|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
21-422 |
5.23e-88 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 273.63 E-value: 5.23e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 21 KTLSLSALGGALEFYDFIIFVFFATVV-GKLFFPADMPEwLRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLS 99
Cdd:cd17369 2 RVALASLVGTAIEWYDFFIYGTAAALVfNKLFFPAVDPA-AGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 100 IFMMAVPTLIMGLLPTYAQIGIWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLV 179
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 180 ATAINSFYSATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKAlAEEVPLKAVVRDHRGAVLVSMLLTWV 259
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQ-VVRAPLVEVLRRHWRALLLAIGLRLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 260 LSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLALVSWSFYGNLKAHP 339
Cdd:cd17369 240 ENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 340 DWLFPLYALTGFFVG---IVGAVPYVMVNAFPPVVRFSGLSFSYNLAYAIFGGLTPMAVALLLKQ--SPMGPAYYVVTLC 414
Cdd:cd17369 320 TWLIVLAAVVVLGVLhgmMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAAtgSWWPVALYLAALA 399
|
....*...
gi 9951692 415 LVGFLVGL 422
Cdd:cd17369 400 VISLVAAL 407
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
29-418 |
4.20e-78 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 247.57 E-value: 4.20e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 29 GGALEFYDFIIFVFFATVVGKLFFPADMPEWLRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTL 108
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 109 IMGLLPTYAQIGIWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYS 188
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 189 ATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKALAeEVPLKAVVRDHRGAVLVSMLLTWVLSAAIVVVI 268
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKK-RGPIAETLTKHRKPFLLGLGLVIATTTTFYLIT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 269 LMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLALVSWSFYGNLKAHPD---WLFPL 345
Cdd:TIGR00883 240 TYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSftlFFFLV 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9951692 346 YALTGFFVGIVGAVPYVMVNAFPPVVRFSGLSFSYNLAYAIFGGLTPMaVALLLK---QSPMGPAYYVVTLCLVGF 418
Cdd:TIGR00883 320 LGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPY-IAAALVamtGDWYAIGYYLAALALIGL 394
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
27-420 |
2.29e-73 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 235.65 E-value: 2.29e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 27 ALGGALEFYDFIIFVFFATVVGKLFFPADMPEwLRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVP 106
Cdd:cd17367 5 SVGNLVEWYDWYVYAAFALYFAPQFFPSGDPT-VALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 107 TLIMGLLPTYAQIGIWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSF 186
Cdd:cd17367 84 SLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQHT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 187 YSATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKAlAEEVPLKAVVRdHRGAVLVSMLLTWVLSAAIVV 266
Cdd:cd17367 164 LGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNE-ASAGTLRELRR-HPRELLLVVGLTAGGTLAFYT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 267 VILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLALVSWSFYGNLKAHPDWLFply 346
Cdd:cd17367 242 WTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYT--- 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 347 ALTGFFVGIVGAVPYVMVNA------FPPVVRFSGLSFSYNLAYAIFGGLTPMaVALLLKQSPMGPAY--YVVTLCLVGF 418
Cdd:cd17367 319 AFALVLVGLVFLSGYTSINAvvkaelFPTHVRALGVGLPYALAVAIFGGTAPY-VALWLKSIGHEWVFfwYVAGLIAISL 397
|
..
gi 9951692 419 LV 420
Cdd:cd17367 398 VV 399
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
23-422 |
2.77e-66 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 215.54 E-value: 2.77e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 23 LSLSALGGALEFYDFIIFVFFATVVGKLFfpadmPEWLRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFM 102
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 103 MAVPTLIMGLLPTyaqigiwaPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATA 182
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 183 INSFYSatevQDYAWRIPFLLGGVFGLFSVYLRRWlhetpvfaelqqrkalaeevplkavvrdhrgaVLVSMLLTWVLSA 262
Cdd:cd17316 148 LIPLLS----GDWGWRILFLIGALPALLALLLRRR--------------------------------TLLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 263 AIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLALVSWSFYGNLKAHPDWL 342
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 343 FPLYALTGFFVGIVGAVPYVMVNA-FPPVVRFSGLSFSYNLAYAIFGGLTPMAVALLLKQSPMG-PAYYVVTLCLVGFLV 420
Cdd:cd17316 272 LLLLFILSFFVGGVWGALYAYLAElFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGvPALILALLAIVALIV 351
|
..
gi 9951692 421 GL 422
Cdd:cd17316 352 AL 353
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
26-424 |
6.09e-65 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 212.99 E-value: 6.09e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 26 SALGGALEFYDFIIFVFFATVVGKLFFPADMPEWlRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAV 105
Cdd:cd17366 4 AALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTA-QLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 106 PTLIMGLLPTYAQIGIWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINS 185
Cdd:cd17366 83 STFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 186 FYSATEVQDYAWRIPFLLGGVFGLFSVYLRRwlhetpvfaelqqrkalaeevplkavvrdhrgAVLVSMLLTWVLSAAIV 265
Cdd:cd17366 163 LLTEAQMLDWGWRIPFLIAAPLGLVGLYLRR--------------------------------PLLICIGLVLVFNVTNY 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 266 VVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLALVSWSFYGNLKAHPDW--LF 343
Cdd:cd17366 211 MLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSIAaiFI 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 344 PLYALTGFFVGIVGAVPYVMVNAFPPVVRFSGLSFSYNLAYAIFGGLTPMAVALLLKQS--PMGPAYYVVTLCLVGFLVG 421
Cdd:cd17366 291 GLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATgnPLMPAYYLMVAAVVGLVAV 370
|
...
gi 9951692 422 LYL 424
Cdd:cd17366 371 LFL 373
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
26-424 |
2.05e-64 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 212.62 E-value: 2.05e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 26 SALGGALEFYDFIIFVFFATVVGKLFFPADmPEWLRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAV 105
Cdd:cd17368 4 ATSGNALEFFDFGVYGFFAVYIGRLFFPSG-SEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 106 PTLIMGLLPTYAQIGIWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINS 185
Cdd:cd17368 83 GTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 186 FYSATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAElqqRKALAEEVPLKAVVRDHRGAVLVSMLLTWVLSAAIV 265
Cdd:cd17368 163 TLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLE---RKARPTRRELFALLANNRRIILLGMLLVAGSTVTFY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 266 VVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLALVSWSFYGNLKAHPD---WL 342
Cdd:cd17368 240 FTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSfgrLL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 343 FPLYALTGFFVGIVGAVPYVMVNAFPPVVRFSGLSFSYNLAYAIFGGLTPMAVALL--LKQSPMGPAYYVVTLCLVGFLV 420
Cdd:cd17368 320 LVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLieLTGSPLAPAWYLMGAALLGLLA 399
|
....
