITAGLG-----ISYFQDLMPGQP-GLATTLYSNASRIGSLL 338

                       330       340
                ....*....|....*....|....*..
gi 207108   437 GPSAGGAIAKAIGFP---WLMTIIGII 460
Cdd:cd17471 339 GGLLAGVIAQYFGYRavfLVCAVLALL 365
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 113-449 3.90e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 52.24  E-value: 3.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   113 TVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMfaGFCIMFISTVMFA--FSSSYAFLLIAR 190
Cdd:cd17328  17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWIL--AVGILIWSAATLLssFAPNFWQLLLFR 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   191 SLQGIG-SSCSSVAgmGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVG--KTApFLVLAALVLLDGAIQ 267
Cdd:cd17328  95 ALVGIGeASYSPIA--PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGgwRWA-FRVTGVLGVLLAILL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   268 LFVLQPSRVQPESQKGTPLTT----------LLKDP-YILIAAGSIC--FANMGIAMLEPALpiwMMETMCSRKWQ---L 331
Cdd:cd17328 172 LLFVREPPRGAAEGGVMAKSTatsfladlkaLAKNPsFILSTLGFTAvsFVTGALAFWAPTF---FLRAFGVGDLSsadV 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   332 GVAFLPAS-ISYLIGTNIFGILAHKMGR-------WLCALLGMVIVGISILCIPFA-KNIYGLIAPNFGVGFAIFMVDSS 402
Cdd:cd17328 249 GLIFGAITcIAGVLGVLLGGILADRLRRktpradpLVCAVGLLAAAPFLFLALVLAlSNLLLAWVLLFLGEFLLSLNWAP 328

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 207108   403 MMPIMGYLVDLRHVSvygSVYAIaDVAFCM--GYAIGPSAGGAIAKAIG 449
Cdd:cd17328 329 VFAILLYVVIPTRRS---TASAI-QILLSHllGDAGSPYLIGLISDLLR 373
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 140-396 1.39e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 50.25  E-value: 1.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   140 ATVQLLTN----PFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSscssvAGMGMLASVYTDD 215
Cdd:cd17502  36 GTAYLLTStafqPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGG-----GGLMSLAFIIIAD 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   216 ----EERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLvlaalvlldgaIQLFVlqpsrvqpesqkGTPLTTLLK 291
Cdd:cd17502 111 lvppRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY-----------INLPI------------GGLALALLR 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   292 DPYILIAAGSICFANMGIAMLEpaLPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGR--------WLCAL 363
Cdd:cd17502 168 TILLSSIFGFLFGGALFGLIYY--LPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRykplivigTILMS 245

                       250       260       270
                ....*....|....*....|....*....|...
gi 207108   364 LGMVIVGISILCIPFAKNIYGLIAPNFGVGFAI 396
Cdd:cd17502 246 VGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGF 278
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 307-480 1.56e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.50  E-value: 1.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   307 MGIAMLEPALPIWMMETMCSrKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLI 386
Cdd:cd06174  10 LARGLISPLLPALLQSFGLS-ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   387 APNFGVGFAIFMVDSSMMPIMGYLVDLRHVsvyGSVYAIADVAFCMGYAIGPSAGGAIAKAI--GFPWLMTIIGIIDIAF 464
Cdd:cd06174  89 LGRFLLGLGSGLIDPAVLALIADLFPERER---GRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLA 165

                       170
                ....*....|....*.
gi 207108   465 APLCFFLRSPPAKEEK 480
Cdd:cd06174 166 AILLLLVVPDPPESAR 181
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 129-471 5.78e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 48.34  E-value: 5.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   129 NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGML 208
Cdd:cd17319  37 PTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKAL 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   209 ASVYTDdEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQpsRVqpesqkgtpltt 288
Cdd:cd17319 117 AEWFPA-RERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR--QV------------ 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   289 llkdpyILIAAGSICFaNMGIAMLEPALPIWMMETMCSRKWQLGvafLPASISYL---IGTNIFGILAHKMGRW---LCA 362
Cdd:cd17319 182 ------WGLALGYFGI-NYALYGLLTWLPTYLKQARGFSLKQVG---LLAAIPFLagaIGMILGGRLSDRLLRGarrLVI 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   363 LLGMVIVGISILCIPFAKNIYGLIApnfGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGG 442
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTTSPVVAVI---LLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIG 328

                       330       340       350
                ....*....|....*....|....*....|
gi 207108   443 AIAKAIG-FPWLMTIIGIIDIAFAPLCFFL 471
Cdd:cd17319 329 YLVDATGsYTAAFLFLAAVALLAALLVLLL 358
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
129-460 9.42e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.95  E-value: 9.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   129 NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGML 208
Cdd:COG2807  52 ATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLI 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   209 ASVYtdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAI-QLFVLQPSRVQPESQKGTPLT 287
Cdd:COG2807 132 KRWF--PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLwLPLLRRRPAAAAAAPAAASLR 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   288 TLLKDPYILIAAGSICFANMGIAMLEPALPIWMMEtmcsRKW---QLGVAFLPASISYLIGTNIFGILAHKMGR---WLC 361
Cdd:COG2807 210 SLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD----AGLsaaTAGLLLSLFQLAGIPGSLLVPLLADRLGDrrpLLL 285

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   362 ALLGMVIVGISILCIPFAKNIYGLIAPnFGVGFAIFMVDSSMMPIMgylvDLRHVSVYGSVYAiadVAFCMGY---AIGP 438
Cdd:COG2807 286 LLGLLGLAGLLGLLLAPGSLPWLWAVL-LGLGQGGLFPLALTLIGL----RARTPAEAAALSG---MAQSVGYllaALGP 357

                       330       340
                ....*....|....*....|....*
gi 207108   439 SAGGAIAKAIG---FPWLMTIIGII 460
Cdd:COG2807 358 LLVGALHDATGswtAALLLLAALAV 382
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 129-465 9.46e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 47.60  E-value: 9.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   129 NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGsscssVAGMGML 208
Cdd:cd17316  35 LLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIG-----IGGEYPG 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   209 ASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRvqpesqkgtpltt 288
Cdd:cd17316 110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLR------------- 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   289 llkdPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVI 368
Cdd:cd17316 177 ----RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   369 vgISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMG-YLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKA 447
Cdd:cd17316 253 --SGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYaYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330

                       330
                ....*....|....*...
gi 207108   448 IGFPWLMTIIGIIDIAFA 465
Cdd:cd17316 331 TGGTGVPALILALLAIVA 348
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 149-467 1.02e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 47.92  E-value: 1.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   149 FIGLLTNRIG-YPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVyTDDEERGKPMGI--A 225
Cdd:cd17370  53 FSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADA-TPPSGRGKAFGLhrA 131

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   226 LGGLamGVLVGPPFGSVLYEFVGKtaPFLVLAALVLLDGAIQLFVL-------QPSRVQPESQKGTPLTTLLKDPYILIA 298
Cdd:cd17370 132 LDTL--GAVLGPLLAALLLYLLGG--NYRTIFLLAAIPALLALLILlfvvkeyPRPPKLRKKSKKTSLKKLPKAFWLYLL 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   299 AGSIcfanMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPF 378
Cdd:cd17370 208 AVAL----FALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFAL 283

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   379 AKNIYGLIapnfgVGFAIFMVDSSMMPIMG--YLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTI 456
Cdd:cd17370 284 GSSLWLLL-----LGFILWGLYMGAQESIEraAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358

                       330
                ....*....|.
gi 207108   457 IGIIDIAFAPL 467
Cdd:cd17370 359 SAVLALIALLL 369
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 137-407 1.69e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.19  E-value: 1.69e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   137 ASKATVQLLTN----------PFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMG 206
Cdd:cd17503  28 ASLDTVQWVITsyllalaimiPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQT 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   207 MLASVYtDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALvlldgAIQLFVLqpsrvqpesqkgTPL 286
Cdd:cd17503 108 ILLRIY-PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI-----GILALLL------------APL 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   287 --TTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALL 364
Cdd:cd17503 170 ldLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 207108   365 GMVIVGISILCIPFA---KNIYGLIAPNFGVGFAIFMVdssMMPIM 407
Cdd:cd17503 250 GLLLLALGTLLLAFLtpdTSLWLIILPLFIRGLGMGLV---FMPLN 292
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 295-471 1.91e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 46.73  E-value: 1.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   295 ILIAAGSICFANMGIAMLEPALPIwMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISIL 374
Cdd:COG0477  16 LLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   375 CIPFAKNIYGLIAPNFGVGFAIfmvdSSMMPI-MGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWL 453
Cdd:COG0477  95 LCGLAPSPELLIAARALQGIGA----GGLMPGaLALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWI 170

