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Conserved domains on  [gi|4753142|gb|AAC33834|]
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chemokine CX3C [Rattus norvegicus]

Protein Classification

C-C motif chemokine( domain architecture ID 10084524)

C-C motif chemokine recruits and activates leukocytes, and plays a major role in both immune response and inflammation-related diseases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 25-100 9.45e-54

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


:

Pssm-ID: 238172  Cd Length: 76  Bit Score: 172.56  E-value: 9.45e-54
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4753142   25 QHLGMTKCNITCHKMTSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNG 100
Cdd:cd00274   1 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQESCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 76
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 111-333 1.66e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142    111 TPRITSATRGLSPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAA----VTGSSPSTSKAQDAGLAAKPQSTGI 186
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPpaapAAGPPRRLTRPAVASLSESRESLPS 2800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142    187 SEVAAVSTTIWPSSAVYQSGSSLWAeekATESPPTIALSTQASTTSSPKQNVGSEGQ--PPWVQEQDSTPEKSPGPEETN 264
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPA---GPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvAPGGDVRRRPPSRSPAAKPAA 2877

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4753142    265 PVHTDIFQDRGPG---STVHPSVAPTSSEKTPSPELVASGSQAPKVEEPIHATADPQKlsvfiTPVPDSQAA 333
Cdd:PHA03247 2878 PARPPVRRLARPAvsrSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-----PPRPQPPLA 2944
 
Name Accession Description Interval E-value
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 25-100 9.45e-54

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


Pssm-ID: 238172  Cd Length: 76  Bit Score: 172.56  E-value: 9.45e-54
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4753142   25 QHLGMTKCNITCHKMTSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNG 100
Cdd:cd00274   1 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQESCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 76
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 36-89 3.48e-18

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 77.67  E-value: 3.48e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 4753142      36 CHKMTS-PIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHL 89
Cdd:smart00199   5 CLSYTSkKIPLKRIKSYYPTSSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 30-89 5.68e-14

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 66.14  E-value: 5.68e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4753142     30 TKCnitCHKMTS-PIPVTLLIHY--QLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHL 89
Cdd:pfam00048   1 SDC---CLRYSSkPIPLKRVKSYeiQPASSSCPKPAVIFLTKKGRQVCADPKAKWVQRLIKKL 60
PHA03247 PHA03247
large tegument protein UL36; Provisional
 111-333 1.66e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142    111 TPRITSATRGLSPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAA----VTGSSPSTSKAQDAGLAAKPQSTGI 186
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPpaapAAGPPRRLTRPAVASLSESRESLPS 2800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142    187 SEVAAVSTTIWPSSAVYQSGSSLWAeekATESPPTIALSTQASTTSSPKQNVGSEGQ--PPWVQEQDSTPEKSPGPEETN 264
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPA---GPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvAPGGDVRRRPPSRSPAAKPAA 2877

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4753142    265 PVHTDIFQDRGPG---STVHPSVAPTSSEKTPSPELVASGSQAPKVEEPIHATADPQKlsvfiTPVPDSQAA 333
Cdd:PHA03247 2878 PARPPVRRLARPAvsrSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-----PPRPQPPLA 2944
 
Name Accession Description Interval E-value
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 25-100 9.45e-54

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


Pssm-ID: 238172  Cd Length: 76  Bit Score: 172.56  E-value: 9.45e-54
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4753142   25 QHLGMTKCNITCHKMTSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNG 100
Cdd:cd00274   1 QHHGVTKCNITCSKMTSKIPVALLIHYQQNQESCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG 76
SCY smart00199
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ...
 36-89 3.48e-18

Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response.


Pssm-ID: 197570  Cd Length: 59  Bit Score: 77.67  E-value: 3.48e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 4753142      36 CHKMTS-PIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHL 89
Cdd:smart00199   5 CLSYTSkKIPLKRIKSYYPTSSHCPKPAVIFTTKKGRKVCADPKAKWVQRYIKKL 59
Chemokine_CC cd00272
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 40-90 6.53e-16

Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD.


Pssm-ID: 238170  Cd Length: 57  Bit Score: 71.51  E-value: 6.53e-16
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 4753142   40 TSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLD 90
Cdd:cd00272   7 KKRIPLRVLKSYRRTSSSCSKPAVIFKTKRGREVCADPKQKWVQRYMKLLD 57
Chemokine cd00169
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 35-90 1.86e-15

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


Pssm-ID: 238098  Cd Length: 59  Bit Score: 70.06  E-value: 1.86e-15
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4753142   35 TCHKMTS-PIPVTLLIHYQLNQ--ESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLD 90
Cdd:cd00169   1 CCLKYTSkPIPPKNIKSYRVQEagGHCSIPAVIFTTKKGRKVCADPKEPWVKDLIQKLD 59
IL8 pfam00048
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ...
 30-89 5.68e-14

Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds.


Pssm-ID: 459650  Cd Length: 60  Bit Score: 66.14  E-value: 5.68e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4753142     30 TKCnitCHKMTS-PIPVTLLIHY--QLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHL 89
Cdd:pfam00048   1 SDC---CLRYSSkPIPLKRVKSYeiQPASSSCPKPAVIFLTKKGRQVCADPKAKWVQRLIKKL 60
Chemokine_CC_DCCL cd01119
Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL ...
 42-90 1.63e-10

Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic progenitor proliferation by blocking progression through the cell cycle; DCCL subgroup contains Exodus-1 (also known as CCL20, MIP-3alpha, LARC, ST38 (mouse)), Exodus-2 (also known as CCL21, SLC, 6-Ckine, TCA4, CKbeta9), and Exodus-3 (also known as CCL-19, ELC, MIP-3beta, CKbeta11). Exodus-3 was shown to inhibit the growth of human breast cancer cells in vivo in a mouse model; Exodus-1, -2, and -3 were all shown to significantly inhibit chronic myelogenous leukemia progenitor cell proliferation; Exodus-2 and -3 show potent immunotherapeutic activity toward solid tumors; chemotatic for T cells, B cells, dendritic cells, macrophage progenitor cells, and NK cells; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates. See CDs: Chemokine_CC (cd00272) for the entire CC subgroup, Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups.


Pssm-ID: 238539  Cd Length: 61  Bit Score: 56.26  E-value: 1.63e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 4753142   42 PIPVTLLI--HYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLD 90
Cdd:cd01119  11 PIPWRVLRgyTYQEISESCDIPAIIFHTRRGRKVCADPKQDWVKRAIQLLS 61
Chemokine_C cd00271
Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on ...
 40-99 3.01e-05

Chemokine_C, C or lymphotactin subgroup, 1 of 4 subgroup designations of chemokines based on the arrangement of two N-terminal, conserved cysteine residues. Most of the known chemokines (cd00169) belong to either the CC (cd00272) or CXC (cd00273) subclass. The two other subclasses each have a single known member: fractalkine for the CX3C (cd00274) class and lymphotactin for the C (cd00271) class. Chemokine_Cs differ structurally since they contain only one of the two disulfide bridges that are conserved in all other chemokines and they possess a unique C-terminal extension, which is required for biological activity and thought to play a role in receptor binding. Lymphotactin, a mediator of mucosal immunity, has been found to chemoattract neutrophils and B cells through the XCR1 receptor and thought to be a factor in acute allograft rejection and inflammatory bowel disease.


Pssm-ID: 238169  Cd Length: 72  Bit Score: 41.76  E-value: 3.01e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142   40 TSPIPVTLLIHYQLNQESCgkRAIILETRQHRHFCADPKEKWVQDAMKHLDHQtaALTRN 99
Cdd:cd00271  16 TQRLPVQKIKTYTIKEGSV--RAVIFITKRGLKICADPQAKWVKSAVKTIDRR--ASTRK 71
PHA03247 PHA03247
large tegument protein UL36; Provisional
 111-333 1.66e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142    111 TPRITSATRGLSPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAA----VTGSSPSTSKAQDAGLAAKPQSTGI 186
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPpaapAAGPPRRLTRPAVASLSESRESLPS 2800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142    187 SEVAAVSTTIWPSSAVYQSGSSLWAeekATESPPTIALSTQASTTSSPKQNVGSEGQ--PPWVQEQDSTPEKSPGPEETN 264
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPA---GPLPPPTSAQPTAPPPPPGPPPPSLPLGGsvAPGGDVRRRPPSRSPAAKPAA 2877

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4753142    265 PVHTDIFQDRGPG---STVHPSVAPTSSEKTPSPELVASGSQAPKVEEPIHATADPQKlsvfiTPVPDSQAA 333
Cdd:PHA03247 2878 PARPPVRRLARPAvsrSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP-----PPRPQPPLA 2944
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 122-310 2.56e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142   122 SPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAAVTGSSPSTSKAQDAGLAAKPQSTGISEVAAVSTTIWPSSA 201
Cdd:PRK07764 617 APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGA 696

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142   202 V-YQSGSSLWAEEKATESPPTIALSTQASTTSSPKQNVGSEGQPPwvqeqDSTPEKSPGPEETNPVHTDIFQDRGPGSTV 280
Cdd:PRK07764 697 ApAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL-----PPEPDDPPDPAGAPAQPPPPPAPAPAAAPA 771

                        170       180       190
                 ....*....|....*....|....*....|
gi 4753142   281 HPSVAPTSSEKTPSPELVASGSQAPKVEEP 310
Cdd:PRK07764 772 AAPPPSPPSEEEEMAEDDAPSMDDEDRRDA 801
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 120-317 5.29e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.81  E-value: 5.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142   120 GLSPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAAvtgsSPSTSKAQDAGLAAKPQSTGISEVAAVSTTIWPS 199
Cdd:PRK07764 594 AAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAA----PAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142   200 SA-------VYQSGSSLWAEEKATESPPTIALSTQASTTSSPKQNVGSEGQPPWVQEQDSTPEKSPGPEETNPVHTDIFQ 272
Cdd:PRK07764 670 PAkaggaapAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPP 749

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 4753142   273 DRGPGSTVHPSVAPTSSEKTPSPELVASGSQAPKV--EEPIHATADP 317
Cdd:PRK07764 750 DPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEmaEDDAPSMDDE 796
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 137-299 8.05e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 38.31  E-value: 8.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142   137 LTLEPTAISQEARRPMGTSQEPPAAVTGSSPSTSKAQDAGLAAKPQSTGISEVAAVSTTIWPSSAVYQSGSSLWAEEKAT 216
Cdd:PRK07994 357 LAFHPAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGAT 436

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142   217 ESP-PTIALSTQASTTSSPKQNVGSEGQPPWVQEQDSTPEKSPGPEETNPVhtdifqDRGPGSTVHPSVAPTSSEKTPSP 295
Cdd:PRK07994 437 KAKkSEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPV------EVKKEPVATPKALKKALEHEKTP 510


                 ....
gi 4753142   296 ELVA 299
Cdd:PRK07994 511 ELAA 514
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 218-316 8.53e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 38.25  E-value: 8.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4753142   218 SPPTIALSTQASTTSSPKQNVGSEGQPPWVQEQDSTPEKSPGPEETNPVHTDIFQDRGPGSTVHPSVAPTSSEKTPSPEL 297
Cdd:PRK14950 362 PVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEK 441

                         90
                 ....*....|....*....
gi 4753142   298 VASGSQAPKVEEPIHATAD 316
Cdd:PRK14950 442 PKYTPPAPPKEEEKALIAD 460
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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