NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|5911298|gb|AAD55741|]
View 

BcDNA.LD28120 [Drosophila melanogaster]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 44-221 7.93e-59

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17352:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 361  Bit Score: 201.63  E-value: 7.93e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17352   1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:cd17352  81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160

                       170
                ....*....|....*...
gi 5911298  204 LIYAGIAMNAILCALTLQ 221
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR 178
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 459-626 2.40e-37

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17352:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 361  Bit Score: 142.69  E-value: 2.40e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  459 LLRDFTFVNLAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEK--VKLDNRVLFAFG 536
Cdd:cd17352 179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  537 ILCIAVGRVVVAFTdsYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAY 616
Cdd:cd17352 259 ILGLSLLAFPLATT--YVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYT 336

                       170
                ....*....|.
gi 5911298  617 G-YAATIHTIN 626
Cdd:cd17352 337 GdYDAAFYFCG 347
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 44-221 7.93e-59

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 201.63  E-value: 7.93e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17352   1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:cd17352  81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160

                       170
                ....*....|....*...
gi 5911298  204 LIYAGIAMNAILCALTLQ 221
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR 178
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 459-626 2.40e-37

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 142.69  E-value: 2.40e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  459 LLRDFTFVNLAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEK--VKLDNRVLFAFG 536
Cdd:cd17352 179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  537 ILCIAVGRVVVAFTdsYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAY 616
Cdd:cd17352 259 ILGLSLLAFPLATT--YVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYT 336

                       170
                ....*....|.
gi 5911298  617 G-YAATIHTIN 626
Cdd:cd17352 337 GdYDAAFYFCG 347
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 34-223 3.76e-16

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 81.33  E-value: 3.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298     34 PDFVAPDGGWGWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQV 113
Cdd:TIGR00892   7 PEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    114 ALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVL 193
Cdd:TIGR00892  87 VIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYL 166

                         170       180       190
                  ....*....|....*....|....*....|
gi 5911298    194 LGYYGAQGTILIYAGIAMNAILCALTLQPV 223
Cdd:TIGR00892 167 FESFGWRGSFLILGGLLLHCCVCGALMRPV 196
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
45-220 5.14e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 77.23  E-value: 5.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLG 124
Cdd:COG2223   4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  125 VFLSAFCTTFWQYIIcLSAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:COG2223  84 LLLLALAVSYWLLLL-LGLLLGIGGGGSFAVGIALVSKWFPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162

                       170
                ....*....|....*..
gi 5911298  204 LIYAGIAMNAILCALTL 220
Cdd:COG2223 163 LILGILLLVVAVLAWLF 179
MFS_1 pfam07690
Major Facilitator Superfamily;
45-233 1.65e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.07  E-value: 1.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298     45 WVVCLAAGLNNFFLFPALQQYgliyrvRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLG 124
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLL------LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    125 VFLSAFCTTFWQYIIcLSAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:pfam07690  76 LLLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPEERgRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 5911298    204 LIYAGIAMNAILCALTLQPVLWHVKKPEKP 233
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAE 184
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
461-621 2.16e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.77  E-value: 2.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  461 RDFTFVNLAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSL-LACMDISVRFLAPLALekvKLDNRVLFAFGILC 539
Cdd:COG2814   8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAyLLGAALGAPLAGRLAD---RFGRRRVLLLGLLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  540 IAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIfSFAMGPILG-ILTEAYGY 618
Cdd:COG2814  85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGL-GPALGPLLGgLLADLFGW 163


                ...
gi 5911298  619 AAT 621
Cdd:COG2814 164 RWV 166
MFS_1 pfam07690
Major Facilitator Superfamily;
433-607 4.19e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.42  E-value: 4.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    433 DNTEAEEEAKRRMTFFQKVSKFFDLDLLRDFTFVNLAVGMSIMMFGemnFSVLTPFILNSFGYTDTQISLVMSLLACMDI 512
Cdd:pfam07690 173 PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG---LLTYLPLYQEVLGLSALLAGLLLGLGGLLGA 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    513 SVRFLAPLALEKVKLDNRVLFA-FGILCIAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAAS 591
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLAlLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329

                         170
                  ....*....|....*.
gi 5911298    592 GLQLIFNTIfSFAMGP 607
Cdd:pfam07690 330 GLYNTAGSL-GGALGP 344
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 470-570 1.04e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 41.98  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    470 VGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVklDNRVLFAFGILCIAVGRVVVAF 549
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRS--NPRVFLPIGLILCAIVNLFFGF 79

                          90       100
                  ....*....|....*....|.
gi 5911298    550 TDSYEIMIGVFLLIGFGKAFR 570
Cdd:TIGR00881  80 STSLWVMAALWALNGIFQGMG 100
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 44-221 7.93e-59

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 201.63  E-value: 7.93e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17352   1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:cd17352  81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160

                       170
                ....*....|....*...
gi 5911298  204 LIYAGIAMNAILCALTLQ 221
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR 178
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 459-626 2.40e-37

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 142.69  E-value: 2.40e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  459 LLRDFTFVNLAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEK--VKLDNRVLFAFG 536
Cdd:cd17352 179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLL 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  537 ILCIAVGRVVVAFTdsYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAY 616
Cdd:cd17352 259 ILGLSLLAFPLATT--YVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYT 336

                       170
                ....*....|.
gi 5911298  617 G-YAATIHTIN 626
Cdd:cd17352 337 GdYDAAFYFCG 347
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 44-223 2.31e-18

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 87.45  E-value: 2.31e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17423   1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:cd17423  81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160

                       170       180
                ....*....|....*....|
gi 5911298  204 LIYAGIAMNAILCALTLQPV 223
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPL 180
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 34-223 3.76e-16

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 81.33  E-value: 3.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298     34 PDFVAPDGGWGWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQV 113
Cdd:TIGR00892   7 PEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    114 ALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVL 193
Cdd:TIGR00892  87 VIAGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYL 166

                         170       180       190
                  ....*....|....*....|....*....|
gi 5911298    194 LGYYGAQGTILIYAGIAMNAILCALTLQPV 223
Cdd:TIGR00892 167 FESFGWRGSFLILGGLLLHCCVCGALMRPV 196
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
45-220 5.14e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 77.23  E-value: 5.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLG 124
Cdd:COG2223   4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  125 VFLSAFCTTFWQYIIcLSAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:COG2223  84 LLLLALAVSYWLLLL-LGLLLGIGGGGSFAVGIALVSKWFPPDRRgLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162

                       170
                ....*....|....*..
gi 5911298  204 LIYAGIAMNAILCALTL 220
Cdd:COG2223 163 LILGILLLVVAVLAWLF 179
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
45-233 6.80e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 76.55  E-value: 6.80e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALQQYgliyrvrMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLG 124
Cdd:COG2814  16 ALGAFLSGLGIGIVLPALPLI-------AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  125 VFLSAFCTTFWQYIIcLSAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:COG2814  89 SLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVPPERRgRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                       170       180       190
                ....*....|....*....|....*....|
gi 5911298  204 LIYAGIAMNAILCALTLQPVLWHVKKPEKP 233
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARARLR 197
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
41-211 1.10e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 76.06  E-value: 1.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   41 GGWGWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSL 120
Cdd:COG2271   5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  121 AFLGVFLSAFCTTFWQYIICLsAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGA 199
Cdd:COG2271  85 WGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPPKERgRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163

                       170
                ....*....|..
gi 5911298  200 QGTILIYAGIAM 211
Cdd:COG2271 164 RAAFLILGLPGL 175
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 44-224 2.25e-14

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 75.39  E-value: 2.25e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17355   1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLG-LAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGT 202
Cdd:cd17355  81 GLVLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160

                       170       180
                ....*....|....*....|..
gi 5911298  203 ILIYagiamnAILCALTLQPVL 224
Cdd:cd17355 161 LLVL------ALLALLVLVPVL 176
MFS_1 pfam07690
Major Facilitator Superfamily;
45-233 1.65e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 72.07  E-value: 1.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298     45 WVVCLAAGLNNFFLFPALQQYgliyrvRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLG 124
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLL------LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    125 VFLSAFCTTFWQYIIcLSAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:pfam07690  76 LLLLLFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPEERgRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 5911298    204 LIYAGIAMNAILCALTLQPVLWHVKKPEKP 233
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAE 184
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
 44-223 1.14e-11

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 66.68  E-value: 1.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17430   1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSwtiTGLGPIFFPQVS---TVLLGYYGAQ 200
Cdd:cd17430  81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLA---AAGSPVFLSALSplgQILLEEYGWR 157

                       170       180
                ....*....|....*....|...
gi 5911298  201 GTILIYAGIAMNAILCALTLQPV 223
Cdd:cd17430 158 GGFLILGGLLLNCCTCGAVMRPL 180
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
461-621 2.16e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.77  E-value: 2.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  461 RDFTFVNLAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSL-LACMDISVRFLAPLALekvKLDNRVLFAFGILC 539
Cdd:COG2814   8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAyLLGAALGAPLAGRLAD---RFGRRRVLLLGLLL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  540 IAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIfSFAMGPILG-ILTEAYGY 618
Cdd:COG2814  85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGL-GPALGPLLGgLLADLFGW 163


                ...
gi 5911298  619 AAT 621
Cdd:COG2814 164 RWV 166
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
 44-232 4.94e-11

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 65.24  E-value: 4.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAK-----QTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGT 118
Cdd:cd17420   1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKLGDpeasfKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  119 SLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYG 198
Cdd:cd17420  81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160

                       170       180       190
                ....*....|....*....|....*....|....
gi 5911298  199 AQGTILIYAGIAMNAILCALTLQPVLWHVKKPEK 232
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKS 194
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
463-622 4.96e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 64.89  E-value: 4.96e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  463 FTFVNLAVGMSIMMFgemnFSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVKLDNRVLFAFGILCIAV 542
Cdd:COG2271 185 LALAYFLVYFALYGF----LTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  543 GRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAYGYAATI 622
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
41-233 1.42e-10

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 63.74  E-value: 1.42e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   41 GGWGWVVCL-AAGLNnffLFPALQQYGLIYRVRMQSLGFDAKQT---TTIVNVVMAISSLVGivnGAMFRRFTFRQVALT 116
Cdd:COG2807  15 GRWLLLLAIvLVALN---LRPAITSVGPLLPEIRADLGLSATQAgllTTLPLLAFGLFAPLA---PRLARRFGLERTLLL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  117 GTSLAFLGVFLSAFCTTFWQYIIcLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGY 196
Cdd:COG2807  89 ALLLLAAGLLLRSLAPSVALLLA-GTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA 167

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 5911298  197 YGAQGTILIYAGIAMNAILCALtlqPVLWHVKKPEKP 233
Cdd:COG2807 168 LGWRGALAVWALLALLALLLWL---PLLRRRPAAAAA 201
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
45-222 1.37e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 60.27  E-value: 1.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFpALQQYGLIYRVrmQSLGFDAKQT---TTIVNVVMAISSLV-GIVNGAMFRRFtfRQVALTGTSL 120
Cdd:COG2271 183 WLLALAYFLVYFALY-GFLTWLPTYLV--EVRGLSLAQAgllLSLPFLAGIVGSLLgGWLSDRLGRRR--KLVLAIGLLL 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  121 AFLGVFLSAFCTTFWQYIICLsAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGA 199
Cdd:COG2271 258 AALALLLLALLPSPALAIALL-FLAGFGLGGAFGLLWALAAELFPKKARgTASGLVNTFGFLGGALGPLLVGYLLDATGY 336

                       170       180
                ....*....|....*....|...
gi 5911298  200 QGTILIYAGIAMNAILCALTLQP 222
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLR 359
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
457-602 2.73e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.22  E-value: 2.73e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  457 LDLLRDFTFVNLAVGMSIMMFGEMNFSVLTPFIL-NSFGYTDTQISLVMSLLACMDISVRFLAPLALEKvkLDNRVLFAF 535
Cdd:COG2814 201 RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR--FGRRRLLLI 278

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5911298  536 GILCIAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFS 602
Cdd:COG2814 279 GLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 45-252 3.36e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 59.36  E-value: 3.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALQQYgliyrvrMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLG 124
Cdd:cd06174   2 LLGFFLTGLARGLISPLLPAL-------LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  125 VFLSAFCTTFWQYIICLsAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIffpqVSTVLLGYYGAQGTI 203
Cdd:cd06174  75 ALLFAFAPSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPERERgRALGLLQAFGSVGGI----LGPLLGGILASSLGF 149

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 5911298  204 LIYAGIAMNAILCALTLqpVLWHVKKPEKPVHNTIEGIAETEKLQPELL 252
Cdd:cd06174 150 GWRAVFLIAAALALLAA--ILLLLVVPDPPESARAKNEEASSKSVLKLL 196
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
 44-216 4.84e-09

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 58.69  E-value: 4.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17429   1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFpqvsTVLLGY----YGA 199
Cdd:cd17429  81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLM----TILLKYlcaeFGW 156

                       170
                ....*....|....*..
gi 5911298  200 QGTILIYAGIAMNAILC 216
Cdd:cd17429 157 RNAMFIQGAVSLNLCVC 173
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
 44-223 5.87e-09

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 58.30  E-value: 5.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17421   1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFklKRRRATGFSWTITGLGPIF-FPQVSTVLLGYYGAQGT 202
Cdd:cd17421  81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYF--KKRLATAYAIARSGMGLTFaLAPFTQLLLDEYDWQGA 158

                       170       180
                ....*....|....*....|.
gi 5911298  203 ILIYAGIAMNAILCALTLQPV 223
Cdd:cd17421 159 LLIFGGIMLNLVASGMLLRPI 179
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 464-620 6.76e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 57.99  E-value: 6.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  464 TFVNLAVGMSIMMFgemnFSVLTPFILNsFGYTDTQISLVMSLLACMDISVRFLAPLALEKvkLDNRVLFAFGILCIAVG 543
Cdd:cd17489   2 LLANFFFFLSFYLL----LPVLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDR--FGRKRLLLIGLLIFALA 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5911298  544 RVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIfSFAMGPILGI-LTEAYGYAA 620
Cdd:cd17489  75 TLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTL-AMALGPALGLfLYQHLGFAV 151
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 45-225 9.03e-09

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 57.13  E-value: 9.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLG 124
Cdd:COG0477  13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  125 VFLSAFCTTFWQyIICLSAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:COG0477  93 SLLCGLAPSPEL-LIAARALQGIGAGGLMPGALALIAELFPARERgRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171