gi 9951692 421 GLYL 424
Cdd:cd17368 400 TLML 403
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
21-424 |
2.75e-59 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 201.48 E-value: 2.75e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 21 KTLSLSALGGALEFYDFIIFVFFATVVGKLFFPADMPEwLRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSI 100
Cdd:PRK10642 16 KAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPS-VQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 101 FMMAVPTLIMGLLPTYAQIGIWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVA 180
Cdd:PRK10642 95 VIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 181 TAINSFYSATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVF------AELQQRKALAE--EVPLKAVVRDHRGAVLV 252
Cdd:PRK10642 175 VLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFqqhvdkLEQGDREGLQDgpKVSFKEIATKHWRSLLT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 253 SMLLtwVLSAAIVVVILMT--PTVLQSVYGFDAATALkansLAIVCLTLGCI----VAGRMADRYGAGLTFVAGSVLLAL 326
Cdd:PRK10642 255 CIGL--VIATNVTYYMLLTymPSYLSHNLHYSEDHGV----LIIIAIMIGMLfvqpVMGLLSDRFGRRPFVILGSVALFV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 327 VSWSFYGNLKAHPDW-----LFPLYALTGFFVGIVGAVPYVMvnaFPPVVRFSGLSFSYNLAYAIfGGLTPMAVALLLK- 400
Cdd:PRK10642 329 LAIPAFILINSNVIGlifagLLMLAVILNCFTGVMASTLPAM---FPTHIRYSALAAAFNISVLV-AGLTPTLAAWLVEs 404
|
410 420
....*....|....*....|....*
gi 9951692 401 -QSPMGPAYYVVTLCLVGFLVGLYL 424
Cdd:PRK10642 405 tQNLMMPAYYLMVVAVIGLITGVTM 429
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
1-427 |
3.41e-45 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 162.59 E-value: 3.41e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 1 MPSANAPEAPAQRPLTRSDYKTLSLSALGGA-LEFYDFIIF-VFFATVVGKLFFPADMPEwLRQLQTFGLFAAGYLARPL 78
Cdd:PRK09952 1 MDSTLISTRPDEGTLSLSRARRAALGSFAGAvVDWYDFLLYgITAALVFNREFFPQVSPA-MGTLAAFATFGVGFLFRPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 79 GGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQIGIWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHV 158
Cdd:PRK09952 80 GGVVFGHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 159 GYACGTLTSGLTAGILLGSLVATAINSFYSATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKALAE-EV 237
Cdd:PRK09952 160 AFYSSGVQVGYGVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKkRI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 238 PLKAVVRDHRGAVL--VSMLLTWVLSAAIVVVILMTPTVlqSVYGFDAATALKANSL--AIVCLTLGCIvaGRMADRYGA 313
Cdd:PRK09952 240 PVIEALLRHPGAFLkiIALRLCELLTMYIVTAFALNYST--QNLGLPRELFLNIGLLvgGLSCLTIPCF--AWLADRFGR 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 314 GLTFVAGSVLLALVSWSFYGNLKAHPDWLFPLYA--LTGFFVGIVGAVPYVMVNA-FPPVVRFSGLSFSYNLAYAIFGGL 390
Cdd:PRK09952 316 RRVYITGALIGTLSAFPFFMALEAQSIFWIVFFSimLANIAHDMVVCVQQPMFTEmFGASYRYSGAGVGYQVASVVGGGF 395
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 9951692 391 TPMAVALLLKQSP---MGPAYYVVTLCLVGFLVGLYLLAQ 427
Cdd:PRK09952 396 TPFIAAALVTYFGgswHSVAIYLLAGCLISAMTALLMKDN 435
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
9-424 |
4.46e-45 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 162.03 E-value: 4.46e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 9 APAQRPLTRSDYKTLSLSALGGALEFYDFIIFVFFATVVGKLFFPADmPEWLRQLQTFGLFAAGYLARPLGGVIMAHFGD 88
Cdd:PRK15075 3 TMTPAASRESKARAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAG-NEFASLMLTFAVFGAGFLMRPLGAIVLGAYID 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 89 LLGRKR--MFTLSIfmMAVPTLIMGLLPTYAQIGIWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLT 166
Cdd:PRK15075 82 RVGRRKglIVTLSI--MASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 167 SGLTAGILLGSLVATAINSFYSATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKALAEevpLKAVVRDH 246
Cdd:PRK15075 160 ASQQVAVVFAALLGYLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMRE---IFRSLAAN 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 247 RGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALkansLAIVCLTLGCI----VAGRMADRYGAGLTFVAGSV 322
Cdd:PRK15075 237 WRIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLSAADSL----LVTLCVGVSNFiwlpIGGALSDRIGRRPVLIAFTV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 323 LLALVSWSFYGNLKAHPD---------WLFPLYaltGFFVG-IVGAVPYVMvnafPPVVRFSGLSFSYNLAYAIFGGLTP 392
Cdd:PRK15075 313 LAILTAYPALSWLVAAPSfarmlavelWLSFLY---GSYNGaMVVALTEVM----PAEVRTAGFSLAYSLATAIFGGFTP 385
|
410 420 430
....*....|....*....|....*....|....
gi 9951692 393 MAVALLLKQS--PMGPAYYVVTLCLVGFLVGLYL 424
Cdd:PRK15075 386 AISTWLIHVTgdKAAPGYWLSFAAVCGLIATLVL 419
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
29-424 |
2.12e-43 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 157.66 E-value: 2.12e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 29 GGALEFYDFIIFVFFATVVGKLFFPADMPEwLRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTL 108
Cdd:PRK10406 30 GNLVEWFDFYVYSFCSLYFAHIFFPSGNTT-TQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMMCFGSL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 109 IMGLLPTYAQIGIWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYS 188
Cdd:PRK10406 109 VIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQQTLE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 189 ATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETpvfaELQQRKALAEEVPLKAVVRdHRGAVLVSMLLTWVLSAAIVVVI 268
Cdd:PRK10406 189 DAELREWGWRIPFALGAVLAVVALWLRRQLDET----SQQETRALKEAGSLKGLWR-NRRAFIMVLGFTAAGSLCFYTFT 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 269 LMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLALVSWSFYGNLK--AHPDWLFPLY 346
Cdd:PRK10406 264 TYMQKYLVNTAGMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAALFTVPILSALQnvSSPYAAFGLV 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 347 AL----TGFFVGIVGAVPYVMvnaFPPVVRFSGLSFSYNLAYAIFGGlTPMAVALLLKQSPMGPAY--YVVTLCLVGFLV 420
Cdd:PRK10406 344 MCalliVSFYTSISGILKAEM---FPAQVRALGVGLSYAVANALFGG-SAEYVALSLKSIGMETAFfwYVTLMAVVAFLV 419
|
....
gi 9951692 421 GLYL 424
Cdd:PRK10406 420 SLML 423
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
25-425 |
1.57e-32 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 127.03 E-value: 1.57e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 25 LSALGGALEFYDFIIFVFFAtvvgklffPADMPEW-LRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMM 103
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVL--------PALIAEFgLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 104 AVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAI 183
Cdd:cd17371 75 AVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 184 NSFYSATEvqdyAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKALAEEVPLKAVV--RDHRGAVLVSMLLTWVLS 261
Cdd:cd17371 147 FPLLPPEI----AWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELfsPPLLRTTLLASLLATGAL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 262 AAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSvLLALVSWSFYGNLKAHPDW 341
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFA-LGSAISILLYFFLPLSPTL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 342 LFPLYALTGFFV-GIVGAVPYVMVNAFPPVVRFSGLSFSYNLAYAIfGGLTPMAVALLLKQSPMGPAyyVVTLCLVGFLV 420
Cdd:cd17371 302 ILILGFPLGFFAsGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFLATSGSLGTA--IAVFAAVYYIA 378
|
....*
gi 9951692 421 GLYLL 425
Cdd:cd17371 379 GLVLA 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-434 |
3.77e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 109.20 E-value: 3.77e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 20 YKTLSLSALGGALEFYDFIIFVFFATVVGKLF-FPADmpewlrqlQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTL 98
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFgLSAA--------QLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 99 SIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSL 178
Cdd:COG2223 76 GLLLLGIGLLLLALAVSYWL--------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 179 VATAInsfysateVQDYAWRIPFLL-GGVFGLFSVYLRRWLHETPVFAELQQRKALAEevpLKAVVRDHRgaVLVSMLLT 257
Cdd:COG2223 148 LAPLL--------IAAFGWRNAFLIlGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD---QLEALRDPR--FWLLSLLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 258 WVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLALVSWSFyGNLKA 337
Cdd:COG2223 215 FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL-ALALG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 338 HPDWLFPLYALTGFFVGIV-GAVPYVMVNAFPPVVRFSGLSFSYnLAYAIFGGLTPMAVALLLKQ--SPMGPAYYVVTLC 414
Cdd:COG2223 294 SLWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVG-AAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLA 372
|
410 420
....*....|....*....|
gi 9951692 415 LVGFLVGLYLLAQKKPAGEA 434
Cdd:COG2223 373 LVALVLTLLLYRRPRRAAAA 392
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
12-381 |
1.03e-22 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 99.35 E-value: 1.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 12 QRPLTRSDYKTLSLSALGGALEFYDFIIFVFFAtvvgklffPADMPEWLRQLQTFG-LFAAGYLARPLGGVIMAHFGDLL 90
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAA--------PAISAEWGLDPVQLGfLFSAGLIGMAFGALFFGPLADRI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 91 GRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLT 170
Cdd:TIGR00895 80 GRRRVLLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 171 AGILLGslvatainSFYSATEVQDYAWRIPFLLGGVFGLF-SVYLRRWLHETPVFAELQ----------------QRKAL 233
Cdd:TIGR00895 152 IGAAVG--------GFLAGWLIPVFGWRSLFYVGGIAPLLlLLLLMRFLPESIDFLVSKrpetvrrivnaiapqmQAEAQ 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 234 AEEVPLKAVVRDHRGAVLV--------SMLLTWVLSAAIVVVILMTPT---VLQSVYGFDAATALKANSLAIVCLTLGCI 302
Cdd:TIGR00895 224 SALPEQKSTQGTKRSVFKAlfqgktarITVLLWLLYFMLLVGVYFLTNwlpKLMVELGFSLSLAATGGALFNFGGVIGSI 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 303 VAGRMADRYGAGLTFV---AGSVLLALVSWSFYgnlkaHPDWLFPLYALTGFFV-GIVGAVPYVMVNAFPPVVRFSGLSF 378
Cdd:TIGR00895 304 IFGWLADRLGPRVTALlllLGAVFAVLVGSTLF-----SPTLLLLLGAIAGFFVnGGQSGLYALMALFYPTAIRATGVGW 378
|
...
gi 9951692 379 SYN 381
Cdd:TIGR00895 379 AIG 381
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
2-422 |
1.35e-22 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 99.77 E-value: 1.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 2 PSANAPEAPAQRPLTRSDYKTLSLSALGGALEFYDFIIFVFFATVVGKLFfpadmpeWLRQLQTFGLFAAGYLARPLGGV 81
Cdd:PRK03893 1 MSTTTQNIPWYRHLNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEF-------GLTTVQAASLISAAFISRWFGGL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 82 IMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYA 161
Cdd:PRK03893 74 LLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYW--------TLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 162 CGTLTSGLTAGILLGSLVATAInsfysateVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKA--------- 232
Cdd:PRK03893 146 SGFLISGFSIGAVVAAQVYSLV--------VPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKApvrtmvdil 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 233 -------------LAEEVPLKAVVRDHRGAVLVSMLLT------------------WVLSAAIVVVIL-----------M 270
Cdd:PRK03893 218 yrgehriinilltLAAAAALWFCFAGNLQNAAIVAVLGllcaaifisfmvqssgkrWPTGVMLMVVVLfaflyswpiqaL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 271 TPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVaGSVLLALVswsfygnlkahpdWLFPLYALTG 350
Cdd:PRK03893 298 LPTYLKTDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYV-CSLLISQL-------------LIIPVFAIGG 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 351 ----------FFV-----GIVGAVPYVMVNAFPPVVRFSGLSFSYNLAyAIFGGLTPMAVALLLKQSPMGPAYYVVTLCL 415
Cdd:PRK03893 364 anvwvlglllFFQqmlgqGISGLLPKLIGGYFDTEQRAAGLGFTYNVG-ALGGALAPILGALIAQRLDLGTALASLSFSL 442
|
490
....*....|
gi 9951692 416 ---VGFLVGL 422
Cdd:PRK03893 443 tfvVILLIGL 452
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
68-390 |
2.66e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 97.35 E-value: 2.66e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 68 LFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWV 147
Cdd:COG2814 50 VVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--------LLAARFLQGLGAGALFPAALA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 148 FVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFS-VYLRRWLHETPVFAE 226
Cdd:COG2814 122 LIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG--------WRWVFLVNAVLALLAlLLLLRLLPESRPAAR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 227 LQQRKALAEEVplkavvrdHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGR 306
Cdd:COG2814 194 ARLRGSLRELL--------RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 307 MADRYGAGLTFVAGSVLLALVSWSFygNLKAHPDWLFPLYALTGFFVGIVGAVPYVMV-NAFPPVVRFSGLSFsYNLAYA 385
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLLLL--ALAGSLWLLLLALFLLGFGFGLLFPLLQALVaELAPPEARGRASGL-YNSAFF 342
|
....*
gi 9951692 386 IFGGL 390
Cdd:COG2814 343 LGGPL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-430 |
4.78e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 96.86 E-value: 4.78e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 12 QRPLTRSDYKTLSLSALGGALEFYDFIIFVFFATVVGKLFFPADMpewlrqlQTFGLFAAGYLARPLGGVIMAHFGDLLG 91
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAA-------QLGLLASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 92 RKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTA 171
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 172 GILLGSLVATAInsfysateVQDYAWRIPFLLGGVFGLFSVYLRRWLhetpvfaelqqrkalaeevplkavvrdhrgAVL 251
Cdd:COG2271 146 GGALAPPLLGWL--------LAAFGWRAAFLILGLPGLLLALLRFWL------------------------------LAL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 252 VSMLLTWVLSAaivvVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGA-GLTFVAGSVLLALVSWS 330
Cdd:COG2271 188 AYFLVYFALYG----FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrRKLVLAIGLLLAALALL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 331 FYGNLkAHPDWLFPLYALTGFFVGIVGAVPYVMV-NAFPPVVRFSGLSFsYNLAYAIFGGLTPMAVALLLKQSPMGPAYY 409
Cdd:COG2271 264 LLALL-PSPALAIALLFLAGFGLGGAFGLLWALAaELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
410 420
....*....|....*....|.
gi 9951692 410 VVTLCLVGFLVGLYLLAQKKP 430
Cdd:COG2271 342 LLAALALLAALLALLLLRETR 362
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-325 |
9.08e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 94.88 E-value: 9.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 16 TRSDYKTLSLSALGGALEFYDFIIFVFFATVVGKLFFPAdmpewLRQLQTfgLFAAGYLARPLGGVIMAHFGDLLGRKRM 95
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGAS-----SAQLGW--IVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 96 FTLSIFMMAVPTLIMGLLPTyaqigiwaPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILL 175
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLAL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 176 GSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKALAEEVPLKAVVRDHRGAVLVSML 255
Cdd:COG0477 154 GPLLGGLLVAALG--------WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLL 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 256 LTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLA 325
Cdd:COG0477 226 LLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
68-426 |
1.13e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 87.25 E-value: 1.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 68 LFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWV 147
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLLARFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 148 FVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFSVYLR-RWLHETPVFAE 226
Cdd:cd17325 108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG--------YRAPFLVCAALALLALVLAlLLLPEPRPPPN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 227 LQQRKALAEEVPLKAVVRDHRgaVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGR 306
Cdd:cd17325 180 KRAVSAARLRSGLRLLLRDRR--LLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 307 MADRYGAGLTFVAGSVLLALVSWSFYgnLKAHPDWLFPLYALTGFFVGIVGAVPYVMV-NAFPPVVRFSGLSFsYNLAYA 385
Cdd:cd17325 258 LSDRIGRKPLILIGLLLSAVALLLLP--LATSFWLLLLLLALLGLGLGLVFPATLALLaDIVPPEGRGTAMGL-FNTAFS 334
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 9951692 386 IFGGLTPMAVALLLKQSPMGPAYYVVTLCLVGFLVGLYLLA 426
Cdd:cd17325 335 LGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
78-396 |
1.90e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 80.29 E-value: 1.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 78 LGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGAWVFVAEHVPARH 157
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 158 VGYACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFS-VYLRRWLHETPVFAELQQRKALAEE 236
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG--------WRAAFLAIAVLALLAaLLLWRLLPSLPPKKPGSLGLLSSLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 237 VPLKavvrdhRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLT 316
Cdd:cd17324 193 LLLR------NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRAL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 317 FVAGSVLLALVSWSFYGNlkAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPVVR---FSGLSFSYNLAYAIFGGLTPM 393
Cdd:cd17324 267 LIALLLLAAALLLLTLLG--PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARglaSSLYLAAYNLGGALGAALGGL 344
|
...
gi 9951692 394 AVA 396
Cdd:cd17324 345 VLD 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
68-392 |
7.80e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.23 E-value: 7.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 68 LFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYaqigiwapLALLLLRVIQGAAIGGEVPGAWV 147
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--------WLLLVLRVLQGLGAGALFPAALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 148 FVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFSVYLrrWLHETPVFAEL 227
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--------WRAAFLILAILSLLAAVL--LLLPRPPPESK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 228 QQRKALAEEVPLKAVVRDHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRM 307
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 308 ADRYGAGLTFVAGSVLLALVSWSF-YGNLKAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPVVRFSGLSFSYNLAYAI 386
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLlLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
|
....*.
gi 9951692 387 FGGLTP 392
Cdd:pfam07690 339 GGALGP 344
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
27-420 |
2.11e-15 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 77.70 E-value: 2.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 27 ALGGALEFYDFIIFVFFATVVGKLFFP-------ADMPEWLRQLQTFGLFAAGylaRPLGGVIMAHFGDLLGRKRMFTLS 99
Cdd:pfam00083 6 ALGGFLFGYDTGVIGAFLTLIDFFKNFglsksvsSLAALSVLSGLIVSIFSVG---CFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 100 IFMMAVPTLIMGLLPTYaqigiWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLV 179
Cdd:pfam00083 83 NVLFVIGAVLQGAAKGK-----WSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 180 ATAINSFYSATevqdyAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKALAEEV---------------------- 237
Cdd:pfam00083 158 GLGLNKTSNSD-----GWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVlaklrgvpdvdreldeikdsle 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 238 -----------PLKAVVRDHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVyGFDaaTALKANSLAIVCLTLGCIVAGR 306
Cdd:pfam00083 233 agqeaekaswkELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENL-GLS--DSFLVTIIVGVVNFVFTFIAIF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 307 MADRYGAGLTFVAGSVLLALVSWSFYG---NLKAHPDWLFPLyALTGFFVGI------VGAVPYVMV-NAFPPVVRFSGL 376
Cdd:pfam00083 310 LVDRFGRRPLLLLGAAGMAICFVILGIvalLGVSKSDWAGIV-AIVFIALFIaffamgWGPVPWVIVsELFPLSVRSKAM 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 9951692 377 SFSYNlAYAIFGGLTPMAVALLLKQSPMGPAYYVVTLCLVGFLV 420
Cdd:pfam00083 389 ALATA-ANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFII 431
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
68-424 |
3.67e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 73.61 E-value: 3.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 68 LFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYaqigiwapLALLLLRVIQGAAIGGEVPGAWV 147
Cdd:cd06174 36 LFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 148 FVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSATevqdyaWRIPFLLGGVFGLFSVYLRRWLHETPVFAEL 227
Cdd:cd06174 108 LIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG------WRAVFLIAAALALLAAILLLLVVPDPPESAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 228 QQRKALAEEVPLKAVVRDHRGAVLVSMLLTWVL-SAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGR 306
Cdd:cd06174 182 AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLvNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 307 MADRYGAGLTFVAGSVLLALVSWSFYGnLKAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPVVRFSGLSFSYNLAYAI 386
Cdd:cd06174 262 LSDRLIGRKPLLLIGLLLMALGLALLL-LAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL 340
|
330 340 350
....*....|....*....|....*....|....*...
gi 9951692 387 FGGLTPMAVALLLKQSPMGPAYYVVTLCLVGFLVGLYL 424
Cdd:cd06174 341 GGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
37-379 |
9.37e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 66.07 E-value: 9.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 37 FIIFVF--FATVVGKLFFPADMPEWLRQLQTFG-LFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLL 113
Cdd:cd17365 5 FLIIVLdgFDLAVMGFVAPALAQDWGLSPAQLGpVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 114 PTyaqigiwaPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAInsfysateVQ 193
Cdd:cd17365 85 QS--------VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAAL--------IP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 194 DYAWRIPFLLGGVFGLFSVYLrrwlhetpvfaelqqrkalaeevplkavvrdhrgavLVSMLLTWVLSAAIVVVILM--- 270
Cdd:cd17365 149 AFGWRSVFLLGGVPPLILLPL------------------------------------LRGTLLLWVTFFMGLLLVYLlns 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 271 -TPTVLQSVyGFDAATALKANSLAIVCLTLGCIVAGRMADRYGA----GLTFVAGSVLLALVswsfyGNLKAHPDWLFPL 345
Cdd:cd17365 193 wLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPkrvlALFFALGAVSLALL-----GVSPASLVLLYVL 266
|
330 340 350
....*....|....*....|....*....|....*
gi 9951692 346 YALTGFFV-GIVGAVPYVMVNAFPPVVRFSGLSFS 379
Cdd:cd17365 267 VFLAGACVnGAQVGLYALAARFYPTEVRATGVGWA 301
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
10-420 |
1.50e-11 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 65.72 E-value: 1.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 10 PAQRPLTRSDYKTLSLSALGGALEFYDFIIFVFFATVVgklffPADMPewLRQLQTFGLFAAGYLARPLGGVIMAHFGDL 89
Cdd:PRK12307 7 PWYSEITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLI-----KADLG--LTDMEGAFLATAAFIGRPFGGALFGLLADK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 90 LGRKRMFTLSIFMMAVPTLIMGLLPTYaqigiwapLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGL 169
Cdd:PRK12307 80 FGRKPLMMWSIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 170 TAGILLGslvATAINSFYSAtevqdYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAE--------LQQRKALAEEVPLKA 241
Cdd:PRK12307 152 GIGNIIA---AYFMPSFAEA-----YGWRAAFFVGLLPVLLVIYIRARAPESKEWEEaklsgkgkHSQSAWSVFSLSMKG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 242 VVRD-HRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSvYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAG 320
Cdd:PRK12307 224 LFNRaQFPLTLCVFIVLFSIFGANWPIFGLLPTYLAG-EGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 321 SVLLALVSWS-FYGNLKAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPVVRFSGLSFSYNLAyAIFGGLTPMAVALLL 399
Cdd:PRK12307 303 LLMSFLFIFPlFRIPQDNYLLLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLA-ATSGTFNSMAATWLG 381
|
410 420
....*....|....*....|.
gi 9951692 400 KQSPMGPAYYVVTLCLVGFLV 420
Cdd:PRK12307 382 ITMGLGAALTFIVAFWTATIL 402
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
86-356 |
3.00e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 64.52 E-value: 3.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 86 FGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTL 165
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 166 TSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFSVY----LRRWLHETPVFAelqqrkalaeevplka 241
Cdd:cd17503 126 GLVILLAPAIGPTLGGWLTDNLS--------WRWIFYINLPIGILALLlaplLDLRLFKDRNFT---------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 242 vvrdhrgavlVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGS 321
Cdd:cd17503 182 ----------LGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251
|
250 260 270
....*....|....*....|....*....|....*.
gi 9951692 322 VLLALVSWSFYGNLKAHPDWLFPL-YALTGFFVGIV 356
Cdd:cd17503 252 LLLALGTLLLAFLTPDTSLWLIILpLFIRGLGMGLV 287
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
81-425 |
6.41e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 63.73 E-value: 6.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 81 VIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTyaqigiwaPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGY 160
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 161 ACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFSVYLrrwlheTPVFaelqqrkalaeevplk 240
Cdd:cd17321 121 ALGLWGAVVGIGAALGPLLGGLLLELFG--------WRWIFLINVPIGLVALLL------ARTF---------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 241 avvrdhRGAVLVSMLltwvLSAAIVVVILMTPTVLQSVYGFDAATAlkanSLAIVCLTLGCIV----AGRMADRYGAGLT 316
Cdd:cd17321 171 ------SGAVLAAFL----LGAALGGLLFLLPLYLQGVLGYSPLQA----GLALLPLALAMLVaaplAGRLADRFGPRLV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 317 FVAGSVLLALVSWSFYGNLKAHPDW-LFPLYALTGFFVGI-VGAVPYVMVNAFPP-----------VVRFSGLSFSYNLA 383
Cdd:cd17321 237 LVAGLLLTAVGLLLLALLGADSSVWlLLPGLVLLGLGLGLfATPLTNAALSSVPKekagaasgilnTARQLGGALGVALL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 9951692 384 YAIFGGLTPMAVALLLKQSPMGPA------------YYVVTLCLVGFLVGLYLL 425
Cdd:cd17321 317 GALLTAGLSANLGDSGVAALLSAAaaafaagfhlafLVAAALALLAALLALLLP 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
66-424 |
3.55e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.97 E-value: 3.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 66 FGLFAAGYLarpLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLlptyaqigIWAPLALLLLRVIQGAAIGGEVPGA 145
Cdd:cd17319 44 ASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF--------ATSLTSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 146 WVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFSVYLRRWLHetpvfa 225
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG--------WRWAFIIEGLLGLLLAVLWWFYL------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 226 elqqrkalaeevplkavvrdhrGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAG 305
Cdd:cd17319 179 ----------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 306 RMADRY--GAGLTFVAGSVLLALVSWSFYGNLkAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPVVRFSGLSFSYNLA 383
Cdd:cd17319 237 RLSDRLlrGARRLVIIIGLLLAAVGLLLAYLT-TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 9951692 384 YAIFGGLTPMAVALLLKQ--SPMGPAYYVVTLCLVGFLVGLYL 424
Cdd:cd17319 316 GNLGGFVAPLLIGYLVDAtgSYTAAFLFLAAVALLAALLVLLL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
68-433 |
4.85e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.94 E-value: 4.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 68 LFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGAWV 147
Cdd:COG0738 48 LLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP--------LLLLALFLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 148 FVAEHVPARHvgyacGTLTSGLTAGILLGSLVATAINSFYSATEVqDYAWRIPFLLGGV--FGLFSVYLRRWLHETpvfa 225
Cdd:COG0738 120 YVAALGPETA-----ASRLNLLHAFFSLGALLGPLLGGLLILLGL-SLSWHLPYLILAVllLLLALLFLRSKLPEI---- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 226 ELQQRKALAEEVPLKAVVRdhRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAG 305
Cdd:COG0738 190 EEEEEEAAGSAASLKSLLK--NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 306 RMADRYGAGLTFVAGSVLLALVSWSFYgnLKAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPvvRFSGLSFSYNLAYA 385
Cdd:COG0738 268 FLLKRFGPVRLLRLSALLAAVGLLLAL--LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLG--KRTAAAVSAVLIMG 343
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 9951692 386 IFGGLT-PMAVALLLKQSPMGPAYYVVTLCLVgFLVGLYLLAQKKPAGE 433
Cdd:COG0738 344 IVGGAIgPPLIGFLADAFGLRAAFLVPLVCYL-LILLLALALKRKRRKK 391
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
78-379 |
5.05e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 57.58 E-value: 5.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 78 LGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWVFVAEHVPARH 157
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTI--------FIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 158 VGYACGTLTSGLTAGILLGSLVATAINSFYSATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVFaelqqrkalaeev 237
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 238 plkaVVRDHRGAVLVSMLLTWVLSAA-IVVVILMTPTVLQSVyGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLT 316
Cdd:cd17359 190 ----LVSKGKPILIIGIGLAIFQQFVgINVIFYYGPEIFQNA-GFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPL 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9951692 317 FVAGSVL----LALVSWSFYGNLKAHPDWLFPLYALT---GFFVGIVGAVPYVMVNA-FPPVVRFSGLSFS 379
Cdd:cd17359 265 LLIGSIGmaisLLLIGTAFYFAPGSQASGIVALVLILlfvAFFAMSWGPVTWVLLSEiFPNRIRGLAMGIA 335
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
82-399 |
5.55e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 57.59 E-value: 5.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 82 IMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAiGGEVPGAWVFVAEHVPARHVGYA 161
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLP--------VLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 162 CGTLTSGLTAGILLGSLVATAInsfysateVQDYAWRIPFLLGGVFGLFSVYLrrwlhetpvfaelqqrkalaeeVPLKA 241
Cdd:cd17504 121 QGILSATFGIGAGIGLPLGGWI--------VQHLGWRWIFWTAAPVAVLLAAL----------------------VPLID 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 242 VVRDHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQS----VYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTF 317
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLptptGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 318 VAGSVLLAlVSWSFYGNLKAHPDWLFPLYALTGFFVG-IVGAVPYVMVNAFPPvVRFSGLSFSYNLAYAIFGGLTPMAVA 396
Cdd:cd17504 251 LIGLVISA-VGLLLLALLHSSLWALVVALLLIGIGLGlAFASLPNIVVESVPP-DRTGIATGMNTVLRTIGSAIGPAIAG 328
|
...
gi 9951692 397 LLL 399
Cdd:cd17504 329 AIL 331
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
168-397 |
9.85e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.22 E-value: 9.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 168 GLTAGILLGSLVATAINSFYSATEVQdyAWRIPFLLGGVFGLFSVYL-RRWLHETPVFAElqQRKALAEEvpLKAVVRDH 246
Cdd:COG2211 155 FAGLGGLLASVLPPPLVAAFGGDAAL--GYRLTALIFAVLGLLAFLLtFFGTKERPVPEE--EKVSLKES--LKALLKNR 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 247 R-GAVLVSMLLTWVlsaAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLA 325
Cdd:COG2211 229 PfLLLLLAYLLFFL---ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 326 LVSWSFYGNLKAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPVVR-----------FSGLSFSYNLAYAIFGGLTPMA 394
Cdd:COG2211 306 LGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrreglyFGIFTFAIKLGQALAGALAGLL 385
|
...
gi 9951692 395 VAL 397
Cdd:COG2211 386 LAL 388
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
64-422 |
1.40e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 53.35 E-value: 1.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 64 QTFGLFAAGYLarpLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVP 143
Cdd:cd17320 38 LTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 144 GAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFS-VYLRRWLHET- 221
Cdd:cd17320 107 VARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFG--------WRAIFVFLALLGLLLlLLVLLFLPETl 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 222 PVFAELQQRKALAEEvpLKAVVRDHRgaVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGC 301
Cdd:cd17320 179 PEEKRKPLLSSLLRA--YKRVLKNRR--FLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGS 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 302 IVAGRMADRYGAGLTFVAGSVLLALvswSFYGNLKAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPVVRFSG------ 375
Cdd:cd17320 255 LLNGRLVRRFGPRRLLRLGLLLLLA---AALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPhvagta 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 9951692 376 ---LSFSYNLAYAIFGGLtpMAVALLLKQSPMGPAYYVVTLCLVGFLVGL 422
Cdd:cd17320 332 salLGFLQFLIGALAGAL--VGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
20-222 |
3.97e-07 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 52.04 E-value: 3.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 20 YKTLSLSALGGALEFYDFIIFVFFATVVGKLFFPADMPewLRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMFTLS 99
Cdd:TIGR00887 15 FRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGP--LPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGME 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 100 IFMMAVPTLIMGLLPTYAQIGIWAplALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVG---------YACGTLTSGLT 170
Cdd:TIGR00887 93 LIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGammaavfamQGFGILAGAIV 170
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 9951692 171 AGILLGSLVAT--AINSFYSATEVQ----DYAWRIPFLLGGVFGLFSVYLRRWLHETP 222
Cdd:TIGR00887 171 ALIVLAGFKHSleAAADEASCTGSCvpavDYMWRILIGFGAVPALLALYFRLTIPETP 228
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
59-236 |
7.20e-07 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 51.17 E-value: 7.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 59 WLRQLqTFGLFAAGYLarpLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAI 138
Cdd:TIGR00898 127 WKVDL-TQSCFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYT--------VFLVFRLLVGMGI 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 139 GGEVPGAWVFVAEHVPARHVGYaCGTL-TSGLTAGILLGSLVATAINSfysatevqdyaWRIPFLLGGV-FGLFSVYLrR 216
Cdd:TIGR00898 195 GGIWVQAVVLNTEFLPKKQRAI-VGTLiQVFFSLGLVLLPLVAYFIPD-----------WRWLQLAVSLpTFLFFLLS-W 261
|
170 180
....*....|....*....|
gi 9951692 217 WLHETPVFAELQQRKALAEE 236
Cdd:TIGR00898 262 FVPESPRWLISQGRIEEALK 281
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-425 |
1.05e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.29 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 69 FAAGYLARPLGGVIMahfgDLLGRKRMFTLSIFMMAVPTLIMGLLPTyaqigiwaPLALLLLRVIQGAAIGGEVPGAWVF 148
Cdd:cd17489 41 TLAALLARPFAGRLL----DRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 149 VAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSAtevqdyawRIPFLLGGVFGLFSVYLRRWLHETPvfaelq 228
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGF--------AVLFIVAAVLALLALLLVFLVKDPP------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 229 QRKALAEEVPLKAVVRDHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVcltLGCIVAGRMA 308
Cdd:cd17489 175 PVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALL---LSRPFSGKLS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 309 DRYGAGLTFVAGSVLLALVSWSFYgnlKAHPDWLFPLYA-LTGFFVGIV-GAVPYVMVNAFPPVVRFSGLSfSYNLAYAI 386
Cdd:cd17489 252 DRKGPKTVIIPGLLLLALGLLLLS---FAGSPWMLLLAAvLYGLGFGLLfPALQALAVDLVPPHRRGAANG-TFFIFFDL 327
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 9951692 387 FGGLTPMAVALLLKQSPMGPAYYVVTLC-LVGFLVGLYLL 425
Cdd:cd17489 328 GIGLGGLLLGLVAELFGYRAMFLLAAVVvLLALVLYIFLL 367
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
69-327 |
1.61e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.96 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 69 FAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWVF 148
Cdd:PRK11551 56 FSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIAL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 149 VAEHVPARHVGYACGTLTSGLTAGILLGSLVATAinsfysatEVQDYAWRIPFLLGGVFGLFSV-YLRRWLHETPVFAEL 227
Cdd:PRK11551 128 TSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVL--------AAGDAAWRHIFYVGGVGPLLLVpLLMRWLPESRAFAQA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 228 QQRKAlAEEVPLKAVVRDHRGAvlvSMLLTWV--LSAAIVVVILMT--PTVLQSvYGFDAATALKANSLAIVCLTLGCIV 303
Cdd:PRK11551 200 AGAGK-QRAPVLRALFGEGRAT---ATLLLWIsyFFTLIVLYFLLNwlPSLLVG-QGLSRSQAGLVQIAFNIGGALGSLL 274
|
250 260
....*....|....*....|....*.
gi 9951692 304 AGRMADRYGAGLT--FVAGSVLLALV 327
Cdd:PRK11551 275 IGALMDRLRPRRVvlLIYAGILASLA 300
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
69-403 |
1.65e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.96 E-value: 1.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 69 FAAGYLARPLGGvimaHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAaIGGEVPGAWVF 148
Cdd:cd17391 46 FLVSAIFSPIWG----RLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQ--------LLILRLLQGV-FSGYVPNATAL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 149 VAEHVPARHVGYACGTLTSGLTAGILLGSLVATAInsfysateVQDYAWRIPFLLGGVFgLFSVYLRrwlheTPVFA-EL 227
Cdd:cd17391 113 IASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFL--------ADLFGIRNVFFITGGL-LFLAFLL-----TLFFVkED 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 228 QQRKALAEEVPLKAVVRD--HRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKAN---SLAIVCLTLGCI 302
Cdd:cd17391 179 FKPVEKKKMVSTKEVWNSvpNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGlvfSATGVSSLLSAP 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 303 VAGRMADRYGAGLTFVAGSVLLALVswsfygnlkahpdwlfplyaltgffvgivgavpYVMVNAFPPVVRFSGLSFSYNL 382
Cdd:cd17391 259 RLGKLGDRIGHHRILLGALLASALL---------------------------------YIPQAFVQTPWQLGILRFLLGL 305
|
330 340
....*....|....*....|.
gi 9951692 383 AyaiFGGLTPMAVALLLKQSP 403
Cdd:cd17391 306 A---TGGLLPAINSLLAKITP 323
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
79-218 |
1.88e-06 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 49.58 E-value: 1.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 79 GGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQIGIWAplALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHV 158
Cdd:cd17364 55 GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRR 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9951692 159 GYACGTLTSGLTAGILLGSLVATAINSFYSATEVQ------DYAWRIPFLLGGVFGLFSVYLRRWL 218
Cdd:cd17364 133 GALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAgtyhhaDLVWRIVLGLGAIPALSVLYFRKHL 198
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
159-426 |
5.25e-06 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 48.61 E-value: 5.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 159 GYACGTLTSGLTAGILLGSLVATAINSFYSATEvqdyAWRIPFLLGGV-FGLFSVYLRRWLHETPVFAELQQRKALAEEV 237
Cdd:COG2270 149 GWALGYLGGVLLLLINLALFLKPEAFGLPDAGE----AVRISFLLTALwWLLFALPLFLFLPERPRPGPAPPRGAVRAGF 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 238 P-LKAVVRD--HRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKAnsLAIVCLT--LGCIVAGRMADRYG 312
Cdd:COG2270 225 ReLRRTLRElrRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVF--GLLVQIVaaLGALLFGRLDDRIG 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 313 AGLTFVAGSVLLALVSWSFYGnlkAHPDWLFPLYALT-GFFVGIVGAVPYVMVNAFPPVVRfSGLSFSYnlaYAIFGGLT 391
Cdd:COG2270 303 PKRVILVSLVIWIVVCLAAYF---LTTALAFWILGLLiGLVMGGIQALSRSLLARLIPPGR-EAEFFGL---YALSGKAA 375
|
250 260 270
....*....|....*....|....*....|....*....
gi 9951692 392 ----PMAVALLLKQSpmGPAYYVVTLCLVGFLVGLYLLA 426
Cdd:COG2270 376 sflgPLLFGLVTQLT--GSQRLGILSLIVFFVIGLVLLL 412
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
68-427 |
5.72e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 5.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 68 LFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQIGIWAPLALLLLRVIQGAAIGgevPGAWV 147
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFG---PARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 148 FVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSAtevqdyawRIPFLLGGVFGLFSVYLRRWLHETPVFAEL 227
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP--------GGAFAINALSFLLSALLLLFIRRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 228 QQRKALAEEVPLKAVVRDHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRM 307
Cdd:cd06173 188 ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 308 ADRYGAGLTFVAGSVLLALVSWSFYgnLKAHPDWLFPLYALTGFFVGIVGAVPYVMVNAFPPVVRFSGLSFSYNLAYAIF 387
Cdd:cd06173 268 SKRRRRGRLLLIGALLLGLALLVLG--LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGA 345
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 9951692 388 GGLTPMAVALLLkqSPMGPAYYVVTLCLVGFLVGLYLLAQ 427
Cdd:cd06173 346 MPLGALLAGLLA--DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
86-380 |
7.22e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 47.56 E-value: 7.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 86 FGDLLGRKRMFTLSIFMMAVPTLIMGLLPTyaqigiwaPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTL 165
Cdd:cd17502 53 LSDLFGRKWVLLIAIVIFELGSLLCGLAPN--------MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 166 TSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFSVYLRRwlhetpvfaelqqrkalaeevplkavvrd 245
Cdd:cd17502 125 GAVFGIASVAGPLIGGAFTDHLS--------WRWCFYINLPIGGLALALLR----------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 246 hrgAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLA 325
Cdd:cd17502 168 ---TILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILM 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 9951692 326 LVS--WSFYGNLKAHPDWLFPLYALTGFFVGIVGAVPYVMV-NAFPPVVRFSGLSFSY 380
Cdd:cd17502 245 SVGagLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVqNAVPPADVGVATATNT 302
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
78-424 |
7.29e-06 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 48.03 E-value: 7.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 78 LGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLlptyaqiGIWAPLALLLL--RVIQGAAIGGEVPGAWVFVAEHVPA 155
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-------SKSAKSPELLIfgRFLVGIACGLSTGFVPMYLQEISPS 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 156 RHVGyACGTLTS-GLTAGILLGSLVATainSFYSATEvqdYAWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQ----- 229
Cdd:cd17357 137 ELRG-ALGSLTQiGVTLGILLGQVFGL---PSVLGTE---TLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKgdeee 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 230 -RKAL--------------------------AEEVPLKAVVRD---HRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVy 279
Cdd:cd17357 210 aEKSLkflrgieddvdqeleeikkeseqmgdQKQVSLMQLLRDpslRLPLLLVLVVSASQQFSGINAIFFYSTFIFENA- 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 280 GFDAATALKANSLAIVCLTLGCIVAGRMADRYGAG--LTFVAGSVLLALVSWSFYGNLKAHPDWL-FPLYALT---GFFV 353
Cdd:cd17357 289 GFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRplLLISLSVCAVALLLMSVFLFLSEQNSWMsYGCIVAIflfIFFF 368
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9951692 354 GI-VGAVPY-VMVNAFPPVVRFSGLSFSYnLAYAIFGGLTPMAVALLlkQSPMGPAYY---VVTLCLVGFLVGLYL 424
Cdd:cd17357 369 AIgLGPIPWfIGAELFPQAPRSAAQSLGS-SVNWTSNFIVGMAFPPL--QSIGGGFVFiifAIPCALFLLYLYRYL 441
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
78-379 |
1.27e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 47.18 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 78 LGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWVFVAEHVPARH 157
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 158 VgyacGTLTSGLTAGILLGSLVATAINSFYSATevQDYAWRIPFLLGGVFGLFSVYLRRWLHETPvfaelqqrkalaeev 237
Cdd:cd17315 121 R----GALGTLNQLMITFGILLAYLLGLALSLS--PPGWWRLMFALAAVPALLQLLLMFFLPESR--------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 238 plkavvrdhrgAVLVSMLLTWVLSAA-IVVVILMTPTVLQSVYGFDAATALKanslAIVCLT--LGCIVAGRMADRYG-- 312
Cdd:cd17315 180 -----------ALLVGVGLQLLQQLTgINAVMYYAPTIFKSAGGGTASILAS----IIVGVVnlLATLVAIRLVDKVGrr 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 9951692 313 --AGLTFVAGSVLLALVSWSFYGNLKAHPDWLFPLYALTGFFVGI---VGAVPYVMVNA-FPPVVRFSGLSFS 379
Cdd:cd17315 245 plLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFamgAGPVPWLLLSEiFPLRIRGKGMAIA 317
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
68-178 |
1.90e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.84 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 68 LFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLlptyAQiGIWAplaLLLLRVIQGAaIGGEVPGAWV 147
Cdd:PRK09874 59 VFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGL----AQ-NIWQ---FLILRALLGL-LGGFVPNANA 129
|
90 100 110
....*....|....*....|....*....|.
gi 9951692 148 FVAEHVPARHVGYACGTLTSGLTAGILLGSL 178
Cdd:PRK09874 130 LIATQVPRNKSGWALGTLSTGGVSGALLGPL 160
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
77-425 |
2.48e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.02 E-value: 2.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 77 PLGGVIMAHFGdllgRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGAWVFVAEHVPAR 156
Cdd:cd17474 52 PVAGVLADRFG----RKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAGLGPLALTLIGDLFEGG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 157 HVGYACGTLTSGLTAGILLGSLVATAINSFysatevqdyAWRIPFLLGGVFGLFSVYLRRWLHEtPVFAELQQRKALAEE 236
Cdd:cd17474 120 ERAKAMGLYEAALGLGIAVGPLLGGLLAAI---------SWRYPFFLLAALIPVAFLAILFLLP-EPKEKAKSSSATKLR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 237 VPLKAVvrdHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGR-MADRYGAGL 315
Cdd:cd17474 190 DLKKAL---RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 316 TFVAGSVLLALVSWSFygNLKAHPDWLFPLYALTGFFVGIV-GAVPYVMVNAFPPVVRFSGLSFsYNLAYAIFGGLTPMA 394
Cdd:cd17474 267 ILVIGLLLYALSLLLL--GFVPSLALLLIAIVLFGLGLGLNlPLLTTLVTELAPEEERGTASSL-YNFVRFLGQAVGPLL 343
|
330 340 350
....*....|....*....|....*....|.
gi 9951692 395 VALLLKQSPMGPAYYVVTLCLVGFLVGLYLL 425
Cdd:cd17474 344 FGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
82-354 |
2.78e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.01 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 82 IMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGAWVFVAeHVPARHVGYA 161
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW--------LLLLLVALAGIGSAAFHPEGARLAS-QAAGGRRGLA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 162 CGTLTSGLTAGILLGSLVATAINSFYSAtevqdYAWRIPFLLGGVFGLFSVYLRRWLHetpvfaeLQQRKALAEEVPLKA 241
Cdd:cd17478 121 MSIFSVGGNLGFALGPLIAAALVALFGG-----LGLLILLIIPGLAVALLLLRLRPLK-------KPEAKKAAAKSSARS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 242 VVRDHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSvYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGS 321
Cdd:cd17478 189 TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASL 267
|
250 260 270
....*....|....*....|....*....|...
gi 9951692 322 VLLALVSWSFygnLKAHPDWLFPLYALTGFFVG 354
Cdd:cd17478 268 LLAAPFLLLF---LLTPGIWSYILLVLAGFLLF 297
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
78-425 |
1.29e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 78 LGGVIMAHFGDLLGRKRMFTLSIFMMAvptlIMGLLPTYAQigiwAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVP--- 154
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYG----IGGVAGLFLD----SLYALLASRALLGIGVAGIMTLATALIGDYFEgee 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 155 -ARHVGYACGTLTSGLTAGILLGSLVAtainsfysatevqDYAWRIPFLLGGVFGLFSVYLRRWLHETpvfaelQQRKAL 233
Cdd:cd17473 122 rAKMLGLQSAAMSLGGVVFLLLGGALA-------------EIGWRAPFLVYLLALPVLILVLLFLPEP------ARKSKS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 234 AEEVPLKAVVRDHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATAlkanSLAIVCLTLGCIVAG----RMAD 309
Cdd:cd17473 183 AASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI----GLALAIASLAGAIGAllfgRLKR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 310 RYGAGLTFVAGSVLLALvswSFYG-NLKAHPDWLFPLYALTGFFVGIVgaVPYVMVNAF---PPVVRFSGLSFsynLAYA 385
Cdd:cd17473 259 RLGKRRLLAIGFALMAL---GFLLlALASGLWVVLLGAILAGLGFGLL--LPTLNSWAMslvPPELRGRAMGI---VTSA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 9951692 386 IFGG--LTPMAVALLLKQSPMGPAYYVVT--LCLVGFLVGLYLL 425
Cdd:cd17473 331 FFLGqfLSPLVLGPLVNLTGGLSGAFLILgvLALVLAIVLLLLR 374
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
67-379 |
1.83e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 43.50 E-value: 1.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 67 GLFAAGYLARPLGGVIMAHF-GDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGA 145
Cdd:cd17362 42 GLVVSGSLLGALLGSLVAGAlIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 146 WVFVAEHVPARHVgyacGTLTSGLTAGILLGSLVATAINSFYSATEvqdYAWRIPFLLGGVFGLFSVYLRRWLHETPVFa 225
Cdd:cd17362 114 PVYIAETSPSHIR----GLLVSLKELFIVLGILLGYVSGYAFADVV---GGWRYMYGLAAPPALLLGIGMWFLPPSPRW- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 226 ELQQRKALaeevplkavvrdhrgaVLVSMLLTWVLSAAIVVVILMTPTVLQSVyGFDAATALKANSLAI-VCLTLGCIVA 304
Cdd:cd17362 186 QGNYRKPL----------------IIGLGLVLFQQITGQPSVLYYAATIFKSA-GFSAASDATLVSVGLgVFKLLMTIVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 305 GRMADRYGAG---LTFVAGSVLLALVSWSFYGNLKAHPDW-----LFPLYALTGFFVGIVGAVPYVMVNA-FPPVVRFSG 375
Cdd:cd17362 249 VLLVDKLGRRpllLGGVSGMVVSLFLLAAYNLFVQMGPAGlawlsLVALLLYVGAYQISFGPISWLMVSEiFPLRVRGRA 328
|
....
gi 9951692 376 LSFS 379
Cdd:cd17362 329 IALA 332
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
80-327 |
2.31e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 43.38 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 80 GVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVG 159
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--------LLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 160 ------YACGTLTSGLtaGILLGSLVATAINSfysatevqdyaWRIPFLLGGVFGLFSVYLRRWLHETPVFAELQQRKAL 233
Cdd:cd17328 123 ralgvfYFAIPLGSGL--GYVVGGLVAQATGG-----------WRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 234 AEEVP-----LKAVVRDHrgAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYG----FDAATALKANSLAIVCLTLGCIVA 304
Cdd:cd17328 190 KSTATsfladLKALAKNP--SFILSTLGFTAVSFVTGALAFWAPTFFLRAFGvgdlSSADVGLIFGAITCIAGVLGVLLG 267
|
250 260
....*....|....*....|....*..
gi 9951692 305 GRMADRYGA----GLTFVAGSVLLALV 327
Cdd:cd17328 268 GILADRLRRktprADPLVCAVGLLAAA 294
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
73-224 |
2.82e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 42.99 E-value: 2.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 73 YLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGAWVFVAEH 152
Cdd:cd17438 44 YLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEF 115
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9951692 153 VP----ARHVGYACGT-LTSGLTAGILLGSLVATAINSFYSATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVF 224
Cdd:cd17438 116 LArekrGEHLSWLCMFwMIGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIICALPCIASIIALKFMPESPRF 192
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
78-354 |
7.42e-04 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 41.49 E-value: 7.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 78 LGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQIGIwaplalllLRVIQGAAIGGEVPGAWVFVAEHVPARH 157
Cdd:cd17312 53 VGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAV--------LWGLNGLFQSMGWPPCVKLLGNWFSKKE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 158 VGYACGTLTSGLTAGILLGSLVATAInsfysateVQDYAWRIPFLLGGVFGL-FSVYLRRWLHETPVfaelqqrkalaee 236
Cdd:cd17312 125 RGTVYGIWSTSHNFGGILAPILAASL--------ASYYGWRAAFLVPGIVGLvVAIILFFFLRDSPP------------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 237 vplkavvrdhrgavlvsmlLTWVLSAAIVVVILM-------TPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMAD 309
Cdd:cd17312 184 -------------------YVWVLSLAYAFVYIVryacldwGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSD 244
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 9951692 310 RYGAGLTFVAGSVLLALVSWSFYGNLKAHPDWLFP--LYALTGFFVG 354
Cdd:cd17312 245 KLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSivLLFLIGFFVG 291
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
78-356 |
1.55e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.63 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 78 LGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGAWVFVAEHVPaRH 157
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVA--------LLLAGTALIGAGIAVGNVLLPGLIKRWFP-DR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 158 VGYACGTLTSGLTAGILLGSLVATAInsfysateVQDYAWRIPFLLGGVFGLFSVYLrrWLhetPVFAELQQRKALAEEV 237
Cdd:COG2807 139 VGLMTGLYTAAMGLGAALAAGLTVPL--------AAALGWRGALAVWALLALLALLL--WL---PLLRRRPAAAAAAPAA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 238 PLKAVVRDHRGAVLVSMLLTWVLSAAIVVVILMtPTVLQSvYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTF 317
Cdd:COG2807 206 ASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWL-PPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL 283
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 9951692 318 VAGSVLLALVSWSFygnLKAHPDWLFPLYA-LTGFFVGIV 356
Cdd:COG2807 284 LLLLGLLGLAGLLG---LLLAPGSLPWLWAvLLGLGQGGL 320
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
66-309 |
1.68e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 40.29 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 66 FGLFAAGYLARPLGGvimAHFGDLLGRKRMFTLSIFMMAVPTLimgLLPTYAQIGIWAplaLLLLRVIQGAAIGGEVPGA 145
Cdd:cd17318 62 LSSFFYGYILTQIPG---GYLAEKYGAKRVLGYSILITALLTL---LTPLAARGGYGA---LIVLRILQGLAQGVTFPAM 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 146 WVFVAEHVPARHVGYacgtLTSGLTAGILLGSLVATAINSFYSATevqdYAWRIPFLLGGVFGLFSVYLRRWLhetpvfa 225
Cdd:cd17318 133 HALWAKWAPPLERSR----LTSIAYSGSQFGTVIAMPLSGFLCES----LGWPSIFYIFGGLGLLWCLLWFFL------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 226 elqqrkalaeEVPLKAVVRDHRGAV-LVSMLLTWvlsaaivvvilmTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVA 304
Cdd:cd17318 198 ----------VLPVWAIVVAHFGHNwGFYTLLTE------------LPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVG 255
|
....*
gi 9951692 305 GRMAD 309
Cdd:cd17318 256 GYLAD 260
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
37-425 |
5.31e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 37 FIIFVFFATVVGKLFFPADMPEWLRQLQTFGLFAAGYL--ARPLGGVIMAHFG----DLLGRKRMFTLSIFMMAVPTLIM 110
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVlaLSAVAGIVASLIGgrlaDRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 111 GLLptyaqigiWAPLALLLLRVIQGAAIGGEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAInsfysat 190
Cdd:cd17329 83 GFA--------HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 191 evQDYAWRIPFLLGGV-FGLFSVYLRRWLHETpvFAELQQRKALAEEVPLKAVVRDHR-GAVLVSMLLTWVLSAAIVVVI 268
Cdd:cd17329 148 --LLYSFRLLFLAAAVlFLLAALVLLFLLPET--RPKRRAAEKTEILRGYKIVLRDRAfLLFLLASFLISLIYFQLESTL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 269 LMTPTVLQSVYGFDAATALKANSLAIVCLTLgciVAGRMADRYGAGLTFVAGSVLLAlVSWSFYGNLKAHPDWLFPLYAL 348
Cdd:cd17329 224 PVYVVEILGLGESLLGLLLALNALLIVLLQF---PVARLVERFRLRKILMIGILLFA-IGFAVLAFANTLAVLILAMIVL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9951692 349 TgffVGIVGAVPYVM--VNAFPPVVRFSGLSFSYNLAYAIFGGLTPMAVALLLKQSPMGPAYYVVTLCLVGFLVGLYLL 425
Cdd:cd17329 300 T---LGEMLVFPAVQtlVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
247-436 |
5.43e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.71 E-value: 5.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 247 RGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLTLGCIVAGRMADRYGAGLTFVAGSVLLAL 326
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 327 VSWSFYGnlkAHPDWLFPLYA-LTGFFVGIVGAVPYVMVNA-FPPVVRFSGLSFsYNLAYAIFGGLTPMAVALLLKQSPM 404
Cdd:COG2223 83 GLLLLAL---AVSYWLLLLLGlLLGIGGGGSFAVGIALVSKwFPPDRRGLALGL-AAGGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190
....*....|....*....|....*....|..
gi 9951692 405 GPAYYVVTLCLVGFLVGLYLLAQKKPAGEAVS 436
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAA 190
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
65-360 |
5.51e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 38.79 E-value: 5.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 65 TFGLFAAGyLARPLGGVIMAHFGDllgrKRMFTLSIFMMAVPTLIMGLLPTYAQIgiwaplaLLLLRVIQGAAIGGEVPG 144
Cdd:cd17355 45 TVGLLAFG-LAQPFVGRLLDRFGP----RRVMLLGLLLLAAGLVLLALATSLWQL-------YLLWGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 145 AWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFSV-----YLRRWLH 219
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG--------WRTALLVLALLALLVLvpvllLLRRRPA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 220 ETPVFAELQQRKALAEEVpLKAVVRDHRGAVLVSMLLTWVLSAAIVVVILMTPTVLQsvyGFDAATALKANSLAIVCLTL 299
Cdd:cd17355 185 DLALRAYDDASPASPGST-LKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR---GISPAAAAVALALIGLFNIV 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9951692 300 GCIVAGRMADRYGAGLTfVAGSVLLALVSWSFYGNLKAHPDWLFPLYALTGFFVGIVGAVP 360
Cdd:cd17355 261 GRLLSGWLGDRYSPRRL-LAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLT 320
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
68-185 |
5.97e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.72 E-value: 5.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 68 LFAAGYLarpLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGAWV 147
Cdd:cd17317 33 IFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFV 101
|
90 100 110
....*....|....*....|....*....|....*...
gi 9951692 148 FVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINS 185
Cdd:cd17317 102 LGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD 139
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
60-353 |
6.58e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 38.37 E-value: 6.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 60 LRQLQTFGLFAAGYLARPLGGVIMAHFGDLLGRKRMftLSIFMMAVPTLIMGLlptYAQIGIWAPLALLLLrviQGAAIG 139
Cdd:cd17475 28 LSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRV--LAVGLLLMGAAALLM---ALVGSYPVLLVLLFL---VGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 140 GEVPGAWVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFS-VYLRRWL 218
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG--------WRAAFVVAGLVSILAaVLFWLFY 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 219 HETPVFAeLQQRKALAEEVPLKAVVRDhrGAVLVSMLLTWVLSAAIVVVILMTPTVLQSVYGFDAATALKANSLAIVCLT 298
Cdd:cd17475 172 REPPAAS-AATESASTLLRSLKEVLRN--RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGA 248
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9951692 299 LGCIVAGRMADRYGAG-----LTFVAGSVLLALVSWSFygNLKAHPDWL-FPLYALTGFFV 353
Cdd:cd17475 249 LGRIGLGRVSDRVFGGrrrpvLVITAAIAAAALLVLSL--LSPGTPLWLlVLLLILLGLFA 307
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
73-224 |
9.15e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 38.42 E-value: 9.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 73 YLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAqigiwaplALLLLRVIQGAAIGGEVPGAWVFVAEH 152
Cdd:TIGR01299 212 YLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYG--------FFLFCRLLSGFGIGGAIPIVFSYFAEF 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9951692 153 VP----ARHVGYACGT-LTSGLTAGILLGSLVATAINSFYSATEVQDYAWRIPFLLGGVFGLFSVYLRRWLHETPVF 224
Cdd:TIGR01299 284 LAqekrGEHLSWLCMFwMIGGIYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRF 360
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
68-353 |
9.36e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.13 E-value: 9.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 68 LFAAGYLARPLGGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGAWV 147
Cdd:TIGR00881 35 LLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWV--------MAALWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 148 FVAEHVPARHVGYACGTLTSGLT-AGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGL-FSVYLRRWLHETPV-- 223
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNvGGGLLPPLVLFGIAELYS--------WHWVFIVPGIIAIiVSLICFLLLRDSPQsc 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 224 -----------FAELQQRKALAEEVPLKAVVRdhrgAVLVSMLLtWVLSAAIVVVILM-------TPTVLQSVYGFDAAT 285
Cdd:TIGR00881 179 glppaeempneEPDGDAEKKEEELTKKQIFLQ----YVLLNKVL-WYISLGYVFVYVVrtgildwSPLYLTQEKGFSKEK 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9951692 286 ALKANSLAIVCLTLGCIVAGRMAD------RYGAGLTFVAGSVLLALVSWSFYGnlkAHPDWLFPLYALTGFFV 353
Cdd:TIGR00881 254 ASWAFTLYELGGLVGTLLAGWLSDklfngrRGPLAVFFMALIIVSLLVYWLNPA---ANPLMDLICLFALGFLV 324
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
67-221 |
9.66e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 36.47 E-value: 9.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9951692 67 GLFAAGYLARPL-GGVIMAHFGDLLGRKRMFTLSIFMMAVPTLIMGLLPTYAQigiwaplaLLLLRVIQGAAIGGEVPGA 145
Cdd:TIGR00880 1 GLLLAGYALGQLiYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITV--------LIIARFLQGFGAAFALVAG 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9951692 146 WVFVAEHVPARHVGYACGTLTSGLTAGILLGSLVATAINSFYSatevqdyaWRIPFLLGGVFGLFS-VYLRRWLHET 221
Cdd:TIGR00880 73 AALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLG--------WRAPFLFLAILALAAfILLAFLLPET 141
|
|
| |
