NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|9949214|gb|AAG06492|]
View 

secretion protein XcpP [Pseudomonas aeruginosa PAO1]

Protein Classification

type II secretion system protein C( domain architecture ID 10568360)

type II secretion system protein C is involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of folded proteins across the outer membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
T2SSC pfam11356
Type II secretion system protein C; This is the greater N-terminal region of GspC-type ...
 44-165 5.87e-23

Type II secretion system protein C; This is the greater N-terminal region of GspC-type proteins. GspC proteins form part of the sophisticated transport mechanism of Gram-negative pathogens for injecting divers proteins into their hosts, a type-II secretion system - T2SS. The region is made up of a short N-terminal cytoplasmic domain that is followed by the single transmembrane helix, a Pro-rich linker, and the so-called homology region domain in the periplasm. This inner membrane GspC interacts with the outer membrane secretin GspD via periplasmic domains, an interaction which is critical for the effectiveness of type II secretion.


:

Pssm-ID: 431837  Cd Length: 142  Bit Score: 90.52  E-value: 5.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214     44 MSISLAWQAAG--WLRLQRSP------VAVAASPVSHESIRSDPTRLAR--LFGTSAQDPNAP--------PPATNLDLV 105
Cdd:pfam11356   3 LLALLAWLAARltWRLLAPAPpataaaASWAPSPASSSADRLDVAGIASlnLFGKAAPQALAPktapvvvdAPATRLNLT 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214    106 LKGSFVQSDPKLSSAIIQRQGDKPHRYAVGGEISDGVKLHAVYRDRVELQRGGRLESLPF 165
Cdd:pfam11356  83 LLGVVASSDPERGLAIIAERGKQEQTYRIGDEIPGGATLVAVYADRVIIRRNGRLETLML 142
 
Name Accession Description Interval E-value
T2SSC pfam11356
Type II secretion system protein C; This is the greater N-terminal region of GspC-type ...
 44-165 5.87e-23

Type II secretion system protein C; This is the greater N-terminal region of GspC-type proteins. GspC proteins form part of the sophisticated transport mechanism of Gram-negative pathogens for injecting divers proteins into their hosts, a type-II secretion system - T2SS. The region is made up of a short N-terminal cytoplasmic domain that is followed by the single transmembrane helix, a Pro-rich linker, and the so-called homology region domain in the periplasm. This inner membrane GspC interacts with the outer membrane secretin GspD via periplasmic domains, an interaction which is critical for the effectiveness of type II secretion.


Pssm-ID: 431837  Cd Length: 142  Bit Score: 90.52  E-value: 5.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214     44 MSISLAWQAAG--WLRLQRSP------VAVAASPVSHESIRSDPTRLAR--LFGTSAQDPNAP--------PPATNLDLV 105
Cdd:pfam11356   3 LLALLAWLAARltWRLLAPAPpataaaASWAPSPASSSADRLDVAGIASlnLFGKAAPQALAPktapvvvdAPATRLNLT 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214    106 LKGSFVQSDPKLSSAIIQRQGDKPHRYAVGGEISDGVKLHAVYRDRVELQRGGRLESLPF 165
Cdd:pfam11356  83 LLGVVASSDPERGLAIIAERGKQEQTYRIGDEIPGGATLVAVYADRVIIRRNGRLETLML 142
PulC COG3031
Type II secretory pathway, component PulC [Intracellular trafficking, secretion, and vesicular ...
 95-215 7.01e-21

Type II secretory pathway, component PulC [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442267 [Multi-domain]  Cd Length: 220  Bit Score: 86.96  E-value: 7.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214   95 APPPATNLDLVLKGSFVQSDPKLSSAIIQRQGDKPHRYAVGGEISDGVKLHAVYRDRVELQRGGRLESLPFPHRSGGLLA 174
Cdd:COG3031  17 TDAPETRLNLTLLGVVASSDPERSFAIIAEGGGKQKSYRVGDEIPGGATLVAVYRDRVILSNNGRLETLMLDGEDYAAPA 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 9949214  175 SADDITSENDSIEqlqslQDENAAALRERLDALRQQMEATP 215
Cdd:COG3031  97 AAAAAPASSPAAS-----SAAASAGGQEELEVSRDELLANP 132
typeII_sec_gspC TIGR01713
type II secretion system protein C; This model represents GspC, protein C of the main terminal ...
 39-191 1.27e-07

type II secretion system protein C; This model represents GspC, protein C of the main terminal branch of the general secretion pathway, also called type II secretion. This system transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273770 [Multi-domain]  Cd Length: 259  Bit Score: 50.98  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214     39 ALIIAMSISLAWQAAGWLRLQRSPVAVAASPVSHESIRSDPTR-------LARLFG-----------TSAQDPNAPPPAt 100
Cdd:TIGR01713   2 ILTFILLVFISQQLGYILWNVSLPINFVPTIVVSKQISVNLANlqpsdlkLFELFGvfneksvsevkTSPVSVNAPVSP- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214    101 nLDLVLKGSFVQSDPKLSSAIIQrQGDKPHRYAVGGEISDG-VKLHAVYRDRVELQRGGRLESLPFPHRSGGLLASADDI 179
Cdd:TIGR01713  81 -LSLKLTGIVASSDRIRSIAIIE-EGSEQVSLGINESFEGYkAKIAKIEPDRVIFEYNGRYEPLELKNTKGEKSNNSSEI 158

