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Conserved domains on  [gi|2707593|gb|AAB92353|]
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protoporhyrinogen oxidase, partial [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HemY super family cl34197
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 16-45 3.52e-06

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


The actual alignment was detected with superfamily member COG1232:

Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 40.97  E-value: 3.52e-06
                        10        20        30
                ....*....|....*....|....*....|
gi 2707593   16 LTLAGASYEGVAVNDCIESGRQAAVAVLGT 45
Cdd:COG1232 413 LYLAGRAYDGVGLPDCIRSGREAAERILAE 442
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 16-45 3.52e-06

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 40.97  E-value: 3.52e-06
                        10        20        30
                ....*....|....*....|....*....|
gi 2707593   16 LTLAGASYEGVAVNDCIESGRQAAVAVLGT 45
Cdd:COG1232 413 LYLAGRAYDGVGLPDCIRSGREAAERILAE 442
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 16-44 3.88e-06

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 40.99  E-value: 3.88e-06
                         10        20
                 ....*....|....*....|....*....
gi 2707593    16 LTLAGASYEGVAVNDCIESGRQAAVAVLG 44
Cdd:PRK11883 422 LYVAGASFEGVGLPDCIAQAKRAAARLLA 450
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 16-43 2.82e-03

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 32.89  E-value: 2.82e-03
                          10        20
                  ....*....|....*....|....*...
gi 2707593     16 LTLAGASYEGVAVNDCIESGRQAAVAVL 43
Cdd:TIGR00562 430 VFLTGNSFEGVGIPDCIDQGKAAASDVL 457
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 16-45 3.52e-06

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 40.97  E-value: 3.52e-06
                        10        20        30
                ....*....|....*....|....*....|
gi 2707593   16 LTLAGASYEGVAVNDCIESGRQAAVAVLGT 45
Cdd:COG1232 413 LYLAGRAYDGVGLPDCIRSGREAAERILAE 442
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 16-44 3.88e-06

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 40.99  E-value: 3.88e-06
                         10        20
                 ....*....|....*....|....*....
gi 2707593    16 LTLAGASYEGVAVNDCIESGRQAAVAVLG 44
Cdd:PRK11883 422 LYVAGASFEGVGLPDCIAQAKRAAARLLA 450
PRK12416 PRK12416
protoporphyrinogen oxidase; Provisional
 16-45 2.38e-04

protoporphyrinogen oxidase; Provisional


Pssm-ID: 183516  Cd Length: 463  Bit Score: 35.96  E-value: 2.38e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 2707593    16 LTLAGASYEGVAVNDCIESGRQAAVAVLGT 45
Cdd:PRK12416 431 IYLAGASYYGVGIGACIGNGKNTANEIIAT 460
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 16-43 2.82e-03

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 32.89  E-value: 2.82e-03
                          10        20
                  ....*....|....*....|....*...
gi 2707593     16 LTLAGASYEGVAVNDCIESGRQAAVAVL 43
Cdd:TIGR00562 430 VFLTGNSFEGVGIPDCIDQGKAAASDVL 457
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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