|
Name |
Accession |
Description |
Interval |
E-value |
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-948 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1711.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 1 MDKTYQPHAIETSWYETWESNDYFAPS--GEGQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTD 78
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADpdSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 79 HAGIATQMVVERQLGAQGVSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLH 158
Cdd:COG0525 83 HAGIATQAVVERQLAEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 159 EDGLIYRGKRLVNWDTKLHTAISDLEVENHDEKGHLWHLRYPLVNGAktseglDYLVVATTRPETLLGDAAVAVHPEDER 238
Cdd:COG0525 163 EKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADGS------GYIVVATTRPETMLGDTAVAVHPEDER 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 239 YAKLIGQFAELPIVGRHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKnaavlaqaqvfhlDGSVN 318
Cdd:COG0525 237 YKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDE-------------DGTIN 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 319 PNldpslPQSYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLTDQWYVSTKPLAEDAIAAVEDGR 398
Cdd:COG0525 304 EN-----AGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 399 IQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRDEVEVRTKHKLGNeaeLRQDEDVLDTWFSSGL 478
Cdd:COG0525 379 IKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPDGEVYVARTEPEACAKAGSVN---LTQDEDVLDTWFSSAL 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 479 WTFSTLGWPQQTEFLKTFHPTDVLVTGFDIIFFWVARMIMLTMHLVKnpdgtpQIPFKTVYVHGLVRDGQGQKMSKSKGN 558
Cdd:COG0525 456 WPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------EVPFKDVYIHGLVRDEQGRKMSKSKGN 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 559 VLDPLDIVDgidldtllqkrtsgmmqpklaekiakqtraefpegiaSYGTDALRFTFCSLASTGRDIKFDMGRVEGFRNF 638
Cdd:COG0525 530 VIDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIKFDEERVEGYRNF 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 639 CNKIWNAANFVIENTDGQDTGVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLELVK 718
Cdd:COG0525 573 ANKLWNASRFVLMNLEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELAK 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 719 PVLWDENApiERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRIKGqaGKEGPTLMLQPWPVADEGRIDAAAEGDIEW 798
Cdd:COG0525 653 PRLYGGDE--AAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPP--RKEGESIMLAPWPEADEELIDEEAEAEFEW 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 799 VKALMLGVRQIRGEMNISMAKRIDIILKNASPSDHRRLADNEPLLMKLAKLESIRVLeAGEEAPMSATALVGDMEVLVPM 878
Cdd:COG0525 729 LKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITIL-VDEKPEGAASAVVGGAEVFLPL 807
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 879 AGLIDKSAELGRLDKEIQRLEGEVKRVGGKLSNEGFVAKAPADVIEKERAKLAEAEQALAKLAEQRQKIA 948
Cdd:COG0525 808 EGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARLK 877
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-949 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1659.85 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 1 MDKTYQPHAIETSWYETWESNDYFAPSG-EGQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDH 79
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPDDnSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTDH 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 80 AGIATQMVVERQLGAQGVSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHE 159
Cdd:PRK05729 85 AGIATQMVVERQLAAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 160 DGLIYRGKRLVNWDTKLHTAISDLEVENHDEKGHLWHLRYPLVNGAktseglDYLVVATTRPETLLGDAAVAVHPEDERY 239
Cdd:PRK05729 165 KGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADGS------DYLVVATTRPETMLGDTAVAVNPEDERY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 240 AKLIGQFAELPIVGRHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKnaavlaqaqvfhlDGSVNP 319
Cdd:PRK05729 239 KHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDE-------------DGTINE 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 320 NldpslPQSYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLTDQWYVSTKPLAEDAIAAVEDGRI 399
Cdd:PRK05729 306 N-----PGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGEI 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 400 QFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRDEVEVRTKhklgneAELRQDEDVLDTWFSSGLW 479
Cdd:PRK05729 381 KFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYVGREEPEAREK------ALLTQDEDVLDTWFSSALW 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 480 TFSTLGWPQQTEFLKTFHPTDVLVTGFDIIFFWVARMIMLTMHLVKnpdgtpQIPFKTVYVHGLVRDGQGQKMSKSKGNV 559
Cdd:PRK05729 455 PFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------QVPFKDVYIHGLVRDEQGRKMSKSKGNV 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 560 LDPLDIVDgidldtllqkrtsgmmqpklaekiakqtraefpegiaSYGTDALRFTFCSLASTGRDIKFDMGRVEGFRNFC 639
Cdd:PRK05729 529 IDPLDLID-------------------------------------KYGADALRFTLAALASPGRDIRFDEERVEGYRNFA 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 640 NKIWNAANFVIENTDGQDTGVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLELVKP 719
Cdd:PRK05729 572 NKLWNASRFVLMNLEGADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELAKP 651
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 720 VLWDenapiERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRIKGQAGKEgpTLMLQPWPVADEGRiDAAAEGDIEWV 799
Cdd:PRK05729 652 VLQE-----AAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEE--SIMLAPWPEADEAI-DEAAEAEFEWL 723
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 800 KALMLGVRQIRGEMNISMAKRIDIILKNASPSDHRRLADNEPLLMKLAKLESIRVLEAGEEAP-MSATALVGDMEVLVPM 878
Cdd:PRK05729 724 KELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPeGAASAVVGGAELFLPL 803
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9950009 879 AGLIDKSAELGRLDKEIQRLEGEVKRVGGKLSNEGFVAKAPADVIEKERAKLAEAEQALAKLAEQRQKIAA 949
Cdd:PRK05729 804 EGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLKA 874
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-931 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1260.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 1 MDKTYQPHAIETSWYETWESNDYFAPSGE--GQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTD 78
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNsnKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 79 HAGIATQMVVERQLGAQGVSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLH 158
Cdd:TIGR00422 81 HAGIATQVKVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 159 EDGLIYRGKRLVNWDTKLHTAISDLEVENHDEKGHLWHLRYPLVNGAKtseglDYLVVATTRPETLLGDAAVAVHPEDER 238
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGSK-----DYLVVATTRPETMFGDTAVAVHPEDER 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 239 YAKLIGQFAELPIVGRHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKnaavlaqaqvfhlDGSVN 318
Cdd:TIGR00422 236 YKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDE-------------DGLLN 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 319 PNLdpslpQSYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLTDQWYVSTKPLAEDAIAAVEDGR 398
Cdd:TIGR00422 303 ENA-----GKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGE 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 399 IQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWY-DEAGNVYVGRDEVEVRTKHKLGNEAELRQDEDVLDTWFSSG 477
Cdd:TIGR00422 378 IKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYcKECGEVYVAKEEPLPDDKTNTGPSVELEQDTDVLDTWFSSS 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 478 LWTFSTLGWPQQTEFLKTFHPTDVLVTGFDIIFFWVARMIMLTMHLVKnpdgtpQIPFKTVYVHGLVRDGQGQKMSKSKG 557
Cdd:TIGR00422 458 LWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTG------QVPFKEVYIHGLVRDEQGRKMSKSLG 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 558 NVLDPLDIvdgidldtllqkrtsgmmqpklaekiakqtraefpegIASYGTDALRFTFCSLASTGRDIKFDMGRVEGFRN 637
Cdd:TIGR00422 532 NVIDPLDV-------------------------------------IEKYGADALRFTLASLVTPGDDINFDWKRVESARN 574
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 638 FCNKIWNAANFVIENTDGQDTGVNGEpVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLELV 717
Cdd:TIGR00422 575 FLNKLWNASRFVLMNLSDDLELSGGE-EKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIELV 653
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 718 KPVLWDENApiERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRIKGQAgkegPTLMLQPWPVADEGRIDAAAEGDIE 797
Cdd:TIGR00422 654 KYRLYNGNE--AEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGA----DSIMLQSYPVVDAEFVDEEAEKAFE 727
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 798 WVKALMLGVRQIRGEMNISMAKRIDIILKNASPSDHRRLADNEPLLMKLAKLESIRVLEAGEEAPMSATALVGDMEVLVP 877
Cdd:TIGR00422 728 LLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVVELVPGFEIIIP 807
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....
gi 9950009 878 MAGLIDKSAELGRLDKEIQRLEGEVKRVGGKLSNEGFVAKAPADVIEKERAKLA 931
Cdd:TIGR00422 808 VKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKLE 861
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-944 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1064.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 1 MDKTYQPHAIETSWYETWESNDYFAPS------GEGQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQ 74
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAedakslNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 75 PGTDHAGIATQMVVERQL-GAQGVSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEA 153
Cdd:PTZ00419 104 PGTDHAGIATQVVVEKKLmKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 154 FVRLHEDGLIYRGKRLVNWDTKLHTAISDLEVENHD----------------EKGHLWHLRYPLVNGaktseGLDYLVVA 217
Cdd:PTZ00419 184 FVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEiekptkitipgydkkvEVGVLWHFAYPLEDS-----GQEEIVVA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 218 TTRPETLLGDAAVAVHPEDERYAKLIGQFAELP-IVGRHIPIIADE-YVDREFGTGCVKITPAHDFNDYEVGKRHDLPLI 295
Cdd:PTZ00419 259 TTRIETMLGDVAVAVHPKDERYKKLHGKELIHPfIPDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFI 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 296 NIFDknaavlaqaqvfhLDGSVNPNLDPslpqsYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWL 375
Cdd:PTZ00419 339 NIFT-------------LDGKINENGGE-----FAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPML 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 376 TDQWYVSTKPLAEDAIAAVEDGRIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAW-----------YDEAGNVyV 444
Cdd:PTZ00419 401 IPQWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYrviskgpetdpSDEEPWV-V 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 445 GRDEVEV--RTKHKLGN---EAELRQDEDVLDTWFSSGLWTFSTLGWPQQTEFLKTFHPTDVLVTGFDIIFFWVARMIML 519
Cdd:PTZ00419 480 ARSEEEAleKAKKKFGLseeDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMM 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 520 TMHLVKnpdgtpQIPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDGIDLDTLLQKRTSGMMQPKLAEKIAKQTRAEF 599
Cdd:PTZ00419 560 SLHLTD------KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEF 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 600 PEGIASYGTDALRFTFCSLASTGRDIKFDMGRVEGFRNFCNKIWNAANFVIENTDGQDTGVNGE---PVELSS---VDRW 673
Cdd:PTZ00419 634 PNGIPECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTlfkPNNVESlpwEDKW 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 674 IISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLELVKPVLwDENAPIERQRGTRRTLIRVLETALRLAHPFM 753
Cdd:PTZ00419 714 ILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRL-SKQSDGERKQHAQDVLHTVLDIGLRLLHPMM 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 754 PFITEEIWQRIKGQAGKEgPTLMLQPWPVADEGRIDAAAEGDIEWVKALMLGVRQIRGEMNISMAKRIDIILKNASPSDH 833
Cdd:PTZ00419 793 PFITEELYQRLPNYLRKS-ESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELI 871
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 834 RRLADNEPLLMKLAKLESIRVLEAGEEAPMSATALVGDM-----EVLVPMAGLIDKSAELGRLDKEIQRLEGEVKRVGGK 908
Cdd:PTZ00419 872 ELIESAENLISTLAKIGSVSVIPPIEEEAEVPKGCGFDVvdnkvIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKK 951
|
970 980 990 1000
....*....|....*....|....*....|....*....|...
