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Conserved domains on  [gi|22028225|gb|AAH34888|]
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Asporin [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12020562)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-317 3.38e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 3.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  82 SDLGLTSVPNNIPFDTRMVDLQNNKIKEIKEND-FKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQLSEIPL 160
Cdd:COG4886  75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 161 NLP--KSLAELRIHDNKVKKIqKDTFKGMNALHVLEMSANplenngiepgafegvtvfhiriaeaKLTSIPKGL--PPTL 236
Cdd:COG4886 154 PLGnlTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-------------------------QITDLPEPLgnLTNL 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 237 LELHLDFNKISTVElEDLKRYRELQRLGLGNNRITDIENgtFANIPRVREIHLEHNKLKKIPSgLQELKYLQIIFLHYNS 316
Cdd:COG4886 208 EELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQ 283


                .
gi 22028225 317 I 317
Cdd:COG4886 284 L 284
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 68-94 1.00e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.54  E-value: 1.00e-06
                          10        20
                  ....*....|....*....|....*..
gi 22028225    68 CPFGCQCYSRVVHCSDLGLTSVPNNIP 94
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-317 3.38e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 3.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  82 SDLGLTSVPNNIPFDTRMVDLQNNKIKEIKEND-FKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQLSEIPL 160
Cdd:COG4886  75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 161 NLP--KSLAELRIHDNKVKKIqKDTFKGMNALHVLEMSANplenngiepgafegvtvfhiriaeaKLTSIPKGL--PPTL 236
Cdd:COG4886 154 PLGnlTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-------------------------QITDLPEPLgnLTNL 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 237 LELHLDFNKISTVElEDLKRYRELQRLGLGNNRITDIENgtFANIPRVREIHLEHNKLKKIPSgLQELKYLQIIFLHYNS 316
Cdd:COG4886 208 EELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQ 283


                .
gi 22028225 317 I 317
Cdd:COG4886 284 L 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-320 9.38e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.75  E-value: 9.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225   84 LGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYAlilNNNKLTKIhPKTFLTT-------------------KK 144
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYA---NSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  145 LRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSanplenngiepgafegvtvfhiriaeak 224
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNS---------------------------- 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  225 LTSIPKGLPPTLLELHLDFNKISTVElEDLKryRELQRLGLGNNRITDIENgTFAniPRVREIHLEHNKLKKIPSGL-QE 303
Cdd:PRK15370 316 LTALPETLPPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLpAA 389

                        250
                 ....*....|....*..
gi 22028225  304 LKYLQIiflHYNSIAKV 320
Cdd:PRK15370 390 LQIMQA---SRNNLVRL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 240-320 1.96e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 1.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 240 HLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENgtFANIPRVREIHLEHNKLKKIPsGLQELKYLQIIFLHYNSIAK 319
Cdd:cd21340   6 HLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISV 82


                .
gi 22028225 320 V 320
Cdd:cd21340  83 V 83
LRR_8 pfam13855
Leucine rich repeat;
98-155 2.96e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 2.96e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 22028225    98 RMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQL 155
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-97 2.57e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.54  E-value: 2.57e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 22028225     68 CPFGCQCYSRVVHCSDLGLTSVPNNIPFDT 97
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 68-94 1.00e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.54  E-value: 1.00e-06
                          10        20
                  ....*....|....*....|....*..
gi 22028225    68 CPFGCQCYSRVVHCSDLGLTSVPNNIP 94
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-317 3.38e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 3.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  82 SDLGLTSVPNNIPFDTRMVDLQNNKIKEIKEND-FKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQLSEIPL 160
Cdd:COG4886  75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 161 NLP--KSLAELRIHDNKVKKIqKDTFKGMNALHVLEMSANplenngiepgafegvtvfhiriaeaKLTSIPKGL--PPTL 236
Cdd:COG4886 154 PLGnlTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-------------------------QITDLPEPLgnLTNL 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 237 LELHLDFNKISTVElEDLKRYRELQRLGLGNNRITDIENgtFANIPRVREIHLEHNKLKKIPSgLQELKYLQIIFLHYNS 316
Cdd:COG4886 208 EELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQ 283


                .
gi 22028225 317 I 317
Cdd:COG4886 284 L 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
84-320 9.38e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.75  E-value: 9.38e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225   84 LGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYAlilNNNKLTKIhPKTFLTT-------------------KK 144
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYA---NSNQLTSI-PATLPDTiqemelsinritelperlpSA 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  145 LRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSanplenngiepgafegvtvfhiriaeak 224
Cdd:PRK15370 264 LQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNS---------------------------- 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  225 LTSIPKGLPPTLLELHLDFNKISTVElEDLKryRELQRLGLGNNRITDIENgTFAniPRVREIHLEHNKLKKIPSGL-QE 303
Cdd:PRK15370 316 LTALPETLPPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVLPE-TLP--PTITTLDVSRNALTNLPENLpAA 389

                        250
                 ....*....|....*..
gi 22028225  304 LKYLQIiflHYNSIAKV 320
Cdd:PRK15370 390 LQIMQA---SRNNLVRL 403
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-317 2.15e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 2.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  77 RVVHCSDLGLTSVPNNIPFDT--RMVDLQNNKIKEIKEnDFKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQ 154
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 155 LSEIPLNL--PKSLAELRIHDNKVKKIqKDTFKGMNALHVLEMSANplenngiepgafegvtvfhiriaeaKLTSIP--K 230
Cdd:COG4886 194 ITDLPEPLgnLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN-------------------------QLTDLPelG 247

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 231 GLPpTLLELHLDFNKISTveLEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLKKIPSGLQELKYLQII 310
Cdd:COG4886 248 NLT-NLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324


                ....*..
gi 22028225 311 FLHYNSI 317
Cdd:COG4886 325 LLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-317 2.00e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 2.00e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  82 SDLGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQlseiPLN 161
Cdd:COG4886  35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----ELS 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 162 LPKSLAELRIHDNKVKKIQKDtFKGMNALHVLEMSANplenngiepgafegvtvfhiriaeaKLTSIPKGLP--PTLLEL 239
Cdd:COG4886 111 NLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNN-------------------------QLTDLPEPLGnlTNLKSL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 240 HLDFNKISTV--ELEDLKRyreLQRLGLGNNRITDIENgTFANIPRVREIHLEHNKLKKIPSGLQELKYLQIIFLHYNSI 317
Cdd:COG4886 165 DLSNNQLTDLpeELGNLTN---LKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-292 4.92e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 4.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  77 RVVHCSDLGLTSVPNNIPFDT--RMVDLQNNKIKEIKEnDFKGLTSLYALILNNNKLTKIhPKTFLTTKKLRRLYLSHNQ 154
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 155 LSEIP--LNLPKsLAELRIHDNKVKKIqkDTFKGMNALHVLEMSANPLENNGIEPGAFEGVTVFHIRIAEAKLTSIPKGL 232
Cdd:COG4886 240 LTDLPelGNLTN-LEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 233 PPTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHN 292
Cdd:COG4886 317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 240-320 1.96e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 1.96e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 240 HLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENgtFANIPRVREIHLEHNKLKKIPsGLQELKYLQIIFLHYNSIAK 319
Cdd:cd21340   6 HLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISV 82


                .
gi 22028225 320 V 320
Cdd:cd21340  83 V 83
LRR_8 pfam13855
Leucine rich repeat;
98-155 2.96e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 2.96e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 22028225    98 RMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQL 155
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-298 1.61e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 1.61e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  79 VHCSDLGLTSVPNNIPF-DTRMVDLQNNKIKEIKENDF-KGLTSLYaliLNNNKLTKIhpkTFLTT-KKLRRLYLSHNQL 155
Cdd:cd21340   7 LYLNDKNITKIDNLSLCkNLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKI---ENLENlVNLKKLYLGGNRI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 156 SEIP-LNLPKSLAELRIhdnkvkkiqkdtfkgmnalhvlemsanplENNGIEPG---AFEGVTVFHIRiaeakltsipkg 231
Cdd:cd21340  81 SVVEgLENLTNLEELHI-----------------------------ENQRLPPGeklTFDPRSLAALS------------ 119

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22028225 232 lpPTLLELHLDFNKISTveLEDLKRYRELQRLGLGNNRITDIEN--GTFANIPRVREIHLEHNKLKKIP 298
Cdd:cd21340 120 --NSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
234-294 8.12e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 8.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22028225   234 PTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKL 294
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
119-200 1.06e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225   119 TSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIPlnlpkslaelrihdnkvkkiqKDTFKGMNALHVLEMSAN 198
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS---------------------PGAFSGLPSLRYLDLSGN 59


