T-cell receptor CD3 theta subunit [Mus sp.]
Protein Classification
TCR_zetazeta and ITAM domain-containing protein( domain architecture ID 10569225)
TCR_zetazeta and ITAM domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| TCR_zetazeta | pfam11628 | T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling ... |
28-58 | 9.07e-16 | ||
T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR. : Pssm-ID: 463313 Cd Length: 31 Bit Score: 67.34 E-value: 9.07e-16
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| ITAM super family | cl02452 | Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ... |
69-89 | 3.81e-04 | ||
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery. The actual alignment was detected with superfamily member smart00077: Pssm-ID: 128390 Cd Length: 21 Bit Score: 36.21 E-value: 3.81e-04
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| Name | Accession | Description | Interval | E-value | ||
| TCR_zetazeta | pfam11628 | T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling ... |
28-58 | 9.07e-16 | ||
T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR. Pssm-ID: 463313 Cd Length: 31 Bit Score: 67.34 E-value: 9.07e-16
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| ITAM | smart00077 | Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ... |
69-89 | 3.81e-04 | ||
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery. Pssm-ID: 128390 Cd Length: 21 Bit Score: 36.21 E-value: 3.81e-04
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| ITAM | pfam02189 | Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ... |
69-86 | 7.25e-03 | ||
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains. Pssm-ID: 426646 Cd Length: 20 Bit Score: 32.74 E-value: 7.25e-03
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| Name | Accession | Description | Interval | E-value | ||
| TCR_zetazeta | pfam11628 | T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling ... |
28-58 | 9.07e-16 | ||
T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR. Pssm-ID: 463313 Cd Length: 31 Bit Score: 67.34 E-value: 9.07e-16
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| ITAM | smart00077 | Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ... |
69-89 | 3.81e-04 | ||
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery. Pssm-ID: 128390 Cd Length: 21 Bit Score: 36.21 E-value: 3.81e-04
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| ITAM | pfam02189 | Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ... |
69-86 | 7.25e-03 | ||
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains. Pssm-ID: 426646 Cd Length: 20 Bit Score: 32.74 E-value: 7.25e-03
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