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Conserved domains on  [gi|12002221|gb|AAG43244|]
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truncated epidermal growth factor receptor, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GF_recep_IV super family cl37890
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 1-53 9.19e-22

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


The actual alignment was detected with superfamily member pfam14843:

Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 83.96  E-value: 9.19e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 12002221     1 GPDNCIQCAHYIDGPHCVKTCPAGVMGENNtLVWKYADAGHVCHLCHPNCTYG 53
Cdd:pfam14843  71 GADNCTKCAHFRDGPHCVSSCPSGVLGEND-LIWKYADANGVCQPCHPNCTQG 122
 
Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 1-53 9.19e-22

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 83.96  E-value: 9.19e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 12002221     1 GPDNCIQCAHYIDGPHCVKTCPAGVMGENNtLVWKYADAGHVCHLCHPNCTYG 53
Cdd:pfam14843  71 GADNCTKCAHFRDGPHCVSSCPSGVLGEND-LIWKYADANGVCQPCHPNCTQG 122
 
Name Accession Description Interval E-value
GF_recep_IV pfam14843
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ...
 1-53 9.19e-22

Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030).


Pssm-ID: 464344 [Multi-domain]  Cd Length: 132  Bit Score: 83.96  E-value: 9.19e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 12002221     1 GPDNCIQCAHYIDGPHCVKTCPAGVMGENNtLVWKYADAGHVCHLCHPNCTYG 53
Cdd:pfam14843  71 GADNCTKCAHFRDGPHCVSSCPSGVLGEND-LIWKYADANGVCQPCHPNCTQG 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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