|
Name |
Accession |
Description |
Interval |
E-value |
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
28-506 |
0e+00 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 871.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 28 SPIVHTDKTAKFDLPVDTEHKATVFKLFSFAKPHMRTFHLSWISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVAS 107
Cdd:PLN00028 1 QPASPDPKYSKFALPVDSEHKATEFRLFSFARPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 108 VSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITVRFMIGFCLATFVSCQYWMSTMFNSQIIGLV 187
Cdd:PLN00028 81 VSGSIFSRLAMGPVCDLYGPRYGSAFLLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 188 NGTAAGWGNMGGGITQLLMPIVYEIIRRCGSTAFTAWRIAFFVPGWLHIIMGILVLNLGQDLPDGNRATLEKAGEVAKDK 267
Cdd:PLN00028 161 NGIAAGWGNLGGGVTQLLMPLVFPLIKDAGAPSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPDGNYRELKKSGTMPKDS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 268 FGKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDFAAKYFG 347
Cdd:PLN00028 241 FSKVLRYGVTNYRTWILALTYGYSFGVELTMDNIIAEYFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARRFG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 348 MRGRLWTLWIIQTAGGLFCVWLGRANTLVTAVVAMVLFSMGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFGSGLTQ 427
Cdd:PLN00028 321 MRGRLWALWIVQTLGGVFCIWLGRANSLGAAIVVMILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQ 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3747058 428 LLFFSTSHFTTEQGLTWMGVMIVACTLPVTLVHFPQWGSMFLPPSTDPVkgtEAHYYGSEWNEQEKQKNMHQGSLRFAE 506
Cdd:PLN00028 401 LLFFTGSSYSTETGISLMGVMIIACTLPVAFIHFPQWGGMFFGPSKDAV---EEDYYASEWTEEEKEKGLHQGSLKFAE 476
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
65-458 |
1.05e-142 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 416.27 E-value: 1.05e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 65 FHLSWISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPR-YGCAFLVMLSAPTVF 143
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRrVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 144 SMSFVSDAAGFITVRFMIGFCLATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIRRcgSTAFTA 223
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVF--DGGFVG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 224 WRIAFFVPGWLHIIMGILVLNLGQDLPDGNRATLEkagevakdkFGKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIA 303
Cdd:cd17341 159 WRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALE---------FLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 304 EYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDFaakyFGMRGRLWTLWIIQTAGGLFCVWLGRANT--LVTAVVA 381
Cdd:cd17341 230 TYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDR----FGGRRRLWWLFIVMTIGAALLSLSLPTSGtnLVLFLAL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 3747058 382 MVLFSMGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFGSGLTQLLFFSTSH--FTTEQGLTWMGVMIVACTLPVTL 458
Cdd:cd17341 306 FVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALmtGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
63-422 |
7.00e-84 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 264.16 E-value: 7.00e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 63 RTFHLSWISFSTCFVSTFAAAPLVP-IIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAF-LVMLSAP 140
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVfLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALsLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 141 TVFSMSFVSDAAGFITVRFMIGFCLATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMP-IVYEIIRRCGST 219
Cdd:TIGR00886 81 CLWAGLAVQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPpIIGSLIFGGGQP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 220 AFTAWRIAF-FVPGWLHIIMGILVLNLGQDLPDGNRATLEKAGEVAKDKFGkilwyavtNYRTWIFVLLYGYSMGVELST 298
Cdd:TIGR00886 161 AHLAWGWAFvIVPAGILLLPALLIFFVGADTPPGKPATGKLSFKEALKVFG--------NRHTWILALLYSVTFGSFLGV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 299 DNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDFAAkyfgmRGRLWTLWIIQTAGGLFCVWLG--RANTLV 376
Cdd:TIGR00886 233 SSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLG-----GARKLLMNFLGVAMGAFLVVLGlvSDGSLA 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 3747058 377 TAVVAMVLFSMGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFG 422
Cdd:TIGR00886 308 AFIVLFVALFFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLG 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
59-430 |
3.22e-49 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 174.30 E-value: 3.22e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 59 KPHMRTFHLSWISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLS 138
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 139 APTVFSMSFVSDAAGFITVRFMIGFCL-ATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIrrcg 217
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 218 staftAWRIAFFVPGWLHIIMGILVLNLGQDLPDGNRATlekagevAKDKFGKILwYAVTNYRTWIFVLLYGYSMGVELS 297
Cdd:COG2223 157 -----GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA-------AKASLRDQL-EALRDPRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 298 TDNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDFaakyfgmRGRLWTLWIIQTAGGLFCVWLGRA-NTLV 376
Cdd:COG2223 224 FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR-------IGGRRVLLIVFALMALGLLLLALAlGSLW 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 3747058 377 TAVVAMVLFSMGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGLTQLLF 430
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPdIFPTKNAGAVYGLVGAAGGLGGFLGPLLF 351
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
59-459 |
4.35e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 100.71 E-value: 4.35e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 59 KPHMRTFHLSWISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLS 138
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 139 APTVFSMSFVSDAAGFITVRFMIGFCLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVyeiirrcg 217
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL-------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 218 sTAFTAWRIAFFVPGWLHIIMGILvlnlgqdlpdgnratlekagevakdkfgkilwyavtnyRTWIFVLLYGYSMGVELS 297
Cdd:COG2271 158 -LAAFGWRAAFLILGLPGLLLALL--------------------------------------RFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 298 TDNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDFAakyfgMRGRLWTLWIIQTAGGLFCVWLGRANTLVT 377
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL-----GRRRKLVLAIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 378 AVVAMVLFSMGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGLTQLLF-FSTSHFTTEQGLTWMGVMIVACTLP 455
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAeLFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAALALLAALL 353
|
....
gi 3747058 456 VTLV 459
Cdd:COG2271 354 ALLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
67-425 |
4.17e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.55 E-value: 4.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 67 LSWISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMS 146
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 147 FVSDAAGFITVRFMIGFCLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIRrcgstaftaWR 225
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG---------WR 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 226 IAFFVPGWLHIIMGILVLnlgqdLPDGNRATLEKAGEVAKDKFGKILWYAVTNYRtWIFVLLYGYSMGVELSTDNVIAEY 305
Cdd:pfam07690 152 AAFLILAILSLLAAVLLL-----LPRPPPESKRPKPAEEARLSLIVAWKALLRDP-VLWLLLALLLFGFAFFGLLTYLPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 306 FFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDfaakYFGMRGRLWTLWIIQTAGGLFCVWLGRANTLVTAVVAMVLF 385
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 3747058 386 SMGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGL 425
Cdd:pfam07690 302 GFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
69-425 |
1.68e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 83.87 E-value: 1.68e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 69 WISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFV 148
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 149 SDAAGFITVRFMIGFCLATFVS-CQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIrrcgstaftAWRIA 227
Cdd:COG2814 96 PSLWLLLAARFLQGLGAGALFPaALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---------GWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 228 FFVPGWLHIIMGILVLnlgqdlpdgnrATLEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYFF 307
Cdd:COG2814 167 FLVNAVLALLALLLLL-----------RLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 308 DRFHLKLHTAGLIAACFGMANFFARPAGGYASDFaakyfgmRGRLWTLWIIQTAGGLFCVWLGRANTLVTAVVAMVLFSM 387
Cdd:COG2814 236 EVLGLSASAAGLLLALFGLGGVLGALLAGRLADR-------FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGF 308
|
330 340 350
....*....|....*....|....*....|....*....
gi 3747058 388 GAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGL 425
Cdd:COG2814 309 GFGLLFPLLQALVAeLAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
69-458 |
6.67e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 82.47 E-value: 6.67e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 69 WISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGC-AFLVMLSAPTVFsMSF 147
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLlLGLLLFALGALL-FAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 148 VSDAAGFITVRFMIGFCLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIrrcgstaFTAWRI 226
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSL-------GFGWRA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 227 AFFVPGWLHIIMGILVLNLgqdLPDGNRATLEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAEYF 306
Cdd:cd06174 154 VFLIAAALALLAAILLLLV---VPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 307 FDRFHLKLHTAGLIAACFGMANFFARPAGGYASDFAakyfgmRGRLWTLWIIQTAGGLFCVWLGRANTLVTAVVAMVLFS 386
Cdd:cd06174 231 LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRL------IGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 3747058 387 MGAQAACGATFAIVPF-VSRRALGIISGLTGAGGNFGSGLTQLLF-FSTSHFTTEQGLTWMGVMIVACTLPVTL 458
Cdd:cd06174 305 FGLGGLLPLSFALIAElFPPEIRGTAFGLLNTFGFLGGAIGPLLAgFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
61-459 |
6.82e-11 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 63.83 E-value: 6.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 61 HMRTFHLSWISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAP 140
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 141 TVFSMSFVSDAAGFITVRFMIGFCLAT-FVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIvyeIIRRCGst 219
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMgWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAAS---LASYYG-- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 220 aftaWRIAFFVPGWLHIIMGILVLNLGQDLPDGnratlekagevakdkfgkilwyavtnyrTWIFVLLYGYSMGVELSTD 299
Cdd:cd17312 156 ----WRAAFLVPGIVGLVVAIILFFFLRDSPPY----------------------------VWVLSLAYAFVYIVRYACL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 300 NVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDfaaKYFGMRGRLWTLWIIQTAGGLFCVWLGRANTLVTAV 379
Cdd:cd17312 204 DWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSD---KLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSI 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 380 VAMVL--FSMGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFGSGLTQLLFfstSHFTteQGLTWMGV---MIVACTL 454
Cdd:cd17312 281 VLLFLigFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPL---GYII--DHYGWSTVfyfLISAALL 355
|
....*
gi 3747058 455 PVTLV 459
Cdd:cd17312 356 SVLLL 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
87-430 |
1.95e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 62.59 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 87 PIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYG-CAFLVMLSAPTVFsMSFVSDAAGFITVRFMIGFCL 165
Cdd:cd17319 27 PTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVlAVSMLLWSLFTAL-TGFATSLTSLYVLRFLLGVAE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 166 ATFVSC-----QYWMSTMFNSQIIGLVNgTAAGWGNMgggitqLLMPIVYEIIrrcgsTAFTaWRIAFFVPGWLHIIMGI 240
Cdd:cd17319 106 AGFFPGaikalAEWFPARERGRATGLFN-SGAPLGAA------IGPPLSGWLL-----LLFG-WRWAFIIEGLLGLLLAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 241 LVLNLGQDLpdgnratlekagevakdkFGKILWYAVTNYRTWIFVLLygysmgvelstdnvIAEYFFDRFHLKLHTAGLI 320
Cdd:cd17319 173 LWWFYLRQV------------------WGLALGYFGINYALYGLLTW--------------LPTYLKQARGFSLKQVGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 321 AACFGMANFFARPAGGYASDFaakyFGMRGRLWTLWIIQTAGGLFCVWLGRANTLVTAVVAMVLFSMGAQAACGATFAIV 400
Cdd:cd17319 221 AAIPFLAGAIGMILGGRLSDR----LLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLP 296
|
330 340 350
....*....|....*....|....*....|.
gi 3747058 401 P-FVSRRALGIISGLTGAGGNFGSGLTQLLF 430
Cdd:cd17319 297 AdLLPGEAAATAGGLINSGGNLGGFVAPLLI 327
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
68-430 |
2.76e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 62.26 E-value: 2.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 68 SWISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSF 147
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 148 VSDAAGFITVRFMIGFCLATFV-SCQYWMSTMFNSQIIGLVNG---TAAgwgNMGGGITQLLMPIVyeiirrcgstAFTA 223
Cdd:cd17475 81 VGSYPVLLVLLFLVGAGYGSVQpGGGRAIMRWFPPRERGLAMGirqTGV---PLGGALAAALLPPL----------ALHY 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 224 -WRIAFFVPGWLHIIMGILVLNLGQDLPDGNRATLEKAGEVAKDKfgkilwyAVTNYRTWIFVLLYGYSM-GVELSTDNV 301
Cdd:cd17475 148 gWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSLK-------EVLRNRDVWLIAIAGALLvAPQFALLTF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 302 IAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDfaaKYFGMRGRLWTLWIIQTAGGLFCV--WLGRANTLVTAV 379
Cdd:cd17475 221 LLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSD---RVFGGRRRPVLVITAAIAAAALLVlsLLSPGTPLWLLV 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 3747058 380 VAMVLFSMGAQAACGATFA-IVPFVSRRALGIISGLTGAGGNFGSGLTQLLF 430
Cdd:cd17475 298 LLLILLGLFAIGWNGLYLTlVAESAGPEQAGTALGLANTINFIGIAIGPPLF 349
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
69-430 |
3.06e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.01 E-value: 3.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 69 WISFSTCFV--STFAAAplVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMS 146
Cdd:TIGR00881 1 FIGYAAYYLvrKNFALA--MPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 147 FVSDAAGFITVRFMIGFCLAT-FVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGItqlLMPIVYEIIRRCGStaftaWR 225
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMgWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGL---LPPLVLFGIAELYS-----WH 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 226 IAFFVPGWLHIIMGILVLNLGQDLP-------------DGNRATLEKAGEVAKDKFGKiLWYAVTNYRTWIFVLLYGYSM 292
Cdd:TIGR00881 151 WVFIVPGIIAIIVSLICFLLLRDSPqscglppaeempnEEPDGDAEKKEEELTKKQIF-LQYVLLNKVLWYISLGYVFVY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 293 GVELSTDNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASD--FAAKYFGMrGRLWTLWIIQTAGGLFCVwlG 370
Cdd:TIGR00881 230 VVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDklFNGRRGPL-AVFFMALIIVSLLVYWLN--P 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3747058 371 RANTLVTAVVAMVL--FSMGAQAACGAtfAIVPFVSRRALGIISGLTGAGGNFGSGLTQLLF 430
Cdd:TIGR00881 307 AANPLMDLICLFALgfLVYGPQMLIGV--IASELAPKKAAGTAAGFVGFFAYLGGILAGLPL 366
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-418 |
1.15e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.25 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 59 KPHMRTFHLSWISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLS 138
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 139 APTVFSMSFVSDAAGFITVRFMIGFCLATF-VSCQYWMSTMFN---SQIIGLVNGtaagwGNMGGGItqlLMPIVYEIIR 214
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAALGPetaASRLNLLHA-----FFSLGAL---LGPLLGGLLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 215 RCGSTAftAWRIAFFVPGWLHIIMGILVlnLGQDLPDGNRATLEKAGEVAKDKFgkilwyAVTNYRTWIFVLLYGYSMGV 294
Cdd:COG0738 156 LLGLSL--SWHLPYLILAVLLLLLALLF--LRSKLPEIEEEEEEAAGSAASLKS------LLKNPRLLLGGLAIFLYVGA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 295 ELSTDNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDFAakyfgmrGRLWTLWIIQTAGGLFCVWLGRANT 374
Cdd:COG0738 226 EGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-------GPVRLLRLSALLAAVGLLLALLAPG 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 3747058 375 LVTAVVAMVLFSMGAQAACGATFAIVP-FVSRRALGIISGLTGAG 418
Cdd:COG0738 299 PWLALIGLALVGLGLSLMFPTIFSLALdGLGKRTAAAVSAVLIMG 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
112-451 |
2.65e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.06 E-value: 2.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 112 IFSRLVMGAVCDLLGPRYG--------CAFLVMLSAPTVFSMSFVSDAAGFITvrFMIGFCLATFVScqywmsTMFNSQI 183
Cdd:COG2211 60 AITDPLIGALSDRTRTRWGrrrpwiliGAIPLALSFVLLFTAPDLSPTGKLIY--ALVTYLLLGLAY------TLVNIPY 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 184 IGLVN---------GTAAGWGNMGGGITQLLMPIV-YEIIRRCGSTAFTAWRIAFFVPGWLHIIMGILVLnlgqdlpdgn 253
Cdd:COG2211 132 SALGAeltpdyeerTRLSSWRFAFAGLGGLLASVLpPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTF---------- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 254 RATLEK-AGEVAKDKFGKILWYAVTNyRTWIFVLLYGYSMGVELSTDNVIAEYFF-DRFHLKLHTAGLIAACFGMANFFA 331
Cdd:COG2211 202 FGTKERpVPEEEKVSLKESLKALLKN-RPFLLLLLAYLLFFLALALVAALLLYYFkYVLGLSAALVGLLLALYFLAALLG 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 332 RPAGGyasdFAAKYFGMRgRLWTLWIIQTAGGLFCVWLGRANTLVTAVVAMVLFSMGAQAACGATFAIVPFVS------- 404
Cdd:COG2211 281 APLWP----RLAKRFGKK-KAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewkt 355
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 3747058 405 -RRALGIISGLTGAGGNFGSGLTQLLF--------FSTSHFTTEQGLTWMGVMIVA 451
Cdd:COG2211 356 gRRREGLYFGIFTFAIKLGQALAGALAglllalfgYVAGAAQSPSALTGIRLLFFL 411
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
101-250 |
5.06e-07 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 52.02 E-value: 5.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 101 GNAGVASVSGSI---FSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITVRFMIGF------------CL 165
Cdd:PRK11273 63 GDLGFALSGISIaygFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWATSSIAVMFVLLFlcgwfqgmgwppCG 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 166 ATFVscqYWMSTMFNSQIIGLVNGTAagwgNMGGGITQLLMPIvyeiirrcGSTAFTAWRIAFFVPGWLHIIMGILVLNL 245
Cdd:PRK11273 143 RTMV---HWWSQKERGGIVSVWNCAH----NVGGGLPPLLFLL--------GMAWFNDWHAALYMPAFAAILVALFAFAM 207
|
....*
gi 3747058 246 GQDLP 250
Cdd:PRK11273 208 MRDTP 212
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
69-454 |
7.39e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.42 E-value: 7.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 69 WISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYgcaFLVM---LSAPTVFSM 145
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKR---LLLLgllLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 146 SFVSDAAGFITVRFMIGFCLA-TFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEiirrcgstaFTAW 224
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD---------ALGY 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 225 RIAFFVPGWLHIIMGILVLNLgqdLPDGNRAtlEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSMGVELSTDNVIAE 304
Cdd:cd17325 150 RAPFLVCAALALLALVLALLL---LPEPRPP--PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 305 YFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDfaakyfgMRGRLWTLWIIQTAGGLFCVWLGRANTLVTAVVAMVL 384
Cdd:cd17325 225 YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD-------RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLAL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3747058 385 FSMGAQAACGATFAIV-PFVSRRALGIISGLTGAGGNFGSGLTQLLF-FSTSHFTTEQGLTWMGVMIVACTL 454
Cdd:cd17325 298 LGLGLGLVFPATLALLaDIVPPEGRGTAMGLFNTAFSLGMVLGPLLGgFLYDAFGFATPFLAAAALLLLAAV 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
69-425 |
8.70e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.01 E-value: 8.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 69 WISFSTCFV---STFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSM 145
Cdd:cd17324 2 LALALAAFAigtTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 146 SFVSDAAGFITVRFMIGFCLATFVSCQY-WMSTMFNSQIIGLVNGTAAGwGNMGGGIT-QLLMPIVyeiirrcgsTAFTA 223
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAaYAADLVPPEKRGRAIGLVFS-GLTLGLVLgRPLGGLL---------GQLLG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 224 WRIAFFVPGWLHIIMGILVLNLGQDLPDGNRATLEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSmgvelstdnVIA 303
Cdd:cd17324 152 WRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYT---------YLA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 304 EYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDfaakYFGMRGRLWTLWIIQTAGGLFCVWlgrANTLVTAVVAMV 383
Cdd:cd17324 223 PFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD----RGGRRALLIALLLLAAALLLLTLL---GPSPLLLLVGLV 295
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 3747058 384 LFSMGAQAACGATFAIVPFVSRRALGIISGLTGAGGNFGSGL 425
Cdd:cd17324 296 LWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGAL 337
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
76-458 |
1.46e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.29 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 76 FVSTFAAAPLVPIIreNLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAF-LVMLSAPTVFSMsFVSDAAGF 154
Cdd:cd17316 16 FLIGFVAPVLAAEF--SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILtLLLFGLATLLIG-LLPTPILL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 155 ITVRFMIGFCL-ATFVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVYEIIrrcgsTAFTAWRIAFFVPGW 233
Cdd:cd17316 93 LVLRFLQGIGIgGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL-----SGDWGWRILFLIGAL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 234 LHIIMGILVLNLgqdlpdgnratlekagevakdkfgkILWYAVtnyrtWIFVLLYGYSMGVELSTdnviaeYFFDRFHLK 313
Cdd:cd17316 168 PALLALLLRRRT-------------------------LLLILL-----WFFISFGYYGLTTFLPT------YLQTVLGLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 314 LHTAGLIAACFGMANFFARPAGGYASDfaakyfgMRGRLWTLWIIQTAGGLFCVWLGRA-----NTLVTAVVAMVLFSMG 388
Cdd:cd17316 212 PATSSLYLLLISLGALVGALIAGLLSD-------RIGRKKTLVIGLILSGILALPLFYLlsgspTLLLLLLFILSFFVGG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3747058 389 AQAACGATFAIVPFVSRRALGiiSGLTGAGGNFGSGLTQLLFFST-SHFTTEQGLTWMGVMIVACTLPVTL 458
Cdd:cd17316 285 VWGALYAYLAELFPTEVRATG--VGLSYNLGRLGGGGAPPLIALLlASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
75-461 |
7.38e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 48.36 E-value: 7.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 75 CFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGF 154
Cdd:cd17489 8 FFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 155 ITVRFMIGFCLATFVSCqywMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVyeiirrcGSTAFTAWriAFFVPGWL 234
Cdd:cd17489 88 LVLRLIHGIGWGAFTTA---AATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL-------GLFLYQHL--GFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 235 HIIMGILVLNLGQDLPDGNRAtLEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSmgvelSTDNVIAEYFFDRFHlkl 314
Cdd:cd17489 156 AAVLALLALLLVFLVKDPPPV-AAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYG-----AISTFLPLYAAERGI--- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 315 HTAGLIAACFGMANFFARPaggyasdFAAKYFGMRGRLWTLWIIQTAGGLFCVWLGRANTLVTAVVAMVLFSMG---AQA 391
Cdd:cd17489 227 SNAGLFFTVYAIALLLSRP-------FSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGfglLFP 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 392 ACGAtfAIVPFVSRRALGIISGLTGAGGNFGSGLTQLLFFSTSHFTTEQGLTWMGVMIVACTLPVTLVHF 461
Cdd:cd17489 300 ALQA--LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
87-250 |
1.29e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 47.62 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 87 PIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITVRFMIGFCLA 166
Cdd:cd17345 27 PYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFILLFLNG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 167 TFVS-----CQYWMSTMFNSQIIGlvnGTAAGWG---NMGGGITQLLMPIvyeiirrcGSTAFTA--WRIAFFVPGWLHI 236
Cdd:cd17345 107 WFQGmgwppSGRTMVHWFSKKERG---TWTSIWNishNVGGGLVGPLAGL--------GLAIFGDgwWRGAFIFPAIIAI 175
|
170
....*....|....
gi 3747058 237 IMGILVLNLGQDLP 250
Cdd:cd17345 176 IVAVIVLFLGKDTP 189
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
125-294 |
1.64e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 44.16 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 125 LGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITVRFMIGFCLA-TFVSCQYWMSTMFNSQIIGLVNG---TAAGWGNMGGG 200
Cdd:cd17327 68 FPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESgVFPGFILYLGMWYKREEQAKRIAffyAAAGLGSIFGG 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 201 ItqllmpIVYEIIRRCGSTAFTAWRIAFFVPGWLHIIMGILVLNLGQDLPDGNRATLEKAGEVAK------------DKF 268
Cdd:cd17327 148 L------LAYGVFKILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVerlranqtgkgdQKF 221
|
170 180
....*....|....*....|....*..
gi 3747058 269 G-KILWYAVTNYRTWIFVLLYGYSMGV 294
Cdd:cd17327 222 KwKQIKEAFKDPRTWLLFLFFFCSQIT 248
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
69-430 |
2.05e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.85 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 69 WISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFV 148
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 149 SDAAGFITVRFMIGFCLATFVSCQY-WMSTMFNSQiiglvNGTAAGWGNMGGGITQLLMPIVYEIIrrcgSTAFTAWRIA 227
Cdd:cd17333 82 PSIYLFVVLMFLAGLGAGILDTGANtFVGALFEES-----SATRLNVLHGFFGLGALIGPLIATSL----LTSELSWSWA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 228 FFVPGWLHIIMGILVLNLGQDLPDGNRATLEKAGEVAKDKFGKILwyavtNYRTWIFVLLYGYSMGVELSTDNVIAEYFF 307
Cdd:cd17333 153 YLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLR-----NPSIILGALALFLYVGAETAFSSWVPSYLV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 308 DRFHLKLHTAGLIAACFGMANFFARPAGGYASDfaakyfgmRGRLWTLWIIQTAGG-LFCVWLGRANTLVTAVVAMVL-- 384
Cdd:cd17333 228 EKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR--------RIKPHTLLVLSGSGAlLGLLILLLAPTLVVGLVATALlg 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 3747058 385 FSMGAQAACGATFAI--VPFVSRRALGIISGLTGAGGNFGSGLTQLLF 430
Cdd:cd17333 300 LFMAALFPTILSLGIsnLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIA 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
275-430 |
4.81e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.55 E-value: 4.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 275 AVTNYRTWIFVLL---YGYSMGVELSTdNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDfaakYFGMRgr 351
Cdd:COG2271 3 APSRYRWRILALLflaYFLNYLDRSNL-SVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD----RFGRR-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 352 lWTLWIIQTAGGLFCVWLGRANTLVTAVVAMVLFSMGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGLTQLLF 430
Cdd:COG2271 76 -RVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAeWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
285-461 |
9.07e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 41.64 E-value: 9.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 285 VLLYGYSMGVELSTDNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDfaakYFGMRgrlWTLWIIQTAGGL 364
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGRR---PVLLLGLLLFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 365 FCVWLGRANTLVTAVVAMVLFSMGAQAACGATFAIVP-FVSRRALGIISGLTGAGGNFGSGLTQLLFFSTSHFTTeQGLT 443
Cdd:cd06174 74 GALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIAdLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-FGWR 152
|
170
....*....|....*...
gi 3747058 444 WMGVMIVACTLPVTLVHF 461
Cdd:cd06174 153 AVFLIAAALALLAAILLL 170
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
86-388 |
1.60e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 40.85 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 86 VPIIRENLNLTKQDIGnagvasVSGSIF------SRLVMGAVCDLLGPRYGCAFLVMLSAPTVFSMSFVSDAAGFITVRF 159
Cdd:cd17488 26 MPAMLADLGLDKSDIG------ILGSLFyitygvSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFAVLWT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 160 MIGFCLAT-FVSCQYWMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIVyeiirrcgsTAFTAWRIAFFVPGWLHIIM 238
Cdd:cd17488 100 LNAFFQGWgWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFA---------ALTYGWRAGMYVPGIIAILM 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 239 GILVLNLGQDLPdgnratlekagevakdkfgKILWYAVTNYrtwifVLLYGYSMGVelstDNVIAEYFFDRFHLKLHTAG 318
Cdd:cd17488 171 GIVLCWRLRDRP-------------------PYIWLLAFCY-----VLVYVVRTAI----NDWGNLYLSETHGYSLVKAN 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 3747058 319 LIAACFGMANFFARPAGGYASDfaaKYFgmRGRLWTLWIIQTAGGLFCV---WLGRANTLVtaVVAMVLFSMG 388
Cdd:cd17488 223 SAVSLFEVGGLIGALVAGWGSD---KLF--KGNRGPMNLIFALGLLVSVgalWLVPVHSYW--LLATCFFTIG 288
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
277-464 |
2.88e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.22 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 277 TNYRTWIFVLLYGY-SMGVELSTDNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYasdFAAKYFGMRGRLWTL 355
Cdd:COG0738 4 KNYRRALIAIYLLFfLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGR---LIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 356 WIIqtagGLFCVWLGRANTLVTAVVAMVLFSMGA---QAACGATFAIV-PFVSRRALGIISGLTGAGGNFGSGLTQLLFF 431
Cdd:COG0738 81 LLM----ALGLLLFALAPSYPLLLLALFLLGLGLgllDVAANPYVAALgPETAASRLNLLHAFFSLGALLGPLLGGLLIL 156
|
170 180 190
....*....|....*....|....*....|...
gi 3747058 432 STSHFTTEQGLTWMGVMIVACTLPVTLVHFPQW 464
Cdd:COG0738 157 LGLSLSWHLPYLILAVLLLLLALLFLRSKLPEI 189
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
67-230 |
4.28e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 4.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 67 LSWISFSTCFVSTFAAAPLvpIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPR--YGCAFLVMLSAPTVFS 144
Cdd:cd17316 184 LLWFFISFGYYGLTTFLPT--YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKktLVIGLILSGILALPLF 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 145 MSFVSDAAGFITVRFMIGFCLATFVSCQY-WMSTMFNSQIIGLVNGTAAGWGNMGGGITQLLMPIvyeIIRRCGSTAFTA 223
Cdd:cd17316 262 YLLSGSPTLLLLLLFILSFFVGGVWGALYaYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIAL---LLASTGGTGVPA 338
|
....*..
gi 3747058 224 WRIAFFV 230
Cdd:cd17316 339 LILALLA 345
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
58-356 |
5.82e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.02 E-value: 5.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 58 AKPHMRTFHLSWISFSTCFVSTFAAAPLVPIIRENLNLTKQDIGNAGVASVSGSIFSRLVMGAVCDLLGPRYgcAFLVML 137
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR--VLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 138 SAPTVFS--MSFVSDAAGFITVRFMIGFCLAT-FVSCQYWMSTMFNSQIIGLvngtAAGWGNMGGGITQLLMPIVYEIIr 214
Cdd:COG0477 87 LLFGLASllCGLAPSPELLIAARALQGIGAGGlMPGALALIAELFPARERGR----ALGLWGAAIGLGLALGPLLGGLL- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 215 rcgsTAFTAWRIAFfvpgWLHIIMGILVLNLGQDLPDGNRATLEKAGEVAKDKFGKILWYAVTNYRTWIFVLLYGYSMGV 294
Cdd:COG0477 162 ----VAALGWRWIF----LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALL 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 3747058 295 ELSTDNVIAEYFFDRFHLKLHTAGLIAACFGMANFFARPAGGYASDFAAKYFGMRGRLWTLW 356
Cdd:COG0477 234 LAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
40-417 |
8.83e-03 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 38.49 E-value: 8.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 40 DLPVDTEHKAtvfklfsFAKPHMRTFHLSWISFSTCFV--STFAAAPlvPIIRENLNLTKQDIGNAGVASVSGSIFSRLV 117
Cdd:PRK09556 13 DLPLEVQRKM-------WFKPFMQSYLVVFIGYLTMYLirKNFKAAQ--NDMISTYGLSTTELGMIGLGFSITYGVGKTL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 118 MGAVCDLLGPRYGCAFLVMLSAPTVFSMSFvSDAAGFITVRFMI------GFCLATFVSCQY-----WMSTMFNSQIIGL 186
Cdd:PRK09556 84 VGYYADGKNTKQFLPFLLILSAICMLGFGA-SLGSGSVSLGLMIalwalsGFFQSTGGPCSYstitrWTPRRKRGRFLGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 187 VNgTAAGWGNMGGGITQLLmpivyeiirrcGSTAFTAWRIA--FFVPGWLHIIMGILVLNLGQDLPDG---NRATlEKAG 261
Cdd:PRK09556 163 WN-ISHNLGGAGAGGVALW-----------GANYFFDGHVIgmFIFPSIIALIIGFIGLRYGSDSPEElgwGKAE-EIFG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 262 EVAKD-----------KFGKILWYAVTNYRTWIF----VLLYGYSMGVelstDNVIAEYFFDRFHLKLHTAGLIAACFGM 326
Cdd:PRK09556 230 EPISEedketestdmtKWQIFVEYVLKNPVIWLLcfanIFLYIVRIGI----DNWSPVYAFQELGFSKEDAINTFTLFEI 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 327 ANFFARPAGGYASDFaakyfgMRGRLWTLWIIQTAGGLFCVWLGRANTLVTAVVAmVLFSMGA-----QAACGAtfAIVP 401
Cdd:PRK09556 306 GALVGSLLWGWLSDL------ANGRRALVACIALALIIFTLGVYQHATSEYMYLA-SLFALGFlvfgpQLLIGV--AAVG 376
|
410
....*....|....*.
gi 3747058 402 FVSRRALGIISGLTGA 417
Cdd:PRK09556 377 FVPKKAIGVANGIKGT 392
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
132-425 |
9.05e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 9.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 132 AFLVMLSAPTVFSMSFVSDAAGFI--TVRFMIGFCLATFVSCQYW-----MSTmfNSQIIGLVNGTAAGWGNMGGGITQL 204
Cdd:cd17332 77 AIPLALLFVLLFTTPDGSGTGKLIyaLITYILLDLLYTLVNIPYTalipeLTD--DPEERTSLTSWRMFFATIGGLLVTV 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 205 LMPIVYEIIRrcGSTAFTAWRIAFFVPGwlhIIMGILVLNLGQDLPDGNRATLEKAGEVakdKFGKILWYAVTNyRTWIF 284
Cdd:cd17332 155 LPPPLVAYFG--GGNASRGYFLTALIIG---IIGIILLLICFFGTRERVVPPEEEKSKL---PLLKSLKALLKN-RPFLI 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 3747058 285 VLLYGYSMGVELSTDNVIAEYFFDrFHLKLHTAGLIaacFGMANFFARPAGGYASDFAAKYFGmrgRLWTLWIIQTAGGL 364
Cdd:cd17332 226 LLLAYLLYFLAFNIVNTVLVYYFK-YVLGGRAELVL---LLLLILSGALLALLPWPPLKKRFG---KKKAFFIGLLLAIL 298
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 3747058 365 FCV--WLGRANTLVTAVVAMVLFSMGAQAACGATFAIVPFVS--------RRALGIISGLTGAGGNFGSGL 425
Cdd:cd17332 299 GLLllFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIdygelktgKRREGIFYSVMTFFRKLGLAL 369
|
|
| |
