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Conserved domains on  [gi|6650603|gb|AAF21932|]
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organic cation transporter 1 [Caenorhabditis elegans]

Protein Classification

SLC22 family MFS transporter( domain architecture ID 13022872)

SLC22 (Solute carrier 22) family MFS transporter similar to Caenorhabditis elegans organic cation transporter 1; the SLC22 family includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs)

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
111-509 3.46e-120

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 358.05  E-value: 3.46e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  111 GWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIES 190
Cdd:cd17317   1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  191 FIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFF 270
Cdd:cd17317  81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  271 LPesprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrRKTLIVTYIW 350
Cdd:cd17317 161 LP--------------------------------------------------------------------RRTIIVGLIW 172
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  351 VMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVASA 430
Cdd:cd17317 173 FVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTL 252
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6650603  431 SFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTFFLP 509
Cdd:cd17317 253 ALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
111-509 3.46e-120

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 358.05  E-value: 3.46e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  111 GWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIES 190
Cdd:cd17317   1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  191 FIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFF 270
Cdd:cd17317  81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  271 LPesprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrRKTLIVTYIW 350
Cdd:cd17317 161 LP--------------------------------------------------------------------RRTIIVGLIW 172
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  351 VMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVASA 430
Cdd:cd17317 173 FVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTL 252
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6650603  431 SFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTFFLP 509
Cdd:cd17317 253 ALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
17-519 1.01e-118

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 360.49  E-value: 1.01e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603     17 GNYGTYQIVFFFIICLPtSLPSAFSAFNIPFVVGNPPHTCHIPE--------GKEYLRPLTNDTQILSCKQYNETQINVF 88
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALP-IALLAFHFVLIVFLGATPEHHCRLPDaanlssrcELNLTLPRLPDGRPESCLRFMVDQWANP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603     89 RAFTSAPVDTYS-DRISLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRS 167
Cdd:TIGR00898  80 SLLGCEPLKLSDlGLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    168 FFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFI 247
Cdd:TIGR00898 160 LLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    248 RRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADAKKQLKKIAKMNGKSnvdvdeLVDSMKNHQNAAEEKETKRS 327
Cdd:TIGR00898 240 PDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK------LPAEVLSLSLEKDLSSSKKQ 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    328 HNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMI 407
Cdd:TIGR00898 314 YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLL 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    408 VCGIGCVSAMFMPDGYPWLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVK 487
Cdd:TIGR00898 394 LAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWL 473
                         490       500       510
                  ....*....|....*....|....*....|..
gi 6650603    488 ILPLLIMGLMALSAGILTFFLPETLGAPLPMT 519
Cdd:TIGR00898 474 FLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
Sugar_tr pfam00083
Sugar (and other) transporter;
136-516 5.34e-27

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 113.91  E-value: 5.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    136 WIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIIL---RFFTGLAFPALFQIPFII 212
Cdd:pfam00083  47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMY 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    213 CMEFMGNSGRifsGLMTSLFFgAAMALLGVVAMFI----------RRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVG 282
Cdd:pfam00083 127 ISEIAPKKLR---GALGSLYQ-LAITFGILLAYIFglglnktsnsDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKG 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    283 KWADAKKQLKKIakmNGKSNVD--VDELVDSMknhqnaaEEKETKRSHNVTDLFKTPNLRRKTLIVTYIWV------MNA 354
Cdd:pfam00083 203 RLEEAREVLAKL---RGVPDVDreLDEIKDSL-------EAGQEAEKASWKELFSTKTRRQRLLIGVMLQIfqqltgINA 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    355 IIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTL---AATMIVCGIG-CVSAMFMPDGYPW----- 425
Cdd:pfam00083 273 IFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLllgAAGMAICFVIlGIVALLGVSKSDWagiva 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    426 LVASASFIGKFGVGSGfAVIYIFAGELYPTVVRAIGMGMSSMV--AGSGL--LLAPHIVNLGKIVKIlPLLIMGLMALSA 501
Cdd:pfam00083 353 IVFIALFIAFFAMGWG-PVPWVIVSELFPLSVRSKAMALATAAnwLANFLigFLFPIITDAIGLGYT-FFIFAGLLVLFI 430
                         410
                  ....*....|....*
gi 6650603    502 GILTFFLPETLGAPL 516
Cdd:pfam00083 431 IFVFFFVPETKGRTL 445
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
135-472 1.48e-22

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 99.28  E-value: 1.48e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  135 AWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICM 214
Cdd:COG2814  45 AQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIA 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  215 EFM--GNSGRIFSGLMTSLFFGAAMA-LLGVVAMFIRRWRqLTFFCNAPFAF--YIIYYFFLPESPRwsvsvgkwadakk 289
Cdd:COG2814 125 DLVppERRGRALGLLGAGLGLGPALGpLLGGLLADLFGWR-WVFLVNAVLALlaLLLLLRLLPESRP------------- 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  290 qlkkiakmngksnvdvdelvdsmknhqnaaeEKETKRSHNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTL---NVSN 366
Cdd:COG2814 191 -------------------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLylqEVLG 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  367 LPVDDY-WSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCvsAMFMPDGYPWLVASASFIGKFGVGSGFAVI 445
Cdd:COG2814 240 LSASAAgLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL--LLLALAGSLWLLLLALFLLGFGFGLLFPLL 317
                       330       340
                ....*....|....*....|....*..
gi 6650603  446 YIFAGELYPTVVRAIGMGMSSMVAGSG 472
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLG 344
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
123-504 3.15e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 52.66  E-value: 3.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   123 LVTEFNLVCDQQAWI-EISTTSFYVGSFIGnclfGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGL- 200
Cdd:PRK11551  41 MAQEFGLDVAQMGWAfSAGILGLLPGALLG----GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVg 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   201 ---AFPALFQipfiICMEFMGNS--GRIFSGLMTSLFFGAAMA-LLGVVAMFIRRWRQlTFFCN--APFAFYIIYYFFLP 272
Cdd:PRK11551 117 lggALPNLIA----LTSEAVGPRlrGTAVSLMYCGVPFGGALAsVIGVLAAGDAAWRH-IFYVGgvGPLLLVPLLMRWLP 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   273 ESPRwsvsvgkWADAKKQLKKIAKMngksnvdVDELVdsmknhqnaAEEKETkrshnVTDLFKTPNLrrKTLIVTYI--- 349
Cdd:PRK11551 192 ESRA-------FAQAAGAGKQRAPV-------LRALF---------GEGRAT-----ATLLLWISYF--FTLIVLYFlln 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   350 WVMNAIIYNGLTlnvsnlPVDDYW---SFIINGAVelpGYFVVWPLLQcAGRRWTLAATMIVCGIGCVSAMFMPDGYPWL 426
Cdd:PRK11551 242 WLPSLLVGQGLS------RSQAGLvqiAFNIGGAL---GSLLIGALMD-RLRPRRVVLLIYAGILASLAALAAAPSFAGM 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   427 VASASFIGKFGVGsGFAVIYIFAGELYPTVVRAIGMGMSSMVA--GS--GLLLAPHIVNLGK-----IVKILPLLIMGlm 497
Cdd:PRK11551 312 LLAGFAAGLFVVG-GQSVLYALAPLFYPTQVRGTGVGAAVAVGrlGSmaGPLLAGQLLALGRstvgvIGASIPVILVA-- 388

                 ....*..
gi 6650603   498 ALSAGIL 504
Cdd:PRK11551 389 ALAALLL 395
 
Name Accession Description Interval E-value
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
111-509 3.46e-120

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 358.05  E-value: 3.46e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  111 GWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIES 190
Cdd:cd17317   1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  191 FIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFF 270
Cdd:cd17317  81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  271 LPesprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrRKTLIVTYIW 350
Cdd:cd17317 161 LP--------------------------------------------------------------------RRTIIVGLIW 172
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  351 VMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVASA 430
Cdd:cd17317 173 FVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTL 252
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6650603  431 SFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTFFLP 509
Cdd:cd17317 253 ALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
17-519 1.01e-118

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 360.49  E-value: 1.01e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603     17 GNYGTYQIVFFFIICLPtSLPSAFSAFNIPFVVGNPPHTCHIPE--------GKEYLRPLTNDTQILSCKQYNETQINVF 88
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALP-IALLAFHFVLIVFLGATPEHHCRLPDaanlssrcELNLTLPRLPDGRPESCLRFMVDQWANP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603     89 RAFTSAPVDTYS-DRISLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRS 167
Cdd:TIGR00898  80 SLLGCEPLKLSDlGLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    168 FFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFI 247
Cdd:TIGR00898 160 LLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    248 RRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADAKKQLKKIAKMNGKSnvdvdeLVDSMKNHQNAAEEKETKRS 327
Cdd:TIGR00898 240 PDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK------LPAEVLSLSLEKDLSSSKKQ 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    328 HNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMI 407
Cdd:TIGR00898 314 YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLL 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    408 VCGIGCVSAMFMPDGYPWLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVK 487
Cdd:TIGR00898 394 LAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWL 473
                         490       500       510
                  ....*....|....*....|....*....|..
gi 6650603    488 ILPLLIMGLMALSAGILTFFLPETLGAPLPMT 519
Cdd:TIGR00898 474 FLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
107-509 3.39e-64

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 213.69  E-value: 3.39e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  107 PCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAK 186
Cdd:cd17374   7 PCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAP 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  187 DIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYII 266
Cdd:cd17374  87 TFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  267 YYFFLPesprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrRKTLIV 346
Cdd:cd17374 167 YSWWLP--------------------------------------------------------------------KRTLIL 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  347 TYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWL 426
Cdd:cd17374 179 SFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTL 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  427 VASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTF 506
Cdd:cd17374 259 RTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLAL 338

                ...
gi 6650603  507 FLP 509
Cdd:cd17374 339 LLP 341
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
107-509 9.37e-59

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 199.23  E-value: 9.37e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  107 PCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAK 186
Cdd:cd17376   7 PCLDGWEYSQDVYLSTIVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSP 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  187 DIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRI-FSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYI 265
Cdd:cd17376  87 SWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRIlFSTLGVCIFYAIGYMLLPLFAYFIRDWRMLLLALTLPGVLCV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  266 IYYFFLPesprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrRKTLI 345
Cdd:cd17376 167 PLWWFIP--------------------------------------------------------------------ITTIM 178
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  346 VTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPW 425
Cdd:cd17376 179 SLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQV 258
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  426 LVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILT 505
Cdd:cd17376 259 LATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLTVLIGILT 338

                ....
gi 6650603  506 FFLP 509
Cdd:cd17376 339 LFLP 342
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
104-509 5.94e-57

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 194.56  E-value: 5.94e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  104 SLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASS 183
Cdd:cd17447   4 PVVPCQNGWVYDHSTFSSTIATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  184 FAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAF 263
Cdd:cd17447  84 FSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAP 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  264 YIIYYFFLPesprwsvsvgkwadakkqlkKIAKMNGksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrrkt 343
Cdd:cd17447 164 GIITWWWVP--------------------KISLCTG-------------------------------------------- 179
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  344 livtYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGY 423
Cdd:cd17447 180 ----IVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEF 255
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  424 PWLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGI 503
Cdd:cd17447 256 TVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVILLDDVWLSLPQVIFCGVALLAGG 335

                ....*.
gi 6650603  504 LTFFLP 509
Cdd:cd17447 336 VAFLLP 341
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
101-509 3.50e-55

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 189.48  E-value: 3.50e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  101 DRISLVPCQNGWDYDnsTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGT 180
Cdd:cd17379   1 SMLPLSPCQDGWVYN--TPRSSIVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  181 ASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAP 260
Cdd:cd17379  79 LMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  261 FAFYIIYYFFLPesprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlr 340
Cdd:cd17379 159 NFLFLLYYWFIP-------------------------------------------------------------------- 170
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  341 RKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMP 420
Cdd:cd17379 171 KHTFILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIP 250
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  421 DGYPWLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIV-NLGKIVKILPLLIMGLMAL 499
Cdd:cd17379 251 PDLHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLyRLAEIWLELPLIVFGVLAL 330
                       410
                ....*....|
gi 6650603  500 SAGILTFFLP 509
Cdd:cd17379 331 VAGGLVLLLP 340
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
104-509 5.62e-55

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 189.19  E-value: 5.62e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  104 SLVPCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASS 183
Cdd:cd17375   4 TRFSCSDGFVYDQSKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  184 FAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAF 263
Cdd:cd17375  84 FTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILSLVTIP 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  264 YIIYYFFLPesprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrRKT 343
Cdd:cd17375 164 FILCCWMLP--------------------------------------------------------------------KRT 175
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  344 LIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGY 423
Cdd:cd17375 176 ITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDY 255
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  424 PWLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGI 503
Cdd:cd17375 256 EVLTIVLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSGI 335

                ....*.
gi 6650603  504 LTFFLP 509
Cdd:cd17375 336 LTLMLP 341
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
107-509 2.32e-54

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 187.24  E-value: 2.32e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  107 PCQNGWDYDNSTYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAK 186
Cdd:cd17446   5 PCTDGWVYDKSEFPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSP 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  187 DIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYII 266
Cdd:cd17446  85 SFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  267 YYFFLPesprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrRKTLIV 346
Cdd:cd17446 165 YSWWFP--------------------------------------------------------------------RITFCL 176
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  347 TYIWVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWL 426
Cdd:cd17446 177 SLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQDLQTV 256
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  427 VASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTF 506
Cdd:cd17446 257 RTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILSGIAAC 336

                ...
gi 6650603  507 FLP 509
Cdd:cd17446 337 FLP 339
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
122-509 2.10e-49

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 174.58  E-value: 2.10e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  122 SLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLA 201
Cdd:cd17377  26 SIVSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVM 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  202 FPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFLPEsprwsvsv 281
Cdd:cd17377 106 NGGMSLVAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLSLFIPG-------- 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  282 gkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrrKTLIVTYIWVMNAIIYNGLT 361
Cdd:cd17377 178 ------------------------------------------------------------RTLILMYVWFVCSLVYYGLT 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  362 LNVSNLPVDDYWSFIINGAVELPGYFVVWPLL--QCAGRRWTLAATMIVCGIGCVSAMFMP---DGYPWLVASA---SFI 433
Cdd:cd17377 198 LNAGDLGGNIYLNLALSGLVELPAYPLCIYLInqKWSGRRRTLAGFLFLGGIACLLVMFVPekkDSGVFAVVNStslSLL 277
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6650603  434 GKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTFFLP 509
Cdd:cd17377 278 GKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSLPFIVFGASGLSAGLLSLLLP 353
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
112-509 3.93e-38

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 143.65  E-value: 3.93e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  112 WDYDNSTYlDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVAD-KFGRRRSFFVILTVLIVCGTASSFAKDIES 190
Cdd:cd17378  11 WEWDGGSK-VSIVSEWGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  191 FIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRR-WRQLTFFCNAPFAFYIIYYF 269
Cdd:cd17378  90 YAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGSsWRVLYFWTSIPALIYCILVY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  270 FLPesprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrRKTLIVTYI 349
Cdd:cd17378 170 LFA--------------------------------------------------------------------RRLLAVMVI 181
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  350 WVMNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVAS 429
Cdd:cd17378 182 GFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQI 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  430 A-SFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTFFL 508
Cdd:cd17378 262 AlELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVAILLLGLFALGL 341

                .
gi 6650603  509 P 509
Cdd:cd17378 342 P 342
Sugar_tr pfam00083
Sugar (and other) transporter;
136-516 5.34e-27

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 113.91  E-value: 5.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    136 WIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIIL---RFFTGLAFPALFQIPFII 212
Cdd:pfam00083  47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLivgRVLVGIGVGGASVLAPMY 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    213 CMEFMGNSGRifsGLMTSLFFgAAMALLGVVAMFI----------RRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVG 282
Cdd:pfam00083 127 ISEIAPKKLR---GALGSLYQ-LAITFGILLAYIFglglnktsnsDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKG 202
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    283 KWADAKKQLKKIakmNGKSNVD--VDELVDSMknhqnaaEEKETKRSHNVTDLFKTPNLRRKTLIVTYIWV------MNA 354
Cdd:pfam00083 203 RLEEAREVLAKL---RGVPDVDreLDEIKDSL-------EAGQEAEKASWKELFSTKTRRQRLLIGVMLQIfqqltgINA 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    355 IIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTL---AATMIVCGIG-CVSAMFMPDGYPW----- 425
Cdd:pfam00083 273 IFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLllgAAGMAICFVIlGIVALLGVSKSDWagiva 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    426 LVASASFIGKFGVGSGfAVIYIFAGELYPTVVRAIGMGMSSMV--AGSGL--LLAPHIVNLGKIVKIlPLLIMGLMALSA 501
Cdd:pfam00083 353 IVFIALFIAFFAMGWG-PVPWVIVSELFPLSVRSKAMALATAAnwLANFLigFLFPIITDAIGLGYT-FFIFAGLLVLFI 430
                         410
                  ....*....|....*
gi 6650603    502 GILTFFLPETLGAPL 516
Cdd:pfam00083 431 IFVFFFVPETKGRTL 445
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
117-513 3.58e-26

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 111.13  E-value: 3.58e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  117 STYLDSLVTEFNLVCDQQAWIEISTTsfyVGSFIGNCLFGYVADKFGRRRSFFvILTVLIVCG-TASSFAKDIESFIILR 195
Cdd:cd17358  26 PSLMSDNSLSLPLTVAQFSWFGSLLT---LGALIGALLSGKLADRIGRKRTLL-ISAIPCILGwLLIAFAKDVWMLYLGR 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  196 FFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRrWRQLTFFCNAPFAFYIIYYFFLPESP 275
Cdd:cd17358 102 FLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP-WRTLALIGAIPPVVFLILLFFIPESP 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  276 RWSVSVGKWADAKKQLKkiaKMNGKSNVDVDELVDSMknHQNAAEEKETKRShnVTDLFKTPNLRRKTLIVTYIWVM--- 352
Cdd:cd17358 181 RWLAKKGREEEAEKSLQ---FLRGKDADISKEAAEIQ--EELAELEKEAKES--SFSDLFQRKYLKPLVIGLGLMLFqql 253
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  353 ---NAIIYNGLT-LNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGC--VSAMF-------M 419
Cdd:cd17358 254 sgiNAVIFYASSiFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLlaLGLYFylqehgaL 333
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  420 PDGYPWL--VASASFIGKFGVGSGfAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLaphivnlgkIVKILPLLIM--- 494
Cdd:cd17358 334 LSSVSWLplVGLVIYIISFSIGLG-PLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFI---------VTKTFPFLTLawg 403
                       410       420
                ....*....|....*....|....*...
gi 6650603  495 --GLMALSAGI-------LTFFLPETLG 513
Cdd:cd17358 404 asGTFWIFAGIcglalvfVLLFVPETKG 431
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
120-506 1.29e-24

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 105.38  E-value: 1.29e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  120 LDSLVTEFNLVcDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTG 199
Cdd:cd17316  22 APVLAAEFSLG-LSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQG 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  200 LAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRR-------WRqLTFFCNAPFAFYIIYyfflp 272
Cdd:cd17316 101 IGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgdwgWR-ILFLIGALPALLALL----- 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  273 esprwsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnLRRKTLIVTYIWVM 352
Cdd:cd17316 175 ------------------------------------------------------------------LRRRTLLLILLWFF 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  353 NAIIYNGLTLNVSNL--------PVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYP 424
Cdd:cd17316 189 ISFGYYGLTTFLPTYlqtvlglsPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSP 268
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  425 WLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNL---GKIVKILPLLIMGLMALSA 501
Cdd:cd17316 269 TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALllaSTGGTGVPALILALLAIVA 348

                ....*
gi 6650603  502 GILTF 506
Cdd:cd17316 349 LIVAL 353
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
135-472 1.48e-22

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 99.28  E-value: 1.48e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  135 AWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICM 214
Cdd:COG2814  45 AQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIA 124
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  215 EFM--GNSGRIFSGLMTSLFFGAAMA-LLGVVAMFIRRWRqLTFFCNAPFAF--YIIYYFFLPESPRwsvsvgkwadakk 289
Cdd:COG2814 125 DLVppERRGRALGLLGAGLGLGPALGpLLGGLLADLFGWR-WVFLVNAVLALlaLLLLLRLLPESRP------------- 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  290 qlkkiakmngksnvdvdelvdsmknhqnaaeEKETKRSHNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTL---NVSN 366
Cdd:COG2814 191 -------------------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLylqEVLG 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  367 LPVDDY-WSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCvsAMFMPDGYPWLVASASFIGKFGVGSGFAVI 445
Cdd:COG2814 240 LSASAAgLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL--LLLALAGSLWLLLLALFLLGFGFGLLFPLL 317
                       330       340
                ....*....|....*....|....*..
gi 6650603  446 YIFAGELYPTVVRAIGMGMSSMVAGSG 472
Cdd:COG2814 318 QALVAELAPPEARGRASGLYNSAFFLG 344
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
139-513 1.69e-21

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 97.33  E-value: 1.69e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  139 ISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCG---TASSFAKDIESFIILRFFTGLAFPALFQipfIICME 215
Cdd:cd17357  53 LIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSllmFLSKSAKSPELLIFGRFLVGIACGLSTG---FVPMY 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  216 FMGNSGRIFSGLMtSLFFGAAMALLGVVAMFI---------RRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSV-GKWA 285
Cdd:cd17357 130 LQEISPSELRGAL-GSLTQIGVTLGILLGQVFglpsvlgteTLWPYLLFFPGIPALLQLAALPFFPESPKFLLISkGDEE 208
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  286 DAKKQLKKIAKMNGKSNVDVDELVDSMKNHQNAAEEKetkrshnVTDLFKTPNLRRKTLIVTYIWVM------NAIIYNG 359
Cdd:cd17357 209 EAEKSLKFLRGIEDDVDQELEEIKKESEQMGDQKQVS-------LMQLLRDPSLRLPLLLVLVVSASqqfsgiNAIFFYS 281
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  360 --LTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTL---AATMIVCGIGCVSAMFMPDGYPWL-----VAS 429
Cdd:cd17357 282 tfIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLlisLSVCAVALLLMSVFLFLSEQNSWMsygciVAI 361
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  430 ASFIGKFGVGSGfAVIYIFAGELYPTVVRAIGMGMSSMVAGSG----LLLAPHIVNLGKIVKILPLLImgLMALSAGILT 505
Cdd:cd17357 362 FLFIFFFAIGLG-PIPWFIGAELFPQAPRSAAQSLGSSVNWTSnfivGMAFPPLQSIGGGFVFIIFAI--PCALFLLYLY 438

                ....*...
gi 6650603  506 FFLPETLG 513
Cdd:cd17357 439 RYLPETKG 446
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
138-519 3.01e-21

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 97.02  E-value: 3.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    138 EISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGT---ASSFAKDIESFIILRFFTGLAFPALFQIPFIICM 214
Cdd:TIGR00879  74 GLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAIlmgLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLS 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    215 EfmgNSGRIFSGLMTSL---------FFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWA 285
Cdd:TIGR00879 154 E---IAPKALRGALTSLyqlaitfgiLVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVE 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    286 DAKKQLKKIAKMNGKsNVDVDELVDSMKNHQNAAEEKETKRSHNVTDLFKTPNLRRKTLIVTYIWV----MNAIIYNGLT 361
Cdd:TIGR00879 231 EARKSLARLRGTSGE-DKELLDELELIDIKRSIEKRSVQPSWGSLFSSTRRIRRRLFLGVVLQWFQqftgINAIMYYSPT 309
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    362 LnVSNLPVDDYWSF---IINGAVELPGYFVVWPLLQCAGRRWTL---AATMIVC--GIGCVSAMFMPDGYPW-----LVA 428
Cdd:TIGR00879 310 I-FENAGVSTDHAFlvsIIVGAVNFAFTFVAIFLVDRFGRRPLLligAAGMAIClfVLGILGASFVTGSSKSsgnvaIVF 388
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    429 SASFIGKFGVGSGfAVIYIFAGELYPTVVRAIGMgmssMVAGSGLLLAPHIVNL-------GKIVKILPLLIMGLMALSA 501
Cdd:TIGR00879 389 ILLFIAFFAMGWG-PVPWVIVSEIFPLSLRPKGI----SIAVAANWLANFIVGFlfptmleSIGVGGVFIFFGGLNVLGL 463
                         410
                  ....*....|....*...
gi 6650603    502 GILTFFLPETLGAPLPMT 519
Cdd:TIGR00879 464 IFVYFFLPETKGRTLEEI 481
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
126-508 3.85e-20

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 92.21  E-value: 3.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  126 EFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPAL 205
Cdd:cd17372  28 EWNLSAWQVALI---TSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGG 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  206 FQIpFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRR---WRQLTFFCNAPFAFYIIYYFFLPESPR--WSVS 280
Cdd:cd17372 105 PQL-ASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPrlgWRWLLAFSSVPSSLLLVFYRWTPKTTLllWVIW 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  281 VGKWADAKKQLKKIAKMNGKSNVDvdelvdSMKNHQNAAEEKETKRSHNVTDlfktpnlrrktlivtyiwvmnaiiyngl 360
Cdd:cd17372 184 FGNAFAYYGVVLLTTELNNSHNVC------GSKSDSDSGESPTEKQCRNSND---------------------------- 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  361 tlnvsnlpvDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIgCVSAMFMPDGyPWLVASASFIGKFGVGS 440
Cdd:cd17372 230 ---------VDYRDVFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCI-FLLLLLICQS-PFILTVLLFGGRACISA 298
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6650603  441 GFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHI-VNLGKIVKILPLLIMGLMALSAGILTFFL 508
Cdd:cd17372 299 AFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIaQVLVHGSQTIALLLFSVVCLVSAICVCLL 367
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
117-511 1.58e-18

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 87.74  E-value: 1.58e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  117 STYLDSLVTEFNLVcdqQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSffVILTVLI--VCGTASSFAKDIESFIIL 194
Cdd:cd17371  19 GLVLPALIAEFGLD---EAEAGLLGTVTLAGGAIGGILGGILADRFGRVRV--LVITILLfaVFTLLCGFAQNYWQLLIL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  195 RFFTGLAFPALfqipFIICMEFMGNS------GRIFSGLMTSLFFGAAMA-----LLGVVAMFIRRWRQLTFFCNAPFAF 263
Cdd:cd17371  94 RALAGLGFGGE----WAAGAALMAEYvparhrGKALGYVQSGWAVGWLLAtllaaLLFPLLPPEIAWRVLFLLGALPALL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  264 YIIYYFFLPESPRWsvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhQNAAEEKETKRSHNVTDLFKTPNLRRKT 343
Cdd:cd17371 170 VLFIRRFVKEPPQW--------------------------------------QAARAARRHFADRPSLRELFSPPLLRTT 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  344 LIVTYIWVMNAIIYNGLT----------LNVSNLPVDDYWSFIINGAveLPGYFVVWPLLQCAGRRWTLAATMIVCGIGC 413
Cdd:cd17371 212 LLASLLATGALGGYYGITtwlpsyltgeRGLSFEGSAGYLVVTILGG--FLGYLAGGFLADRIGRRNNFALFALGSAISI 289
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  414 VSAMFMPDGyPWLVASASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMG----MSSMVAGSGLLLAPHIVNLGKIVkiL 489
Cdd:cd17371 290 LLYFFLPLS-PTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGfcynVGRIIGALFPFLVGFLATSGSLG--T 366
                       410       420
                ....*....|....*....|...
gi 6650603  490 PLLIMGLMALSAG-ILTFFLPET 511
Cdd:cd17371 367 AIAVFAAVYYIAGlVLALLLPET 389
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
106-270 1.43e-16

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 81.36  E-value: 1.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  106 VPCQNGWDYDNSTYLDS-LVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSF 184
Cdd:cd17443   6 VLCTGGWPFSAAAGLGSnLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVAL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  185 AKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFY 264
Cdd:cd17443  86 SASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTLPLLLL 165

                ....*.
gi 6650603  265 IIYYFF 270
Cdd:cd17443 166 LLYWCF 171
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
117-508 1.64e-16

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 81.32  E-value: 1.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  117 STYLDSLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRF 196
Cdd:cd06174  16 SPLLPALLQSFGLSASQLGLL---FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  197 FTGLAFPALF-QIPFIICMEFMGNSGRIFSGLMTSlFFGAAMALLGVVAMFI-----RRWRQLTFFCNAPFAFYIIYYFF 270
Cdd:cd06174  93 LLGLGSGLIDpAVLALIADLFPERERGRALGLLQA-FGSVGGILGPLLGGILasslgFGWRAVFLIAAALALLAAILLLL 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  271 LPESPRWSvsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnAAEEKETKRSHNVTDLFKTPNLRRKTLIVTYIW 350
Cdd:cd06174 172 VVPDPPES---------------------------------------ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAI 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  351 VMNAIIYNGLTLNVSNLPVDDY--------WSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDG 422
Cdd:cd06174 213 FLVNLAYYSFSTLLPLFLLDLGglsvavagLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS 292
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  423 YPWLVASASFIGkFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVN-LGKIVKILPLLIMGLMALSA 501
Cdd:cd06174 293 LLLLLLLLLLLG-FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGfLLAATFGLTGAFLVLAVLLL 371

                ....*..
gi 6650603  502 GILTFFL 508
Cdd:cd06174 372 LAAILLL 378
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
108-267 4.56e-16

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 79.82  E-value: 4.56e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  108 CQNGWDYDNSTYLDS-LVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAK 186
Cdd:cd17445   8 CDAGWNYTGLPGLTNnIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  187 DIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLF-FGAAMALLGvVAMFIRRWRQLTFFCNAPFAFYI 265
Cdd:cd17445  88 SPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTmVGGHFLLLG-LALGCGSWRVLQGTITAPLSLFL 166

                ..
gi 6650603  266 IY 267
Cdd:cd17445 167 CY 168
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
122-509 1.20e-15

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 78.70  E-value: 1.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  122 SLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLA 201
Cdd:cd17441  24 QLHCEWRLPSWQVALL---TSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFG 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  202 FPALFQiPFIICMEFMGNSGRIFSGLMTSLF--FGAAM-ALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFLPESPRWs 278
Cdd:cd17441 101 IGGVPQ-SVTLYAEFLPMKSRAKCILLIEVFwaLGTVFeVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARY- 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  279 vsvgkwadakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrRKTLIVTYIWVMNAIIYN 358
Cdd:cd17441 179 --------------------------------------------------------------WTTILLWFIWFSNAFSYY 196
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  359 GLTLNVSNL--------------------------PVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIg 412
Cdd:cd17441 197 GLVLLTTELfqagdvcsgssgkkvegkcsleceylTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMALCFFVFSF- 275
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  413 CVSAMFMPDGYPWLVASAsFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHI--VNLGKIVkILP 490
Cdd:cd17441 276 CTLLLFSCVGRFSLTVLL-FIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIaqVMLESSV-YLT 353
                       410
                ....*....|....*....
gi 6650603  491 LLIMGLMALSAGILTFFLP 509
Cdd:cd17441 354 LSVYSGCCLLAAIASCFLP 372
MFS_1 pfam07690
Major Facilitator Superfamily;
116-477 3.19e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 77.07  E-value: 3.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    116 NSTYLDSLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILR 195
Cdd:pfam07690  16 GPALPLLLAEDLGISPTEIGLL---LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLR 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    196 FFTGLAFPALFQIPFIICMEFMGNS--GRIFSGLMTSLFFGAA-MALLGVVAMFIRRWRqLTFFCNAPFAFYIIYYFFLP 272
Cdd:pfam07690  93 VLQGLGAGALFPAALALIADWFPPEerGRALGLVSAGFGLGAAlGPLLGGLLASLFGWR-AAFLILAILSLLAAVLLLLP 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    273 ESPRWSVsvgkwadakkqlkkiakmngksnvdvdelvdsmknHQNAAEEKETKRSHNVTDLFKTPNLRRKTLIVTYIWVM 352
Cdd:pfam07690 172 RPPPESK-----------------------------------RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    353 NAIIYNG-LTLNVSNL-PVDDYWSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMP--DGYPWLVA 428
Cdd:pfam07690 217 FGLLTYLpLYQEVLGLsALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSltLSSLWLLL 296
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 6650603    429 SASFIGkFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAP 477
Cdd:pfam07690 297 ALLLLG-FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
141-509 1.26e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 75.68  E-value: 1.26e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  141 TTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNS 220
Cdd:COG2271  51 ASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK 130
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  221 --GRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFlpesprwsvsvgkwadakkqlkkiakmn 298
Cdd:COG2271 131 erGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF---------------------------- 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  299 gksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrrktLIVTYIWVMNAIIYNGLTLNVSNLPVDDY------ 372
Cdd:COG2271 183 ---------------------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVRglslaq 217
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  373 --WSFIINGAVELPGYFVVWPLLQCAGRR--WTLAATMIVCGIGCVSAMFMPDgyPWLVASASFIGKFGVGSGFAVIYIF 448
Cdd:COG2271 218 agLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPS--PALAIALLFLAGFGLGGAFGLLWAL 295
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6650603  449 AGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVnlGKIVKI----LPLLIMGLMALSAGILTFFLP 509
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLV--GYLLDAtgyqAAFLLLAALALLAALLALLLL 358
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
117-510 1.32e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 72.61  E-value: 1.32e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  117 STYLDSLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRF 196
Cdd:COG2223  25 SVLAPPLAEEFGLSAAQLGLL---FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGL 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  197 FTGLAFPALFQIPfiicmefMGNSGRIFS----GLMTSLF---FGAAMALLGVVAMFIRR---WRQLTFFCNAPFAFY-I 265
Cdd:COG2223 102 LLGIGGGGSFAVG-------IALVSKWFPpdrrGLALGLAaggGNLGAAVAAFLAPLLIAafgWRNAFLILGILLLVVaV 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  266 IYYFFLPESPRwsvsvGKWADAKKQLKKIAKMngksnvdvdelvdsmknhqnaaeeketkrshnvtdlFKTPnlrrKTLI 345
Cdd:COG2223 175 LAWLFLRDPPA-----GAAAAAKASLRDQLEA------------------------------------LRDP----RFWL 209
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  346 VTYIWVMNAIIYNGLTLNVSNLPVDDY-----WSFIINGAVELPGYF--VVWPLL-QCAGRRWTLAATMIVCGIGCVSAM 417
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFglsaaTAGLLAALFALLGALgrPLGGWLsDRIGGRRVLLIVFALMALGLLLLA 289
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  418 FMPDGYPWLVASASFIGkFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIvnLGKIVKI-----LPLL 492
Cdd:COG2223 290 LALGSLWLFLVLFLLLG-LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLL--FGALLDAtgsytAAFL 366
                       410
                ....*....|....*...
gi 6650603  493 IMGLMALSAGILTFFLPE 510
Cdd:COG2223 367 VFAVLALVALVLTLLLYR 384
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
133-468 6.65e-13

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 70.83  E-value: 6.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  133 QQAWiEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIIL---RFFTGLafpalfqip 209
Cdd:cd17431  49 TTLW-SLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLilgRFIIGL--------- 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  210 fiicmefmgnsgriFSGLMTSLF---------------FGAAMALLGVVAMFIR-------------RWRQLTFFCNAPF 261
Cdd:cd17431 119 --------------YCGLTTGLVpmyigeisptalrgaLGTLHQLGIVVGILISqifglefilgteeLWPLLLGFTIVPA 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  262 AFYIIYYFFLPESPRWSVSVGKW-ADAKKQLKKIakmngKSNVDVDELVDSMKnhqnaAEEKETKRSHNVT--DLFKTPN 338
Cdd:cd17431 185 ILQLALLPFCPESPRYLLINRNEeEEAKSVLKKL-----RGTTDVSEDIQEMK-----EESRQMMREKKVTilELFRSSS 254
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  339 LRRKTLIVTYIWV------MNAIIYNGLTLNVSNLPVDDYWSFIINGAVELPGYFVVWPLLQCAGRRwTL----AATMIV 408
Cdd:cd17431 255 YRQPIIIAIVLQLsqqlsgINAVFYYSTSIFEKAGVQQPVYATIGAGVVNTIFTVVSLFLVERAGRR-TLhligLGGMAI 333
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6650603  409 CGIGCVSAMFMPDGYPW-----LVASASFIGKFGVGSGfAVIYIFAGELYPTVVRAIGMGMSSMV 468
Cdd:cd17431 334 CAILMTIALLLLEGYPWmsyvsIVAIFGFVAFFEIGPG-PIPWFIVAELFSQGPRPAAMAVAGFS 397
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
147-480 8.55e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 70.08  E-value: 8.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    147 GSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSGR-IFS 225
Cdd:TIGR00895  64 GMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRgTAV 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    226 GLMTSLF-FGAAMA-LLGVVAMFIRRWRQLTFFCN-APFAFYIIYYFFLPESPRWSVSvgkwadakKQLKKIAKMNGKSN 302
Cdd:TIGR00895 144 GLMFCGYpIGAAVGgFLAGWLIPVFGWRSLFYVGGiAPLLLLLLLMRFLPESIDFLVS--------KRPETVRRIVNAIA 215
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    303 VDVDELVDSMKNHQNAAEEKETkrshNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFiingavE 382
Cdd:TIGR00895 216 PQMQAEAQSALPEQKSTQGTKR----SVFKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSL------S 285
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    383 LPGYFVVwpLLQCAG--RRWTLAATMIVCGIGCV------SAMFMPDGY-----PWLVASASFIGKFGVGSGFAVIYIFA 449
Cdd:TIGR00895 286 LAATGGA--LFNFGGviGSIIFGWLADRLGPRVTalllllGAVFAVLVGstlfsPTLLLLLGAIAGFFVNGGQSGLYALM 363
                         330       340       350
                  ....*....|....*....|....*....|.
gi 6650603    450 GELYPTVVRAIGMGMSSMVAGSGLLLAPHIV 480
Cdd:TIGR00895 364 ALFYPTAIRATGVGWAIGIGRLGAIIGPILA 394
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
145-372 7.23e-12

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 68.08  E-value: 7.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    145 YVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNS--GR 222
Cdd:TIGR01299 212 YLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEkrGE 291
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    223 IFSGL----MTSLFFGAAMAL-----------LGVVAMFiRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADA 287
Cdd:TIGR01299 292 HLSWLcmfwMIGGIYAAAMAWaiiphygwsfqMGSAYQF-HSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEA 370
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    288 KKQLKKIAKMNGKSNVDVDEL--VDSMKNHQNAAEEKETKRSHNV----------TDLFK---------TPNLRRKTLIV 346
Cdd:TIGR01299 371 WMILKLIHDTNMRAKGHPEKVfsVNHIKTIHQEDELIEIESDTGTwyqrcfvralSEGGGiwgnflrcfNPEVREITIKL 450
                         250       260       270
                  ....*....|....*....|....*....|
gi 6650603    347 TYIWVMNAIIYNGLTL----NVSNLPVDDY 372
Cdd:TIGR01299 451 MGVWFTLSFGYYGLSVwfpdMIKHLQADDY 480
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
117-468 1.25e-11

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 66.44  E-value: 1.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  117 STYLDSLVTEFNLVCDQQAWiEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRF 196
Cdd:cd17315  17 NGALLYIAKDLGFGLSTSLQ-GLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRF 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  197 FTGLAFPAlfqIPFIICMEFMGNSGRIFSGLMTSLF--------FGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYY 268
Cdd:cd17315  96 LLGLGVGL---ASVLVPLYISEIAPAKIRGALGTLNqlmitfgiLLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLM 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  269 FFLPESPRWSVSVGkwadakkqLKKIAKMNGksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrrktlivty 348
Cdd:cd17315 173 FFLPESRALLVGVG--------LQLLQQLTG------------------------------------------------- 195
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  349 iwvMNAIIYNGLTL--NVSNLPVDDYWSFIInGAVELPGYFVVWPLLQCAGRRWTL---AATMIVCGIGCVSAMFMPDGY 423
Cdd:cd17315 196 ---INAVMYYAPTIfkSAGGGTASILASIIV-GVVNLLATLVAIRLVDKVGRRPLLligFAGMAASLLLLAIAFLLPALA 271
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 6650603  424 PW-----LVASASFIGKFGVGSGfAVIYIFAGELYPTVVRAIGMGMSSMV 468
Cdd:cd17315 272 KAagwlaLLGILLYIAAFAMGAG-PVPWLLLSEIFPLRIRGKGMAIATLV 320
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
114-281 1.85e-11

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 65.22  E-value: 1.85e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  114 YDNSTY---LDSLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIES 190
Cdd:COG0477  28 LDFTIVnvaLPSIAADLGASSAQLGWI---VSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPEL 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  191 FIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRR---WRqLTFFCNAPFAFYIIY 267
Cdd:COG0477 105 LIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAalgWR-WIFLINAPLGLLALV 183
                       170
                ....*....|....*
gi 6650603  268 Y-FFLPESPRWSVSV 281
Cdd:COG0477 184 LrLRLPESRGLLLAL 198
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
134-508 2.24e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 65.68  E-value: 2.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  134 QAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIIC 213
Cdd:cd17325  30 VAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALI 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  214 MEFM--GNSGRIFSGLMTSLFFG-AAMALLGVVAMFIRRWRQLTFFCNAPFAF-YIIYYFFLPESPRwsvsvgkwadakk 289
Cdd:cd17325 110 ADIAppEERGRAMGIFSSAIGLGfLIGPLLGGLLADALGYRAPFLVCAALALLaLVLALLLLPEPRP------------- 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  290 qlkkiakmngksnvdvdelvdsmknhqnaAEEKETKRSHNVTDLFKTPnLRRKTLIVTYiwVMNAIIYNGLTLNVSNLPV 369
Cdd:cd17325 177 -----------------------------PPNKRAVSAARLRSGLRLL-LRDRRLLALF--LAIFVLAFAFGALEPFLPL 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  370 --------DDYWSFIINGAVELPGYFVVWPLLQCA---GRRWTLAATMIVCGIgCVSAMFMPDGYPWLVASASFIGkFGV 438
Cdd:cd17325 225 yaaelgglSPAQIGLLFGAQGLASALSQPPAGKLSdriGRKPLILIGLLLSAV-ALLLLPLATSFWLLLLLLALLG-LGL 302
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6650603  439 GSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIvnLGKIVKIL----PLLIMGLMALSAGILTFFL 508
Cdd:cd17325 303 GLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL--GGFLYDAFgfatPFLAAAALLLLAAVLFLLL 374
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
146-516 2.44e-11

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 66.29  E-value: 2.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    146 VGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTAS--SFAKDIESFIILRFF----TGLAFPALFQIPFIICMEFMGN 219
Cdd:TIGR00887  67 IGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASglSPGSSPKSVMATLCFwrfwLGVGIGGDYPLSAIITSEFATK 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    220 SGRifsGLMTSLFF--------GAAMALLGVVAMFIRR---------------------WRQLTFFCNAPFAfyIIYYFF 270
Cdd:TIGR00887 147 KWR---GAMMAAVFamqgfgilAGAIVALIVLAGFKHSleaaadeasctgscvpavdymWRILIGFGAVPAL--LALYFR 221
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    271 L--PESPRWSVSVGKwaDAKKQLKKIAK-MNGKSNVDVDELvdsmknhQNAAEEKETKRShNVTDLFKTPNLRR--KTLI 345
Cdd:TIGR00887 222 LtiPETPRYTADVAK--DVEQAASDMSAvLQVKIEAEPDEV-------EKASTAVEVPKA-SWSDFFTHFFKWRhgKHLL 291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    346 VTYI-WVMNAIIYNGLTLNVSNLPVDDYWS-------------------FIINGAVELPGYFVVWPLLQCAGRRWTLAAt 405
Cdd:TIGR00887 292 GTAGsWFLLDIAFYGVNLNQKVILSAIGYSppaatnnayeelyktavgnLIIALAGTVPGYWVTVFLVDIIGRKPIQLM- 370
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    406 mivcGIGCVSAMFMPDGYPW----------LVASASFIGKFGVGsgfAVIYIFAGELYPTVVRAIGMGMS-------SMV 468
Cdd:TIGR00887 371 ----GFFILTVLFFVLGFAYnhlsthgflaIYVLAQFFANFGPN---ATTFIVPGEVFPTRYRSTAHGISaasgkagAII 443
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6650603    469 AGSGLLLAPHIVNLGKIVKILP-----LLIMGLMALSAGILTFFLPETLGAPL 516
Cdd:TIGR00887 444 GQFGFLYLAQHGDPTKGYPTGIwmghvLEIFALFMFLGILFTLLIPETKGKSL 496
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
145-362 3.13e-11

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 65.71  E-value: 3.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  145 YVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNS--GR 222
Cdd:cd17438  44 YLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREkrGE 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  223 IFSGL----MTSLFFGAAMAL-----------LGVVAMFiRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADA 287
Cdd:cd17438 124 HLSWLcmfwMIGGLYASAMAWsiiphygwgfsMGTNYHF-HSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDEA 202
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6650603  288 KKQLKKIAKMNGKSnvdvdelvdsmknhqNAAEEKetkrshnvtdLFKTPNLRRK-TLIVTYIWVMNAIIYNGLTL 362
Cdd:cd17438 203 WMILKNIHDTNMRA---------------KGTPEK----------VFTVSNIKRKnTLFLAVVWFTMAFSYYGLTV 253
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
145-511 3.25e-11