                       170
                ....*....|....*...
gi 207108   454 MTIIGIIDIAFAPLCFFL 471
Cdd:COG0477 171 FLINAPLGLLALVLRLRL 188
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 131-207 3.35e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 46.03  E-value: 3.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAF---SSSYAFLLIARSLQGIGSSCSSVAGMGM 207
Cdd:cd17503 215 ESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTL 294
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 131-462 3.39e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 46.06  E-value: 3.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARS-LQGIGSSCSSVAGMGMLA 209
Cdd:cd17353  39 SVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGvLGGIGAGIGYITPVSTAV 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   210 SVYTDdeERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLaalvlldGAIQLFVL--------------QPSR 275
Cdd:cd17353 119 KWFPD--KRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLIL-------GIIFLIIIvigaflirdppkgwVPPG 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   276 VQPESQKGTPLTT------LLKDPYILIAAGSICFANMGIAMLepalpIWMMETMCSRKWQLGVAFLPASISYL-----I 344
Cdd:cd17353 190 VDPLANNAENSPRdytpreMLRTPTFWLLWLMFFLNATAGLML-----IGQAKPIGQEFAGLDAGIAALAVSILsifngG 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   345 GTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIApnFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYA 424
Cdd:cd17353 265 GRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFV--LGVALIGFCYGGGFALFPALTADFFGTKNAGTNYG 342

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 207108   425 IADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDI 462
Cdd:cd17353 343 LLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSL 380
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 131-289 3.84e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 46.09  E-value: 3.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIG-YPIPMF--AGFCIMFIstvMFAFSSSYAFLLIARSLQGIGSSCSSVAgMGM 207
Cdd:cd17388  39 HYGVLLALYALMQFIFAPILGALSDRFGrRPVLLLslAGAALDYL---LMAFAPTLWWLYLGRIIAGITGATGAVA-AAY 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   208 LASVyTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFvGKTAPFLVLAALVLLDGAIQLFVLQPSRvQPESQKGTPLT 287
Cdd:cd17388 115 IADV-TPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEI-SPRAPFLVAAGLNGLNFLLGLFVLPESL-PPERRRAFRWR 191


                ..
gi 207108   288 TL 289
Cdd:cd17388 192 RA 193
emrD PRK11652
multidrug transporter EmrD;
149-248 6.66e-05

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 45.28  E-value: 6.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108    149 FIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSsvagmGMLASVYTDDEERGKPMGIALGG 228
Cdd:PRK11652  62 FYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVG-----GVMARTLPRDLYEGTQLRHANSL 136

                         90       100
                 ....*....|....*....|....
gi 207108    229 LAMGVLVGP---PF-GSVLYEFVG 248
Cdd:PRK11652 137 LNMGILVSPllaPLiGGLLTTLFG 160
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 133-243 8.58e-05

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 44.89  E-value: 8.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   133 GLLFASKATVQLLTNPFIGLLTNRIG-YPIPMFAGFCIMFISTVMFAFSSSYA-----FLLIARSLQGIGssCSSVAGMG 206
Cdd:cd17326  39 GWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFPsnrkyVMLVARFLIGVG--AGNVAVLR 116

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 207108   207 MLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVL 243
Cdd:cd17326 117 AYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAF 153
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 296-480 9.03e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.87  E-value: 9.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   296 LIAAGSICF-ANMGIAMLEPALPIwMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISIL 374
Cdd:cd17474   1 LYAVFFATLlAVLGVSIVDPILPA-IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   375 CIPFAKNIYGLIAPNF--GVGFAIFMVDSSMMpimgyLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAkAIG--F 450
Cdd:cd17474  80 LCGLSDSFALLLAGRAlqGIGAAGLGPLALTL-----IGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISwrY 153

                       170       180       190
                ....*....|....*....|....*....|
gi 207108   451 PWLMTIIGIIdIAFAPLCFFLRSPPAKEEK 480
Cdd:cd17474 154 PFFLLAALIP-VAFLAILFLLPEPKEKAKS 182
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 302-477 1.31e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 44.12  E-value: 1.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   302 ICFAN----MGIAMLEPALPIWMMETMCSrkwqLGVAFLPASIsYLIGTNIF----GILAHKMGRWLCALLGMVIVGISI 373
Cdd:cd17489   1 ILLANffffLSFYLLLPVLPLYAHDLGGS----EAVAGLVVGL-FTLAALLArpfaGRLLDRFGRKRLLLIGLLIFALAT 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   374 LCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIAdvaFCMGYAIGPSAGGAIAKAIGFPWL 453
Cdd:cd17489  76 LLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLA---TTLAMALGPALGLFLYQHLGFAVL 152

                       170       180
                ....*....|....*....|....
gi 207108   454 MTIIGIIDIAFAPLCFFLRSPPAK 477
Cdd:cd17489 153 FIVAAVLALLALLLVFLVKDPPPV 176
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 300-479 1.69e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 43.70  E-value: 1.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   300 GSICFANMGIAMLEPALPIWMMETMCSrKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFA 379
Cdd:cd17477   3 LSVALLGLGSGLLLPLLSLRLEREGVS-TALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   380 KNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHvsvYGSVYAIADVAFCMGYAIGPsAGGAIAKAIGFPWLMTIIGI 459
Cdd:cd17477  82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN---RGRVLGLYSTVLGLGFALGP-LLLALVGTAGALPFLIAAVL 157

                       170       180
                ....*....|....*....|
gi 207108   460 IDIAFAPLCFFLRSPPAKEE 479
Cdd:cd17477 158 LLLALVPLLLTRRAAPEIEE 177
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 129-460 1.95e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.85  E-value: 1.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   129 NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGML 208
Cdd:cd17333  30 VADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFV 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   209 ASVYtdDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGK-TAPFLVLAALVLLDGAIQLFVLQPSR------VQPESQ 281
Cdd:cd17333 110 GALF--EESSATRLNVLHGFFGLGALIGPLIATSLLTSELSwSWAYLIIGLIYLLLAILILLTLFPELpsarnpQQSVGA 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   282 KGTPLTTLLKDPYILIAAGSIcFANMGIamlEPALPIWMMETMcSRKWQLG---VAFLPAS--ISYLIGTNIFGILAHKM 356
Cdd:cd17333 188 FSASASRLLRNPSIILGALAL-FLYVGA---ETAFSSWVPSYL-VEKKHVSdglAGYLLSGfwVGITIGRLLGGPISRRI 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   357 GRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDLRHVSVYGSVYAIAdvafCMGYAI 436
Cdd:cd17333 263 KPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAG----SIGGAI 338

                       330       340
                ....*....|....*....|....*..
gi 207108   437 GPSAGGAIAKAIG---FPWLMTIIGII 460
Cdd:cd17333 339 IPFIMGFIAEAVGiqtAMLLITILYAI 365
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 295-479 3.44e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.95  E-value: 3.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   295 ILIAAGSICFANMGIAMLEPALPiwmmetMCSRKWQLGVAFLPASIS-YLIGTNI----FGILAHKMGRWLCALLGMVIV 369
Cdd:cd17320   1 LLLLALLVALGPLAIDMYLPALP------AIARDLGASASAVQLTLSaYLLGFALgqllYGPLSDRFGRRPVLLAGLLLF 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   370 GISILCIPFAKNIYGLIAPNF--GVGFAIFMVDSsmmpiMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKA 447
Cdd:cd17320  75 ILASLLCALASSIEQLLIARFlqGLGAAAGSVVA-----RAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLF 149

                       170       180       190
                ....*....|....*....|....*....|....*
gi 207108   448 IGFP---WLMTIIGIidIAFAPLCFFLRSPPAKEE 479
Cdd:cd17320 150 FGWRaifVFLALLGL--LLLLLVLLFLPETLPEEK 182
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 303-471 3.81e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 42.95  E-value: 3.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   303 CFANMGIAMLEPALPIWMMETMCSRKwqlgVAFLPAS---ISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFA 379
Cdd:cd17323   9 FVVTFGSSIYSPALPQIAEDFHVSEE----VANLGVSlfvLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALA 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   380 KNIYGLIAPNFGVGFAIfmvdSSMMPI----MGYLVDLRHVSVYGSVYAIADVAfcmGYAIGPSAGGAIAKAIGFPWLMT 455
Cdd:cd17323  85 PNIAMLIILRFLQGFFG----SSPLAIgagtIADLFTPEERGKAMGVYSLGPLL---GPALGPIIGGFITQSLGWRWIFW 157

