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Conserved domains on  [gi|7767429|gb|AAF69126|]
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keratocan [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000960)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
48-311 3.15e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 85.90  E-value: 3.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429    48 CPPSFPTALYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEkpfenatqlrwiNLNKNKITNYgiekgalsqlkkllfl 126
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPE------------NLQGNIKTLY---------------- 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   127 fLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENltlLDLQNNKLvdNAFQRDTFKGLKNlmqLNMAKNALRN 206
Cdd:PRK15370 227 -ANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKI--SCLPENLPEELRY---LSVYDNSIRT 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   207 MPPRLPANTMQLFLDNNSIEGIPEnyfNVIPKVAFLRLNHNKLSD--EGLPsrgfdvSSILDLQLSHNQLTKVPR-ISAH 283
Cdd:PRK15370 298 LPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSlpASLP------PELQVLDVSKNQITVLPEtLPPT 368

                        250       260
                 ....*....|....*....|....*...
gi 7767429   284 LQHLHLDHNKIKSVnvsvicpsPSMLPA 311
Cdd:PRK15370 369 ITTLDVSRNALTNL--------PENLPA 388
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
48-311 3.15e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 85.90  E-value: 3.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429    48 CPPSFPTALYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEkpfenatqlrwiNLNKNKITNYgiekgalsqlkkllfl 126
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPE------------NLQGNIKTLY---------------- 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   127 fLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENltlLDLQNNKLvdNAFQRDTFKGLKNlmqLNMAKNALRN 206
Cdd:PRK15370 227 -ANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKI--SCLPENLPEELRY---LSVYDNSIRT 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   207 MPPRLPANTMQLFLDNNSIEGIPEnyfNVIPKVAFLRLNHNKLSD--EGLPsrgfdvSSILDLQLSHNQLTKVPR-ISAH 283
Cdd:PRK15370 298 LPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSlpASLP------PELQVLDVSKNQITVLPEtLPPT 368

                        250       260
                 ....*....|....*....|....*...
gi 7767429   284 LQHLHLDHNKIKSVnvsvicpsPSMLPA 311
Cdd:PRK15370 369 ITTLDVSRNALTNL--------PENLPA 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-302 2.79e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.79e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   89 KPFENATQLRWINLNKNKITNYGIEKGALSQlkkllflfledneleevpsplprsLEQLQLARNKVSRIPQgTFSNLENL 168
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPEELANLTN------------------------LKELDLSNNQLTDLPE-PLGNLTNL 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  169 TLLDLQNNKLVDnafQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTM--QLFLDNNSIEGIPENYFNvIPKVAFLRLNH 246
Cdd:COG4886 162 KSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQITDLPEPLGNLTNleELDLSGNQLTDLPEPLAN-LTNLETLDLSN 237

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 7767429  247 NKLSDegLPSRGfDVSSILDLQLSHNQLTKVPRIS--AHLQHLHLDHNKIKSVNVSVI 302
Cdd:COG4886 238 NQLTD--LPELG-NLTNLEELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKEL 292
LRR_8 pfam13855
Leucine rich repeat;
142-204 3.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.25e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7767429    142 RSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKLvdNAFQRDTFKGLKNLMQLNMAKNAL 204
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 141-333 2.94e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 2.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  141 PRSLEQLQLARNKVSRIPQGT------FSNLENLTLLDLQnnklvDNAFQRDTFKGLKNLMQ------LNMAKNALRNMP 208
Cdd:cd00116  50 QPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLS-----DNALGPDGCGVLESLLRssslqeLKLNNNGLGDRG 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  209 PRLPANTMQ--------LFLDNNSIEGIP----ENYFNVIPKVAFLRLNHNKLSDEGLPS--RGFDVSSILD-LQLSHNQ 273
Cdd:cd00116 125 LRLLAKGLKdlppalekLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEvLDLNNNG 204

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7767429  274 LTK--------VPRISAHLQHLHLDHNKIKSVNVSVICPSpsmLPAERDSfsygphLRYLRLDGNEIK 333
Cdd:cd00116 205 LTDegasalaeTLASLKSLEVLNLGDNNLTDAGAAALASA---LLSPNIS------LLTLSLSCNDIT 263
LRRNT smart00013
Leucine rich repeat N-terminal domain;
42-75 1.07e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 1.07e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 7767429      42 CPMECFCPPsfpTALYCENRGLKEIP-AIPSRIWY 75
Cdd:smart00013   2 CPAPCNCSG---TAVDCSGRGLTEVPlDLPPDTTL 33
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
48-311 3.15e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 85.90  E-value: 3.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429    48 CPPSFPTALYCENRGLKEIPA-IPSRIWYLYLQNNLIETIPEkpfenatqlrwiNLNKNKITNYgiekgalsqlkkllfl 126
Cdd:PRK15370 175 CLKNNKTELRLKILGLTTIPAcIPEQITTLILDNNELKSLPE------------NLQGNIKTLY---------------- 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   127 fLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENltlLDLQNNKLvdNAFQRDTFKGLKNlmqLNMAKNALRN 206
Cdd:PRK15370 227 -ANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKI--SCLPENLPEELRY---LSVYDNSIRT 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   207 MPPRLPANTMQLFLDNNSIEGIPEnyfNVIPKVAFLRLNHNKLSD--EGLPsrgfdvSSILDLQLSHNQLTKVPR-ISAH 283
Cdd:PRK15370 298 LPAHLPSGITHLNVQSNSLTALPE---TLPPGLKTLEAGENALTSlpASLP------PELQVLDVSKNQITVLPEtLPPT 368

                        250       260
                 ....*....|....*....|....*...
gi 7767429   284 LQHLHLDHNKIKSVnvsvicpsPSMLPA 311
Cdd:PRK15370 369 ITTLDVSRNALTNL--------PENLPA 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
89-302 2.79e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.79e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   89 KPFENATQLRWINLNKNKITNYGIEKGALSQlkkllflfledneleevpsplprsLEQLQLARNKVSRIPQgTFSNLENL 168
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDLPEELANLTN------------------------LKELDLSNNQLTDLPE-PLGNLTNL 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  169 TLLDLQNNKLVDnafQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTM--QLFLDNNSIEGIPENYFNvIPKVAFLRLNH 246
Cdd:COG4886 162 KSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQITDLPEPLGNLTNleELDLSGNQLTDLPEPLAN-LTNLETLDLSN 237

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 7767429  247 NKLSDegLPSRGfDVSSILDLQLSHNQLTKVPRIS--AHLQHLHLDHNKIKSVNVSVI 302
Cdd:COG4886 238 NQLTD--LPELG-NLTNLEELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKEL 292
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-290 3.33e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 3.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   54 TALYCENRGLKEIPA-IPS--RIWYLYLQNNLIETIPEkPFENATQLRWINLNKNKITNYGIEkgaLSQLKKLLFLFLED 130
Cdd:COG4886 139 KELDLSNNQLTDLPEpLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEP---LGNLTNLEELDLSG 214

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  131 NELEEVPSPLPR--SLEQLQLARNKVSRIPQgtFSNLENLTLLDLQNNKLVDnafqRDTFKGLKNLMQLNMAKNALRNM- 207
Cdd:COG4886 215 NQLTDLPEPLANltNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD----LPPLANLTNLKTLDLSNNQLTDLk 288

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  208 -----PPRLPANTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEGLPSRGFDVSSILDLQLSHNQLTKVPRISA 282
Cdd:COG4886 289 lkeleLLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368


                ....*...
gi 7767429  283 HLQHLHLD 290
Cdd:COG4886 369 LGLLGLLE 376
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-333 7.54e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 7.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   63 LKEIPAIPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPR 142
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  143 SLEQLQLARNKVSRIPQGT---------FSNLENLTLLDLQNNKLVDNAfqrDTFKGLKNLMQLNMAKNALRNMPPRLPA 213
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTeldlsgneeLSNLTNLESLDLSGNQLTDLP---EELANLTNLKELDLSNNQLTDLPEPLGN 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  214 NTM--QLFLDNNSIEGIPENYFNvIPKVAFLRLNHNKLSDegLPSRGFDVSSILDLQLSHNQLTKVPR-ISA--HLQHLH 288
Cdd:COG4886 158 LTNlkSLDLSNNQLTDLPEELGN-LTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQLTDLPEpLANltNLETLD 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 7767429  289 LDHNKIKSvnvsvicpspsmLPaerdSFSYGPHLRYLRLDGNEIK 333
Cdd:COG4886 235 LSNNQLTD------------LP----ELGNLTNLEELDLSNNQLT 263
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 138-347 1.56e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 1.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   138 SPLPRsLEQLQLARNKVS-RIPQgTFSNLENLTLLDLQNNKLVDNAfqRDTFKGLKNLMQLNMAKNALRN-MPPRLPA-- 213
Cdd:PLN00113 329 TSLPR-LQVLQLWSNKFSgEIPK-NLGKHNNLTVLDLSTNNLTGEI--PEGLCSSGNLFKLILFSNSLEGeIPKSLGAcr 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   214 NTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEgLPSRGFDVSSILDLQLSHNQLT-KVPRI--SAHLQHLHLD 290
Cdd:PLN00113 405 SLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGR-INSRKWDMPSLQMLSLARNKFFgGLPDSfgSKRLENLDLS 483

