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Conserved domains on  [gi|6841174|gb|AAF28940|]
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HSPC262, partial [Homo sapiens]

Protein Classification

YbhB/YbcL family Raf kinase inhibitor-like protein( domain architecture ID 10096268)

YbhB/YbcL family Raf kinase inhibitor-like protein similar to mammalian phosphatidylethanolamine-binding protein 1/2 and Schizosaccharomyces pombe mitochondrial 54S ribosomal protein L35

CATH:  3.90.280.10
SCOP:  4002457

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 24-115 3.12e-28

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


:

Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 102.45  E-value: 3.12e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6841174   24 AEYLHWLLTNIPGN-----RVAEGQVTCPYLPPFPARGSGIHRLAFLLFKQDQPIDFSEDARPsPCYQLAQRTFRTFDFY 98
Cdd:cd00866  60 REWLHWLVTNIPGSdtttgLVSKGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLP-PTSGLGRRGFDVREFA 138

                        90
                ....*....|....*..
gi 6841174   99 KKHQETMtPAGLSFFQC 115
Cdd:cd00866 139 KKNGLGL-PVAANFFQV 154
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 24-115 3.12e-28

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 102.45  E-value: 3.12e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6841174   24 AEYLHWLLTNIPGN-----RVAEGQVTCPYLPPFPARGSGIHRLAFLLFKQDQPIDFSEDARPsPCYQLAQRTFRTFDFY 98
Cdd:cd00866  60 REWLHWLVTNIPGSdtttgLVSKGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLP-PTSGLGRRGFDVREFA 138

                        90
                ....*....|....*..
gi 6841174   99 KKHQETMtPAGLSFFQC 115
Cdd:cd00866 139 KKNGLGL-PVAANFFQV 154
PBP pfam01161
Phosphatidylethanolamine-binding protein;
22-72 2.77e-08

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 50.03  E-value: 2.77e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6841174     22 PDA------EYLHWLLTNIPGNRV--AEGQV-----------TCPYLPPFPARGSGIHRLAFLLFKQDQP 72
Cdd:pfam01161  36 PDApkvggsGWLHWVVTNIPATVTelPEGAPagavqglndfgGAGYGGPCPPAGDGPHRYVFTLYALDVP 105
PLN00169 PLN00169
CETS family protein; Provisional
 19-69 3.71e-08

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 50.58  E-value: 3.71e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6841174    19 LLEPDA---------EYLHWLLTNIPGNRVAE-GQVTCPYLPPFPArgSGIHRLAFLLFKQ 69
Cdd:PLN00169  69 MVDPDApspsnpnlrEYLHWLVTDIPATTGATfGQEVVCYESPRPT--AGIHRFVFVLFRQ 127
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 22-81 8.60e-03

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 35.13  E-value: 8.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6841174   22 PDA----EYLHWLLTNIPGNR--VAEGQVTCP----------------YLPPFPARGSGIHRLAFLLFKQDQPIDFSEDA 79
Cdd:COG1881  48 PDAptggGFWHWVVYNIPADVteLPEGAGSADlpagavqgrndfgeagYGGPCPPPGDGPHRYVFTVYALDVELDLPPGA 127


                ..
gi 6841174   80 RP 81
Cdd:COG1881 128 TR 129
 
Name Accession Description Interval E-value
PEBP_euk cd00866
PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; ...
 24-115 3.12e-28

PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). The members in this subgroup are present in eukaryotes. Members here include those in plants such as Arabidopsis thaliana FLOWERING LOCUS (FT) and TERMINAL FLOWER1 (FT1) which function as a promoter and a repressor of the floral transitions, respectively as well as the mammalian Raf kinase inhibitory protein (RKIP) which inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFkappaB signaling cascades. Although their overall structures are similar, the members of the PEBP family have very different substrates and oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176644 [Multi-domain]  Cd Length: 154  Bit Score: 102.45  E-value: 3.12e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6841174   24 AEYLHWLLTNIPGN-----RVAEGQVTCPYLPPFPARGSGIHRLAFLLFKQDQPIDFSEDARPsPCYQLAQRTFRTFDFY 98
Cdd:cd00866  60 REWLHWLVTNIPGSdtttgLVSKGEVLVPYLGPGPPKGTGPHRYVFLLFKQPGGLDFPESKLP-PTSGLGRRGFDVREFA 138

                        90
                ....*....|....*..
gi 6841174   99 KKHQETMtPAGLSFFQC 115
Cdd:cd00866 139 KKNGLGL-PVAANFFQV 154
PBP pfam01161
Phosphatidylethanolamine-binding protein;
22-72 2.77e-08

Phosphatidylethanolamine-binding protein;


Pssm-ID: 460090  Cd Length: 136  Bit Score: 50.03  E-value: 2.77e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6841174     22 PDA------EYLHWLLTNIPGNRV--AEGQV-----------TCPYLPPFPARGSGIHRLAFLLFKQDQP 72
Cdd:pfam01161  36 PDApkvggsGWLHWVVTNIPATVTelPEGAPagavqglndfgGAGYGGPCPPAGDGPHRYVFTLYALDVP 105
PLN00169 PLN00169
CETS family protein; Provisional
 19-69 3.71e-08

CETS family protein; Provisional


Pssm-ID: 177765  Cd Length: 175  Bit Score: 50.58  E-value: 3.71e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6841174    19 LLEPDA---------EYLHWLLTNIPGNRVAE-GQVTCPYLPPFPArgSGIHRLAFLLFKQ 69
Cdd:PLN00169  69 MVDPDApspsnpnlrEYLHWLVTDIPATTGATfGQEVVCYESPRPT--AGIHRFVFVLFRQ 127
PEBP cd00457
PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding ...
 22-77 5.65e-07

PhosphatidylEthanolamine-Binding Protein (PEBP) domain; PhosphatidylEthanolamine-Binding Proteins (PEBPs) are represented in all three major phylogenetic divisions (eukaryotes, bacteria, archaea). A number of biological roles for members of the PEBP family include serine protease inhibition, membrane biogenesis, regulation of flowering plant stem architecture, and Raf-1 kinase inhibition. Although their overall structures are similar, the members of the PEBP family bind very different substrates including phospholipids, opioids, and hydrophobic odorant molecules as well as having different oligomerization states (monomer/dimer/tetramer).


Pssm-ID: 176642  Cd Length: 159  Bit Score: 47.01  E-value: 5.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6841174   22 PDA----EYLHWLLTNIPGNRVAEGQV-----------------------TCPYLPPFPARGSGIHRLAFLLFKQDQPID 74
Cdd:cd00457  48 PDAplgrPIVHGLVYGIPANKTSLSNDdfvvtdngkgglqggfkygknrgGTVYIGPRPPLGHGPHRYFFQVYALDEPLD 127


                ...
gi 6841174   75 FSE 77
Cdd:cd00457 128 RSK 130
PEBP COG1881
Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family ...
 22-81 8.60e-03

Uncharacterized conserved protein, phosphatidylethanolamine-binding protein (PEBP) family [General function prediction only];


Pssm-ID: 441485  Cd Length: 151  Bit Score: 35.13  E-value: 8.60e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6841174   22 PDA----EYLHWLLTNIPGNR--VAEGQVTCP----------------YLPPFPARGSGIHRLAFLLFKQDQPIDFSEDA 79
Cdd:COG1881  48 PDAptggGFWHWVVYNIPADVteLPEGAGSADlpagavqgrndfgeagYGGPCPPPGDGPHRYVFTVYALDVELDLPPGA 127


                ..
gi 6841174   80 RP 81
Cdd:COG1881 128 TR 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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