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Conserved domains on  [gi|10799281|gb|AAG21886|]
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EP2I, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sperm_Ag_HE2 super family cl05073
Sperm antigen HE2; This family consists of several variants of the human and chimpanzee sperm ...
 1-51 1.10e-22

Sperm antigen HE2; This family consists of several variants of the human and chimpanzee sperm antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a family of androgen-dependent, epididymis-specific secretory proteins.The EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages. The translated putative protein variants differ significantly from each other. Some of these putative proteins have similarity to beta-defensins, a family of antimicrobial peptides.


The actual alignment was detected with superfamily member pfam05324:

Pssm-ID: 461622  Cd Length: 70  Bit Score: 81.08  E-value: 1.10e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 10799281    1 SSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLLPPRTPPYQE 51
Cdd:pfam05324 18 LSRARHVNHQDTEGPRELGEESPGQGTNGSQLLHHQVKRYLLPPRTPPYPE 68
 
Name Accession Description Interval E-value
Sperm_Ag_HE2 pfam05324
Sperm antigen HE2; This family consists of several variants of the human and chimpanzee sperm ...
 1-51 1.10e-22

Sperm antigen HE2; This family consists of several variants of the human and chimpanzee sperm antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a family of androgen-dependent, epididymis-specific secretory proteins.The EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages. The translated putative protein variants differ significantly from each other. Some of these putative proteins have similarity to beta-defensins, a family of antimicrobial peptides.


Pssm-ID: 461622  Cd Length: 70  Bit Score: 81.08  E-value: 1.10e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 10799281    1 SSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLLPPRTPPYQE 51
Cdd:pfam05324 18 LSRARHVNHQDTEGPRELGEESPGQGTNGSQLLHHQVKRYLLPPRTPPYPE 68
 
Name Accession Description Interval E-value
Sperm_Ag_HE2 pfam05324
Sperm antigen HE2; This family consists of several variants of the human and chimpanzee sperm ...
 1-51 1.10e-22

Sperm antigen HE2; This family consists of several variants of the human and chimpanzee sperm antigen proteins (HE2 and EP2 respectively). The EP2 gene codes for a family of androgen-dependent, epididymis-specific secretory proteins.The EP2 gene uses alternative promoters and differential splicing to produce a family of variant messages. The translated putative protein variants differ significantly from each other. Some of these putative proteins have similarity to beta-defensins, a family of antimicrobial peptides.


Pssm-ID: 461622  Cd Length: 70  Bit Score: 81.08  E-value: 1.10e-22
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 10799281    1 SSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLLPPRTPPYQE 51
Cdd:pfam05324 18 LSRARHVNHQDTEGPRELGEESPGQGTNGSQLLHHQVKRYLLPPRTPPYPE 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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