NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|3005702|gb|AAC09350|]
View 

unknown [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 38-290 3.25e-160

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


:

Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 460.61  E-value: 3.25e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   38 FQYTPDHVVGPGADIDPTQITFPGCICVKTPCLPGTCSCLRH-GENYDDNSCLRDIGSggKYAEPVFECNVLCRCSDHCR 116
Cdd:cd10544   3 FQYTPENVPGPGADTDPNEITFPGCDCKTSSCEPETCSCLRKyGPNYDDDGCLLDFDG--KYSGPVFECNSMCKCSESCQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  117 NRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETF 196
Cdd:cd10544  81 NRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYIIVLREHLSSGKVLETF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  197 VDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYC 276
Cdd:cd10544 161 VDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVPKLALFAARDIVAGEELSFDYSGEFSNSVESVTLARQDESKSRKPCLC 240

                       250
                ....*....|....
gi 3005702  277 GAKSCTAFLPFDSS 290
Cdd:cd10544 241 GAENCRGFLPFDES 254
Transposase_1 pfam01359
Transposase (partial DDE domain); This family includes the mariner transposase.
 488-567 7.28e-33

Transposase (partial DDE domain); This family includes the mariner transposase.


:

Pssm-ID: 460174  Cd Length: 80  Bit Score: 121.26  E-value: 7.28e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702    488 LYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNR 567
Cdd:pfam01359   1 LYENKRRSAQWVDAGEPPKKVPKPELHAKKVMLSVWWDAKGVLYVELLPPGKTINAEYYASQLRKLRQALKEKRPGKVRV 80
transpos_IS630 super family cl41314
IS630 family transposase;
370-642 8.33e-16

IS630 family transposase;


The actual alignment was detected with superfamily member NF033545:

Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 78.45  E-value: 8.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   370 ERTVQWWFKKFCK-GDESLEDEERSGRPSEVDNDQ----LRAIIEADPLT----TTREVAEELN------VNHSTVVRHL 434
Cdd:NF033545  26 RSTVYRWLKRFNEgGLEGLLDKPRPGRPRKLLSEQqaelLALLLEEPPEGaghwTLRELAALLEeefgveYSRSTVRRLL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   435 KQIG-KVKKLDKWvPHELTENQKNRRFEVssslILRNHNEPFLDRIVTCDEKWI-LYDNRRRSaqWldqeeAPKHFPKPI 512
Cdd:NF033545 106 KRLGlSPKKPRPR-APKQDPEFVEKFKEV----LGLYRAPPDPAEVVFIDESGIqLLDTRGRG--W-----APKGQRRPR 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   513 LHPKKVmvtiwWSAAGLihYSFLNP--GETITSEKYAQEIDEMNQKLQRLqLALVNRKGPILLHDNARPHVAQPTLQKLN 590
Cdd:NF033545 174 VHVYGR-----RGTLNL--FGALDPltGKVFVLFTGRINSEDFIEFLEEL-LAAYPGKKIHLILDNASTHKSKKVREWLE 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 3005702   591 ELGY-EVLPHPPYSPDLLPTNYhVFKHLN-NFLQGKRFHNQQDAENAFQEFVES 642
Cdd:NF033545 246 EHGRiELHYLPPYSPWLNPIER-VWAVLKrRLLRNRAFRSVDELREAIDAFLNR 298
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 335-384 1.72e-14

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


:

Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 67.93  E-value: 1.72e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 3005702    335 KKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGD 384
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRSGD 50
 
Name Accession Description Interval E-value
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 38-290 3.25e-160

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 460.61  E-value: 3.25e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   38 FQYTPDHVVGPGADIDPTQITFPGCICVKTPCLPGTCSCLRH-GENYDDNSCLRDIGSggKYAEPVFECNVLCRCSDHCR 116
Cdd:cd10544   3 FQYTPENVPGPGADTDPNEITFPGCDCKTSSCEPETCSCLRKyGPNYDDDGCLLDFDG--KYSGPVFECNSMCKCSESCQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  117 NRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETF 196
Cdd:cd10544  81 NRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYIIVLREHLSSGKVLETF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  197 VDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYC 276
Cdd:cd10544 161 VDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVPKLALFAARDIVAGEELSFDYSGEFSNSVESVTLARQDESKSRKPCLC 240

                       250
                ....*....|....
gi 3005702  277 GAKSCTAFLPFDSS 290
Cdd:cd10544 241 GAENCRGFLPFDES 254
Transposase_1 pfam01359
Transposase (partial DDE domain); This family includes the mariner transposase.
 488-567 7.28e-33

Transposase (partial DDE domain); This family includes the mariner transposase.


Pssm-ID: 460174  Cd Length: 80  Bit Score: 121.26  E-value: 7.28e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702    488 LYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNR 567
Cdd:pfam01359   1 LYENKRRSAQWVDAGEPPKKVPKPELHAKKVMLSVWWDAKGVLYVELLPPGKTINAEYYASQLRKLRQALKEKRPGKVRV 80
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 126-255 1.24e-32

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 122.06  E-value: 1.24e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702     126 FHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHL--QTKSDSNYIIAIREHVYngqvmetfVDPTYIG 203
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAydTDGAKAFYLFDIDSDLC--------IDARRKG 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 3005702     204 NIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYSGRYLN 255
Cdd:smart00317  73 NLARFINHSCEPNCELLFVEVNGD-DRIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 137-249 1.13e-23

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 96.44  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702    137 GWGLRTLEFIPKGRFVCEYAGEVLgFSEVQRRIHLQTKSDSNYIIAIREHVYN-GQVMETFVDPT--YIGNIGRFLNHSC 213
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLL-ITKEEADKRELLYYDKLELRLWGPYLFTlDEDSEYCIDARalYYGNWARFINHSC 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 3005702    214 EPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDY 249
Cdd:pfam00856  80 DPNCEVRVVYVNGG-PRIVIFALRDIKPGEELTIDY 114
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
126-282 5.74e-21

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 89.25  E-value: 5.74e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  126 FHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDsNYIIaireHVYNGQVmetfVDPTYIGNI 205
Cdd:COG2940   6 PRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPLH-TYLF----ELDDDGV----IDGALGGNP 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3005702  206 GRFLNHSCEPNLLMIPVRidsmvPKLALFAAKDIVPEEELSYDYSgrylnltvsedkerLDHGKLRKPCYCgaKSCT 282
Cdd:COG2940  77 ARFINHSCDPNCEADEED-----GRIFIVALRDIAAGEELTYDYG--------------LDYDEEEYPCRC--PNCR 132
transpos_IS630 NF033545
IS630 family transposase;
370-642 8.33e-16

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 78.45  E-value: 8.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   370 ERTVQWWFKKFCK-GDESLEDEERSGRPSEVDNDQ----LRAIIEADPLT----TTREVAEELN------VNHSTVVRHL 434
Cdd:NF033545  26 RSTVYRWLKRFNEgGLEGLLDKPRPGRPRKLLSEQqaelLALLLEEPPEGaghwTLRELAALLEeefgveYSRSTVRRLL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   435 KQIG-KVKKLDKWvPHELTENQKNRRFEVssslILRNHNEPFLDRIVTCDEKWI-LYDNRRRSaqWldqeeAPKHFPKPI 512
Cdd:NF033545 106 KRLGlSPKKPRPR-APKQDPEFVEKFKEV----LGLYRAPPDPAEVVFIDESGIqLLDTRGRG--W-----APKGQRRPR 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   513 LHPKKVmvtiwWSAAGLihYSFLNP--GETITSEKYAQEIDEMNQKLQRLqLALVNRKGPILLHDNARPHVAQPTLQKLN 590
Cdd:NF033545 174 VHVYGR-----RGTLNL--FGALDPltGKVFVLFTGRINSEDFIEFLEEL-LAAYPGKKIHLILDNASTHKSKKVREWLE 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 3005702   591 ELGY-EVLPHPPYSPDLLPTNYhVFKHLN-NFLQGKRFHNQQDAENAFQEFVES 642
Cdd:NF033545 246 EHGRiELHYLPPYSPWLNPIER-VWAVLKrRLLRNRAFRSVDELREAIDAFLNR 298
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 335-384 1.72e-14

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 67.93  E-value: 1.72e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 3005702    335 KKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGD 384
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRSGD 50
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 369-637 1.21e-07

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 54.09  E-value: 1.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  369 NERTVQWWFKKFCK-GDESLEDEERSGRPSEVDNDQLRAIIE--------ADPLTTTREVAEEL------NVNHSTVVRH 433
Cdd:COG3415  51 SRSTVYRWLKRYREgGLAGLKDRPRGGRPSKLSDEQRERLLEllrekspdQGSRWTLAELAELLeeefgvEVSPSTVRRL 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  434 LKQIGKVKKLDKWVPHEltenqKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPIL 513
Cdd:COG3415 131 LKRLGLSYKKPRPRAPK-----QDPEAVEKFKKELEALLAKPAKAEVAGVDEGDEIGALRRAAGGRLLAPGGRVRRTGAS 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  514 HPKkvmvtiwwSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELG 593
Cdd:COG3415 206 VRR--------GRALLFLALGLALGLRIGLTIDALLAGALLLFLRLLAERALALLLLLLLLLLLSPSKAVARAAKLLKLE 277

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 3005702  594 YEVLPHPPYSP-DLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQ 637
Cdd:COG3415 278 LLRLLFLPPSAsLLLALEALLRELRERNLLRLAHASLLLLFAAAR 322
HTH_32 pfam13565
Homeodomain-like domain;
372-434 1.37e-07

Homeodomain-like domain;


Pssm-ID: 463923 [Multi-domain]  Cd Length: 73  Bit Score: 49.22  E-value: 1.37e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3005702    372 TVQWWFKKFCK-GDESLEDEERSGRPSEVDNDQLRAIIEA---DPLTTTREVAEEL------NVNHSTVVRHL 434
Cdd:pfam13565   1 TVYRWRKRYNEeGLEGLEDRPRRGRPRKLTDEQEARLLALlceEPRWSPRLLAERLeeefgvKVSRSTVRRIL 73
 
Name Accession Description Interval E-value
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 38-290 3.25e-160

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 460.61  E-value: 3.25e-160
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   38 FQYTPDHVVGPGADIDPTQITFPGCICVKTPCLPGTCSCLRH-GENYDDNSCLRDIGSggKYAEPVFECNVLCRCSDHCR 116
Cdd:cd10544   3 FQYTPENVPGPGADTDPNEITFPGCDCKTSSCEPETCSCLRKyGPNYDDDGCLLDFDG--KYSGPVFECNSMCKCSESCQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  117 NRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYNGQVMETF 196
Cdd:cd10544  81 NRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYIIVLREHLSSGKVLETF 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  197 VDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHGKLRKPCYC 276
Cdd:cd10544 161 VDPTYIGNIGRFLNHSCEPNLFMVPVRVDSMVPKLALFAARDIVAGEELSFDYSGEFSNSVESVTLARQDESKSRKPCLC 240

                       250
                ....*....|....
gi 3005702  277 GAKSCTAFLPFDSS 290
Cdd:cd10544 241 GAENCRGFLPFDES 254
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 38-250 7.55e-100

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 304.68  E-value: 7.55e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   38 FQYTPDHVVGPGADIDPTQITFPGCICvKTPCLPGTCSCLRH---GENYDDNSCLRDIgsggKYAEPVFECNVLCRCSDH 114
Cdd:cd10538   3 FTYIKDNIVGKNVQPFSNIIDSVGCKC-KDDCLDSKCACAAEsdgIFAYTKNGLLRLN----NSPPPIFECNSKCSCDDD 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  115 CRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYN-GQVM 193
Cdd:cd10538  78 CKNRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSdGDGE 157

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  194 ETFVDPTYIGNIGRFLNHSCEPNLLMIPVRI---DSMVPKLALFAAKDIVPEEELSYDYS 250
Cdd:cd10538 158 ELCVDATFCGNVSRFINHSCDPNLFPFNVVIdhdDLRYPRIALFATRDILPGEELTFDYG 217
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 38-285 4.39e-55

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 188.27  E-value: 4.39e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   38 FQYTPDHVVGPGADIDPTQITfpGCICVkTPCLPGTCSC----LRHGENYDDNSCLRdIGSGGkyaePVFECNVLCRCSD 113
Cdd:cd10542   3 FQYINDYIPGDGVKIPEDFLV--GCECT-EDCHNNNPTCcpaeSGVKFAYDKQGRLR-LPPGT----PIYECNSRCKCGP 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  114 HCRNRVVQKGLQFHFQVFKTH-KKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIRehvYNGQV 192
Cdd:cd10542  75 DCPNRVVQRGRKVPLCIFRTSnGRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLD---YNDDD 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  193 METFVDPTYIGNIGRFLNHSCEPNLLMIPVRI---DSMVPKLALFAAKDIVPEEELSYDYSGrYLNLTVSEDKERLDhGK 269
Cdd:cd10542 152 CEYTVDAAYYGNISHFINHSCDPNLAVYAVWInhlDPRLPRIAFFAKRDIKAGEELTFDYLM-TGTGGSSESTIPKP-KD 229

                       250
                ....*....|....*.
gi 3005702  270 LRKPCYCGAKSCTAFL 285
Cdd:cd10542 230 VRVPCLCGSKNCRKYL 245
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 38-253 4.38e-51

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 176.76  E-value: 4.38e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   38 FQYTPDHVVGPGADIDPTQITFPGCICVKTpCLPGTCSCLRHGEN--YDDNSCLrdIGSGGKYAEPV-FECNVLCRCSDH 114
Cdd:cd10543   3 FLYVTENCETSPLNIDRNITSLQTCSCRDD-CSSDNCVCGRLSVRcwYDKEGRL--LPDFNKLDPPLiFECNRACSCWRN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  115 CRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlqtkSDSNYI--IAIREHvyngqv 192
Cdd:cd10543  80 CRNRVVQNGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADSR------EDDSYLfdLDNKDG------ 147

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3005702  193 mETF-VDPTYIGNIGRFLNHSCEPNllMIPVRI-----DSMVPKLALFAAKDIVPEEELSYDYSGRY 253
Cdd:cd10543 148 -ETYcIDARRYGNISRFINHLCEPN--LIPVRVfvehqDLRFPRIAFFASRDIKAGEELGFDYGEKF 211
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 61-249 5.14e-47

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 166.04  E-value: 5.14e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   61 GCICvKTPCLPGT--CSC-LRHGENYDDNSclrdigsGGKYAEP---VFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTH 134
Cdd:cd10545  23 GCDC-KNRCTDGAsdCACvKKNGGEIPYNF-------NGRLIRAkpaIYECGPLCKCPPSCYNRVTQKGLRYRLEVFKTA 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  135 KKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIhlqtkSDSNYIIAIREHvYNGQV---------------------- 192
Cdd:cd10545  95 ERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRS-----GNDDYLFDIDNR-QTNRGwdggqrldvgmsdgerssaede 168

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3005702  193 --METFVDPTYIGNIGRFLNHSCEPNLLMIPVRI---DSMVPKLALFAAKDIVPEEELSYDY 249
Cdd:cd10545 169 esSEFTIDAGSFGNVARFINHSCSPNLFVQCVLYdhnDLRLPRVMLFAADNIPPLQELTYDY 230
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 16-282 7.78e-43

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 156.30  E-value: 7.78e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   16 DVACGQENLPVGAWPP--GAAPAPFQYTPDHVVGPGADIDPTQITFPGCICvKTPCLPGT-CSClrHGENYDDNSCL--- 89
Cdd:cd10517   8 DISYGKEGVPIPCVNEidNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDC-TDGCRDKSkCAC--QQLTIEATAATpgg 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   90 RDIGSGG--------KYAEPVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLG 161
Cdd:cd10517  85 QINPSAGyqyrrlmeKLPTGVYECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILT 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  162 FSEVQRRihlQTKSDSNYI-----IAIREHV---YNGQVMET--FVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM---V 228
Cdd:cd10517 165 EDEANEE---GLQYGDEYFaeldyIEVVEKLkegYESDVEEHcyIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHdlrF 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 3005702  229 PKLALFAAKDIVPEEELSYDYsgrylNLTVS--EDKERLdhgklrkpCYCGAKSCT 282
Cdd:cd10517 242 PWVAFFASRYIRAGTELTWDY-----NYEVGsvPGKVLY--------CYCGSSNCR 284
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 71-285 1.43e-41

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 151.96  E-value: 1.43e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   71 PGTCSCLRHGEN----YDDNSCLRDIGSGgkyaePVFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFI 146
Cdd:cd20073  39 PGSCQCLEDSNEksfaYDEYGRVRANTGS-----IIYECNENCDCGINCPNRVVQRGRKLPLEIFKTKHKGWGLRCPRFI 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  147 PKGRFVCEYAGEVLGFSEVQRRihlQTKSDSNYIIAIRE-HVYNGQVMETF-VDPTYIGNIGRFLNHSCEPNLLMIPVRI 224
Cdd:cd20073 114 KAGTFIGVYLGEVITQSEAEIR---GKKYDNVGVTYLFDlDLFEDQVDEYYtVDAQYCGDVTRFINHSCDPNLAIYSVLR 190

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 3005702  225 D---SMVPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERLDHG----KLRKPCYCGAKSCTAFL 285
Cdd:cd20073 191 DksdSKIYDLAFFAIKDIPALEELTFDYSGRNNFDQLGFIGNRSNSKyinlKNKRPCYCGSANCRGWL 258
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 38-285 2.24e-41

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 151.20  E-value: 2.24e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   38 FQYTPDHVVGPGADIDPTQItfpGCIC---VKTP---CLPGTcscLRHGENYDDNSCLRDigsggKYAEPVFECNVLCRC 111
Cdd:cd10525   3 FVYINEYKVGEGVTLNQVAV---GCECqdcLSQPvggCCPGA---SKHRFAYNEQGQVKV-----RPGLPIYECNSRCRC 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  112 SDHCRNRVVQKGLQFHFQVFKTHK-KGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIR--EHVY 188
Cdd:cd10525  72 GPDCPNRVVQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDyvEDVY 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  189 NgqvmetfVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM---VPKLALFAAKDIVPEEELSYDYSGRYLNLTVSEDKERL 265
Cdd:cd10525 152 T-------VDAAYYGNISHFVNHSCDPNLQVYNVFIDNLderLPRIALFATRTIRAGEELTFDYNMQVDPVDAESTKMDS 224

                       250       260       270
                ....*....|....*....|....*....|
gi 3005702  266 DHG----------KLRKPCYCGAKSCTAFL 285
Cdd:cd10525 225 NFGlaglpgspkkRVRIECKCGVRSCRKYL 254
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 43-285 1.45e-39

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 146.69  E-value: 1.45e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   43 DHVVgPGADIDPTQITF-PGCICVKTP-CLPGTCSCLRHGENYDD----------------NSCLRDIGSGGKYaePVFE 104
Cdd:cd19473   7 EKSI-LGEGVELADEEFrSGCECTDDEdCMYSGCLCLQDVDPDDDrdpgkkknayhssgakKGCLRGHMLNSRL--PIYE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  105 CNVLCRCSDHCRNRVVQKGLQFHFQVFKT-HKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHlqtksdsNYIIAI 183
Cdd:cd19473  84 CHEGCACSDDCPNRVVERGRKVPLQIFRTsDGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRD-------AATIAQ 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  184 REHVY-----------------NGQVMEtfVDPTYIGNIGRFLNHSCEPNLlmipvRI--------DSMVPKLALFAAKD 238
Cdd:cd19473 157 RKDVYlfaldkfsdpdsldprlRGDPYE--IDGEFMSGPTRFINHSCDPNL-----RIfarvgdhaDKHIHDLAFFAIKD 229

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 3005702  239 IVPEEELSYDysgrYLNLTVSEDKERLD--HGKLRKPCYCGAKSCTAFL 285
Cdd:cd19473 230 IPRGTELTFD----YVDGVTGLDDDAGDeeKEKEMTKCLCGSPKCRGYL 274
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 38-281 9.06e-39

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 143.15  E-value: 9.06e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   38 FQYTPDHVVGPGADIDPTQITFPGCICVKTpCLPGTCSC--LRHGENYDDNSCLRdigSGGKYAEP--VFECNVLCRCSD 113
Cdd:cd10535   3 YKYVSQNCVTSPMNIDRNITHLQYCVCIDD-CSSSNCMCgqLSMRCWYDKDGRLL---PEFNMAEPplIFECNHACSCWR 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  114 HCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlqtkSDSNYIIAIREHvyNGQVM 193
Cdd:cd10535  79 NCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVR------EEDSYLFDLDNK--DGEVY 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  194 etFVDPTYIGNIGRFLNHSCEPNLlmIPVRI-----DSMVPKLALFAAKDIVPEEELSYDYSGRYLNLTvsedkerldhG 268
Cdd:cd10535 151 --CIDARFYGNVSRFINHHCEPNL--VPVRVfmahqDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIK----------G 216

                       250
                ....*....|...
gi 3005702  269 KLRKpCYCGAKSC 281
Cdd:cd10535 217 KLFS-CRCGSPKC 228
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 38-285 1.49e-38

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 142.72  E-value: 1.49e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   38 FQYTPDHVVGPGADIDpTQITFpGCICvkTPCLPGTCSCLRHGEN--YDDNSCLRdIGSGgkyaEPVFECNVLCRCSDHC 115
Cdd:cd10532   3 FYYINEYKPAPGINLD-NEATV-GCDC--SDCFFGKCCPAEAGVLfaYNEHGQLK-IPPG----TPIYECNSRCKCGPDC 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  116 RNRVVQKGLQFHFQVFKTHK-KGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIrehvyNGQVME 194
Cdd:cd10532  74 PNRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYLFDL-----DYESDE 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  195 TFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM---VPKLALFAAKDIVPEEELSYDYSGR-YLNLTVSEDKERLDHGKL 270
Cdd:cd10532 149 FTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLdtrLPRIALFSTRTIKAGEELTFDYQMKgSGDLSSDSIDNSPAKKRV 228

                       250
                ....*....|....*
gi 3005702  271 RKPCYCGAKSCTAFL 285
Cdd:cd10532 229 RTVCKCGAVTCRGYL 243
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 100-281 6.22e-36

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 135.53  E-value: 6.22e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  100 EP--VFECNVLCRCSDHCRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRihlqtkSDS 177
Cdd:cd10533  63 EPplIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAEADVR------EDD 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  178 NYIIAIREHvyNGQVMetFVDPTYIGNIGRFLNHSCEPNLlmIPVRI-----DSMVPKLALFAAKDIVPEEELSYDYSGR 252
Cdd:cd10533 137 SYLFDLDNK--DGEVY--CIDARYYGNISRFINHLCDPNI--IPVRVfmlhqDLRFPRIAFFSSRDIRTGEELGFDYGDR 210

                       170       180
                ....*....|....*....|....*....
gi 3005702  253 YLNLTVSedkerldhgklRKPCYCGAKSC 281
Cdd:cd10533 211 FWDIKSK-----------YFTCQCGSEKC 228
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 73-281 2.85e-35

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 134.57  E-value: 2.85e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   73 TCSCLR--HGENYDDNSCLRDIGSGGKYA---EPV----FECNVLCRCSDH-CRNRVVQKGLQFHFQVFKTHKKGWGLRT 142
Cdd:cd10523  45 KCACLQltARAFSKSESSPSKGGRGYKYKrlqEPIpsglYECNVSCKCNRMlCQNRVVQHGLQVRLQVFKTEKKGWGVRC 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  143 LEFIPKGRFVCEYAGEVLgfsevqRRIHLQTKSDSNYIIAIREHVYNGQVMET-------------FVDPTYIGNIGRFL 209
Cdd:cd10523 125 LDDIDKGTFVCIYAGRVL------SRARSPTEPLPPKLELPSENEVEVVTSWLilskkrklrenvcFLDASKEGNVGRFL 198

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3005702  210 NHSCEPNLLMIPVRIDSM---VPKLALFAAKDIVPEEELSYDYSgrYLNLTVSEdKErldhgklrKPCYCGAKSC 281
Cdd:cd10523 199 NHSCCPNLFVQNVFVDTHdknFPWVAFFTNRVVKAGTELTWDYS--YDAGTSPE-QE--------IPCLCGVNKC 262
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 102-282 2.18e-33

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 128.05  E-value: 2.18e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  102 VFECNVLCRCSDH-CRNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGfsevqrrihlQTKSDSNYI 180
Cdd:cd10541  67 VYECNKLCKCDPNmCQNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILT----------DDFADKEGL 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  181 IAIREHVYNGQVMET---FVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSM---VPKLALFAAKDIVPEEELSYDYSgrYL 254
Cdd:cd10541 137 EMGDEYFANLDHIEEscyIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHdlrFPWVAFFASKRIKAGTELTWDYN--YE 214

                       170       180
                ....*....|....*....|....*...
gi 3005702  255 NLTVsEDKERLdhgklrkpCYCGAKSCT 282
Cdd:cd10541 215 VGSV-EGKELL--------CCCGSNECR 233
Transposase_1 pfam01359
Transposase (partial DDE domain); This family includes the mariner transposase.
 488-567 7.28e-33

Transposase (partial DDE domain); This family includes the mariner transposase.


Pssm-ID: 460174  Cd Length: 80  Bit Score: 121.26  E-value: 7.28e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702    488 LYDNRRRSAQWLDQEEAPKHFPKPILHPKKVMVTIWWSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNR 567
Cdd:pfam01359   1 LYENKRRSAQWVDAGEPPKKVPKPELHAKKVMLSVWWDAKGVLYVELLPPGKTINAEYYASQLRKLRQALKEKRPGKVRV 80
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 126-255 1.24e-32

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 122.06  E-value: 1.24e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702     126 FHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHL--QTKSDSNYIIAIREHVYngqvmetfVDPTYIG 203
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAydTDGAKAFYLFDIDSDLC--------IDARRKG 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 3005702     204 NIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYSGRYLN 255
Cdd:smart00317  73 NLARFINHSCEPNCELLFVEVNGD-DRIVIFALRDIKPGEELTIDYGSDYAN 123
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 130-282 1.48e-30

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 116.59  E-value: 1.48e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  130 VFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSN--YIIAIREHVyngqvmetFVDPTYIGNIGR 207
Cdd:cd10531   4 LFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKSnfYILSLSDDV--------VIDATRKGNLSR 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3005702  208 FLNHSCEPNLLMIPVRIDSmVPKLALFAAKDIVPEEELSYDY-SGRYLNLTVsedkerldhgklrkPCYCGAKSCT 282
Cdd:cd10531  76 FINHSCEPNCETQKWIVNG-EYRIGIFALRDIPAGEELTFDYnFVNYNEAKQ--------------VCLCGAQNCR 136
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 127-285 9.89e-30

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 114.31  E-value: 9.89e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  127 HFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAireHVYNGQVmetfVDPTYIGNIG 206
Cdd:cd19174   1 GLERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMIEQYHNHSHHYCL---NLDSGMV----IDGYRMGNEA 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3005702  207 RFLNHSCEPNLLMIPVRIDSmVPKLALFAAKDIVPEEELSYDYsgRYLNLTVSEdkerldhgklRKPCYCGAKSCTAFL 285
Cdd:cd19174  74 RFVNHSCDPNCEMQKWSVNG-VYRIGLFALKDIPAGEELTYDY--NFHSFNVEK----------QQPCKCGSPNCRGVI 139
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 130-285 2.28e-29

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 113.44  E-value: 2.28e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  130 VFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLqtksdsnYIIAIREHVYngqVM----ETFVDPTYIGNI 205
Cdd:cd19172   6 VFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKE-------YAREGNRHYY---FMalksDEIIDATKKGNL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  206 GRFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDIVPEEELSYDYS-GRYlnltvsedkerldhGKLRKPCYCGAKSCTAF 284
Cdd:cd19172  76 SRFINHSCEPNCETQKWTVNGEL-RVGFFAKRDIPAGEELTFDYQfERY--------------GKEAQKCYCGSPNCRGY 140


                .
gi 3005702  285 L 285
Cdd:cd19172 141 I 141
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 129-285 6.89e-26

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 103.55  E-value: 6.89e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  129 QVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRI-HLQTKSDSN-YIIAIREHVYngqvmetfVDPTYIGNIG 206
Cdd:cd19173   5 EPFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLkKAHENNITNfYMLTLDKDRI--------IDAGPKGNLS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  207 RFLNHSCEPNL--LMIPVRIDsmvPKLALFAAKDIVPEEELSYDYsgrylNLTvsedkerlDHGKLRKPCYCGAKSCTAF 284
Cdd:cd19173  77 RFMNHSCQPNCetQKWTVNGD---TRVGLFAVRDIPAGEELTFNY-----NLD--------CLGNEKKVCRCGAPNCSGF 140


                .
gi 3005702  285 L 285
Cdd:cd19173 141 L 141
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 113-281 8.18e-26

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 103.45  E-value: 8.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  113 DHCRNRVVQKgLQFHfqvfKTHKKGWGLRTLEFIPKGRFVCEYAGEVLG--FSEVQRRIHLQTKSDSNYIIAIREHVYng 190
Cdd:cd10518   6 RQLRSRLKER-LRVG----KSGIHGWGLFAKRPIAAGEMVIEYVGEVIRpiVADKREKRYDEEGGGGTYMFRIDEDLV-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  191 qvmetfVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSmVPKLALFAAKDIVPEEELSYDYSgryLNltvSEDKERLdhgkl 270
Cdd:cd10518  79 ------IDATKKGNIARFINHSCDPNCYAKIITVDG-EKHIVIFAKRDIAPGEELTYDYK---FP---IEDEEKI----- 140

                       170
                ....*....|.
gi 3005702  271 rkPCYCGAKSC 281
Cdd:cd10518 141 --PCLCGAPNC 149
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 137-249 1.13e-23

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 96.44  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702    137 GWGLRTLEFIPKGRFVCEYAGEVLgFSEVQRRIHLQTKSDSNYIIAIREHVYN-GQVMETFVDPT--YIGNIGRFLNHSC 213
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLL-ITKEEADKRELLYYDKLELRLWGPYLFTlDEDSEYCIDARalYYGNWARFINHSC 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 3005702    214 EPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDY 249
Cdd:pfam00856  80 DPNCEVRVVYVNGG-PRIVIFALRDIKPGEELTIDY 114
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 129-285 3.74e-23

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 95.56  E-value: 3.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  129 QVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRI-HLQTKSDSNYiiairehvYNGQVMETFV-DPTYIGNIG 206
Cdd:cd19175   3 KLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERLwDMKHKGEKNF--------YMCEIDKDMViDATFKGNLS 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3005702  207 RFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDIVPEEELSYDYsgRYLNLTVSEDkerldhgklrkpCYCGAKSCTAFL 285
Cdd:cd19175  75 RFINHSCDPNCELQKWQVDGET-RIGVFAIRDIKKGEELTYDY--QFVQFGADQD------------CHCGSKNCRGKL 138
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
126-282 5.74e-21

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 89.25  E-value: 5.74e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  126 FHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDsNYIIaireHVYNGQVmetfVDPTYIGNI 205
Cdd:COG2940   6 PRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPHKEPLH-TYLF----ELDDDGV----IDGALGGNP 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 3005702  206 GRFLNHSCEPNLLMIPVRidsmvPKLALFAAKDIVPEEELSYDYSgrylnltvsedkerLDHGKLRKPCYCgaKSCT 282
Cdd:COG2940  77 ARFINHSCDPNCEADEED-----GRIFIVALRDIAAGEELTYDYG--------------LDYDEEEYPCRC--PNCR 132
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 129-285 2.24e-19

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 84.98  E-value: 2.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  129 QVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRI-HLQTKSDSN-YIIAIREhvyngqvmETFVDPTYIGNIG 206
Cdd:cd19212   5 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIkRAHENSVTNfYMLTVTK--------DRIIDAGPKGNYS 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3005702  207 RFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDIVPEEELSYDYSGRYLnltvsedkerldhGKLRKPCYCGAKSCTAFL 285
Cdd:cd19212  77 RFMNHSCNPNCETQKWTVNGDV-RVGLFALCDIPAGMELTFNYNLDCL-------------GNGRTECHCGADNCSGFL 141
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 116-285 2.68e-19

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 85.14  E-value: 2.68e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  116 RNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLgfsevqrRIHLQTKsdsnyiiaiREHVYNGQVM-- 193
Cdd:cd19170   4 RFRHLRKTAKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGEVI-------RSVLTDK---------REKYYESKGIgc 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  194 -------ETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSmVPKLALFAAKDIVPEEELSYDYsgrylnltvsedKERLD 266
Cdd:cd19170  68 ymfriddDEVVDATMHGNAARFINHSCEPNCYSRVVNIDG-KKHIVIFALRRILRGEELTYDY------------KFPIE 134

                       170
                ....*....|....*....
gi 3005702  267 HGKLrkPCYCGAKSCTAFL 285
Cdd:cd19170 135 DVKI--PCTCGSKKCRKYL 151
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 14-110 2.73e-19

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 83.23  E-value: 2.73e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702      14 QLDVACGQENLP---VGAWPPGAAPAPFQYTPDHVVGPGADIDPTQITFPGCICVKtPCLPGT-CSCLRHGENYDDNScl 89
Cdd:smart00468   1 CLDISNGKENVPvplVNEVDEDPPPPDFEYISEYIYGQGVPIDRSPSPLVGCSCSG-DCSSSNkCECARKNGGEFAYE-- 77

                           90       100
                   ....*....|....*....|.
gi 3005702      90 RDIGSGGKYAEPVFECNVLCR 110
Cdd:smart00468  78 LNGGLRLKRKPLIYECNSRCS 98
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 125-281 5.98e-19

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 84.01  E-value: 5.98e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  125 QFHFQVFKTHKkgWGLRTLEFIPKGRFVCEYAGEVL--GFSEVQRRIHLQTKSDSNYIIAIREhvyngqvmETFVDPTYI 202
Cdd:cd20072  14 QLKFARSAIHN--WGLYAMENISAKDMVIEYVGEVIrqQVADEREKRYLRQGIGSSYLFRIDD--------DTVVDATKK 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3005702  203 GNIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYSgrylnltVSEDKERLdhgklrkPCYCGAKSC 281
Cdd:cd20072  84 GNIARFINHCCDPNCTAKIIKVEGE-KRIVIYAKRDIAAGEELTYDYK-------FPREEDKI-------PCLCGAPNC 147
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 127-285 1.33e-18

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 82.67  E-value: 1.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  127 HFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRI-HLQTKSDSNYIIAIREHvyngqvmETFVDPTYIGNI 205
Cdd:cd19210   3 EVEIFRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIrYAQEHDITNFYMLTLDK-------DRIIDAGPKGNY 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  206 GRFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDIVPEEELSYDYsgrylNLtvsedkERLDHGKlrKPCYCGAKSCTAFL 285
Cdd:cd19210  76 ARFMNHCCQPNCETQKWTVNGDT-RVGLFALCDIKAGTELTFNY-----NL------ECLGNGK--TVCKCGAPNCSGFL 141
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 129-285 1.56e-18

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 82.73  E-value: 1.56e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  129 QVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSN--YIIAIREhvyngqvmETFVDPTYIGNIG 206
Cdd:cd19211   5 KIIKTEGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDIThfYMLTIDK--------DRIIDAGPKGNYS 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3005702  207 RFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDIVPEEELSYDYSGRYLnltvsedkerldhGKLRKPCYCGAKSCTAFL 285
Cdd:cd19211  77 RFMNHSCQPNCETQKWTVNGDT-RVGLFAVCDIPAGTELTFNYNLDCL-------------GNEKTVCRCGAPNCSGFL 141
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 118-252 5.06e-18

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 81.08  E-value: 5.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  118 RVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRR--IHLQTKSDSNYIIAIRehvYNGQVMet 195
Cdd:cd10528   9 ELILSGKEEGLKVIEIDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKReaLYAKDPSTGCYMYYFQ---YKGKTY-- 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 3005702  196 FVDPTYI-GNIGRFLNHSC-EPNLLMIPVRIDSmVPKLALFAAKDIVPEEELSYDYSGR 252
Cdd:cd10528  84 CVDATKEsGRLGRLINHSKkKPNLKTKLLVIDG-VPHLILVAKRDIKPGEELLYDYGDR 141
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 125-281 1.00e-17

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 80.46  E-value: 1.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  125 QFHFQVFKTHkkGWGLRTLEFIPKGRFVCEYAGEVL--GFSEVQRRIHLQTKSDSNYIIAIREhvyngqvmETFVDPTYI 202
Cdd:cd19169  14 QLKFAKSRIH--DWGLFALEPIAADEMVIEYVGQVIrqSVADEREKRYEAIGIGSSYLFRVDD--------DTIIDATKC 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3005702  203 GNIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYsgrylNLTVSEDKerldhgklrKPCYCGAKSC 281
Cdd:cd19169  84 GNLARFINHSCNPNCYAKIITVESQ-KKIVIYSKRPIAVNEEITYDY-----KFPIEDEK---------IPCLCGAPQC 147
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 137-250 5.23e-17

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 77.28  E-value: 5.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  137 GWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREhvyngqvmETFVDPTYIGNIGRFLNHSCEPN 216
Cdd:cd10519  12 GWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSSYLFNLND--------QFVVDATRKGNKIRFANHSSNPN 83

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 3005702  217 LLmipVRIdSMVP---KLALFAAKDIVPEEELSYDYS 250
Cdd:cd10519  84 CY---AKV-MMVNgdhRIGIFAKRDIEAGEELFFDYG 116
transpos_IS630 NF033545
IS630 family transposase;
370-642 8.33e-16

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 78.45  E-value: 8.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   370 ERTVQWWFKKFCK-GDESLEDEERSGRPSEVDNDQ----LRAIIEADPLT----TTREVAEELN------VNHSTVVRHL 434
Cdd:NF033545  26 RSTVYRWLKRFNEgGLEGLLDKPRPGRPRKLLSEQqaelLALLLEEPPEGaghwTLRELAALLEeefgveYSRSTVRRLL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   435 KQIG-KVKKLDKWvPHELTENQKNRRFEVssslILRNHNEPFLDRIVTCDEKWI-LYDNRRRSaqWldqeeAPKHFPKPI 512
Cdd:NF033545 106 KRLGlSPKKPRPR-APKQDPEFVEKFKEV----LGLYRAPPDPAEVVFIDESGIqLLDTRGRG--W-----APKGQRRPR 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702   513 LHPKKVmvtiwWSAAGLihYSFLNP--GETITSEKYAQEIDEMNQKLQRLqLALVNRKGPILLHDNARPHVAQPTLQKLN 590
Cdd:NF033545 174 VHVYGR-----RGTLNL--FGALDPltGKVFVLFTGRINSEDFIEFLEEL-LAAYPGKKIHLILDNASTHKSKKVREWLE 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 3005702   591 ELGY-EVLPHPPYSPDLLPTNYhVFKHLN-NFLQGKRFHNQQDAENAFQEFVES 642
Cdd:NF033545 246 EHGRiELHYLPPYSPWLNPIER-VWAVLKrRLLRNRAFRSVDELREAIDAFLNR 298
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 124-249 2.03e-15

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 73.08  E-value: 2.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  124 LQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDsNYIIairehVYNGQVMETF-VDPTYI 202
Cdd:cd10529   3 LTSRTVEKVVGKNRKGLVATEDISPGEPILEYKGEVSLRSEFKEDNGFFKRPS-PFVF-----FYDGFEGLPLcVDARKY 76

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 3005702  203 GNIGRFLNHSCEPNllmipVRIDSMV-----PKLALFAAKDIVPEEE--LSYDY 249
Cdd:cd10529  77 GNEARFIRRSCRPN-----AELRHVVvsngeLRLFIFALKDIRKGTEitIPFDY 125
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 116-285 1.03e-14

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 71.98  E-value: 1.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  116 RNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRR-IHLQTKSDSNYIIAIREHvyngqvme 194
Cdd:cd19206   4 RFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDKReKYYDSKGIGCYMFRIDDS-------- 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  195 TFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYsgrylNLTVSEDKERLdhgklrkPC 274
Cdd:cd19206  76 EVVDATMHGNAARFINHSCEPNCYSRVINIDGQ-KHIVIFAMRKIYRGEELTYDY-----KFPIEDASNKL-------PC 142

                       170
                ....*....|.
gi 3005702  275 YCGAKSCTAFL 285
Cdd:cd19206 143 NCGAKKCRKFL 153
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 134-255 1.12e-14

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 70.83  E-value: 1.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  134 HKKGWGLRTLEFIPKGRFVCEYAGEVLgfSEVQRRIHLQTKSDSNYIIAI-REHVYngqvmetfVDPTYIGNIGRFLNHS 212
Cdd:cd10522  11 SHNGLGLFAAETIAKGEFVGEYTGEVL--DRWEEDRDSVYHYDPLYPFDLnGDILV--------IDAGKKGNLTRFINHS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 3005702  213 CEPNLLMIpVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLN 255
Cdd:cd10522  81 DQPNLELI-VRTLKGEQHIGFVAIRDIKPGEELFISYGPKYWK 122
HTH_48 pfam17906
HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase ...
 335-384 1.72e-14

HTH domain in Mos1 transposase; The N-terminal domain of the Mos1 Mariner transposase comprises two HTH domains. This HTH domain binds in the DNA major groove to the transposons inverted repeats.


Pssm-ID: 465558 [Multi-domain]  Cd Length: 50  Bit Score: 67.93  E-value: 1.72e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 3005702    335 KKQIRAIFLFEFKMGRKAAETTRNINNAFGPGTANERTVQWWFKKFCKGD 384
Cdd:pfam17906   1 KIHLRHCILYEFLQGKSAAEAYRNICEVYGEDAVSERTFQRWFARFRSGD 50
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 136-281 4.82e-14

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 70.15  E-value: 4.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  136 KGWGLRTLEFIPKGRFVCEYAGEVLGfSEVQRRihlqtksdsnyiiaiREHVYNGQ----VM-----ETFVDPTYIGNIG 206
Cdd:cd19171  24 QGLGLYAARDIEKHTMVIEYIGEIIR-NEVANR---------------REKIYESQnrgiYMfridnDWVIDATMTGGPA 87

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 3005702  207 RFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYSGRYlnltvsEDkerlDHGKLrkPCYCGAKSC 281
Cdd:cd19171  88 RYINHSCNPNCVAEVVTFDKE-KKIIIISNRRIAKGEELTYDYKFDF------ED----DQHKI--PCLCGAPNC 149
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 17-118 1.61e-13

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 66.67  E-value: 1.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702     17 VACGQENLPVG---AWPPGAAPAPFQYTPDHVVGPGadidPTQITFPGCICvkTPCLPGTCSCLR-----HGENYDDNSC 88
Cdd:pfam05033   1 ISKGKENVPIPvvnEVDDEPPPPDFTYITSYIYPKE----FLLIIPQGCDC--GDCSSEKCSCAQlnggeFRFPYDKDGL 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 3005702     89 LRDigsggKYAEPVFECNVLCRCSDHCRNR 118
Cdd:pfam05033  75 LVP-----ESKPPIYECNPLCGCPPSCPNR 99
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 132-285 6.22e-13

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 66.97  E-value: 6.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  132 KTHKKGWGLRTLEFIPKGRFVCEYAGEVLG--FSEVQRRIHLQTKSDSNYIIAIREhvyngqvmETFVDPTYIGNIGRFL 209
Cdd:cd19204  20 RSRIHEWGLFAMEPIAADEMVIEYVGQNIRqvVADMREKRYVQEGIGSSYLFRVDH--------DTIIDATKCGNLARFI 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3005702  210 NHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYsgrylnltvsedKERLDHGKLrkPCYCGAKSCTAFL 285
Cdd:cd19204  92 NHCCTPNCYAKVITIESQ-KKIVIYSKQPIGVNEEITYDY------------KFPIEDNKI--PCLCGTENCRGTL 152
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 129-249 7.03e-12

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 64.35  E-value: 7.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  129 QVFKTHKKGW-GLRTLEFIPKGRFVCEYAGEVLGFSEvqrrihLQTKSDSNY--IIAIREHVYngqvmetFVD--PTYI- 202
Cdd:cd19183   4 SSIGLANASRfGLFADRPIPAGDPIQELLGEIGLQSE------YIADPENQYqiLGAPKPHVF-------FHPqsPLYId 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 3005702  203 ----GNIGRFLNHSCEPNLLMIPVRIDS-MVPKLALFAAKDIVPEEELSYDY 249
Cdd:cd19183  71 trrsGSVARFIRRSCRPNAELVTVASDSgSVLKFVLYASRDISPGEEITIGW 122
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 127-249 1.37e-11

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 60.34  E-value: 1.37e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  127 HFQVFKTHKKGWGLRTLEFIPKGRFVCeyagevlgfsevqrrihlqtksdsnyiiairehvyngqvmetfvdptyignIG 206
Cdd:cd08161   1 EIRPSTIPGAGFGLFATRDIPKGEVIG---------------------------------------------------LA 29

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 3005702  207 RFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDY 249
Cdd:cd08161  30 RFINHSCEPNCEFEEVYVGGK-PRVFIVALRDIKAGEELTVDY 71
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 137-253 1.44e-11

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 62.21  E-value: 1.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  137 GWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVYngqvmetfVDPTYIGNIGRFLNHS---- 212
Cdd:cd19168  13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVSYLYLFEEQEGIW--------VDAAIYGNLSRYINHAtdkv 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 3005702  213 ----CEPNLLMIPVRIdsmvpKLALFAAKDIVPEEELSYDYSGRY 253
Cdd:cd19168  85 ktgnCMPKIMYVNHEW-----RIKFTAIKDIKIGEELFFNYGDNF 124
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 116-285 1.80e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 62.73  E-value: 1.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  116 RNRVVQKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLgfsevqrRIHLQTKsdsnyiiaiREHVYNGQ---- 191
Cdd:cd19207   4 RFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVI-------RSVLTDK---------REKFYDSKgigc 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  192 ---VMETF--VDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYsgrylnltvsedKERLD 266
Cdd:cd19207  68 ymfRIDDFdvVDATMHGNAARFINHSCEPNCYSRVIHVEGQ-KHIVIFALRKIYRGEELTYDY------------KFPIE 134

                       170
                ....*....|....*....
gi 3005702  267 HGKLRKPCYCGAKSCTAFL 285
Cdd:cd19207 135 DASNKLPCNCGAKRCRRFL 153
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 121-249 3.31e-11

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 61.24  E-value: 3.31e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  121 QKGLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREhvyngqvmETFVDPT 200
Cdd:cd19217   1 QRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNN--------DFVVDAT 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 3005702  201 YIGNIGRFLNHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDY 249
Cdd:cd19217  73 RKGNKIRFANHSVNPNCYAKVVMVNGD-HRIGIFAKRAIQQGEELFFDY 120
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 132-285 4.64e-11

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 61.61  E-value: 4.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  132 KTHKKGWGLRTLEFIPKGRFVCEYAGEVLG--FSEVQRRIHLQTKSDSNYIIAIrEHvyngqvmETFVDPTYIGNIGRFL 209
Cdd:cd19205  20 KSHIHDWGLFAMEPIAADEMVIEYVGQNIRqvIADMREKRYEDEGIGSSYMFRV-DH-------DTIIDATKCGNFARFI 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3005702  210 NHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYsgrylNLTVSEDKerldhgklrKPCYCGAKSCTAFL 285
Cdd:cd19205  92 NHSCNPNCYAKVITVESQ-KKIVIYSKQHINVNEEITYDY-----KFPIEDVK---------IPCLCGSENCRGTL 152
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 123-250 1.01e-09

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 56.84  E-value: 1.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  123 GLQFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKsdsnYIIAIREHVYNGQVmetfVDPTYI 202
Cdd:cd19218   1 GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK----YMCSFLFNLNNDFV----VDATRK 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 3005702  203 GNIGRFLNHSCEPNLLMiPVRIDSMVPKLALFAAKDIVPEEELSYDYS 250
Cdd:cd19218  73 GNKIRFANHSVNPNCYA-KVMMVNGDHRIGIFAKRAIQTGEELFFDYR 119
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 132-285 2.33e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 53.55  E-value: 2.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  132 KTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSN-YIIAIR-EHVyngqvmetfVDPTYIGNIGRFL 209
Cdd:cd19209  22 RSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGiYMFRINnEHV---------IDATLTGGPARYI 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3005702  210 NHSCEPNLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYsgrylNLTVSEDKERLdhgklrkPCYCGAKSCTAFL 285
Cdd:cd19209  93 NHSCAPNCVAEVVTFDKE-DKIIIISSRRIPKGEELTYDY-----QFDFEDDQHKI-------PCHCGAWNCRKWM 155
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 369-637 1.21e-07

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 54.09  E-value: 1.21e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  369 NERTVQWWFKKFCK-GDESLEDEERSGRPSEVDNDQLRAIIE--------ADPLTTTREVAEEL------NVNHSTVVRH 433
Cdd:COG3415  51 SRSTVYRWLKRYREgGLAGLKDRPRGGRPSKLSDEQRERLLEllrekspdQGSRWTLAELAELLeeefgvEVSPSTVRRL 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  434 LKQIGKVKKLDKWVPHEltenqKNRRFEVSSSLILRNHNEPFLDRIVTCDEKWILYDNRRRSAQWLDQEEAPKHFPKPIL 513
Cdd:COG3415 131 LKRLGLSYKKPRPRAPK-----QDPEAVEKFKKELEALLAKPAKAEVAGVDEGDEIGALRRAAGGRLLAPGGRVRRTGAS 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  514 HPKkvmvtiwwSAAGLIHYSFLNPGETITSEKYAQEIDEMNQKLQRLQLALVNRKGPILLHDNARPHVAQPTLQKLNELG 593
Cdd:COG3415 206 VRR--------GRALLFLALGLALGLRIGLTIDALLAGALLLFLRLLAERALALLLLLLLLLLLSPSKAVARAAKLLKLE 277

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 3005702  594 YEVLPHPPYSP-DLLPTNYHVFKHLNNFLQGKRFHNQQDAENAFQ 637
Cdd:COG3415 278 LLRLLFLPPSAsLLLALEALLRELRERNLLRLAHASLLLLFAAAR 322
HTH_32 pfam13565
Homeodomain-like domain;
372-434 1.37e-07

Homeodomain-like domain;


Pssm-ID: 463923 [Multi-domain]  Cd Length: 73  Bit Score: 49.22  E-value: 1.37e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3005702    372 TVQWWFKKFCK-GDESLEDEERSGRPSEVDNDQLRAIIEA---DPLTTTREVAEEL------NVNHSTVVRHL 434
Cdd:pfam13565   1 TVYRWRKRYNEeGLEGLEDRPRRGRPRKLTDEQEARLLALlceEPRWSPRLLAERLeeefgvKVSRSTVRRIL 73
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 136-285 1.88e-07

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 51.17  E-value: 1.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  136 KGWGLRTLEFIPKGRFVCEYAGEVLGfSEVQRRIHLQTKSDSNYIIAIRehVYNGQVmetfVDPTYIGNIGRFLNHSCEP 215
Cdd:cd19208  25 QGLGLYAARDIEKHTMVIEYIGTIIR-NEVANRKEKLYESQNRGVYMFR--IDNDHV----IDATLTGGPARYINHSCAP 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  216 NLLMIPVRIDSMvPKLALFAAKDIVPEEELSYDYsgrylNLTVSEDKERLdhgklrkPCYCGAKSCTAFL 285
Cdd:cd19208  98 NCVAEVVTFEKG-HKIIISSSRRIQKGEELCYDY-----KFDFEDDQHKI-------PCHCGAVNCRKWM 154
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 145-251 6.72e-06

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 46.25  E-value: 6.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  145 FIPKGRFVCEYAGEVLGFSEvqrRIHLQTKSdsnyiiaIREHVYNGQVMETFVD-PTYIGNIGRFL----NHSCE----P 215
Cdd:cd10539  23 FIKDLTIIAEYTGDVDYIRN---REFDDNDS-------IMTLLLAGDPSKSLVIcPDKRGNIARFIsginNHTKDgkkkQ 92

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 3005702  216 NLLMIPVRIDSMVPKLaLFAAKDIVPEEELSYDYSG 251
Cdd:cd10539  93 NCKCVRYSINGEARVL-LVATRDIAKGERLYYDYNG 127
COG3335 COG3335
Transposase [Mobilome: prophages, transposons];
575-642 1.61e-05

Transposase [Mobilome: prophages, transposons];


Pssm-ID: 442564 [Multi-domain]  Cd Length: 292  Bit Score: 47.17  E-value: 1.61e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3005702  575 DNARPHVAQPTLQKLNELGYEVLPHPPYSPDLLPTNyHVFKHLNNFL-QGKRFHNQQDAENAFQEFVES 642
Cdd:COG3335 206 DNASFHKSKAVREWLEEAGIELLFLPPYSPDLNPIE-RLWSKLKALLrKNRAFRSKDELKAAVRSFLDR 273
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 208-257 4.48e-04

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 40.44  E-value: 4.48e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 3005702  208 FLNHSCEPNLlmipVRIDSMVPKLALFAAKDIVPEEELSYDYSGRYLNLT 257
Cdd:cd20071  58 LLNHSCDPNA----VVVFDGNGTLRVRALRDIKAGEELTISYIDPLLPRT 103
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 135-253 1.04e-03

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 39.96  E-value: 1.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  135 KKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIREHVyngqvMETFVDPtyigniGRFLNHSCE 214
Cdd:cd10524  17 HYGAKIIATKPIKKGEKIHELCGCIAELSEEEEALLRPGGNDFSVMYSSRKKC-----SQLWLGP------AAFINHDCR 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 3005702  215 PNLLMIPVRIDSMVPKlalfAAKDIVPEEELSYDYSGRY 253
Cdd:cd10524  86 PNCKFVPTGKSTACVK----VLRDIEPGEEITVYYGDNY 120
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 123-250 1.29e-03

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 39.99  E-value: 1.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  123 GLQFHFQ---VFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSdsnYIIAIREHVYNGqvMETFVDP 199
Cdd:cd19181   1 GSQMQLQlgrVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKRP---YPFVLFYSKFNG--VEMCVDA 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3005702  200 TYIGNIGRFLNHSCEPNLLMIPVRIDSMVpKLALFAAKDIVPEEELS----YDYS 250
Cdd:cd19181  76 RTFGNDARFIRRSCTPNAEVRHMIADGMI-HLCIYAVAAIAKDAEVTiafdYEYS 129
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 127-253 5.79e-03

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 37.23  E-value: 5.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3005702  127 HFQVFKTHKKGWGLRTLEFIPKGRFVcEYAGeVLGFSEvQRRIHLQTKSDSNYIIAIREhvyNGQVMEtfvdptyIGnIG 206
Cdd:cd10540   1 RLEVKPSTLKGRGVFATRPIKKGEVI-EEAP-VIVLPK-EEYQHLCKTVLDHYVFSWGD---GCLALA-------LG-YG 66

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 3005702  207 RFLNHSCEPNLLmipVRIDSMVPKLALFAAKDIVPEEELSYDYSGRY 253
Cdd:cd10540  67 SMFNHSYTPNAE---YEIDFENQTIVFYALRDIEAGEELTINYGDDL 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH