|
Name |
Accession |
Description |
Interval |
E-value |
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
4-460 |
0e+00 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 529.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 4 RRSLTLYAALLFAAVAALVVSAVGFYLYRSVEEAMLRRSDVMVAGRVEHFRNLLRDNLTLAE-LKARPRLFENMLGNEQD 82
Cdd:TIGR01386 1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPADLDEdIKRLQEKIDDLLVGHSD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 83 ILLLGQPGEAPIVAVNPRHERLPSLRVVAAGQALNPSVVhAALTHDGIPMRVLAAEVLVGGREPLQITAAHLLLGETRML 162
Cdd:TIGR01386 81 LALSILNPDGRLLFERAQGAALVPAVAANDALLELDQAD-AKMTHYRSILRSVAALPGGKGRKPVQITVALDINAHTHLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 163 AQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLDTRLDVAAAPAELQQVAQSFNAMLERLDDGYQ 242
Cdd:TIGR01386 160 DALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDAFQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 243 RLQQFSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGE 322
Cdd:TIGR01386 240 RLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 323 ELRRQAEYFEGLAEERGLSLDVQVSGQLRADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPA 402
Cdd:TIGR01386 320 ELAKVAEYFEPLAEERGVRIRVEGEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIPP 399
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 9951160 403 EPLSRLFDRFYRGDAARSDAQS-SGLGLAIVQAIMRLHGGRAEASAPaPGRIRFDLAFP 460
Cdd:TIGR01386 400 EHLSRLFDRFYRVDPARSNSGEgTGLGLAIVRSIMEAHGGRASAESP-DGKTRFILRFP 457
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
122-460 |
1.96e-70 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 231.20 E-value: 1.96e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 122 HAALTHDGIPM-----RVLAAEV--LVGGREPLQITAAHLLLGETRMLAQYRDRVIAAVLLAFLGTALLGWLVLRHGLRP 194
Cdd:PRK09835 133 PMMPGHGHGHMehsnwRMIALPVgpLVDGKPIYTLLIALSIDFHLHYINDLKNKLIMTASVISLLIVFIVLLAVHKGHAP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 195 LRTLAAKAAEIHPTSLDTRLDVAAAPAELQQVAQSFNAMLERLDDGYQRLQQFSADLAHEIRTPIGSLMGHGQVALRQPR 274
Cdd:PRK09835 213 IRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSR 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 275 SNEEYQALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGEELRRQAEYFEGLAEERGLSLDVQVSG-QLRAD 353
Cdd:PRK09835 293 SQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPcQVAGD 372
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 354 PQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARS-DAQSSGLGLAIV 432
Cdd:PRK09835 373 PLMLRRAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQrKGEGSGIGLAIV 452
|
330 340
....*....|....*....|....*...
gi 9951160 433 QAIMRLHGGRAEASAPAPGrIRFDLAFP 460
Cdd:PRK09835 453 KSIVVAHKGTVAVTSDARG-TRFVISLP 479
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
231-463 |
8.11e-52 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 175.10 E-value: 8.11e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 231 NAMLERLDdgyQRLQQFSADLAHEIRTPIGSLMGHGQVALRQPR-SNEEYQALIASNQEELERIARMVESILFLARADDV 309
Cdd:COG2205 6 LEELEELE---RLKSEFLANVSHELRTPLTSILGAAELLLDEEDlSPEERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 310 RAAVERSRLDLGEELRRQAEYFEGLAEERGLSLDVQVSGQL---RADPQLFRRALSNLLANAIRYASADSLIEVRGLRRS 386
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELplvYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9951160 387 GEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSdAQSSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFPAQD 463
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGDNSRG-EGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
135-462 |
9.34e-51 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 175.10 E-value: 9.34e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 135 LAAEVLVGGREPLQITAAHLLLGETRMLAQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLDTRL 214
Cdd:COG0642 1 LLLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 215 DVAAAPAELQQVAQSFNAMLERLDDGYQRLQQFSADLAHEIRTPIGSLMGHGQVALRQPrsNEEYQALIASNQEELERIA 294
Cdd:COG0642 81 LLLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEEL--DEEQREYLETILRSADRLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 295 RMVESILFLARADDVRAAVERSRLDLGEELRRQAEYFEGLAEERGLSLDVQVSGQL---RADPQLFRRALSNLLANAIRY 371
Cdd:COG0642 159 RLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLptvRGDPDRLRQVLLNLLSNAIKY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 372 ASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSdAQSSGLGLAIVQAIMRLHGGRAEASAPAPG 451
Cdd:COG0642 239 TPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRR-GGGTGLGLAIVKRIVELHGGTIEVESEPGK 317
|
330
....*....|.
gi 9951160 452 RIRFDLAFPAQ 462
Cdd:COG0642 318 GTTFTVTLPLA 328
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
134-445 |
5.96e-50 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 174.74 E-value: 5.96e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 134 VLAAEVLVGGREPLQITAAHLLLGETRMLAQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLDTR 213
Cdd:COG5002 59 LLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 214 LDVAAAPAELQQVAQSFNAmLERLDdgyQRLQQFSADLAHEIRTPIGSLMGHGQVALRQP-RSNEEYQALIASNQEELER 292
Cdd:COG5002 139 SALLLGLLLLAAVERDITE-LERLE---QMRREFVANVSHELRTPLTSIRGYLELLLDGAaDDPEERREYLEIILEEAER 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 293 IARMVESILFLARADDVRAAVERSRLDLGEELRRQAEYFEGLAEERGLSLDVQVSGQ---LRADPQLFRRALSNLLANAI 369
Cdd:COG5002 215 LSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpllVLGDPDRLEQVLTNLLDNAI 294
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9951160 370 RYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDAQS-SGLGLAIVQAIMRLHGGRAEA 445
Cdd:COG5002 295 KYTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGgTGLGLAIVKHIVEAHGGRIWV 371
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
166-461 |
5.75e-35 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 135.74 E-value: 5.75e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 166 RDRVIAAVLLAFLGTALLGWLV---LRHGLRPLRTLAAKAAEIHPTSLDTRldvaaAPAELQQVAQSFNAMLERLDdGYQ 242
Cdd:PRK11100 181 ERRILWAGALLLGIALLIGAGVvwwLNRSIRRLTRYADAVTEGKPVPLPKL-----GSSELRELAQALESMRVKLE-GKA 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 243 RLQQFSADLAHEIRTPIGSLMGHGQVaLRQPRSNEEYQALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGE 322
Cdd:PRK11100 255 YVEQYVQTLTHELKSPLAAIRGAAEL-LQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAA 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 323 ELRRQAEYFEGLAEERGLSLDVQVSG-QLRADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLP 401
Cdd:PRK11100 334 LLEELVEAREAQAAAKGITLRLRPDDaRVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGIP 413
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9951160 402 AEPLSRLFDRFY---RGDAARSdaqSSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFPA 461
Cdd:PRK11100 414 DYALPRIFERFYslpRPANGRK---STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
169-460 |
9.03e-27 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 112.42 E-value: 9.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 169 VIAAVLLAFLGTallgWLVLRHGLRPLRTLAAKAAEIHPTSLDTRLDVAAAPaELQQVAQSFNAMLERLDDGYQRLQQFS 248
Cdd:PRK10549 170 VALSTLLAALAT----FLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRD-ELGRLAQDFNQLASTLEKNEQMRRDFM 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 249 ADLAHEIRTPIGSLMGHG---QVALRQPRSneeyqALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGEELR 325
Cdd:PRK10549 245 ADISHELRTPLAVLRGELeaiQDGVRKFTP-----ESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLE 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 326 RQAEYFEGLAEERGLSLDVQVSGQLR--ADP----QLFrralSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDR 399
Cdd:PRK10549 320 VAGGAFRERFASRGLTLQLSLPDSATvfGDPdrlmQLF----NNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPG 395
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9951160 400 LPAEPLSRLFDRFYRGDAARSDAQ-SSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFP 460
Cdd:PRK10549 396 VSDEQLQKLFERFYRTEGSRNRASgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
3-457 |
9.88e-24 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 103.71 E-value: 9.88e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 3 ARRSLTLYAALLFAAVAALVVSAVGFYLYRSVEEAMLRRSDVMVAGRVEHFRNLLRDNLTLAELKARPRLFENMLGNEQD 82
Cdd:COG4251 44 LLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLL 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 83 ILLLGQPGEAPIVAVNPRHERLPSLRVVAAGQALNPSVVHAALTHDGIPMRVLAAEVLVGGREPLQITAAHLLLGETRML 162
Cdd:COG4251 124 ALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 163 AQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLDTRLDVAAAPAELQQVAQSFNAMLERLddgYQ 242
Cdd:COG4251 204 RLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERS---NE 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 243 RLQQFSADLAHEIRTPIGSLMGHGQVALRQPRS--NEEYQALIASNQEELERIARMVESILFLARADdvRAAVERSRLDL 320
Cdd:COG4251 281 ELEQFAYVASHDLREPLRKISGFSQLLEEDYGDklDEEGREYLERIRDAAERMQALIDDLLAYSRVG--RQELEFEPVDL 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 321 GEELRRQAEYFEGLAEERGLSLDVQVSGQLRADPQLFRRALSNLLANAIRYASADS--LIEVRGLRRSGEFLLSVENACD 398
Cdd:COG4251 359 NELLEEVLEDLEPRIEERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEppRIEIGAEREGGEWVFSVRDNGI 438
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9951160 399 RLPAEPLSRLFDRFYRGDaARSDAQSSGLGLAIVQAIMRLHGGRAEA-SAPAPG-RIRFDL 457
Cdd:COG4251 439 GIDPEYAEKIFEIFQRLH-SRDEYEGTGIGLAIVKKIVERHGGRIWVeSEPGEGaTFYFTL 498
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
357-457 |
1.92e-23 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 94.21 E-value: 1.92e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 357 FRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSdAQSSGLGLAIVQAIM 436
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSRE-GGGTGLGLAIVRRIV 79
|
90 100
....*....|....*....|...
gi 9951160 437 RLHGGRAEA-SAPAPG-RIRFDL 457
Cdd:cd00075 80 EAHGGRITVeSEPGGGtTFTVTL 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
352-457 |
4.32e-23 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 93.48 E-value: 4.32e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 352 ADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVEnacDR---LPAEPLSRLFDRFYRGDAARSDAQSSGLG 428
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVE---DNgpgIPPEDLEKIFEPFFRTDKRSRKIGGTGLG 77
|
90 100 110
....*....|....*....|....*....|.
gi 9951160 429 LAIVQAIMRLHGGRAEA-SAPAPG-RIRFDL 457
Cdd:smart00387 78 LSIVKKLVELHGGEISVeSEPGGGtTFTITL 108
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
181-451 |
9.25e-23 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 100.49 E-value: 9.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 181 ALLGWLVLRhGLRPLRTLAAKAAEIHPTSlDTRLDVAAAPAELQQVAQSFNAMLERLDDGYQRLQQFSADLAHEIRTPIG 260
Cdd:PRK10337 176 IILMVLLGR-ELAPLKKLALALRMRDPDS-ETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLA 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 261 SLMGHGQVA-LRQPRSNEEYQALiASNQEELERIARMVESILFLARADDVRAAVERSRLDLGEELRRQAEYFEGLAEERG 339
Cdd:PRK10337 254 ALKVQTEVAqLSDDDPQARKKAL-LQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIYHTAQQAG 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 340 --LSLDVQVSGQLR-ADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSgeflLSVENACDRLPAEPLSRLFDRFYRGD 416
Cdd:PRK10337 333 idVRLTLNAHPVIRtGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN----FTVRDNGPGVTPEALARIGERFYRPP 408
|
250 260 270
....*....|....*....|....*....|....*.
gi 9951160 417 AarSDAQSSGLGLAIVQAIMRLHGGRAE-ASAPAPG 451
Cdd:PRK10337 409 G--QEATGSGLGLSIVRRIAKLHGMNVSfGNAPEGG 442
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
174-442 |
1.43e-22 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 98.50 E-value: 1.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 174 LLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLdTRLDVAAAPAELQQVAQSFNAMLERLDDGYQRLQQFSADLAH 253
Cdd:PRK10755 68 LVMVSLTLLICFQAVRWITRPLAELQKELEARTADNL-TPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAH 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 254 EIRTPIGSLMGHgqVALRQPRSNEEYQALIAsnqeELERIARMVESILFLARADDVRAAVERSRLDLGEE--LRRQAEyF 331
Cdd:PRK10755 147 ELRTPLAGIRLH--LELLEKQHHIDVAPLIA----RLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDviLPSQDE-L 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 332 EGLAEERGLSLDVQVS---GQLRADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVE---NACDRLPAEPL 405
Cdd:PRK10755 220 SEMLEQRQQTLLLPESaadITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEdegPGIDESKCGEL 299
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 9951160 406 SRLFDRF---YRGdaarsdaqsSGLGLAIVQAIMRLHGGR 442
Cdd:PRK10755 300 SKAFVRMdsrYGG---------IGLGLSIVSRITQLHHGQ 330
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
242-463 |
1.89e-22 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 99.27 E-value: 1.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 242 QRL---QQFSADLAHEIR---TPIGSLMGHGQVALRQ--PRSNEEYQALIASNQEELERIARMVESILFLARaddvRAAV 313
Cdd:COG5000 196 ERLaawGELARRIAHEIKnplTPIQLSAERLRRKLADklEEDREDLERALDTIIRQVDRLKRIVDEFLDFAR----LPEP 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 314 ERSRLDLGEELRRQAEYFEGLAEERGLSLDVQVSGQL---RADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFL 390
Cdd:COG5000 272 QLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLpevLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVR 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9951160 391 LSVENACDRLPAEPLSRLFDRFY----RGdaarsdaqsSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFPAQD 463
Cdd:COG5000 352 IEVSDNGPGIPEEVLERIFEPFFttkpKG---------TGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
168-460 |
2.51e-22 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 98.91 E-value: 2.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 168 RVIAAVLLAFLGT--ALLGWLVLRHGLRPLRTLAAKAAEIHPTSLDTRLDVAAAPAeLQQVAQSFNAMLERLDDGYQRLQ 245
Cdd:PRK10604 135 RLLDIALLALIGLslAFPVFLWMRPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSS-LERLGVAFNQMADNINALIASKK 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 246 QFSADLAHEIRTPIGSLmgHGQVALRQPRSNEEYQALiasnQEELERIARMVESILFLARADDVRAAVERSRLDLGEELR 325
Cdd:PRK10604 214 QLIDGIAHELRTPLVRL--RYRLEMSDNLSAAESQAL----NRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLS 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 326 RQAEYFEGLAEERGLSLDVQVSGQ-LRADPQLFRRALSNLLANAIRYAsaDSLIEVRGLRRSGEFLLSVENACDRLPAEP 404
Cdd:PRK10604 288 THLADIQAVTPEKTVRLDTPHQGDyGALDMRLMERVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEE 365
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 9951160 405 LSRLFDRFYRGDAARSDAQSS-GLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFP 460
Cdd:PRK10604 366 RERVFEPFVRLDPSRDRATGGcGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWP 422
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
132-462 |
4.05e-21 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 94.48 E-value: 4.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 132 MRVLAAEVLVGGREPLQITAAHLLLGETRMLAQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLD 211
Cdd:COG4191 21 ALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 212 TRLDVAAAPAELQQVAQSFNAMLERLDDGYQRLQQ---------FSADLAHEIRTPIGSLMGHGQVA---LRQPRSNEEY 279
Cdd:COG4191 101 LDAEENAELEELERDITELERAEEELRELQEQLVQseklaalgeLAAGIAHEINNPLAAILGNAELLrrrLEDEPDPEEL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 280 QALIASNQEELERIARMVESILFLARADDVraavERSRLDLGEELRRQAEYFEGLAEERGLSLDVQVSGQL---RADPQL 356
Cdd:COG4191 181 REALERILEGAERAAEIVRSLRAFSRRDEE----EREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLppvLGDPGQ 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 357 FRRALSNLLANAIrYASADSL---IEVRGLRRSGEFLLSVE-NACdRLPAEPLSRLFDRFYrgdAARSDAQSSGLGLAIV 432
Cdd:COG4191 257 LEQVLLNLLINAI-DAMEEGEggrITISTRREGDYVVISVRdNGP-GIPPEVLERIFEPFF---TTKPVGKGTGLGLSIS 331
|
330 340 350
....*....|....*....|....*....|
gi 9951160 433 QAIMRLHGGRAEASAPAPGRIRFDLAFPAQ 462
Cdd:COG4191 332 YGIVEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
170-461 |
7.84e-21 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 93.52 E-value: 7.84e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 170 IAAVLL-AFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLDTRL-DVAAAPAELQQVAQSFNAMLERLDDGYQRLQQF 247
Cdd:NF012226 62 LFTVILcGSVISLIIGMKLAQRFIVPINFLADAAKKISQGDLSARAeDSQIHSAEISELMHNFNDMAQKLESSVKNAQVW 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 248 SADLAHEIRTPIGSLMGHGQVALR---QPRsneeyQALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGEEL 324
Cdd:NF012226 142 NAAIAHELRTPITILQGRLQGILDgvfEPD-----PALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSI 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 325 RRQAEYFEGLAEERGLSLDVQVS-GQLRADPQLFRRALSNLLANAIRYASAdSLIEVRGLRRSGEFLLSVENACDRLPAE 403
Cdd:NF012226 217 EKVLKMFEDRLEQAQLTIVLNLTaTPVFCDRRRIEQVLIALIDNAIRYANA-GKLKISSSVIQDDWILQIEDEGPGIAEE 295
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 9951160 404 PLSRLFDRFYRGDAARSDAQ-SSGLGLAIVQAIMRLHGGRAEASAPAPGRIrFDLAFPA 461
Cdd:NF012226 296 YQQDLFNPFFRLEQSRNKEFgGTGLGLAVVHAIVIAHKGSIEYSNSQGNSV-FTIKLPA 353
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
173-460 |
8.47e-20 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 91.53 E-value: 8.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 173 VLLAFLGTALLGWLVLRHGlRPLRTLAAKAAEIHPTSLDTRLDVAAAPAELQQVAQSFNAM---LERLDDGYQRLQqfsA 249
Cdd:PRK09470 173 LVTMLVSTPLLLWLAWSLA-KPARKLKNAADEVAQGNLRQHPELETGPQEFRQAGASFNQMvtaLERMMTSQQRLL---S 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 250 DLAHEIRTPIGSLmghgQVAL-----RQPRSNEeyqalIASNQEELERIARMVESILFLARaDDVRAAVERSRLD---LG 321
Cdd:PRK09470 249 DISHELRTPLTRL----QLATallrrRQGESKE-----LERIETEAQRLDSMINDLLVLSR-NQQKNHLERETFKansLW 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 322 EELRRQAEyFEglAEERGLSLDVQ-------VSGqlraDPQLFRRALSNLLANAIRYasADSLIEVRGLRRSGEFLLSVE 394
Cdd:PRK09470 319 SEVLEDAK-FE--AEQMGKSLTVSappgpwpING----NPNALASALENIVRNALRY--SHTKIEVAFSVDKDGLTITVD 389
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9951160 395 NACDRLPAEPLSRLFDRFYRGDAARsDAQS--SGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFP 460
Cdd:PRK09470 390 DDGPGVPEEEREQIFRPFYRVDEAR-DRESggTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLP 456
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
247-462 |
1.25e-19 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 90.84 E-value: 1.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 247 FSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALIASNQEELERIARMVESILFLARaddVRAAverSRLDLGEE--- 323
Cdd:PRK11006 207 FFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLSK---IEAA---PTIDLNEKvdv 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 324 ------LRRQAEyfeGLAEER-GLSLDVQVSGQLRADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENA 396
Cdd:PRK11006 281 pmmlrvLEREAQ---TLSQGKhTITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDN 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9951160 397 CDRLPAEPLSRLFDRFYRGDAARS-DAQSSGLGLAIVQAIMRLHGGRAE-ASAPAPGRiRFDLAFPAQ 462
Cdd:PRK11006 358 GPGIAPEHIPRLTERFYRVDKARSrQTGGSGLGLAIVKHALSHHDSRLEiESEVGKGT-RFSFVLPER 424
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
352-462 |
1.63e-19 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 83.57 E-value: 1.63e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 352 ADPQLFRRALSNLLANAIRYASADSLIEVRgLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDaaRSDAQSSGLGLAI 431
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVT-LSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTAD--KRGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|.
gi 9951160 432 VQAIMRLHGGRAEASAPAPGRIRFDLAFPAQ 462
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPLA 108
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-460 |
1.71e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 80.58 E-value: 1.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 353 DPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDAQ-SSGLGLAI 431
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASgGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 9951160 432 VQAIMRLHGGRAEASAPAPGRIRFDLAFP 460
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-446 |
3.70e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 79.35 E-value: 3.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 358 RRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARsDAQSSGLGLAIVQAIMR 437
Cdd:cd16923 2 QRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSR-NTEGAGLGLSIAKAIIE 80
|
....*....
gi 9951160 438 LHGGRAEAS 446
Cdd:cd16923 81 LHGGSASAE 89
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
244-442 |
2.26e-16 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 80.28 E-value: 2.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 244 LQQFSADLAHEIRTPIGSLMGHGQVALRQPrSNEEYQALIASNQEELERIARMVESILFLARaddvRAAVERSRLDLGEE 323
Cdd:COG3852 135 VGELAAGLAHEIRNPLTGIRGAAQLLEREL-PDDELREYTQLIIEEADRLNNLVDRLLSFSR----PRPPEREPVNLHEV 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 324 LRR-----QAEYFEGLAEERGLSLDVqvsGQLRADPQLFRRALSNLLANAIRYASADSLIEVR----------GLRRSGE 388
Cdd:COG3852 210 LERvlellRAEAPKNIRIVRDYDPSL---PEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRtrverqvtlgGLRPRLY 286
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 9951160 389 FLLSVEnacDR---LPAEPLSRLFDRFYRGDAarsdaQSSGLGLAIVQAIMRLHGGR 442
Cdd:COG3852 287 VRIEVI---DNgpgIPEEILDRIFEPFFTTKE-----KGTGLGLAIVQKIVEQHGGT 335
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
343-452 |
6.01e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 73.59 E-value: 6.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 343 DVQVSGqlraDPQLFRRALSNLLANAIRYASADSLIEVRgLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAarSDA 422
Cdd:cd16940 4 DIQVQG----DALLLFLLLRNLVDNAVRYSPQGSRVEIK-LSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG--QNY 76
|
90 100 110
....*....|....*....|....*....|.
gi 9951160 423 QSSGLGLAIVQAIMRLHGGRAEAS-APAPGR 452
Cdd:cd16940 77 GGSGLGLSIVKRIVELHGGQIFLGnAQGGGL 107
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
244-445 |
9.58e-16 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 79.63 E-value: 9.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 244 LQQFSADLAHEIRTPIGSLMGHGQVALRQPRSNE--EYQALIAsnqEELERIARMVESILFLARAddvrAAVERSRLDLG 321
Cdd:PRK11360 390 LGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPsqEYLSVVL---REVDRLNKVIDQLLEFSRP----RESQWQPVSLN 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 322 EELRRQAeyfeGLAEERGLSLDVQVSGQLR-------ADPQLFRRALSNLLANAIRYASADSLIEVR-GLRRSGEFLLSV 393
Cdd:PRK11360 463 ALVEEVL----QLFQTAGVQARVDFETELDnelppiwADPELLKQVLLNILINAVQAISARGKIRIRtWQYSDGQVAVSI 538
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 9951160 394 ENACDRLPAEPLSRLFDRFYRgdaarSDAQSSGLGLAIVQAIMRLHGGRAEA 445
Cdd:PRK11360 539 EDNGCGIDPELLKKIFDPFFT-----TKAKGTGLGLALSQRIINAHGGDIEV 585
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-444 |
2.76e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 71.72 E-value: 2.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 353 DPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDAQSSGLGLAIV 432
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKSTGLGLAFV 80
|
90
....*....|..
gi 9951160 433 QAIMRLHGGRAE 444
Cdd:cd16945 81 QEVAQLHGGRIT 92
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-461 |
2.46e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 68.89 E-value: 2.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 357 FRRALSNLLANAIRYAsaDSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARS-DAQSSGLGLAIVQAI 435
Cdd:cd16949 1 LARALENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDrESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 9951160 436 MRLHGGRAEASAPAPGRIRFDLAFPA 461
Cdd:cd16949 79 IEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-460 |
2.98e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 65.69 E-value: 2.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 358 RRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDAQS-SGLGLAIVQAIM 436
Cdd:cd16952 2 RSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgTGLGLAIVKHVM 81
|
90 100
....*....|....*....|....*
gi 9951160 437 RLHGGRAE-ASAPAPGRiRFDLAFP 460
Cdd:cd16952 82 SRHDARLLiASELGKGS-RFTCLFP 105
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-451 |
1.26e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 63.62 E-value: 1.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 358 RRALSNLLANAIRYASADslIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARsDAQSSGLGLAIVQAIMR 437
Cdd:cd16950 2 KRVLSNLVDNALRYGGGW--VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNAR-GTSGTGLGLAIVQRISD 78
|
90
....*....|....
gi 9951160 438 LHGGRAEASAPAPG 451
Cdd:cd16950 79 AHGGSLTLANRAGG 92
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
242-305 |
1.49e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 62.23 E-value: 1.49e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9951160 242 QRLQQFSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALIASNQEELERIARMVESILFLAR 305
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
235-442 |
2.07e-12 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 68.44 E-value: 2.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 235 ERLDDGYQRLQQFSADLAHEIRTPI--GSLMGHGQVALRQPRSNEEYQALIASNQE----ELERIARMVESILFLARADD 308
Cdd:PRK09303 142 ETLLEQLKFKDRVLAMLAHDLRTPLtaASLALETLELGQIDEDTELKPALIEQLQDqarrQLEEIERLITDLLEVGRTRW 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 309 VRAAVERSRLDLGEELRRQAEYFEGLAEERGLSLDVQVSGQL---RADPQLFRRALSNLLANAIRYASADSLIEVRGLRR 385
Cdd:PRK09303 222 EALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLpsvYADQERIRQVLLNLLDNAIKYTPEGGTITLSMLHR 301
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 9951160 386 SGEFL-LSVenaCDR---LPAEPLSRLFDRFYRGDaaRSDAQSS-GLGLAIVQAIMRLHGGR 442
Cdd:PRK09303 302 TTQKVqVSI---CDTgpgIPEEEQERIFEDRVRLP--RDEGTEGyGIGLSVCRRIVRVHYGQ 358
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-461 |
3.52e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 62.45 E-value: 3.52e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 359 RALSNLLANAIRYAsaDSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDAQSS-GLGLAIVQAIMR 437
Cdd:cd16939 3 RALDNLLRNALRYA--HRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGfGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....
gi 9951160 438 LHGGRAEASAPAPGRIRFDLAFPA 461
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWPR 104
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
353-460 |
6.02e-12 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 62.12 E-value: 6.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 353 DPQLFRRALSNLLANAIRYASADSLIEVR-GLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDAQS-SGLGLA 430
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCIlEKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGgTGLGLS 80
|
90 100 110
....*....|....*....|....*....|.
gi 9951160 431 IVQAIMRLHGGRAEAS-APAPGRIrFDLAFP 460
Cdd:cd16925 81 IVKEFVELHGGTVTVSdAPGGGAL-FQVELP 110
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
244-460 |
6.49e-12 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 67.12 E-value: 6.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 244 LQQFSADLAHEIRTPIGSLMGHGQ-VALRQPRSNEEYQaLIASNQEELERIARMVESILFLARADDVRAAVersrLDLGE 322
Cdd:PRK10364 237 LGHLAAGVAHEIRNPLSSIKGLAKyFAERAPAGGEAHQ-LAQVMAKEADRLNRVVSELLELVKPTHLALQA----VDLND 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 323 ELRRQAEYFEGLAEERGLSLDVQVSGQL---RADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDR 399
Cdd:PRK10364 312 LINHSLQLVSQDANSREIQLRFTANDTLpeiQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKG 391
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9951160 400 LPAEPLSRLFDRFYRgdaarSDAQSSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFP 460
Cdd:PRK10364 392 IAADQLEAIFTPYFT-----TKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
353-460 |
8.23e-12 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 67.37 E-value: 8.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 353 DPQLFRRALSNLLANAIRYASADSLIEVRGlRRSGEFL-LSVENACDRLPAEPLSRLFDRFYRGDAaRSDAQSSGLGLAI 431
Cdd:PRK10490 775 DGPLFERVLINLLENAVKYAGAQAEIGIDA-HVEGERLqLDVWDNGPGIPPGQEQLIFDKFARGNK-ESAIPGVGLGLAI 852
|
90 100
....*....|....*....|....*....
gi 9951160 432 VQAIMRLHGGRAEASAPAPGRIRFDLAFP 460
Cdd:PRK10490 853 CRAIVEVHGGTIWAENRPEGGACFRVTLP 881
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
246-462 |
1.11e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 67.45 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 246 QFSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGEELR 325
Cdd:PRK09959 714 QFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQ 793
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 326 RQAEYFEGLAEERGLSLDVQVSGQ----LRADPQLFRRALSNLLANAIRYAS------ADSLIEVRGlrRSGEFLLSVEN 395
Cdd:PRK09959 794 NTCHSFGAIAASKSIALSCSSTFPdhylVKIDPQAFKQVLSNLLSNALKFTTegavkiTTSLGHIDD--NHAVIKMTIMD 871
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9951160 396 ACDRLPAEPLSRLFDRFYRGDAARSDAqSSGLGLAIVQAIMR-LHGGRAEASAPAPGrIRFDLAFPAQ 462
Cdd:PRK09959 872 SGSGLSQEEQQQLFKRYSQTSAGRQQT-GSGLGLMICKELIKnMQGDLSLESHPGIG-TTFTITIPVE 937
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
169-441 |
1.41e-11 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 66.09 E-value: 1.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 169 VIAavLLAFLGtallGWLVLRHGLRPLRTLAaKAAE-----IHPTSLDtrldvAAAPAELQQVAQSFNAMLErlddGYQR 243
Cdd:PRK09467 161 AIG--LLSVAG----GWLFIRIQNRPLVALE-HAALqvgkgEIPPPLR-----EYGASEVRSVTRAFNQMAA----GIKQ 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 244 LQQ----FSADLAHEIRTPigslmghgqvalrqprsneeyqaliasnqeeLERIaR-----MVESILFLARA-----DDV 309
Cdd:PRK09467 225 LEDdrtlLMAGVSHDLRTP-------------------------------LTRI-RlatemMSEEDGYLAESinkdiEEC 272
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 310 RAAVER--SRLDLGEELRRQAEYFEGLAEE-------RGLSLDVQVS---GQLRADPQLFRRALSNLLANAIRYASADsl 377
Cdd:PRK09467 273 NAIIEQfiDYLRTGQEMPMEMADLNALLGEviaaesgYEREIETALQpgpIEVPMNPIAIKRALANLVVNAARYGNGW-- 350
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9951160 378 IEVRgLRRSGEFL-LSVENACDRLPAEPLSRLFDRFYRGDAARSdAQSSGLGLAIVQAIMRLHGG 441
Cdd:PRK09467 351 IKVS-SGTEGKRAwFQVEDDGPGIPPEQLKHLFQPFTRGDSARG-SSGTGLGLAIVKRIVDQHNG 413
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
246-441 |
1.76e-11 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 66.73 E-value: 1.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 246 QFSADLAHEIRTPIGSLMGHGQVaLRQPRSNEEYQALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGEELR 325
Cdd:TIGR02956 466 AFLATMSHEIRTPLNGILGTLEL-LGDTGLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLSISPRPFDLNALLD 544
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 326 RQAEYFEGLAEERGLSLDVQVSGQL----RADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLP 401
Cdd:TIGR02956 545 DVHHLMVSRAQLKGIQLRLNIPEQLpnwwQGDGPRIRQVLINLVGNAIKFTDRGSVVLRVSLNDDSSLLFEVEDTGCGIA 624
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 9951160 402 AEPLSRLFDRFYRGDAARSdAQSSGLGLAIVQAIMRLHGG 441
Cdd:TIGR02956 625 EEEQATLFDAFTQADGRRR-SGGTGLGLAISQRLVEAMDG 663
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-460 |
7.06e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 58.97 E-value: 7.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 354 PQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYrgdAARSDAQSSGLGLAIVQ 433
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF---TTKPVGEGTGLGLSLSY 77
|
90 100
....*....|....*....|....*..
gi 9951160 434 AIMRLHGGRAEASAPAPGRIRFDLAFP 460
Cdd:cd16943 78 RIIQKHGGTIRVASVPGGGTRFTIILP 104
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
243-307 |
3.22e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 55.68 E-value: 3.22e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9951160 243 RLQQFSADLAHEIRTPIGSLMGHGQVaLRQPRSNEEYQALIASNQEELERIARMVESILFLARAD 307
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
243-307 |
4.72e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 55.26 E-value: 4.72e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9951160 243 RLQQFSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALiASNQEELERIARMVESILFLARAD 307
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYL-ETILREAERLLRLINDLLDLSRIE 64
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
334-463 |
5.30e-10 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 61.02 E-value: 5.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 334 LAEERGLSLDVQVSGQLRA---DPQLFRRALSNLLANAIRYASA----DSLIEVRGLRRSGEFLLSVENACDRLPAEPLS 406
Cdd:COG3290 256 RARERGIDLTIDIDSDLPDlplSDTDLVTILGNLLDNAIEAVEKlpeeERRVELSIRDDGDELVIEVEDSGPGIPEELLE 335
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 9951160 407 RLFDRFYrgdaarS--DAQSSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFPAQD 463
Cdd:COG3290 336 KIFERGF------StkLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-441 |
2.23e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 54.89 E-value: 2.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 359 RALSNLLANAIRYASADSL-IEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSD-AQSSGLGLAIVQAIM 436
Cdd:cd16953 3 QVLRNLIGNAISFSPPDTGrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAfGQHSGLGLSISRQII 82
|
....*
gi 9951160 437 RLHGG 441
Cdd:cd16953 83 EAHGG 87
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-441 |
3.21e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 54.39 E-value: 3.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 353 DPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDAQSSGLGLAIV 432
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGHYGMGLYIA 80
|
....*....
gi 9951160 433 QAIMRLHGG 441
Cdd:cd16975 81 KNLVEKHGG 89
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
159-439 |
7.64e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 57.72 E-value: 7.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 159 TRMLAQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLdTRLDVAAaPAELQQVAQSFNAMLERld 238
Cdd:COG2972 149 FRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSG-NDEIGILARSFNEMVER-- 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 239 dgYQRLQQfsadlaheirtpigslmghgQVALRQPRSNE-EYQAL---------------IAS--NQEELERIARMVESI 300
Cdd:COG2972 225 --IKELIE--------------------EVYELELEKKEaELKALqaqinphflfntlnsIRWlaELEDPEEAEEMLEAL 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 301 lflarADDVRAAVERSRLD--LGEELRRQAEYFEGL---AEERgLSLDVQVSGQLRaDPQLFRRALSNLLANAIRYA--- 372
Cdd:COG2972 283 -----SKLLRYSLSKGDELvtLEEELELIKSYLEIQklrFGDR-LEVEIEIDEELL-DLLIPKLILQPLVENAIEHGiep 355
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9951160 373 -SADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFyrgdaaRSDAQSSGLGLAIVQAIMRLH 439
Cdd:COG2972 356 kEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL------SSKGEGRGIGLRNVRERLKLY 417
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-442 |
1.02e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 52.71 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 358 RRALSNLLANAIRYASAD--SLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAaRSDAQSSGLGLAIVQAI 435
Cdd:cd16921 2 GQVLTNLLGNAIKFRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS-REEYEGTGVGLAIVRKI 80
|
....*..
gi 9951160 436 MRLHGGR 442
Cdd:cd16921 81 IERHGGR 87
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-435 |
2.93e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 51.52 E-value: 2.93e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9951160 360 ALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDAQSSGLGLAIVQAI 435
Cdd:cd16948 9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQESTGMGLYLVKKL 84
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
357-442 |
5.30e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 50.95 E-value: 5.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 357 FRRALSNLLANAIRYASadslievrglrrSGEFLLSV-----ENACDRL-----------PAEPLSRLFDRFYRGDAARS 420
Cdd:cd16922 1 LRQILLNLLGNAIKFTE------------EGEVTLRVsleeeEEDGVQLrfsvedtgigiPEEQQARLFEPFSQADSSTT 68
|
90 100
....*....|....*....|...
gi 9951160 421 -DAQSSGLGLAIVQAIMRLHGGR 442
Cdd:cd16922 69 rKYGGTGLGLAISKKLVELMGGD 91
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
172-463 |
7.23e-08 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 55.03 E-value: 7.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 172 AVLLAFLGTALLGWlVLRHGL-RPLRTLAAKAAEIHPTSLDTRLdVAAAPAELQQVAQSFNAMLERLDDGYQRLQQFSA- 249
Cdd:PRK15347 302 ALLILVLLTSVLFL-LLRRYLaKPLWRFVDIINKTGPAALEPRL-PENRLDELGSIAKAYNQLLDTLNEQYDTLENKVAe 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 250 ------------------------DLAHEIRTPIGSLMGHGQVALRQPRSNEeyqaliasnQEELERIARM-VESILFLa 304
Cdd:PRK15347 380 rtqalaeakqraeqankrksehltTISHEIRTPLNGVLGALELLQNTPLTAE---------QMDLADTARQcTLSLLAI- 449
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 305 raddVRAAVERSRLDLGE-ELrrQAEYFEGL-------------AEERGLSLDVQVSGQ----LRADPQLFRRALSNLLA 366
Cdd:PRK15347 450 ----INNLLDFSRIESGQmTL--SLEETALLplldqamltiqgpAQSKSLTLRTFVGAHvplyLHLDSLRLRQILVNLLG 523
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 367 NAIRYASADSlIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDaarSDAQSSGLGLAIVQAIMRLHGGRAE-A 445
Cdd:PRK15347 524 NAVKFTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAD---THSQGTGLGLTIASSLAKMMGGELTlF 599
|
330
....*....|....*...
gi 9951160 446 SAPAPGRiRFDLAFPAQD 463
Cdd:PRK15347 600 STPGVGS-CFSLVLPLNE 616
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
173-462 |
1.63e-07 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 53.48 E-value: 1.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 173 VLLA--FLGTALLgWLVLRHGLRPLRTLAAKAAEIHPTSLDTrLDvAAAPAELQQVAQSFNAMLERLDDGYQRLQQFSAD 250
Cdd:PRK10815 196 VLLAnlLLVIPLL-WLAAWWSLRPIEALAKQVRELEEGEREQ-LD-PNPPRELTSLVRNLNRLLKNERERYTKYRTTLTD 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 251 LAHEIRTPIGSLmghgQVALRQPRSNEEyqalIASNQEE---LERIARMVESILFLARaddvRAAVERSRLDLGEELRRQ 327
Cdd:PRK10815 273 LTHSLKTPLAVL----QSTLRSLRSGKQ----MSVEQAEpimLEQISRISQQIGYYLH----RASMRSEHNLLSRELHSV 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 328 AEYFEGLA-------EERGLSLDVQVSGQL-----RADpqlFRRALSNLLANAIRYASadSLIEVRGLRRSGEFLLSVEn 395
Cdd:PRK10815 341 APLLDNLTsalnkvyQRKGVNITLDISPEItfvgeKND---FMEVMGNVLDNACKYCL--EFVEISARQTDEHLHIVVE- 414
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 396 acDRLPAEPLSR---LFDRFYRGDAARSdaqSSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFPAQ 462
Cdd:PRK10815 415 --DDGPGIPESKrelIFDRGQRADTLRP---GQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGRQ 479
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
233-446 |
1.81e-07 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 53.44 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 233 MLERLDDgYQRLQQFSADLAHEIRTPIGSLMGHGQvaLRQPRSNEEYQA---LIASnqeELERIARMVESILFLARADDV 309
Cdd:COG5809 260 LLRKSEK-LSVVGELAAGIAHEIRNPLTSLKGFIQ--LLKDTIDEEQKTyldIMLS---ELDRIESIISEFLVLAKPQAI 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 310 RaaVERSrlDLGEELRRQAEYFEGLAEERGLSLDVQVSGQ---LRADPQLFRRALSNLLANAIRyASADS---LIEVRGL 383
Cdd:COG5809 334 K--YEPK--DLNTLIEEVIPLLQPQALLKNVQIELELEDDipdILGDENQLKQVFINLLKNAIE-AMPEGgniTIETKAE 408
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9951160 384 RRSGEFLLSVENACDrLPAEPLSRLFDRFY----RGdaarsdaqsSGLGLAIVQAIMRLHGGRAEAS 446
Cdd:COG5809 409 DDDKVVISVTDEGCG-IPEERLKKLGEPFYttkeKG---------TGLGLMVSYKIIEEHGGKITVE 465
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
216-460 |
5.32e-07 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 52.21 E-value: 5.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 216 VAAAPAELQQVAQSFNAMLERLDDGYQRLQQFSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALIASNQEELERIAR 295
Cdd:PRK11466 416 VKARTAELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTI 495
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 296 MVESILFLA-RADDVRAAVERSRLDLGEELRRQAEYFEGLAEERGLSLDVQVSGQ----LRADPQLFRRALSNLLANAIR 370
Cdd:PRK11466 496 LNDILDYSAiEAGGKNVSVSDEPFEPRPLLESTLQLMSGRVKGRPIRLATDIADDlptaLMGDPRRIRQVITNLLSNALR 575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 371 YASADSLIeVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSdaqSSGLGLAIVQAIMRLHGGRAEASAPAP 450
Cdd:PRK11466 576 FTDEGSIV-LRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKRG---GTGLGLTISSRLAQAMGGELSATSTPE 651
|
250
....*....|
gi 9951160 451 GRIRFDLAFP 460
Cdd:PRK11466 652 VGSCFCLRLP 661
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-460 |
5.56e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 47.78 E-value: 5.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 359 RALSNLLANAIRyASADSLIEV-------RGLRRSGE-----FLLSVENACDRLPAEPLSRLFDRFYRGDAarsdaQSSG 426
Cdd:cd16918 3 QVFLNLVRNAAQ-ALAGSGGEIilrtrtqRQVTLGHPrhrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGRE-----NGTG 76
|
90 100 110
....*....|....*....|....*....|....
gi 9951160 427 LGLAIVQAIMRLHGGRAEASApAPGRIRFDLAFP 460
Cdd:cd16918 77 LGLAIAQNIVSQHGGVIECDS-QPGHTVFSVSLP 109
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-441 |
2.19e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 46.74 E-value: 2.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 352 ADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAARSDA-QSSGLGLA 430
Cdd:cd16947 16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAkQGNGLGLT 95
|
90
....*....|.
gi 9951160 431 IVQAIMRLHGG 441
Cdd:cd16947 96 ITKRLAESMGG 106
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
353-460 |
2.50e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 45.99 E-value: 2.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 353 DPQLFRRALSNLLANAIRYASA--DSLIEVR---GLRRSGEFLLSVENACDRLPAEPLSRLFDRFyrgdaARSDAQSSGL 427
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGrpSDVGEVRirvEADQDGRIVLIVCDNGKGFPREMRHRATEPY-----VTTRPKGTGL 75
|
90 100 110
....*....|....*....|....*....|...
gi 9951160 428 GLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFP 460
Cdd:cd16944 76 GLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-460 |
9.39e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 44.31 E-value: 9.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 361 LSNLLANAIRYASAdslievrGLRRSGEFLLSVENACDR------------LPAEPLSRLFDRFYRgdaarSDAQSSGLG 428
Cdd:cd16920 5 LINLVRNGIEAMSE-------GGCERRELTIRTSPADDRavtisvkdtgpgIAEEVAGQLFDPFYT-----TKSEGLGMG 72
|
90 100 110
....*....|....*....|....*....|..
gi 9951160 429 LAIVQAIMRLHGGRAEASAPAPGRIRFDLAFP 460
Cdd:cd16920 73 LSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
246-462 |
1.28e-05 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 47.42 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 246 QFSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALIASnqeELERIARMVESILFLARADdvraAVERSRLDLGEELR 325
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDIMLS---ELDRIESIISEFLALAKPQ----AVNKEKENINELIQ 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 326 R-----QAE--------YFEGLAEERGLSLDVQvsgQLRadpQLFrralSNLLANA-----------IRYASADSLIEVR 381
Cdd:COG5805 362 DvvtllETEailhniqiRLELLDEDPFIYCDEN---QIK---QVF----INLIKNAieampnggtitIHTEEEDNSVIIR 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 382 glrrsgefllsVENACDRLPAEPLSRLFDRFYrgdaaRSDAQSSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAFPA 461
Cdd:COG5805 432 -----------VIDEGIGIPEERLKKLGEPFF-----TTKEKGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
.
gi 9951160 462 Q 462
Cdd:COG5805 496 S 496
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
361-457 |
2.54e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 43.21 E-value: 2.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 361 LSNLLANAIRYAS--ADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYrgdAARSDAQSSGLGLAIVQAIMRL 438
Cdd:cd16976 5 LMNLLQNALDAMGkvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF---TTKPVGKGTGLGLSISYGIVEE 81
|
90 100
....*....|....*....|.
gi 9951160 439 HGGRAE-ASAPAPG-RIRFDL 457
Cdd:cd16976 82 HGGRLSvANEEGAGaRFTFDL 102
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
340-459 |
3.52e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 43.39 E-value: 3.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 340 LSLDVQVSGQLRADPQLFRRALSNLLANAIRYAsaDSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYRGDAAR 419
Cdd:cd16954 21 ISLDISPELRFPGERNDLMELLGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQR 98
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 9951160 420 sdaQSSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLAF 459
Cdd:cd16954 99 ---PGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
343-441 |
4.53e-05 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 46.12 E-value: 4.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 343 DVQVSgqLRADPQLFRRALSNLLANAIRYASADSLI-EVRglRRSGEFLLSVENACDRLPAEPLSRLFDRFYR-GDAARS 420
Cdd:PRK10841 551 DVPVA--LNGDPMRLQQVISNLLSNAIKFTDTGCIVlHVR--VDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQvGTGVQR 626
|
90 100
....*....|....*....|.
gi 9951160 421 DAQSSGLGLAIVQAIMRLHGG 441
Cdd:PRK10841 627 NFQGTGLGLAICEKLINMMDG 647
|
|
| HAMP |
pfam00672 |
HAMP domain; |
186-239 |
7.65e-05 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 40.30 E-value: 7.65e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 9951160 186 LVLRHGLRPLRTLAAKAAEIHPTSLDTRLDVAAaPAELQQVAQSFNAMLERLDD 239
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDLDVRLPVSG-RDEIGELARAFNQMAERLRE 53
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
189-239 |
2.24e-04 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 38.77 E-value: 2.24e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 9951160 189 RHGLRPLRTLAAKAAEIHPTSLDTRLDVAAaPAELQQVAQSFNAMLERLDD 239
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDG-RDEIGELARAFNEMADRLEE 50
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
166-462 |
2.77e-04 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 43.51 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 166 RDRVIAAVLLAFLGT----ALLGWLVLRHGLRPLRTLaakaaeihPTSLDTRLDVAAAPAELQQVAQSFNAMLERLDDGy 241
Cdd:PRK13837 374 RRGPALWACLAFKSGdrivALLGLGRQRYGLRPPAGE--------LQLLELALDCLAHAIERRRLETERDALERRLEHA- 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 242 QRLQ---QFSADLAHEIRTPIGSLMGHGQVA---LRQPRSNEEYQALIASnqeELERIARMVESILFLARADDVRaaveR 315
Cdd:PRK13837 445 RRLEavgTLASGIAHNFNNILGAILGYAEMAlnkLARHSRAARYIDEIIS---AGARARLIIDQILAFGRKGERN----T 517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 316 SRLDLGEELRRQAEYFEgLAEERGLSLDVQVSGQ---LRADPQLFRRALSNLLANAIRYASADSLIEVR----------- 381
Cdd:PRK13837 518 KPFDLSELVTEIAPLLR-VSLPPGVELDFDQDQEpavVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISlsraklrapkv 596
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 382 ---GLRRSGEF-LLSVENACDRLPAEPLSRLFDRFYRgdaarSDAQSSGLGLAIVQAIMRLHGGRAE-ASAPAPGrIRFD 456
Cdd:PRK13837 597 lshGVLPPGRYvLLRVSDTGAGIDEAVLPHIFEPFFT-----TRAGGTGLGLATVHGIVSAHAGYIDvQSTVGRG-TRFD 670
|
....*.
gi 9951160 457 LAFPAQ 462
Cdd:PRK13837 671 VYLPPS 676
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
192-237 |
4.26e-04 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 37.81 E-value: 4.26e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 9951160 192 LRPLRTLAAKAAEIHPTSLDTRLDVAAaPAELQQVAQSFNAMLERL 237
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDLDVRVPVRS-KDEIGELARAFNQMAERL 45
|
|
| HATPase_AgrC-ComD-like |
cd16935 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-444 |
5.71e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.
Pssm-ID: 340412 [Multi-domain] Cd Length: 134 Bit Score: 39.87 E-value: 5.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 328 AEYFEgLAEERG--LSLDVQVSGQLRADPQLFRRALSNLLANAI----RYASADSLIEVRGLRRSGEFLLSVENACDrlp 401
Cdd:cd16935 7 SEKLE-LAREKGieFTIEIDIPILLPISPLDLCIIFGNLLDNAIeacaKIDKENRFIHLKIRQKKGFLIISIENSYE--- 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 9951160 402 aEPLSRLFDRFY--RGDAARsdaqssGLGLAIVQAIMRLHGGRAE 444
Cdd:cd16935 83 -GELKKKNGLFLstKKDKNH------GIGLKSIREIVKKYNGNLS 120
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
3-458 |
1.53e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 40.87 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 3 ARRSLTLYAALLFAAVAALVVSAVGFYLYRSVEEAMLRRSDVMVAGRVEHFRNLLRDNLTLAELKARPRLFENMLGNEQD 82
Cdd:COG2770 48 ALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 83 ILLLGQPGEAPIVAVNPRHERLPSLRVVAAGQALNPSVVHAALTHDGIPMRVLAAEVLVGGREPLQITAAHLLLGETRML 162
Cdd:COG2770 128 LAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAA 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 163 AQYRDRVIAAVLLAFLGTALLGWLVLRHGLRPLRTLAAKAAEIHPTSLDTRLDVAAAPaELQQVAQSFNAMLERLDDGYQ 242
Cdd:COG2770 208 LAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKD-EIGELARAFNRMADSLRESIE 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 243 RLQQFSADLAHEIRTPIGSLMGHGQVALRQPRSNEEYQALIASNQEELERIARMVESILFLARADDVRAAVERSRLDLGE 322
Cdd:COG2770 287 EAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALE 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 323 ELRRQAEYFEGLAEERGLSLDVQVSGQLRADPQLFRRALSNLLANAIRYASADSLIEVRGLRRSGEFLLSVENACDRLPA 402
Cdd:COG2770 367 LLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIA 446
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 9951160 403 EPLSRLFDRFYRGDAARSDAQSSGLGLAIVQAIMRLHGGRAEASAPAPGRIRFDLA 458
Cdd:COG2770 447 AAAAAEAEGGLAELEAEELVAAAEALLLLAALLLLAALGALELLLLEEEEEAGAAA 502
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
357-443 |
1.94e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 38.13 E-value: 1.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 357 FRRALSNLLANA---------------IRYASADSLIEVRGLRRSGEFLLSVENACDRLPAEPLSRLFDRFYrgdAARSD 421
Cdd:cd16919 1 LELAILNLAVNArdampeggrltietsNQRVDADYALNYRDLIPGNYVCLEVSDTGSGMPAEVLRRAFEPFF---TTKEV 77
|
90 100
....*....|....*....|..
gi 9951160 422 AQSSGLGLAIVQAIMRLHGGRA 443
Cdd:cd16919 78 GKGTGLGLSMVYGFVKQSGGHL 99
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
287-462 |
2.60e-03 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 39.60 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 287 QEELERIARMVESILflaraDDVRAAV------ERSRLDLGEELRRQAEYFEGLAeerGLSLDVQVSGQLRADPQLFR-- 358
Cdd:COG4585 91 REELEEIRELAREAL-----AELRRLVrglrppALDDLGLAAALEELAERLLRAA---GIRVELDVDGDPDRLPPEVEla 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 359 --RALSNLLANAIRYASADSlIEVRGLRRSGEFLLSVENACDRLPAEPLSRlfdrfyrgdaarsdaqsSGLGLAIVQAIM 436
Cdd:COG4585 163 lyRIVQEALTNALKHAGATR-VTVTLEVDDGELTLTVRDDGVGFDPEAAPG-----------------GGLGLRGMRERA 224
|
170 180
....*....|....*....|....*.
gi 9951160 437 RLHGGRAEASAPAPGRIRFDLAFPAQ 462
Cdd:COG4585 225 EALGGTLTIGSAPGGGTRVRATLPLA 250
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
360-445 |
3.16e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 36.86 E-value: 3.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 360 ALSNLLANAIRYASADS---LIEVRGLRRSGEFLLSVenaCDRLPAEPLSRLFDRfyrgdaaRSDAQSSGLGLAIVQAIM 436
Cdd:cd16936 4 AVSEAVTNAVRHAYRHDgpgPVRLELDLDPDRLRVEV---TDSGPGFDPLRPADP-------DAGLREGGRGLALIRALM 73
|
....*....
gi 9951160 437 RLHGGRAEA 445
Cdd:cd16936 74 DEVGYRRTP 82
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
334-441 |
7.53e-03 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 38.77 E-value: 7.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951160 334 LAEERGLSLDVQVSGQL----RADPQLFRRALSNLLANAIRYaSADSLIEVRGLRRSGEFLL-SVENACDRLPAEPLSRL 408
Cdd:PRK11091 372 QAEQKGLRFDLEPLLPLphkvITDGTRLRQILWNLISNAVKF-TQQGGVTVRVRYEEGDMLTfEVEDSGIGIPEDELDKI 450
|
90 100 110
....*....|....*....|....*....|....*
gi 9951160 409 FDRFY--RGDAARSDAQSSGLGLAIVQAIMRLHGG 441
Cdd:PRK11091 451 FAMYYqvKDSHGGKPATGTGIGLAVSKRLAQAMGG 485
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