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Conserved domains on  [gi|836885|gb|AAB52516|]
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sel-1-like protein [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
2-57 4.33e-13

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 62.25  E-value: 4.33e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 836885     2 GLDTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:COG0790  76 GRGVPKDYEKALEWFEKAAEQGD-AEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
2-57 4.33e-13

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 62.25  E-value: 4.33e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 836885     2 GLDTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:COG0790  76 GRGVPKDYEKALEWFEKAAEQGD-AEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 26-57 5.03e-09

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 47.13  E-value: 5.03e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 836885     26 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:pfam08238  1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAA 32
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 26-57 7.21e-09

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.78  E-value: 7.21e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 836885      26 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:smart00671  1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAA 32
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
2-57 4.33e-13

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 62.25  E-value: 4.33e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 836885     2 GLDTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:COG0790  76 GRGVPKDYEKALEWFEKAAEQGD-AEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130
TPR COG0790
TPR repeat [General function prediction only];
2-57 9.37e-13

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 61.10  E-value: 9.37e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 836885     2 GLDTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:COG0790 112 GLGVPQDYAKALEWYEKAAEQGD-ADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAA 166
TPR COG0790
TPR repeat [General function prediction only];
2-57 1.30e-12

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 60.71  E-value: 1.30e-12
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 836885     2 GLDTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:COG0790 148 GEGVPKDPAKAAEWYRKAAEQGD-ADAQYNLGVLYENGRGVPKDPAKALEWYRKAA 202
TPR COG0790
TPR repeat [General function prediction only];
2-57 4.66e-10

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 53.78  E-value: 4.66e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 836885     2 GLDTDVDYETAFIHYRLASEQQHsAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:COG0790 184 GRGVPKDPAKALEWYRKAAEQGD-ADAQYNLGRLYLNGEGVEKDLEKALRWLRKAA 238
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 26-57 5.03e-09

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 47.13  E-value: 5.03e-09
                         10        20        30
                 ....*....|....*....|....*....|..
gi 836885     26 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:pfam08238  1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAA 32
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 26-57 7.21e-09

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.78  E-value: 7.21e-09
                          10        20        30
                  ....*....|....*....|....*....|..
gi 836885      26 AQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:smart00671  1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAA 32
TPR COG0790
TPR repeat [General function prediction only];
1-57 7.92e-06

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 42.22  E-value: 7.92e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 836885     1 MGLDTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAA 57
Cdd:COG0790  38 AAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAA 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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