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Conserved domains on  [gi|23092706|gb|AAG22219|]
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uncharacterized protein Dmel_CG1233, isoform B [Drosophila melanogaster]

Protein Classification

zinc finger family protein( domain architecture ID 706824)

zinc finger family protein may be involved in transcriptional regulation; similar to Schizosaccharomyces pombe E3 ubiquitin-protein ligase hel2, which that plays a key role in the ribosome quality control (RQC), and Homo sapiens histone H4 transcription factor

Gene Ontology:  GO:0008270
PubMed:  11179890

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5236 super family cl28715
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
814-1043 2.12e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5236:

Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 45.40  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23092706  814 HGRCHNGSLSSNQPVVCPECKSSNFSNWNCLHTHlwRTHQIDMELYSCQLCSFKTPiYSRLVNTHAKIhseernykCEQC 893
Cdd:COG5236   19 QGPQNNTKPHNDRKNFRRKQKKNNLSAEPNLTTS--SADDTDEENMNCQICAGSTT-YSARYPCGHQI--------CHAC 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23092706  894 GKgfkntkqlkNHRRLHRTQGLGMGKQSNEQIsvgpegnpVVMHRCEDCGAAFKQKKTLREHL--------CKERNEQL- 964
Cdd:COG5236   88 AV---------RLRALYMQKGCPLCRTETEAV--------VFTASSPADITDRRQWKGREEKVgifyegedVRDEMEDLl 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23092706  965 --ECPE--CQRRFGSKSSLRLHLRShqEHKRFRCD---------TCDHETSDHNAYRRHLATHKESKRYS----CPHCDF 1027
Cdd:COG5236  151 sfKCPKskCHRRCGSLKELKKHYKA--QHGFVLCSecignkkdfWNEIRLFRSSTLRDHKNGGLEEEGFKghplCIFCKI 228

                        250
                 ....*....|....*.
gi 23092706 1028 RAIQSTAFRIHLQTRH 1043
Cdd:COG5236  229 YFYDDDELRRHCRLRH 244
 
Name Accession Description Interval E-value
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
814-1043 2.12e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 45.40  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23092706  814 HGRCHNGSLSSNQPVVCPECKSSNFSNWNCLHTHlwRTHQIDMELYSCQLCSFKTPiYSRLVNTHAKIhseernykCEQC 893
Cdd:COG5236   19 QGPQNNTKPHNDRKNFRRKQKKNNLSAEPNLTTS--SADDTDEENMNCQICAGSTT-YSARYPCGHQI--------CHAC 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23092706  894 GKgfkntkqlkNHRRLHRTQGLGMGKQSNEQIsvgpegnpVVMHRCEDCGAAFKQKKTLREHL--------CKERNEQL- 964
Cdd:COG5236   88 AV---------RLRALYMQKGCPLCRTETEAV--------VFTASSPADITDRRQWKGREEKVgifyegedVRDEMEDLl 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23092706  965 --ECPE--CQRRFGSKSSLRLHLRShqEHKRFRCD---------TCDHETSDHNAYRRHLATHKESKRYS----CPHCDF 1027
Cdd:COG5236  151 sfKCPKskCHRRCGSLKELKKHYKA--QHGFVLCSecignkkdfWNEIRLFRSSTLRDHKNGGLEEEGFKghplCIFCKI 228

                        250
                 ....*....|....*.
gi 23092706 1028 RAIQSTAFRIHLQTRH 1043
Cdd:COG5236  229 YFYDDDELRRHCRLRH 244
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 888-910 3.14e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 3.14e-04
                           10        20
                   ....*....|....*....|...
gi 23092706    888 YKCEQCGKGFKNTKQLKNHRRLH 910
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
814-1043 2.12e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 45.40  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23092706  814 HGRCHNGSLSSNQPVVCPECKSSNFSNWNCLHTHlwRTHQIDMELYSCQLCSFKTPiYSRLVNTHAKIhseernykCEQC 893
Cdd:COG5236   19 QGPQNNTKPHNDRKNFRRKQKKNNLSAEPNLTTS--SADDTDEENMNCQICAGSTT-YSARYPCGHQI--------CHAC 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23092706  894 GKgfkntkqlkNHRRLHRTQGLGMGKQSNEQIsvgpegnpVVMHRCEDCGAAFKQKKTLREHL--------CKERNEQL- 964
Cdd:COG5236   88 AV---------RLRALYMQKGCPLCRTETEAV--------VFTASSPADITDRRQWKGREEKVgifyegedVRDEMEDLl 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23092706  965 --ECPE--CQRRFGSKSSLRLHLRShqEHKRFRCD---------TCDHETSDHNAYRRHLATHKESKRYS----CPHCDF 1027
Cdd:COG5236  151 sfKCPKskCHRRCGSLKELKKHYKA--QHGFVLCSecignkkdfWNEIRLFRSSTLRDHKNGGLEEEGFKghplCIFCKI 228

                        250
                 ....*....|....*.
gi 23092706 1028 RAIQSTAFRIHLQTRH 1043
Cdd:COG5236  229 YFYDDDELRRHCRLRH 244
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 888-910 3.14e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 3.14e-04
                           10        20
                   ....*....|....*....|...
gi 23092706    888 YKCEQCGKGFKNTKQLKNHRRLH 910
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
878-899 5.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 5.43e-03
                           10        20
                   ....*....|....*....|..
gi 23092706    878 HAKIHSEERNYKCEQCGKGFKN 899
Cdd:pfam13465    5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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