                       170
                ....*....|....*.
gi 207108   456 IIGIIDIAFAPLCFFL 471
Cdd:cd17323 158 FLAIISGFCLILIFLF 173
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 325-471 5.80e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 42.31  E-value: 5.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     325 CSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMM 404
Cdd:TIGR00898 123 CEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAV 202

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 207108     405 PIMGYLVDLrhvsvygSVYAIADVAFCMGYAIGPSAGGAIAKAI-GFPWLMTIIGIIDIAFAPLCFFL 471
Cdd:TIGR00898 203 VLNTEFLPK-------KQRAIVGTLIQVFFSLGLVLLPLVAYFIpDWRWLQLAVSLPTFLFFLLSWFV 263
PRK14995 PRK14995
SmvA family efflux MFS transporter;
150-246 6.23e-04

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 42.41  E-value: 6.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108    150 IGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGI----A 225
Cdd:PRK14995  61 MGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVwaavG 140

                         90       100
                 ....*....|....*....|.
gi 207108    226 LGGLAMGVLVGppfGSVLYEF 246
Cdd:PRK14995 141 SGGAAFGPLVG---GILLEHF 158
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 131-248 8.46e-04

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 41.63  E-value: 8.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIG-YPIPMFAGFCI----MFISTVMFAFSSSYAFLLIarslqgIGSSCSSVAGM 205
Cdd:cd17314  39 QIATAASLSNLGMLLTQPILGFIADSFGpRPLMALAGIMVlagyTYLSYVFNSFPLSYACFVF------IGAGTGILYGS 112

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 207108   206 GMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVG 248
Cdd:cd17314 113 AVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYG 155
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 131-253 8.48e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 8.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIgsscssvaGMGMLAS 210
Cdd:cd17370 235 LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL--------YMGAQES 306

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 207108   211 V-------YTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPF 253
Cdd:cd17370 307 IeraavadLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAF 356
PRK05122 PRK05122
major facilitator superfamily transporter; Provisional
 129-248 1.05e-03

major facilitator superfamily transporter; Provisional


Pssm-ID: 235348 [Multi-domain]  Cd Length: 399  Bit Score: 41.41  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108    129 NVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSS--------SYAFLLIARSLQGIGSS-- 198
Cdd:PRK05122  50 AFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLAGllaawpvlSLLLLLLGRLLLGIGESla 129

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 207108    199 --CSSVAGMGMLASVYTddeerGKPM---GIAL-GGLAMGVlvgpPFGSVLYEFVG 248
Cdd:PRK05122 130 gtGSILWGIGRVGALHT-----GRVIswnGIATyGALAIGA----PLGVLLYHWGG 176
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 130-244 2.12e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 2.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   130 VQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAF---SSSYAFLLIARSLQGIGSSCSSVAGMG 206
Cdd:cd17321 204 LQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALlgaDSSVWLLLPGLVLLGLGLGLFATPLTN 283

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 207108   207 MLASVYTDDEergkpMGIALGGLAMGVLVGPPFGSVLY 244
Cdd:cd17321 284 AALSSVPKEK-----AGAASGILNTARQLGGALGVALL 316
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 130-245 2.15e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.29  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   130 VQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAgmGMLA 209
Cdd:cd17390  31 TVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLC--KAYL 108

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 207108   210 SVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYE 245
Cdd:cd17390 109 SDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAE 144
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 129-471 2.18e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 40.36  E-value: 2.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   129 NVQVGLLFASKATVQLLTNPFIGLLTNRIG------YPIPMFAgfcimfISTVMFAFSSSYAFLLIARSLQGIGSSCSSV 202
Cdd:cd17371  33 EAEAGLLGTVTLAGGAIGGILGGILADRFGrvrvlvITILLFA------VFTLLCGFAQNYWQLLILRALAGLGFGGEWA 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   203 AGMGMLASvYTDDEERGKpmgiALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGA--------IQLFVLQPS 274
Cdd:cd17371 107 AGAALMAE-YVPARHRGK----ALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGAlpallvlfIRRFVKEPP 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   275 RVQPESQKGT-----PLTTLLKDPYI----LIAAGSICFANMGIAMLEPALPIWMMETM-CSRKWQLGVAFLPASISYLi 344
Cdd:cd17371 182 QWQAARAARRhfadrPSLRELFSPPLlrttLLASLLATGALGGYYGITTWLPSYLTGERgLSFEGSAGYLVVTILGGFL- 260

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   345 GTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIA-PNFGVGFAIFMVDSSMMPimgYLVDLRHVSVYGSvy 423
Cdd:cd17371 261 GYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILiLGFPLGFFASGPFSGMGA---YLTELFPTAVRAT-- 335

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 207108   424 aiaDVAFCmgYAIGPsAGGAIAKAiGFPWLMTIIGiidIAFAPLCFFL 471
Cdd:cd17371 336 ---AQGFC--YNVGR-IIGALFPF-LVGFLATSGS---LGTAIAVFAA 373
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 131-268 2.46e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.29  E-value: 2.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAgMGMLAS 210
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPA-VQTLVA 315

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 207108   211 VYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQL 268
Cdd:cd17329 316 ALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 148-243 2.46e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 40.44  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108     148 PFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTdDEERGKPMGIalg 227
Cdd:TIGR00711  55 PLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYP-PEKRGRAMAI--- 130

                          90
                  ....*....|....*.
gi 207108     228 gLAMGVLVGPPFGSVL 243
Cdd:TIGR00711 131 -WGLTVLVAPALGPTL 145
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 325-471 2.76e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 39.87  E-value: 2.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   325 CSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIFMVDSSMM 404
Cdd:cd17317  21 CDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGF 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 207108   405 PIMGYLVDLRHVSvygsvyaIADVAFCMGYAIGPSAGGAIAKAIG-FPWLMTIIGIIDIAFAPLCFFL 471
Cdd:cd17317 101 VLGMEIVGPKYRS-------FVGILFGLFWALGYMLLALLAYLIRdWRWLQLAISLPGLLFLLLLWWL 161
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 310-480 3.04e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.85  E-value: 3.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   310 AMLEPALPIwMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPN 389
Cdd:cd17478  13 GFLPALLPL-LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   390 F--GVGFAIFMVDSSmmpIMGYLVDLRHVSVYGSVYAiadVAFCMGYAIGPSAGGAIA---KAIGFPWLMTIIGIIDIAF 464
Cdd:cd17478  92 AlaGIGSAAFHPEGA---RLASQAAGGRRGLAMSIFS---VGGNLGFALGPLIAAALValfGGLGLLILLIIPGLAVALL 165

                       170
                ....*....|....*.
gi 207108   465 APLCFFLRSPPAKEEK 480
Cdd:cd17478 166 LLRLRPLKKPEAKKAA 181
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 132-450 4.16e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.51  E-value: 4.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   132 VGLLFASKATVQLLTNPFIGLLTNR------------IGYPIPMFAGFCIMFiSTVMFAFSSSYAFLLIARSLQGIGSSC 199
Cdd:cd17332  37 AGTIFLVARIIDAINDPLMGYLIDRtrsrwgrfrpwlLWGAIPLALLFVLLF-TTPDGSGTGKLIYALITYILLDLLYTL 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   200 SSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVL-------- 271
Cdd:cd17332 116 VNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLlicffgtr 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   272 QPSRVQPESQKGTPLTTLLK-----DPYILIAAGSICFaNMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISyLIGT 346
Cdd:cd17332 196 ERVVPPEEEKSKLPLLKSLKallknRPFLILLLAYLLY-FLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGA-LLAL 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   347 NIFGILAHKMGRWLCALLGMVIVGISILCIPFAK--NIYGLIAPNFGVGFAIFMVDSSMMPIMGYLVDL----RHVSVYG 420
Cdd:cd17332 274 LPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYgelkTGKRREG 353

                       330       340       350
                ....*....|....*....|....*....|
gi 207108   421 SVYAIADVAFCMGYAIGPSAGGAIAKAIGF 450
Cdd:cd17332 354 IFYSVMTFFRKLGLALAGALVGLILSLAGY 383
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 130-227 4.98e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.10  E-value: 4.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   130 VQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAF-SSSYAFLLIARSLQGIGSSCSSVAGMGML 208
Cdd:cd17504 217 TEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIV 296

                        90
                ....*....|....*....
gi 207108   209 asVYTDDEERgkpMGIALG 227
Cdd:cd17504 297 --VESVPPDR---TGIATG 310
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 340-471 5.40e-03

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 39.15  E-value: 5.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   340 ISYLIGTNIFGILAHKMG--RWLCALlgMVIVGISILCIPFAKNIYGLIAPNFGVGfaifMVDSSMMPIMGYLVdlrhvs 417
Cdd:cd17327  52 VGYIIFELPGNLLLQRFPpsKWLSVF--IVLWGLLTLLTAAVKNFGGLIALRFFLG----LFESGVFPGFILYL------ 119

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 207108   418 vyGSVYAIADVAFCMGY-----AIGPSAGGAIAKAI----------GFPWLMTIIGIIDIAFAPLCFFL 471
Cdd:cd17327 120 --GMWYKREEQAKRIAFfyaaaGLGSIFGGLLAYGVfkilgvgglaGWRWLFIIEGLITIIIGLVIFFW 186
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 341-471 6.70e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 38.70  E-value: 6.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   341 SYLIGTN----IFGILAHKMGRWLCALLGMVIVGI-SILCiPFAKNIYGLIAPNF--GVGFAIFMvdSSMMPIMGYLVDL 413
Cdd:cd17502  38 AYLLTSTafqpIYGKLSDLFGRKWVLLIAIVIFELgSLLC-GLAPNMTMLIVGRAiqGIGGGGLM--SLAFIIIADLVPP 114

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 207108   414 RHVSVY----GSVYAIADVAfcmgyaiGPSAGGAIAKAIGFPWLMTI---IGIIDIAFAPLCFFL 471
Cdd:cd17502 115 RERGKYqgyiGAVFGIASVA-------GPLIGGAFTDHLSWRWCFYInlpIGGLALALLRTILLS 172
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 305-471 7.91e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 38.71  E-value: 7.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   305 ANMGIAMLEpalpiwMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMG--RWLcaLLGMVIVGISILCIPFAKNI 382
Cdd:cd17319  20 VNISVAAPT------IMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGarKVL--AVSMLLWSLFTALTGFATSL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   383 YGLIAPNFGVGFAifmvDSSMMPIMGYLVDLRH-VSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIID 461
Cdd:cd17319  92 TSLYVLRFLLGVA----EAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLG 167

                       170
                ....*....|
gi 207108   462 IAFAPLCFFL 471
Cdd:cd17319 168 LLLAVLWWFY 177
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 131-236 9.30e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.37  E-value: 9.30e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   131 QVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGmGMLAS 210
Cdd:cd17475  32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGG-GRAIM 110

                        90       100
                ....*....|....*....|....*.
gi 207108   211 VYTDDEERGKPMGIALGGLAMGVLVG 236
Cdd:cd17475 111 RWFPPRERGLAMGIRQTGVPLGGALA 136
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 142-451 9.91e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 38.35  E-value: 9.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   142 VQLLTNPFIGLLTNRIGypiPMFAgFCIMFISTV----MFAFSSSYAFLLIARsLQGIGSSCSSVAGMgmLASVYTDDEE 217
Cdd:cd17331  47 LQLVGGPLFGRFGDLFG---PRAA-LVLSFLSSAlsylLLAFASSVPMLFLSR-LPSVFMHAMQAAQM--VVTDLTDPGE 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   218 RGKpmgiALGGL----AMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVL------QPSRVQPESQKG---- 283
Cdd:cd17331 120 RAA----ALGRLglsyGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIpsntksKREKEAKESASPpsvf 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   284 --TPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGvAFLPASISYLIGTNIF--GILAHKMGRW 359
Cdd:cd17331 196 nlKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENG-YLMSYAGVLGMVVQGLlvGPLTKRFGER 274

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 207108   360 LCALLGMVIVGISILCIPFAKNIYG--LIAPNFGVGFAIFMVDSSMMpimgyLVDLRHVSVYGSVYAIADVAFCMGYAIG 437
Cdd:cd17331 275 SLLKLSVALLAIGYLLLAFVTTVWQllVLLLPLVIGGSVLYTVITSL-----LTKAVPPEDTGTALGLSHALFSLVRTVS 349

                       330
                ....*....|....
gi 207108   438 PSAGGAIAKAIGFP 451
Cdd:cd17331 350 PTIGGALLQAYGFP 363
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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