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Conserved domains on  [gi|7302940|gb|AAF58011|]
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vacuolar H[+] ATPase 44kD subunit, isoform A [Drosophila melanogaster]

Protein Classification

V-type proton ATPase subunit C( domain architecture ID 11141526)

V-type proton ATPase subunit C is a subunit of the peripheral V1 complex of vacuolar ATPase

CATH:  3.30.70.100
Gene Ontology:  GO:0046961|GO:0033180
PubMed:  15473999|20450191
SCOP:  4003895
TCDB:  3.A.2

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
V-ATPase_C pfam03223
V-ATPase subunit C;
5-374 0e+00

V-ATPase subunit C;


:

Pssm-ID: 460851  Cd Length: 367  Bit Score: 611.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940      5 YWIISAPGDKTCQQTYDTMNNLTSKQhnLCNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYVEQITRKVANYLGEVLEDQ 84
Cdd:pfam03223   1 YWLISLPGDKTSDDTWEWLKKALSSG--NSSVSKFNIPDFKVGTLDSLVQLSDELAKLDTQVEGVVKKIADILRDLLEGD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940     85 RDKLHENLMANNTELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLKTKSQAYNNLKGNLQNLEKKKTGSLLT 164
Cdd:pfam03223  79 EDKLAENLLVNGKPVDSYLTSFQWDTAKYPTDKSLKELIDIISKEVTQIDNDLKAKSTAYNNAKSNLQALERKQTGNLSV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    165 RNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYEKITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARE 244
Cdd:pfam03223 159 RSLADIVKPEDFVLDSEYLTTLLVAVPKNLVKDWLKSYETLTDMVVPRSAKKIAEDDEYTLFTVTLFKKVVDEFKHKARE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    245 RKFIVRDFVYNEEELAAGKNEMTKLMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEP 324
Cdd:pfam03223 239 KKFTVRDFKYDEEELEEEKKELDKLAADEKKLWGELLRLLKTNFSEAFIAWIHLKALRVFVESVLRYGLPPNFQAVLIKP 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 7302940    325 NKKSVKRLRDVLNQLYGHLDGASAGGAVSSADNVDiPGLGFGQSEYFPYV 374
Cdd:pfam03223 319 KKKKEKKLKKELNSLFGYLGGNAFSRDKKGKIKKD-EYASLGDQEYYPYV 367
 
Name Accession Description Interval E-value
V-ATPase_C pfam03223
V-ATPase subunit C;
5-374 0e+00

V-ATPase subunit C;


Pssm-ID: 460851  Cd Length: 367  Bit Score: 611.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940      5 YWIISAPGDKTCQQTYDTMNNLTSKQhnLCNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYVEQITRKVANYLGEVLEDQ 84
Cdd:pfam03223   1 YWLISLPGDKTSDDTWEWLKKALSSG--NSSVSKFNIPDFKVGTLDSLVQLSDELAKLDTQVEGVVKKIADILRDLLEGD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940     85 RDKLHENLMANNTELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLKTKSQAYNNLKGNLQNLEKKKTGSLLT 164
Cdd:pfam03223  79 EDKLAENLLVNGKPVDSYLTSFQWDTAKYPTDKSLKELIDIISKEVTQIDNDLKAKSTAYNNAKSNLQALERKQTGNLSV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    165 RNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYEKITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARE 244
Cdd:pfam03223 159 RSLADIVKPEDFVLDSEYLTTLLVAVPKNLVKDWLKSYETLTDMVVPRSAKKIAEDDEYTLFTVTLFKKVVDEFKHKARE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    245 RKFIVRDFVYNEEELAAGKNEMTKLMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEP 324
Cdd:pfam03223 239 KKFTVRDFKYDEEELEEEKKELDKLAADEKKLWGELLRLLKTNFSEAFIAWIHLKALRVFVESVLRYGLPPNFQAVLIKP 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 7302940    325 NKKSVKRLRDVLNQLYGHLDGASAGGAVSSADNVDiPGLGFGQSEYFPYV 374
Cdd:pfam03223 319 KKKKEKKLKKELNSLFGYLGGNAFSRDKKGKIKKD-EYASLGDQEYYPYV 367
V-ATPase_C cd14785
Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H ...
5-378 0e+00

Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H+-ATPase (V-ATPase), a protein that plays a crucial role in the vacuolar system of eukaryotic cells. The main function of V-ATPase is to generate a proton-motive force at the expense of ATP and to cause limited acidification in the internal space (lumen) of several organelles of the vacuolar system. V-ATPases are multi-subunit protein complexes made up of two distinct structures: a peripheral catalytic sector (V1) and a hydrophobic membrane sector (V0) responsible for driving protons; subunit C is one of five polypeptides composing V1. The key function of the C subunit is intimately involved in the reversible dissociation of the V1 and V0 structures. It has also been identified as a mediator of the acidic microenvironment of tumors which it controls by proton extrusion to the extracellular medium. The acidic environment causes tissue damage, activates destructive enzymes in the extracellular matrix, and acquires metastatic cell phenotypes.


Pssm-ID: 270211  Cd Length: 368  Bit Score: 551.84  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    5 YWIISAPGDKTCQQTYDTMNNLTSKQHNlcNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYVEQITRKVANYLGEVLEDQ 84
Cdd:cd14785   1 YWLVSLPLDKTKEQTLEELRQALGKSNL--DVSKFDIPEFKVGTLDSLIALSDDLGKLDAQVESVLRKIARQLRDLLEDD 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940   85 RDKLHENLMANNTELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLKTKSQAYNNLKGNLQNLEKKKTGSLLT 164
Cdd:cd14785  79 SDKLQENLLVNGVSLEEYLTRFQWDEAKYPTKRSLRELVEIISKEVSKIDEDLKTKSAAYNEAKGNLQALERKQTGSLST 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940  165 RNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYEKITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARE 244
Cdd:cd14785 159 RSLADVVKEEDFVLDSEYLTTLLVVVPKNSEKEWLNSYETLTDMVVPRSSKKIAEDEEYALYSVTLFKKVVDEFKNAARE 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940  245 RKFIVRDFVYNEEELAAGKNEMTKLMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEP 324
Cdd:cd14785 239 KKFIVRDFKYDEEAYEEEKEELEKLEAEEKEQETELLRWCRTNFSELFSAWIHLKALRLFVESVLRYGLPPNFQAFLLKP 318
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7302940  325 NKKSVKRLRDVLNQLYGHLDGASaggavSSADNVDIPGL-GFGQSEYFPYVFYKV 378
Cdd:cd14785 319 KKKKEKKLRKILNKLYGHLGSAG-----GNATSEDIPGLlEEGDQEYYPYVSFEI 368
COG5127 COG5127
Vacuolar H+-ATPase V1 sector, subunit C [Energy production and conversion];
3-380 1.45e-77

Vacuolar H+-ATPase V1 sector, subunit C [Energy production and conversion];


Pssm-ID: 227456  Cd Length: 383  Bit Score: 244.46  E-value: 1.45e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    3 SEYWIISAPGDKTCQQTYDTMNNLTSKQHNLCNnyKFHIPDLKVGTLDQLVGLSDDLGKLDTYVEQITRKVANYLGEVLE 82
Cdd:COG5127   4 SDFILVSLPVEEDGSRPDEDQIWDLYGGRSTVS--RFLLPSFKGVSLDGLINQSERLGKLDKQCEGAISKILKIFMGYCR 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940   83 DQRDKLHENLMaNNTELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLKTKSQAYNNLKGNLQNLEKKKTGSL 162
Cdd:COG5127  82 SSNGDRVGKGI-VYGSTPEYGDFFEWDRQSFVTNKSIEKAILLIDGEYRRISKDYREKAEEFDGAKRECEKLQRKTRGSL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940  163 LTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYEKITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHA 242
Cdd:COG5127 161 SDISLGIIVEREDVVEGSEFLTVVYVAVPKALVPEFNRSYETLSPHVSPDSAEKVNSDEEYVLFKVYVFKKGEEDFRTMA 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940  243 RERKFIVRDFVYNEEELAAGKNEMTKLMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILI 322
Cdd:COG5127 241 REEKFMVREFDKNMVLSEEMIAERDRAAEKESAMEKILMRFAHVALTEVFRIWIHIKLLRVYVESVLRYGLPPEFMFFIT 320
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7302940  323 EPNKKSVKRLRDVLNQLYGHLDGASAGGavSSADNVDIPGLGFGQ-------SEYFPYVFYKVNI 380
Cdd:COG5127 321 RGEKKSESKVKAQLIAIAKNLPSNRIVY--EKEGDNNDEGEILFAfaelstdGEYEPFVLFVFNY 383
 
Name Accession Description Interval E-value
V-ATPase_C pfam03223
V-ATPase subunit C;
5-374 0e+00

V-ATPase subunit C;


Pssm-ID: 460851  Cd Length: 367  Bit Score: 611.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940      5 YWIISAPGDKTCQQTYDTMNNLTSKQhnLCNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYVEQITRKVANYLGEVLEDQ 84
Cdd:pfam03223   1 YWLISLPGDKTSDDTWEWLKKALSSG--NSSVSKFNIPDFKVGTLDSLVQLSDELAKLDTQVEGVVKKIADILRDLLEGD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940     85 RDKLHENLMANNTELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLKTKSQAYNNLKGNLQNLEKKKTGSLLT 164
Cdd:pfam03223  79 EDKLAENLLVNGKPVDSYLTSFQWDTAKYPTDKSLKELIDIISKEVTQIDNDLKAKSTAYNNAKSNLQALERKQTGNLSV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    165 RNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYEKITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARE 244
Cdd:pfam03223 159 RSLADIVKPEDFVLDSEYLTTLLVAVPKNLVKDWLKSYETLTDMVVPRSAKKIAEDDEYTLFTVTLFKKVVDEFKHKARE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    245 RKFIVRDFVYNEEELAAGKNEMTKLMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEP 324
Cdd:pfam03223 239 KKFTVRDFKYDEEELEEEKKELDKLAADEKKLWGELLRLLKTNFSEAFIAWIHLKALRVFVESVLRYGLPPNFQAVLIKP 318
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 7302940    325 NKKSVKRLRDVLNQLYGHLDGASAGGAVSSADNVDiPGLGFGQSEYFPYV 374
Cdd:pfam03223 319 KKKKEKKLKKELNSLFGYLGGNAFSRDKKGKIKKD-EYASLGDQEYYPYV 367
V-ATPase_C cd14785
Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H ...
5-378 0e+00

Subunit C of vacuolar H+-ATPase (V-ATPase); This family contains subunit C of vacuolar H+-ATPase (V-ATPase), a protein that plays a crucial role in the vacuolar system of eukaryotic cells. The main function of V-ATPase is to generate a proton-motive force at the expense of ATP and to cause limited acidification in the internal space (lumen) of several organelles of the vacuolar system. V-ATPases are multi-subunit protein complexes made up of two distinct structures: a peripheral catalytic sector (V1) and a hydrophobic membrane sector (V0) responsible for driving protons; subunit C is one of five polypeptides composing V1. The key function of the C subunit is intimately involved in the reversible dissociation of the V1 and V0 structures. It has also been identified as a mediator of the acidic microenvironment of tumors which it controls by proton extrusion to the extracellular medium. The acidic environment causes tissue damage, activates destructive enzymes in the extracellular matrix, and acquires metastatic cell phenotypes.


Pssm-ID: 270211  Cd Length: 368  Bit Score: 551.84  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    5 YWIISAPGDKTCQQTYDTMNNLTSKQHNlcNNYKFHIPDLKVGTLDQLVGLSDDLGKLDTYVEQITRKVANYLGEVLEDQ 84
Cdd:cd14785   1 YWLVSLPLDKTKEQTLEELRQALGKSNL--DVSKFDIPEFKVGTLDSLIALSDDLGKLDAQVESVLRKIARQLRDLLEDD 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940   85 RDKLHENLMANNTELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLKTKSQAYNNLKGNLQNLEKKKTGSLLT 164
Cdd:cd14785  79 SDKLQENLLVNGVSLEEYLTRFQWDEAKYPTKRSLRELVEIISKEVSKIDEDLKTKSAAYNEAKGNLQALERKQTGSLST 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940  165 RNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYEKITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHARE 244
Cdd:cd14785 159 RSLADVVKEEDFVLDSEYLTTLLVVVPKNSEKEWLNSYETLTDMVVPRSSKKIAEDEEYALYSVTLFKKVVDEFKNAARE 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940  245 RKFIVRDFVYNEEELAAGKNEMTKLMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILIEP 324
Cdd:cd14785 239 KKFIVRDFKYDEEAYEEEKEELEKLEAEEKEQETELLRWCRTNFSELFSAWIHLKALRLFVESVLRYGLPPNFQAFLLKP 318
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7302940  325 NKKSVKRLRDVLNQLYGHLDGASaggavSSADNVDIPGL-GFGQSEYFPYVFYKV 378
Cdd:cd14785 319 KKKKEKKLRKILNKLYGHLGSAG-----GNATSEDIPGLlEEGDQEYYPYVSFEI 368
COG5127 COG5127
Vacuolar H+-ATPase V1 sector, subunit C [Energy production and conversion];
3-380 1.45e-77

Vacuolar H+-ATPase V1 sector, subunit C [Energy production and conversion];


Pssm-ID: 227456  Cd Length: 383  Bit Score: 244.46  E-value: 1.45e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940    3 SEYWIISAPGDKTCQQTYDTMNNLTSKQHNLCNnyKFHIPDLKVGTLDQLVGLSDDLGKLDTYVEQITRKVANYLGEVLE 82
Cdd:COG5127   4 SDFILVSLPVEEDGSRPDEDQIWDLYGGRSTVS--RFLLPSFKGVSLDGLINQSERLGKLDKQCEGAISKILKIFMGYCR 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940   83 DQRDKLHENLMaNNTELPQYLTRFQWDMAKYPIKQSLRNIADIISKQIGQIDGDLKTKSQAYNNLKGNLQNLEKKKTGSL 162
Cdd:COG5127  82 SSNGDRVGKGI-VYGSTPEYGDFFEWDRQSFVTNKSIEKAILLIDGEYRRISKDYREKAEEFDGAKRECEKLQRKTRGSL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940  163 LTRNLADLVKKEHFILDSEYLTTLLVIVPKVMANDWLTNYEKITDMIVPRSSQLIQEDADYCLFNVTLFKKVAEEFKLHA 242
Cdd:COG5127 161 SDISLGIIVEREDVVEGSEFLTVVYVAVPKALVPEFNRSYETLSPHVSPDSAEKVNSDEEYVLFKVYVFKKGEEDFRTMA 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7302940  243 RERKFIVRDFVYNEEELAAGKNEMTKLMTDKKKQFGPLVRWLKVNFSEAFCALIHVKALRVFVESVLRYGLPVNFQAILI 322
Cdd:COG5127 241 REEKFMVREFDKNMVLSEEMIAERDRAAEKESAMEKILMRFAHVALTEVFRIWIHIKLLRVYVESVLRYGLPPEFMFFIT 320
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7302940  323 EPNKKSVKRLRDVLNQLYGHLDGASAGGavSSADNVDIPGLGFGQ-------SEYFPYVFYKVNI 380
Cdd:COG5127 321 RGEKKSESKVKAQLIAIAKNLPSNRIVY--EKEGDNNDEGEILFAfaelstdGEYEPFVLFVFNY 383
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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