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 7767429   291 HNKIKSvnvsvicpspsMLPAERDSFsygPHLRYLRLDGNEIKPPIPMALMTCFRLL 347
Cdd:PLN00113 484 RNQFSG-----------AVPRKLGSL---SELMQLKLSENKLSGEIPDELSSCKKLV 526
LRR_8 pfam13855
Leucine rich repeat;
142-204 3.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 3.25e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7767429    142 RSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKLvdNAFQRDTFKGLKNLMQLNMAKNAL 204
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL--TTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 131-294 1.96e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.93  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   131 NELE-EVPSPLP--RSLEQLQLARNKVS-RIPQGtFSNLENLTLLDLQNNKLVDNAFQRDTfkGLKNLMQLNMAKNA-LR 205
Cdd:PLN00113 390 NSLEgEIPKSLGacRSLRRVRLQDNSFSgELPSE-FTKLPLVYFLDISNNNLQGRINSRKW--DMPSLQMLSLARNKfFG 466

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   206 NMPPRLPANTMQ-LFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEgLPSRGFDVSSILDLQLSHNQLT-KVPRISAH 283
Cdd:PLN00113 467 GLPDSFGSKRLEnLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGE-IPDELSSCKKLVSLDLSHNQLSgQIPASFSE 545

                        170
                 ....*....|....
gi 7767429   284 ---LQHLHLDHNKI 294
Cdd:PLN00113 546 mpvLSQLDLSQNQL 559
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 141-333 2.94e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 2.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  141 PRSLEQLQLARNKVSRIPQGT------FSNLENLTLLDLQnnklvDNAFQRDTFKGLKNLMQ------LNMAKNALRNMP 208
Cdd:cd00116  50 QPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLS-----DNALGPDGCGVLESLLRssslqeLKLNNNGLGDRG 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  209 PRLPANTMQ--------LFLDNNSIEGIP----ENYFNVIPKVAFLRLNHNKLSDEGLPS--RGFDVSSILD-LQLSHNQ 273
Cdd:cd00116 125 LRLLAKGLKdlppalekLVLGRNRLEGAScealAKALRANRDLKELNLANNGIGDAGIRAlaEGLKANCNLEvLDLNNNG 204

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7767429  274 LTK--------VPRISAHLQHLHLDHNKIKSVNVSVICPSpsmLPAERDSfsygphLRYLRLDGNEIK 333
Cdd:cd00116 205 LTDegasalaeTLASLKSLEVLNLGDNNLTDAGAAALASA---LLSPNIS------LLTLSLSCNDIT 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-207 6.03e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 6.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   54 TALYCENRGLKEIPAIPS--RIWYLYLQNNLIETIPekPFENATQLRWINLNKNKITnygiekgalsqlkkllflfledn 131
Cdd:cd21340   5 THLYLNDKNITKIDNLSLckNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIE----------------------- 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  132 ELEEVpSPLPRsLEQLQLARNKVSRIpqgtfSNLEN---------------------------------LTLLDLQNNKL 178
Cdd:cd21340  60 KIENL-ENLVN-LKKLYLGGNRISVV-----EGLENltnleelhienqrlppgekltfdprslaalsnsLRVLNISGNNI 132

                       170       180
                ....*....|....*....|....*....
gi 7767429  179 VDNAFqrdtFKGLKNLMQLNMAKNALRNM 207
Cdd:cd21340 133 DSLEP----LAPLRNLEQLDASNNQISDL 157
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 80-291 3.69e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 3.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429    80 NNLIETIPEKPFENATQLRWINLNKNKITNyGIEKGALSqlkKLLFLFLEDNELE-EVPSPLP--RSLEQLQLARNK-VS 155
Cdd:PLN00113 103 NQLSGPIPDDIFTTSSSLRYLNLSNNNFTG-SIPRGSIP---NLETLDLSNNMLSgEIPNDIGsfSSLKVLDLGGNVlVG 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   156 RIPqGTFSNLENLTLLDLQNNKLVdNAFQRDTFKgLKNLMQLNMAKNalrNMPPRLPANTMQL----FLD---NNSIEGI 228
Cdd:PLN00113 179 KIP-NSLTNLTSLEFLTLASNQLV-GQIPRELGQ-MKSLKWIYLGYN---NLSGEIPYEIGGLtslnHLDlvyNNLTGPI 252

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7767429   229 PENYFNvIPKVAFLRLNHNKLSDEgLPSRGFDVSSILDLQLSHNQLT-KVPRISAHLQHLHLDH 291
Cdd:PLN00113 253 PSSLGN-LKNLQYLFLYQNKLSGP-IPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILH 314
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
50-184 6.68e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.85  E-value: 6.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429    50 PSFPTALY---CENRGLKEIPAIPSRIWYLYLQNNLIETIPEKPfenaTQLRWINLNKNKITNYGIEKGALSQlkkllfL 126
Cdd:PRK15387 338 PTLPSGLQelsVSDNQLASLPTLPSELYKLWAYNNRLTSLPALP----SGLKELIVSGNRLTSLPVLPSELKE------L 407

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 7767429   127 FLEDNELEEVPSpLPRSLEQLQLARNKVSRIPQgTFSNLENLTLLDLQNNKLVDNAFQ 184
Cdd:PRK15387 408 MVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPE-SLIHLSSETTVNLEGNPLSERTLQ 463
LRRNT smart00013
Leucine rich repeat N-terminal domain;
42-75 1.07e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 1.07e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 7767429      42 CPMECFCPPsfpTALYCENRGLKEIP-AIPSRIWY 75
Cdd:smart00013   2 CPAPCNCSG---TAVDCSGRGLTEVPlDLPPDTTL 33
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
48-284 3.50e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.54  E-value: 3.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429    48 CPPSFPTALYCENRGLKEIPAIPSRIWYLYLQNNLIETIPEKPfenaTQLRWINLNKNKITNYGIEKGALSQLKKLlflf 127
Cdd:PRK15387 219 CLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPALPSGLCKLWIF---- 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   128 leDNELEEVPSpLPRSLEQLQLARNKVSRIPqgtfSNLENLTLLDLQNNKLVdnafqrdTFKGLKN-LMQLNMAKNALRN 206
Cdd:PRK15387 291 --GNQLTSLPV-LPPGLQELSVSDNQLASLP----ALPSELCKLWAYNNQLT-------SLPTLPSgLQELSVSDNQLAS 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   207 MPPrLPANTMQLFLDNNSIEGIPE------------NYFNVIPkVAFLRLNHNKLSDEGLPSRGFDVSSILDLQLSHNQL 274
Cdd:PRK15387 357 LPT-LPSELYKLWAYNNRLTSLPAlpsglkelivsgNRLTSLP-VLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQL 434

                        250
                 ....*....|
gi 7767429   275 TKVPRISAHL 284
Cdd:PRK15387 435 TRLPESLIHL 444
LRR_8 pfam13855
Leucine rich repeat;
167-225 3.62e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 3.62e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7767429    167 NLTLLDLQNNKLVDnaFQRDTFKGLKNLMQLNMAKNALRNMPPR----LPANTMqLFLDNNSI 225
Cdd:pfam13855   2 NLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLPSLRY-LDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
267-332 2.23e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.23e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429    267 LQLSHNQLTKVPRIS----AHLQHLHLDHNKIKSVNvsvicpspsmlpaeRDSFSYGPHLRYLRLDGNEI 332
Cdd:pfam13855   6 LDLSNNRLTSLDDGAfkglSNLKVLDLSNNLLTTLS--------------PGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-332 4.40e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 4.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  142 RSLEQLQLARNKVSRIPQgtFSNLENLTLLDLQNNKLvdnafqrDTFKGLKNLMQLNmaknalrnmpprlpantmQLFLD 221
Cdd:cd21340  24 KNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQI-------EKIENLENLVNLK------------------KLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429  222 NNSI---EGIpENyfnvIPKVAFLRLNHNKL-SDEGLPsrgFDVSSILDLQ-------LSHNQLTKVPRISA--HLQHLH 288
Cdd:cd21340  77 GNRIsvvEGL-EN----LTNLEELHIENQRLpPGEKLT---FDPRSLAALSnslrvlnISGNNIDSLEPLAPlrNLEQLD 148

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 7767429  289 LDHNKIKsvNVSVICpspsmlpaerDSFSYGPHLRYLRLDGNEI 332
Cdd:cd21340 149 ASNNQIS--DLEELL----------DLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 144-274 4.71e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 4.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429   144 LEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKLVDNAfqRDTFKGLKNLMQLNMAKNalrNMPPRLPANtmqlfldnn 223
Cdd:PLN00113 477 LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEI--PDELSSCKKLVSLDLSHN---QLSGQIPAS--------- 542

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 7767429   224 siegipenyFNVIPKVAFLRLNHNKLSDEgLPSRGFDVSSILDLQLSHNQL 274
Cdd:PLN00113 543 ---------FSEMPVLSQLDLSQNQLSGE-IPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
75-178 2.54e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7767429     75 YLYLQNNLIETIPEKPFENATQLRWINLNKNKITnygiekgalsqlkkllflfledneleevpsplprsleqlqlarnkv 154
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT---------------------------------------------- 38

                          90       100
                  ....*....|....*....|....
gi 7767429    155 sRIPQGTFSNLENLTLLDLQNNKL 178
Cdd:pfam13855  39 -TLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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