gi 9950009 909 LSNEGFVAKAPADV-------IEKERAKLAEAEQALAKLAEQR 944
Cdd:PTZ00419 952 ISIPNYEDKVPEDVrklndekIDELNEEIKQLEQAIEELKSLL 994
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
1-948 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 1015.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 1 MDKTYQPHAIETSWYETWESNDYF----APSGEgQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPG 76
Cdd:PRK14900 15 LAKGYEHREVEARWYPFWQERGYFhgdeHDRTR-PPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 77 TDHAGIATQMVVERQL-GAQGVSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFV 155
Cdd:PRK14900 94 TDHAGIATQMIVEKELkKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 156 RLHEDGLIYRGKRLVNWDTKLHTAISDLEVENHDEK-GHLWHLRYPLVNGAKTsegldyLVVATTRPETLLGDAAVAVHP 234
Cdd:PRK14900 174 RLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHqGELWSFAYPLADGSGE------IVVATTRPETMLGDTAVAVHP 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 235 EDERYAKLIGQFAELPIVGRHIPIIAD-EYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKNAAVLAQAQvfhl 313
Cdd:PRK14900 248 LDPRYMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAG---- 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 314 dgsvnpnldpslpqSYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLTDQWYVSTKPLAEDAIAA 393
Cdd:PRK14900 324 --------------PLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEA 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 394 VEDGRIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRDEVEVRTKhklGNEAELRQDEDVLDTW 473
Cdd:PRK14900 390 VEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVARETPEACST---CGKAELRQDEDVLDTW 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 474 FSSGLWTFSTLGWPQQTEFLKTFHPTDVLVTGFDIIFFWVARMIMLTMHLVKnpdgtpQIPFKTVYVHGLVRDGQGQKMS 553
Cdd:PRK14900 467 FSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMG------EVPFRTVYLHPMVRDEKGQKMS 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 554 KSKGNVLDPLDIvdgidldtllqkrtsgmmqpklaekiakqtraefpegIASYGTDALRFTFCSLASTGRDIKFDMGRVE 633
Cdd:PRK14900 541 KTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTAQGRDIKLAKERIE 583
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 634 GFRNFCNKIWNAANFVIENTDG-QDTGVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAW 712
Cdd:PRK14900 584 GYRAFANKLWNASRFALMNLSGyQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDW 663
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 713 YLELVKPVLWDENApiERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRIKGQAGKEGP--TLMLQPWPVADEgrIDA 790
Cdd:PRK14900 664 YIELAKEALASEDP--EARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQVGASAWadSVLAAEYPRKGE--ADE 739
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 791 AAEGDIEWVKALMLGVRQIRGEMNISMAKRI----DIILKNASPSDHRRLADNE-PLLMKLAKLESIRVLE--AGEEAPM 863
Cdd:PRK14900 740 AAEAAFRPVLGIIDAVRNIRGEMGIPWKVKLgaqaPVEIAVADPALRDLLQAGElARVHRVAGVEGSRLVVaaATAPAPQ 819
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 864 SATALVGDMEVLVPMAGLIDKSAELGRLDKEIQRLEGEVKRVGGKLSNEGFVAKAPADVIEKERAKLAEAEQALAKLAEQ 943
Cdd:PRK14900 820 SAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDRARAEELREKRGKLEAH 899
|
....*
gi 9950009 944 RQKIA 948
Cdd:PRK14900 900 RAMLS 904
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
11-944 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 841.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 11 ETSWYETWESNDYFAPSGE--GQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVV 88
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDrgGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVV 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 89 ERQLGAQGVSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGKR 168
Cdd:PLN02943 146 EKMLASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSY 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 169 LVNWDTKLHTAISDLEVENHDEKGHLWHLRYPLVNGAKtseglDYLVVATTRPETLLGDAAVAVHPEDERYAKLIGQFAE 248
Cdd:PLN02943 226 MVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGSE-----DFLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMAI 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 249 LPIV-GRHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKnaavlaqaqvfhlDGSVNPNldpslpq 327
Cdd:PLN02943 301 VPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNK-------------DGTLNEV------- 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 328 syAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLTDQWYVSTKPLAEDAIAAVEDGRIQFVPKQYE 407
Cdd:PLN02943 361 --AGLYWFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERFE 438
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 408 NMYFSWMRDIQDWCISRQLWWGHRIPAWY----DEAGNVYVGRDEVEV--RTKHKLGNEAELRQDEDVLDTWFSSGLWTF 481
Cdd:PLN02943 439 KIYNHWLSNIKDWCISRQLWWGHRIPVWYivgkDCEEDYIVARSAEEAleKAREKYGKDVEIYQDPDVLDTWFSSALWPF 518
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 482 STLGWPQ-QTEFLKTFHPTDVLVTGFDIIFFWVARMIMLTMHLvknpdgTPQIPFKTVYVHGLVRDGQGQKMSKSKGNVL 560
Cdd:PLN02943 519 STLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEF------TGTVPFSYVYLHGLIRDSQGRKMSKTLGNVI 592
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 561 DPLDIvdgidldtllqkrtsgmmqpklaekiakqtraefpegIASYGTDALRFTFcSLASTGRDIKFDMGRVEGFRNFCN 640
Cdd:PLN02943 593 DPLDT-------------------------------------IKEFGTDALRFTL-ALGTAGQDLNLSTERLTSNKAFTN 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 641 KIWNAANFVIENTDGQDTGVNGEPVELSSVD------------RWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDE 708
Cdd:PLN02943 635 KLWNAGKFVLQNLPSQSDTSAWEHILACKFDkeesllslplpeCWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSD 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 709 YCAWYLELVKPVLWDENAPIERQRgTRRTLIRVLETALRLAHPFMPFITEEIWQRIKgqagKEGPTLMLQPWPVADEGRi 788
Cdd:PLN02943 715 FADWYIEASKTRLYHSGDNSALSR-AQAVLLYVFENILKLLHPFMPFVTEELWQALP----YRKEALIVSPWPQTSLPK- 788
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 789 DAAAEGDIEWVKALMLGVRQIRGEMNISMAKRIDIILKnASPSDHRRLADNEPLLMKLAKLE--SIRVLEAGEEAPMSAT 866
Cdd:PLN02943 789 DLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIV-ASAEVIEYISKEKEVLALLSRLDlqNVHFTDSPPGDANQSV 867
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 867 ALVGD--MEVLVPMAGLIDKSAELGRLDKEIQRLEGEVKRVGGKLSNEGFVAKAPADVIEKERAKLAEAEQALaKLAEQR 944
Cdd:PLN02943 868 HLVASegLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAEAEEKI-KLTKNR 946
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-949 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 828.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 1 MDKTYQPHAIETSWYETWESNDYFA--PSGEGQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTD 78
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGadAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 79 HAGIATQMVVERQL-GAQGVSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRL 157
Cdd:PLN02381 176 HAGIATQVVVEKKLmRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 158 HEDGLIYRGKRLVNWDTKLHTAISDLEVENHDEK----------------GHLWHLRYPLvngaktSEGLDYLVVATTRP 221
Cdd:PLN02381 256 YKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKertllkvpgydkpvefGVLTSFAYPL------EGGLGEIVVATTRI 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 222 ETLLGDAAVAVHPEDERYAKLIGQFAELPIVGRHIPIIAD-EYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDK 300
Cdd:PLN02381 330 ETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTD 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 301 naavlaqaqvfhlDGSVNPNLDpslpQSYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLTDQWY 380
Cdd:PLN02381 410 -------------DGKINSNGG----SEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWF 472
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 381 VSTKPLAEDAIAAVEDG---RIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWY-----DEAGNV-------YVG 445
Cdd:PLN02381 473 VNCSSMAKQALDAAIDGenkKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYvtledDQLKELgsyndhwVVA 552
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 446 RDEVEVR---TKHKLGNEAELRQDEDVLDTWFSSGLWTFSTLGWPQQTEFLKTFHPTDVLVTGFDIIFFWVARMIMLTMH 522
Cdd:PLN02381 553 RNESDALleaSQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQ 632
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 523 LvknpdgTPQIPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDGIDLDTLLQKRTSGMMQPKLAEKIAKQTRAEFPEG 602
Cdd:PLN02381 633 L------GGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKDFPNG 706
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 603 IASYGTDALRFTFCSLASTGRDIKFDMGRVEGFRNFCNKIWNAANFVIENTDGQDTGVNGEPVE-LSSVDRWIISQLQRT 681
Cdd:PLN02381 707 IAECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVEtMPFSCKWILSVLNKA 786
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 682 EQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLELVKPVLWDENAPIERQRG-TRRTLIRVLETALRLAHPFMPFITEEI 760
Cdd:PLN02381 787 ISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNPEFASERAaAQDTLWICLDTGLRLLHPFMPFVTEEL 866
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 761 WQRI---KGQAGKEgpTLMLQPWPVADEGRIDAAAEGDIEWVKALMLGVRQIRGEMNISMA-KRIDIILKNASPSDHRRL 836
Cdd:PLN02381 867 WQRLpqpKDHTRKD--SIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLRAEVLEKQKnERLPAFALCRNQEIAAII 944
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 837 ADNEPLLMKLAKLESIRVLEAGEEAPM--SATALVG-DMEVLVPMAGLIDKSAELGRLDKEIQRLEGEVKRVGGKLSNEG 913
Cdd:PLN02381 945 KSHQLEILTLANLSSLKVLLSENDAPPagCAFENVNeNLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASG 1024
|
970 980 990
....*....|....*....|....*....|....*.
