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Conserved domains on  [gi|183951|gb|AAA58636|]
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heparin binding protein [Homo sapiens]

Protein Classification

fibroblast growth factor-binding protein( domain architecture ID 10534429)

fibroblast growth factor-binding protein (FGF-BP) acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FGF-BP1 pfam06473
FGF binding protein 1 (FGF-BP1); This family consists of several mammalian FGF binding protein ...
 22-231 1.73e-86

FGF binding protein 1 (FGF-BP1); This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development. Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2.


:

Pssm-ID: 461927 [Multi-domain]  Cd Length: 229  Bit Score: 255.75  E-value: 1.73e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183951      22 EGKKKVKNGLHSKVvseqkdtlgnTQIKQKSRPGN---KGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAG 98
Cdd:pfam06473  15 KGKKGAKNKKGSQA----------PQQKQRSKGGKsgeSGKFVTKDQASCTWAVSEQEEGITLRVECTGQGNRYWCEFAG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183951      99 NPTSCLKL-KDERVYWKQVARNLRSQKDICRYSKTaVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKG- 176
Cdd:pfam06473  85 NPTLCLAYaANPKHYWKQVLRELRKQKNACQDPKV-LKTRVCRKAPPEAHLKLVNSSLASSVKPEKERSKPSPREPTKGp 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 183951     177 ----------KETTPSSLAVTQTMATKAPECVE-DPDMANQRKTALEFCGETWSSLCTFFLSIVQD 231
Cdd:pfam06473 164 tavsvepksvKKTKKGKPKATQTPAQKGPECVEpDPDLIEQRKLAEEYCGESWHSLCNFFITFFQG 229
 
Name Accession Description Interval E-value
FGF-BP1 pfam06473
FGF binding protein 1 (FGF-BP1); This family consists of several mammalian FGF binding protein ...
 22-231 1.73e-86

FGF binding protein 1 (FGF-BP1); This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development. Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2.


Pssm-ID: 461927 [Multi-domain]  Cd Length: 229  Bit Score: 255.75  E-value: 1.73e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183951      22 EGKKKVKNGLHSKVvseqkdtlgnTQIKQKSRPGN---KGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAG 98
Cdd:pfam06473  15 KGKKGAKNKKGSQA----------PQQKQRSKGGKsgeSGKFVTKDQASCTWAVSEQEEGITLRVECTGQGNRYWCEFAG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183951      99 NPTSCLKL-KDERVYWKQVARNLRSQKDICRYSKTaVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKG- 176
Cdd:pfam06473  85 NPTLCLAYaANPKHYWKQVLRELRKQKNACQDPKV-LKTRVCRKAPPEAHLKLVNSSLASSVKPEKERSKPSPREPTKGp 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 183951     177 ----------KETTPSSLAVTQTMATKAPECVE-DPDMANQRKTALEFCGETWSSLCTFFLSIVQD 231
Cdd:pfam06473 164 tavsvepksvKKTKKGKPKATQTPAQKGPECVEpDPDLIEQRKLAEEYCGESWHSLCNFFITFFQG 229
 
Name Accession Description Interval E-value
FGF-BP1 pfam06473
FGF binding protein 1 (FGF-BP1); This family consists of several mammalian FGF binding protein ...
 22-231 1.73e-86

FGF binding protein 1 (FGF-BP1); This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during fetal and embryonic development. Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2.


Pssm-ID: 461927 [Multi-domain]  Cd Length: 229  Bit Score: 255.75  E-value: 1.73e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183951      22 EGKKKVKNGLHSKVvseqkdtlgnTQIKQKSRPGN---KGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAG 98
Cdd:pfam06473  15 KGKKGAKNKKGSQA----------PQQKQRSKGGKsgeSGKFVTKDQASCTWAVSEQEEGITLRVECTGQGNRYWCEFAG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183951      99 NPTSCLKL-KDERVYWKQVARNLRSQKDICRYSKTaVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKG- 176
Cdd:pfam06473  85 NPTLCLAYaANPKHYWKQVLRELRKQKNACQDPKV-LKTRVCRKAPPEAHLKLVNSSLASSVKPEKERSKPSPREPTKGp 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 183951     177 ----------KETTPSSLAVTQTMATKAPECVE-DPDMANQRKTALEFCGETWSSLCTFFLSIVQD 231
Cdd:pfam06473 164 tavsvepksvKKTKKGKPKATQTPAQKGPECVEpDPDLIEQRKLAEEYCGESWHSLCNFFITFFQG 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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