                         170
                  ....*....|..
gi 9949214    180 TSENDSIEQLQS 191
Cdd:TIGR01713 159 VVSRRIIEELTK 170
 
Name Accession Description Interval E-value
T2SSC pfam11356
Type II secretion system protein C; This is the greater N-terminal region of GspC-type ...
 44-165 5.87e-23

Type II secretion system protein C; This is the greater N-terminal region of GspC-type proteins. GspC proteins form part of the sophisticated transport mechanism of Gram-negative pathogens for injecting divers proteins into their hosts, a type-II secretion system - T2SS. The region is made up of a short N-terminal cytoplasmic domain that is followed by the single transmembrane helix, a Pro-rich linker, and the so-called homology region domain in the periplasm. This inner membrane GspC interacts with the outer membrane secretin GspD via periplasmic domains, an interaction which is critical for the effectiveness of type II secretion.


Pssm-ID: 431837  Cd Length: 142  Bit Score: 90.52  E-value: 5.87e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214     44 MSISLAWQAAG--WLRLQRSP------VAVAASPVSHESIRSDPTRLAR--LFGTSAQDPNAP--------PPATNLDLV 105
Cdd:pfam11356   3 LLALLAWLAARltWRLLAPAPpataaaASWAPSPASSSADRLDVAGIASlnLFGKAAPQALAPktapvvvdAPATRLNLT 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214    106 LKGSFVQSDPKLSSAIIQRQGDKPHRYAVGGEISDGVKLHAVYRDRVELQRGGRLESLPF 165
Cdd:pfam11356  83 LLGVVASSDPERGLAIIAERGKQEQTYRIGDEIPGGATLVAVYADRVIIRRNGRLETLML 142
PulC COG3031
Type II secretory pathway, component PulC [Intracellular trafficking, secretion, and vesicular ...
 95-215 7.01e-21

Type II secretory pathway, component PulC [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442267 [Multi-domain]  Cd Length: 220  Bit Score: 86.96  E-value: 7.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214   95 APPPATNLDLVLKGSFVQSDPKLSSAIIQRQGDKPHRYAVGGEISDGVKLHAVYRDRVELQRGGRLESLPFPHRSGGLLA 174
Cdd:COG3031  17 TDAPETRLNLTLLGVVASSDPERSFAIIAEGGGKQKSYRVGDEIPGGATLVAVYRDRVILSNNGRLETLMLDGEDYAAPA 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 9949214  175 SADDITSENDSIEqlqslQDENAAALRERLDALRQQMEATP 215
Cdd:COG3031  97 AAAAAPASSPAAS-----SAAASAGGQEELEVSRDELLANP 132
typeII_sec_gspC TIGR01713
type II secretion system protein C; This model represents GspC, protein C of the main terminal ...
 39-191 1.27e-07

type II secretion system protein C; This model represents GspC, protein C of the main terminal branch of the general secretion pathway, also called type II secretion. This system transports folded proteins across the bacterial outer membrane and is widely distributed in Gram-negative pathogens. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273770 [Multi-domain]  Cd Length: 259  Bit Score: 50.98  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214     39 ALIIAMSISLAWQAAGWLRLQRSPVAVAASPVSHESIRSDPTR-------LARLFG-----------TSAQDPNAPPPAt 100
Cdd:TIGR01713   2 ILTFILLVFISQQLGYILWNVSLPINFVPTIVVSKQISVNLANlqpsdlkLFELFGvfneksvsevkTSPVSVNAPVSP- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9949214    101 nLDLVLKGSFVQSDPKLSSAIIQrQGDKPHRYAVGGEISDG-VKLHAVYRDRVELQRGGRLESLPFPHRSGGLLASADDI 179
Cdd:TIGR01713  81 -LSLKLTGIVASSDRIRSIAIIE-EGSEQVSLGINESFEGYkAKIAKIEPDRVIFEYNGRYEPLELKNTKGEKSNNSSEI 158

                         170
                  ....*....|..
gi 9949214    180 TSENDSIEQLQS 191
Cdd:TIGR01713 159 VVSRRIIEELTK 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH