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Conserved domains on  [gi|3283220|gb|AAC25166|]
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splicing factor hPRP17 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 244-542 6.43e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.27  E-value: 6.43e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  244 IHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGERrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 323
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  324 TETGQCISRFTN-RKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFvDENRRFVST-SD 401
Cdd:cd00200  80 LETGECVRTLTGhTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASsSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  402 DKSLRVWEwdiPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFrlnKKKIFKGHmvAGYACQVDF 479
Cdd:cd00200 156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3283220  480 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPhETSKVITCGWDGLIKLWD 542
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 244-542 6.43e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.27  E-value: 6.43e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  244 IHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGERrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 323
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  324 TETGQCISRFTN-RKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFvDENRRFVST-SD 401
Cdd:cd00200  80 LETGECVRTLTGhTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASsSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  402 DKSLRVWEwdiPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFrlnKKKIFKGHmvAGYACQVDF 479
Cdd:cd00200 156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3283220  480 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPhETSKVITCGWDGLIKLWD 542
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
242-542 5.87e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.52  E-value: 5.87e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  242 KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 321
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  322 WDTETGQCISRFTNRKVP-YCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 400
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAvRSVAFSPD---GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  401 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 478
Cdd:COG2319 266 ADGTVRLWDLA---TGELLRTLTGHSGGvnSVAFSPDGKLLASGSDDGTVRLWDLATGKLL---RTLTGH--TGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3283220  479 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 542
Cdd:COG2319 338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWD 400
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 269-451 2.36e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220   269 SCSMDCKIKLWEVygERRCLRTFIG-HSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNP 346
Cdd:PLN00181 550 SSNFEGVVQVWDV--ARSQLVTEMKeHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220   347 DEDKQNLFvaGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENrRFVSTSDDKSLRVweWDIPVDFKYIAEPSMH 425
Cdd:PLN00181 628 ESGRSLAF--GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKL--WDLSMSISGINETPLH 702

                        170       180       190
                 ....*....|....*....|....*....|...
gi 3283220   426 SMPA-------VTLSPNGKWLACQSMDNQILIF 451
Cdd:PLN00181 703 SFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 285-323 1.25e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3283220     285 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 323
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
285-323 1.77e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.77e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3283220    285 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 323
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 244-542 6.43e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.27  E-value: 6.43e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  244 IHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVYGERrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 323
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  324 TETGQCISRFTN-RKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFvDENRRFVST-SD 401
Cdd:cd00200  80 LETGECVRTLTGhTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASsSQ 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  402 DKSLRVWEwdiPVDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFrlnKKKIFKGHmvAGYACQVDF 479
Cdd:cd00200 156 DGTIKLWD---LRTGKCVATLTGHTGEvnSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGH--ENGVNSVAF 227

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3283220  480 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPhETSKVITCGWDGLIKLWD 542
Cdd:cd00200 228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
242-542 5.87e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.52  E-value: 5.87e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  242 KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 321
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  322 WDTETGQCISRFTNRKVP-YCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 400
Cdd:COG2319 189 WDLATGKLLRTLTGHTGAvRSVAFSPD---GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  401 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 478
Cdd:COG2319 266 ADGTVRLWDLA---TGELLRTLTGHSGGvnSVAFSPDGKLLASGSDDGTVRLWDLATGKLL---RTLTGH--TGAVRSVA 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3283220  479 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 542
Cdd:COG2319 338 FSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
242-542 4.92e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 4.92e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  242 KQIHVWSGHTKGVSAVRLFPLsGHLLLSCSMDCKIKLWEVYGeRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 321
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  322 WDTETGQCISRFT-NRKVPYCVKFNPDEdkqNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 400
Cdd:COG2319 147 WDLATGKLLRTLTgHSGAVTSVAFSPDG---KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  401 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 478
Cdd:COG2319 224 ADGTVRLWDLA---TGKLLRTLTGHSGSvrSVAFSPDGRLLASGSADGTVRLWDLATGELL---RTLTGH--SGGVNSVA 295

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3283220  479 FSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHEtSKVITCGWDGLIKLWD 542
Cdd:COG2319 296 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWD 358
WD40 COG2319
WD40 repeat [General function prediction only];
242-502 8.43e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 184.73  E-value: 8.43e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  242 KQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 321
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  322 WDTETGQCISRFT-NRKVPYCVKFNPDEDkqnLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 400
Cdd:COG2319 231 WDLATGKLLRTLTgHSGSVRSVAFSPDGR---LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  401 DDKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVD 478
Cdd:COG2319 308 DDGTVRLWDLA---TGKLLRTLTGHTGAvrSVAFSPDGKTLASGSDDGTVRLWDLATGELL---RTLTGH--TGAVTSVA 379

                       250       260
                ....*....|....*....|....
gi 3283220  479 FSPDMSYVISGDGNGKLNIWDWKT 502
Cdd:COG2319 380 FSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
243-542 2.38e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.22  E-value: 2.38e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  243 QIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGerRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLW 322
Cdd:COG2319  28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG--ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  323 DTETGQCISRFT-NRKVPYCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSD 401
Cdd:COG2319 106 DLATGLLLRTLTgHTGAVRSVAFSPD---GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  402 DKSLRVWEWDipvDFKYIAEPSMHSMP--AVTLSPNGKWLACQSMDNQILIFGAQNRFRLnkkKIFKGHmvAGYACQVDF 479
Cdd:COG2319 183 DGTVRLWDLA---TGKLLRTLTGHTGAvrSVAFSPDGKLLASGSADGTVRLWDLATGKLL---RTLTGH--SGSVRSVAF 254

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3283220  480 SPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 542
Cdd:COG2319 255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWD 316
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 242-409 5.10e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 5.10e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  242 KQIHVWSGHTKGVSAVRlFPLSGHLLLSCSMDCKIKLWEVYGERrCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKL 321
Cdd:cd00200 126 KCLTTLRGHTDWVNSVA-FSPDGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  322 WDTETGQCISRFTNRKVP-YCVKFNPDedkQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTS 400
Cdd:cd00200 204 WDLSTGKCLGTLRGHENGvNSVAFSPD---GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                ....*....
gi 3283220  401 DDKSLRVWE 409
Cdd:cd00200 281 ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
241-411 4.96e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 4.96e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  241 KKQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWEVyGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLK 320
Cdd:COG2319 278 GELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  321 LWDTETGQCISRFTNrkvpycvkfnpdedkqnlfvagmsdkkivqwdirsgeivqeydrHLGAVNTIVFVDENRRFVSTS 400
Cdd:COG2319 356 LWDLATGELLRTLTG--------------------------------------------HTGAVTSVAFSPDGRTLASGS 391

                       170
                ....*....|.
gi 3283220  401 DDKSLRVWEWD 411
Cdd:COG2319 392 ADGTVRLWDLA 402
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 269-451 2.36e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 2.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220   269 SCSMDCKIKLWEVygERRCLRTFIG-HSKAVRDICFNTAGTQFL-SAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNP 346
Cdd:PLN00181 550 SSNFEGVVQVWDV--ARSQLVTEMKeHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220   347 DEDKQNLFvaGMSDKKIVQWDIRSGEI-VQEYDRHLGAVNTIVFVDENrRFVSTSDDKSLRVweWDIPVDFKYIAEPSMH 425
Cdd:PLN00181 628 ESGRSLAF--GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKL--WDLSMSISGINETPLH 702

                        170       180       190
                 ....*....|....*....|....*....|...
gi 3283220   426 SMPA-------VTLSPNGKWLACQSMDNQILIF 451
Cdd:PLN00181 703 SFMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 285-323 1.25e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.25e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 3283220     285 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 323
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
285-323 1.77e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 1.77e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3283220    285 RRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWD 323
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 240-280 3.31e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 3.31e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 3283220     240 PKKQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWE 280
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
241-280 1.92e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.92e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 3283220    241 KKQIHVWSGHTKGVSAVRLFPlSGHLLLSCSMDCKIKLWE 280
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 370-409 1.36e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3283220     370 SGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 409
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 502-542 1.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 3283220     502 TTKLYSRFKAHDKVCIGAVWHPHEtSKVITCGWDGLIKLWD 542
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
371-409 2.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3283220    371 GEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 409
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 460-499 5.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 5.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 3283220     460 NKKKIFKGHmvAGYACQVDFSPDMSYVISGDGNGKLNIWD 499
Cdd:smart00320   3 ELLKTLKGH--TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 249-386 7.53e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 7.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220   249 GHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLR-------TFIGHSKAVRDICFNTAGTQFL-SAAYDRYLK 320
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGHKKKISIIDWNPMNYYIMcSSGFDSFVN 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 3283220   321 LWDTETGQCISRFTNRKVPYCVKFNPdedKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNT 386
Cdd:PTZ00420 152 IWDIENEKRAFQINMPKKLSSLKWNI---KGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNT 214
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
310-439 1.48e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3283220  310 FLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDedKQNLFVAGMSDKKIVQWDIRSGEIVQEYDrhLGA-VNTIV 388
Cdd:COG3391  83 YVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPD--GGRLYVADSGNGRVSVIDTATGKVVATIP--VGAgPHGIA 158

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 3283220  389 FVDENRR-FVSTSDDKSLRVW--EWDiPVDFKYIAEPSMHSMP-AVTLSPNGKWL 439
Cdd:COG3391 159 VDPDGKRlYVANSGSNTVSVIvsVID-TATGKVVATIPVGGGPvGVAVSPDGRRL 212
WD40 pfam00400
WD domain, G-beta repeat;
504-542 3.41e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 3.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 3283220    504 KLYSRFKAHDKVCIGAVWHPHETsKVITCGWDGLIKLWD 542
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
460-499 6.99e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 6.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 3283220    460 NKKKIFKGHmvAGYACQVDFSPDMSYVISGDGNGKLNIWD 499
Cdd:pfam00400   2 KLLKTLEGH--TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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