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Conserved domains on  [gi|19263503|gb|AAH25392|]
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WD repeat domain 16 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-614 2.23e-43

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 2.23e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 291 GGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVKDIVF-PFGTAeLFATCAKKDIRVWHTSSNRELLR 369
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFsPDGKT-LASGSADGTVRLWDLATGKLLRT 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 370 ITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINnAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIgcQ 449
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--A 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 450 TQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAY 528
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 529 WEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSAD 608
Cdd:COG2319 315 WDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393


                ....*.
gi 19263503 609 GAILRW 614
Cdd:COG2319 394 GTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
55-188 1.33e-13

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 1.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503  55 KEQNFLQGHGNNVSCLAISRSGEYIASGqvtfmGFKVDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSlgGPDD 134
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASG-----SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS--GSDD 351

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19263503 135 GSVVVWSIAkrDAICGSPAAGlNVGNATNVIFSRcRDEMFMTAG-NGTIRVWELD 188
Cdd:COG2319 352 GTVRLWDLA--TGELLRTLTG-HTGAVTSVAFSP-DGRTLASGSaDGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-614 2.23e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 2.23e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 291 GGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVKDIVF-PFGTAeLFATCAKKDIRVWHTSSNRELLR 369
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFsPDGKT-LASGSADGTVRLWDLATGKLLRT 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 370 ITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINnAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIgcQ 449
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--A 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 450 TQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAY 528
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 529 WEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSAD 608
Cdd:COG2319 315 WDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393


                ....*.
gi 19263503 609 GAILRW 614
Cdd:COG2319 394 GTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 346-615 2.46e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 2.46e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 346 ELFATCAK-KDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINnAHRIGVTAIA 424
Cdd:cd00200  22 KLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT-GHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 425 TTSDCKRVISGGGEGEVRVWQIgcQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 504
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 505 F-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVG 583
Cdd:cd00200 179 EvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257

                       250       260       270
                ....*....|....*....|....*....|..
gi 19263503 584 VGHSGNITRIRISPGNQYIVSVSADGAILRWK 615
Cdd:cd00200 258 SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
55-188 1.33e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 1.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503  55 KEQNFLQGHGNNVSCLAISRSGEYIASGqvtfmGFKVDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSlgGPDD 134
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASG-----SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS--GSDD 351

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19263503 135 GSVVVWSIAkrDAICGSPAAGlNVGNATNVIFSRcRDEMFMTAG-NGTIRVWELD 188
Cdd:COG2319 352 GTVRLWDLA--TGELLRTLTG-HTGAVTSVAFSP-DGRTLASGSaDGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 450-489 1.26e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19263503    450 TQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWD 489
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-141 2.72e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.72e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 19263503    100 NRELLARLSLHKGKIEALAFSPNDLYLVSLGgpDDGSVVVWS 141
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
457-489 4.78e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 4.78e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 19263503   457 LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWD 489
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
101-141 9.01e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 9.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19263503   101 RELLARLSLHKGKIEALAFSPNDLYLVSlGGpDDGSVVVWS 141
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLAS-GS-DDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-614 2.23e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 2.23e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 291 GGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVKDIVF-PFGTAeLFATCAKKDIRVWHTSSNRELLR 369
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFsPDGKT-LASGSADGTVRLWDLATGKLLRT 157

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 370 ITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINnAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIgcQ 449
Cdd:COG2319 158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDL--A 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 450 TQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIAY 528
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNSVAFSPDGKLLASGSDDGTVRL 314

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 529 WEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSAD 608
Cdd:COG2319 315 WDLATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393


                ....*.
gi 19263503 609 GAILRW 614
Cdd:COG2319 394 GTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
323-614 2.44e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 2.44e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 323 KETLIATCHFDAVKDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFA 402
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 403 PETGRLMYVINnAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIgcQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTD 482
Cdd:COG2319 149 LATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 483 GTCIIWDLVRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSlSGSINGMDITQEGVHFV 561
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTGHSGSvRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLA 304

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 19263503 562 TGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
331-614 1.54e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.20  E-value: 1.54e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 331 HFDAVKDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMY 410
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 411 VInNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIgcQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL 490
Cdd:COG2319 115 TL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 491 VRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLV 569
Cdd:COG2319 192 ATGKLLRTLTGHTGAvRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH-SGSVRSVAFSPDGRLLASGSADGTV 270

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 19263503 570 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
Cdd:COG2319 271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 346-615 2.46e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 2.46e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 346 ELFATCAK-KDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINnAHRIGVTAIA 424
Cdd:cd00200  22 KLLATGSGdGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT-GHTSYVSSVA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 425 TTSDCKRVISGGGEGEVRVWQIgcQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTL 504
Cdd:cd00200 101 FSPDGRILSSSSRDKTIKVWDV--ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG 178

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 505 F-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVG 583
Cdd:cd00200 179 EvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL 257

                       250       260       270
                ....*....|....*....|....*....|..
gi 19263503 584 VGHSGNITRIRISPGNQYIVSVSADGAILRWK 615
Cdd:cd00200 258 SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 380-614 3.17e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.99  E-value: 3.17e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 380 IDFMRDGKSIISAWNDGKIRAFAPETGRLMYViNNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIgcQTQKLEEALKE 459
Cdd:cd00200  15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL--ETGECVRTLTG 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 460 HKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLF-QCVCYHPEEFQIITSGTDRKIAYWEVFDGTVIR 538
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWvNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19263503 539 ELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
Cdd:cd00200 172 TLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
290-573 7.48e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.80  E-value: 7.48e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 290 QGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDAVKDIVF-PFGTAeLFATCAKKDIRVWHTSSNRELL 368
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFsPDGKL-LASGSDDGTVRLWDLATGKLLR 198

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 369 RITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINnAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIgc 448
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-- 275

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 449 QTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANT-LFQCVCYHPEEFQIITSGTDRKIA 527
Cdd:COG2319 276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVR 355

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 19263503 528 YWEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWD 573
Cdd:COG2319 356 LWDLATGELLRTLTGH-TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 416-614 3.69e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 3.69e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 416 HRIGVTAIATTSDCKRVISGGGEGEVRVWQIgcQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLvrlrr 495
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL----- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 496 NQMILANTLFQ------CVCYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLV 569
Cdd:cd00200  81 ETGECVRTLTGhtsyvsSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 19263503 570 KVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
Cdd:cd00200 160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
46-490 7.39e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.25  E-value: 7.39e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503  46 TVLIQAINTKEQNFLQGHGNNVSCLAISRSGEYIASGqvtfmGFKVDIILWDYKNRELLARLSLHKGKIEALAFSPNDLY 125
Cdd:COG2319  60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA-----SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 126 LVSlgGPDDGSVVVWSIAKrdaicGSPAAGLNVGNA--TNVIFSRcrD-EMFMTAG-NGTIRVWELDlpnrkiwptesqT 201
Cdd:COG2319 135 LAS--GSADGTVRLWDLAT-----GKLLRTLTGHSGavTSVAFSP--DgKLLASGSdDGTVRLWDLA------------T 193

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 202 GQLkrivmsigvddddsffyLGTTTGDilkmnprTKLLTDVGPAKDkfslgvsairclkmGGLLVGSGAGllvfckspgy 281
Cdd:COG2319 194 GKL-----------------LRTLTGH-------TGAVRSVAFSPD--------------GKLLASGSAD---------- 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 282 KPIKKIQLQGGITSITLRGEGHQflvgteeshIYRVSFTDfKETLIATCHFDavkdivfpfGTaelfatcakkdIRVWHT 361
Cdd:COG2319 226 GTVRLWDLATGKLLRTLTGHSGS---------VRSVAFSP-DGRLLASGSAD---------GT-----------VRLWDL 275

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 362 SSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVINnAHRIGVTAIATTSDCKRVISGGGEGEV 441
Cdd:COG2319 276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTV 354

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*....
gi 19263503 442 RVWQIgcQTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL 490
Cdd:COG2319 355 RLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 291-573 1.81e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.51  E-value: 1.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 291 GGITSITLRGEGHQFLVGTEES--HIYRVSFTDFKETLIAtcHFDAVKDIVFPFGTAELFATCAKKDIRVWHTSSNRELL 368
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGtiKVWDLETGELLRTLKG--HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 369 RITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVInNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIgc 448
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL-- 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 449 QTQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLvrlrRNQMILA-----NTLFQCVCYHPEEFQIITSGTD 523
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL----STGKCLGtlrghENGVNSVAFSPDGYLLASGSED 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 19263503 524 RKIAYWEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWD 573
Cdd:cd00200 241 GTIRVWDLRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
339-614 9.18e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 9.18e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 339 VFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISAWNDGKIRAFAPETGRLmYVINNAHRI 418
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGAL-LATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 419 GVTAIATTSDCKRVISGGGEGEVRVWQIgcQTQKLEEALKEHKSSVSCIRVkrnneecvtaSTDGTciiwdlvrlrrnqm 498
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAF----------SPDGK-------------- 133

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 499 ilantlfqcvcyhpeefQIITSGTDRKIAYWEVFDGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGE 578
Cdd:COG2319 134 -----------------TLASGSADGTVRLWDLATGKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 19263503 579 VTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
Cdd:COG2319 196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-530 1.28e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 1.28e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503  60 LQGHGNNVSCLAISRSGEYIASGQVtfmgfkvD--IILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSlGGPDdgsv 137
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSG-------DgtIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSD---- 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 138 vvwsiakrdaicgspaaglnvgnatnvifsrcrdemfmtagnGTIRVWELdlpnrkiwptesQTGQLKRIVmsigvdddd 217
Cdd:cd00200  73 ------------------------------------------KTIRLWDL------------ETGECVRTL--------- 89

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 218 sffylgtttgdilkmnprtklltdvgpakdkfslgvsairclkmggllvgsgagllvfckspgykpikkiqlqggitsit 297
Cdd:cd00200     --------------------------------------------------------------------------------

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 298 lrgEGHqflvgteESHIYRVSFTDfKETLIATCHFDavkdivfpfgtaelfatcakKDIRVWHTSSNRELLRITVPNMTC 377
Cdd:cd00200  90 ---TGH-------TSYVSSVAFSP-DGRILSSSSRD--------------------KTIKVWDVETGKCLTTLRGHTDWV 138

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 378 HGIDFMRDGKSIISAWNDGKIRAFAPETGRLMYVInNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIgcQTQKLEEAL 457
Cdd:cd00200 139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATL-TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL--STGKCLGTL 215

                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19263503 458 KEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILA-NTLFQCVCYHPEEFQIITSGTDRKIAYWE 530
Cdd:cd00200 216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 457-614 6.67e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 6.67e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 457 LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDL--VRLRRNQMILANTLFQCVCYHPEEfQIITSGTDRKIAYWEVFDG 534
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLetGELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETG 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 535 TVIRELEGSLSGsINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
Cdd:cd00200  84 ECVRTLTGHTSY-VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
55-188 1.33e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 1.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503  55 KEQNFLQGHGNNVSCLAISRSGEYIASGqvtfmGFKVDIILWDYKNRELLARLSLHKGKIEALAFSPNDLYLVSlgGPDD 134
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASG-----SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS--GSDD 351

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19263503 135 GSVVVWSIAkrDAICGSPAAGlNVGNATNVIFSRcRDEMFMTAG-NGTIRVWELD 188
Cdd:COG2319 352 GTVRLWDLA--TGELLRTLTG-HTGAVTSVAFSP-DGRTLASGSaDGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 537-616 2.24e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 2.24e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503 537 IRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKY 616
Cdd:cd00200   2 RRTLKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 450-489 1.26e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.26e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19263503    450 TQKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWD 489
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 100-141 2.72e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.72e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 19263503    100 NRELLARLSLHKGKIEALAFSPNDLYLVSLGgpDDGSVVVWS 141
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
457-489 4.78e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 4.78e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 19263503   457 LKEHKSSVSCIRVKRNNEECVTASTDGTCIIWD 489
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 577-615 6.09e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.09e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19263503    577 GEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWK 615
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 533-573 1.31e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 19263503    533 DGTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWD 573
Cdd:smart00320   1 SGELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 452-537 5.61e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.28  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19263503   452 KLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLR--------------RNQMILANTLFQCVCYHPE---- 513
Cdd:pfam20426 115 RMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRssekrsrntqtefpRKDHVIAETPFHILCGHDDiitc 194

                          90       100
                  ....*....|....*....|....*....
gi 19263503   514 -----EFQIITSGTDrkiaywevfDGTVI 537
Cdd:pfam20426 195 lyvsvELDIVISGSK---------DGTCI 214
WD40 pfam00400
WD domain, G-beta repeat;
577-614 6.90e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 6.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19263503   577 GEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRW 614
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
534-573 7.18e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 7.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 19263503   534 GTVIRELEGSlSGSINGMDITQEGVHFVTGGNDHLVKVWD 573
Cdd:pfam00400   1 GKLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
101-141 9.01e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 9.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 19263503   101 RELLARLSLHKGKIEALAFSPNDLYLVSlGGpDDGSVVVWS 141
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLAS-GS-DDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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