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Conserved domains on  [gi|6636382|gb|AAF20164|]
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NAD+-specific isocitrate dehydrogenase b subunit, partial [Homo sapiens]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
1-151 2.33e-73

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00175:

Pssm-ID: 444908  Cd Length: 333  Bit Score: 222.64  E-value: 2.33e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382      1 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARH 80
Cdd:TIGR00175 183 LNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEPGVRH 262

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6636382     81 PFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 151
Cdd:TIGR00175 263 TGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGTATTSDFTEAVIKRL 333
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 1-151 2.33e-73

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 222.64  E-value: 2.33e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382      1 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARH 80
Cdd:TIGR00175 183 LNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEPGVRH 262

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6636382     81 PFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 151
Cdd:TIGR00175 263 TGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGTATTSDFTEAVIKRL 333
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 1-151 8.27e-52

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 168.52  E-value: 8.27e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     1 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVP-GESYSAEYAVFEtgAR 79
Cdd:PLN00118 222 LKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPsCNIGENGLALAE--AV 299

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6636382    80 HPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 151
Cdd:PLN00118 300 HGSAPDIaGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 1-151 1.63e-47

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 156.71  E-value: 1.63e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382    1 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgAR 79
Cdd:COG0473 197 REVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PV 274

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6636382   80 H---PfaQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAvKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 151
Cdd:COG0473 275 HgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAA-VEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
2-147 9.04e-39

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 134.34  E-value: 9.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382      2 QCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARH 80
Cdd:pfam00180 198 IVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVH 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6636382     81 PFAQAV-GRNIANPTAMLLSASNMLRH-LNLEYHSSMIADAvKKVIKVGKVRTRDMGG---YSTTTDFIKSV 147
Cdd:pfam00180 276 GSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAA-VLKVLESGIRTGDLAGsatYVSTSEFGEAV 346
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 1-151 2.33e-73

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 222.64  E-value: 2.33e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382      1 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARH 80
Cdd:TIGR00175 183 LNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEPGVRH 262

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6636382     81 PFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 151
Cdd:TIGR00175 263 TGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKAVLSTIAEGKNRTKDLGGTATTSDFTEAVIKRL 333
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 1-151 8.27e-52

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 168.52  E-value: 8.27e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     1 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVP-GESYSAEYAVFEtgAR 79
Cdd:PLN00118 222 LKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPsCNIGENGLALAE--AV 299

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6636382    80 HPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 151
Cdd:PLN00118 300 HGSAPDIaGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNAILNTIAEGKYRTADLGGSSTTTDFTKAICDHL 372
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 1-152 2.74e-51

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 166.96  E-value: 2.74e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     1 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARH 80
Cdd:PLN00123 206 LESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGADHAVFEQGASA 285

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6636382    81 ---PFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQ 152
Cdd:PLN00123 286 gnvGNEKLVEQKKANPVALLLSSAMMLRHLQFPSFADRLETAVKRVIAEGKYRTKDLGGSSTTQEVVDAVIANLD 360
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 1-151 4.21e-48

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 157.96  E-value: 4.21e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     1 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARH 80
Cdd:PRK08997 185 LKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDAAIFE--AVH 262

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6636382    81 PFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 151
Cdd:PRK08997 263 GSAPDIaGKNLANPTSVILAAIQMLEYLGMPDKAERIRKAIVAVIEAGDRTTRDLGGTHGTTDFTQAVIDRL 334
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 1-151 1.63e-47

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 156.71  E-value: 1.63e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382    1 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgAR 79
Cdd:COG0473 197 REVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PV 274

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6636382   80 H---PfaQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAvKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHL 151
Cdd:COG0473 275 HgsaP--DIAGKGIANPIATILSAAMMLRHLGEEEAADAIEAA-VEKVLAEGVRTPDLGGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
2-147 9.04e-39

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 134.34  E-value: 9.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382      2 QCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARH 80
Cdd:pfam00180 198 IVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFGDILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVH 275

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6636382     81 PFAQAV-GRNIANPTAMLLSASNMLRH-LNLEYHSSMIADAvKKVIKVGKVRTRDMGG---YSTTTDFIKSV 147
Cdd:pfam00180 276 GSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAA-VLKVLESGIRTGDLAGsatYVSTSEFGEAV 346
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
5-119 3.75e-33

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 121.54  E-value: 3.75e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     5 EEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFAQ 84
Cdd:PRK09222 191 DEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEYAMFE--AVHGSAP 268

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 6636382    85 AV-GRNIANPTAMLLSASNMLRHLNLEYHSSMIADA 119
Cdd:PRK09222 269 DIaGKNIANPSGLLNAAVMMLVHIGQFDIAELIENA 304
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 4-151 6.96e-31

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 113.31  E-value: 6.96e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     4 CEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA 83
Cdd:PRK14025 185 FYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDKYGLFE--PVHGSA 262

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6636382    84 -QAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVrTRDMGGYSTTTDFIKSVIGHL 151
Cdd:PRK14025 263 pDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKALEEVLALGLT-TPDLGGNLSTMEMAEEVAKRV 330
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 5-154 1.74e-28

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 107.49  E-value: 1.74e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     5 EEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFETGarHPFA 83
Cdd:PRK00772 206 TEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPI--HGSA 283

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6636382    84 -QAVGRNIANPTAMLLSASNMLRH-LNLEYHSSMIADAvKKVIKVGKVRTRDM---GGYSTTTDFIKSVIGHLQTK 154
Cdd:PRK00772 284 pDIAGKGIANPIATILSAAMMLRYsLGLEEAADAIEAA-VEKVLAQGYRTADIaegGGKVSTSEMGDAILAALAEG 358
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 5-140 2.98e-21

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 87.67  E-value: 2.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     5 EEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYA---VFET--GAR 79
Cdd:PRK03437 202 DEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTnpsMFEPvhGSA 281

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6636382    80 HPFAqavGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAvkkviKVGKVRTRDMGGYSTT 140
Cdd:PRK03437 282 PDIA---GQGIADPTAAILSVALLLDHLGEEDAAARIEAA-----VEADLAERGKMGRSTA 334
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 7-119 5.80e-14

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 67.79  E-value: 5.80e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     7 VAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAV 86
Cdd:PLN02329 253 LASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIA 332

                         90       100       110
                 ....*....|....*....|....*....|....
gi 6636382    87 GRNIANPTAMLLSASNMLRH-LNLEYHSSMIADA 119
Cdd:PLN02329 333 GQDKANPLATILSAAMLLKYgLGEEKAAKRIEDA 366
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 13-107 1.35e-13

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 66.67  E-value: 1.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382   13 KIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGE--SYSAeYAVFE----TGARHpfaqaV 86
Cdd:COG0538 264 KIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGAniGDDG-GAEFEathgTAPKY-----A 337

                        90       100
                ....*....|....*....|.
gi 6636382   87 GRNIANPTAMLLSASNMLRHL 107
Cdd:COG0538 338 GKDSTNPGSLILSGTMMLRHR 358
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
5-119 2.24e-12

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 63.31  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     5 EEVAELYP------KIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgA 78
Cdd:PRK06451 253 EEVTKNYNgvppsgKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE--A 330

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 6636382    79 RHPFA-QAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADA 119
Cdd:PRK06451 331 IHGTApKYAGKNVANPTGIIKGGELMLRFMGWDKAADLIDKA 372
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 13-108 6.16e-12

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 62.00  E-value: 6.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382    13 KIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNII-DNLAAGlVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNI 90
Cdd:PRK07006 267 EIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYIsDALAAQ-VGGIGIAPGANINDGHAIFE--ATHGTApKYAGLDK 343

                         90
                 ....*....|....*...
gi 6636382    91 ANPTAMLLSASNMLRHLN 108
Cdd:PRK07006 344 VNPGSVILSAEMMLRHMG 361
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
2-107 1.41e-07

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 49.33  E-value: 1.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6636382     2 QCCEEVAELYPKI-------KFETMII------DNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYS 68
Cdd:PRK07362 307 AICAEVKEVLDSIwsshgngKWKEKVLvddriaDSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIG 386

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 6636382    69 AEYAVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHL 107
Cdd:PRK07362 387 DNAAIFE--ATHGTApKHAGLDRINPGSVILSGVMMLEYL 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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