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Conserved domains on  [gi|3639092|gb|AAC36316|]
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cystatin-related epididymal spermatogenic protein [Mus musculus]

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 38-140 7.99e-25

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 91.34  E-value: 7.99e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3639092      38 INISNANVKQCVWFAMKEYNKESEDKYVFLVDKILHAKLQITDRMEYQIDVQISRSNCKKPLNNTENCIPQKKPElekkM 117
Cdd:smart00043   9 VPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGE----K 84

                           90       100
                   ....*....|....*....|...
gi 3639092     118 SCSFLVGALPWNGEFNLLSKECK 140
Cdd:smart00043  85 FCTAKVWEKPWENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 38-140 7.99e-25

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 91.34  E-value: 7.99e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3639092      38 INISNANVKQCVWFAMKEYNKESEDKYVFLVDKILHAKLQITDRMEYQIDVQISRSNCKKPLNNTENCIPQKKPElekkM 117
Cdd:smart00043   9 VPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGE----K 84

                           90       100
                   ....*....|....*....|...
gi 3639092     118 SCSFLVGALPWNGEFNLLSKECK 140
Cdd:smart00043  85 FCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 38-139 2.39e-22

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 84.83  E-value: 2.39e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3639092   38 INISNANVKQCVWFAMKEYNKESEDKYvFLVDKILHAKLQITDRMEYQIDVQISRSNCKKPLNNtENCIPQKKPELEKKM 117
Cdd:cd00042   6 IPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVP-LDCPDCKLLEEGKKK 83

                        90       100
                ....*....|....*....|..
gi 3639092  118 SCSFLVGALPWNGEFNLLSKEC 139
Cdd:cd00042  84 FCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 36-128 1.36e-20

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 80.07  E-value: 1.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3639092     36 GSINISNA--NVKQCVWFAMKEYNKESeDKYVFLVDKILHAKLQITDRMEYQIDVQISRSNCKKPLNNTENCIPQKKPEL 113
Cdd:pfam00031   2 GLSPIPDNspELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|....*
gi 3639092    114 EkkmSCSFLVGALPW 128
Cdd:pfam00031  81 G---LCSAQVYKVPW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 38-140 7.99e-25

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 91.34  E-value: 7.99e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3639092      38 INISNANVKQCVWFAMKEYNKESEDKYVFLVDKILHAKLQITDRMEYQIDVQISRSNCKKPLNNTENCIPQKKPElekkM 117
Cdd:smart00043   9 VPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQGE----K 84

                           90       100
                   ....*....|....*....|...
gi 3639092     118 SCSFLVGALPWNGEFNLLSKECK 140
Cdd:smart00043  85 FCTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 38-139 2.39e-22

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 84.83  E-value: 2.39e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3639092   38 INISNANVKQCVWFAMKEYNKESEDKYvFLVDKILHAKLQITDRMEYQIDVQISRSNCKKPLNNtENCIPQKKPELEKKM 117
Cdd:cd00042   6 IPANDPEVQELADFAVAEYNKKSNDKY-LEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVP-LDCPDCKLLEEGKKK 83

                        90       100
                ....*....|....*....|..
gi 3639092  118 SCSFLVGALPWNGEFNLLSKEC 139
Cdd:cd00042  84 FCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 36-128 1.36e-20

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 80.07  E-value: 1.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3639092     36 GSINISNA--NVKQCVWFAMKEYNKESeDKYVFLVDKILHAKLQITDRMEYQIDVQISRSNCKKPLNNTENCIPQKKPEL 113
Cdd:pfam00031   2 GLSPIPDNspELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEKWL 80

                          90
                  ....*....|....*
gi 3639092    114 EkkmSCSFLVGALPW 128
Cdd:pfam00031  81 G---LCSAQVYKVPW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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