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Conserved domains on  [gi|18204410|gb|AAH21527|]
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Zinc finger protein 52 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-574 1.67e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 143 KPYQCGHCRKYFSTTSSLSIHQRIHTGEKPYKCN--ICGKSFNQWSSLKTDQTLHTAKKPYKCKEGGKLlvQLSALKSHQ 220
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 221 RRHTGEKPYKCQQCD-RSFAHCASLRWHQKIHSPEIHYECKE--------CGKSCFELSHLKRHcrIHTAEKPYRYEVCD 291
Cdd:COG5048 110 LSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvNTPQSNSLHPPLPA--NSLSKDPSSNLSLL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 292 TSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLrtyqrvhtgkRPYRCTECDKFFTKHSNLRQHQKIHTGEKPPKC 371
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS----------SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 372 KDCDKSFLrissvrirqkihagerryrckeCGRSFTWFSNLRVHQRVHTGER-PYRCKECGKSFTTGSNLRVHQ--KIHT 448
Cdd:COG5048 258 SESPRSSL----------------------PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHS 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 449 GE--KPYKC--KDCDISFLWISNLRTHQKIHTGEKPYKC--QECNKSFTRCS------YLRDHQKIHTGEKLYKCKDCDI 516
Cdd:COG5048 316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSNSCI 395

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18204410 517 SFMW---ISSLRRHQKIHTGEKPYKCRGCEKSFTQCSTLRDHQKIHTGEKPYKCKDCGISF 574
Cdd:COG5048 396 RNFKrdsNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
607-632 8.70e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 18204410   607 NLRTHQKIHTGEKPYKCQECNKSFTR 632
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
579-602 3.18e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|....
gi 18204410   579 SLRRHQKIHTGEKPYKCKDCDISF 602
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-574 1.67e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 143 KPYQCGHCRKYFSTTSSLSIHQRIHTGEKPYKCN--ICGKSFNQWSSLKTDQTLHTAKKPYKCKEGGKLlvQLSALKSHQ 220
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 221 RRHTGEKPYKCQQCD-RSFAHCASLRWHQKIHSPEIHYECKE--------CGKSCFELSHLKRHcrIHTAEKPYRYEVCD 291
Cdd:COG5048 110 LSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvNTPQSNSLHPPLPA--NSLSKDPSSNLSLL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 292 TSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLrtyqrvhtgkRPYRCTECDKFFTKHSNLRQHQKIHTGEKPPKC 371
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS----------SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 372 KDCDKSFLrissvrirqkihagerryrckeCGRSFTWFSNLRVHQRVHTGER-PYRCKECGKSFTTGSNLRVHQ--KIHT 448
Cdd:COG5048 258 SESPRSSL----------------------PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHS 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 449 GE--KPYKC--KDCDISFLWISNLRTHQKIHTGEKPYKC--QECNKSFTRCS------YLRDHQKIHTGEKLYKCKDCDI 516
Cdd:COG5048 316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSNSCI 395

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18204410 517 SFMW---ISSLRRHQKIHTGEKPYKCRGCEKSFTQCSTLRDHQKIHTGEKPYKCKDCGISF 574
Cdd:COG5048 396 RNFKrdsNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 6.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.23e-04
                          10        20
                  ....*....|....*....|....*.
gi 18204410   215 ALKSHQRRHTGEKPYKCQQCDRSFAH 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
607-632 8.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 18204410   607 NLRTHQKIHTGEKPYKCQECNKSFTR 632
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 399-447 1.66e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 1.66e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 18204410 399 CKECGRSFTWFSNLRVHQRVHTgerpYRCKECGKSFTTGSNLRVH-QKIH 447
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
579-602 3.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|....
gi 18204410   579 SLRRHQKIHTGEKPYKCKDCDISF 602
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
143-574 1.67e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 1.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 143 KPYQCGHCRKYFSTTSSLSIHQRIHTGEKPYKCN--ICGKSFNQWSSLKTDQTLHTAKKPYKCKEGGKLlvQLSALKSHQ 220
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 221 RRHTGEKPYKCQQCD-RSFAHCASLRWHQKIHSPEIHYECKE--------CGKSCFELSHLKRHcrIHTAEKPYRYEVCD 291
Cdd:COG5048 110 LSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvNTPQSNSLHPPLPA--NSLSKDPSSNLSLL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 292 TSITVNSTLKTHHKIHTREKPYRYRECDKSITKCSYLrtyqrvhtgkRPYRCTECDKFFTKHSNLRQHQKIHTGEKPPKC 371
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSS----------SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 372 KDCDKSFLrissvrirqkihagerryrckeCGRSFTWFSNLRVHQRVHTGER-PYRCKECGKSFTTGSNLRVHQ--KIHT 448
Cdd:COG5048 258 SESPRSSL----------------------PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLrsVNHS 315

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 449 GE--KPYKC--KDCDISFLWISNLRTHQKIHTGEKPYKC--QECNKSFTRCS------YLRDHQKIHTGEKLYKCKDCDI 516
Cdd:COG5048 316 GEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSNSCI 395

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18204410 517 SFMW---ISSLRRHQKIHTGEKPYKCRGCEKSFTQCSTLRDHQKIHTGEKPYKCKDCGISF 574
Cdd:COG5048 396 RNFKrdsNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
281-672 6.37e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 6.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 281 AEKPYRYEVCDTSITVNSTLKTHHKIHTREKPY--RYRECDKSITKCSYLRTYQRVHTGKRPYRCteCDKFFTKHSNLRQ 358
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASS 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 359 HQKIHTGEKPPKCKDCDKSFLRISSVRIRQKIHAGERRYRCKECGRSFTWFSNLRVHQRVHTgerPYRCKECGKSFTTGS 438
Cdd:COG5048 108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP---PLPANSLSKDPSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 439 NLRVHQKIHTGEKPYKCKDCDISFLWISNLRTHQKIHTGEKPYKCQECNKSFTRCSYLRDHQKIHTGEKLYKCKDCDISF 518
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 519 MWISSLRRHQKIHTGE-------KPYKCRGCEKSFTQCSTLRDHQ--KIHTGE--KPYKC--KDCGISFLWISSLRRHQK 585
Cdd:COG5048 265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 586 IHTGEKPYKCKDC----DISFLWISNLRTHQKIHTGEKPYKCQE-----CNKSFTRCSYLRVHQRTHSGEKLYKCEN--C 654
Cdd:COG5048 345 LHTSISPAKEKLLnsssKFSPLLNNEPPQSLQQYKDLKNDKKSEtlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKNppC 424

                       410
                ....*....|....*...
gi 18204410 655 DVSFMWISNLRRHQKIHT 672
Cdd:COG5048 425 SKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-659 1.37e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.37e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 227 KPYKCQQCDRSFAHCASLRWHQKIHSPEIHYEC--KECGKSCFELSHLKRHCRIHTAEKPYRyeVCDTSITVNSTL---K 301
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL--NSKSLPLSNSKAsssS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 302 THHKIHTREKPYRYRECDKSITKCSYLRTYQRVHTGKRPYRCTEC--DKFFTKHSNLRQHQKIHTGEKPPKCKDcdksfl 379
Cdd:COG5048 110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsSSVNTPQSNSLHPPLPANSLSKDPSSN------ 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 380 riSSVRIRQKIHAGERRYRCKECGRSFTWFSNLRVHQRVHTGERPYRCKECGKSFTTGSNLRVHQKIHTGEKPYKCKDCD 459
Cdd:COG5048 184 --LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 460 ISFLWISNLRTHQKIHTGE-------KPYKCQECNKSFTRCSYLRDHQ--KIHTGEKLYKC----KDCDISFMWISSLRR 526
Cdd:COG5048 262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFscpySLCGKLFSRNDALKR 341

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 527 HQKIHTGEKPYKC--RGCEKSFTQCSTLRDHQKI--HTGEKPYKCKDCGISFLWISSLRRHqkihtgekpykckdcdisf 602
Cdd:COG5048 342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDS------------------- 402

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 18204410 603 lwISNLRTHQKIHTGEKPYKCQECNKSFTRCSYLRVHQRTHSGEKLYKCENCDVSFM 659
Cdd:COG5048 403 --NLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 6.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.23e-04
                          10        20
                  ....*....|....*....|....*.
gi 18204410   215 ALKSHQRRHTGEKPYKCQQCDRSFAH 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
523-548 8.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.12e-04
                          10        20
                  ....*....|....*....|....*.
gi 18204410   523 SLRRHQKIHTGEKPYKCRGCEKSFTQ 548
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-492 8.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 18204410   467 NLRTHQKIHTGEKPYKCQECNKSFTR 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
607-632 8.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 18204410   607 NLRTHQKIHTGEKPYKCQECNKSFTR 632
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-436 8.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.96e-04
                          10        20
                  ....*....|....*....|....*.
gi 18204410   411 NLRVHQRVHTGERPYRCKECGKSFTT 436
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 399-447 1.66e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 1.66e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 18204410 399 CKECGRSFTWFSNLRVHQRVHTgerpYRCKECGKSFTTGSNLRVH-QKIH 447
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
579-602 3.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|....
gi 18204410   579 SLRRHQKIHTGEKPYKCKDCDISF 602
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
159-184 3.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 18204410   159 SLSIHQRIHTGEKPYKCNICGKSFNQ 184
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 136-252 3.89e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 136 ETVDMEEKPYQCGHCRKYFSTTSSLSIH---QRIHT-GEKPYKCNI--CGKSFNQWSSLKtdqtlhtakkpYKCKEG--G 207
Cdd:COG5189 309 EMIDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPVegCNKKYKNQNGLK-----------YHMLHGhqN 377

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 18204410 208 KLLVQLSALKSHQRRHTGEKPYKCQQCDRSFAHCASLRWHQKiHS 252
Cdd:COG5189 378 QKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 477-557 5.84e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18204410 477 GEKPYKCQ--ECNKSFTRCSYLRDHQKI-HTGEKLYKCKDCDisfmwisslrRHQKIHTGEKPYKCRGCEKSFTQCSTLR 553
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPE----------KMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....
gi 18204410 554 DHQK 557
Cdd:COG5189 416 YHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-462 6.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.84e-03
                          10        20
                  ....*....|....*....|....
gi 18204410   439 NLRVHQKIHTGEKPYKCKDCDISF 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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