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Conserved domains on  [gi|529233|gb|AAA53106|]
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glucose-6-phosphate dehydrogenase, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05096 super family cl35283
guanosine 5'-monophosphate oxidoreductase; Provisional
 1-40 1.24e-19

guanosine 5'-monophosphate oxidoreductase; Provisional


The actual alignment was detected with superfamily member PRK05096:

Pssm-ID: 235343 [Multi-domain]  Cd Length: 346  Bit Score: 78.06  E-value: 1.24e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 529233      1 VDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQ 40
Cdd:PRK05096  29 VELERQFTFKHSGQSWSGVPIIAANMDTVGTFEMAKALAS 68
 
Name Accession Description Interval E-value
PRK05096 PRK05096
guanosine 5'-monophosphate oxidoreductase; Provisional
 1-40 1.24e-19

guanosine 5'-monophosphate oxidoreductase; Provisional


Pssm-ID: 235343 [Multi-domain]  Cd Length: 346  Bit Score: 78.06  E-value: 1.24e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 529233      1 VDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQ 40
Cdd:PRK05096  29 VELERQFTFKHSGQSWSGVPIIAANMDTVGTFEMAKALAS 68
IMPDH cd00381
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the ...
 1-40 2.07e-06

IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine nucleotides. There is often a CBS domain inserted in the middle of this domain, which is proposed to play a regulatory role. IMPDH is a key enzyme in the regulation of cell proliferation and differentiation. It has been identified as an attractive target for developing chemotherapeutic agents.


Pssm-ID: 238223 [Multi-domain]  Cd Length: 325  Bit Score: 41.35  E-value: 2.07e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 529233     1 VDLERTFTfrnsKQTYSGIPIIVANMDTVGTFEMAAVMSQ 40
Cdd:cd00381  21 VDLSTKLT----KNITLNIPLVSAPMDTVTESEMAIAMAR 56
IMPDH pfam00478
IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine ...
 19-40 3.72e-03

IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.


Pssm-ID: 459826 [Multi-domain]  Cd Length: 463  Bit Score: 31.98  E-value: 3.72e-03
                          10        20
                  ....*....|....*....|..
gi 529233      19 IPIIVANMDTVGTFEMAAVMSQ 40
Cdd:pfam00478  35 IPLVSAAMDTVTEARMAIAMAR 56
 
Name Accession Description Interval E-value
PRK05096 PRK05096
guanosine 5'-monophosphate oxidoreductase; Provisional
 1-40 1.24e-19

guanosine 5'-monophosphate oxidoreductase; Provisional


Pssm-ID: 235343 [Multi-domain]  Cd Length: 346  Bit Score: 78.06  E-value: 1.24e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 529233      1 VDLERTFTFRNSKQTYSGIPIIVANMDTVGTFEMAAVMSQ 40
Cdd:PRK05096  29 VELERQFTFKHSGQSWSGVPIIAANMDTVGTFEMAKALAS 68
IMPDH cd00381
IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the ...
 1-40 2.07e-06

IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine nucleotides. There is often a CBS domain inserted in the middle of this domain, which is proposed to play a regulatory role. IMPDH is a key enzyme in the regulation of cell proliferation and differentiation. It has been identified as an attractive target for developing chemotherapeutic agents.


Pssm-ID: 238223 [Multi-domain]  Cd Length: 325  Bit Score: 41.35  E-value: 2.07e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 529233     1 VDLERTFTfrnsKQTYSGIPIIVANMDTVGTFEMAAVMSQ 40
Cdd:cd00381  21 VDLSTKLT----KNITLNIPLVSAPMDTVTESEMAIAMAR 56
IMPDH pfam00478
IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine ...
 19-40 3.72e-03

IMP dehydrogenase / GMP reductase domain; This family is involved in biosynthesis of guanosine nucleotide. Members of this family contain a TIM barrel structure. In the inosine monophosphate dehydrogenases 2 CBS domains pfam00571 are inserted in the TIM barrel. This family is a member of the common phosphate binding site TIM barrel family.


Pssm-ID: 459826 [Multi-domain]  Cd Length: 463  Bit Score: 31.98  E-value: 3.72e-03
                          10        20
                  ....*....|....*....|..
gi 529233      19 IPIIVANMDTVGTFEMAAVMSQ 40
Cdd:pfam00478  35 IPLVSAAMDTVTEARMAIAMAR 56
PTZ00314 PTZ00314
inosine-5'-monophosphate dehydrogenase; Provisional
 19-38 8.45e-03

inosine-5'-monophosphate dehydrogenase; Provisional


Pssm-ID: 240355 [Multi-domain]  Cd Length: 495  Bit Score: 31.09  E-value: 8.45e-03
                         10        20
                 ....*....|....*....|
gi 529233     19 IPIIVANMDTVGTFEMAAVM 38
Cdd:PTZ00314  51 IPIVSSPMDTVTEHKMAIAM 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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