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Conserved domains on  [gi|18044139|gb|AAH19553|]
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RIKEN cDNA 2210407C18 gene [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 123-180 4.72e-14

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467102  Cd Length: 80  Bit Score: 64.76  E-value: 4.72e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044139 123 NGVECPACYNNKTNTCSTTTPLKCTGAEKRCIEVTS--RDLSSNIVMYGKGCATENACAL 180
Cdd:cd23572   1 NGLQCPACYSEGSDSCKSEETVNCTGEETQCIEFSGtiSGGGSSVKFAMKGCATESACDL 60
 
Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 123-180 4.72e-14

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 64.76  E-value: 4.72e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044139 123 NGVECPACYNNKTNTCSTTTPLKCTGAEKRCIEVTS--RDLSSNIVMYGKGCATENACAL 180
Cdd:cd23572   1 NGLQCPACYSEGSDSCKSEETVNCTGEETQCIEFSGtiSGGGSSVKFAMKGCATESACDL 60
 
Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 123-180 4.72e-14

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 64.76  E-value: 4.72e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18044139 123 NGVECPACYNNKTNTCSTTTPLKCTGAEKRCIEVTS--RDLSSNIVMYGKGCATENACAL 180
Cdd:cd23572   1 NGLQCPACYSEGSDSCKSEETVNCTGEETQCIEFSGtiSGGGSSVKFAMKGCATESACDL 60
TFP_LU_ECD_uPAR_rpt3 cd23558
third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 119-178 2.70e-03

third extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467088  Cd Length: 93  Bit Score: 35.83  E-value: 2.70e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18044139 119 SSEVNGVECPACYNNKTNTCST--TTPLKCTGAEKRCIEV--TSRDLSSNIVMYGKGCATENAC 178
Cdd:cd23558   2 DLPPNGIQCYSCNGNSTHGCSSeeTSKVRCRGPQTQCLEAtgTTAHGGKNQSYMVKGCATPSMC 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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