                  ..
gi 22028225   199 PL 200
Cdd:pfam13855  60 RL 61
LRR_8 pfam13855
Leucine rich repeat;
258-317 1.12e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.12e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22028225   258 RELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLKKI-PSGLQELKYLQIIFLHYNSI 317
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
68-97 2.57e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 46.54  E-value: 2.57e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 22028225     68 CPFGCQCYSRVVHCSDLGLTSVPNNIPFDT 97
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 121-326 5.48e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 5.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  121 LYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLS-EIPLNLPKS--LAELRIHDNKVKKIQKDTFKGMNALHVLEMSA 197
Cdd:PLN00113 382 LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLplVYFLDISNNNLQGRINSRKWDMPSLQMLSLAR 461

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  198 NPLenNGIEPGAFEGVTVFHIRIAEAKLT-SIPKGLP--PTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIE 274
Cdd:PLN00113 462 NKF--FGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGslSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQI 539

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22028225  275 NGTFANIPRVREIHLEHNKLK-KIPSGLQELKYLQII----------------FLHYNSIAKVGVNDFC 326
Cdd:PLN00113 540 PASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVnishnhlhgslpstgaFLAINASAVAGNIDLC 608
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 98-314 5.93e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 5.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  98 RMVDLQNNKI-----KEIKENdFKGLTSLYALILNNNKLTK---IHPKTFLTT-KKLRRLYLSHNQLSEiplNLPKSLAE 168
Cdd:COG5238 211 TTLWLKRNPIgdegaEILAEA-LKGNKSLTTLDLSNNQIGDegvIALAEALKNnTTVETLYLSGNQIGA---EGAIALAK 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 169 lrihdnkvkkiqkdTFKGMNALHVLEMSANPLenngiepgAFEGVTVFHIRIAEAKltsipkglppTLLELHLDFNKIST 248
Cdd:COG5238 287 --------------ALQGNTTLTSLDLSVNRI--------GDEGAIALAEGLQGNK----------TLHTLNLAYNGIGA 334

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22028225 249 VE----LEDLKRYRELQRLGLGNNRITDIENGTFA----NIPRVREIHLEHNKLKKipSGLQEL-KYLQIIFLHY 314
Cdd:COG5238 335 QGaialAKALQENTTLHSLDLSDNQIGDEGAIALAkyleGNTTLRELNLGKNNIGK--QGAEALiDALQTNRLHT 407
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 68-94 1.00e-06

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 44.54  E-value: 1.00e-06
                          10        20
                  ....*....|....*....|....*..
gi 22028225    68 CPFGCQCYSRVVHCSDLGLTSVPNNIP 94
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 139-333 1.58e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.28  E-value: 1.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 139 FLTTKKLRRLYLSHNQLSE------IPLNLPKSLAELRIHDNKV-----KKIQKDTFKGMNALHVLEMSANPLENNGIEP 207
Cdd:cd00116  77 LTKGCGLQELDLSDNALGPdgcgvlESLLRSSSLQELKLNNNGLgdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEA 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 208 gafegvtvfhirIAEAkLTSIPKglpptLLELHLDFNKIS----TVELEDLKRYRELQRLGLGNNRITDIE----NGTFA 279
Cdd:cd00116 157 ------------LAKA-LRANRD-----LKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTDEGasalAETLA 218

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22028225 280 NIPRVREIHLEHNKL---------KKIPSGLQELKYLQiifLHYNSIAKVGVNDFCPTVPKMK 333
Cdd:cd00116 219 SLKSLEVLNLGDNNLtdagaaalaSALLSPNISLLTLS---LSCNDITDDGAKDLAEVLAEKE 278
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 143-294 5.64e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 5.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 143 KKLRRLYLSHNQLSEIP-LNLPKSLAELRIHDNKVKKIQKdtfkgmnalhvlemsanpLENNgiepgafegvtvfhiria 221
Cdd:cd21340   2 KRITHLYLNDKNITKIDnLSLCKNLKVLYLYDNKITKIEN------------------LEFL------------------ 45

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22028225 222 eakltsipkglpPTLLELHLDFNKIStvELEDLKRYRELQRLGLGNNRITDIENgtFANIPRVREIHLEHNKL 294
Cdd:cd21340  46 ------------TNLTHLYLQNNQIE--KIENLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRL 102
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-282 1.19e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 1.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  77 RVVHCSDLGLTSVPNNIPFDTRM--VDLQNNKIKEIKEndFKGLTSLYALILNNNKLTKIHPKTFLTtkKLRRLYLSHNQ 154
Cdd:COG4886 208 EELDLSGNQLTDLPEPLANLTNLetLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQ 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 155 LSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLENNGIEPGAFEGVTVFHIRIAEAKLTSIPKGLPP 234
Cdd:COG4886 284 LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLL 363

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22028225 235 TLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIP 282
Cdd:COG4886 364 TLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
236-320 1.23e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225 236 LLELHLDFNKistvELEDLKryrELQRLGLGNNRITDIENgTFANIPRVREIHLEHNKLKKIPSGLQELKYLQIIFLHYN 315
Cdd:COG4886  98 LTELDLSGNE----ELSNLT---NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN 169


                ....*
gi 22028225 316 SIAKV 320
Cdd:COG4886 170 QLTDL 174
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
78-309 7.57e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.77  E-value: 7.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225   78 VVHCSDLGLTSVPNNIPFD-TRMVDLQNNkikeikendfkgLTSLYALilnnnkltkihpktfltTKKLRRLYLSHNQLS 156
Cdd:PRK15387 205 VLNVGESGLTTLPDCLPAHiTTLVIPDNN------------LTSLPAL-----------------PPELRTLEVSGNQLT 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  157 EIPLnLPKSLAELRIHDNKVKKIQKDTfkgmNALHVLEMSANPLENNGIEPGAFEGVTVFHIRIAEA------------- 223
Cdd:PRK15387 256 SLPV-LPPGLLELSIFSNPLTHLPALP----SGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLpalpselcklway 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  224 --KLTSIPKgLPPTLLELHLDFNKISTveLEDLKryRELQRLGLGNNRITdiengTFANIPR-VREIHLEHNKLKKIPSG 300
Cdd:PRK15387 331 nnQLTSLPT-LPSGLQELSVSDNQLAS--LPTLP--SELYKLWAYNNRLT-----SLPALPSgLKELIVSGNRLTSLPVL 400


                 ....*....
gi 22028225  301 LQELKYLQI 309
Cdd:PRK15387 401 PSELKELMV 409
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
77-168 3.33e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 42.76  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225   77 RVVHCSDLGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYaliLNNNKLTKIhPKTFltTKKLRRLYLSHNQLS 156
Cdd:PRK15370 328 KTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPPTITTLD---VSRNALTNL-PENL--PAALQIMQASRNNLV 401

                         90
                 ....*....|..
gi 22028225  157 EIPLNLPKSLAE 168
Cdd:PRK15370 402 RLPESLPHFRGE 413
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 100-160 4.17e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 4.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22028225  100 VDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLS-EIPL 160
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIPA 541
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 227-318 6.43e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 6.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  227 SIPKGLPPTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKL-KKIPSGLQELK 305
Cdd:PLN00113 133 SIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMK 212

                         90
                 ....*....|...
gi 22028225  306 YLQIIFLHYNSIA 318
Cdd:PLN00113 213 SLKWIYLGYNNLS 225
PLN03150 PLN03150
hypothetical protein; Provisional
 253-318 1.37e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 1.37e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22028225  253 DLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLK-KIPSGLQELKYLQIIFLHYNSIA 318
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLS 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-317 2.09e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225   61 PFDLFPTCpfgcqcYS-RVVHCSDLGLT-SVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKT 138
Cdd:PLN00113 110 PDDIFTTS------SSlRYLNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNS 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  139 FLTTKKLRRLYLSHNQLS-EIPLNLP--KSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLenNGIEPGAFEGVTV 215
Cdd:PLN00113 184 LTNLTSLEFLTLASNQLVgQIPRELGqmKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL--TGPIPSSLGNLKN 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  216 FH-IRIAEAKLT-SIPKGL--PPTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEH 291
Cdd:PLN00113 262 LQyLFLYQNKLSgPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWS 341

                        250       260
                 ....*....|....*....|....*..
gi 22028225  292 NKLK-KIPSGLQELKYLQIIFLHYNSI 317
Cdd:PLN00113 342 NKFSgEIPKNLGKHNNLTVLDLSTNNL 368
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 104-316 2.79e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  104 NNKIKEIKENdFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLS-EIP--LNLPKSLAELRIHDNKVKKIQ 180
Cdd:PLN00113 246 NNLTGPIPSS-LGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPelVIQLQNLEILHLFSNNFTGKI 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22028225  181 KDTFKGMNALHVLEMSANPLeNNGI--EPGAFEGVTVfhIRIAEAKLTS-IPKGLPPT--LLELHLDFNKISTVELEDLK 255
Cdd:PLN00113 325 PVALTSLPRLQVLQLWSNKF-SGEIpkNLGKHNNLTV--LDLSTNNLTGeIPEGLCSSgnLFKLILFSNSLEGEIPKSLG 401

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22028225  256 RYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLK-KIPSGLQELKYLQIIFLHYNS 316
Cdd:PLN00113 402 ACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNK 463
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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