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Conserved domains on  [gi|20380487|gb|AAH28787|]
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Zc3h15 protein [Mus musculus]

Protein Classification

RWD domain-containing protein( domain architecture ID 11243856)

RWD domain-containing protein similar to human RWD domain-containing protein 1 (RWDD1), also called DRG family-regulatory protein 2 (DFRP2), which protects DRG2 from proteolytic degradation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DFRP_C pfam16543
DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation ...
 25-107 7.42e-27

DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation machinery-associated protein 46 proteins that are the binding partner for the highly conserved Developmentally Regulated GTP-binding (DRG) GTPases. Thus this family is referred to as DRG Family Regulatory Proteins (DFRP). Binding of this DFRP modulates the function of the GTPase.


:

Pssm-ID: 465167  Cd Length: 89  Bit Score: 98.43  E-value: 7.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20380487    25 ISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADfkagkalVISGREVFEFRPELVNDDDEEA 104
Cdd:pfam16543   2 ITLEEFIETERHKLDKKLTPVTPETFAKWKKKRIDKKEAEEEAERKKKKAD-------GLSGRELFEFNPDLFEDDDEDE 74


                  ...
gi 20380487   105 DDT 107
Cdd:pfam16543  75 DDD 77
 
Name Accession Description Interval E-value
DFRP_C pfam16543
DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation ...
 25-107 7.42e-27

DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation machinery-associated protein 46 proteins that are the binding partner for the highly conserved Developmentally Regulated GTP-binding (DRG) GTPases. Thus this family is referred to as DRG Family Regulatory Proteins (DFRP). Binding of this DFRP modulates the function of the GTPase.


Pssm-ID: 465167  Cd Length: 89  Bit Score: 98.43  E-value: 7.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20380487    25 ISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADfkagkalVISGREVFEFRPELVNDDDEEA 104
Cdd:pfam16543   2 ITLEEFIETERHKLDKKLTPVTPETFAKWKKKRIDKKEAEEEAERKKKKAD-------GLSGRELFEFNPDLFEDDDEDE 74


                  ...
gi 20380487   105 DDT 107
Cdd:pfam16543  75 DDD 77
COG5252 COG5252
Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function ...
 1-120 1.06e-16

Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227577 [Multi-domain]  Cd Length: 299  Bit Score: 77.05  E-value: 1.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20380487   1 MYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRqekIDKLEQDMERRKADFKAGK 80
Cdd:COG5252 170 SYIHKLPDGYVLSRDKIKDSTQVEISLEEFIELERQSLPEKLTPLTEENFKEWKDGRR---LRILKQKEEKESARKVKGR 246

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 20380487  81 ALVISGREVFEFRPELVNDDDEEADDTRYIQGTGGDEVDD 120
Cdd:COG5252 247 ATGTKGVELFETRRDLFKDDVEAGEEWDYTERCYSESEDE 286
 
Name Accession Description Interval E-value
DFRP_C pfam16543
DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation ...
 25-107 7.42e-27

DRG Family Regulatory Proteins, Tma46; DFRP_C is a family of eukaryotic translation machinery-associated protein 46 proteins that are the binding partner for the highly conserved Developmentally Regulated GTP-binding (DRG) GTPases. Thus this family is referred to as DRG Family Regulatory Proteins (DFRP). Binding of this DFRP modulates the function of the GTPase.


Pssm-ID: 465167  Cd Length: 89  Bit Score: 98.43  E-value: 7.42e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20380487    25 ISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADfkagkalVISGREVFEFRPELVNDDDEEA 104
Cdd:pfam16543   2 ITLEEFIETERHKLDKKLTPVTPETFAKWKKKRIDKKEAEEEAERKKKKAD-------GLSGRELFEFNPDLFEDDDEDE 74


                  ...
gi 20380487   105 DDT 107
Cdd:pfam16543  75 DDD 77
COG5252 COG5252
Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function ...
 1-120 1.06e-16

Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only];


Pssm-ID: 227577 [Multi-domain]  Cd Length: 299  Bit Score: 77.05  E-value: 1.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20380487   1 MYRHALPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRqekIDKLEQDMERRKADFKAGK 80
Cdd:COG5252 170 SYIHKLPDGYVLSRDKIKDSTQVEISLEEFIELERQSLPEKLTPLTEENFKEWKDGRR---LRILKQKEEKESARKVKGR 246

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 20380487  81 ALVISGREVFEFRPELVNDDDEEADDTRYIQGTGGDEVDD 120
Cdd:COG5252 247 ATGTKGVELFETRRDLFKDDVEAGEEWDYTERCYSESEDE 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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