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Conserved domains on  [gi|4981363|gb|AAD35913|]
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branched-chain amino acid aminotransferase, putative [Thermotoga maritima MSB8]

Protein Classification

aminotransferase class IV( domain architecture ID 10087399)

aminotransferase class IV family protein similar to Thermotoga maritima probable branched-chain amino acid aminotransferase IlvE which may catalyze the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 29-259 4.53e-76

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


:

Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 231.72  E-value: 4.53e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   29 AVYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKAG-ADEFKQEVRIKVYLFPDSGEVLFVFSPLNIP 107
Cdd:cd00449   9 GVFEGLRAGKGRLFRLDEHLDRLNRSAKRLGLPIPYDREELREALKELvAANNGASLYIRPLLTRGVGGLGVAPPPSPEP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  108 DL--------------ETGVEVKISNVRRIPDLSTPPALKITGRTDIVLARREIVD--CYDVILLGLNGQVCEGSFSNVF 171
Cdd:cd00449  89 TFvvfaspvgayakggEKGVRLITSPDRRRAAPGGTGDAKTGGNLNSVLAKQEAAEagADEALLLDDNGYVTEGSASNVF 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  172 LVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHSFFEEEPGPV 251
Cdd:cd00449 169 IVKDGELVTPPLDGGILPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTAAEVTPVTEIDGRGIGDGKPGPV 248


                ....*...
gi 4981363  252 TATLMENF 259
Cdd:cd00449 249 TRKLRELL 256
 
Name Accession Description Interval E-value
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 29-259 4.53e-76

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 231.72  E-value: 4.53e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   29 AVYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKAG-ADEFKQEVRIKVYLFPDSGEVLFVFSPLNIP 107
Cdd:cd00449   9 GVFEGLRAGKGRLFRLDEHLDRLNRSAKRLGLPIPYDREELREALKELvAANNGASLYIRPLLTRGVGGLGVAPPPSPEP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  108 DL--------------ETGVEVKISNVRRIPDLSTPPALKITGRTDIVLARREIVD--CYDVILLGLNGQVCEGSFSNVF 171
Cdd:cd00449  89 TFvvfaspvgayakggEKGVRLITSPDRRRAAPGGTGDAKTGGNLNSVLAKQEAAEagADEALLLDDNGYVTEGSASNVF 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  172 LVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHSFFEEEPGPV 251
Cdd:cd00449 169 IVKDGELVTPPLDGGILPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTAAEVTPVTEIDGRGIGDGKPGPV 248


                ....*...
gi 4981363  252 TATLMENF 259
Cdd:cd00449 249 TRKLRELL 256
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 1-260 1.65e-73

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 226.22  E-value: 1.65e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    1 MLIWWRGKFRRADEISLdfSLFEKSLQ-G-AVYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKAGAD 78
Cdd:COG0115   1 RLIWLNGELVPEEEATI--SVLDRGLHyGdGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   79 EFK-QEVRIKVYLF----------PDSGEVLFVF-SPLNIPD---LETGVEVKISNVRRIPDlSTPPALKITGRTDIVLA 143
Cdd:COG0115  79 ANGlEDGYIRPQVTrgvggrgvfaEEYEPTVIIIaSPLPAYPaeaYEKGVRVITSPYRRAAP-GGLGGIKTGNYLNNVLA 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  144 RREIVD--CYDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEAD 221
Cdd:COG0115 158 KQEAKEagADEALLLDTDGYVAEGSGSNVFIVKDGVLVTPPLSGGILPGITRDSVIELARELGIPVEERPISLEELYTAD 237

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4981363  222 EMFLTHTSAGVVPVRRLNEHSFFEEEPGPVTATLMENFE 260
Cdd:COG0115 238 EVFLTGTAAEVTPVTEIDGRPIGDGKPGPVTRRLRELYT 276
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 29-238 8.75e-56

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 178.71  E-value: 8.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363     29 AVYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKAGADEFKQEV-RIKVYLFPDSGEVLFVFSPLNI- 106
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGVgRLRLTVSRGPGGFGLPTSDPTLa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    107 -------PDLETGVEVKISNVRRIPDLSTPPALKITGRTDIVLARREIV--DCYDVILLGLNGQVCEGSFSNVFLVKEGK 177
Cdd:pfam01063  81 ifvsalpPPPESKKKGVISSLVRRNPPSPLPGAKTLNYLENVLARREAKaqGADDALLLDEDGNVTEGSTSNVFLVKGGT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4981363    178 LITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRL 238
Cdd:pfam01063 161 LYTPPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
PRK06606 PRK06606
branched-chain amino acid transaminase;
29-259 8.97e-46

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 155.69  E-value: 8.97e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    29 AVYETLRTY----SRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKagadEFKQEVRIK-VYLFPdsgevlFVF-- 101
Cdd:PRK06606  35 GVFEGIRAYdtpkGPAIFRLREHTKRLFNSAKILRMEIPYSVDELMEAQR----EVVRKNNLKsAYIRP------LVFvg 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   102 ------SPLNIPD-----------------LETGVEVKISNVRRIPDLSTPPALKITGR-TDIVLARREIVDC-YD-VIL 155
Cdd:PRK06606 105 deglgvRPHGLPTdvaiaawpwgaylgeeaLEKGIRVKVSSWTRHAPNSIPTRAKASGNyLNSILAKTEARRNgYDeALL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   156 LGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPV 235
Cdd:PRK06606 185 LDVEGYVSEGSGENIFIVRDGVLYTPPLTSSILEGITRDTVITLAKDLGIEVIERRITRDELYIADEVFFTGTAAEVTPI 264

                        250       260
                 ....*....|....*....|....
gi 4981363   236 RRLNEHSFFEEEPGPVTATLMENF 259
Cdd:PRK06606 265 REVDGRQIGNGKRGPITEKLQSAY 288
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 29-259 2.88e-39

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 138.65  E-value: 2.88e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363     29 AVYETLRTY----SRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKA------------------GADEFKqeVRI 86
Cdd:TIGR01122  26 GVFEGIRAYdtdkGPAIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATREtlrknnlrsayirplvfrGDGDLG--LNP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363     87 KVYLFPDSGEVLFVFSP-LNIPDLETGVEVKISNVRRIPDLSTPPALKITGR-TDIVLARREIVDC-YD-VILLGLNGQV 162
Cdd:TIGR01122 104 RAGYKPDVIIAAWPWGAyLGEEALEKGIDAKVSSWRRNAPNTIPTAAKAGGNyLNSLLAKSEARRHgYDeAILLDVEGYV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    163 CEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHS 242
Cdd:TIGR01122 184 AEGSGENIFIVKDGVLFTPPVTSSILPGITRDTVITLAKELGIEVVEQPISREELYTADEAFFTGTAAEITPIREVDGRK 263

                         250
                  ....*....|....*..
gi 4981363    243 FFEEEPGPVTATLMENF 259
Cdd:TIGR01122 264 IGNGRRGPVTKKLQEAF 280
 
Name Accession Description Interval E-value
PLPDE_IV cd00449
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ...
 29-259 4.53e-76

PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.


Pssm-ID: 238254 [Multi-domain]  Cd Length: 256  Bit Score: 231.72  E-value: 4.53e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   29 AVYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKAG-ADEFKQEVRIKVYLFPDSGEVLFVFSPLNIP 107
Cdd:cd00449   9 GVFEGLRAGKGRLFRLDEHLDRLNRSAKRLGLPIPYDREELREALKELvAANNGASLYIRPLLTRGVGGLGVAPPPSPEP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  108 DL--------------ETGVEVKISNVRRIPDLSTPPALKITGRTDIVLARREIVD--CYDVILLGLNGQVCEGSFSNVF 171
Cdd:cd00449  89 TFvvfaspvgayakggEKGVRLITSPDRRRAAPGGTGDAKTGGNLNSVLAKQEAAEagADEALLLDDNGYVTEGSASNVF 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  172 LVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHSFFEEEPGPV 251
Cdd:cd00449 169 IVKDGELVTPPLDGGILPGITRDSVIELAKELGIKVEERPISLDELYAADEVFLTGTAAEVTPVTEIDGRGIGDGKPGPV 248


                ....*...
gi 4981363  252 TATLMENF 259
Cdd:cd00449 249 TRKLRELL 256
IlvE COG0115
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ...
 1-260 1.65e-73

Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439885 [Multi-domain]  Cd Length: 285  Bit Score: 226.22  E-value: 1.65e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    1 MLIWWRGKFRRADEISLdfSLFEKSLQ-G-AVYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKAGAD 78
Cdd:COG0115   1 RLIWLNGELVPEEEATI--SVLDRGLHyGdGVFEGIRAYDGRLFRLDEHLARLNRSAKRLGIPIPYTEEELLEAIRELVA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   79 EFK-QEVRIKVYLF----------PDSGEVLFVF-SPLNIPD---LETGVEVKISNVRRIPDlSTPPALKITGRTDIVLA 143
Cdd:COG0115  79 ANGlEDGYIRPQVTrgvggrgvfaEEYEPTVIIIaSPLPAYPaeaYEKGVRVITSPYRRAAP-GGLGGIKTGNYLNNVLA 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  144 RREIVD--CYDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEAD 221
Cdd:COG0115 158 KQEAKEagADEALLLDTDGYVAEGSGSNVFIVKDGVLVTPPLSGGILPGITRDSVIELARELGIPVEERPISLEELYTAD 237

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 4981363  222 EMFLTHTSAGVVPVRRLNEHSFFEEEPGPVTATLMENFE 260
Cdd:COG0115 238 EVFLTGTAAEVTPVTEIDGRPIGDGKPGPVTRRLRELYT 276
Aminotran_4 pfam01063
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ...
 29-238 8.75e-56

Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.


Pssm-ID: 395844 [Multi-domain]  Cd Length: 221  Bit Score: 178.71  E-value: 8.75e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363     29 AVYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKAGADEFKQEV-RIKVYLFPDSGEVLFVFSPLNI- 106
Cdd:pfam01063   1 GVFETLRVYNGKIFFLDEHLARLRRSAKLLGIPLPFDEEDLRKIIEELLKANGLGVgRLRLTVSRGPGGFGLPTSDPTLa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    107 -------PDLETGVEVKISNVRRIPDLSTPPALKITGRTDIVLARREIV--DCYDVILLGLNGQVCEGSFSNVFLVKEGK 177
Cdd:pfam01063  81 ifvsalpPPPESKKKGVISSLVRRNPPSPLPGAKTLNYLENVLARREAKaqGADDALLLDEDGNVTEGSTSNVFLVKGGT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4981363    178 LITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRL 238
Cdd:pfam01063 161 LYTPPLESGILPGITRQALLDLAKALGLEVEERPITLADLQEADEAFLTNSLRGVTPVSSI 221
D-AAT_like cd01558
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ...
 4-259 1.31e-49

D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.


Pssm-ID: 238799 [Multi-domain]  Cd Length: 270  Bit Score: 164.69  E-value: 1.31e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    4 WWRGKFRRADEISLdfSLFEKSLQGA--VYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKAGADEFK 81
Cdd:cd01558   1 YLNGEYVPREEAKV--SVFDRGFLFGdgVYEVIRVYNGKPFALDEHLDRLYRSAKELRIDIPYTREELKELIRELVAKNE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   82 QEVRIkVYL------------FPDSGE-VLFVF----SPLNIPDLETGVEVKISNVRRIPDlstpPALKITGRTDIVLAR 144
Cdd:cd01558  79 GGEGD-VYIqvtrgvgprghdFPKCVKpTVVIItqplPLPPAELLEKGVRVITVPDIRWLR----CDIKSLNLLNNVLAK 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  145 REIVD--CYDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADE 222
Cdd:cd01558 154 QEAKEagADEAILLDADGLVTEGSSSNVFIVKNGVLVTPPLDNGILPGITRATVIELAKELGIPVEERPFSLEELYTADE 233

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 4981363  223 MFLTHTSAGVVPVRRLNEHSFFEEEPGPVTATLMENF 259
Cdd:cd01558 234 VFLTSTTAEVMPVVEIDGRPIGDGKPGPVTKRLREAY 270
PRK06606 PRK06606
branched-chain amino acid transaminase;
29-259 8.97e-46

branched-chain amino acid transaminase;


Pssm-ID: 235841  Cd Length: 306  Bit Score: 155.69  E-value: 8.97e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    29 AVYETLRTY----SRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKagadEFKQEVRIK-VYLFPdsgevlFVF-- 101
Cdd:PRK06606  35 GVFEGIRAYdtpkGPAIFRLREHTKRLFNSAKILRMEIPYSVDELMEAQR----EVVRKNNLKsAYIRP------LVFvg 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   102 ------SPLNIPD-----------------LETGVEVKISNVRRIPDLSTPPALKITGR-TDIVLARREIVDC-YD-VIL 155
Cdd:PRK06606 105 deglgvRPHGLPTdvaiaawpwgaylgeeaLEKGIRVKVSSWTRHAPNSIPTRAKASGNyLNSILAKTEARRNgYDeALL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   156 LGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPV 235
Cdd:PRK06606 185 LDVEGYVSEGSGENIFIVRDGVLYTPPLTSSILEGITRDTVITLAKDLGIEVIERRITRDELYIADEVFFTGTAAEVTPI 264

                        250       260
                 ....*....|....*....|....
gi 4981363   236 RRLNEHSFFEEEPGPVTATLMENF 259
Cdd:PRK06606 265 REVDGRQIGNGKRGPITEKLQSAY 288
ADCL_like cd01559
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ...
 29-259 1.11e-41

ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.


Pssm-ID: 238800 [Multi-domain]  Cd Length: 249  Bit Score: 143.60  E-value: 1.11e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   29 AVYETLRTYSRAPFAAYKHYTRLKRSADffnlplSLSFDEFTK-VLKAGADEFKQ-----EVRIKVYL--------FPDS 94
Cdd:cd01559   9 GVFETMRALDGRLFLLDAHLARLERSAR------RLGIPEPDLpRLRAALESLLAandidEGRIRLILsrgpggrgYAPS 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   95 GE----VLFVFSPLNIPDLETGVEVKISNVRripdLSTPPAL---KITGRTDIVLARREIVD--CYDVILLGLNGQVCEG 165
Cdd:cd01559  83 VCpgpaLYVSVIPLPPAWRQDGVRLITCPVR----LGEQPLLaglKHLNYLENVLAKREARDrgADEALFLDTDGRVIEG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  166 SFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHSFfe 245
Cdd:cd01559 159 TASNLFFVKDGELVTPSLDRGGLAGITRQRVIELAAAKGYAVDERPLRLEDLLAADEAFLTNSLLGVAPVTAIDDHDG-- 236

                       250
                ....*....|....
gi 4981363  246 eEPGPVTATLMENF 259
Cdd:cd01559 237 -PPGPLTRALRELL 249
ilvE_I TIGR01122
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ...
 29-259 2.88e-39

branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 130192  Cd Length: 298  Bit Score: 138.65  E-value: 2.88e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363     29 AVYETLRTY----SRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKA------------------GADEFKqeVRI 86
Cdd:TIGR01122  26 GVFEGIRAYdtdkGPAIFRLKEHIQRLYDSAKIYRMEIPYSKEELMEATREtlrknnlrsayirplvfrGDGDLG--LNP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363     87 KVYLFPDSGEVLFVFSP-LNIPDLETGVEVKISNVRRIPDLSTPPALKITGR-TDIVLARREIVDC-YD-VILLGLNGQV 162
Cdd:TIGR01122 104 RAGYKPDVIIAAWPWGAyLGEEALEKGIDAKVSSWRRNAPNTIPTAAKAGGNyLNSLLAKSEARRHgYDeAILLDVEGYV 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    163 CEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHS 242
Cdd:TIGR01122 184 AEGSGENIFIVKDGVLFTPPVTSSILPGITRDTVITLAKELGIEVVEQPISREELYTADEAFFTGTAAEITPIREVDGRK 263

                         250
                  ....*....|....*..
gi 4981363    243 FFEEEPGPVTATLMENF 259
Cdd:TIGR01122 264 IGNGRRGPVTKKLQEAF 280
BCAT_beta_family cd01557
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ...
 29-252 3.01e-37

BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.


Pssm-ID: 238798  Cd Length: 279  Bit Score: 132.70  E-value: 3.01e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   29 AVYETLRTYSRAP-----FAAYKHYTRLKRSADFFNLPlSLSFDEF----TKVLKAGADEFKQEVRIKVYLFP---DSGE 96
Cdd:cd01557  14 AVFEGLKAYRTPDgkivlFRPDENAERLNRSARRLGLP-PFSVEEFidaiKELVKLDADWVPYGGGASLYIRPfifGTDP 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   97 VLFVFSPLNI-------------PDLETGVEVKISNVRRIPDlSTPPALKITGR-TDIVLARREIVD--CYDVILL-GLN 159
Cdd:cd01557  93 QLGVSPALEYlfavfaspvgayfKGGEKGVSALVSSFRRAAP-GGPGAAKAGGNyAASLLAQKEAAEkgYDQALWLdGAH 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363  160 GQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLN 239
Cdd:cd01557 172 GYVAEVGTMNIFFVKDGELITPPLDGSILPGITRDSILELARDLGIKVEERPITRDELYEADEVFATGTAAVVTPVGEID 251

                       250
                ....*....|....*
gi 4981363  240 EHS--FFEEEPGPVT 252
Cdd:cd01557 252 YRGkePGEGEVGPVT 266
PRK07650 PRK07650
4-amino-4-deoxychorismate lyase; Provisional
 30-266 8.72e-36

4-amino-4-deoxychorismate lyase; Provisional


Pssm-ID: 181067  Cd Length: 283  Bit Score: 128.93  E-value: 8.72e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    30 VYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKA--GADEFKQE-VRIKVY-------LFPDSGE--V 97
Cdd:PRK07650  29 VFETFRIYNGHPFLLDDHYDRLNDALDTLQIEWTMTKDEVLLILKNllEKNGLENAyVRFNVSagigeigLQTEMYEepT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    98 LFVF-SPLNIPDLETGVEVKISNVRRipdlSTPPA---LKITGRTDIVLARREIVDCYDV--ILLGLNGQVCEGSFSNVF 171
Cdd:PRK07650 109 VIVYmKPLAPPGLPAEKEGVVLKQRR----NTPEGafrLKSHHYLNNILGKREIGNDPNKegIFLTEEGYVAEGIVSNLF 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   172 LVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHSFFEEEpGPV 251
Cdd:PRK07650 185 WVKGDIVYTPSLETGILNGITRAFVIKVLEELGIEVKEGFYTKEELLSADEVFVTNSIQEIVPLTRIEERDFPGKV-GMV 263

                        250
                 ....*....|....*
gi 4981363   252 TATLMENFEPFVLNL 266
Cdd:PRK07650 264 TKRLQNLYEMQREKL 278
PRK08320 PRK08320
branched-chain amino acid aminotransferase; Reviewed
 30-263 1.31e-35

branched-chain amino acid aminotransferase; Reviewed


Pssm-ID: 236238 [Multi-domain]  Cd Length: 288  Bit Score: 128.84  E-value: 1.31e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    30 VYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKagadefkQEVRIK----VYLFP-------DSG--- 95
Cdd:PRK08320  32 VFEGIRAYNGRVFRLKEHIDRLYDSAKAIMLEIPLSKEEMTEIVL-------ETLRKNnlrdAYIRLvvsrgvgDLGldp 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    96 ------EVLFVFSPLNI--PDL-ETGVEVKISNVRRIPDLSTPPALKITGRTDIVLARRE--IVDCYDVILLGLNGQVCE 164
Cdd:PRK08320 105 rkcpkpTVVCIAEPIGLypGELyEKGLKVITVSTRRNRPDALSPQVKSLNYLNNILAKIEanLAGVDEAIMLNDEGYVAE 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   165 GSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHSFF 244
Cdd:PRK08320 185 GTGDNIFIVKNGKLITPPTYAGALEGITRNAVIEIAKELGIPVREELFTLHDLYTADEVFLTGTAAEVIPVVKVDGRVIG 264

                        250
                 ....*....|....*....
gi 4981363   245 EEEPGPVTATLMENFEPFV 263
Cdd:PRK08320 265 DGKPGPITKKLLEEFRELT 283
PRK06680 PRK06680
D-amino acid aminotransferase; Reviewed
 7-262 3.34e-28

D-amino acid aminotransferase; Reviewed


Pssm-ID: 180656 [Multi-domain]  Cd Length: 286  Bit Score: 109.25  E-value: 3.34e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363     7 GKFRRADEISLdfSLFEKSLQGA--VYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKagadEFKQEV 84
Cdd:PRK06680   9 GRYVNHREARV--HIEDRGFQFAdgIYEVCAVRDGKLVDLDRHLARLFRSLGEIRIAPPMTRAELVEVLR----ELIRRN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    85 RIK---VYL------------FPDSG--EVLFVFS-----PLNIPDLETGVEVKIsnvrrIPDLSTPpalkitgRTDI-- 140
Cdd:PRK06680  83 RVReglVYLqvtrgvarrdhvFPAADvkPSVVVFAksvdfARPAAAAETGIKVIT-----VPDNRWK-------RCDIks 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   141 ------VLARREIVD--CYDVILLGlNGQVCEGSFSNVFLV-KEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERV 211
Cdd:PRK06680 151 vgllpnVLAKQAAKEagAQEAWMVD-DGFVTEGASSNAWIVtKDGKLVTRPADNFILPGITRHTLIDLAKELGLEVEERP 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 4981363   212 VWVWELFEADEMFLTHTSAGVVPVRRLNEHSFFEEEPGPVTATLMENFEPF 262
Cdd:PRK06680 230 FTLQEAYAAREAFITAASSFVFPVVQIDGKQIGNGKPGPIAKRLREAYEEF 280
PRK07544 PRK07544
branched-chain amino acid aminotransferase; Validated
 3-263 7.69e-28

branched-chain amino acid aminotransferase; Validated


Pssm-ID: 181025  Cd Length: 292  Bit Score: 108.14  E-value: 7.69e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363     3 IWWRGKF---RRADEISLDFSLFEKSlqgAVYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFtkvlkagaDE 79
Cdd:PRK07544  11 IWMDGELvpwRDAKVHVLTHGLHYAS---SVFEGERAYGGKIFKLREHSERLRRSAELLDFEIPYSVAEI--------DA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    80 FKQEVrIKVYLFPDS---------GEVLFVFSPLNIP-------------DLET---GVEVKISNVRRiPDLSTPP-ALK 133
Cdd:PRK07544  80 AKKET-LAANGLTDAyvrpvawrgSEMMGVSAQQNKIhlaiaawewpsyfDPEAkmkGIRLDIAKWRR-PDPETAPsAAK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   134 ITGRTDIVLA---RREIVDCYDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLDSgILDGITRENVIKLAKSLEIPVEER 210
Cdd:PRK07544 158 AAGLYMICTIskhAAEAKGYADALMLDYRGYVAEATGANIFFVKDGVIHTPTPDC-FLDGITRQTVIELAKRRGIEVVER 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4981363   211 VVWVWELFEADEMFLTHTSAGVVPVRRLNEHSFfeeEPGPVTATLMENFEPFV 263
Cdd:PRK07544 237 HIMPEELAGFSECFLTGTAAEVTPVSEIGEYRF---TPGAITRDLMDDYEALV 286
PRK12479 PRK12479
branched-chain-amino-acid transaminase;
30-260 2.11e-27

branched-chain-amino-acid transaminase;


Pssm-ID: 183549 [Multi-domain]  Cd Length: 299  Bit Score: 107.35  E-value: 2.11e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    30 VYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTK-----VLKAG-ADEFkqeVRIKVY-------LFPDSGE 96
Cdd:PRK12479  33 VFEGIRSYGGNVFCLKEHVKRLYESAKSILLTIPLTVDEMEEavlqtLQKNEyADAY---IRLIVSrgkgdlgLDPRSCV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    97 ---VLFVFSPLNIPDLE---TGVEV-KISNVRRIPDlSTPPALKITGRTDIVLARREIVDC--YDVILLGLNGQVCEGSF 167
Cdd:PRK12479 110 kpsVIIIAEQLKLFPQEfydNGLSVvSVASRRNTPD-ALDPRIKSMNYLNNVLVKIEAAQAgvLEALMLNQQGYVCEGSG 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   168 SNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHSFFEEE 247
Cdd:PRK12479 189 DNVFVVKDGKVLTPPSYLGALEGITRNSVIELCERLSIPCEERPFTRHDVYVADEVFLTGTAAELIPVVKVDSREIGDGK 268

                        250
                 ....*....|...
gi 4981363   248 PGPVTATLMENFE 260
Cdd:PRK12479 269 PGSVTKQLTEEFK 281
PRK06092 PRK06092
4-amino-4-deoxychorismate lyase; Reviewed
 110-260 8.77e-24

4-amino-4-deoxychorismate lyase; Reviewed


Pssm-ID: 235696  Cd Length: 268  Bit Score: 96.83  E-value: 8.77e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   110 ETGVEVKISNVRripdLSTPPAL---KITGRTDIVLARREIVDC--YDVILLGLNGQVCEGSFSNVFLVKEGKLITPSLD 184
Cdd:PRK06092 118 EQGITLALCPTR----LGRNPLLagiKHLNRLEQVLIRAELEQTeaDEALVLDSEGWVIECCAANLFWRKGGVVYTPDLD 193

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4981363   185 -SGIlDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEHSFfeeEPGPVTATLMENFE 260
Cdd:PRK06092 194 qCGV-AGVMRQFILELLAQSGYPVVEVDASLEELLQADEVFICNSLMPVWPVRAIGETSY---SSGTLTRYLQPLCE 266
PRK12400 PRK12400
D-amino acid aminotransferase; Reviewed
 21-259 3.39e-21

D-amino acid aminotransferase; Reviewed


Pssm-ID: 171470  Cd Length: 290  Bit Score: 90.46  E-value: 3.39e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    21 LFEKSLQ--GAVYETLRTYSRAPFAAYKHYTRLKRSADFFNLPLSLSFDEFTKVLKA--GADEFKQEVRIKVYLFPDSGE 96
Cdd:PRK12400  25 LEERGLQfgDGVYEVIRLYKGNFHLLDPHITRLYRSMEEIELTLPFSKAELITLLYKliENNNFHEDGTIYLQVSRGVQA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    97 VLFVFSPlnipDLETGVEVKISNVRR--------IPDLSTPPALKItgRTDI--------VLA--RREIVDCYDVILLgL 158
Cdd:PRK12400 105 RTHTFSY----DVPPTIYAYITKKERpalwieygVRAISEPDTRWL--RCDIkslnllpnILAatKAERKGCKEALFV-R 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   159 NGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRL 238
Cdd:PRK12400 178 NGTVTEGSHSNFFLIKNGTLYTHPANHLILNGIIRQYVLSLAKTLRIPVQEELFSVRDVYQADECFFTGTTIEILPMTHL 257

                        250       260
                 ....*....|....*....|.
gi 4981363   239 NEHSFFEEEPGPVTATLMENF 259
Cdd:PRK12400 258 DGTAIQDGQVGPITKMLQRSF 278
PRK13356 PRK13356
branched-chain amino acid aminotransferase;
154-253 1.36e-16

branched-chain amino acid aminotransferase;


Pssm-ID: 237362  Cd Length: 286  Bit Score: 77.69  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   154 ILLGLNGQVCEGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVV 233
Cdd:PRK13356 176 LVLDMLGNVAETATSNVFMVKDGVVFTPVPNGTFLNGITRQRVIALLREDGVTVVETTLTYEDFLEADEVFSTGNYSKVV 255

                         90       100
                 ....*....|....*....|
gi 4981363   234 PVRRLNEHSFfeeEPGPVTA 253
Cdd:PRK13356 256 PVTRFDDRSL---QPGPVTR 272
PRK13357 PRK13357
branched-chain amino acid aminotransferase; Provisional
 169-255 1.65e-16

branched-chain amino acid aminotransferase; Provisional


Pssm-ID: 237363  Cd Length: 356  Bit Score: 78.27  E-value: 1.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   169 NVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEA------DEMFLTHTSAGVVPVRRL---- 238
Cdd:PRK13357 237 NFFFITKDGTVTPPLSGSILPGITRDSLLQLAEDLGLTVEERPVSIDEWQADaasgefTEAFACGTAAVITPIGGIkykd 316

                         90
                 ....*....|....*..
gi 4981363   239 NEHSFFEEEPGPVTATL 255
Cdd:PRK13357 317 KEFVIGDGEVGPVTQKL 333
PRK07849 PRK07849
aminodeoxychorismate lyase;
30-241 1.81e-16

aminodeoxychorismate lyase;


Pssm-ID: 236114 [Multi-domain]  Cd Length: 292  Bit Score: 77.31  E-value: 1.81e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363    30 VYETLRTYSRAPFAAYKHYTRLKRSADFFNLPlSLSFDEFTKVLKAGADEFKQE-----VRIkVY---LFPDSGEVLFVF 101
Cdd:PRK07849  41 VFETLLVRDGRPCNLEAHLERLARSAALLDLP-EPDLDRWRRAVELAIEEWRAPedeaaLRL-VYsrgRESGGAPTAWVT 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   102 -SPLNIPDL---ETGVEVkISNVRRIP-DLSTP-PALKITGRTdivL-----------ARREIVDcyDVILLGLNGQVCE 164
Cdd:PRK07849 119 vSPVPERVArarREGVSV-ITLDRGYPsDAAERaPWLLAGAKT---LsyavnmaalryAARRGAD--DVIFTSTDGYVLE 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4981363   165 GSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEH 241
Cdd:PRK07849 193 GPTSTVVIATDDRLLTPPPWYGILPGTTQAALFEVAREKGWDCEYRALRPADLFAADGVWLVSSVRLAARVHTLDGR 269
PLN02782 PLN02782
Branched-chain amino acid aminotransferase
 164-272 1.60e-13

Branched-chain amino acid aminotransferase


Pssm-ID: 215418  Cd Length: 403  Bit Score: 69.88  E-value: 1.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   164 EGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPV-------R 236
Cdd:PLN02782 285 EVSSCNIFIVKDNVISTPAIKGTILPGITRKSIIDVARSQGFQVEERNVTVDELLEADEVFCTGTAVVVSPVgsitykgK 364

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 4981363   237 RLnehSFFEEEPGPVTATLMENFEPFVLNLEENWVG 272
Cdd:PLN02782 365 RV---SYGEGGFGTVSQQLYTVLTSLQMGLIEDNMN 397
PLN02883 PLN02883
Branched-chain amino acid aminotransferase
 164-235 1.52e-12

Branched-chain amino acid aminotransferase


Pssm-ID: 178471  Cd Length: 384  Bit Score: 66.66  E-value: 1.52e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4981363   164 EGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPV 235
Cdd:PLN02883 267 EVSAANIFLVKGNIIVTPATSGTILGGITRKSIIEIALDLGYKVEERRVPVEELKEAEEVFCTGTAAGVASV 338
PRK07546 PRK07546
hypothetical protein; Provisional
 152-236 4.81e-10

hypothetical protein; Provisional


Pssm-ID: 169002 [Multi-domain]  Cd Length: 209  Bit Score: 58.07  E-value: 4.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   152 DVILLGLNGQVCEGSFSNVFL-VKEGKLITPSLDSGILDGITRENVIKLAKsleipVEERVVWVWELFEADEMFLTHTSA 230
Cdd:PRK07546 127 EVILLNERGEVCEGTITNVFLdRGGGMLTTPPLSCGLLPGVLRAELLDAGR-----AREAVLTVDDLKSARAIWVGNSLR 201


                 ....*.
gi 4981363   231 GVVPVR 236
Cdd:PRK07546 202 GLIRAE 207
PLN02259 PLN02259
branched-chain-amino-acid aminotransferase 2
 164-235 1.73e-09

branched-chain-amino-acid aminotransferase 2


Pssm-ID: 177901  Cd Length: 388  Bit Score: 57.81  E-value: 1.73e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4981363   164 EGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPV 235
Cdd:PLN02259 271 EASSCNVFVVKGRTISTPATNGTILEGITRKSVMEIASDQGYQVVEKAVHVDEVMDADEVFCTGTAVVVAPV 342
PLN03117 PLN03117
Branched-chain-amino-acid aminotransferase; Provisional
 164-241 2.36e-09

Branched-chain-amino-acid aminotransferase; Provisional


Pssm-ID: 178664  Cd Length: 355  Bit Score: 57.25  E-value: 2.36e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4981363   164 EGSFSNVFLVKEGKLITPSLDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEADEMFLTHTSAGVVPVRRLNEH 241
Cdd:PLN03117 234 ELSACNIFILKGNIVSTPPTSGTILPGVTRKSISELARDIGYQVEERDVSVDELLEAEEVFCTGTAVVVKAVETVTFH 311
PLN02845 PLN02845
Branched-chain-amino-acid aminotransferase-like protein
 159-257 2.40e-08

Branched-chain-amino-acid aminotransferase-like protein


Pssm-ID: 215454 [Multi-domain]  Cd Length: 336  Bit Score: 53.87  E-value: 2.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   159 NGQVCEGSFSNV-FLVKEGKLITPSLDSgILDGITRENVIKLAKSLEIP-----VEERVVWVWELFEADEMFLTHTSAGV 232
Cdd:PLN02845 213 EGFVAEGPNMNVaFLTNDGELVLPPFDK-ILSGCTARRVLELAPRLVSPgdlrgVKQRKISVEEAKAADEMMLIGSGVPV 291

                         90       100
                 ....*....|....*....|....*
gi 4981363   233 VPVRRLNEHSFFEEEPGPVTATLME 257
Cdd:PLN02845 292 LPIVSWDGQPIGDGKVGPITLALHD 316
PRK09266 PRK09266
hypothetical protein; Provisional
 142-248 1.89e-05

hypothetical protein; Provisional


Pssm-ID: 236438  Cd Length: 266  Bit Score: 44.97  E-value: 1.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4981363   142 LARREIVDcyDVILLGLNGQVCEGSFSNVFLVKEGKLITPslDSGILDGITRENVIKLAKSLEIPVEERVVWVWELFEAD 221
Cdd:PRK09266 147 LAQRAGFD--DALFVDPDGRVSEGATWNLGFWDGGAVVWP--QAPALPGVTMALLQRGLERLGIPQRTRPVTLADLGRFA 222

                         90       100
                 ....*....|....*....|....*..
gi 4981363   222 EMFLTHTSAGVVPVRRLNEHSFFEEEP 248
Cdd:PRK09266 223 GAFACNAWRGQRAVSAIDDVALPDSHA 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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