                       170       180
                ....*....|....*....|..
gi 5911298  204 LIYAGIAMNAILCALTLQPVLW 225
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRG 193
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 454-600 9.75e-09

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 57.59  E-value: 9.75e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  454 FFDLDLLRDFTFVNLAVGMSIMMFGEMNFSVLTP-FILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVklDNRVL 532
Cdd:cd17503 169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPlYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKF--GPRLL 246

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5911298  533 FAFGILCIAVGRVVVAF---TDSYEIMIGVFLLIGFGKAFrtIFSPL--IIPSYVPLNRLPAASGLqliFNTI 600
Cdd:cd17503 247 LLAGLLLLALGTLLLAFltpDTSLWLIILPLFIRGLGMGL--VFMPLntLALNSLPPEQIGDATAL---FNTI 314
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 45-220 1.26e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.20  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNF---FLFPALQQYGliyrvrMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLA 121
Cdd:cd17325 202 LALFLAIFVLAFafgALEPFLPLYA------AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  122 FLGVFLSAFCTTFWQYIIcLSAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQ 200
Cdd:cd17325 276 AVALLLLPLATSFWLLLL-LLALLGLGLGLVFPATLALLADIVPPEGRgTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA 354

                       170       180
                ....*....|....*....|
gi 5911298  201 GTILIYAGIamnAILCALTL 220
Cdd:cd17325 355 TPFLAAAAL---LLLAAVLF 371
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 44-217 1.48e-08

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 57.13  E-value: 1.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17428   1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:cd17428  81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160

                       170
                ....*....|....
gi 5911298  204 LIYAGIAMNAILCA 217
Cdd:cd17428 161 LIVGALALNLLACG 174
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
468-618 1.78e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.80  E-value: 1.78e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  468 LAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSL-LACMDISVRFLAPLAlekVKLDNRVLFAFGILCIAVGRVV 546
Cdd:COG2271  15 LFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAfFLGYALGQIPAGLLA---DRFGRRRVLAIGLLLWGLATLL 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 5911298  547 VAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAYGY 618
Cdd:COG2271  92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
 44-222 2.85e-08

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 56.32  E-value: 2.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17425   1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:cd17425  81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160

                       170
                ....*....|....*....
gi 5911298  204 LIYAGIAMNAILCALTLQP 222
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP 179
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 436-622 3.07e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.05  E-value: 3.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  436 EAEEEAKRRMTFFQKVSKFFDLDLLRDFTFVNLAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVR 515
Cdd:cd17325 173 EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQ 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  516 FLAPLALEKVklDNRVLFAFGILCIAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGlql 595
Cdd:cd17325 253 PPAGKLSDRI--GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMG--- 327

                       170       180       190
                ....*....|....*....|....*....|
gi 5911298  596 IFNTIFS--FAMGPIL-GILTEAYGYAATI 622
Cdd:cd17325 328 LFNTAFSlgMVLGPLLgGFLYDAFGFATPF 357
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
464-621 3.92e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.04  E-value: 3.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  464 TFVNLAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVKLdnRVLFAFGILCIAVG 543
Cdd:COG2223   6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP--RRVLLIGLLLLGIG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  544 RVVVAFTDSYEIMIGVFLLIGFGKAfrTIFSPLI--IPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAYGYAAT 621
Cdd:COG2223  84 LLLLALAVSYWLLLLLGLLLGIGGG--GSFAVGIalVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
 44-223 9.40e-08

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 54.50  E-value: 9.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17426   1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITglgPIFFPQ---VSTVLLGYYGAQ 200
Cdd:cd17426  81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGS---PVFLSTlapLNQWFFDIFGWR 157

                       170       180
                ....*....|....*....|...
gi 5911298  201 GTILIYAGIAMNAILCALTLQPV 223
Cdd:cd17426 158 GSFLILGGLLLNCCVAGSLMRPI 180
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
45-234 9.88e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.50  E-value: 9.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNnFFLFPALQQYGLIYRVrmQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLG 124
Cdd:COG2223 208 WLLSLLYFGT-FGSFIGFSSWLPPYLV--DQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALG 284

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  125 VFLSAFCT-TFWQYIICLsAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGT 202
Cdd:COG2223 285 LLLLALALgSLWLFLVLF-LLLGLALGGGNGAVFALVPDIFPTKNAgAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTA 363

                       170       180       190
                ....*....|....*....|....*....|..
gi 5911298  203 ILIYAGIAmnAILCALtlqpVLWHVKKPEKPV 234
Cdd:COG2223 364 AFLVFAVL--ALVALV----LTLLLYRRPRRA 389
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 459-617 1.11e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.35  E-value: 1.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  459 LLRDFTFVNLAVGMSIMMFGEMNFSVLTP-FILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKvKLDNRVLFAFGI 537
Cdd:cd06174 199 VLKNPGLWLLLLAIFLVNLAYYSFSTLLPlFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR-LIGRKPLLLIGL 277

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  538 LCIAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAYG 617
Cdd:cd06174 278 LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 76-237 1.55e-07

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 54.15  E-value: 1.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   76 LGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMA- 154
Cdd:cd17353  33 LGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYIt 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  155 ATSLAVNtYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTiLIYAGIAMNAI--LCALTLQ--PVLWHVKKP 230
Cdd:cd17353 113 PVSTAVK-WFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT-FLILGIIFLIIivIGAFLIRdpPKGWVPPGV 190


                ....*..
gi 5911298  231 EKPVHNT 237
Cdd:cd17353 191 DPLANNA 197
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 44-216 1.59e-07

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 53.98  E-value: 1.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17422   1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:cd17422  81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160

                       170
                ....*....|...
gi 5911298  204 LIYAGIAMNAILC 216
Cdd:cd17422 161 LVVGALQLNIVVC 173
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 45-220 1.91e-07

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 53.71  E-value: 1.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALqqygliyrvRMQSLGFDAKQTTTIVnVVMAISSLVG-IVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17352 191 GVSFAMLGFFVPFVYLPS---------YAKSLGIDESDAAFLL-SIIGISDIVGrILLGLLADKPRIGRLYLYIFTLLIL 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GV--FLSAFCTTFWQYIIClSAIFGIGLGLAMAATSLAVNTYFKLKR-RRATGFSWTITGLGPIFFPQVSTVLLGYYGAQ 200
Cdd:cd17352 261 GLslLAFPLATTYVGLIVF-SVLFGFCSGSYSSLTPVILADLVGLEKlSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDY 339

                       170       180
                ....*....|....*....|
gi 5911298  201 GTILIYAGIAMnaILCALTL 220
Cdd:cd17352 340 DAAFYFCGACL--LLSGVLL 357
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 45-221 2.33e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 53.35  E-value: 2.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALQQYGLIYRvrmQSLGFDAKQTttivNVVMAISSLVGIVNGAMF----RRFTFRQVALTGTSL 120
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFLLQ---ERGGGSAALI----GLALAIASLAGAIGALLFgrlkRRLGKRRLLAIGFAL 272

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  121 AFLGVFLSAFCTTFWQYIICLsAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFsWTITglgpIFFPQ-VSTVLLG--- 195
Cdd:cd17473 273 MALGFLLLALASGLWVVLLGA-ILAGLGFGLLLPTLNSWAMSLVPPELRgRAMGI-VTSA----FFLGQfLSPLVLGplv 346

                       170       180
                ....*....|....*....|....*...
gi 5911298  196 --YYGAQGTILIYAGIAMNAILCALTLQ 221
Cdd:cd17473 347 nlTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 73-252 2.44e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.35  E-value: 2.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   73 MQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIIcLSAIFGIGLGLA 152
Cdd:cd17325  23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL-ARFLQGLASAAV 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  153 M-AATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTILIYAGIAMNAILCALTLQPVLWHVKKPE 231
Cdd:cd17325 102 WpAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKR 181

                       170       180
                ....*....|....*....|.
gi 5911298  232 KPVHNTIEGIAETEKLQPELL 252
Cdd:cd17325 182 AVSAARLRSGLRLLLRDRRLL 202
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
 44-223 2.74e-07

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 53.28  E-value: 2.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17427   1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITglgPIFFPQVSTV---LLGYYGAQ 200
Cdd:cd17427  81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGS---PVFLSTLAPLnqfLFNQFGWR 157

                       170       180
                ....*....|....*....|...
gi 5911298  201 GTILIYAGIAMNAILCALTLQPV 223
Cdd:cd17427 158 GSFLILGGLLLNCCVAGSLMRPL 180
MFS_1 pfam07690
Major Facilitator Superfamily;
43-187 3.67e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.81  E-value: 3.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298     43 WGWVVCLAAGLNNFFLFPALQQYgliyrvrMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAF 122
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLY-------QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLI 276

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5911298    123 LGVFLSAFCTTFWQYIICLSAIFGIGLGLAM---AATSLAVNTYFKLKRRRATGFSWTITGLGPIFFP 187
Cdd:pfam07690 277 LAALGLLLLSLTLSSLWLLLALLLLGFGFGLvfpALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_1 pfam07690
Major Facilitator Superfamily;
433-607 4.19e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.42  E-value: 4.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    433 DNTEAEEEAKRRMTFFQKVSKFFDLDLLRDFTFVNLAVGMSIMMFGemnFSVLTPFILNSFGYTDTQISLVMSLLACMDI 512
Cdd:pfam07690 173 PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG---LLTYLPLYQEVLGLSALLAGLLLGLGGLLGA 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    513 SVRFLAPLALEKVKLDNRVLFA-FGILCIAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAAS 591
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLAlLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTAS 329

                         170
                  ....*....|....*.
gi 5911298    592 GLQLIFNTIfSFAMGP 607
Cdd:pfam07690 330 GLYNTAGSL-GGALGP 344
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
86-231 6.23e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.16  E-value: 6.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   86 IVNVVMAISSLVG-IVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLsAIFGIGLGLAMAATSLAVNTYF 164
Cdd:COG0738  47 LLLFAFFLGYLLAsLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL-FLLGLGLGLLDVAANPYVAALG 125

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5911298  165 KLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTILIYAGIAmnAILCALTLqpVLWHVKKPE 231
Cdd:COG0738 126 PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILA--VLLLLLAL--LFLRSKLPE 188
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 81-249 8.95e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 8.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   81 KQTTTIVNVVMAISSLV----GIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIIClSAIFGIGLGLAMAAT 156
Cdd:cd17473  31 PNSELLVPLLLTLPALFialfAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS-RALLGIGVAGIMTLA 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  157 SLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTvLLGYYGAQGTILIYAGiamnAILCALTlqpVLWHVKKPEKPVH 235
Cdd:cd17473 110 TALIGDYFEGEERaKMLGLQSAAMSLGGVVFLLLGG-ALAEIGWRAPFLVYLL----ALPVLIL---VLLFLPEPARKSK 181

                       170
                ....*....|....
gi 5911298  236 NTIEGIAETEKLQP 249
Cdd:cd17473 182 SAASPGAATAAALP 195
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 44-222 1.25e-06

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 51.26  E-value: 1.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17314   1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:cd17314  81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160

                       170
                ....*....|....*....
gi 5911298  204 LIYAGIAMNAILCALTLQP 222
Cdd:cd17314 161 TILGILAAIVLSVVSLLGF 179
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
45-179 1.31e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 50.74  E-value: 1.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALQQYGLIYrvrMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLG 124
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYL---QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 5911298  125 VFLSAFCTTFWQYIICLsAIFGIGLGLAMAATSLAVNTYFKlKRRRATGFSWTIT 179
Cdd:COG2814 287 LLLLALAGSLWLLLLAL-FLLGFGFGLLFPLLQALVAELAP-PEARGRASGLYNS 339
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
459-620 1.56e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.01  E-value: 1.56e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  459 LLRDFTFVNLAVGMSIMMFGEMNFSVLTP-FILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVKlDNRVLFAFGI 537
Cdd:COG0738 206 LLKNPRLLLGGLAIFLYVGAEGAIGDWLPlYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFG-PVRLLRLSAL 284

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  538 LCIaVGRVVVAFTDSYEIMIGVFLLIGFGKA--FRTIFSplIIPSYVPLNRLPAASGLqLIFnTIFSFAMGP-ILGILTE 614
Cdd:COG0738 285 LAA-VGLLLALLAPGPWLALIGLALVGLGLSlmFPTIFS--LALDGLGKRTAAAVSAV-LIM-GIVGGAIGPpLIGFLAD 359


                ....*.
gi 5911298  615 AYGYAA 620
Cdd:COG0738 360 AFGLRA 365
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
457-617 1.75e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.65  E-value: 1.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  457 LDLLRDFTFVNLAVGMSIMMFGEMNFS-VLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVKLdNRVLFAF 535
Cdd:COG2223 199 LEALRDPRFWLLSLLYFGTFGSFIGFSsWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG-RRVLLIV 277

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  536 GILCIAVGRVVVAFTDSYEIMIGVFLLIGF--GKAFRTIFSplIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILT 613
Cdd:COG2223 278 FALMALGLLLLALALGSLWLFLVLFLLLGLalGGGNGAVFA--LVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355


                ....
gi 5911298  614 EAYG 617
Cdd:COG2223 356 DATG 359
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 468-618 2.18e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.50  E-value: 2.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  468 LAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVKLdnRVLFAFGILCIAVGRVVV 547
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGR--RPVLLLGLLLFALGALLF 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5911298  548 AFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAYGY 618
Cdd:cd06174  79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF 149
MFS_1 pfam07690
Major Facilitator Superfamily;
468-632 3.32e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 49.72  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    468 LAVGMSIMMFGEMNFSV-LTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKvkLDNRVLFAFGILCIAVGRVV 546
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPaLPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR--FGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    547 VAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAYGYAATIHTIN 626
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158


                  ....*.
gi 5911298    627 ALTLLA 632
Cdd:pfam07690 159 ILSLLA 164
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 454-610 6.55e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 48.73  E-value: 6.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  454 FFDLDLLRDFTFVNLAVGMSIMMFGEMNFSVLTPFILNS-----FGYTDTQISLVMSLLACMDISVRFLAPLALEKVklD 528
Cdd:cd17504 168 LIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARV--G 245

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  529 NRVLFAFGILCIAVGRVVVAFTDSYEIMIGVF-LLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIFSfAMGP 607
Cdd:cd17504 246 PRRVLLIGLVISAVGLLLLALLHSSLWALVVAlLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGS-AIGP 324


                ...
gi 5911298  608 ILG 610
Cdd:cd17504 325 AIA 327
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 83-220 6.81e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 48.74  E-value: 6.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   83 TTTIVNVVMAISSLVGIV----NGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIIcLSAIFGIGLGLAMAATSL 158
Cdd:cd17489  29 SEAVAGLVVGLFTLAALLarpfAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLV-LRLIHGIGWGAFTTAAAT 107

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5911298  159 AVNTYFKlKRRRATGFSW--TITGLGPIFFPQVSTVLLGYYGAQGTILIYAGIAMNAILCALTL 220
Cdd:cd17489 108 LVADIIP-PSRRGEGIGYygLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 45-211 7.13e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 48.58  E-value: 7.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAmfRRFTFRQVALTGTSLAFLG 124
Cdd:cd06174 206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD--RLIGRKPLLLIGLLLMALG 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  125 VFLSAFCTTFWQYIICLsAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTI 203
Cdd:cd06174 284 LALLLLAPSLLLLLLLL-LLLGFGLGGLLPLSFALIAELFPPEIRgTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGA 362


                ....*...
gi 5911298  204 LIYAGIAM 211
Cdd:cd06174 363 FLVLAVLL 370
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 45-215 8.50e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 48.31  E-value: 8.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFP-ALqqygLIYRVrmQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17370 203 WLYLLAVALFALGNFSfAF----LILRA--QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLAL 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWqYIICLSAIFGIGLGLAMAATSLAVNTYFKlKRRRATGFSW--TITGLGPIffpqVSTVLLGY----Y 197
Cdd:cd17370 277 AYLGFALGSSLW-LLLLGFILWGLYMGAQESIERAAVADLVP-AELRGTAYGLfnTVVGIGWL----LASLIAGYlwdlI 350

                       170
                ....*....|....*...
gi 5911298  198 GAQGTILIYAGIAMNAIL 215
Cdd:cd17370 351 SPSAAFLFSAVLALIALL 368
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 68-224 1.36e-05

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 47.88  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   68 IYRVRMQS-LGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFG 146
Cdd:cd17424  24 IFFVEFQNyFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLASTGLILSSFATSLEYLYLTLGVLTG 103

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5911298  147 IGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTILIYAGIAMNAILCALTLQPVL 224
Cdd:cd17424 104 LGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRFLL 181
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 459-611 1.55e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 47.55  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  459 LLRDFTFVNLAvgMSIMMFGEMNFSVLTPFILNS-FGYTDTQISLVMSLLAcmdISVRFLAPLAlEKV--KLDNRVLFAF 535
Cdd:cd17321 166 LARTFSGAVLA--AFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLA---LAMLVAAPLA-GRLadRFGPRLVLVA 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  536 GILCIAVGRVVVAFT---DSYEIMIGVFLLIGFGKAFrtIFSPL--IIPSYVPLNRLPAASGlqlIFNTIFSFAMGpiLG 610
Cdd:cd17321 240 GLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLGLGL--FATPLtnAALSSVPKEKAGAASG---ILNTARQLGGA--LG 312


                .
gi 5911298  611 I 611
Cdd:cd17321 313 V 313
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 73-215 1.66e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.57  E-value: 1.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   73 MQSLGFDAKQTTtivnVVMAISSLVGIV-NGAMFRRFTFR----QVALTGTSLAFLGVFLSAFCTTFwQYIICLSAIFGI 147
Cdd:cd17330 202 KDRFGFSPSQIG----LLLALVGIAGILaQLLLIPRLAKRlgerKLLRLGLLLAIIGLLLLPFASSV-PLLVLAAAILAF 276

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 5911298  148 GLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTILIYAGIAMNAIL 215
Cdd:cd17330 277 GTGIVFPALSALLSKSVPSKEQgKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALF 345
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 44-220 1.93e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 47.21  E-value: 1.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLiyrvrmQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17316 182 LILLWFFISFGYYGLTTFLPTYLQ------TVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTF-WQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQG 201
Cdd:cd17316 256 LALPLFYLLSGsPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRaTGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335

                       170
                ....*....|....*....
gi 5911298  202 TILIYAGIAmnAILCALTL 220
Cdd:cd17316 336 VPALILALL--AIVALIVA 352
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 73-219 2.58e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.78  E-value: 2.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   73 MQSLGFDAKQTTTIVNV---VMAISSLVGivnGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQyIICLSAIFGIGL 149
Cdd:cd17321  23 ARDLGASPSQLQWVVNAyllAFAALLLLA---GRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAF-LIAARALQGIGA 98

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5911298  150 GLAMAATSLAVNTYFKLKRR-RATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTILIYAGIAMNAILCALT 219
Cdd:cd17321  99 AAIMPASLALIAATFPGERRgRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLART 169
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 465-622 3.62e-05

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 46.39  E-value: 3.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  465 FVNLAVGMSIMM-FGEMN-FSVLTPFILNSFGYTDTQISLVMSLL-ACMDISVRFLAPLAlekVKLDNRVLFAFGILCIA 541
Cdd:cd17352   3 VVVFASFLVNFFtDGILNsFGVLFVELLEEFGESTSDIAWIGSLLlGVSLFSGPLSSALV---NRFGCRPVAIAGGLLAA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  542 VGRVVVAFTDS-YEIMIGVFLLIGFGKAFrtIFSP--LIIPSYVpLNRLPAASGLQLIFNTIFSFAMGPILGILTEAYGY 618
Cdd:cd17352  80 LGLLLSSFATSlWQLYLTYGVLGGLGLGL--IYSPaiVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGW 156


                ....
gi 5911298  619 AATI 622
Cdd:cd17352 157 RGAL 160
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 436-617 4.49e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 46.06  E-value: 4.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  436 EAEEEAKRRMTFFQKVSKFFDLDLLRDFTFVNLaVGMSIMMFGEMNFsvlTPFILNSFGYTDTQISLVMSL-LACMDISV 514
Cdd:cd17490 172 EERREKKPVLTELKELLSVLKDKKLLFFSLLAI-LQQMITFSTTFGF---TPLIAKQLGASSFQLGLLSIIyLLPNALAS 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  515 RFLAPLALEKVKLDNRVLFAFGILCIAVgrVVVAFTDSYEIMIGVFLLIGFGKAFR-TIFSPLIIPSyVPLNRLPAASGL 593
Cdd:cd17490 248 LLSGTLFYKKLGERNTIIIGFLLLGAYC--FLIPFAPNLTLLYLLQALNGFGTGILfPLLMSLSIEG-VPAEQRSTAMGF 324

                       170       180
                ....*....|....*....|....*..
gi 5911298  594 qliFNTIFSFAM--GPIL-GILTEAYG 617
Cdd:cd17490 325 ---FQAIYALGMflGPVLvGIISEAFG 348
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 468-620 4.71e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.03  E-value: 4.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  468 LAVGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVKldNRVLFAFGILCIAVGRVVV 547
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG--RKRLLLLGLLLLAVSTLLF 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5911298  548 AFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGlqlIFNTIFSFAM--GPILG-ILTEAYGYAA 620
Cdd:cd17325  79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMG---IFSSAIGLGFliGPLLGgLLADALGYRA 151
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
45-224 5.74e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.05  E-value: 5.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNF--FLFPALQQYGLIYRvrmqsLGFDAKQtTTIVNVVMAISSLVGI-VNGAMFRRFTFRQVALTGTSLA 121
Cdd:COG2211 231 LLLLLAYLLFFLalALVAALLLYYFKYV-----LGLSAAL-VGLLLALYFLAALLGApLWPRLAKRFGKKKAFIIGLLLA 304

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  122 FLGVFLSAFCTTFWQY-IICLSAIFGIGLGL------AMAATSLAVNTYFKLKRRRATGFS--WTITGLGPIFFPQVSTV 192
Cdd:COG2211 305 ALGLLLLFFLGPGNLWlLLVLAALAGIGLGAilvlpwAMLADVVDYDEWKTGRRREGLYFGifTFAIKLGQALAGALAGL 384

                       170       180       190
                ....*....|....*....|....*....|..
gi 5911298  193 LLGYYGAQGTILIYAGiAMNAILCALTLQPVL 224
Cdd:COG2211 385 LLALFGYVAGAAQSPS-ALTGIRLLFFLLPAV 415
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 46-160 8.04e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.24  E-value: 8.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   46 VVCLAAGLNNFFLFPALQQygliyrvrmqSLGFDAKQT---TTIVNVVMAISSLVGivnGAMFRRFTFRQVALTGTSLAF 122
Cdd:cd17321 179 LLGAALGGLLFLLPLYLQG----------VLGYSPLQAglaLLPLALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTA 245

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 5911298  123 LGVFLSAFC---TTFWQYIICLsAIFGIGLGLAMAATSLAV 160
Cdd:cd17321 246 VGLLLLALLgadSSVWLLLPGL-VLLGLGLGLFATPLTNAA 285
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 468-617 9.86e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 44.80  E-value: 9.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  468 LAVGMSIMMFGeMNFSVLT---PFILNSFGYTDTQISLVMS--LLACMdISVRFLAPLAlekVKLDNRVLFAFGILCIAV 542
Cdd:COG0477  17 LALALGTFLEG-LDFTIVNvalPSIAADLGASSAQLGWIVSayLLGRA-IGLLLFGRLG---DRYGRKRVLLIGLLLFGL 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5911298  543 GRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIfSFAMGPILG-ILTEAYG 617
Cdd:COG0477  92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGL-GLALGPLLGgLLVAALG 166
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 74-162 1.17e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.87  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   74 QSLGFDAKQTTtIVNVVMAISSLVGI-VNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCT--TFWQYIICLSAIFGIGLG 150
Cdd:cd17503 207 NVLGYSAFESG-LVLAPGGLASAILSpLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTpdTSLWLIILPLFIRGLGMG 285

                        90
                ....*....|...
gi 5911298  151 LA-MAATSLAVNT 162
Cdd:cd17503 286 LVfMPLNTLALNS 298
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 482-621 1.52e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.47  E-value: 1.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  482 FSVLTPFILNSFGYTDTQISLVMSLLAcmdISVRFLAPL---ALEKVKLdnRVLFAFGILCIAVGRVVVAFTDSYEIMIG 558
Cdd:cd17478  15 LPALLPLLIAKLGLSYAQAGLLVSVFS---ITSSLLQPLfgyLADRKPR--RYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 5911298  559 VFLLIGFGKAfrtIFSPL---IIPSYVPLNRLPAASglqlIFNTI--FSFAMGPIL-GILTEAYGYAAT 621
Cdd:cd17478  90 LVALAGIGSA---AFHPEgarLASQAAGGRRGLAMS----IFSVGgnLGFALGPLIaAALVALFGGLGL 151
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 49-155 1.76e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 44.11  E-value: 1.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   49 LAAGLNNFFLFpalqqYGLIYRVRM-QSLGFDAkqTTTIVNVVMAISSLVGIV----NGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17504 187 LLAGFGMFMVF-----QLLPQLLQLpTPTGFGL--GITEAGLLLLPGALVMLIagplAGRLIARVGPRRVLLIGLVISAV 259

                        90       100       110
                ....*....|....*....|....*....|...
gi 5911298  124 G-VFLSAFCTTFWQyIICLSAIFGIGLGLAMAA 155
Cdd:cd17504 260 GlLLLALLHSSLWA-LVVALLLIGIGLGLAFAS 291
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 435-622 2.04e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.14  E-value: 2.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  435 TEAEEEAKRRMTFFQKVSKFFDLdLLRDFTFVNLAVGMSIMMFGEMNFSVLTP-FILNSFGYTDTQISLVMSLLACMDIS 513
Cdd:cd06173 181 PPPAAPGESSSLLLRDLREGLRY-LRRSPLLRLLLLALALFALLGGALTVLLPlLAKEVLGGGAAGYGLLLAAFGVGALL 259

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  514 VRFLAPLALEKVKLdnRVLFAFGILCIAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGL 593
Cdd:cd06173 260 GALLLGRLSKRRRR--GRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSV 337

                       170       180
                ....*....|....*....|....*....
gi 5911298  594 QLIFNTIFSFAMGPILGILTEAYGYAATI 622
Cdd:cd06173 338 YNALNSGAMPLGALLAGLLADALGLSAVF 366
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 106-198 3.81e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.33  E-value: 3.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  106 RRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIIcLSAIFGIGLGLAM-AATSLAVNTYFKLKRRRATGFSWTITGLGPI 184
Cdd:cd17503  56 DRFGTRRLFLTALALFTLGSLLCGLAPNLASLII-FRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVGLVILLAPA 134

                        90
                ....*....|....
gi 5911298  185 FFPQVSTVLLGYYG 198
Cdd:cd17503 135 IGPTLGGWLTDNLS 148
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 55-221 5.13e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.98  E-value: 5.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   55 NFFLFPALQQYGLIYRVRMQSLGFDakqTTTIVNVVMAISSLVGIVN----GAMFRRFTFRQVALTGTSLAFLGVFLSAF 130
Cdd:cd17329 209 SFLISLIYFQLESTLPVYVVEILGL---GESLLGLLLALNALLIVLLqfpvARLVERFRLRKILMIGILLFAIGFAVLAF 285

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  131 CTTFWQYIICLsAIFGIGLGLAMAATSLAVNTYF-KLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTILIYAGI 209
Cdd:cd17329 286 ANTLAVLILAM-IVLTLGEMLVFPAVQTLVAALApPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAAL 364

                       170
                ....*....|..
gi 5911298  210 AMNAILCALTLQ 221
Cdd:cd17329 365 GLIAAALLLGLQ 376
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
459-617 5.62e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 42.94  E-value: 5.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  459 LLRDFTFVNLAVGMSIMMFgeMNFSVLT--PFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVKLDNRVLFAFG 536
Cdd:COG2807 211 LWRSPLAWLLTLFFGLQSL--LYYAVVAwlPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG 288

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  537 ILCIAvGRVVVAFTDSYEIMIGVFLL-IGFGKAFrtifsPLIIpsYVPLNRLP------AASGLQLIFNTIFSFAMGPIL 609
Cdd:COG2807 289 LLGLA-GLLGLLLAPGSLPWLWAVLLgLGQGGLF-----PLAL--TLIGLRARtpaeaaALSGMAQSVGYLLAALGPLLV 360


                ....*...
gi 5911298  610 GILTEAYG 617
Cdd:COG2807 361 GALHDATG 368
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 441-612 7.44e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.18  E-value: 7.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  441 AKRRMTFFQKVSKFFdLDLLRDFTFVNLAVGMSIMMFGEMNFSVLTPFIL-NSFGYTDTQISLVMSLLACMDISVRFLAP 519
Cdd:cd17320 180 EEKRKPLLSSLLRAY-KRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYiEQLGLSPAQFGLLFALNAIALILGSLLNG 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  520 LALEKVKLDNRVLFAFGILCIA-VGRVVVAFT---DSYEIMIGVFLL-IGFGKAFRTIFSPLIIPSYvplNRLPAASGLQ 594
Cdd:cd17320 259 RLVRRFGPRRLLRLGLLLLLAAaLVLLLAALLgglSLWPLVAPLFLIfFGFGLIFPNATSLALEPFP---HVAGTASALL 335

                       170
                ....*....|....*...
gi 5911298  595 LIFNTIFSFAMGPILGIL 612
Cdd:cd17320 336 GFLQFLIGALAGALVGLL 353
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 470-570 1.04e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 41.98  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298    470 VGMSIMMFGEMNFSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVklDNRVLFAFGILCIAVGRVVVAF 549
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRS--NPRVFLPIGLILCAIVNLFFGF 79

                          90       100
                  ....*....|....*....|.
gi 5911298    550 TDSYEIMIGVFLLIGFGKAFR 570
Cdd:TIGR00881  80 STSLWVMAALWALNGIFQGMG 100
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 45-237 1.16e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 1.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLA---AGLNNFFLFPALQQYGliyrvrmQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLA 121
Cdd:cd17474   2 YAVFFAtllAVLGVSIVDPILPAIA-------EALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLF 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  122 FLGVFLSAFCTTFWQYIIcLSAIFGIGLGLAMA-ATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPqvstvLLGyyGAQ 200
Cdd:cd17474  75 GIGGLLCGLSDSFALLLA-GRALQGIGAAGLGPlALTLIGDLFEGGERAKAMGLYEAALGLGIAVGP-----LLG--GLL 146

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 5911298  201 GTILIYAGIAMNAILCALTLQPVLWHVKKPEKPVHNT 237
Cdd:cd17474 147 AAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSS 183
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 73-218 1.21e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.44  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   73 MQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMF-RRFTFRQVALTGTSLAFLGVFLSAFCTTFWQyIICLSAIFGIGLGL 151
Cdd:cd17490 222 AKQLGASSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL-LYLLQALNGFGTGI 300

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5911298  152 AMAA-TSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGtilIYAGIAMNAILCAL 218
Cdd:cd17490 301 LFPLlMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQT---GFFVIGVIALLAAI 365
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
461-569 1.41e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 41.38  E-value: 1.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  461 RDFTFVNLAVGMSIMMFGEMN--FSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKvkLDNRVLFAFGIL 538
Cdd:COG0738   4 KNYRRALIAIYLLFFLWGFATalWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDR--FGYKRGLLLGLL 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 5911298  539 CIAVGRVVVAFTDSYEIMIGVFLLIGFGKAF 569
Cdd:COG0738  82 LMALGLLLFALAPSYPLLLLALFLLGLGLGL 112
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 45-197 1.61e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.06  E-value: 1.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNN---FFLFPalqqYGLIYRVRMQSLGFdakqttTIVNVVMAISSLVGIV----NGAMFRRFTFRQVALTG 117
Cdd:cd17329   2 WVLLIGSFLNRlgfFMVWP----FMAIYLHQQLGLSA------SIVGLVLALSAVAGIVasliGGRLADRFGRKPVMLAG 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  118 TSLAFLGVFLSAFCTTFWQYIIcLSAIFGIGLGLAM-AATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGY 196
Cdd:cd17329  72 LLLRALGFALLGFAHSPWLFAI-ALVLTGFGGGLFEpASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150


                .
gi 5911298  197 Y 197
Cdd:cd17329 151 S 151
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 73-237 1.74e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.00  E-value: 1.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   73 MQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIIclsAIFGIGLGLA 152
Cdd:cd17478  23 IAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL---LVALAGIGSA 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  153 M---AATSLAVNTYfklKRRRATGFSWTITG------LGPIFfpqvSTVLLGYYGAQGT--ILIYAGIAMnAILCALTLQ 221
Cdd:cd17478 100 AfhpEGARLASQAA---GGRRGLAMSIFSVGgnlgfaLGPLI----AAALVALFGGLGLliLLIIPGLAV-ALLLLRLRP 171

                       170
                ....*....|....*.
gi 5911298  222 PVLWHVKKPEKPVHNT 237
Cdd:cd17478 172 LKKPEAKKAAAKSSAR 187
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 89-237 2.64e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 40.61  E-value: 2.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   89 VVMAISSLVGIVNGAMF-----RRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLSAIFGIGlGLAMAAT-SLAVNT 162
Cdd:cd17471  36 IFMTLSALSGIVVSQWLgrlsdRGGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLG-AAAFPQLfALAREY 114

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5911298  163 YFKLKRRRATGFSWTI---TGLGPIFFPQVSTVLLGYYGAQGTILIYAGIamnAILCALTlqpVLWHVKKPEKPVHNT 237
Cdd:cd17471 115 ADRSSGRDATLFNSVLraaFSLAWVIGPPLAFLLLDVLGFTGLFLLAALL---YLVVALL---VLFLLPSVKPPAQKA 186
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 44-218 2.85e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 40.56  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNfflfpalqqygliyRVRMQSLGFDAkqttTIVNVVMAISSLVGIVnGAMF-------RRFTFRQVA-- 114
Cdd:cd06176  13 GMMVVLTTGTLN--------------RVMIVELGLPA----TLVGLLIALHYLVAPL-RVWIghrsdthPLRGYRRTPyi 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  115 LTGTSLAFLGVFLSAFCT------TFWQYIICLSAIFG-IGLGLAMAATSLA--VNTYFKLKRR-RATGFSWTITGLGPI 184
Cdd:cd06176  74 WLGMLLLALGLALAPFAAlllagaAFWLGLALAVLAFLlYGIGVGAAGTAFLalLADLTPEERRpRAVTVVWTMLILGII 153

                       170       180       190
                ....*....|....*....|....*....|....
gi 5911298  185 FFPQVSTVLLGYYGAQGTILIYAGIAMNAILCAL 218
Cdd:cd06176 154 VTAIVFGRLLDPYSPERLIQVFQIVALVALLLAL 187
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 485-621 3.58e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 3.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  485 LTPFILNSFGYTDTQISLVMSLLA-CMDISVRFLAPLALekvKLDNRVLFAFGILCIAVGRVVVAFTDSYEIMIGVFLLI 563
Cdd:cd17324  21 LLPDIARDFGVSVAQAGLLVSAYAlGYALGALLLGPLSD---RIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALA 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5911298  564 GFGKAfrtIFSPLIIP---SYVPLNRLPAASGLQLIFNTIFSFAMGPILGILTEAYGYAAT 621
Cdd:cd17324  98 GLAHG---GFWAIAAAyaaDLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 475-566 3.64e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 40.00  E-value: 3.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  475 MMFGEMNFS--VLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEkvKLDNRVLFAFGILCIAVGRVVVAFTDS 552
Cdd:cd17333   6 FSNGLTDALlgILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMK--RLGRRRTLILGLLLISLALALIFATPS 83

                        90
                ....*....|....
gi 5911298  553 YEIMIGVFLLIGFG 566
Cdd:cd17333  84 IYLFVVLMFLAGLG 97
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 45-160 3.88e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 39.85  E-value: 3.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFpalqqyGLIYRV--RMQS-LGFDAKQTTTIVnVVMAISSLVGIVNGAMFRRFT--FRQVALTGTS 119
Cdd:cd17502 170 LLSSIFGFLFGGALF------GLIYYLplYFQLvLGDSATKSGVRL-LPLIIGLVIGSIISGALISKTgrYKPLIVIGTI 242

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 5911298  120 LAFLGVFLSAFC---TTFWQYIICLsAIFGIGLGLAMAATSLAV 160
Cdd:cd17502 243 LMSVGAGLLTTLtldTSKWLLIGYL-ILLGLGLGIGFQQPLVAV 285
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 73-215 4.48e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 4.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   73 MQSLGFDAkqtTTIVNVVMAISSLV-GIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIIcLSAIFGIGLGL 151
Cdd:cd17489 221 AAERGISN---AGLFFTVYAIALLLsRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLL-AAVLYGLGFGL 296

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  152 AM-AATSLAVNTYFKLKRRRATGfSWTIT-----GLGPIFFpqvsTVLLGYYGAQGTILIYAGIAMNAIL 215
Cdd:cd17489 297 LFpALQALAVDLVPPHRRGAANG-TFFIFfdlgiGLGGLLL----GLVAELFGYRAMFLLAAVVVLLALV 361
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 62-225 5.03e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.49  E-value: 5.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   62 LQQYGLIYRVRMQSLGFDAKQTTTIVNVV---MAISSLVGivnGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYI 138
Cdd:cd17365  15 LAVMGFVAPALAQDWGLSPAQLGPVGSAAlfgMAIGALLA---GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLA 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  139 IcLSAIFGIGLGLAMaATSLAVNTYFKLKRRRATGFSWTITG--LGPIFFPQVSTVLLGYYGAQGTILIyAGIAMNAILC 216
Cdd:cd17365  92 L-LRFLTGLGLGAAM-PNAITLVSEYAPARRRSLAVTLMFCGypLGAALGGFLAAALIPAFGWRSVFLL-GGVPPLILLP 168


                ....*....
gi 5911298  217 ALTLQPVLW 225
Cdd:cd17365 169 LLRGTLLLW 177
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 62-231 5.09e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 39.59  E-value: 5.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   62 LQQYGLIYRVRMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICl 141
Cdd:cd17371  15 LLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL- 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  142 SAIFGIGLGLAMAATSLAVNTYFKLKRR-RATGF---SWTITGLGPIFF-PQVSTVLLGYYGAQGTILIyagiamnAILC 216
Cdd:cd17371  94 RALAGLGFGGEWAAGAALMAEYVPARHRgKALGYvqsGWAVGWLLATLLaALLFPLLPPEIAWRVLFLL-------GALP 166

                       170
                ....*....|....*
gi 5911298  217 ALTLQPVLWHVKKPE 231
Cdd:cd17371 167 ALLVLFIRRFVKEPP 181
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 459-618 7.38e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.13  E-value: 7.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  459 LLRDFTFVNLAVGMSIMMFGEMNFSVLTP-FILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEKVKLdnRVLFAFGI 537
Cdd:cd17329 196 VLRDRAFLLFLLASFLISLIYFQLESTLPvYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRL--RKILMIGI 273

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  538 LCIAVGRVVVAFTDSYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLPAASGLQLIFNTIfSFAMGPILG-ILTEAY 616
Cdd:cd17329 274 LLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGL-GRAIGPLVGgLLLDLL 352


                ..
gi 5911298  617 GY 618
Cdd:cd17329 353 GP 354
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 45-216 8.10e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 38.84  E-value: 8.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGfdakqtttIVNVVMAISSLVGIV-NGAMFRRFTFRQVALTGTSLAFL 123
Cdd:cd17333   2 YISFFSNGLTDALLGILGPSLEEAFNLNVADVS--------VIFSSQNAGYLIGSLlAGFLMKRLGRRRTLILGLLLISL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  124 GVFLSAFCTTFWqYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLG-----YYG 198
Cdd:cd17333  74 ALALIFATPSIY-LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTselswSWA 152

                       170
                ....*....|....*...
gi 5911298  199 AQGTILIYAGIAMNAILC 216
Cdd:cd17333 153 YLIIGLIYLLLAILILLT 170
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
45-220 8.16e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.09  E-value: 8.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   45 WVVCLAAGLNNFFLF------PALqqygliyrvrMQSLGFDAKQTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGT 118
Cdd:COG2807 218 WLLTLFFGLQSLLYYavvawlPPI----------LRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLL 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  119 S-LAFLGVFLSAFCTTFWQYIICLsaIFGIGLGLAMAATSLAVNTYFKLKRRRAT------GFSWTITGLGPIFFPQVST 191
Cdd:COG2807 288 GlLGLAGLLGLLLAPGSLPWLWAV--LLGLGQGGLFPLALTLIGLRARTPAEAAAlsgmaqSVGYLLAALGPLLVGALHD 365

                       170       180
                ....*....|....*....|....*....
gi 5911298  192 VLLGYygaQGTILIYAGIAMNAILCALTL 220
Cdd:COG2807 366 ATGSW---TAALLLLAALAVLMLVAGLLA 391
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
 44-233 8.91e-03

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 39.01  E-value: 8.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   44 GWVVCLAAGLNNFFLFPALQQYGLIYRVRMQSLGF--DAK---QTTTIVNVVMAISSLVGIVNGAMFRRFTFRQVALTGT 118
Cdd:cd17464   1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGSkdDAQmrfKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  119 SLAFLGVFLSAFCTTFWQYIICLSAIFGIGLGLAMAATSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYG 198
Cdd:cd17464  81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160

                       170       180       190
                ....*....|....*....|....*....|....*
gi 5911298  199 AQGTILIYAGIAMNAILCALTLQPVLWHVKKPEKP 233
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGK 195
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 76-215 9.49e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 9.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298   76 LGFDAKQTTTIVNVVMAISSLVGIVnGAMF------RRFTFRQVALTGTSLAFLGVFLSAFCTTFWQYIICLsAIFGIGL 149
Cdd:cd17474 225 LELLYGISPIIIGLLFAGWSVLLAL-GSLFvgrllkKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAI-VLFGLGL 302

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5911298  150 GLAMAA-TSLAVNTYFKLKRRRATGFSWTITGLGPIFFPQVSTVLLGYYGAQGTILIYAGIAMNAIL 215
Cdd:cd17474 303 GLNLPLlTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 468-621 9.82e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 38.93  E-value: 9.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5911298  468 LAVGMSIMMFGEMN-FSVLTPFILNSFGYTDTQISLVMSLLACMDISVRFLAPLALEkvKLDNRVLFAFGILCIAVGRVV 546
Cdd:cd17314   7 VSFLLSAMSTGFILsWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIAD--SFGPRPLMALAGIMVLAGYTY 84

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5911298  547 VAFTD-SYEIMIGVFLLIGFGKAFRTIFSPLIIPSYVPLNRLpAASGLQLIFNTIFSFAMGPILGILTEAYGYAAT 621
Cdd:cd17314  85 LSYVFnSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKG-LALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH