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Conserved domains on  [gi|17389477|gb|AAH17780|]
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CYTH4 protein [Homo sapiens]

Protein Classification

Sec7 domain-containing protein( domain architecture ID 10475578)

Sec7 domain-containing protein may function as a guanine-nucleotide-exchange factor (GEF) for members of the ARF class of small GTPases

CATH:  1.10.1000.11
Gene Ontology:  GO:0005085|GO:0032012
PubMed:  10652516
SCOP:  4001318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 61-118 1.01e-19

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


:

Pssm-ID: 460178  Cd Length: 183  Bit Score: 79.43  E-value: 1.01e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17389477    61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGER 118
Cdd:pfam01369   1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKP 58
 
Name Accession Description Interval E-value
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 61-118 1.01e-19

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 79.43  E-value: 1.01e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17389477    61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGER 118
Cdd:pfam01369   1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKP 58
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 61-118 2.21e-15

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 68.02  E-value: 2.21e-15
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17389477  61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDV-QDIARFLYKGEGLNKTAIGTYLGER 118
Cdd:cd00171   1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLEDDSpKEIAKFLYETEGLNKKAIGEYLGEN 59
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 60-118 7.10e-12

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 58.84  E-value: 7.10e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17389477     60 QKEKELCIGRKKFNMDPAKGIQYFIEHKLL-TPDVQDIARFLYKGEGLNKTAIGTYLGER 118
Cdd:smart00222   3 GRKKLLSEGIVKFNDKPKKGIQSLQEKGFLaNEDPQDVADFLSKNEGLNKKAIGDYLGEH 62
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 52-118 4.70e-10

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 55.60  E-value: 4.70e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17389477    52 SAEESRMAQKeKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGER 118
Cdd:PLN03076  608 ATIEQRRAYK-LELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGER 673
 
Name Accession Description Interval E-value
Sec7 pfam01369
Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 ...
 61-118 1.01e-19

Sec7 domain; The Sec7 domain is a guanine-nucleotide-exchange-factor (GEF) for the pfam00025 family.


Pssm-ID: 460178  Cd Length: 183  Bit Score: 79.43  E-value: 1.01e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 17389477    61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGER 118
Cdd:pfam01369   1 RKKLLREGIEKFNKKPKKGIEYLIEKGFIEDDPESIAKFLFETPGLDKKAIGEYLGKP 58
Sec7 cd00171
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
 61-118 2.21e-15

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.


Pssm-ID: 238100  Cd Length: 185  Bit Score: 68.02  E-value: 2.21e-15
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17389477  61 KEKELCIGRKKFNMDPAKGIQYFIEHKLLTPDV-QDIARFLYKGEGLNKTAIGTYLGER 118
Cdd:cd00171   1 RKTLLSEGRQLFNRKPKKGISFLIEKGFLEDDSpKEIAKFLYETEGLNKKAIGEYLGEN 59
Sec7 smart00222
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
 60-118 7.10e-12

Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).


Pssm-ID: 214569 [Multi-domain]  Cd Length: 189  Bit Score: 58.84  E-value: 7.10e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17389477     60 QKEKELCIGRKKFNMDPAKGIQYFIEHKLL-TPDVQDIARFLYKGEGLNKTAIGTYLGER 118
Cdd:smart00222   3 GRKKLLSEGIVKFNDKPKKGIQSLQEKGFLaNEDPQDVADFLSKNEGLNKKAIGDYLGEH 62
PLN03076 PLN03076
ARF guanine nucleotide exchange factor (ARF-GEF); Provisional
 52-118 4.70e-10

ARF guanine nucleotide exchange factor (ARF-GEF); Provisional


Pssm-ID: 215560 [Multi-domain]  Cd Length: 1780  Bit Score: 55.60  E-value: 4.70e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17389477    52 SAEESRMAQKeKELCIGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGER 118
Cdd:PLN03076  608 ATIEQRRAYK-LELQEGISLFNRKPKKGIEFLINANKVGESPEEIAAFLKDASGLNKTLIGDYLGER 673
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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