gi 9950009 914 FVAKAPADVIEKERAKLAEAEQALAKLAEQRQKIAA 949
Cdd:PLN02381 1025 YKEKVPANIQEEDARKLTKLLQELEFFEKESKRLEA 1060
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-628 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 749.62 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 13 SWYETWESNDYFAPSGEG----QPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVV 88
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKrkgkPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 89 ERQLGAQG-VSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGK 167
Cdd:pfam00133 81 EKKLGIKEkKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 168 RLVNWDTKLHTAISDLEVENHDEKGHLWHLRYPLVNGAKTSegldyLVVATTRPETLLGDAAVAVHPE------------ 235
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGAS-----LVIWTTTPWTLPGNTAVAVNPEfdyvitgegyil 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 236 -------------------DERYAKLIGQFAELPIVGRHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLIN 296
Cdd:pfam00133 236 aeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVIN 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 297 IFDKNAavlaqaqvfhldgsvnpNLDPSLPQsYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLT 376
Cdd:pfam00133 316 PVDDDG-----------------TFTEEAPD-FQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRAT 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 377 DQWYVSTKPLAEDAIAAVEDgrIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEA-GNVYV---------GR 446
Cdd:pfam00133 378 PQWFVRMDELADQALEAVEK--VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDtEEVVCrgelfelvaGR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 447 DEVEVR-------TKHKLGNEAE-LRQDEDVLDTWFSSGLWTFSTLGWP-QQTEFLKTFHPTDVLVTGFDIIFFWVARMI 517
Cdd:pfam00133 456 FEEEGSikwlhreAKDKLGYGKGtLEQDEDVLDTWFSSGSWPFSTLGWPfVNTEEFKKFFPADMLLEGSDQTRGWFYRMI 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 518 MLTMHLVKNPdgtpqiPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDgidldtllqkrtsgmmqpklaekiakqtra 597
Cdd:pfam00133 536 MLSTALTGSV------PFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID------------------------------ 579
|
650 660 670
....*....|....*....|....*....|.
gi 9950009 598 efpegiaSYGTDALRFTFCSlASTGRDIKFD 628
Cdd:pfam00133 580 -------KYGADALRLWLAN-SDYGRDINLS 602
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
32-627 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 584.21 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 32 PYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVVERQLGAQGVSRHDLGREKFLEKV 111
Cdd:cd00817 2 VFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHDLGREEFLEKC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 112 WEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGKRLVNWDTKLHTAISDLEVenhdek 191
Cdd:cd00817 82 WEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV------ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 192 ghlwhlryplvngaktsegldylvvattrpetllgdaavavhpederyakligqfaelpivgrhipiiadeyvdrefgtg 271
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 272 cvkitpahdfndyevgkrhdlplinifdknaavlaqaqvfhldgsvnpnldpslpqsyagmdrfaarkaivaefeamgll 351
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 352 ekvddhalkvpkGDRSGTVIEPWLTDQWYVSTKPLAEDAIAAVEDGRIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHR 431
Cdd:cd00817 156 ------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHR 223
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 432 IPAWYDEAGN-VYVGRDEVEVRTKHK-----LGNEAELRQDEDVLDTWFSSGLWTFSTLGWPQQTEFLKTFHPTDVLVTG 505
Cdd:cd00817 224 IPAWYCKDGGhWVVAREEDEAIDKAApeacvPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTG 303
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 506 FDIIFFWVARMIMLTMHLvknpdgTPQIPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDGidldtllqkrtsgmmqp 585
Cdd:cd00817 304 HDIIFFWVARMIMRGLKL------TGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDG----------------- 360
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 9950009 586 klaekiakqtraefpegiasYGTDALRFTFCSLASTGRDIKF 627
Cdd:cd00817 361 --------------------YGADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-867 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 567.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 1 MDKTYQPHAIETSWYETWESNDYFA--PSGEGQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTD 78
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKfdPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 79 HAGIATQMVVERQLGaqgVSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDglsEAVK---EAFV 155
Cdd:PRK13208 86 DNGLPTERKVEKYYG---IRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISP---EYRRisqKSFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 156 RLHEDGLIYRGKRLVNWDTKLHTAISDLEVENHDEKGHLWHLRYPLVNGaktseglDYLVVATTRPETLLGDAAVAVHPE 235
Cdd:PRK13208 160 DLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDG-------EEIEIATTRPELLPACVAVVVHPD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 236 DERYAKLIGQFAELPIVGRHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKnaavlaqaqvfhlDG 315
Cdd:PRK13208 233 DERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDE-------------DG 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 316 SVNPNLDPslpqsYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLTDQWYVSTKPLAEDAIAAVE 395
Cdd:PRK13208 300 RMTEAAGK-----LAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGK 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 396 dgRIQFVP----KQYENmyfsWMRDIQ-DWCISRQLWWGHRIPAWY-DEAGNVYVG----------RDEVEVRTKHKLGN 459
Cdd:PRK13208 375 --EINWYPehmrVRLEN----WIEGLNwDWCISRQRYFGTPIPVWYcKDCGHPILPdeedlpvdptKDEPPGYKCPQCGS 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 460 EaELRQDEDVLDTWFSSGL-WTFSTlGWPQQTEFLKTFHPTDVLVTGFDIIFFW----VARMIMLTmhlvknpdGTpqIP 534
Cdd:PRK13208 449 P-GFEGETDVMDTWATSSItPLIVT-GWERDEDLFEKVFPMDLRPQGHDIIRTWlfytILRAYLLT--------GK--LP 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 535 FKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVdgidldtllqkrtsgmmqpklaEKiakqtraefpegiasYGTDALRFT 614
Cdd:PRK13208 517 WKNIMISGMVLDPDGKKMSKSKGNVVTPEELL----------------------EK---------------YGADAVRYW 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 615 FCSlASTGRDIKFDMGRVEGFRNFCNKIWNAANFVIENTDGQDTgvnGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRF 694
Cdd:PRK13208 560 AAS-ARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLHFSADPEP---DKAEVLEPLDRWILAKLAKVVEKATEALENYDF 635
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 695 DLAAQALYEFIWDEYCAWYLELVKPVLWDENAPiERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRIKGQagkegpT 774
Cdd:PRK13208 636 AKALEEIESFFWHVFCDDYLELVKSRAYGEDEE-EEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG------S 708
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 775 LMLQPWPVADEGRIDAAAEGDIEWVKALMLGVRQIRGEMNISMAKRIDIILKNAsPSDHRRLADNEPLLMKLAKLESIRV 854
Cdd:PRK13208 709 VHRASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVYG-PADLELLEAAEEDLKAAGNIEELEL 787
|
890
....*....|...
gi 9950009 855 LEAGEEAPMSATA 867
Cdd:PRK13208 788 VEGDPELEVEIIA 800
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
39-876 |
7.08e-120 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 387.90 E-value: 7.08e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 39 PPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTD-HaG--IATQmvVERQLGAQGVSRHDLGREKFLEK----V 111
Cdd:COG0060 54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-GlpIELK--VEKELGIKKKDIEKVGIAEFREKcreyA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 112 WEW-KEQsggniTRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGKRLVNWDTKLHTAISDLEVENHDE 190
Cdd:COG0060 131 LKYvDEQ-----REDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDV 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 191 KGHLWHLRYPLVNGAKTSEGLD-YLVVATTRPETLLGDAAVAVHPE----------DERY-------------------- 239
Cdd:COG0060 206 TSPSIYVKFPVKDEKALLLLEDaYLVIWTTTPWTLPANLAVAVHPDidyvlvevtgGERLilaealveavlkelgiedye 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 240 -------AKLIGQ-----FAELPIVGRHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKNAavlaq 307
Cdd:COG0060 286 vlatfkgAELEGLryehpFYYVVGYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDG----- 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 308 aqVFhldgsvnpnlDPSLPQsYAGMDRFAARKAIVAEFEAMGLLEKVDDHALKVPKGDRSGT-VIepWL-TDQWYVSTKP 385
Cdd:COG0060 361 --RF----------TEEAPL-FAGLFVKDANPAIIEDLKERGALLAREKITHSYPHCWRCKTpLI--YRaTPQWFISMDK 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 386 LAEDAIAAVEDgrIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWY-DEAGNVYV---------------GRDEV 449
Cdd:COG0060 426 LRDRALEAIEK--VNWIPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVcEDCGELHRteevigsvaelleeeGADAW 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 450 EVRTKHK--LGNE-------AELRQDEDVLDTWFSSGLWTFSTLgwpQQTEflKTFHPTDVLVTGFDII---FFwvarmi 517
Cdd:COG0060 504 FELDLHRpfLDETlkcpkcgGTMRRVPDVLDVWFDSGSMHFAVL---ENRE--ELHFPADFYLEGSDQTrgwFY------ 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 518 mlTMHL----VKNpdgtpQIPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDgidldtllqkrtsgmmqpklaekiak 593
Cdd:COG0060 573 --SSLLtstaLFG-----RAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVID-------------------------- 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 594 qtraefpegiaSYGTDALRFTFCSlASTGRDIKFDMGRVEGFRNFCNKIWNAANFVIENTDGQD-TGVNGEPVELSSVDR 672
Cdd:COG0060 620 -----------KYGADILRLWVAS-SDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLDDFDpAEDAVPYEDLPELDR 687
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 673 WIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLELVKPVLW-DENAPIERqRGTRRTLIRVLETALRLAHP 751
Cdd:COG0060 688 WILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYtEAADSLDR-RAAQTTLYEVLETLVRLLAP 766
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 752 FMPFITEEIWQRIKgqaGKEGPTLMLQPWPVADEGRIDAAAEGDIEWvkalmlgVRQIRGEMNIS-----MAKRI----- 821
Cdd:COG0060 767 ILPFTAEEIWQNLP---GEAEESVHLADWPEVDEELIDEELEAKWDL-------VREVRSAVLKAleaarKEKLIrqple 836
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*
gi 9950009 822 DIILKNASPSDHRRLADNEPLLMKLAKLESIRVLEAGEEAPMSATALVGDMEVLV 876
Cdd:COG0060 837 AAVVLYADEELAAALESLGDLLAEELNVSEVELVDDAEDLGKDALKALDVEGISV 891
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
627-764 |
5.24e-65 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 214.34 E-value: 5.24e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 627 FDMGRVEGFRNFCNKIWNAANFVIENTDGQDTGvNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIW 706
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEP-EEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFW 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 9950009 707 DEYCAWYLELVKPVLWDENApiERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRI 764
Cdd:cd07962 80 NDFCDWYLELVKPRLYGEDE--EEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
32-627 |
2.31e-62 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 213.82 E-value: 2.31e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 32 PYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVVERQLGAQGVSRHdlgREKFLEKV 111
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW---IEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 112 WEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFvrlhedgliyrgKRLVNwdtklhtaisdlevenhdek 191
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIF------------SRLYE-------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 192 ghlwhlryplvngaktsEGLdylvvattrpetllgdaavavhpederyakligqfaelpIVGRHIPIIAdeyvdrefgtg 271
Cdd:cd00668 126 -----------------KGL---------------------------------------IYRGTHPVRI----------- 138
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 272 cvkitpahdfndyevgkrhdlplinifdknaavlaqaqvfhldgsvnpnldpslpqsyagmdrfaarkaivaefeamgll 351
Cdd:cd00668 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 352 ekvddhalkvpkgdrsgtviepwlTDQWYVSTKPLAEDAIAAVEdgRIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHR 431
Cdd:cd00668 139 ------------------------TEQWFFDMPKFKEKLLKALR--RGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTP 192
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 432 IPawydeagnvyvgrdevevrtkhklgneaelrqdEDVLDTWFSSGLWTFSTLGWPQQTEFLKTFHPTDVLVTGFDIIFF 511
Cdd:cd00668 193 LP---------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRG 239
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 512 WVARMIMLTMHLVKnpdgtpQIPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVdgidldtllqkrtsgmmqpklaEKi 591
Cdd:cd00668 240 WANFWITMLVALFG------EIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV----------------------EK- 290
|
570 580 590
....*....|....*....|....*....|....*.
gi 9950009 592 akqtraefpegiasYGTDALRFTFCSLASTGRDIKF 627
Cdd:cd00668 291 --------------YGADALRYYLTSLAPYGDDIRL 312
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
18-814 |
9.96e-61 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 224.27 E-value: 9.96e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 18 WESNDYF---APSGEGQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVVERQLGA 94
Cdd:PLN02843 16 WEENQVYkrvSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVLQSLDQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 95 QgvSRHDLGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGKRLVNWDT 174
Cdd:PLN02843 96 E--ARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVHWSP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 175 KLHTAISDLEVENhdEKGHLWHLRY---PLVNGAKTS-----EGLDYLVVA--TTRPETLLGDAAVAVHP---------- 234
Cdd:PLN02843 174 SSRTALAEAELEY--PEGHVSKSIYvafPVVSPSETSpeeleEFLPGLSLAiwTTTPWTMPANAAVAVNDklqysvvevq 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 235 ---EDERY------------------------AKLIGQFAEL-----------------------PIVGRHIPIIAD-EY 263
Cdd:PLN02843 252 sfsEDESTsggnkkkrpgnvlkeqqklflivaTDLVPALEAKwgvklvvlktfpgsdlegcryihPLYNRESPVVIGgDY 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 264 VDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKNAAVLAQAQVFhldgsvnpnldpslpqsyAGMDRFAA-RKAIV 342
Cdd:PLN02843 332 ITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQF------------------SGLSVLGEgNAAVV 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 343 AEFEAMGLLEKVDDHALKVPKGDRSGtviEPWL---TDQWYVSTKPLAEDAIAAVEdgRIQFVPKQYENMYFSWMRDIQD 419
Cdd:PLN02843 394 EALDEAGSLLMEEAYGHKYPYDWRTK---KPTIfraTEQWFASVEGFRQAALDAID--KVKWIPAQGENRIRAMVSGRSD 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 420 WCISRQLWWGHRIPAWYD-EAGNVYVGRDEVE-----VRTK---------------HKLGNEA-ELRQDEDVLDTWFSSG 477
Cdd:PLN02843 469 WCISRQRTWGVPIPVFYHvETKEPLMNEETIAhvksiVAQKgsdawwymdvedllpEKYRDKAsDYEKGTDTMDVWFDSG 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 478 lwtFSTLGWPQQTEFLKtfHPTDVLVTGFDIIFFWVaRMIMLTMHLVKNpdgtpQIPFKTVYVHGLVRDGQGQKMSKSKG 557
Cdd:PLN02843 549 ---SSWAGVLGSREGLS--YPADLYLEGSDQHRGWF-QSSLLTSVATKG-----KAPYKSVLTHGFVLDEKGFKMSKSLG 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 558 NVLDPLDIVDGidldtllqkrtsgmmqpklaEKIAKQTRAefpegiasYGTDALRFTFCSLASTGrDIKFDMGRVEGFRN 637
Cdd:PLN02843 618 NVVDPRLVIEG--------------------GKNQKQEPA--------YGADVLRLWVASVDYTG-DVLIGPQILKQMSD 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 638 FCNKIWNAANFVIENTDGQDTgVNGEPVE-LSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLEL 716
Cdd:PLN02843 669 IYRKLRGTLRYLLGNLHDWKP-DNAVPYEdLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDV 747
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 717 VKPVLWDENAPIERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRIK-GQAGKEGPTLMLQPWPVADEGRIDAAAEGD 795
Cdd:PLN02843 748 AKDRLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPfQEDGSAAESVFEAGWPTPNEEWLSFPAEDV 827
|
890
....*....|....*....
gi 9950009 796 IEWVKALmlgvrQIRGEMN 814
Cdd:PLN02843 828 DFWSLLL-----EVRDEVN 841
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-785 |
1.73e-50 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 191.80 E-value: 1.73e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 1 MDKTYQPHAIETSWYETWESNDYF-APSGEGQP--YT-IMIPPPnvTGSLHMGHGFNNAIMDALIRYRRMQGRNTLwQP- 75
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFkADEDSSKPkyYVlDMFPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVL-HPm 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 76 GTD-------HAGIATqmvverqlgaqGVsrHdlgrekflEKVWEWKeqsggNI---TRQIRRLGSSVDWSRE------- 138
Cdd:COG0495 78 GWDafglpaeNAAIKN-----------GV--H--------PAEWTYE-----NIanmRRQLKRLGLSYDWSREiatcdpe 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 139 --RFT--MddglseavkeaFVRLHEDGLIYRGKRLVNWDTKLHTAISDLEVEN-------HD-EKGHL--WHLR---Y-- 199
Cdd:COG0495 132 yyKWTqwI-----------FLQLYEKGLAYRKEAPVNWCPVDQTVLANEQVIDgrcwrcgAPvEKKELpqWFLKitdYad 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 200 PLVNGAKT------------------SEGL----------DYLVVATTRPETLLGDAAVAV---HP------EDERYAKL 242
Cdd:COG0495 201 ELLDDLDKldgwpekvktmqrnwigrSEGAevdfpvegsdEKITVFTTRPDTLFGATFMVLapeHPlvkelaTPEQNAAV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 243 --------------------------IGQFAELPIVGRHIPI-IADeYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLI 295
Cdd:COG0495 281 aafieeakkkseiertsetkektgvfTGLYAINPLTGEKIPIwIAD-YVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIK 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 296 NIFDKNAA--VLAQAQVFHLDG-SVNpnldpSlpQSYAGMDRFAARKAIVAEFEAMGLLEKvddhalkvpkgdrsgtvie 372
Cdd:COG0495 360 QVIAPEDGddPDILEEAYTGDGvLIN-----S--GEFDGLDSEEAKEAIIEWLEEKGLGKR------------------- 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 373 pwltdqwyvstkplaedaiaavedgRIQFvpkqyenmyfswmRdIQDWCISRQLWWGHRIPAWYDEAGNV---------- 442
Cdd:COG0495 414 -------------------------KVNY-------------R-LRDWLISRQRYWGEPIPIIHCEDCGVvpvpedqlpv 454
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 443 -------YVGRDE---------VEVrTKHKLGNEAelRQDEDVLDTWF-SSglwtfstlgW-------PQQTEflktfHP 498
Cdd:COG0495 455 elpedvdFDPTGGsplarapewVNV-TCPKCGGPA--RRETDTMDTFVdSS---------WyylrytdPHNDE-----AP 517
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 499 TDVlvtgfDIIFFWV------------------ARMIMLTMH---LVKNPDgtpqiPFKTVYVHGLV----RDG----QG 549
Cdd:COG0495 518 FDP-----EAANYWLpvdqyiggiehailhllyARFFTKVLRdlgLVSFDE-----PFKRLLTQGMVlevgKDGvvigGI 587
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 550 QKMSKSKGNVLDPLDIVDgidldtllqkrtsgmmqpklaekiakqtraefpegiaSYGTDALRFTFCSLASTGRDIKFDM 629
Cdd:COG0495 588 EKMSKSKGNVVDPDEIIE-------------------------------------KYGADTLRLFEMFAGPPERDLEWSD 630
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 630 GRVEGFRNFCNKIWnaaNFVIENTDgqdtGVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIwdey 709
Cdd:COG0495 631 SGVEGAYRFLNRVW---RLVVDEAE----ALKLDVADLSEADKELRRALHKTIKKVTEDIERLRFNTAIAALMELV---- 699
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9950009 710 cawylelvkpvlwdeNA--PIERQRGTRRTLIR-VLETALRLAHPFMPFITEEIWQRIkgqaGKEGpTLMLQPWPVADE 785
Cdd:COG0495 700 ---------------NAlyKAKDSGEADRAVLReALETLVLLLAPFAPHIAEELWERL----GHEG-SVADAPWPEADE 758
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
46-939 |
2.25e-50 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 192.39 E-value: 2.25e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 46 LHMGHGFNNAIMDALIRYRRMQGRNTLW-----QPGTDHAGIA--------TQMVVERQLgaQGVSRHDLgrEKFlEKVW 112
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFpmafhVTGTPILGIAeriargdpETIELYKSL--YGIPEEEL--EKF-KDPE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 113 EWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGKRLVNWDTKLHTAisdleVENHDEKG 192
Cdd:PRK12300 76 YIVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNP-----VGDHDLLD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 193 hlwhlryplvnGA------------KTSEGLdYLVVATTRPETLLGDAAVAVHPE---------DERYA----------- 240
Cdd:PRK12300 151 -----------GEepeiveytlikfEESEDL-ILPAATLRPETIFGVTNLWVNPDatyvkaevdGEKWIvskeaaeklsf 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 241 --------------KLIGQFAELPIVGRHIPIIADEYVDREFGTGCVKITPAHDFNDY----EVGKRHDL-------PLI 295
Cdd:PRK12300 219 qdrdveiieeikgsELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELldviepiPLI 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 296 -----------------NIFDKNAAVLAQA--QV----FHlDGSVNPNLDPslpqsYAGMDRFAARKAIVAEFEAMGLLE 352
Cdd:PRK12300 299 evegygefpakevveklGIKSQEDPELEEAtkEVyraeFH-KGVLKENTGE-----YAGKPVREAREKITKDLIEKGIAD 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 353 KVDDHALKvPKGDRSGT-VIEPWLTDQWYVST-----KPLAEDAIAavedgRIQFVP----KQYENMYFsWMRDiqdWCI 422
Cdd:PRK12300 373 IMYEFSNR-PVYCRCGTeCVVKVVKDQWFIDYsdpewKELAHKALD-----NMEIIPeeyrKEFENTID-WLKD---RAC 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 423 SRQLWWGHRIP-----------------AWYD-----EAGN-------------VYVGR---DEVEVRTKHKLGNEAELR 464
Cdd:PRK12300 443 ARRRGLGTRLPwdeewiieslsdstiymAYYTiahkiREYGikpeqltpeffdyVFLGKgdpEEVSKKTGIPKEILEEMR 522
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 465 QdedvldtwfssglwtfstlgwpqqtEFLkTFHPTDVLVTGFDII-----FFwvarmimlTMHLV------KNPDGtpqi 533
Cdd:PRK12300 523 E-------------------------EFL-YWYPVDWRHSGKDLIpnhltFF--------IFNHVaifpeeKWPRG---- 564
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 534 pfktVYVHGLVRDGqGQKMSKSKGNVLdPLDivdgidldtllqkrtsgmmqpklaekiakqtraefpEGIASYGTDALRF 613
Cdd:PRK12300 565 ----IVVNGFVLLE-GKKMSKSKGNVI-PLR------------------------------------KAIEEYGADVVRL 602
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 614 TFCSLASTGRDIKFDMGRVEGFRNFCNKIWNAANFVIENtdgqdtgvnGEPVELSSVDRWIISQLQRTEQEVTRQLDAFR 693
Cdd:PRK12300 603 YLTSSAELLQDADWREKEVESVRRQLERFYELAKELIEI---------GGEEELRFIDKWLLSRLNRIIKETTEAMESFQ 673
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 694 FDLAAQ-ALYEFIwdEYCAWYLELVkpvlwdENAPierqrgtRRTLIRVLETALRLAHPFMPFITEEIWQRIkgqaGKEG 772
Cdd:PRK12300 674 TRDAVQeAFYELL--NDLRWYLRRV------GEAN-------NKVLREVLEIWIRLLAPFTPHLAEELWHKL----GGEG 734
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 773 PtLMLQPWPVADEGRIDAAAEGDIEWVKALMLGVRQIRGEMNISmAKRIDIILKNAspsdhrrladnepllmklaklESI 852
Cdd:PRK12300 735 F-VSLEKWPEPDESKIDEEAELAEEYVKRLIEDIREILKVAKIK-PKKVYIYVAPD---------------------WKY 791
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 853 RVLEAGEEapmsatalVGDMEVLVPMaglIDKSAELGRLDKEIQRLEGEVKRVGGKLSNEGFVAKAPADViekERAKLAE 932
Cdd:PRK12300 792 EVLEIAAE--------NGDVKEAIKE---LMKDEELRKHGKEVAKLAQKIVKEVLKLDKEVRKLILKNID---EEEVLEE 857
|
....*..
gi 9950009 933 AEQALAK 939
Cdd:PRK12300 858 AKDFLEK 864
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
671-825 |
1.36e-44 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 157.56 E-value: 1.36e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 671 DRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLELVKPVLWDENAPIErqrgTRRTLIRVLETALRLAH 750
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR----AQTTLYEVLETLLRLLA 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9950009 751 PFMPFITEEIWQRIkgqagkegpTLMLQPWPVaDEGRIDAAAEGDIEWVKALMLGVRQIRGEMNISMAKRIDIIL 825
Cdd:pfam08264 77 PFMPFITEELWQKE---------SIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
18-828 |
3.44e-41 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 164.51 E-value: 3.44e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 18 WESNDYFAPS---GEGQP-YTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVVERQLG 93
Cdd:PLN02882 21 WSEIDAFKTQlkrTEGLPeYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 94 AQGvsRHD---LGREKFLEK--------VWEWKeqsggnitRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGL 162
Cdd:PLN02882 101 IKR--RDDvlkMGIDKYNEEcrsivtrySKEWE--------KTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 163 IYRGKRLVNWDTKLHTAISDLEV-ENH-DEKGHLWHLRYPLVNGAKTSEgldyLVVATTRPETLLGDAAVAVHPEDErYA 240
Cdd:PLN02882 171 VYKGFKVMPYSTACKTPLSNFEAgLNYkDVSDPAVMVSFPIVGDPDNAS----FVAWTTTPWTLPSNLALCVNPNFT-YV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 241 KLI------------GQFAELP-----------------------------IVG-RHIPI--------------IADEYV 264
Cdd:PLN02882 246 KVRnkytgkvyivaeSRLSALPtakpkskkgskpenaaegyevlakvpgssLVGkKYEPLfdyfsefsdtafrvVADDYV 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 265 DREFGTGCVKITPAHDFNDYEVGKRHDL-----PLINIFDKNAAVLAQAQVFhldgsvnpnldpslpqsyAGMDRFAARK 339
Cdd:PLN02882 326 TDDSGTGVVHCAPAFGEDDYRVCLANGIiekggNLPVPVDDDGCFTEKVTDF------------------SGRYVKDADK 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 340 AIVAEFEAMGLLEKVDDHALKVPKGDRSGTVIEPWLTDQWYVSTKPLAEDAIAAVEdgRIQFVPKQY-ENMYFSWMRDIQ 418
Cdd:PLN02882 388 DIIAAIKAKGRLVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNK--QTYWVPDYVkEKRFHNWLENAR 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 419 DWCISRQLWWGHRIPAWYDEAGN--VYVG-RDEVEVRTKHKL-----------------GNE-AELRQDEDVLDTWFSSG 477
Cdd:PLN02882 466 DWAVSRSRFWGTPLPIWISDDGEevVVIGsIAELEKLSGVKVtdlhrhfidhitipssrGPEfGVLRRVDDVFDCWFESG 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 478 LWTFSTLGWP--QQTEFLKTFhPTDVLVTGFDIIFFWVARMIMLTMHLVKNPdgtpqiPFKTVYVHGLVRDGQGQKMSKS 555
Cdd:PLN02882 546 SMPYAYIHYPfeNKELFEKNF-PADFVAEGLDQTRGWFYTLMVLSTALFDKP------AFKNLICNGLVLAEDGKKMSKS 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 556 KGNVLDPLDIVDgidldtllqkrtsgmmqpklaekiakqtraefpegiaSYGTDALR-FTFCSLASTGRDIKFdmgRVEG 634
Cdd:PLN02882 619 LKNYPDPNEVID-------------------------------------KYGADALRlYLINSPVVRAEPLRF---KEEG 658
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 635 FRNFCNKI----WNAANFVIENTD-------GQDTGVNGEPVELSS--VDRWIISQLQRTEQEVTRQLDAFRFDLAAQAL 701
Cdd:PLN02882 659 VFGVVKDVflpwYNAYRFLVQNAKrleveggAPFVPLDLAKLQNSAnvLDRWINSATQSLVKFVREEMGAYRLYTVVPYL 738
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 702 YEFIwDEYCAWYLELVKPVLWDENAPIERQRGTrRTLIRVLETALRLAHPFMPFITEEIWQRIKGQAGKEGPTLMLQPWP 781
Cdd:PLN02882 739 VKFI-DNLTNIYVRFNRKRLKGRTGEEDCRTAL-STLYNVLLTSCKVMAPFTPFFTEVLYQNLRKVLPGSEESIHYCSFP 816
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|
gi 9950009 782 VADEGRIDAAAEGDIEWVKALMLGVRQIRGEMNISMA---KRIDIILKNA 828
Cdd:PLN02882 817 QVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKtplKEMVVVHPDA 866
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
39-574 |
7.13e-36 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 139.29 E-value: 7.13e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 39 PPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVVERQLGAQGVS-RHDLGREKFLEK------- 110
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKdIEKMGIAEFNAKcrefalr 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 111 -VWEWKEQsggnitrqIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRgkrlvnwdtklhtaisdlevenhd 189
Cdd:cd00818 89 yVDEQEEQ--------FQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYR------------------------ 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 190 ekghlwhlryplvngaktseglDYLVVattrpetllgdaavavhpederyakligqfaelpivgrHIPIIadeyvdrefg 269
Cdd:cd00818 137 ----------------------GYKVV--------------------------------------PWPLI---------- 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 270 tgcvkitpahdfndyevgkrhdlplinifdknaavlaqaqvfhldgsvnpnldpslpqsyagmdrfaarkaivaeFEAmg 349
Cdd:cd00818 147 ---------------------------------------------------------------------------YRA-- 149
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 350 llekvddhalkvpkgdrsgtviepwlTDQWYVSTKPLAEDAIAAVEdgRIQFVPKQYENMYFSWMRDIQDWCISRQLWWG 429
Cdd:cd00818 150 --------------------------TPQWFIRVTKIKDRLLEAND--KVNWIPEWVKNRFGNWLENRRDWCISRQRYWG 201
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 430 HRIPAWYDEAGnvyvgrDEVEVRtkhklgneaelrQDEDVLDTWFSSGLWTFSTLGWPQQTEFLKTFHPTDVLVTGFDII 509
Cdd:cd00818 202 TPIPVWYCEDC------GEVLVR------------RVPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQT 263
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9950009 510 FFWVARMIMLTMHLVKNPdgtpqiPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDGIDLDTL 574
Cdd:cd00818 264 RGWFYSLLLLSTALFGKA------PYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADAL 322
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
18-860 |
3.70e-35 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 145.11 E-value: 3.70e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 18 WESNDYFAPSGE----GQPYTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVVERQLG 93
Cdd:PTZ00427 85 WKSIDAFNTSNKlaknKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKENN 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 94 AQgvSRHD---LGREKFLEKVWEWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGKRLV 170
Cdd:PTZ00427 165 IN--KKEDilkMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVM 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 171 NWDTKLHTAISDLE-------------------------VEN----HDEKGHLWHLRYPLVN---------GAKTSEGLD 212
Cdd:PTZ00427 243 PYSCKCNTPISNFElnlnykdtpdpsiiisfvlcsdfpkVEEecniEEDKQLLGEKYSVLYNnkrensnngNNNSTNNVC 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 213 Y-----LVVATTRPETLLGDAAVAV----------HPEDERYA---------------------KLIGQF--AEL----- 249
Cdd:PTZ00427 323 YaqhseILAWTTTPWTLPSNLALCVnehftylrihHVKSNRVVivgecrlewimkelkwnvedlKIVNRFkgKELkglry 402
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 250 -PIVG----------RHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDL--PLINIF----DKNAAVLAQAQVfh 312
Cdd:PTZ00427 403 kPLFTnfyekynfkeRAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidPEKNIFidplDANGYFTNEVEE-- 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 313 LDGSVNPNLDPSLPQSYAGMDRFAARKAIVAEFeamgllekvddhalkvPKGDRSGTVIEPWLTDQWYV----STKPLAE 388
Cdd:PTZ00427 481 VQNLYIKEADNVIKKKLKNENRLLSNNTIVHSY----------------PFCWRSDTPLIYRAIPAWFIrvsnSTNELVK 544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 389 DaiaaveDGRIQFVPKQY-ENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRDEVE----------------- 450
Cdd:PTZ00427 545 N------NETTYWIPAHIkEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESIKhleelsgvknindlhrh 618
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 451 ----VRTKHKLGNE-AELRQDEDVLDTWFSSGLWTFSTLGWPQQTE---FLKTFhPTDVLVTGFDIIFFWVARMIMLTMH 522
Cdd:PTZ00427 619 fidhIEIKNPKGKTyPKLKRIPEVFDCWFESGSMPYAKVHYPFSTEkedFHKIF-PADFIAEGLDQTRGWFYTLLVISTL 697
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 523 LVKnpdgtpQIPFKTVYVHGLVRDGQGQKMSKSKGNVLDPLDIVDgidldtllqkrtsgmmqpklaekiakqtraefpeg 602
Cdd:PTZ00427 698 LFD------KAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILD----------------------------------- 736
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 603 iaSYGTDALR-FTFCSLASTGRDIKF-DMGRVEGFRNFCNKIWNAANFV------IENTDGQDTGVNGEPVELSS--VDR 672
Cdd:PTZ00427 737 --KYGADSLRlYLINSVAVRAENLKFqEKGVNEVVKSFILPFYHSFRFFsqevtrYECLNKKQFLFNTDYIYKNDniMDQ 814
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 673 WIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIwDEYCAWYLELVKpvlwdenapiERQRGT--RRTLIRVLETALRLAH 750
Cdd:PTZ00427 815 WIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFI-ENLTNWYIRLNR----------DRMRGSlgEENCLQSLCTTYRTLH 883
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 751 -------PFMPFITEEIWQRIKgQAGKEGPTLMLQPWPVADEGRIDaaaEGDI-EWVKALMLgvRQIRGEMNIS------ 816
Cdd:PTZ00427 884 lftvlmaPFTPFITEYIYQQLR-RVKSTNEHNENNETGNTKEGDLN---RGVIhKSVHFIML--PQVDEKYIIDyeiiel 957
|
970 980 990 1000
....*....|....*....|....*....|....*....|....
gi 9950009 817 MAKRIDIILKNASPSDHRRLADNEPllmklakLESIRVLEAGEE 860
Cdd:PTZ00427 958 IEKMKDVILLGRVLRERRKVASKKP-------LKSITILHPNES 994
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
636-802 |
4.40e-32 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 123.43 E-value: 4.40e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 636 RNFCNKIWNAANF-VIE-NTDGQDTGVNGEPVELSSV-DRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIwDEYCAW 712
Cdd:cd07961 11 RKVLLPLWNAYRFfVTYaNLDGFDPGKDDDAVASLNVlDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI-DELTNW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 713 YLELVKPVLWDENAPIERQrGTRRTLIRVLETALRLAHPFMPFITEEIWQRIKGQAGKEGPTLMLQPWPVADEGRIDAAA 792
Cdd:cd07961 90 YIRRNRKRFWGEEGDDDKL-AAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPESVHLLDWPEVDESLIDEEL 168
|
170
....*....|
gi 9950009 793 EGDIEWVKAL 802
Cdd:cd07961 169 EEAMELVREI 178
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
5-786 |
4.20e-31 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 131.87 E-value: 4.20e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 5 YQPHAIETSWYETWESNDYF-AP----SGEGQPYTI-MIPPPNVTGsLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTD 78
Cdd:PLN02563 80 YPFHEIEPKWQRYWEENRTFrTPddvdTSKPKFYVLdMFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWD 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 79 HAGI-ATQMVVErqlgaqgVSRHDlgrekflekvwewKEQSGGNITR---QIRRLGSSVDWSRERFTMDDGLSEAVKEAF 154
Cdd:PLN02563 159 AFGLpAEQYAIE-------TGTHP-------------KITTLKNIARfrsQLKSLGFSYDWDREISTTEPEYYKWTQWIF 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 155 VRLHEDGLIYRGKRLVNWDTKLHTAISDLEVEN--HDEKGH--------LWHLR-------------------------- 198
Cdd:PLN02563 219 LQLLKRGLAYQAEVPVNWCPALGTVLANEEVVDglSERGGHpvirkpmrQWMLKitayadrlledlddldwpesikemqr 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 199 ------------YPLVNGAKTSEGLDyLVVATTRPETLLGDAAVAVHPED---------------ERYAKL--------- 242
Cdd:PLN02563 299 nwigrsegaeldFSVLDGEGKERDEK-ITVYTTRPDTLFGATYLVVAPEHpllsslttaeqkeavEEYVDAasrksdler 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 243 -----------IGQFAELPIVGRHIPIIADEYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIFDKNAAVLAQAQVF 311
Cdd:PLN02563 378 telqkektgvfTGSYAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDDAEKA 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 312 HLDGSVNPNlDPSLPQSYAGMDRFAARKAIVAEFEAMGLLEKvddhalkvpkgdrsgtviepwltdqwyvstkplaedai 391
Cdd:PLN02563 458 YTGEGVIVN-SSSSGLDINGLSSKEAAKKVIEWLEETGNGKK-------------------------------------- 498
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 392 aavedgRIQFvpkqyenmyfswmrDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRDEVEVR-TKHKLGN-------EAEL 463
Cdd:PLN02563 499 ------KVNY--------------KLRDWLFARQRYWGEPIPVVFLEDSGEPVPVPESDLPlTLPELDDftptgtgEPPL 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 464 RQDEDVLDTWF-SSGLW----TFSTLGW------------PQQTEFL------KTFHPTDVLVTGFD--IIFFWVARM-- 516
Cdd:PLN02563 559 AKAVSWVNTVDpSSGKParreTNTMPQWagscwyylrfmdPKNSNALvdkekeKYWMPVDLYVGGAEhaVLHLLYARFwh 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 517 -IMLTMHLVKNPDgtpqiPFKTVYVHGLV---------RDGQGQKMSKSKGNVLDPLD--IVDGIDL----DTLLQKRTS 580
Cdd:PLN02563 639 kVLYDIGVVSTKE-----PFQCLVNQGMIlgeveytafKDSDGEYVSADTADRLGELQqeKIPEEKViksgDSFVLKDDP 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 581 GMMQPKLAEKIAKqTRAEF--PEGIAS-YGTDALRFtFCSLASTGRDIK-FDMGRVEGFRNFCNKIWNaanfVIENTDGQ 656
Cdd:PLN02563 714 SIRLIARAHKMSK-SRGNVvnPDDVVSeYGADSLRL-YEMFMGPLRDSKtWSTSGVEGVHRFLGRTWR----LVVGAPLP 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 657 DTGVN-GEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYcAWylelvkpvlwdENAPIErqrgtr 735
Cdd:PLN02563 788 DGSFRdGTVVTDEEPSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFTNAAY-KW-----------DKVPRE------ 849
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|.
gi 9950009 736 rtlirVLETALRLAHPFMPFITEEIWQRIkgqaGKEGpTLMLQPWPVADEG 786
Cdd:PLN02563 850 -----AIEPFVLLLSPYAPHLAEELWFRL----GHSN-SLAYEPWPEANPS 890
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
883-948 |
1.29e-21 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 89.25 E-value: 1.29e-21
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9950009 883 DKSAELGRLDKEIQRLEGEVKRVGGKLSNEGFVAKAPADVIEKERAKLAEAEQALAKLAEQRQKIA 948
Cdd:pfam10458 1 DVEKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKLG 66
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
641-802 |
2.03e-20 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 89.51 E-value: 2.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 641 KIWNAANFVIENTDGQDTGVNGEPVE-LSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYCAWYLELVKP 719
Cdd:cd07960 15 KIRNTFRFLLGNLNDFDPAKDAVPYEeLLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDIIKD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 720 VLWDENAPIERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRIKGQAGKEgpTLMLQPWPVADEGRIDAAAEGDIEWV 799
Cdd:cd07960 95 RLYCDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEE--SVFLEDWPELPEEWKDEELEEKWEKL 172
|
...
gi 9950009 800 KAL 802
Cdd:cd07960 173 LAL 175
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
398-762 |
1.73e-18 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 89.94 E-value: 1.73e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 398 RIQfvPKQYENMYFSWMRD-IQDWCISRQ-LWWGHRIPAwyDEAGNVYVgrdevevrtkhklgneaelrqdedvldtWFS 475
Cdd:PRK11893 180 FIQ--PASRRNEVISFVKSgLKDLSISRTnFDWGIPVPG--DPKHVIYV----------------------------WFD 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 476 SGLWTFSTLGWPQQTEFL----KTFHPTDVLVTGFDIIFF----WVArmiMLtMHLvknpdGTPQipFKTVYVHG-LVRD 546
Cdd:PRK11893 228 ALTNYLTALGYPDDEELLaelfNKYWPADVHLIGKDILRFhavyWPA---FL-MAA-----GLPL--PKRVFAHGfLTLD 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 547 GQgqKMSKSKGNVLDPLDIVDgidldtllqkrtsgmmqpklaekiakqtraefpegiaSYGTDALRFTFCSLASTGRDIK 626
Cdd:PRK11893 297 GE--KMSKSLGNVIDPFDLVD-------------------------------------EYGVDAVRYFLLREIPFGQDGD 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 627 FDMGRVEGFRN--FCNKIWNAANFVIENTDGQDTGVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEF 704
Cdd:PRK11893 338 FSREAFINRINadLANDLGNLAQRTLSMIAKNFDGKVPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILAL 417
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 9950009 705 IwdeYCAW-YLELVKPVLWDENAPiERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQ 762
Cdd:PRK11893 418 V---RAANkYIDEQAPWSLAKTDP-ERLATVLYTLLEVLRGIAVLLQPVMPELAAKILD 472
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
412-762 |
2.63e-18 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 89.40 E-value: 2.63e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 412 SWMRD-IQDWCISRQLWWGHRIPawyDEAGNV-YVgrdevevrtkhklgneaelrqdedvldtWF-------SSglwtfs 482
Cdd:COG0143 217 SWLKEgLQDLSISRDFDWGIPVP---GDPGKVfYV----------------------------WFdaligyiSA------ 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 483 TLGWPQQT-------EFLKTFHPTDVLVTGFDIIFF----WVArMIM-LTMHLVKNpdgtpqipfktVYVHG--LVRdgq 548
Cdd:COG0143 260 TKGYADDRglpedfeKYWPAPDTELVHFIGKDIIRFhaiiWPA-MLMaAGLPLPKK-----------VFAHGflTVE--- 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 549 GQKMSKSKGNVLDPLDIVDgidldtllqkrtsgmmqpklaekiakqtraefpegiaSYGTDALRFTFCSLASTGRDIKFD 628
Cdd:COG0143 325 GEKMSKSRGNVIDPDDLLD-------------------------------------RYGPDALRYYLLREVPFGQDGDFS 367
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 629 mgrVEGFRNFCN-----KIWNAAN----FVIENTDGQdtgVnGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQ 699
Cdd:COG0143 368 ---WEDFVARVNsdlanDLGNLASrtlsMIHKYFDGK---V-PEPGELTEADEELLAEAEAALEEVAEAMEAFEFRKALE 440
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9950009 700 ALYEFI------WDEYCAWylELVKpvlwDENApiERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQ 762
Cdd:COG0143 441 EIMALAraankyIDETAPW--KLAK----DEDP--ERLATVLYTLLEALRILAILLKPFLPETAEKILE 501
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
34-173 |
3.99e-18 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 86.53 E-value: 3.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 34 TIMIPPPNvtGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGI-ATQMVVERQLGAQgvsrhdlgrekflekvw 112
Cdd:cd00812 5 LVMFPYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLpAENAAIKIGRDPE----------------- 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9950009 113 EWKEQSGGNITRQIRRLGSSVDWSRERFTMDDGLSEAVKEAFVRLHEDGLIYRGKRLVNWD 173
Cdd:cd00812 66 DWTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC 126
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
631-753 |
2.14e-16 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 76.01 E-value: 2.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 631 RVEGFRNFCNKIWNAANFVIENTDGqdTGVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWDEYc 710
Cdd:cd07375 3 RLKQARAFLNRLYRLLSFFRKALGG--TQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNELN- 79
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 9950009 711 aWYLELVKPVLWDEnapiERQRGTRRTLIRVLETALRLAHPFM 753
Cdd:cd07375 80 -WYLDELKPALQTE----ELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
659-764 |
5.34e-15 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 71.85 E-value: 5.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 659 GVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQ-ALYEFiwDEYCAWYLELVKPvlwdenapierqRGTRRT 737
Cdd:cd07959 25 ETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKeGLYEL--QNDLDWYRERGGA------------GMNKDL 90
|
90 100
....*....|....*....|....*..
gi 9950009 738 LIRVLETALRLAHPFMPFITEEIWQRI 764
Cdd:cd07959 91 LRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
482-803 |
1.39e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 77.92 E-value: 1.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 482 STLGWPQQ-TEFLKTFHPTDVLVTGFDII-F---FWVarmIMLtMHLvknpdGTPqiPFKTVYVHG--LVRDGqgqKMSK 554
Cdd:PRK12267 237 TALGYGSDdDELFKKFWPADVHLVGKDILrFhaiYWP---IML-MAL-----GLP--LPKKVFAHGwwLMKDG---KMSK 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 555 SKGNVLDPLDIVDgidldtllqkrtsgmmqpklaekiakqtraefpegiaSYGTDALRFTFCSLASTGRDIKFD----MG 630
Cdd:PRK12267 303 SKGNVVDPEELVD-------------------------------------RYGLDALRYYLLREVPFGSDGDFSpealVE 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 631 RVegfrNF--CNKIWNAANFVIENTDGQDTGVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFI--- 705
Cdd:PRK12267 346 RI----NSdlANDLGNLLNRTVAMINKYFDGEIPAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLIsra 421
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 706 ---WDEYCAWylELVKpvlwDENapierQRGTRRTLIRVLETALR----LAHPFMPFITEEIWQRIkGQAGKEGPTLMLQ 778
Cdd:PRK12267 422 nkyIDETAPW--VLAK----DEG-----KKERLATVMYHLAESLRkvavLLSPFMPETSKKIFEQL-GLEEELTSWESLL 489
|
330 340 350
....*....|....*....|....*....|....*.
gi 9950009 779 PWPVADEG-----------RIDAAAEgdIEWVKALM 803
Cdd:PRK12267 490 EWGGLPAGtkvakgeplfpRIDVEEE--IAYIKEQM 523
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
216-346 |
6.52e-11 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 62.18 E-value: 6.52e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 216 VATTRPETLLGDAAVAVHPE----------DERYAKLI-----------------------GQFAELPIVGRHIPI-IAD 261
Cdd:pfam13603 25 VFTTRPDTLMGVTFVALAPEhplveklaekNPEVAAFIeeckntseiertsetkekegvftGLYAIHPITGEKIPIwIAN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 262 eYVDREFGTGCVKITPAHDFNDYEVGKRHDLPLINIF---DKNAAVLAQAQVFHLDGS-VNPNLdpslpqsYAGMDRFAA 337
Cdd:pfam13603 105 -FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIqpeDGDLDLDIMTEAYTEEGIlVNSGE-------FDGLDSEEA 176
|
....*....
