NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4262075|gb|AAD14375|]
View 

Unknown, partial [Homo sapiens]

Protein Classification

LamG domain-containing protein( domain architecture ID 366259)

LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LamG super family cl22861
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1-74 6.30e-14

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


The actual alignment was detected with superfamily member pfam00054:

Pssm-ID: 473984 [Multi-domain]  Cd Length: 131  Bit Score: 63.10  E-value: 6.30e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4262075      1 VSVEELEHSISIKIAKEAVMDINKP-GPLFKPengLLETKVYFAGFPRKVESELIKPINPRLDGCIR--SWNLMKQG 74
Cdd:pfam00054  58 VELERNGRSGTLSVDGEARPTGESPlGATTDL---DVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRdvIVNGKPLD 131
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1-74 6.30e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 63.10  E-value: 6.30e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4262075      1 VSVEELEHSISIKIAKEAVMDINKP-GPLFKPengLLETKVYFAGFPRKVESELIKPINPRLDGCIR--SWNLMKQG 74
Cdd:pfam00054  58 VELERNGRSGTLSVDGEARPTGESPlGATTDL---DVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRdvIVNGKPLD 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1-70 1.26e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 41.63  E-value: 1.26e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4262075    1 VSVEELEHSISIKIAKEAVMDINKPGplfKPENGLLETKVYFAGFPRKVESELIkPINPRLDGCIRSWNL 70
Cdd:cd00110  85 VSVERNGRSVTLSVDGERVVESGSPG---GSALLNLDGPLYLGGLPEDLKSPGL-PVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
1-70 5.74e-04

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 36.93  E-value: 5.74e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4262075       1 VSVEELEHSISIKIAKEAVMDINKPGplfKPENGLLETKVYFAGFPRkVESELIKPINPRLDGCIRSWNL 70
Cdd:smart00282  64 VAVERNGRSVTLSVDGGNRVSGESPG---GLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKV 129
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1-74 6.30e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 63.10  E-value: 6.30e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4262075      1 VSVEELEHSISIKIAKEAVMDINKP-GPLFKPengLLETKVYFAGFPRKVESELIKPINPRLDGCIR--SWNLMKQG 74
Cdd:pfam00054  58 VELERNGRSGTLSVDGEARPTGESPlGATTDL---DVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRdvIVNGKPLD 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1-70 1.26e-05

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 41.63  E-value: 1.26e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4262075    1 VSVEELEHSISIKIAKEAVMDINKPGplfKPENGLLETKVYFAGFPRKVESELIkPINPRLDGCIRSWNL 70
Cdd:cd00110  85 VSVERNGRSVTLSVDGERVVESGSPG---GSALLNLDGPLYLGGLPEDLKSPGL-PVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
1-70 5.74e-04

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 36.93  E-value: 5.74e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4262075       1 VSVEELEHSISIKIAKEAVMDINKPGplfKPENGLLETKVYFAGFPRkVESELIKPINPRLDGCIRSWNL 70
Cdd:smart00282  64 VAVERNGRSVTLSVDGGNRVSGESPG---GLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKV 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH