NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|14043147|gb|AAH07561|]
View 

Proliferation-associated 2G4, 38kDa [Homo sapiens]

Protein Classification

M24 family metallopeptidase; aminopeptidase P family protein( domain architecture ID 10794573)

M24 family metallopeptidase cleaves amido-, imido-, or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes| aminopeptidase family protein P (peptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 1-388 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


:

Pssm-ID: 273105  Cd Length: 390  Bit Score: 640.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147     1 MSGEDEQQEQ--TIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPT 78
Cdd:TIGR00495   1 MSGKDEQQEQaySLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147    79 SISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVK 158
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   159 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 238
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   239 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 318
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   319 FKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLE 388
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGETME 390
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 1-388 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 640.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147     1 MSGEDEQQEQ--TIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPT 78
Cdd:TIGR00495   1 MSGKDEQQEQaySLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147    79 SISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVK 158
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   159 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 238
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   239 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 318
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   319 FKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLE 388
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGETME 390
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 18-334 6.97e-118

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 342.00  E-value: 6.97e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  18 VTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQD 97
Cdd:cd01089   1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  98 YILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSF 177
Cdd:cd01089  81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147 178 NCTPIEGMLSHQLKQhvidgektiiqnptdqqkkdhekaefevhevyavdvLVSSGEGKAKdagqrttiykrdpskqygl 257
Cdd:cd01089 161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14043147 258 kmktsraffseverrfdampftlrafedekkarmgVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT 334
Cdd:cd01089 186 -----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLT 227
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 62-329 2.70e-20

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 92.08  E-value: 2.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   62 KIFKKEKEM------KKGIAFPTSISVNNCVCHFSPLKSDqDYILKEGDLVKIDLGVHVDGFIANVAHTFVVD-----VA 130
Cdd:PTZ00053 191 RIESKSRELieadglKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDCAFTVAFNpkydpLL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  131 QGTQ---VTGrkadvIKAAHLCAeaalRLVKPGNQNTQVTEAW-----NKVahsFNCTPIEGMLSHQLKQHVIDGEKTI- 201
Cdd:PTZ00053 270 QATKdatNTG-----IKEAGIDV----RLSDIGAAIQEVIESYeveikGKT---YPIKSIRNLNGHSIGPYIIHGGKSVp 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  202 IQNPTDQQKkdhekaeFEVHEVYAVDVLVSSGEGKAKDAGQrTTIYKRDPSKQYG-LKMKTSRAFFSEVERRFDAMPFTL 280
Cdd:PTZ00053 338 IVKGGENTR-------MEEGELFAIETFASTGRGYVNEDLE-CSHYMKDPGAEFVpLRLPKAKQLLKHINTNFGTLAFCR 409

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 14043147  281 RAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 329
Cdd:PTZ00053 410 RWLDRlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
76-188 1.70e-14

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 72.73  E-value: 1.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVdvaqGTqVTGRKADVIKAAHLCAEAA 153
Cdd:COG0024  62 FPKSIctSVNEVVVHGIP----SDRVLKDGDIVNIDVGAILDGYHGDSARTFVV----GE-VSPEARRLVEVTEEALYAG 132

                        90       100       110
                ....*....|....*....|....*....|....*
gi 14043147 154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:COG0024 133 IAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGH 167
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 25-174 1.93e-14

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 71.50  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147    25 GDIANRVLRSLVEAsssgvsvlslCEKG------DAMIMEetgkiFKKEKEMKKGIAFPTSI--SVNNCVCHFSPLksdq 96
Cdd:pfam00557   7 ARIAAAALEAALAA----------IRPGvterelAAELEA-----ARLRRGGARGPAFPPIVasGPNAAIPHYIPN---- 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14043147    97 DYILKEGDLVKIDLGVHVD-GFIANVAHTFVVDvaqgtQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVA 174
Cdd:pfam00557  68 DRVLKPGDLVLIDVGAEYDgGYCSDITRTFVVG-----KPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL 141
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 1-388 0e+00

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 640.78  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147     1 MSGEDEQQEQ--TIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPT 78
Cdd:TIGR00495   1 MSGKDEQQEQaySLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147    79 SISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVK 158
Cdd:TIGR00495  81 CISVNNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   159 PGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAK 238
Cdd:TIGR00495 161 PGNTNTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   239 DAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQ 318
Cdd:TIGR00495 241 DADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQ 320

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   319 FKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLE 388
Cdd:TIGR00495 321 FKFTVLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPIKRKKQKKKAKKASKTGEAATEGETME 390
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 18-334 6.97e-118

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 342.00  E-value: 6.97e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  18 VTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQD 97
Cdd:cd01089   1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  98 YILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSF 177
Cdd:cd01089  81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147 178 NCTPIEGMLSHQLKQhvidgektiiqnptdqqkkdhekaefevhevyavdvLVSSGEGKAKdagqrttiykrdpskqygl 257
Cdd:cd01089 161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 14043147 258 kmktsraffseverrfdampftlrafedekkarmgVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRIT 334
Cdd:cd01089 186 -----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLT 227
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 20-329 4.80e-46

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 159.72  E-value: 4.80e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  20 KYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGkifkkekemkkGIAFPTSISVNNCVCHFSPLKSDqDYI 99
Cdd:cd01088   3 KYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGA-----------GPAFPVNLSINECAAHYTPNAGD-DTV 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147 100 LKEGDLVKIDLGVHVDGFIANVAhtFVVDVAQGTQvtgrkaDVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNC 179
Cdd:cd01088  71 LKEGDVVKLDFGAHVDGYIADSA--FTVDFDPKYD------DLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGF 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147 180 TPIEGMLSHQLKQHVIDGEKTIiqnPTDqqkKDHEKAEFEVHEVYAVDVLVSSGEGKAKDaGQRTTIYKRDPSKQYGLKM 259
Cdd:cd01088 143 KPIRNLTGHSIERYRLHAGKSI---PNV---KGGEGTRLEEGDVYAIEPFATTGKGYVHD-GPECSIYMLNRDKPLRLPR 215

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14043147 260 ktSRAFFSEVERRFDAMPFTLRAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 329
Cdd:cd01088 216 --ARKLLDVIYENFGTLPFARRWLDRlgETKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDG 285
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 62-329 2.70e-20

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 92.08  E-value: 2.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   62 KIFKKEKEM------KKGIAFPTSISVNNCVCHFSPLKSDqDYILKEGDLVKIDLGVHVDGFIANVAHTFVVD-----VA 130
Cdd:PTZ00053 191 RIESKSRELieadglKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDCAFTVAFNpkydpLL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  131 QGTQ---VTGrkadvIKAAHLCAeaalRLVKPGNQNTQVTEAW-----NKVahsFNCTPIEGMLSHQLKQHVIDGEKTI- 201
Cdd:PTZ00053 270 QATKdatNTG-----IKEAGIDV----RLSDIGAAIQEVIESYeveikGKT---YPIKSIRNLNGHSIGPYIIHGGKSVp 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  202 IQNPTDQQKkdhekaeFEVHEVYAVDVLVSSGEGKAKDAGQrTTIYKRDPSKQYG-LKMKTSRAFFSEVERRFDAMPFTL 280
Cdd:PTZ00053 338 IVKGGENTR-------MEEGELFAIETFASTGRGYVNEDLE-CSHYMKDPGAEFVpLRLPKAKQLLKHINTNFGTLAFCR 409

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 14043147  281 RAFED--EKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNG 329
Cdd:PTZ00053 410 RWLDRlgQDRHLLALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 76-188 3.22e-17

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 80.23  E-value: 3.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVdvaqGTqVTGRKADVIKAAHLCAEAA 153
Cdd:cd01086  54 FPKSIctSVNEVVCHGIP----DDRVLKDGDIVNIDVGVELDGYHGDSARTFIV----GE-VSEEAKKLVEVTEEALYKG 124

                        90       100       110
                ....*....|....*....|....*....|....*
gi 14043147 154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:cd01086 125 IEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGH 159
PRK05716 PRK05716
methionine aminopeptidase; Validated
 76-188 4.67e-16

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 77.10  E-value: 4.67e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVdvaqGTqVTGRKADVIKAAHLCAEAA 153
Cdd:PRK05716  64 FPKSIctSVNEVVCHGIP----SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGV----GE-ISPEDKRLCEVTKEALYLG 134

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 14043147  154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:PRK05716 135 IAAVKPGARLGDIGHAIQKYAEAEGFSVVREYCGH 169
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
76-188 1.70e-14

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 72.73  E-value: 1.70e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVdvaqGTqVTGRKADVIKAAHLCAEAA 153
Cdd:COG0024  62 FPKSIctSVNEVVVHGIP----SDRVLKDGDIVNIDVGAILDGYHGDSARTFVV----GE-VSPEARRLVEVTEEALYAG 132

                        90       100       110
                ....*....|....*....|....*....|....*
gi 14043147 154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:COG0024 133 IAAAKPGNRLGDIGHAIQSYAESNGYSVVREFVGH 167
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 25-174 1.93e-14

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 71.50  E-value: 1.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147    25 GDIANRVLRSLVEAsssgvsvlslCEKG------DAMIMEetgkiFKKEKEMKKGIAFPTSI--SVNNCVCHFSPLksdq 96
Cdd:pfam00557   7 ARIAAAALEAALAA----------IRPGvterelAAELEA-----ARLRRGGARGPAFPPIVasGPNAAIPHYIPN---- 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 14043147    97 DYILKEGDLVKIDLGVHVD-GFIANVAHTFVVDvaqgtQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVA 174
Cdd:pfam00557  68 DRVLKPGDLVLIDVGAEYDgGYCSDITRTFVVG-----KPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVL 141
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 18-181 5.61e-14

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 70.18  E-value: 5.61e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  18 VTKYKMGGDIANRVLRSLVEAsssgvsvlslCEKGDAMImEETGKIFKKEKEMKKGIAFPTSISVNN--CVCHFSPlksd 95
Cdd:cd01066   1 IARLRKAAEIAEAAMAAAAEA----------IRPGVTEA-EVAAAIEQALRAAGGYPAGPTIVGSGArtALPHYRP---- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  96 QDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDvaqgtQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAH 175
Cdd:cd01066  66 DDRRLQEGDLVLVDLGGVYDGYHADLTRTFVIG-----EPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLE 140


                ....*.
gi 14043147 176 SFNCTP 181
Cdd:cd01066 141 EHGLGP 146
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 76-188 1.88e-11

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 63.52  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147    76 FPTS--ISVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDvaqgtQVTGRKADVIKAAHLCAEAA 153
Cdd:TIGR00500  62 FPGSvcISVNEVVIHGIP----DKKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVG-----KISPEAEKLLECTEESLYKA 132

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 14043147   154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:TIGR00500 133 IEEAKPGNRIGEIGAAIQKYAEAKGFSVVREYCGH 167
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 6-188 1.44e-10

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 61.01  E-value: 1.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147    6 EQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASssgvsvlslcEKG------DAM---IMEETGKI--FKKEKemkkgi 74
Cdd:PRK12896   4 EGRGMEIKSPRELEKMRKIGRIVATALKEMGKAV----------EPGmttkelDRIaekRLEEHGAIpsPEGYY------ 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   75 AFPTS--ISVNNCVCHFSPlkSDQdyILKEGDLVKIDLGVHVDGFIANVAHTFVVDvaqgtQVTGRKADVIKAAHLCAEA 152
Cdd:PRK12896  68 GFPGStcISVNEEVAHGIP--GPR--VIKDGDLVNIDVSAYLDGYHGDTGITFAVG-----PVSEEAEKLCRVAEEALWA 138

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 14043147  153 ALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:PRK12896 139 GIKQVKAGRPLNDIGRAIEDFAKKNGYSVVRDLTGH 174
PRK12318 PRK12318
methionyl aminopeptidase;
76-188 5.49e-08

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 53.67  E-value: 5.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   76 FPTSI--SVNNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDvaqgtQVTGRKADVIKAAHLCAEAA 153
Cdd:PRK12318 104 FPKTIctSLNEVICHGIP----NDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIG-----EVSEIKKKVCQASLECLNAA 174

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 14043147  154 LRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSH 188
Cdd:PRK12318 175 IAILKPGIPLYEIGEVIENCADKYGFSVVDQFVGH 209
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
67-173 3.31e-06

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 48.28  E-value: 3.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  67 EKEMKK----GIAFPTSISV--NNCVCHFSPlksdQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQvtgRKA 140
Cdd:COG0006 114 EAAMRRrgaeGPSFDTIVASgeNAAIPHYTP----TDRPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQ---REI 186

                        90       100       110
                ....*....|....*....|....*....|....
gi 14043147 141 -DVIKAAHlcaEAALRLVKPGNQNTQVTEAWNKV 173
Cdd:COG0006 187 yEAVLEAQ---EAAIAALKPGVTGGEVDAAARDV 217
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 77-190 9.37e-05

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 43.33  E-value: 9.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  77 PTSIS-VNNCVCHFSPLksdqDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDvaqGtQVTGRKADVIKAAHLCAEAALR 155
Cdd:cd01087  50 YIVAAgSNAAILHYVHN----DQPLKDGDLVLIDAGAEYGGYASDITRTFPVN---G-KFTDEQRELYEAVLAAQKAAIA 121

                        90       100       110
                ....*....|....*....|....*....|....*
gi 14043147 156 LVKPGNQNTQVTEAWNKVAHsfnctpiEGMLSHQL 190
Cdd:cd01087 122 ACKPGVSYEDIHLLAHRVLA-------EGLKELGI 149
PRK15173 PRK15173
peptidase; Provisional
 89-160 9.46e-05

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 43.94  E-value: 9.46e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14043147   89 FSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVvdVAQGTQVTGRKADVIKAAHlcaEAALRLVKPG 160
Cdd:PRK15173 159 FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFV--VGEPPEITRKIYQTIRTGH---EHMLSMVAPG 225
PRK14575 PRK14575
putative peptidase; Provisional
 89-160 1.35e-04

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 43.93  E-value: 1.35e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 14043147   89 FSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVvdVAQGTQVTGRKADVIKAAHlcaEAALRLVKPG 160
Cdd:PRK14575 242 FSPKLIPSNTKACSGDLIKFDCGVDVDGYGADIARTFV--VGEPPEITRKIYQTIRTGH---EHMLSMVAPG 308
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 67-160 5.88e-04

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 40.96  E-value: 5.88e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147  67 EKEMKK----GIAFPTSIS--VNNCVCHFSPlkSDQdyILKEGDLVKIDLGVHVDGFIANVAHTFVVdvaqgtqvtGRKA 140
Cdd:cd01092  36 EYFMRKlgaeGPSFDTIVAsgPNSALPHGVP--SDR--KIEEGDLVLIDFGAIYDGYCSDITRTVAV---------GEPS 102

                        90       100
                ....*....|....*....|....
gi 14043147 141 DVIKAAH---LCA-EAALRLVKPG 160
Cdd:cd01092 103 DELKEIYeivLEAqQAAIKAVKPG 126
PRK14576 PRK14576
putative endopeptidase; Provisional
 88-160 3.60e-03

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 39.23  E-value: 3.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 14043147   88 HFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVvdVAQGTQVTGRKADVIKAAHlcaEAALRLVKPG 160
Cdd:PRK14576 240 NFSPKIIADTTPAKVGDLIKFDCGIDVAGYGADLARTFV--LGEPDKLTQQIYDTIRTGH---EHMLSMVAPG 307
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 83-169 4.33e-03

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 38.94  E-value: 4.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14043147   83 NNCVCHFSPLKSDqdyiLKEGDLVKIDLGVHVDGFIANVAHTFVVDvAQGTQVTGRKADVIKAAhlcAEAALRLVKPGNQ 162
Cdd:PRK10879 236 NGCILHYTENESE----MRDGDLVLIDAGCEYKGYAGDITRTFPVN-GKFTPAQREIYDIVLES---LETSLRLYRPGTS 307


                 ....*..
gi 14043147  163 NTQVTEA 169
Cdd:PRK10879 308 IREVTGE 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH