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Conserved domains on  [gi|2621190|gb|AAB84655|]
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molybdenum cofactor biosynthesis protein MoaE [Methanothermobacter thermautotrophicus str. Delta H]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 28-135 2.56e-32

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


:

Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 110.68  E-value: 2.56e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190   28 DECGAIFTFEGIVRGVDD-KRIDKLVLTTPDtERAQIELEGIVEDVRRKYPVRDVAVVHYLGEFYTSETLFMVAVAGPHR 106
Cdd:cd00756  13 PEAGAVVTFVGTVRDHDEgKGVEALEYEAYP-PMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEAIVLVAVSSPHR 91

                        90       100
                ....*....|....*....|....*....
gi 2621190  107 EETLKALSEIIERTKHEIEFKKEEYTDSG 135
Cdd:cd00756  92 KEAFEACEFLIDRLKHRAPIWKKEIFEGG 120
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 28-135 2.56e-32

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 110.68  E-value: 2.56e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190   28 DECGAIFTFEGIVRGVDD-KRIDKLVLTTPDtERAQIELEGIVEDVRRKYPVRDVAVVHYLGEFYTSETLFMVAVAGPHR 106
Cdd:cd00756  13 PEAGAVVTFVGTVRDHDEgKGVEALEYEAYP-PMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEAIVLVAVSSPHR 91

                        90       100
                ....*....|....*....|....*....
gi 2621190  107 EETLKALSEIIERTKHEIEFKKEEYTDSG 135
Cdd:cd00756  92 KEAFEACEFLIDRLKHRAPIWKKEIFEGG 120
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 1-135 3.95e-32

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 111.04  E-value: 3.95e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190    1 MIVRVTDEkeAYRMEDLIENLKKSPylDECGAIFTFEGIVRGVDD-KRIDKLVLTT--PDTERaqiELEGIVEDVRRKYP 77
Cdd:COG0314   2 MRVRVTEE--PFDLAAELAALRASD--PEAGAVVTFVGTVRDHNDgRRVTALEYEAypPMAEK---ELAEIAEEAAERWG 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 2621190   78 VRDVAVVHYLGEFYTSETLFMVAVAGPHREETLKALSEIIERTKHEIEFKKEEYTDSG 135
Cdd:COG0314  75 LLDVAVIHRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDG 132
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 18-123 9.24e-26

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 93.67  E-value: 9.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190     18 IENLKKSPyldECGAIFTFEGIVRGVDD-KRIDKLVLT--TPDTERaqiELEGIVEDVRRKYPVRDVAVVHYLGEFYTSE 94
Cdd:pfam02391  11 IAALVSDP---EAGAVVTFVGTVRDHFDgKKVTALEYEayPPMAEK---ELAEIAEEARERWPLLDVAIVHRVGRLPVGE 84

                          90       100
                  ....*....|....*....|....*....
gi 2621190     95 TLFMVAVAGPHREETLKALSEIIERTKHE 123
Cdd:pfam02391  85 AIVLVAVSSPHRAEAFEACEYLIDELKAR 113
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 28-133 1.12e-13

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 62.78  E-value: 1.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190    28 DECGAIFTFEGIVRG-VDDKRIDKLVLT--TPDTERaqiELEGIVEDVRRKYPVRDVAVVHYLGEFYTSETLFMVAVAGP 104
Cdd:PLN02390   2 PQAGAIATFSGTTRDtFEGKTVLELRYEayVPMALR---ELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSV 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 2621190   105 HREETLKALSEIIERTKHEIE-FKKEEYTD 133
Cdd:PLN02390  79 HRADALDACKFLIDELKASVPiWKKEVYDD 108
 
Name Accession Description Interval E-value
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 28-135 2.56e-32

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 110.68  E-value: 2.56e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190   28 DECGAIFTFEGIVRGVDD-KRIDKLVLTTPDtERAQIELEGIVEDVRRKYPVRDVAVVHYLGEFYTSETLFMVAVAGPHR 106
Cdd:cd00756  13 PEAGAVVTFVGTVRDHDEgKGVEALEYEAYP-PMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEAIVLVAVSSPHR 91

                        90       100
                ....*....|....*....|....*....
gi 2621190  107 EETLKALSEIIERTKHEIEFKKEEYTDSG 135
Cdd:cd00756  92 KEAFEACEFLIDRLKHRAPIWKKEIFEGG 120
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 1-135 3.95e-32

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 111.04  E-value: 3.95e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190    1 MIVRVTDEkeAYRMEDLIENLKKSPylDECGAIFTFEGIVRGVDD-KRIDKLVLTT--PDTERaqiELEGIVEDVRRKYP 77
Cdd:COG0314   2 MRVRVTEE--PFDLAAELAALRASD--PEAGAVVTFVGTVRDHNDgRRVTALEYEAypPMAEK---ELAEIAEEAAERWG 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 2621190   78 VRDVAVVHYLGEFYTSETLFMVAVAGPHREETLKALSEIIERTKHEIEFKKEEYTDSG 135
Cdd:COG0314  75 LLDVAVIHRVGRLEPGEPIVLVAVSSAHRKEAFEACRFLIDRLKTRAPIWKKEIFEDG 132
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 18-123 9.24e-26

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 93.67  E-value: 9.24e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190     18 IENLKKSPyldECGAIFTFEGIVRGVDD-KRIDKLVLT--TPDTERaqiELEGIVEDVRRKYPVRDVAVVHYLGEFYTSE 94
Cdd:pfam02391  11 IAALVSDP---EAGAVVTFVGTVRDHFDgKKVTALEYEayPPMAEK---ELAEIAEEARERWPLLDVAIVHRVGRLPVGE 84

                          90       100
                  ....*....|....*....|....*....
gi 2621190     95 TLFMVAVAGPHREETLKALSEIIERTKHE 123
Cdd:pfam02391  85 AIVLVAVSSPHRAEAFEACEYLIDELKAR 113
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 28-133 1.12e-13

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 62.78  E-value: 1.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190    28 DECGAIFTFEGIVRG-VDDKRIDKLVLT--TPDTERaqiELEGIVEDVRRKYPVRDVAVVHYLGEFYTSETLFMVAVAGP 104
Cdd:PLN02390   2 PQAGAIATFSGTTRDtFEGKTVLELRYEayVPMALR---ELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSV 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 2621190   105 HREETLKALSEIIERTKHEIE-FKKEEYTD 133
Cdd:PLN02390  79 HRADALDACKFLIDELKASVPiWKKEVYDD 108
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 2-129 3.30e-12

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 61.94  E-value: 3.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190     2 IVRVTDEKEAYR-MEDLIENLKKSPYLDECGAIFTFEGIVRGV---DDKRIDKLVLTTPDTErAQIELEGIVEDVRRKYP 77
Cdd:PRK14493 130 LVAALESQPPYVtLESLVAKVKRSPDADKAGAIATFTGRVRAKedaDDEPTEYLEFEKYDGV-ADERMAAIREELKQRDG 208

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 2621190    78 VRDVAVVHYLGEFYTSETLFMVAVAGPHREETLKALSEIIERTKHEIE-FKKE 129
Cdd:PRK14493 209 VFEVLLHHRTGVIEAGEDIVFVVVLAGHRQEAFRAVSDGIDRLKDEVPiFKKE 261
moaE PRK10678
molybdopterin synthase catalytic subunit MoaE;
28-135 2.71e-10

molybdopterin synthase catalytic subunit MoaE;


Pssm-ID: 182642  Cd Length: 150  Bit Score: 54.75  E-value: 2.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2621190    28 DECGAIFTFEGIVRGVD-DKRIDKLVLT-TPD-TERAqieLEGIVEDVRRKYPVRDVAVVHYLGEFYTSETLFMVAVAGP 104
Cdd:PRK10678  26 DEDGAVVTFTGKVRNHNlGDSVKALTLEhYPGmTEKA---LAEIVDEARSRWPLGRVTVIHRVGELWPGDEIVFVGVTSA 102

                         90       100       110
                 ....*....|....*....|....*....|.
gi 2621190   105 HREETLKALSEIIERTKHEIEFKKEEYTDSG 135
Cdd:PRK10678 103 HRSSAFEAGQFIMDYLKTRAPFWKREATPEG 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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