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Conserved domains on  [gi|189656|gb|AAA60033|]
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pyruvate carboxylase, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PycA super family cl43313
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 1-43 7.40e-15

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


The actual alignment was detected with superfamily member COG1038:

Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 65.49  E-value: 7.40e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 189656      1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI 43
Cdd:COG1038 1102 DPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVEAGDLLIEL 1144
 
Name Accession Description Interval E-value
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 1-43 7.40e-15

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 65.49  E-value: 7.40e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 189656      1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI 43
Cdd:COG1038 1102 DPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVEAGDLLIEL 1144
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 1-44 1.44e-14

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 64.39  E-value: 1.44e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 189656       1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 44
Cdd:PRK12999 1102 DPLAVIEAMKMETTITAPVDGTVKRVLVKAGDQVEAGDLLVELE 1145
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 1-43 1.28e-11

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 52.42  E-value: 1.28e-11
                       10        20        30        40
               ....*....|....*....|....*....|....*....|...
gi 189656    1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI 43
Cdd:cd06850 25 QPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 1-43 4.59e-09

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 46.05  E-value: 4.59e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 189656      1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI 43
Cdd:pfam00364 31 QPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
 
Name Accession Description Interval E-value
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 1-43 7.40e-15

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 65.49  E-value: 7.40e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 189656      1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI 43
Cdd:COG1038 1102 DPLLTIEAMKMETTITAPRDGTVKEVLVKEGDQVEAGDLLIEL 1144
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 1-44 1.44e-14

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 64.39  E-value: 1.44e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 189656       1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 44
Cdd:PRK12999 1102 DPLAVIEAMKMETTITAPVDGTVKRVLVKAGDQVEAGDLLVELE 1145
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 1-43 1.28e-11

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 52.42  E-value: 1.28e-11
                       10        20        30        40
               ....*....|....*....|....*....|....*....|...
gi 189656    1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI 43
Cdd:cd06850 25 QPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 1-43 4.59e-09

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 46.05  E-value: 4.59e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 189656      1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI 43
Cdd:pfam00364 31 QPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 1-44 1.12e-08

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 47.91  E-value: 1.12e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 189656      1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 44
Cdd:PRK09282 548 DTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIE 591
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 1-44 5.82e-08

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 44.89  E-value: 5.82e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 189656     1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 44
Cdd:COG0511  93 DTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 1-40 1.16e-06

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 41.34  E-value: 1.16e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 189656      1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLE-GDDLI 40
Cdd:PRK06549  87 QPLLILEAMKMENEIVASSAGTVTAIHVTPGQVVNpGDGLI 127
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
3-37 1.81e-04

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 36.06  E-value: 1.81e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 189656      3 LCVLSAMKMETVVTSPMEGTVRKVHVTkdmtlEGD 37
Cdd:PRK14040 552 LLILEAMKMETEIRAAQAGTVRGIAVK-----EGD 581
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 1-43 3.96e-04

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 34.84  E-value: 3.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 189656      1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEI 43
Cdd:PRK05641 110 QGLLILEAMKMENEIPAPKDGVVKKILVKEGDTVDTGQPLIEL 152
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 1-44 6.85e-03

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 30.53  E-value: 6.85e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 189656     1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTK-DMTLEGDDLiLEIE 44
Cdd:PRK08225 27 QDVVILESMKMEIPIVAEEAGTVKKINVQEgDFVNEGDVL-LEIE 70
aceF PRK11854
pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated
 1-44 8.03e-03

pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated


Pssm-ID: 236999 [Multi-domain]  Cd Length: 633  Bit Score: 31.51  E-value: 8.03e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 189656      1 QPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLEGDDLILEIE 44
Cdd:PRK11854  32 QSLITVEGDKASMEVPSPQAGVVKEIKVKVGDKVETGALIMIFE 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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