gi 9950009 338 RKAIVAEFE 346
Cdd:pfam13603 177 KEAIIKKLE 185
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
632-764 |
3.04e-09 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 55.69 E-value: 3.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 632 VEGFRNFCNKIWNaanFVIENTDGQDTGVNgePVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIwdeyca 711
Cdd:cd07958 6 VEGAYRFLNRVWR---LVTELAEALAAPAA--AAELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMELV------ 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 9950009 712 wylelvkpvlwdeNA---PIERQRGTRRTLIRVLETALRLAHPFMPFITEEIWQRI 764
Cdd:cd07958 75 -------------NAlykYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
375-570 |
6.64e-09 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 58.41 E-value: 6.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 375 LTDQWYV-----STKPLAEDAIAavedgRIQFVPKQYENMyfswMRDIQDwcISRQLWWGHRIPaWydeagnvyvgrdev 449
Cdd:cd00812 128 LLDQWFLkysetEWKEKLLKDLE-----KLDGWPEEVRAM----QENWIG--CSRQRYWGTPIP-W-------------- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 450 evrtkhklgneaelrqdEDVLDTWFSSGLWTF-------STLGWPQQTEFLKT----FHPTDVLVTGFDIIffwvarmim 518
Cdd:cd00812 182 -----------------TDTMESLSDSTWYYArytdahnLEQPYEGDLEFDREefeyWYPVDIYIGGKEHA--------- 235
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9950009 519 lTMHLV---------KNPDGTPQIPFKTVYVHGLVRdGQGQKMSKSKGNVLDPLDIVD--GID 570
Cdd:cd00812 236 -PNHLLysrfnhkalFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAIKkyGAD 296
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
403-574 |
4.88e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 56.00 E-value: 4.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 403 PKQYENMYFSWMRD-IQDWCISRQLW-WGHRIPAwyDEAGNVYVgrdevevrtkhklgneaelrqdedvldtWF------ 474
Cdd:cd00814 164 PENARNEVLSWLKEgLKDLSITRDLFdWGIPVPL--DPGKVIYV----------------------------WFdaligy 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 475 --SSGLWTfstlGWPQQTEFLKTFHPTDVLVTGFDIIFF----WVARMIMLTMHLVKNpdgtpqipfktVYVHGLVRDGq 548
Cdd:cd00814 214 isATGYYN----EEWGNSWWWKDGWPELVHFIGKDIIRFhaiyWPAMLLGAGLPLPTR-----------IVAHGYLTVE- 277
|
170 180
....*....|....*....|....*.
gi 9950009 549 GQKMSKSKGNVLDPLDIVDGIDLDTL 574
Cdd:cd00814 278 GKKMSKSRGNVVDPDDLLERYGADAL 303
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
403-574 |
1.50e-07 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 54.60 E-value: 1.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 403 PKQYENMYFSWMRD-IQDWCISRQLWWGHRIPAwyDEAGNVYVGRDEVevrtkhkLG---NEAELRQDEDVLDTWfssgl 478
Cdd:pfam09334 207 PENVKNMVLEWLKEgLKDRAISRDLDWGIPVPG--AEGKVFYVWLDAP-------IGyisATKELSGNEEKWKEW----- 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 479 wtfstlgWPQQTEfLKTFHptdvlVTGFDIIFF----WVArMIMltmhlvknpdGTPQIPFKTVYVHGLVRDgQGQKMSK 554
Cdd:pfam09334 273 -------WPNDPD-TELVH-----FIGKDIIYFhtifWPA-MLL----------GAGYRLPTTVFAHGYLTY-EGGKMSK 327
|
170 180
....*....|....*....|
gi 9950009 555 SKGNVLDPLDIVDGIDLDTL 574
Cdd:pfam09334 328 SRGNVVWPSEALDRFPPDAL 347
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
33-166 |
5.94e-06 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 49.60 E-value: 5.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 33 YTIMIPPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVVErqlgAQGVSRHDLGRekflekvw 112
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAE----KEGITPEELVD-------- 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 9950009 113 ewkeqsggNITRQIRRLGSSVDWSRERF--TMDDGLSEAVKEAFVRLHEDGLIYRG 166
Cdd:pfam09334 69 --------RYHEIHREDFKKFNISFDDYgrTTSERHHELVQEFFLKLYENGYIYEK 116
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
40-167 |
1.60e-05 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 47.91 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 40 PNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTLWQPGTDHAGIATQMVVErqlgAQGVSRHDLGRE--KFLEKVWEWkeq 117
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAE----EEGVTPQELCDKyhEIFKDLFKW--- 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 9950009 118 sggnitrqirrLGSSVDwsreRF--TMDDGLSEAVKEAFVRLHEDGLIYRGK 167
Cdd:cd00814 82 -----------LNISFD----YFirTTSPRHKEIVQEFFKKLYENGYIYEGE 118
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
637-764 |
1.13e-04 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 42.86 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 637 NFCNKIwnaANFVIENTDGqdtgVNGEPVELSSVDRWIISQLQRTEQEVTRQLDAFRFDLAAQALYEFIWD--EYcawyl 714
Cdd:cd07957 11 NLVNRT---LNMASKYFGG----VVPEFGGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELARAanKY----- 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 715 elvkpvlWDENAP------IERQRgtRRTLIRVLETALRLA----HPFMPFITEEIWQRI 764
Cdd:cd07957 79 -------IDETAPwklakeEDPER--LATVLYVLLELLRILaillSPFMPETAEKILDQL 129
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
384-574 |
3.24e-04 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 44.32 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 384 KPLaEDAIAAvedgRIQFVPKQYE-NMYFSWMRD-IQDWCISRQLW-WGhrIPAWYDEAGNVYVGRDEVevrtkhkLGNE 460
Cdd:PLN02224 235 KPL-EDILAQ----NPRFVQPSYRlNEVQSWIKSgLRDFSISRALVdWG--IPVPDDDKQTIYVWFDAL-------LGYI 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 461 AELRQDEDvldtwfSSGLWTFSTLGWPQQTEFLktfhptdvlvtGFDIIFF----WVARMIMLTMHLVKnpdgtpqipfk 536
Cdd:PLN02224 301 SALTEDNK------QQNLETAVSFGWPASLHLI-----------GKDILRFhavyWPAMLMSAGLELPK----------- 352
|
170 180 190
....*....|....*....|....*....|....*....
gi 9950009 537 TVYVHG-LVRDGQgqKMSKSKGNVLDPLDIVDGIDLDTL 574
Cdd:PLN02224 353 MVFGHGfLTKDGM--KMGKSLGNTLEPFELVQKFGPDAV 389
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
542-632 |
3.75e-04 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 43.99 E-value: 3.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 542 GLVRDGQGQKMSKSKGNVldpldivdgIDLDTLLQKRTSGMMQPKLAEKIAKQTraefpegiasyGTDALRFTFCSLAST 621
Cdd:PRK01611 313 GLVRGGEGVKMSTRAGNV---------VTLDDLLDEAVGRARELIEEKEIAEAV-----------GIDAVRYFDLSRSRD 372
|
90
....*....|.
gi 9950009 622 gRDIKFDMGRV 632
Cdd:PRK01611 373 -KDLDFDLDLA 382
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
541-748 |
2.78e-03 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 41.29 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 541 HGLVRDGQGQKMSKSKGNVldpldivdgIDLDTLLQKRTsgmmqpKLAEKIAKQTRAEFPEGIASY-GTDALRFTFCSLA 619
Cdd:COG0018 369 FGMVNLRDGEKMSTRAGTV---------VTLDDLLDEAV------ERAREIIEEKSEEEKEEIAEQvGIDAVRYFDLSRS 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 620 STgRDIKFDMGRV---EGF----------RnfCNKIWNAANFVIENTDGQDTGVNGEPVELSSVDRwiISQLQRTEQEVT 686
Cdd:COG0018 434 RD-KDLDFDLDLAlsfEGNtnpyvqyahaR--ICSILRKAGEELDGLAEADLSLLTEEEELALIKK--LAQFPEVVEEAA 508
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9950009 687 RQLDAFR-----FDLAAqalyefiwdEYCAWYLELvkPVLWDENAPIerqRGTRRTLI----RVLETALRL 748
Cdd:COG0018 509 EDLEPHRianylYELAK---------AFHSFYNAC--RILKAEDEEL---RAARLALVaataQVLKNGLGL 565
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
40-165 |
6.31e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 40.14 E-value: 6.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 40 PNVTGSLHMGHGFNNAIMDALIRYRRMQGRNtlwqpgtdhagiatqmvVERQ-----LGAQ-GVsrhdLGREkfLEKVWE 113
Cdd:PRK01611 120 ANPTGPLHVGHLRSAVIGDALARILEFAGYD-----------------VTREyyvndAGTQiGM----LIAS--LELLWR 176
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 9950009 114 W-KEQSGGNITRQIRRLGSSVD-WSRERFTMDDGlseAVKEAFVRLHEDGLIYR 165
Cdd:PRK01611 177 KaVDISLDEIKEDLDRLGVHFDvWFSESELYYNG---KVDEVVEDLKEKGLLYV 227
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
19-165 |
7.01e-03 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 40.13 E-value: 7.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 19 ESNDYFAPSGEGQPYTIMI--PPPNVTGSLHMGHGFNNAIMDALIRYRRMQGRNTL-------WqpGT--DHAGIATQMV 87
Cdd:COG0018 102 ADGEDYGRSDAGKGKKVVVeyVSANPTKPLHVGHLRGAVIGDALARILEAAGYDVTrenyindA--GTqiGKLALSLERY 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9950009 88 VERQLGAQGVSRHDLGR-------------------EKFLEK----------VWEW-KEQSGGNITRQIRRLGSSVD-WS 136
Cdd:COG0018 180 GEEEIEPESKPDGYLGDlyvkfhkeyeedpelediaRELLAKlepgdeealeLWKKaVDWSLEEIKEDLKRLGVEFDvWF 259
|
170 180
....*....|....*....|....*....
gi 9950009 137 RERFTMDDGlseAVKEAFVRLHEDGLIYR 165
Cdd:COG0018 260 SESSLYDSG---AVEEVVEELKEKGLLYE 285
|
|
| |