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 65.70  E-value: 3.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  145 YVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNS--GR 222
Cdd:cd17440  44 YLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREkrGE 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  223 IFSGL----MTSLFFGAAMAL-----------LGVVAMFiRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADA 287
Cdd:cd17440 124 HLSWLcmfwMIGGIYASAMAWaiiphygwsfsMGSAYQF-HSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEA 202
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  288 KKQLKKIAKMNGKSNVDVDEL--VDSMKNHQ-----------------------NAAEEKETKRSHNVTDLFKTPNLRRK 342
Cdd:cd17440 203 WMILKQIHDTNMRARGQPEKVftVNRIKKDNtikltivwltlsfgyyglsvwfpDVIKHLQFKSVTFEDSLFKSCFFEDV 282
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  343 TLIVTYI---WVMNAIIYN----------GLTLNVS--------NLPVDD----YWSFIIN--GAVE-LPGYFVVWPLLQ 394
Cdd:cd17440 283 TSVNTYFrncTFIETVFYNtdledykfidSDFINCTffhnktgcQITFDDdysaYWIYFVNflGTLAvLPGNIVSALLMD 362
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  395 CAGRRWTLAATMIVCGIGCVsamfmpdgYPWLVASAS-FIGKFGVGSGFAV-----IYIFAGELYPTVVRAIGMGMSSMV 468
Cdd:cd17440 363 RIGRLTMLGGSMVLSGISCF--------FLWFGTSESmMIGMLCLYNGLTIsawnsLDVVTVELYPTDRRATGFGFLNAL 434
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 6650603  469 AGSGLLLAPHIV-NLGKIVKILPLLIMGLMALSAGILTFFLPET 511
Cdd:cd17440 435 CKAAAVLGNLIFgSLVGITKAIPILLASTVLVCGGLVGLRLPDT 478
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
112-273 4.48e-11

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 64.49  E-value: 4.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  112 WDYDNSTYL-DSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIES 190
Cdd:cd17444  12 RDYRIRAGLvQNIVSKWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTM 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  191 FIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFF 270
Cdd:cd17444  92 FSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICPFLLMLSYWCI 171

                ...
gi 6650603  271 LPE 273
Cdd:cd17444 172 FPK 174
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
112-274 9.57e-11

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 63.69  E-value: 9.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  112 WDYDNSTYL-DSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIES 190
Cdd:cd17373   1 WDYGIRAGLvQNAVSKWDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  191 FIILRFFTGLAFPALFQIPFIICMEFMGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFF 270
Cdd:cd17373  81 FSTLRFLEGFCLAGIILTLYLLRLELCDPGKRLMITMVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWSI 160

                ....
gi 6650603  271 LPES 274
Cdd:cd17373 161 FPKN 164
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
144-513 2.28e-10

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 63.02  E-value: 2.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  144 FYVGSFIGNCLFGYVADKFGRRRSF-----FVILTVLIvCGTaSSFAKDIESFIILRFFTGL-AFPALFQIPFiicmeFM 217
Cdd:cd17432  59 FPLGGLFGSLLVGPLVIRLGRKGTLllnniFAIVAAIL-MGL-SKIAKSFEMIIVGRFLVGInAGISLNVVPM-----YL 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  218 GNSG----RIFSGLMTSLF--FGAAMA-LLGVVAMFIR--RWRQLTFFCNAPFAFYIIYYFFLPESPRWS-VSVGKWADA 287
Cdd:cd17432 132 GESApknlRGAVGLVPAIFitLGILLGqVLGLRELLGNeeGWPLLLALTGVPALLQLLTLPFFPESPRYLlIEKGDEEAA 211
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  288 KKQLKkiaKMNGKSnvDVDELVDSMKNHQNAAEEKETKRshnVTDLFKTPNLRRK--TLIVTY----------IWVMNAI 355
Cdd:cd17432 212 RKALQ---RLRGKE--DVDDEMEEMLEEQRAEKGVGTVS---VLELFRDRSVRWQliSIIVLMagqqlcginaIYFYADS 283
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  356 IYNGLTLNVSNLPvddyWSFIINGAVELPGYFVVWPLLQCAGRRWTLA---ATMIVCGIGCVSAMFMPDGYPWL-----V 427
Cdd:cd17432 284 IFLEAGIPEDKIQ----YVTVGTGACEVLATITCVLVIERLGRRPLLIggfGLMAVWCAVLTVALSLQNTVSWMpylsiV 359
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  428 ASASFIGKFGVGSGfAVIYIFAGELYPTVVRAIGMgmssMVAGSGLLLAPHIVNLgkivkILPLLIMGLMALS----AGI 503
Cdd:cd17432 360 CIFAYIASFGIGPA-GVPFILTTEIFDQSSRPAAF----MVAGSLNWLSNFLVGL-----LFPFIQEGLGAYCflvfAVI 429
                       410
                ....*....|....*..
gi 6650603  504 -------LTFFLPETLG 513
Cdd:cd17432 430 clltaiyIFFVLPETKG 446
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
145-362 2.58e-10

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 62.74  E-value: 2.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  145 YVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNS--GR 222
Cdd:cd17439  44 YLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEkrGE 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  223 IFSGL----MTSLFFGAAMAL-----------LGVVAMFiRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADA 287
Cdd:cd17439 124 HLSWLcmfwMIGGIYASAMAWaiiphygwsfqMGSAYQF-HSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEA 202
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6650603  288 KKQLKKIAKMNGKSnvdvdelvdsmKNHqnaaeekeTKRSHNVTDLfktpnLRRKTLIVTYIWVMNAIIYNGLTL 362
Cdd:cd17439 203 WMVLKQVHDTNMRA-----------KGH--------PERVFSVTHI-----KRRITLMMMAVWFTMSFSYYGLTV 253
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
120-283 6.01e-10

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 61.43  E-value: 6.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  120 LDSLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTG 199
Cdd:cd17359  24 LPFLQTDFNLTPFLEGLV---VSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGG 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  200 LAF---------------PALFQIPFIICMEFMgnsgrIFSGLMTSLFFGAAMA-LLGVVAMFIRRWRQLTFFCNAPFAF 263
Cdd:cd17359 101 LAVggasalvpmyiaevaPAEIRGRLVSLNQLM-----IVFGQLLAYIVNYLIAnAGGADWLGAEGWRWMLGLEAIPAIL 175
                       170       180
                ....*....|....*....|
gi 6650603  264 YIIYYFFLPESPRWSVSVGK 283
Cdd:cd17359 176 FLLGMLFIPESPRWLVSKGK 195
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
135-508 1.39e-09

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 59.89  E-value: 1.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  135 AWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQI--PFII 212
Cdd:cd17474  34 AQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLalTLIG 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  213 CMEFMGNSGRIFSGLMTSLFFGAAM--ALLGVVAMFIRRWRQLTFFCNAPFAFyIIYYFFLPESPRwsvsVGKWADAKKQ 290
Cdd:cd17474 114 DLFEGGERAKAMGLYEAALGLGIAVgpLLGGLLAAISWRYPFFLLAALIPVAF-LAILFLLPEPKE----KAKSSSATKL 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  291 LKKIAKmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnLRRKTLIVTYIWVMNAIIYNGLTLNVSNLPVD 370
Cdd:cd17474 189 RDLKKA------------------------------------------LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  371 D--YWSFIINGAVELP-------GYFVVWPLLQCA-GRRWTLAATMIVCGIGCVSAMFMPDgYPWLVASASFIGkFGVGS 440
Cdd:cd17474 227 LlyGISPIIIGLLFAGwsvllalGSLFVGRLLKKRfGARRILVIGLLLYALSLLLLGFVPS-LALLLIAIVLFG-LGLGL 304
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6650603  441 GFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPhiVNLGKIVKIL----PLLIMGLMALSAGILTFFL 508
Cdd:cd17474 305 NLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGP--LLFGLLLEIFglsaPFLVGAAIALAAAVLLALL 374
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
141-509 1.75e-09

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 59.82  E-value: 1.75e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  141 TTSFYVGSFIGNCLFGYVADKFGRRRsffvILTVLIVCGT----ASSFAKDIESFIILRFFTGLAFPALFQiPFIICMEF 216
Cdd:cd17442  42 TTMVFFGYMVFSILLGLLADRYGRWK----ILLLSFVWGAyfslLTSFAPSYIWFVFLRCMVGCGVSGHSQ-GLIIKTEF 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  217 MGNSGRIFSGLMTSLFFGAAMALLGVVAMFIRR---WRQLTFFCNAPFAFYIIYYFFLPESPR-----WSVSVGKWADAK 288
Cdd:cd17442 117 LPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPtlgWRWLIRFASIPGIILIVVFKFIPRTTLqiwviWLGISFAYYGVI 196
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  289 KQLKKIAKMNGKSNVDVDELvdsmkNHQNAAEEKETkrshnvtdlfktpnlrrktliVTYIWVMNAiiyngltlnvsnlp 368
Cdd:cd17442 197 LASSELLERNLLCGSDPSDE-----EAGIKHIESES---------------------PCYCHMFNP-------------- 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  369 vDDYWSFIINGAvelpGYFVVWPL----LQCAGRRWTLAATMivcgiGCVSAMFMPDGYpwLVASASFIG-----KFGVG 439
Cdd:cd17442 237 -SDYQTMIISTL----GEIALNPLnilgINFLGRRLSLVITM-----GLTAIFFLLLNI--CTSSAGLTIflfmlRALVS 304
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6650603  440 SGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLgkivkILPLLIMGLMALSA------GILTFFLP 509
Cdd:cd17442 305 ANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQV-----LMSASVLGALCLFSsvcivcAISAFTLP 375
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
145-511 1.80e-09

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 60.20  E-value: 1.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  145 YVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEF--MGNSGR 222
Cdd:cd17363  44 YLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFlaREKRGE 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  223 IFSGL----MTSLFFGAAMAL-----------LGVVAMFiRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADA 287
Cdd:cd17363 124 HLSWLcmfwMIGGLYASAMAWaiiphygwgfsMGTAYQF-HSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEA 202
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  288 KKQLKKIAKMNGKSnvdvdelvdsmKNHQNAA-EEKETKRSHNV------------------------------TDLFKT 336
Cdd:cd17363 203 WMILKQVHDTNMRA-----------KGHPERVfTVSHIKRMNTLflaivwftmsfsyygltvwfpdmikylqfeDSLFEE 271
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  337 PNLRRKTLIVTYI---WVMNAIIYN----------------------GLTLNVSNLPVDDYWSFIIN--GAVE-LPGYFV 388
Cdd:cd17363 272 CYFEDVTSTNTFFencTFINTVFYNtdlfeykfidsrflnstfflkeKCGCHLNDDEENAYLIYLVSflGSLSvLPGNIV 351
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  389 VWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVASASFigkFGVG-SGFAVIYIFAGELYPTVVRAIGMGMSSM 467
Cdd:cd17363 352 SALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIGLQCLF---CGVSiAAWNALDVVTVELYPTDKRATAFGFLNG 428
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*
gi 6650603  468 VAGSGLLLAPHIV-NLGKIVKILPLLIMGLMALSAGILTFFLPET 511
Cdd:cd17363 429 LCKLAAILGNSIFgSFVGITKVIPILLASAALVCGGLLALKLPET 473
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
120-276 1.16e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 57.17  E-value: 1.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  120 LDSLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTG 199
Cdd:cd17324  22 LPDIARDFGVSVAQAGLL---VSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  200 LAFPALFQIPFIICMEFMGNS------GRIFSGLMTSLFFGAAMAllGVVAMFIrRWRqLTFFCNAPFAF--YIIYYFFL 271
Cdd:cd17324  99 LAHGGFWAIAAAYAADLVPPEkrgraiGLVFSGLTLGLVLGRPLG--GLLGQLL-GWR-AAFLAIAVLALlaALLLWRLL 174

                ....*
gi 6650603  272 PESPR 276
Cdd:cd17324 175 PSLPP 179
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
116-479 1.81e-08

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 56.87  E-value: 1.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  116 NSTYLDSLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRR--SFFVILTVLIVCGTAssFAKDIESFII 193
Cdd:cd17327  25 SNAAVMGMKEDLKLVGNQYNWG---NTVFYVGYIIFELPGNLLLQRFPPSKwlSVFIVLWGLLTLLTA--AVKNFGGLIA 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  194 LRFFTGLA----FPALF----------QIPFIICMEFMGNS-GRIFSGLMTSLFFgaamALLGVVAMfiRRWRQLTFFCN 258
Cdd:cd17327 100 LRFFLGLFesgvFPGFIlylgmwykreEQAKRIAFFYAAAGlGSIFGGLLAYGVF----KILGVGGL--AGWRWLFIIEG 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  259 -APFAFYIIYYFFLPESP--RWSVSvgkwadakKQLKKIAkmngksnvdvdelVDSMKNHQNAAEEKETKRSHnVTDLFK 335
Cdd:cd17327 174 lITIIIGLVIFFWLPDNPskAWFLT--------EEEKELA-------------VERLRANQTGKGDQKFKWKQ-IKEAFK 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  336 TPNLRRKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYWSFIIN---GAVELPGYFVVWPLLQCAGRRWTLAATMIVCG-I 411
Cdd:cd17327 232 DPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSvpiGALGAVSLLIAALLSDRFKKRGLFAIFACVLAlV 311
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6650603  412 GCVSAMFMPDgyPWLVASASFIGKFGVGSGFAVIYIFA-GELYPTVVRAIGMGMSSMVAGSGLLLAPHI 479
Cdd:cd17327 312 GSIILLAAPN--PPGAYFAAYILGGGSYAGFPILLSWIsSNCAGYTKRATVLAIMLIFYNVGNIVAPQI 378
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
154-509 3.54e-08

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 55.66  E-value: 3.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  154 LFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALfqipFIICMEFMGNsgrIFSGLMTSLFF 233
Cdd:cd17473  54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGI----MTLATALIGD---YFEGEERAKML 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  234 G---AAMALLGVVAMFIR------RWRqltffcnAPFAFY-------IIYYFFLPESPRwsvsvgkwadakkqlkkiakm 297
Cdd:cd17473 127 GlqsAAMSLGGVVFLLLGgalaeiGWR-------APFLVYllalpvlILVLLFLPEPAR--------------------- 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  298 ngksnvdvdelvdsmknhqnaaeeKETKRSHNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLT---LNVSNLPVDD--- 371
Cdd:cd17473 179 ------------------------KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIqlpFLLQERGGGSaal 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  372 --YWSFIINGAVELPGYFVVWpLLQCAGRRWTLAATMIVCGIGCVSaMFMPDGYPWLVASASFIGkFGVGSGFAVIYIFA 449
Cdd:cd17473 235 igLALAIASLAGAIGALLFGR-LKRRLGKRRLLAIGFALMALGFLL-LALASGLWVVLLGAILAG-LGFGLLLPTLNSWA 311
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6650603  450 GELYPTVVRAIGMGMSSMVAGSGLLLAPHIVNLgkIVKILP-----LLIMGLMALSAGILTFFLP 509
Cdd:cd17473 312 MSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGP--LVNLTGglsgaFLILGVLALVLAIVLLLLR 374
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
146-516 1.10e-07

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 54.50  E-value: 1.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  146 VGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLA--FPALFQIPFIICMEFMGNSGRI 223
Cdd:cd17433  52 LGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLAsgVTSLVVPVYISEIAHPRVRGTL 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  224 FSGLMTSLFFGAamaLLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFLPESPRWSVSVGKWADAKKQLKKIakmngkSNV 303
Cdd:cd17433 132 GSCVQLMVVIGI---MGAYLAGLVLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFL------RGP 202
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  304 DVDELVDSMKNHQNAAEEKETKRshnvTDLFKTPNLRRKTLIVTYIWV------MNAIIYNGLTLNVSNLPVDDYWSFII 377
Cdd:cd17433 203 DQGWEWECIGIEQSFHLEEQSFS----LALLKQPGIYKPLIIGVSLMAfqqltgINAVMFYAETIFEEAKFKDSSVASVI 278
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  378 NGAVELPGYFVVWPLLQCAGRRWTLAATMIVCgigCVSAMfmpdGYPWLVASAS--FIGKFGVGSGfAVIYIFAGELYPT 455
Cdd:cd17433 279 VAAIQVLFTAVAALIMDRAGRKVLLVLSGVVM---VFSTA----AFGWLAVGSMgfFIAGFAVGWG-PIPWLVMSEIFPL 350
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6650603  456 VVRAIGMGMSSMVA-GSGLLLAPHIVNLGKIVKILPLLIM--GLMALSAGILTFFLPETLGAPL 516
Cdd:cd17433 351 HVRGVASGICVLTNwLMAFLVTKEFSSLMEVLSSYGTFWLfsAFCAFSVLFTLFCVPETKGKTL 414
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
144-508 2.49e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 52.95  E-value: 2.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  144 FYVGSFIGnclfGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFpALFQ--IPFIICMEFMGNSG 221
Cdd:COG2807  66 FGLFAPLA----PRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI-AVGNvlLPGLIKRWFPDRVG 140
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  222 RIFSGLMTSLFFGAAMALlGVVAMFIRR--WRQ-LTFFCNAPFAFYIIYYFFLPESPRwsvsvgkwadakkqlkkiakmn 298
Cdd:COG2807 141 LMTGLYTAAMGLGAALAA-GLTVPLAAAlgWRGaLAVWALLALLALLLWLPLLRRRPA---------------------- 197
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  299 gksnvdvdelvdsmknHQNAAEEKETKRShnvtdLFKTPnlrrKTLIVTYIWVMNAIIYNGLtlnVSNLP---VDDYWS- 374
Cdd:COG2807 198 ----------------AAAAAPAAASLRS-----LWRSP----LAWLLTLFFGLQSLLYYAV---VAWLPpilRDAGLSa 249
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  375 ------FIINGAVELPGYFVVWPLLQ-CAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLvaSASFIGkFGVGSGFAVIYI 447
Cdd:COG2807 250 atagllLSLFQLAGIPGSLLVPLLADrLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWL--WAVLLG-LGQGGLFPLALT 326
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6650603  448 FAGELYPTVVRAIgmGMSSMVAGSGLLLA---PHIVnlGKIVKI-----LPLLIMGLMALSAGILTFFL 508
Cdd:COG2807 327 LIGLRARTPAEAA--ALSGMAQSVGYLLAalgPLLV--GALHDAtgswtAALLLLAALAVLMLVAGLLA 391
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
123-504 3.15e-07

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 52.66  E-value: 3.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   123 LVTEFNLVCDQQAWI-EISTTSFYVGSFIGnclfGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGL- 200
Cdd:PRK11551  41 MAQEFGLDVAQMGWAfSAGILGLLPGALLG----GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVg 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   201 ---AFPALFQipfiICMEFMGNS--GRIFSGLMTSLFFGAAMA-LLGVVAMFIRRWRQlTFFCN--APFAFYIIYYFFLP 272
Cdd:PRK11551 117 lggALPNLIA----LTSEAVGPRlrGTAVSLMYCGVPFGGALAsVIGVLAAGDAAWRH-IFYVGgvGPLLLVPLLMRWLP 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   273 ESPRwsvsvgkWADAKKQLKKIAKMngksnvdVDELVdsmknhqnaAEEKETkrshnVTDLFKTPNLrrKTLIVTYI--- 349
Cdd:PRK11551 192 ESRA-------FAQAAGAGKQRAPV-------LRALF---------GEGRAT-----ATLLLWISYF--FTLIVLYFlln 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   350 WVMNAIIYNGLTlnvsnlPVDDYW---SFIINGAVelpGYFVVWPLLQcAGRRWTLAATMIVCGIGCVSAMFMPDGYPWL 426
Cdd:PRK11551 242 WLPSLLVGQGLS------RSQAGLvqiAFNIGGAL---GSLLIGALMD-RLRPRRVVLLIYAGILASLAALAAAPSFAGM 311
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   427 VASASFIGKFGVGsGFAVIYIFAGELYPTVVRAIGMGMSSMVA--GS--GLLLAPHIVNLGK-----IVKILPLLIMGlm 497
Cdd:PRK11551 312 LLAGFAAGLFVVG-GQSVLYALAPLFYPTQVRGTGVGAAVAVGrlGSmaGPLLAGQLLALGRstvgvIGASIPVILVA-- 388

                 ....*..
gi 6650603   498 ALSAGIL 504
Cdd:PRK11551 389 ALAALLL 395
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
397-516 3.70e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 52.12  E-value: 3.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  397 GRRWTLAATMIVCGIGCVSAMFMPdGYPWLVAsASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLA 476
Cdd:COG0477  77 GRKRVLLIGLLLFGLASLLCGLAP-SPELLIA-ARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALG 154
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6650603  477 PhIVNLGKIVKI---LPLLIMGLMALSAGILTFFLPETLGAPL 516
Cdd:COG0477 155 P-LLGGLLVAALgwrWIFLINAPLGLLALVLRLRLPESRGLLL 196
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
145-511 4.01e-07

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 52.28  E-value: 4.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  145 YVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIE------SFIILRFFTGLAFPALFQIPFIICMEFMG 218
Cdd:cd17364  49 LVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTplgvmgWLIFFRFLLGIGIGGDYPLSATIMSEYAN 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  219 NSGRifsGLMTSLFFgaAMALLGVVAmfirrwrqltffcnAPFAFYIIYYFFLPESPrwsvsvgkwADAKKQLKKIAKMn 298
Cdd:cd17364 129 KKRR---GALIAAVF--AMQGFGILA--------------GAIVTLILSAIFEHPLP---------AGTYHHADLVWRI- 179
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  299 gksnvdvdelvdsmknhqnaaeeketkrshnVTDLFKTPNL-----RRKTLIVTYIWVMNAIIYNGLTLNVSNLPVDDYW 373
Cdd:cd17364 180 -------------------------------VLGLGAIPALsvlyfRKHLLGTAGTWFLLDIAFYGQNLFQSTIISAIGF 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  374 SF----------------IINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGI-GCVSAMFM------PDGYPWLVASA 430
Cdd:cd17364 229 SKtmnayqelfniavgqlIIALAGTVPGYWFTVFLIDRIGRKKIQMMGFFGMTIfLLILAGPYdhwkisTIGFFVLYGLT 308
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  431 SFIGKFGVGSgfaVIYIFAGELYPTVVRAIGMGMS-------SMVAGSGLLLAPHIVNLGKIvkilpLLIMGLMALSAGI 503
Cdd:cd17364 309 FFFSNFGPNT---TTFIVPAEVFPARVRSTCHGISaasgkigAIVGSFLFLSLTQNIGVRNV-----LIILAGVALLGII 380

                ....*...
gi 6650603  504 LTFFLPET 511
Cdd:cd17364 381 LTLLFPEE 388
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
154-477 5.84e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.21  E-value: 5.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  154 LFGYVAD----KFGRRRSFFVILTVLIVCGTASSFAKDIES-------FIILRFFTGLAFpALFQIPFIICMEFMGNSGR 222
Cdd:COG2211  65 LIGALSDrtrtRWGRRRPWILIGAIPLALSFVLLFTAPDLSptgkliyALVTYLLLGLAY-TLVNIPYSALGAELTPDYE 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  223 ----------IFSGLMTSLFFGAAMALLGVVAMFIRRWRQLTFFCNAPFA--FYIIYYFFLPESPRwsvsvgkwadakkq 290
Cdd:COG2211 144 ertrlsswrfAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGllAFLLTFFGTKERPV-------------- 209
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  291 lkkiakmngksnvdvdelvdsmknhqnaAEEKETKRSHNVTDLFKTPNLRRKTLIVTYIWVMNAIIYNGLTL---NVSNL 367
Cdd:COG2211 210 ----------------------------PEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYyfkYVLGL 261
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  368 PVDDY-WSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDGYPWLVASASFIGKFGVGSGFAVIY 446
Cdd:COG2211 262 SAALVgLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPW 341
                       330       340       350
                ....*....|....*....|....*....|....*...
gi 6650603  447 IFAGEL-----YPTVVRAIG--MGMSSMVAGSGLLLAP 477
Cdd:COG2211 342 AMLADVvdydeWKTGRRREGlyFGIFTFAIKLGQALAG 379
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
145-247 6.96e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.43  E-value: 6.96e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  145 YVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALfqIPFIICM--EFMGNSGR 222
Cdd:cd17365  44 LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA--MPNAITLvsEYAPARRR 121
                        90       100       110
                ....*....|....*....|....*....|
gi 6650603  223 ifsGLMTSLFF-----GAAMAllGVVAMFI 247
Cdd:cd17365 122 ---SLAVTLMFcgyplGAALG--GFLAAAL 146
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
120-509 7.95e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 51.42  E-value: 7.95e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  120 LDSLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTG 199
Cdd:cd17504  19 LPTIQREFGTSAAAVSWV---LTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQG 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  200 LAFpALFQIPFIICME-FMGNSGRIFSGLMTSLF-FGAAMALL--GVVAMFIrRWRqLTFFCNAPFAfyIIYYFFLPesp 275
Cdd:cd17504  96 IGG-AVFPLAFALVREeFPPERVPVAQGILSATFgIGAGIGLPlgGWIVQHL-GWR-WIFWTAAPVA--VLLAALVP--- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  276 rwsvsvgkwadakkqlkkiakmngksnvdvdeLVDsmknhqnaaeeketkrshnvTDLFKTPNLrRKTLIVTYIWVMNAI 355
Cdd:cd17504 168 --------------------------------LID--------------------LRLLRRRNV-LLANITALLAGFGMF 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  356 IYNGLTLNVSNLPVD-DYWSFIIN-GAVELPGYFVVWPLLQCAGR-------RWTLAATMIVCGIGCVSAMFMPDGyPWL 426
Cdd:cd17504 195 MVFQLLPQLLQLPTPtGFGLGITEaGLLLLPGALVMLIAGPLAGRliarvgpRRVLLIGLVISAVGLLLLALLHSS-LWA 273
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  427 VASASFIGKFGVGSGFAVIYIFAGELYP-----------TVVRAIGMGMSSMVAGSglLLAPHIVNLGKIVKILP----- 490
Cdd:cd17504 274 LVVALLLIGIGLGLAFASLPNIVVESVPpdrtgiatgmnTVLRTIGSAIGPAIAGA--ILTTYTVSITSGGVPTEgayvl 351
                       410       420
                ....*....|....*....|
gi 6650603  491 -LLIMGLMALSAGILTFFLP 509
Cdd:cd17504 352 aFLIGAALALAALLLSLLIP 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
397-515 2.41e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 49.97  E-value: 2.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  397 GRRWTLAATMIVCGIGCVSAMFMPDgYPWLVASASFIGkFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLA 476
Cdd:COG2814  73 GRRRVLLLGLLLFALGSLLCALAPS-LWLLLAARFLQG-LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 6650603  477 PHIVnlGKIVKIL----PLLIMGLMAL-SAGILTFFLPETLGAP 515
Cdd:COG2814 151 PLLG--GLLADLFgwrwVFLVNAVLALlALLLLLRLLPESRPAA 192
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
126-508 2.83e-06

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.49  E-value: 2.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  126 EFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLA---- 201
Cdd:cd17319  32 DLGLSPTQYGLI---ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAeagf 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  202 FPALFqipFIICMEFMGNS-GRIFSGLMTSLFFGAA-MALLGVVAMFIRRWRQLTFFCNAP-FAFYIIYYFFLPESprWS 278
Cdd:cd17319 109 FPGAI---KALAEWFPARErGRATGLFNSGAPLGAAiGPPLSGWLLLLFGWRWAFIIEGLLgLLLAVLWWFYLRQV--WG 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  279 VSVGKWAdakkqlkkiakmngksnvdvdelvdsmknhqnaaeeketkrshnvtdlfktpnlrrktlIVTYIWVMNA---- 354
Cdd:cd17319 184 LALGYFG-----------------------------------------------------------INYALYGLLTwlpt 204
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  355 IIYNGLTLNVSN--LPVDDYWSFIINGAVeLPGYFVVWplLQCAGRRWTLAATMIVCGIGCVSAMFMPDgyPWLVASASF 432
Cdd:cd17319 205 YLKQARGFSLKQvgLLAAIPFLAGAIGMI-LGGRLSDR--LLRGARRLVIIIGLLLAAVGLLLAYLTTS--PVVAVILLS 279
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  433 IGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLAPHIVnlGKIVKI-----LPLLIMGLMALSAGILTFF 507
Cdd:cd17319 280 LAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLI--GYLVDAtgsytAAFLFLAAVALLAALLVLL 357

                .
gi 6650603  508 L 508
Cdd:cd17319 358 L 358
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
135-250 4.73e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.13  E-value: 4.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  135 AWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICM 214
Cdd:cd17489  31 AVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVA 110
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 6650603  215 EFMGNSgRIFSGL-MTSLFFGAAMALLGVVAMFIRRW 250
Cdd:cd17489 111 DIIPPS-RRGEGIgYYGLATTLAMALGPALGLFLYQH 146
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
134-508 5.07e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 48.73  E-value: 5.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  134 QAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGL---AFPALFQIpf 210
Cdd:cd17320  33 ASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLgaaAGSVVARA-- 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  211 IICMEFMGN-SGRIFSGLMTSLFFGAAMA-LLGVVAMFIRRWRqLTFFCNAPFAF--YIIYYFFLPESPrwsvsvgKWAD 286
Cdd:cd17320 111 IVRDLYSGAeLAKIFSLLMMILAIAPALApLLGGLLLLFFGWR-AIFVFLALLGLllLLLVLLFLPETL-------PEEK 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  287 AKKQLKKIAkmngksnvdvdelvdsmknhqnaaeeketkrsHNVTDLFKTPNLRRKTLIvtyIWVMNAIIYNGLT----- 361
Cdd:cd17320 183 RKPLLSSLL--------------------------------RAYKRVLKNRRFLGYALA---LGLSFAGLFAYLAaapfi 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  362 -LNVSNLPVDDY-WSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCV----SAMFMPDGYPWLVASASFIGk 435
Cdd:cd17320 228 yIEQLGLSPAQFgLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALvlllAALLGGLSLWPLVAPLFLIF- 306
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6650603  436 FGVGSGFAVIYIFAGELYPTVVRAIG--MGMSSMVAGSGLLLaphIVNLGKIVKILPL-LIMGLMALSAGILTFFL 508
Cdd:cd17320 307 FGFGLIFPNATSLALEPFPHVAGTASalLGFLQFLIGALAGA---LVGLLPNGTALPMgLLILVLGLLALLLLILL 379
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
120-273 5.17e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 48.73  E-value: 5.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  120 LDSLVTEFNlvCDQQAWIeISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTG 199
Cdd:cd17323  22 LPQIAEDFH--VSEEVAN-LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQG 98
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6650603  200 L-AFPALFQIPFIIC-MEFMGNSGRIFSGLMTSLFFGAAMA-LLGVVAMFIRRWRqLTFFCNAPFAF--YIIYYFFLPE 273
Cdd:cd17323  99 FfGSSPLAIGAGTIAdLFTPEERGKAMGVYSLGPLLGPALGpIIGGFITQSLGWR-WIFWFLAIISGfcLILIFLFLPI 176
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
137-274 5.71e-06

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 48.92  E-value: 5.71e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    137 IEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEF 216
Cdd:TIGR00710  42 VQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDI 121
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6650603    217 MGN--SGRIFSGLMTSLFFGAAMALL--GVVAMFIrRWRQL-TFFCNAPFAFYIIYYFFLPES 274
Cdd:TIGR00710 122 YPGeeLSRIYSILMPVLALAPAVAPLlgGYILVWL-SWHAIfAFLSLAGILLSALIFFILPET 183
MFS_1 pfam07690
Major Facilitator Superfamily;
373-510 1.37e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.41  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    373 WSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPdGYPWLVASASFIGkFGVGSGFAVIYIFAGEL 452
Cdd:pfam07690  36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS-SLWLLLVLRVLQG-LGAGALFPAALALIADW 113
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6650603    453 YPTVVRAIGMGMSSMVAGSGLLLAPHIVnlGKIVKIL----PLLIMGLMALSAGILTFFLPE 510
Cdd:pfam07690 114 FPPEERGRALGLVSAGFGLGAALGPLLG--GLLASLFgwraAFLILAILSLLAAVLLLLPRP 173
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
373-510 1.98e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 1.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  373 WSFIINGAVELPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPDgyPWLVASASFIGKFGVGSGFAVIYIFAGEL 452
Cdd:cd06174  35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS--FWLLLLGRFLLGLGSGLIDPAVLALIADL 112
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6650603  453 YP----TVVRAIGMGMSSMVAGSGLLLAPHIVNLGKIVKILPLLIMGLMALSAGILTFFLPE 510
Cdd:cd06174 113 FPererGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVP 174
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
141-251 2.22e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.80  E-value: 2.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  141 TTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKD-----IESFIILRFFTGLAFPALFQ-IPFIICM 214
Cdd:COG2223 247 AALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGslwlfLVLFLLLGLALGGGNGAVFAlVPDIFPT 326
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6650603  215 EFMG-NSGRIFS-----GLMTSLFFG----------------AAMALLGVVAMFIRRWR 251
Cdd:COG2223 327 KNAGaVYGLVGAagglgGFLGPLLFGalldatgsytaaflvfAVLALVALVLTLLLYRR 385
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
133-294 3.36e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 46.47  E-value: 3.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  133 QQAWIeisTTSFYVGSFIGNCLFGYVADKFGrRRSFFVILTVL-----IVCGTassfAKDIESFIILRFFTGLAFPALfQ 207
Cdd:cd06179  33 NSTWI---STAWSLAQAVLGPIVGRLSDLFG-RRWFFIGGNLLgvvgsIVAGT----AKSVNMLIGGQALIGIGAGTQ-G 103
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  208 IPFIICMEFMGNSGRIF-SGLMTSL-FFGAAMALLGVVAMFIR-----RWrqlTFFCNAPF---AFYIIYYFFLPESPRW 277
Cdd:cd06179 104 LGAAVASELVPNKYRGLvQGVVNLVaSPGSALGPLIAGALVEAnaagwRW---IFYINAIFnalALILLFFFYHPPPRPQ 180
                       170
                ....*....|....*..
gi 6650603  278 SVSVGKWadakKQLKKI 294
Cdd:cd06179 181 LHGSSTR----QKLKRL 193
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
135-243 3.53e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 46.01  E-value: 3.53e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  135 AWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFqipfiICM 214
Cdd:cd17477  31 ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLF-----VVS 105
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6650603  215 E-------FMGNSGRIFS--GLMTSLFFGAAMALLGVV 243
Cdd:cd17477 106 EswlnalaTNENRGRVLGlySTVLGLGFALGPLLLALV 143
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
146-238 5.89e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 45.68  E-value: 5.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  146 VGSFIGNCLFGYVADKFGRRRSFFVILTVLIV-CGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMG------ 218
Cdd:cd17353 260 IFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVaMFLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGtknagt 339
                        90       100
                ....*....|....*....|
gi 6650603  219 NSGRIFSGLMTSLFFGAAMA 238
Cdd:cd17353 340 NYGLLYTAKGVGGLIGPIIA 359
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
134-238 6.08e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 45.35  E-value: 6.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  134 QAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIIC 213
Cdd:COG2814 242 ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALV 321
                        90       100
                ....*....|....*....|....*..
gi 6650603  214 MEFMGNS--GRIFSGLMTSLFFGAAMA 238
Cdd:COG2814 322 AELAPPEarGRASGLYNSAFFLGGPLA 348
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
142-508 6.29e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 6.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  142 TSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFpALFQI---PFIICMEFMG 218
Cdd:COG0738  50 FAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGL-GLLDVaanPYVAALGPET 128
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  219 NSGRI------FS-GLMTSLFFGAAMALLGVVAmfirRWRQLTFFCNAPFAFYIIYYFFLPeSPRWSvsvgkwadakkql 291
Cdd:COG0738 129 AASRLnllhafFSlGALLGPLLGGLLILLGLSL----SWHLPYLILAVLLLLLALLFLRSK-LPEIE------------- 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  292 kkiakmngksnvdvdelvdsmknhqnAAEEKETKRSHNVTDLFKTPNLRRKTLIV---------TYIWVMN-AIIYNGLT 361
Cdd:COG0738 191 --------------------------EEEEEAAGSAASLKSLLKNPRLLLGGLAIflyvgaegaIGDWLPLyLKDVLGLS 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  362 LNVSNLPVDDYWSFIingaveLPGYFVVWPLLQCAGRRWTLAATMIVCGIGCVSAMFMPdGYPWLVASASFIGkFGVGSG 441
Cdd:COG0738 245 EATAALGLSLFWGGM------TIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP-GPWLALIGLALVG-LGLSLM 316
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6650603  442 FAVIYIFAGELYPTvVRAIGMGMSSMVAGSGLLLAPhivnlgkivkilplLIMGLMALSAGILTFFL 508
Cdd:COG0738 317 FPTIFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGP--------------PLIGFLADAFGLRAAFL 368
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
117-246 9.58e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 44.87  E-value: 9.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  117 STYLDSLVTEFNLVCDQQAWIeisTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRF 196
Cdd:cd17503  16 NVALPTIMGDLGASLDTVQWV---ITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRI 92
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6650603  197 FTGLAFPALFQIPFIICMEFMGNSGRifsglmtslffGAAMALLGVVAMF 246
Cdd:cd17503  93 LQGFGGGVLIPLAQTILLRIYPPEKR-----------GAAMGLVGLVILL 131
xylE PRK10077
D-xylose transporter XylE; Provisional
135-320 3.28e-04

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 43.53  E-value: 3.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   135 AWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKdiesfiiLRFFT----GLAFPALFQIPF 210
Cdd:PRK10077  55 SLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAAVLFFISALGSAWPE-------FGFTSigpdNTGYVPEFVIYR 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603   211 II-----------CMEFMGN------SGRIFSGLMTSLFFGaaMALLGVVAMFIRR-----------WRQLtFFCNA-PF 261
Cdd:PRK10077 128 IIggigvglasmlSPMYIAEiapahiRGKLVSFNQFAIIFG--QLVVYFVNYFIARsgdaswlntdgWRYM-FASEAiPA 204
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6650603   262 AFYIIYYFFLPESPRWSVSVGKWADAKKQLKKIakmNGKSNVD--VDELVDSMKNHQNAAE 320
Cdd:PRK10077 205 LLFLMLLYFVPETPRYLMSRGKQEQAEGILRKI---MGNTLATqaLQEIKHSLDHGRKTGG 262
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
117-277 3.36e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 43.03  E-value: 3.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  117 STYLDSLVTEFNLVCDQQAWIEISTTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRF 196
Cdd:cd17360  17 SGALLYIKDDLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  197 FTGLAFP-ALFQIPFIIC---------MEFMGNSGRIFSGLMTSLFFGAAMALLGVvamfirRWRQLTFFCNAPFAFYII 266
Cdd:cd17360  97 LVGLGVGiASMTVPLYIAeaapprirgRLVTINVLFITGGQFVAYVINGAFSYLPG------GWRWMLGLAAVPAVLQFI 170
                       170
                ....*....|.
gi 6650603  267 YYFFLPESPRW 277
Cdd:cd17360 171 GLLFLPESPRW 181
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
142-244 4.17e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.93  E-value: 4.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  142 TSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILrFFTGLAFPALFQIPFIICMEFMGNSG 221
Cdd:cd17478 237 SLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLPGNV 315
                        90       100
                ....*....|....*....|....*.
gi 6650603  222 RIFSGLMTSLFFGAA---MALLGVVA 244
Cdd:cd17478 316 GLASGLMMGLSFGLGgigAPVLGALA 341
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
141-277 7.07e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 42.24  E-value: 7.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  141 TTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIIL-RFFTGLAFPALFQIPFIICMEFmgn 219
Cdd:cd17356  51 VSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVgRIIAGLGVGFASVLVPVYQSEV--- 127
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6650603  220 SGRIFSGLMTSLfFGAAMALLGVVAMFIR----------RWRQLTFFCNAPFAFYIIYYFFLPESPRW 277
Cdd:cd17356 128 APKHIRGTLVSL-YQLAITIGILVAYCINygthkldgsaQWRIPLGLQIVWGLLLLIGMFFLPESPRW 194
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
397-512 9.13e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 41.79  E-value: 9.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  397 GRRWTLAATMIVCGIGCVSAMFMPDgYPWLVAsASFIGKFGVGSGFAVIYIFAGELYPTVVRAIGMGMSSMVAGSGLLLA 476
Cdd:cd17320  62 GRRPVLLAGLLLFILASLLCALASS-IEQLLI-ARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALA 139
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6650603  477 PHIVnlGKIVKILP-----LLIMGLMALSAGILTFFLPETL 512
Cdd:cd17320 140 PLLG--GLLLLFFGwraifVFLALLGLLLLLLVLLFLPETL 178
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
141-275 1.91e-03

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 40.70  E-value: 1.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  141 TTSFYVGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEF---- 216
Cdd:cd17361  57 TSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMapak 136
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6650603  217 ---MGNSGRIFSGLMTslFFGAAMALLGVVAMFIRRWRQLTFFCNAPFAFYIIYYFFLPESP 275
Cdd:cd17361 137 lrgALNIGFQLAITIG--ILIANLINYGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPETP 196
DUF6077 pfam19554
Family of unknown function (DUF6077); This family of proteins is functionally uncharacterized. ...
149-271 2.81e-03

Family of unknown function (DUF6077); This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 347 and 622 amino acids in length.


Pssm-ID: 437386  Cd Length: 354  Bit Score: 40.25  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603    149 FIGNCLFGyvaDKFGRRRSFFVILTVLIVCGTASSFAkdIESFIILRFFTGLAFPALFQIPFIICM------EFMGNSGR 222
Cdd:pfam19554 214 QIGRELFK---KKKKKIPLFLIFLSVLQLFGNYSIYT--AETFLLTRTWQGKAVLANVVLPLLFYLllrlfeDEQEKKDR 288
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6650603    223 ----------IFSGLMTSL---FFGAAMALLGVVAMFI-RRWRQL--TFFCNAPFAFYIIYYFFL 271
Cdd:pfam19554 289 kewillflvnLAACLLSSMgiiLVPILVGAFALLLAVKkRKWRILlkALLCCIPCVIYALLYLLL 353
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
120-262 3.43e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.85  E-value: 3.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  120 LDSLVTEFNLVCDQQAWIeISTTSFYVGSFIgnCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTG 199
Cdd:cd17321  19 LPTIARDLGASPSQLQWV-VNAYLLAFAALL--LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQG 95
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6650603  200 LAFPALFQIPF-IICMEFMGNS-GRIFSGLMTSLFFGAAMALL--GVVAMFIrRWRqLTFFCNAPFA 262
Cdd:cd17321  96 IGAAAIMPASLaLIAATFPGERrGRALGLWGAVVGIGAALGPLlgGLLLELF-GWR-WIFLINVPIG 160
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
136-201 3.60e-03

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 39.92  E-value: 3.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6650603   136 WIEISTTSFYVGSFIGNCLFGYVADKFGRRR------SFFVILTVLIVCgtassfAKDIESFIILRFFTGLA 201
Cdd:PRK15402  49 WVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPvmlagvAFFILTCLAILL------AQSIEQFTLLRFLQGIG 114
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
141-201 4.03e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 39.90  E-value: 4.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6650603   141 TTSFYVGSF-IGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLA 201
Cdd:PRK11102  31 TLSAYILGFaIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
146-202 4.48e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 39.75  E-value: 4.48e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6650603  146 VGSFIGNCLFGYVADKFGRRRSFFVILTVLIVCGTASSFAKDIESFIILRFFTGLAF 202
Cdd:COG2270 285 IVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVM 341
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
146-272 4.93e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 39.46  E-value: 4.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  146 VGSFIGNCLFGYVADKFGRRRSFFVILTVLI--VCGTASSFAKDIESFIILRFFTGLAFPALFQIPFIICMEFMGNSgRI 223
Cdd:cd17352 229 ISDIVGRILLGLLADKPRIGRLYLYIFTLLIlgLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLE-KL 307
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6650603  224 FSGLMTSLFFGAAMALLGV-VAMFIR----RWRQLTFFCNAPFAFYIIYYFFLP 272
Cdd:cd17352 308 SNAYGLVLLFQGLAALVGPpIAGLLRdytgDYDAAFYFCGACLLLSGVLLFLLP 361
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
118-234 7.69e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 7.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6650603  118 TYLDSLVTEFNLVCDQQAWIEISTTSfyVGSFIGNCLFGYVADKFGRRRSFFVILTV----LIVCGTASSFAKDIESFII 193
Cdd:cd17473 218 IQLPFLLQERGGGSAALIGLALAIAS--LAGAIGALLFGRLKRRLGKRRLLAIGFALmalgFLLLALASGLWVVLLGAIL 295
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6650603  194 LRFFTGLAFPALF-----QIPFiicmefmGNSGRIFSGLMTSLFFG 234
Cdd:cd17473 296 AGLGFGLLLPTLNswamsLVPP-------ELRGRAMGIVTSAFFLG 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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